SIMILAR PATTERNS OF AMINO ACIDS FOR 4M48_A_21BA704_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4e CATALASE A

(Saccharomyces
cerevisiae)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 VAL A 121
ASP A 123
GLY A 113
ALA A 251
None
0.88A 4m48A-1a4eA:
0.0
4m48A-1a4eA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE


(Human
alphaherpesvirus
2)
PF00716
(Peptidase_S21)
4 ASP A 169
VAL A  83
SER A 167
ALA A  72
None
0.86A 4m48A-1at3A:
0.0
4m48A-1at3A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8x PROTEIN (AML-1B)

(Escherichia
coli)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 ASP A 100
TYR A 103
GLY A  96
ALA A 157
None
0.80A 4m48A-1b8xA:
0.0
4m48A-1b8xA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis)
PF00405
(Transferrin)
4 PHE A 152
VAL A 206
ASP A 205
ALA A  96
None
0.92A 4m48A-1biyA:
0.0
4m48A-1biyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs9 ACETYL XYLAN
ESTERASE


(Talaromyces
purpureogenus)
PF01083
(Cutinase)
4 VAL A  68
TYR A  43
GLY A   9
ALA A  99
None
0.88A 4m48A-1bs9A:
0.0
4m48A-1bs9A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl3 PROTEIN
(PHOSPHORIBOSYLANTRA
NILATE ISOMERASE)


(Thermotoga
maritima)
PF00697
(PRAI)
5 VAL A   4
ASP A  24
SER A  18
GLY A  22
ALA A 202
None
1.17A 4m48A-1dl3A:
0.0
4m48A-1dl3A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE


(Paracoccus
pantotrophus)
PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3)
4 ASP A 536
TYR A 455
GLY A 508
ALA A 393
None
0.90A 4m48A-1gq1A:
0.0
4m48A-1gq1A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvc OVOTRANSFERRIN

(Anas
platyrhynchos)
PF00405
(Transferrin)
4 PHE A 158
VAL A 208
ASP A 207
ALA A  99
None
0.89A 4m48A-1gvcA:
undetectable
4m48A-1gvcA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h76 SEROTRANSFERRIN

(Sus scrofa)
PF00405
(Transferrin)
4 PHE A 152
VAL A 206
ASP A 205
ALA A  98
None
0.90A 4m48A-1h76A:
0.0
4m48A-1h76A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h76 SEROTRANSFERRIN

(Sus scrofa)
PF00405
(Transferrin)
4 PHE A 485
VAL A 539
ASP A 538
ALA A 435
None
0.89A 4m48A-1h76A:
0.0
4m48A-1h76A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus)
PF00405
(Transferrin)
4 PHE A 153
VAL A 202
ASP A 201
ALA A  99
None
0.85A 4m48A-1jnfA:
0.0
4m48A-1jnfA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus)
PF00405
(Transferrin)
4 PHE A 478
VAL A 527
ASP A 526
ALA A 429
None
0.89A 4m48A-1jnfA:
0.0
4m48A-1jnfA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE


(Rhodospirillum
rubrum)
PF03063
(Prismane)
4 ASP A 282
VAL A 258
GLY A 288
ALA A 387
None
0.88A 4m48A-1jqkA:
2.1
4m48A-1jqkA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
4 PHE A2615
VAL A2527
TYR A2536
ALA A2581
None
0.90A 4m48A-1js8A:
undetectable
4m48A-1js8A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6j MATRIX
METALLOPROTEINASE-9


(Homo sapiens)
PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1)
4 PHE A 425
VAL A 217
SER A 394
ALA A 229
None
0.91A 4m48A-1l6jA:
undetectable
4m48A-1l6jA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lln ANTIVIRAL PROTEIN 3

(Phytolacca
americana)
PF00161
(RIP)
5 ASP A 196
VAL A 183
TYR A 193
GLY A 131
ALA A 173
MLY  A 198 ( 3.8A)
MLY  A 184 ( 3.1A)
MLY  A 182 ( 3.3A)
None
None
1.45A 4m48A-1llnA:
undetectable
4m48A-1llnA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Tritrichomonas
suis)
PF00478
(IMPDH)
4 ASP A 264
ASP A 358
SER A 263
ALA A 334
TRS  A 600 ( 3.1A)
IMP  A 801 (-2.5A)
TAD  A 901 (-2.7A)
None
0.88A 4m48A-1lrtA:
undetectable
4m48A-1lrtA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Tritrichomonas
suis)
PF00478
(IMPDH)
PF00571
(CBS)
4 ASP A 264
ASP A 358
SER A 263
ALA A 334
K  A 900 (-2.4A)
XMP  A 602 (-2.7A)
NAD  A 987 (-3.1A)
None
0.91A 4m48A-1mewA:
undetectable
4m48A-1mewA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nff PUTATIVE
OXIDOREDUCTASE
RV2002


