SIMILAR PATTERNS OF AMINO ACIDS FOR 4M2V_A_BZ1A302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ab6 CHEMOTAXIS PROTEIN
CHEY

(Escherichia
coli) 		PF00072
(Response_reg) 		5 LEU A   9
VAL A  54
GLY A  49
VAL A  83
THR A  71
 None
 0.93A 4m2vA-1ab6A:
undetectable		 4m2vA-1ab6A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fb5 ORNITHINE
TRANSCARBAMOYLASE

(Ovis aries) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 VAL A 142
GLY A  83
VAL A 138
LEU A 151
THR A 150
 None
 0.85A 4m2vA-1fb5A:
undetectable		 4m2vA-1fb5A:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
 0.34A 4m2vA-1jd0A:
36.8		 4m2vA-1jd0A:
36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 GLN A  69
HIS A  92
HIS A  94
LEU A 176
THR A 177
THR A 178
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
 1.07A 4m2vA-1kopA:
29.8		 4m2vA-1kopA:
34.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 GLN A  69
HIS A  94
VAL A 113
LEU A 176
THR A 177
THR A 178
 None
ZN  A 301 ( 3.3A)
None
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
 1.19A 4m2vA-1kopA:
29.8		 4m2vA-1kopA:
34.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		9 GLN A  90
HIS A  92
HIS A  94
VAL A 113
VAL A 123
LEU A 176
THR A 177
THR A 178
TRP A 187
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
None
None
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
 0.34A 4m2vA-1kopA:
29.8		 4m2vA-1kopA:
34.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 LEU A 115
VAL A 123
LEU A 176
THR A 177
THR A 178
TRP A 187
 None
None
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
 1.24A 4m2vA-1kopA:
29.8		 4m2vA-1kopA:
34.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh9 ACETYLGLUTAMATE
KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		5 LEU A 102
VAL A 145
VAL A  41
LEU A 172
THR A 171
 None
 0.88A 4m2vA-1oh9A:
undetectable		 4m2vA-1oh9A:
25.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
 None
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
 1.05A 4m2vA-1rj6A:
37.2		 4m2vA-1rj6A:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
 None
ZN  A 601 (-3.3A)
AZM  A 400 (-4.8A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
 1.12A 4m2vA-1rj6A:
37.2		 4m2vA-1rj6A:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 AZM  A 400 (-4.3A)
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
AZM  A 400 (-4.8A)
None
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
None
 0.36A 4m2vA-1rj6A:
37.2		 4m2vA-1rj6A:
36.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA

(Archaeoglobus
fulgidus) 		PF01008
(IF-2B) 		5 LEU A 151
VAL A 229
GLY A 218
VAL A 253
THR A 312
 None
 0.97A 4m2vA-1t5oA:
undetectable		 4m2vA-1t5oA:
20.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
None
None
ZN  A 280 ( 4.9A)
None
None
 0.29A 4m2vA-1urtA:
37.1		 4m2vA-1urtA:
50.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 HIS A  94
HIS A  96
VAL A 136
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
None
ZN  A 280 ( 4.9A)
None
None
 0.68A 4m2vA-1urtA:
37.1		 4m2vA-1urtA:
50.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 280 (-3.2A)
None
None
ZN  A 280 ( 4.9A)
None
 0.83A 4m2vA-1urtA:
37.1		 4m2vA-1urtA:
50.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		9 GLN A 113
HIS A 115
HIS A 117
VAL A 137
VAL A 153
LEU A 216
THR A 217
THR A 218
TRP A 227
 None
ZN  A 283 ( 3.2A)
ZN  A 283 (-3.2A)
ACY  A 279 ( 4.7A)
None
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
ACY  A 279 ( 4.9A)
None
 0.16A 4m2vA-1y7wA:
26.3		 4m2vA-1y7wA:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		5 HIS A 117
VAL A 137
LEU A 216
THR A 217
THR A 218
 ZN  A 283 (-3.2A)
ACY  A 279 ( 4.7A)
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
ACY  A 279 ( 4.9A)
 0.90A 4m2vA-1y7wA:
26.3		 4m2vA-1y7wA:
31.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c79 GLYCOSIDE HYDROLASE,
FAMILY
11:CLOSTRIDIUM
CELLULOSOME ENZYME,
DOCKERIN TYPE
I:POLYSACCHARIDE

