SIMILAR PATTERNS OF AMINO ACIDS FOR 4M5M_A_DX4A401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a44 PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN

(Bos taurus) 		PF01161
(PBP) 		4 GLY A 146
THR A  68
LEU A  87
PHE A 148
 None
 1.20A 4m5mA-1a44A:
0.2		 4m5mA-1a44A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bih HEMOLIN

(Hyalophora
cecropia) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 THR A  24
LEU A  64
TRP A  50
PHE A  66
 None
 1.16A 4m5mA-1bihA:
undetectable		 4m5mA-1bihA:
17.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cbk PROTEIN
(7,8-DIHYDRO-6-HYDRO
XYMETHYLPTERIN-PYROP
HOSPHOKINASE)

(Haemophilus
influenzae) 		PF01288
(HPPK) 		5 GLY A   9
LEU A  46
TYR A  54
ASN A  56
PHE A 123
 ROI  A 601 ( 3.8A)
ROI  A 601 (-4.2A)
ROI  A 601 (-3.6A)
ROI  A 601 (-3.0A)
ROI  A 601 (-3.4A)
 0.45A 4m5mA-1cbkA:
26.3		 4m5mA-1cbkA:
56.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cbk PROTEIN
(7,8-DIHYDRO-6-HYDRO
XYMETHYLPTERIN-PYROP
HOSPHOKINASE)

(Haemophilus
influenzae) 		PF01288
(HPPK) 		5 GLY A   9
TYR A  54
ASN A  56
ARG A  92
PHE A 123
 ROI  A 601 ( 3.8A)
ROI  A 601 (-3.6A)
ROI  A 601 (-3.0A)
SO4  A 501 ( 2.9A)
ROI  A 601 (-3.4A)
 0.36A 4m5mA-1cbkA:
26.3		 4m5mA-1cbkA:
56.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5j BETA-1,4-XYLANASE

(Dictyoglomus
thermophilum) 		PF00457
(Glyco_hydro_11) 		4 GLY A  49
TYR A  14
TRP A  83
ARG A  47
 None
 1.19A 4m5mA-1f5jA:
undetectable		 4m5mA-1f5jA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		4 GLY A 395
THR A 381
LEU A 418
PHE A 375
 G  B  29 ( 3.2A)
None
None
None
 1.19A 4m5mA-1h3eA:
undetectable		 4m5mA-1h3eA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 GLY A 579
LEU A 573
ASN A 437
PHE A 276
 None
 1.03A 4m5mA-1iv8A:
0.2		 4m5mA-1iv8A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		4 GLY A 371
THR A 513
LEU A 542
ARG A 374
 None
 0.94A 4m5mA-1jy1A:
undetectable		 4m5mA-1jy1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Haemophilus
influenzae) 		PF08282
(Hydrolase_3) 		4 GLY A  96
THR A 102
LEU A  91
PHE A  10
 None
 1.13A 4m5mA-1k1eA:
undetectable		 4m5mA-1k1eA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6y INTEGRASE

(Human
immunodeficiency
virus 1) 		PF00665
(rve)
PF02022
(Integrase_Zn) 		4 GLY A  94
LEU A  63
ASN A 120
PHE A 121
 None
 1.23A 4m5mA-1k6yA:
0.7		 4m5mA-1k6yA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kn3 PHOSPHATIDYLETHANOLA
MINE BINDING
PROTEIN-2

(Mus musculus) 		PF01161
(PBP) 		4 GLY A 147
THR A  69
LEU A  88
PHE A 149
 None
 1.23A 4m5mA-1kn3A:
undetectable		 4m5mA-1kn3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli) 		PF01784
(NIF3) 		4 GLY A 107
THR A 172
LEU A 127
ASN A 108
 None
 1.25A 4m5mA-1nmoA:
undetectable		 4m5mA-1nmoA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnv HYPOTHETICAL PROTEIN
HI1450

(Haemophilus
influenzae) 		PF04269
(DUF440) 		4 GLY A  45
LEU A  36
ARG A  44
PHE A  87
 None
 1.16A 4m5mA-1nnvA:
undetectable		 4m5mA-1nnvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 GLY A 645
THR A 581
LEU A 578
ASN A 644
 None
 0.96A 4m5mA-1obhA:
undetectable		 4m5mA-1obhA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqj FUMARYLACETOACETATE
HYDROLASE