(Mycobacterium
tuberculosis)
PF13561
(adh_short_C2)
4 ASP A  41
TYR A  57
GLY A  14
ALA A  71
None
None
NAD  A1300 (-3.5A)
None
0.85A 4m48A-1nffA:
undetectable
4m48A-1nffA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2


(Synechocystis
sp. PCC 6803)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
4 VAL A  46
TYR A 175
GLY A 185
ALA A 201
None
0.87A 4m48A-1ofeA:
undetectable
4m48A-1ofeA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT


(Paracoccus
denitrificans)
no annotation 4 PHE B 265
VAL B 261
SER B 264
GLY B 257
None
0.77A 4m48A-1pbyB:
undetectable
4m48A-1pbyB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgu PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)


(Klebsiella
pneumoniae)
PF00148
(Oxidored_nitro)
5 ASP A 460
ASP A 232
TYR A 448
SER A 445
GLY A 230
None
1.38A 4m48A-1qguA:
undetectable
4m48A-1qguA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT


(Escherichia
coli)
PF00161
(RIP)
4 PHE A  95
ASP A 111
VAL A 158
GLY A  80
None
0.93A 4m48A-1r4pA:
undetectable
4m48A-1r4pA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE


(Staphylococcus
aureus)
PF00348
(polyprenyl_synt)
4 PHE A 288
TYR A 206
GLY A 211
ALA A 185
None
0.92A 4m48A-1rtrA:
1.9
4m48A-1rtrA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryo SEROTRANSFERRIN

(Homo sapiens)
PF00405
(Transferrin)
4 PHE A 153
VAL A 202
ASP A 201
ALA A  99
None
0.88A 4m48A-1ryoA:
undetectable
4m48A-1ryoA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg)
4 ASP A 151
SER A 105
GLY A 101
ALA A 196
GLA  A 500 (-3.0A)
MG  A 600 (-4.0A)
ADP  A 400 (-3.2A)
None
0.84A 4m48A-1s4eA:
undetectable
4m48A-1s4eA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb7 TRNA PSEUDOURIDINE
SYNTHASE D


(Escherichia
coli)
PF01142
(TruD)
4 VAL A  46
TYR A 114
SER A 102
ALA A  91
None
0.93A 4m48A-1sb7A:
undetectable
4m48A-1sb7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sef CONSERVED
HYPOTHETICAL PROTEIN


(Enterococcus
faecalis)
PF05899
(Cupin_3)
PF07883
(Cupin_2)
4 VAL A 168
TYR A 162
GLY A 164
ALA A 193
None
0.85A 4m48A-1sefA:
undetectable
4m48A-1sefA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv SEROTRANSFERRIN,
C-LOBE


(Homo sapiens)
PF00405
(Transferrin)
4 PHE E 478
VAL E 527
ASP E 526
ALA E 429
None
0.89A 4m48A-1suvE:
undetectable
4m48A-1suvE:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE


(Synechococcus
elongatus)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
4 ASP A 362
ASP A 335
GLY A 330
ALA A 412
None
0.89A 4m48A-1tezA:
undetectable
4m48A-1tezA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE


(Shewanella
massilia)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
4 PHE A  19
ASP A  37
TYR A 496
GLY A  13
None
0.88A 4m48A-1tmoA:
undetectable
4m48A-1tmoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp8 AGGLUTININ ALPHA
CHAIN


(Artocarpus
hirsutus)
PF01419
(Jacalin)
5 VAL A  80
ASP A 125
TYR A  78
GLY A 121
ALA A  24
None
AMG  A 500 (-2.9A)
AMG  A 500 (-3.7A)
AMG  A 500 ( 3.7A)
None
1.12A 4m48A-1tp8A:
undetectable
4m48A-1tp8A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz6 PUTATIVE SUGAR
KINASE