(Ruminiclostridium
thermocellum) 		PF01522
(Polysacc_deac_1) 		6 LEU A 599
VAL A 617
GLY A 624
VAL A 482
LEU A 650
THR A 649
 None
 1.43A 4m2vA-2c79A:
undetectable		 4m2vA-2c79A:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.53A 4m2vA-2it4A:
40.8		 4m2vA-2it4A:
60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00156
(Pribosyltran) 		5 LEU A 138
VAL A  71
GLY A  65
VAL A 100
VAL A 104
 None
None
None
None
CAS  A  82 ( 4.2A)
 0.82A 4m2vA-2jbhA:
undetectable		 4m2vA-2jbhA:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A 118
VAL A 157
LEU A 222
THR A 223
TRP A 233
 CL  A 401 (-4.2A)
None
None
CL  A 401 ( 4.8A)
None
 0.43A 4m2vA-2w2jA:
37.4		 4m2vA-2w2jA:
38.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625

(Thermus
thermophilus) 		PF13277
(YmdB) 		5 LEU A  86
VAL A 112
VAL A 140
VAL A 144
LEU A 159
 None
 0.91A 4m2vA-2z06A:
undetectable		 4m2vA-2z06A:
24.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
None
None
None
ZN  A   1 ( 4.7A)
None
None
 0.30A 4m2vA-2zncA:
32.5		 4m2vA-2zncA:
35.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A   1 ( 3.3A)
None
None
ZN  A   1 ( 4.7A)
None
 0.86A 4m2vA-2zncA:
32.5		 4m2vA-2zncA:
35.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 GLN A 115
HIS A 163
HIS A 165
LEU A 259
THR A 260
THR A 261
 None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
None
ZN  A 378 ( 4.5A)
None
 1.03A 4m2vA-3b1bA:
25.0		 4m2vA-3b1bA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 GLN A 115
HIS A 165
VAL A 184
LEU A 259
THR A 260
THR A 261
 None
ZN  A 378 (-3.3A)
None
None
ZN  A 378 ( 4.5A)
None
 1.14A 4m2vA-3b1bA:
25.0		 4m2vA-3b1bA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 GLN A 161
HIS A 163
HIS A 165
VAL A 184
GLY A 197
LEU A 259
THR A 260
 None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
None
None
None
ZN  A 378 ( 4.5A)
 1.36A 4m2vA-3b1bA:
25.0		 4m2vA-3b1bA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		9 GLN A 161
HIS A 163
HIS A 165
VAL A 184
VAL A 201
LEU A 259
THR A 260
THR A 261
TRP A 270
 None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
None
None
None
ZN  A 378 ( 4.5A)
None
None
 0.23A 4m2vA-3b1bA:
25.0		 4m2vA-3b1bA:
26.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  93
HIS A  95
HIS A  97
VAL A 122
LEU A 199
THR A 200
 4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
 0.92A 4m2vA-3da2A:
42.3		 4m2vA-3da2A:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A  95
HIS A  97
VAL A 122
VAL A 144
LEU A 199
THR A 200
TRP A 210
 ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
 0.43A 4m2vA-3da2A:
42.3		 4m2vA-3da2A:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A 109
HIS A 111
HIS A 113
VAL A 140
VAL A 161
LEU A 219
THR A 220
TRP A 230
 None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
None
 0.62A 4m2vA-3fe4A:
31.7		 4m2vA-3fe4A:
34.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A 111
HIS A 113
VAL A 140
VAL A 161
LEU A 219
THR A 220
 MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
 1.48A 4m2vA-3fe4A:
31.7		 4m2vA-3fe4A:
34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A 129
VAL A 170
LEU A 235
THR A 236
TRP A 246
 None
 0.72A 4m2vA-3jxfA:
33.7		 4m2vA-3jxfA:
29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kie CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		5 LEU A 354
GLN A 646
VAL A 353
GLY A 360
THR A 277
 None
 0.88A 4m2vA-3kieA:
undetectable		 4m2vA-3kieA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2h PUTATIVE SUGAR
PHOSPHATE ISOMERASE