(Mus musculus) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		4 GLY A 343
THR A  66
LEU A 117
ASN A  68
 None
 1.03A 4m5mA-1qqjA:
undetectable		 4m5mA-1qqjA:
16.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ru1 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE

(Escherichia
coli) 		PF01288
(HPPK) 		5 GLY A   8
THR A  42
TYR A  53
ASN A  55
PHE A 123
 PH2  A 181 ( 3.9A)
PH2  A 181 (-3.4A)
PH2  A 181 (-3.6A)
PH2  A 181 (-2.9A)
PH2  A 181 (-3.5A)
 0.43A 4m5mA-1ru1A:
25.5		 4m5mA-1ru1A:
95.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 GLY A 375
THR A 359
TYR A 371
PHE A 357
 None
 1.02A 4m5mA-1ry2A:
undetectable		 4m5mA-1ry2A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s78 PERTUZUMAB FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY D  55
THR D  33
ASN D  52
ARG D  73
 None
 1.24A 4m5mA-1s78D:
undetectable		 4m5mA-1s78D:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)

(Treponema
pallidum) 		PF01297
(ZnuA) 		4 GLY A  90
THR A  39
LEU A  87
TYR A  88
 None
 1.11A 4m5mA-1toaA:
undetectable		 4m5mA-1toaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		no annotation 4 GLY B 801
THR B 825
LEU B 821
ARG B 805
 None
 0.93A 4m5mA-1us8B:
undetectable		 4m5mA-1us8B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 GLY A 174
LEU A 167
ASN A 201
PHE A 191
 None
 0.99A 4m5mA-1vclA:
undetectable		 4m5mA-1vclA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 GLY A 262
LEU A 255
ASN A 160
PHE A 279
 None
 0.90A 4m5mA-1vclA:
undetectable		 4m5mA-1vclA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLY A 399
THR A 420
TYR A 398
ASN A 418
 None
 1.23A 4m5mA-1w9xA:
undetectable		 4m5mA-1w9xA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5y MYOSIN BINDING
PROTEIN C, FAST-TYPE

(Mus musculus) 		PF00041
(fn3) 		4 GLY A  90
THR A   9
ASN A  87
ARG A  91
 None
 1.22A 4m5mA-1x5yA:
undetectable		 4m5mA-1x5yA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfg GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Escherichia
coli) 		PF13522
(GATase_6) 		4 GLY A  19
THR A  72
LEU A  54
ARG A  21
 None
 1.22A 4m5mA-1xfgA:
undetectable		 4m5mA-1xfgA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmx HYPOTHETICAL PROTEIN
VC1899

(Vibrio cholerae) 		PF09002
(DUF1887) 		4 GLY A 249
THR A 254
LEU A 171
PHE A 246
 None
FMT  A 406 (-4.3A)
None
None
 1.19A 4m5mA-1xmxA:
undetectable		 4m5mA-1xmxA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE

(Methanosarcina
barkeri) 		PF00296
(Bac_luciferase) 		4 GLY A  95
THR A  67
TYR A  66
ASN A  64
 F42  A 328 (-3.0A)
None
None
None
 1.26A 4m5mA-1z69A:
undetectable		 4m5mA-1z69A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		4 GLY A 136
LEU A 109
ARG A 135
PHE A 155
 None
 1.18A 4m5mA-2d3iA:
undetectable		 4m5mA-2d3iA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsq ATU0111 PROTEIN

(Agrobacterium
fabrum) 		PF08975
(2H-phosphodiest) 		4 GLY A  88
THR A 113
TYR A 116
ASN A  41
 None
 1.01A 4m5mA-2fsqA:
1.1		 4m5mA-2fsqA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2him L-ASPARAGINASE 1

(Escherichia
coli) 		PF00710
(Asparaginase) 		4 GLY A 128
THR A 115
ASN A 131
PHE A 151
 None
 1.06A 4m5mA-2himA:
undetectable		 4m5mA-2himA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1

(Rattus
norvegicus) 		PF01161
(PBP) 		4 GLY A 147
THR A  69
LEU A  88
PHE A 149
 None
 1.24A 4m5mA-2iqxA:
undetectable		 4m5mA-2iqxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrk HYPOTHETICAL PROTEIN
GRPB