(Salmonella
enterica)
PF00294
(PfkB)
5 ASP A 158
VAL A   9
TYR A 126
SER A 128
GLY A  11
ACP  A 401 (-3.4A)
None
None
None
None
1.47A 4m48A-1tz6A:
undetectable
4m48A-1tz6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus)
PF00378
(ECH_1)
4 PHE A  56
VAL A   2
SER A  57
GLY A  51
None
0.90A 4m48A-1uiyA:
undetectable
4m48A-1uiyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v15 COLICIN E9

(Escherichia
coli)
no annotation 4 ASP A  51
VAL A 113
SER A  49
GLY A   9
None
0.92A 4m48A-1v15A:
undetectable
4m48A-1v15A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME


(Campylobacter
jejuni)
PF01128
(IspD)
PF02542
(YgbB)
4 PHE A  69
VAL A  97
SER A  54
ALA A  37
None
C  A1373 (-4.4A)
None
None
0.89A 4m48A-1w55A:
undetectable
4m48A-1w55A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI


(Escherichia
coli)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
4 VAL A 547
SER A 288
GLY A 292
ALA A 550
None
0.86A 4m48A-1we5A:
undetectable
4m48A-1we5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xbz 3-KETO-L-GULONATE
6-PHOSPHATE
DECARBOXYLASE


(Escherichia
coli)
PF00215
(OMPdecase)
5 PHE A 164
VAL A 109
ASP A 108
GLY A 131
ALA A  95
None
1.21A 4m48A-1xbzA:
undetectable
4m48A-1xbzA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwm PHOSPHATE UPTAKE
REGULATOR


(Geobacillus
stearothermophilus)
PF01895
(PhoU)
4 VAL A 155
ASP A 156
TYR A 159
ALA A 126
None
0.84A 4m48A-1xwmA:
3.1
4m48A-1xwmA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14


(Homo sapiens)
PF00443
(UCH)
5 ASP A 198
TYR A 435
SER A 430
GLY A 427
ALA A 474
None
1.18A 4m48A-2aynA:
undetectable
4m48A-2aynA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2blb DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Plasmodium
vivax)
PF00186
(DHFR_1)
4 VAL A 204
ASP A 203
GLY A  43
ALA A 176
None
None
NDP  A1239 (-3.3A)
NDP  A1239 (-3.3A)
0.92A 4m48A-2blbA:
undetectable
4m48A-2blbA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzu FIBER PROTEIN 2

(Human
mastadenovirus
F)
PF00541
(Adeno_knob)
4 PHE A 374
TYR A 245
GLY A 271
ALA A 300
None
0.91A 4m48A-2bzuA:
undetectable
4m48A-2bzuA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE


(Mytilus edulis)
PF00150
(Cellulase)
5 ASP A 245
VAL A 219
TYR A 255
SER A 239
ALA A 223
None
1.38A 4m48A-2c0hA:
undetectable
4m48A-2c0hA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus)
PF00405
(Transferrin)
4 PHE A 155
VAL A 205
ASP A 204
ALA A  96
None
0.91A 4m48A-2d3iA:
undetectable
4m48A-2d3iA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d88 PROTEIN MICAL-3

(Homo sapiens)
PF00307
(CH)
4 VAL A  30
SER A  12
GLY A  16
ALA A  42
None
0.89A 4m48A-2d88A:
undetectable
4m48A-2d88A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4p BIPHENYL DIOXYGENASE
FERREDOXIN SUBUNIT


(Pseudomonas sp.)
PF00355
(Rieske)
4 VAL A 100
ASP A 101
TYR A  89
ALA A   6
None
0.78A 4m48A-2e4pA:
undetectable
4m48A-2e4pA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri)
PF01979
(Amidohydro_1)
4 ASP A 129
TYR A 130
GLY A 515
ALA A  86
None
0.92A 4m48A-2fvmA:
undetectable
4m48A-2fvmA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h12 CITRATE SYNTHASE

(Acetobacter
aceti)
PF00285
(Citrate_synt)
4 VAL A  35
ASP A  34
GLY A  29
ALA A  58
None
0.75A 4m48A-2h12A:
undetectable
4m48A-2h12A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hau SEROTRANSFERRIN

(Homo sapiens)
PF00405
(Transferrin)
4 PHE A 153
VAL A 202
ASP A 201
ALA A  99
None
0.83A 4m48A-2hauA:
undetectable
4m48A-2hauA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE


(Archaeoglobus
fulgidus)
PF00122
(E1-E2_ATPase)
4 ASP A 260
VAL A 249
GLY A 246
ALA A 227
None
0.89A 4m48A-2hc8A:
undetectable
4m48A-2hc8A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT


(Pseudomonas
stutzeri)
PF02332
(Phenol_Hydrox)
4 VAL B 183
ASP B 182
TYR B 180
ALA B 122
None
0.85A 4m48A-2incB:
1.2
4m48A-2incB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes)
PF00534
(Glycos_transf_1)
4 VAL A 245
SER A 249
GLY A 280
ALA A 271
None
0.82A 4m48A-2iuyA:
undetectable
4m48A-2iuyA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4g HYALURONOGLUCOSAMINI
DASE


(Bacteroides
thetaiotaomicron)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase)
4 ASP A 168
TYR A 163
GLY A 135
ALA A 238
None
None
NB1  A1590 (-4.8A)
None
0.83A 4m48A-2j4gA:
2.2
4m48A-2j4gA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2llf VILLIN-1

(Gallus gallus)
PF00626
(Gelsolin)
4 ASP A  27
TYR A  32
GLY A  45
ALA A  56
None
0.90A 4m48A-2llfA:
undetectable
4m48A-2llfA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lwf MONOTHIOL
GLUTAREDOXIN-S16,
CHLOROPLASTIC


(Arabidopsis
thaliana)
no annotation 4 VAL A 128
TYR A  90
SER A 105
GLY A  88
None
0.91A 4m48A-2lwfA:
undetectable
4m48A-2lwfA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli)
PF00006
(ATP-synt_ab)
4 ASP A 286
VAL A 295
GLY A 279
ALA A 272
None
0.90A 4m48A-2obmA:
undetectable
4m48A-2obmA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcr INOSITOL-1-MONOPHOSP
HATASE


(Aquifex
aeolicus)
PF00459
(Inositol_P)
4 VAL A 192
ASP A 193
GLY A 188
ALA A 102
None
0.91A 4m48A-2pcrA:
undetectable
4m48A-2pcrA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis)
PF00378
(ECH_1)
5 PHE A 231
VAL A 167
SER A 232
GLY A 217
ALA A 200
None
0.91A 4m48A-2pg8A:
undetectable
4m48A-2pg8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE


(Homo sapiens)
no annotation 4 PHE B 196
VAL B 241
GLY B 243
ALA B 270
None
0.91A 4m48A-2pvcB:
undetectable
4m48A-2pvcB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q34 CURF

(Moorea
producens)
PF00378
(ECH_1)
4 PHE A  74
VAL A  18
SER A  75
GLY A  69
None
0.81A 4m48A-2q34A:
undetectable
4m48A-2q34A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtk PROBABLE PORIN

(Pseudomonas
aeruginosa)
PF03573
(OprD)
4 PHE A 311
VAL A 323
TYR A 307
GLY A 321
None
C8E  A 393 ( 4.4A)
C8E  A 394 ( 3.6A)
C8E  A 393 (-3.7A)
0.76A 4m48A-2qtkA:
undetectable
4m48A-2qtkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE


(Neisseria
gonorrhoeae)
PF00583
(Acetyltransf_1)
PF00696
(AA_kinase)
4 ASP A 350
VAL A 431
SER A 386
ALA A 407
None
0.81A 4m48A-2r98A:
undetectable
4m48A-2r98A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN


(Azospirillum
brasilense)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
4 VAL A 430
ASP A 427
SER A 547
ALA A 557
None
0.85A 4m48A-2vdcA:
undetectable
4m48A-2vdcA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus)
PF03583
(LIP)
4 PHE A 380
SER A 210
GLY A 208
ALA A 354
None
0.91A 4m48A-2veoA:
undetectable
4m48A-2veoA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wns OROTATE
PHOSPHORIBOSYLTRANSF
ERASE


(Homo sapiens)
PF00156
(Pribosyltran)
4 ASP A 154
SER A 128
GLY A 159
ALA A 149
None
OMP  A 450 (-2.5A)
None
None
0.81A 4m48A-2wnsA:
undetectable
4m48A-2wnsA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5n 26S PROTEASOME
REGULATORY SUBUNIT
RPN10


(Schizosaccharomyces
pombe)
PF13519
(VWA_2)
4 ASP A  20
SER A 116
GLY A 145
ALA A  28
None
0.91A 4m48A-2x5nA:
undetectable
4m48A-2x5nA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy ENVELOPE
GLYCOPROTEIN H


(Suid
alphaherpesvirus
1)
PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C)
4 ASP A 618
SER A 580
GLY A 582
ALA A 406
None
0.85A 4m48A-2xqyA:
1.6
4m48A-2xqyA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0h PROBABLE PORIN