(Acidithiobacillus
ferrooxidans) 		PF07883
(Cupin_2) 		6 HIS A 104
HIS A  62
VAL A  71
GLY A  76
VAL A 118
THR A  59
 EDO  A 167 (-4.0A)
EDO  A 167 (-4.2A)
None
None
EDO  A 167 ( 4.9A)
EDO  A 167 ( 3.9A)
 1.19A 4m2vA-3l2hA:
undetectable		 4m2vA-3l2hA:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
 None
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
 1.20A 4m2vA-3ml5A:
43.1		 4m2vA-3ml5A:
56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
VAL A 121
GLY A 132
LEU A 198
THR A 199
 AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
None
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
 1.40A 4m2vA-3ml5A:
43.1		 4m2vA-3ml5A:
56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		10 GLN A  92
HIS A  94
HIS A  96
VAL A 121
GLY A 132
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
None
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
 0.30A 4m2vA-3ml5A:
43.1		 4m2vA-3ml5A:
56.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng9 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		5 LEU A 355
GLN A 646
VAL A 354
GLY A 361
THR A 278
 None
 0.94A 4m2vA-3ng9A:
undetectable		 4m2vA-3ng9A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow8 WD REPEAT-CONTAINING
PROTEIN 61

(Homo sapiens) 		PF00400
(WD40) 		5 LEU A 204
HIS A 189
VAL A 206
GLY A 262
LEU A 228
 None
 0.97A 4m2vA-3ow8A:
undetectable		 4m2vA-3ow8A:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		6 GLN A 121
HIS A 123
HIS A 125
VAL A 144
LEU A 214
THR A 215
 MLT  A   3 (-3.9A)
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
None
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
 1.45A 4m2vA-3q31A:
24.5		 4m2vA-3q31A:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		9 GLN A 121
HIS A 123
HIS A 125
VAL A 144
VAL A 154
LEU A 214
THR A 215
THR A 216
TRP A 225
 MLT  A   3 (-3.9A)
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
None
MLT  A   3 (-4.6A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
MLT  A   3 (-4.9A)
 0.36A 4m2vA-3q31A:
24.5		 4m2vA-3q31A:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		6 HIS A 123
VAL A 154
LEU A 214
THR A 215
THR A 216
TRP A 225
 ZN  A   1 ( 3.2A)
MLT  A   3 (-4.6A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
MLT  A   3 (-4.9A)
 1.36A 4m2vA-3q31A:
24.5		 4m2vA-3q31A:
31.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		5 LEU A 357
GLN A 648
VAL A 356
GLY A 363
THR A 280
 None
 0.94A 4m2vA-3ra2A:
undetectable		 4m2vA-3ra2A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		5 LEU A 355
GLN A 646
VAL A 354
GLY A 361
THR A 278
 None
 0.88A 4m2vA-3shmA:
undetectable		 4m2vA-3shmA:
18.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 142
THR A 198
 None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
 1.25A 4m2vA-3uyqA:
41.4		 4m2vA-3uyqA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 142
THR A 198
THR A 199
TRP A 208
 None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
None
None
 0.38A 4m2vA-3uyqA:
41.4		 4m2vA-3uyqA:
57.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1

(Cyanidioschyzon
merolae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 VAL A 639
GLY A 483
VAL A 474
LEU A 466
THR A 467
 None
 0.87A 4m2vA-3wmeA:
undetectable		 4m2vA-3wmeA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3v E1 ENVELOPE
GLYCOPROTEIN