(Enterococcus
faecalis) 		PF04229
(GrpB) 		4 GLY A  85
TYR A 103
ASN A 107
ARG A  86
 None
 1.13A 4m5mA-2nrkA:
undetectable		 4m5mA-2nrkA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9r BETA-GLUCOSIDASE B

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		4 GLY A 419
THR A  16
LEU A  73
PHE A 404
 None
 0.96A 4m5mA-2o9rA:
undetectable		 4m5mA-2o9rA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF01728
(FtsJ) 		4 GLY A 198
LEU A 167
ARG A 199
PHE A 171
 None
 1.08A 4m5mA-2plwA:
undetectable		 4m5mA-2plwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 4 LEU A  36
TYR A 230
ASN A 136
ARG A 128
 None
 0.99A 4m5mA-2po4A:
undetectable		 4m5mA-2po4A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm3 PREDICTED
METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01861
(DUF43) 		4 THR A 133
LEU A 140
ASN A 287
PHE A 286
 None
 1.12A 4m5mA-2qm3A:
undetectable		 4m5mA-2qm3A:
18.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qx0 7,8-DIHYDRO-6-HYDROX
YMETHYLPTERIN-PYROPH
OSPHOKINASE

(Yersinia pestis) 		PF01288
(HPPK) 		4 GLY A   9
THR A  43
ASN A  56
PHE A 124
 PH2  A 181 ( 4.3A)
PH2  A 181 (-3.8A)
PH2  A 181 (-2.9A)
PH2  A 181 (-3.4A)
 0.28A 4m5mA-2qx0A:
26.3		 4m5mA-2qx0A:
62.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qx0 7,8-DIHYDRO-6-HYDROX
YMETHYLPTERIN-PYROPH
OSPHOKINASE

(Yersinia pestis) 		PF01288
(HPPK) 		4 GLY A   9
THR A  43
LEU A  46
PHE A 124
 PH2  A 181 ( 4.3A)
PH2  A 181 (-3.8A)
PH2  A 181 (-3.7A)
PH2  A 181 (-3.4A)
 0.74A 4m5mA-2qx0A:
26.3		 4m5mA-2qx0A:
62.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 420
LEU A 449
TYR A  56
ASN A  53
 None
 1.26A 4m5mA-2vk4A:
undetectable		 4m5mA-2vk4A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9p PIMD PROTEIN

(Streptomyces
natalensis) 		PF00067
(p450) 		4 GLY A 312
LEU A 275
ASN A 315
ARG A 279
 None
 0.96A 4m5mA-2x9pA:
undetectable		 4m5mA-2x9pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 GLY A 470
THR A 632
TYR A 522
ASN A 519
 None
 1.20A 4m5mA-2xaxA:
undetectable		 4m5mA-2xaxA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		4 GLY A 246
THR A  37
LEU A  34
PHE A   8
 None
 1.10A 4m5mA-2yb4A:
undetectable		 4m5mA-2yb4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yx8 RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1

(Homo sapiens) 		PF04901
(RAMP) 		4 GLY A  33
THR A  73
LEU A  41
PHE A  92
 None
 1.17A 4m5mA-2yx8A:
undetectable		 4m5mA-2yx8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bac DNA LIGASE

(Haemophilus
influenzae) 		PF01653
(DNA_ligase_aden) 		4 THR A 216
LEU A 211
ASN A 149
ARG A 209
 None
 1.19A 4m5mA-3bacA:
undetectable		 4m5mA-3bacA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhg ADENYLOSUCCINATE
LYASE

(Legionella
pneumophila) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 GLY A  14
THR A  20
TYR A  16
ARG A  15
 None
 1.19A 4m5mA-3bhgA:
undetectable		 4m5mA-3bhgA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdk SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
B

(Bacillus
subtilis) 		PF01144
(CoA_trans) 		4 GLY B 103
THR B 163
LEU B 132
ASN B 115
 None
 1.00A 4m5mA-3cdkB:
undetectable		 4m5mA-3cdkB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dul O-METHYLTRANSFERASE,
PUTATIVE

(Bacillus cereus) 		PF01596
(Methyltransf_3) 		4 GLY A  69
LEU A  25
ASN A  32
TRP A  75
 None
 1.10A 4m5mA-3dulA:
1.6		 4m5mA-3dulA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec2 DNA REPLICATION
PROTEIN DNAC