(Pseudomonas
aeruginosa)
PF03573
(OprD)
4 TYR A 208
SER A 194
GLY A 182
ALA A 118
None
0.93A 4m48A-2y0hA:
undetectable
4m48A-2y0hA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn DTDP-4-KETO-6-DEOXY-
HEXOSE 3,4-ISOMERASE


(Saccharopolyspora
erythraea)
PF00067
(p450)
4 VAL B 232
ASP B 233
GLY B 373
ALA B 163
None
0.91A 4m48A-2yjnB:
undetectable
4m48A-2yjnB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1


(Sus scrofa)
PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase)
4 ASP A 211
VAL A 200
GLY A 197
ALA A 178
None
0.93A 4m48A-2yn9A:
2.3
4m48A-2yn9A:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypj ENDOGLUCANASE CEL5A

([Eubacterium]
cellulosolvens)
no annotation 5 PHE A 666
VAL A 699
ASP A 633
TYR A 634
ALA A 610
None
1.29A 4m48A-2ypjA:
undetectable
4m48A-2ypjA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9s PEROXIREDOXIN-1

(Rattus
norvegicus)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 ASP A 167
TYR A  38
GLY A  36
ALA A  12
None
0.93A 4m48A-2z9sA:
undetectable
4m48A-2z9sA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI


(Streptococcus
mutans)
PF02324
(Glyco_hydro_70)
4 ASP A 665
TYR A 658
SER A 861
GLY A 859
None
0.85A 4m48A-3aibA:
undetectable
4m48A-3aibA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE


(Thermus
thermophilus)
no annotation 4 ASP E 153
VAL E 229
GLY E 348
ALA E 296
None
0.90A 4m48A-3aoeE:
undetectable
4m48A-3aoeE:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq1 THERMOSOME SUBUNIT

(Methanococcoides
burtonii)
PF00118
(Cpn60_TCP1)
4 ASP B  83
VAL B 470
GLY B 400
ALA B 444
None
0.91A 4m48A-3aq1B:
2.1
4m48A-3aq1B:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbl REGULATORY PROTEIN
OF LACI FAMILY


(Chloroflexus
aggregans)
PF13377
(Peripla_BP_3)
4 PHE A 152
VAL A 198
SER A 130
GLY A 153
None
0.84A 4m48A-3bblA:
undetectable
4m48A-3bblA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN


(Bifidobacterium
longum)
PF02541
(Ppx-GppA)
4 VAL A 220
ASP A 221
GLY A 223
ALA A 216
None
0.90A 4m48A-3cerA:
undetectable
4m48A-3cerA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME


(Schistosoma
japonicum)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 ASP A 101
TYR A 104
GLY A  97
ALA A 158
None
0.73A 4m48A-3cruA:
undetectable
4m48A-3cruA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctk RRNA N-GLYCOSIDASE

(Bougainvillea
spectabilis)
PF00161
(RIP)
4 PHE A 156
VAL A  90
GLY A 112
ALA A  94
None
0.90A 4m48A-3ctkA:
undetectable
4m48A-3ctkA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbk ELASTASE

(Pseudomonas
aeruginosa)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
4 VAL A 137
ASP A 136
GLY A 187
ALA A 113
RDF  A2001 ( 4.2A)
CA  A 303 (-3.7A)
None
RDF  A2001 (-4.3A)
0.82A 4m48A-3dbkA:
undetectable
4m48A-3dbkA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS


(Drosophila
melanogaster)
PF07679
(I-set)
PF13927
(Ig_3)
4 VAL A 290
SER A 293
GLY A 295
ALA A 237
None
0.88A 4m48A-3dmkA:
undetectable
4m48A-3dmkA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7q TRANSCRIPTIONAL
REGULATOR


(Pseudomonas
aeruginosa)
PF00440
(TetR_N)
PF13977
(TetR_C_6)
5 VAL A  62
ASP A  59
SER A  36
GLY A  57
ALA A  65
None
1.43A 4m48A-3e7qA:
undetectable
4m48A-3e7qA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Azotobacter
vinelandii)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 VAL A 294
ASP A 293
SER A 323
GLY A 321
None
0.94A 4m48A-3ekgA:
undetectable
4m48A-3ekgA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger)
PF00723
(Glyco_hydro_15)
4 VAL A 306
ASP A 307
SER A 322
ALA A 348
None
0.92A 4m48A-3eqaA:
2.1
4m48A-3eqaA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fch CARBOXYSOME SHELL
PROTEIN CSOS1D