(Rubella virus) 		PF05748
(Rubella_E1) 		5 LEU A 370
VAL A 377
VAL A 346
LEU A 391
THR A 393
 None
 0.97A 4m2vA-4b3vA:
undetectable		 4m2vA-4b3vA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  91
VAL A 110
LEU A 173
THR A 174
THR A 175
 None
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.7A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
 1.25A 4m2vA-4g7aA:
30.1		 4m2vA-4g7aA:
34.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		8 GLN A  87
HIS A  89
HIS A  91
VAL A 110
GLY A 116
LEU A 173
THR A 174
THR A 175
 AZM  A 302 (-4.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.7A)
None
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
 1.21A 4m2vA-4g7aA:
30.1		 4m2vA-4g7aA:
34.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		9 GLN A  87
HIS A  89
HIS A  91
VAL A 110
VAL A 120
LEU A 173
THR A 174
THR A 175
TRP A 184
 AZM  A 302 (-4.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.7A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
None
 0.24A 4m2vA-4g7aA:
30.1		 4m2vA-4g7aA:
34.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		11 GLN A  92
HIS A  94
HIS A  96
VAL A 121
GLY A 132
VAL A 135
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
None
None
ZN  A 301 ( 4.4A)
None
None
 0.22A 4m2vA-4qk3A:
43.8		 4m2vA-4qk3A:
92.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 135
LEU A 198
THR A 199
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 ( 4.4A)
 1.43A 4m2vA-4qk3A:
43.8		 4m2vA-4qk3A:
92.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
 ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
 0.89A 4m2vA-4qk3A:
43.8		 4m2vA-4qk3A:
92.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  96
VAL A 143
VAL A 135
LEU A 198
THR A 200
 ZN  A 301 (-3.2A)
None
None
None
None
 0.93A 4m2vA-4qk3A:
43.8		 4m2vA-4qk3A:
92.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twl DIOSCORIN 5

(Dioscorea
japonica) 		PF00194
(Carb_anhydrase) 		5 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 4m2vA-4twlA:
28.6		 4m2vA-4twlA:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		7 GLN A 110
HIS A 112
HIS A 114
VAL A 133
GLY A 139
LEU A 197
THR A 198
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
PEG  A 305 ( 4.5A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.23A 4m2vA-4uovA:
31.5		 4m2vA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		9 GLN A 110
HIS A 112
HIS A 114
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.30A 4m2vA-4uovA:
31.5		 4m2vA-4uovA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		6 LEU A 135
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 PEG  A 305 (-4.3A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.15A 4m2vA-4uovA:
31.5		 4m2vA-4uovA:
40.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD

(Mycolicibacterium
smegmatis) 		PF10017
(Methyltransf_33) 		5 LEU A 189
HIS A 151
VAL A 157
VAL A  83
LEU A 146
 None
 0.97A 4m2vA-4uy6A:
undetectable		 4m2vA-4uy6A:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  91
VAL A 110
LEU A 173
THR A 174
THR A 175
 None
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
 1.23A 4m2vA-4x5sA:
30.0		 4m2vA-4x5sA:
38.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		8 GLN A  87
HIS A  89
HIS A  91
VAL A 110
GLY A 116
LEU A 173
THR A 174
THR A 175
 AZM  A 302 (-4.3A)
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
None
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
 1.13A 4m2vA-4x5sA:
30.0		 4m2vA-4x5sA:
38.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		9 GLN A  87
HIS A  89
HIS A  91
VAL A 110
VAL A 120
LEU A 173
THR A 174
THR A 175
TRP A 184
 AZM  A 302 (-4.3A)
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
 0.26A 4m2vA-4x5sA:
30.0		 4m2vA-4x5sA:
38.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		6 HIS A  89
HIS A  91
VAL A 120
GLY A 116
LEU A 173
THR A 175
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
None
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
 1.12A 4m2vA-4x5sA:
30.0		 4m2vA-4x5sA:
38.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		6 HIS A  89
HIS A  91
VAL A 120
GLY A 116
LEU A 173
THR A 175
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
None
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
 1.44A 4m2vA-4x5sA:
30.0		 4m2vA-4x5sA:
38.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		6 HIS A 110
HIS A 112
VAL A 131
GLY A 137
LEU A 190
THR A 191
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
None
None
None
ZN  A 301 (-4.3A)
 1.34A 4m2vA-4xfwA:
26.7		 4m2vA-4xfwA:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		7 HIS A 110
HIS A 112
VAL A 131
VAL A 141
LEU A 190
THR A 191
TRP A 201
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
None
None
None
ZN  A 301 (-4.3A)
None
 0.45A 4m2vA-4xfwA:
26.7		 4m2vA-4xfwA:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 GLN A 138
HIS A 162
VAL A 181
LEU A 253
THR A 254
THR A 255
 None
ZN  A 401 ( 3.2A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
 1.04A 4m2vA-4xixA:
25.9		 4m2vA-4xixA:
35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 LEU A 157
GLN A 158
HIS A 160
HIS A 162
VAL A 181
LEU A 253
THR A 255
 None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-3.6A)
 1.45A 4m2vA-4xixA:
25.9		 4m2vA-4xixA:
35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		10 LEU A 157
GLN A 158
HIS A 160
HIS A 162
VAL A 181
VAL A 192
LEU A 253
THR A 254
THR A 255
TRP A 264
 None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
None
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
 0.64A 4m2vA-4xixA:
25.9		 4m2vA-4xixA:
35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 HIS A 165
VAL A 196
LEU A 251
THR A 252
THR A 253
TRP A 262
 ZN  A 401 ( 3.2A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
 1.40A 4m2vA-4xz5A:
29.9		 4m2vA-4xz5A:
33.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 HIS A 167
VAL A 196
GLY A 192
LEU A 251
THR A 252
THR A 253
 ZN  A 401 ( 3.3A)
None
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
 1.00A 4m2vA-4xz5A:
29.9		 4m2vA-4xz5A:
33.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		9 LEU A 162
GLN A 163
HIS A 165
HIS A 167
VAL A 186
GLY A 192
LEU A 251
THR A 252
THR A 253
 None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
None
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
 1.24A 4m2vA-4xz5A:
29.9		 4m2vA-4xz5A:
33.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		10 LEU A 162
GLN A 163
HIS A 165
HIS A 167
VAL A 186
VAL A 196
LEU A 251
THR A 252
THR A 253
TRP A 262
 None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
None
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
 0.60A 4m2vA-4xz5A:
29.9		 4m2vA-4xz5A:
33.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		5 LEU A  96
VAL A 128
GLY A 238
VAL A 167
THR A  41
 None
None
PO4  A 303 (-3.3A)
None
None
 0.91A 4m2vA-4y96A:
undetectable		 4m2vA-4y96A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		6 LEU A 116
VAL A  77
GLY A 153
VAL A 157
LEU A  94
THR A  95
 None
 1.35A 4m2vA-5bxpA:
undetectable		 4m2vA-5bxpA:
18.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
 GOL  A 303 (-3.4A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
 1.15A 4m2vA-5cjfA:
36.9		 4m2vA-5cjfA:
38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
 0.20A 4m2vA-5cjfA:
36.9		 4m2vA-5cjfA:
38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 LEU A 131
HIS A  94
HIS A  96
VAL A 143
THR A 200
TRP A 209
 520  A 302 ( 4.8A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
GOL  A 303 ( 3.5A)
None
 1.00A 4m2vA-5cjfA:
36.9		 4m2vA-5cjfA:
38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A 151
LEU A 256
THR A 257
THR A 258
TRP A 267
 None
 0.30A 4m2vA-5e5uA:
34.3		 4m2vA-5e5uA:
31.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5er3 SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13407
(Peripla_BP_4) 		5 LEU A  99
GLY A 109
LEU A  78
THR A  76
THR A  77
 None
 0.85A 4m2vA-5er3A:
undetectable		 4m2vA-5er3A:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		10 GLN X  91
HIS X  93
HIS X  95
VAL X 120
GLY X 130
VAL X 141
LEU X 196
THR X 197
THR X 198
TRP X 207
 None
ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
None
None
None
None
ZN  X 301 ( 4.4A)
None
None
 0.26A 4m2vA-5eztX:
44.0		 4m2vA-5eztX:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		5 HIS X  95
VAL X 120
LEU X 196
THR X 197
THR X 198
 ZN  X 301 (-3.2A)
None
None
ZN  X 301 ( 4.4A)
None
 0.94A 4m2vA-5eztX:
44.0		 4m2vA-5eztX:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		8 GLN A  94
HIS A  96
HIS A  98
VAL A 117
GLY A 123
LEU A 181
THR A 182
THR A 183
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 ( 4.4A)
None
 1.05A 4m2vA-5hpjA:
29.4		 4m2vA-5hpjA:
34.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		6 GLN A  94
HIS A  96
HIS A  98
VAL A 117
LEU A 181
THR A 182
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
 1.50A 4m2vA-5hpjA:
29.4		 4m2vA-5hpjA:
34.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		9 GLN A  94
HIS A  96
HIS A  98
VAL A 117
VAL A 127
LEU A 181
THR A 182
THR A 183
TRP A 192
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 ( 4.4A)
None
None
 0.39A 4m2vA-5hpjA:
29.4		 4m2vA-5hpjA:
34.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		5 HIS A  98
VAL A 117
LEU A 181
THR A 182
THR A 183
 ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
 0.98A 4m2vA-5hpjA:
29.4		 4m2vA-5hpjA:
34.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		5 HIS A  98
VAL A 127
GLY A 123
LEU A 181
THR A 183
 ZN  A 301 (-3.2A)
None
None
None
None
 0.91A 4m2vA-5hpjA:
29.4		 4m2vA-5hpjA:
34.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
 EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
 1.44A 4m2vA-5jn9A:
33.5		 4m2vA-5jn9A:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
 0.33A 4m2vA-5jn9A:
33.5		 4m2vA-5jn9A:
36.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uw8 PROBABLE
PHOSPHOLIPID ABC
TRANSPORTER-BINDING
PROTEIN MLAD