(Aquifex
aeolicus) 		PF01695
(IstB_IS21) 		4 GLY A  91
THR A 180
LEU A 218
PHE A  84
 ADP  A 222 (-3.2A)
None
None
None
 1.18A 4m5mA-3ec2A:
undetectable		 4m5mA-3ec2A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 GLY A 237
LEU A 152
TYR A 232
TRP A 438
 None
 0.86A 4m5mA-3h7lA:
undetectable		 4m5mA-3h7lA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A  50
THR A 110
LEU A 306
ARG A 118
 None
 1.03A 4m5mA-3i6tA:
undetectable		 4m5mA-3i6tA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7j BETA-LACTAMASE
MB2281C

(Mycobacterium
bovis) 		PF00144
(Beta-lactamase) 		4 GLY A 216
THR A 223
LEU A 242
ASN A 219
 None
 1.02A 4m5mA-3i7jA:
undetectable		 4m5mA-3i7jA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k50 PUTATIVE S41
PROTEASE

(Bacteroides
fragilis) 		PF03572
(Peptidase_S41) 		4 LEU A 152
TYR A  96
ARG A 158
PHE A  98
 None
 0.91A 4m5mA-3k50A:
undetectable		 4m5mA-3k50A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kc2 UNCHARACTERIZED
PROTEIN YKR070W

(Saccharomyces
cerevisiae) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 GLY A  55
THR A 101
ASN A 162
ARG A  62
 None
 1.23A 4m5mA-3kc2A:
undetectable		 4m5mA-3kc2A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n1g BROTHER OF CDO

(Homo sapiens) 		PF00041
(fn3) 		4 GLY C 796
THR C 743
ASN C 794
ARG C 711
 None
 1.07A 4m5mA-3n1gC:
undetectable		 4m5mA-3n1gC:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7p RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1

(Homo sapiens) 		PF04901
(RAMP) 		4 GLY D  33
THR D  73
LEU D  41
PHE D  92
 None
 1.12A 4m5mA-3n7pD:
undetectable		 4m5mA-3n7pD:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n90 THYLAKOID LUMENAL 15
KDA PROTEIN 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00805
(Pentapeptide) 		4 GLY A 186
THR A 220
LEU A 202
PHE A 189
 None
 0.79A 4m5mA-3n90A:
undetectable		 4m5mA-3n90A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvq SEMAPHORIN-7A

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF13895
(Ig_2) 		4 GLY A  93
THR A 110
ASN A 112
ARG A  92
 None
 1.24A 4m5mA-3nvqA:
undetectable		 4m5mA-3nvqA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 GLY A 230
THR A  90
LEU A 146
ASN A  54
 None
 0.85A 4m5mA-3qfkA:
undetectable		 4m5mA-3qfkA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwu DNA LIGASE

(Aquifex
aeolicus) 		PF09414
(RNA_ligase) 		4 THR A 229
LEU A 234
TYR A 231
ASN A 206
 None
 1.07A 4m5mA-3qwuA:
undetectable		 4m5mA-3qwuA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica) 		PF00291
(PALP) 		4 GLY A 277
LEU A 274
TRP A 420
PHE A 301
 SO4  A 449 (-3.4A)
None
None
None
 1.21A 4m5mA-3r0zA:
undetectable		 4m5mA-3r0zA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r24 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		4 GLY A 278
LEU A  57
ASN A 210
ARG A 255
 None
 1.15A 4m5mA-3r24A:
undetectable		 4m5mA-3r24A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3raz THIOREDOXIN-RELATED
PROTEIN

(Neisseria
meningitidis) 		PF08534
(Redoxin) 		4 GLY A  79
THR A 126
LEU A 123
ASN A  47
 None
 1.19A 4m5mA-3razA:
undetectable		 4m5mA-3razA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re2 PREDICTED PROTEIN

(Nematostella
vectensis) 		PF05053
(Menin) 		4 GLY A  39
LEU A 121
TYR A 118
ASN A 116
 None
 1.22A 4m5mA-3re2A:
undetectable		 4m5mA-3re2A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tg9 PENICILLIN-BINDING
PROTEIN

(Bacillus
halodurans) 		PF00144
(Beta-lactamase) 		4 GLY A 226
THR A  59
TRP A 274
PHE A 155
 None
 1.25A 4m5mA-3tg9A:
undetectable		 4m5mA-3tg9A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v42 FOLLICULIN