(Prochlorococcus
marinus)
PF00936
(BMC)
4 VAL A 221
ASP A 220
GLY A 183
ALA A 207
None
0.75A 4m48A-3fchA:
undetectable
4m48A-3fchA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18


(Escherichia
virus T4)
PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
4 ASP A 364
VAL A 370
SER A 367
ALA A  28
None
0.91A 4m48A-3foaA:
undetectable
4m48A-3foaA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fys PROTEIN DEGV

(Bacillus
subtilis)
PF02645
(DegV)
6 ASP A 218
VAL A 254
TYR A 251
SER A 222
GLY A 224
ALA A 229
None
1.35A 4m48A-3fysA:
undetectable
4m48A-3fysA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN


(Geobacter
sulfurreducens)
PF08668
(HDOD)
4 PHE A 247
VAL A 173
ASP A 174
ALA A 183
None
0.79A 4m48A-3hc1A:
undetectable
4m48A-3hc1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgm UNIVERSAL STRESS
PROTEIN TEAD


(Halomonas
elongata)
PF00582
(Usp)
4 ASP A 124
ASP A  10
GLY A  14
ALA A 133
None
ATP  A 148 (-3.5A)
ATP  A 148 ( 4.3A)
ATP  A 148 (-4.1A)
0.92A 4m48A-3hgmA:
undetectable
4m48A-3hgmA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrx PROBABLE ENOYL-COA
HYDRATASE


(Thermus
thermophilus)
PF00378
(ECH_1)
4 PHE A  57
VAL A   2
SER A  58
GLY A  52
None
0.84A 4m48A-3hrxA:
undetectable
4m48A-3hrxA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN


(Streptomyces
coelicolor)
PF01547
(SBP_bac_1)
4 VAL A 393
TYR A 227
GLY A 230
ALA A 398
None
0.91A 4m48A-3i3vA:
undetectable
4m48A-3i3vA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus)
PF00891
(Methyltransf_2)
5 ASP A 147
ASP A 175
SER A 180
GLY A 182
ALA A 243
None
SAH  A 401 ( 4.2A)
None
None
7NA  A 402 ( 3.7A)
1.40A 4m48A-3i58A:
undetectable
4m48A-3i58A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j08 COPPER-EXPORTING
P-TYPE ATPASE A


(Archaeoglobus
fulgidus)
PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase)
4 ASP A 260
VAL A 249
GLY A 246
ALA A 227
None
0.87A 4m48A-3j08A:
undetectable
4m48A-3j08A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A


(Archaeoglobus
fulgidus)
PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase)
4 ASP A 260
VAL A 249
GLY A 246
ALA A 227
None
0.91A 4m48A-3j09A:
undetectable
4m48A-3j09A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18


(Escherichia
virus T4)
PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C)
4 ASP U 364
VAL U 370
SER U 367
ALA U  28
None
0.91A 4m48A-3j2nU:
undetectable
4m48A-3j2nU:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb3 PROTEIN PHOSPHATASE
2C 16


(Arabidopsis
thaliana)
PF00481
(PP2C)
4 VAL B 297
ASP B 298
SER B 327
ALA B 261
None
0.90A 4m48A-3kb3B:
undetectable
4m48A-3kb3B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw3 ALANINE RACEMASE

(Bartonella
henselae)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
4 PHE A 215
VAL A 225
TYR A 221
GLY A 213
None
0.92A 4m48A-3kw3A:
undetectable
4m48A-3kw3A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l88 FIBER PROTEIN

(Human
mastadenovirus
B)
PF00541
(Adeno_knob)
4 VAL A 268
TYR A 259
SER A 262
ALA A 297
None
0.75A 4m48A-3l88A:
undetectable
4m48A-3l88A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhx KETODEOXYGLUCONOKINA
SE


(Shigella
flexneri)
PF00294
(PfkB)
4 PHE A  99
VAL A 145
TYR A 123
ALA A 111
None
0.79A 4m48A-3lhxA:
undetectable
4m48A-3lhxA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lly AGGLUTININ ALPHA
CHAIN


(Maclura
pomifera)
PF01419
(Jacalin)
5 VAL A  80
ASP A 125
TYR A  78
GLY A 121
ALA A  24
None
1.09A 4m48A-3llyA:
undetectable
4m48A-3llyA:
15.04