(Homo sapiens) 		PF16692
(Folliculin_C) 		4 GLY A 371
LEU A 391
ASN A 416
PHE A 417
 None
 1.23A 4m5mA-3v42A:
undetectable		 4m5mA-3v42A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 GLY A  30
LEU A 248
TYR A  31
ASN A  29
 None
 0.97A 4m5mA-3wiqA:
undetectable		 4m5mA-3wiqA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 GLY A 615
THR A 657
LEU A 663
ARG A 618
 None
 1.25A 4m5mA-3zhrA:
undetectable		 4m5mA-3zhrA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0n POLYKETIDE SYNTHASE
III

(Ectocarpus
siliculosus) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 GLY A 333
LEU A 239
ASN A 364
PHE A 243
 None
None
None
ACD  A1416 (-4.9A)
 1.06A 4m5mA-4b0nA:
undetectable		 4m5mA-4b0nA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 GLY A  28
THR A  34
TYR A  30
ARG A  29
 None
 1.13A 4m5mA-4efcA:
undetectable		 4m5mA-4efcA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzh HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 GLY A 402
THR A 528
TRP A 615
ARG A 416
 None
 1.16A 4m5mA-4fzhA:
undetectable		 4m5mA-4fzhA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

([Haemophilus]
ducreyi) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		4 GLY A 448
THR A 420
ASN A 445
PHE A 391
 None
 1.22A 4m5mA-4k3cA:
undetectable		 4m5mA-4k3cA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lub PUTATIVE PREPHENATE
DEHYDRATASE

(Streptococcus
mutans) 		PF00800
(PDT) 		4 GLY A  12
LEU A  32
TYR A  10
PHE A  34
 None
 1.19A 4m5mA-4lubA:
4.2		 4m5mA-4lubA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 GLY A 105
THR A 148
LEU A 101
ASN A 126
 None
 1.14A 4m5mA-4p22A:
undetectable		 4m5mA-4p22A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 GLY A   8
ASN A  60
ARG A  97
PHE A 128
 J1D  A 501 ( 4.3A)
J1D  A 501 (-3.1A)
J1D  A 501 (-2.8A)
J1D  A 501 (-3.1A)
 0.47A 4m5mA-4pzvA:
23.9		 4m5mA-4pzvA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qku HYDROLASE

(Burkholderia
cenocepacia) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		4 GLY A 358
THR A  81
LEU A 132
ASN A  83
 None
 1.17A 4m5mA-4qkuA:
undetectable		 4m5mA-4qkuA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		4 GLY C 518
THR C 556
ARG C 197
PHE C 555
 None
 1.21A 4m5mA-4yfaC:
undetectable		 4m5mA-4yfaC:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avp L-RIBOSE ISOMERASE

(Geodermatophilus
obscurus) 		no annotation 4 GLY A  26
LEU A  19
TRP A  18
PHE A  70
 None
 1.21A 4m5mA-5avpA:
undetectable		 4m5mA-5avpA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis) 		no annotation 4 GLY A 303
LEU A 368
ASN A 302
ARG A 304
 None
 1.17A 4m5mA-5awpA:
undetectable		 4m5mA-5awpA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza C
virus;
Influenza C
virus) 		PF00602
(Flu_PB1)
PF00604
(Flu_PB2) 		4 GLY B 128
THR B 131
LEU B 146
TRP C  38
 None
 1.09A 4m5mA-5d9aB:
undetectable		 4m5mA-5d9aB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl6 PUTATIVE PORIN FOR
VANILLATE
TRAFFICKING (VANP)

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 GLY A  75
THR A  35
ASN A  76
PHE A  16
 None
 1.10A 4m5mA-5dl6A:
undetectable		 4m5mA-5dl6A:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ets 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE

(Staphylococcus
aureus) 		no annotation 5 GLY B   9
THR B  43
ASN B  56
ARG B  92
PHE B 123
 5RX  B 202 ( 4.4A)
5RX  B 202 (-3.8A)
5RX  B 202 (-3.2A)
APC  B 201 ( 3.1A)
5RX  B 202 (-3.3A)
 0.45A 4m5mA-5etsB:
26.4		 4m5mA-5etsB:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezd KUNITZ-TYPE PROTEASE
INHIBITOR 1

(Homo sapiens) 		PF00014
(Kunitz_BPTI) 		4 GLY A 194
LEU A 210
TYR A 218
PHE A 220
 None
 1.23A 4m5mA-5ezdA:
undetectable		 4m5mA-5ezdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guj DNA PRIMASE

(Bacillus
subtilis) 		PF08275
(Toprim_N)
PF10410
(DnaB_bind)
PF13155
(Toprim_2) 		4 GLY A 198
THR A 171
TYR A 199
ARG A 192
 None
 1.02A 4m5mA-5gujA:
undetectable		 4m5mA-5gujA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 THR A 237
LEU A 150
ASN A 235
ARG A 489
 None
 1.10A 4m5mA-5ikpA:
undetectable		 4m5mA-5ikpA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvf SITE-DETERMINING
PROTEIN

(Pseudomonas
aeruginosa) 		PF10609
(ParA) 		4 LEU A 263
ASN A 258
ARG A 260
PHE A 265
 IOD  A 302 (-4.9A)
IOD  A 302 ( 4.9A)
None
None
 0.79A 4m5mA-5jvfA:
undetectable		 4m5mA-5jvfA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k79 CYANOVIRIN-N DOMAIN
PROTEIN

(Cyanothece sp.
PCC 7424) 		PF08881
(CVNH) 		4 GLY A  46
THR A  58
ASN A  43
ARG A  81
 None
 1.19A 4m5mA-5k79A:
undetectable		 4m5mA-5k79A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 4 GLY B 399
THR B 395
TYR B 397
PHE B 392
 None
 1.07A 4m5mA-5khnB:
5.3		 4m5mA-5khnB:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 GLY A 713
LEU A 706
TRP A 704
PHE A 710
 None
 1.25A 4m5mA-5ksdA:
undetectable		 4m5mA-5ksdA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myu TYPE VI SECRETION
SYSTEM PROTEIN IMPC

(Vibrio cholerae) 		PF05943
(VipB) 		4 GLY A 275
LEU A  99
TRP A  96
PHE A 279
 None
 1.11A 4m5mA-5myuA:
undetectable		 4m5mA-5myuA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR

(Homo sapiens) 		PF00002
(7tm_2)
PF02793
(HRM) 		4 THR A 149
LEU A 388
TYR A 152
ARG A 190
 None
 1.01A 4m5mA-5nx2A:
undetectable		 4m5mA-5nx2A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvd TM16

(Trichuris muris) 		PF01161
(PBP) 		4 GLY A 150
THR A  71
LEU A  90
PHE A 152
 None
 1.21A 4m5mA-5tvdA:
undetectable		 4m5mA-5tvdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR

(Escherichia
coli;
Homo sapiens) 		no annotation 4 GLY A1033
THR A1073
LEU A1041
PHE A1092
 None
 1.21A 4m5mA-5v6yA:
undetectable		 4m5mA-5v6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1

(Homo sapiens) 		PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3) 		4 THR A 566
LEU A1377
ASN A1633
ARG A 557
 None
 1.18A 4m5mA-5xjyA:
undetectable		 4m5mA-5xjyA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnc -

(-) 		no annotation 4 THR A 134
LEU A 141
ASN A 288
PHE A 287
 None
 1.07A 4m5mA-5xncA:
undetectable		 4m5mA-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 4 GLY C 692
LEU C 710
TYR C 709
ASN C 703
 None
 1.01A 4m5mA-5y6qC:
undetectable		 4m5mA-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjh PERIOSTIN

(Homo sapiens) 		no annotation 4 GLY A 264
THR A 353
LEU A 271
ASN A 355
 None
 1.13A 4m5mA-5yjhA:
undetectable		 4m5mA-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 4 GLY A 198
THR A 190
ASN A 199
PHE A 227
 None
 1.25A 4m5mA-5yp3A:
undetectable		 4m5mA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Oryctolagus
cuniculus) 		no annotation 4 GLY A 506
THR A 406
LEU A 499
PHE A 405
 None
 1.23A 4m5mA-6bwmA:
undetectable		 4m5mA-6bwmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f79 -

(-) 		no annotation 4 GLY A 170
THR A 179
ASN A 148
ARG A 171
 None
 0.95A 4m5mA-6f79A:
undetectable		 4m5mA-6f79A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdt -

(-) 		no annotation 4 GLY A 237
LEU A 152
TYR A 232
TRP A 438
 None
 0.90A 4m5mA-6gdtA:
undetectable		 4m5mA-6gdtA:
undetectable