(Escherichia
coli) 		PF02470
(MlaD) 		5 VAL A  82
GLY A  66
VAL A  58
LEU A  99
THR A 137
 None
 0.96A 4m2vA-5uw8A:
undetectable		 4m2vA-5uw8A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgi ANOCTAMIN-1

(Mus musculus) 		no annotation 5 LEU A 643
GLY A 707
VAL A 709
LEU A 342
THR A 339
 CA  A1002 (-3.6A)
None
None
None
None
 0.97A 4m2vA-6bgiA:
undetectable		 4m2vA-6bgiA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP

(Streptomyces
wadayamensis) 		no annotation 5 VAL A 298
GLY A 319
VAL A 322
VAL A 295
LEU A 369
 None
 0.97A 4m2vA-6c9bA:
undetectable		 4m2vA-6c9bA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d47 BETA SLIDING CLAMP

(Mycobacterium
marinum) 		no annotation 5 LEU A 178
VAL A 169
GLY A 212
VAL A 204
LEU A 240
 None
 0.96A 4m2vA-6d47A:
undetectable		 4m2vA-6d47A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 8 GLN A 115
HIS A 117
HIS A 119
VAL A 138
GLY A 144
LEU A 201
THR A 202
THR A 203
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
None
None
ZN  A 301 (-4.4A)
None
 1.15A 4m2vA-6ekiA:
30.0		 4m2vA-6ekiA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 9 GLN A 115
HIS A 117
HIS A 119
VAL A 138
VAL A 148
LEU A 201
THR A 202
THR A 203
TRP A 212
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
None
None
ZN  A 301 (-4.4A)
None
None
 0.22A 4m2vA-6ekiA:
30.0		 4m2vA-6ekiA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 5 HIS A 119
VAL A 138
LEU A 201
THR A 202
THR A 203
 ZN  A 301 (-3.3A)
None
None
ZN  A 301 (-4.4A)
None
 0.87A 4m2vA-6ekiA:
30.0		 4m2vA-6ekiA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 5 HIS A 119
VAL A 148
GLY A 144
LEU A 201
THR A 203
 ZN  A 301 (-3.3A)
None
None
None
None
 0.99A 4m2vA-6ekiA:
30.0		 4m2vA-6ekiA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 10 LEU A  91
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.7A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
 0.59A 4m2vA-6fe1A:
34.2		 4m2vA-6fe1A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE

(Arthrobacter
sp. 1C) 		PF02317
(Octopine_DH)
PF02558
(ApbA) 		3 HIS A  88
VAL A  73
LEU A  10
 None
 0.76A 4m2vA-1bg6A:
0.0		 4m2vA-1bg6A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bnl COLLAGEN XVIII

(Homo sapiens) 		PF06482
(Endostatin) 		3 HIS A 121
VAL A 108
LEU A 152
 None
 0.76A 4m2vA-1bnlA:
0.0		 4m2vA-1bnlA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		3 HIS A 265
VAL A  43
LEU A  47
 None
 0.74A 4m2vA-1cj0A:
0.0		 4m2vA-1cj0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyq INTRON-ENCODED
HOMING ENDONUCLEASE
I-PPOI

(Physarum
polycephalum) 		no annotation 3 HIS A  78
VAL A 136
LEU A  99
 None
 0.69A 4m2vA-1cyqA:
0.0		 4m2vA-1cyqA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		3 HIS A  34
VAL A  52
LEU A  28
 None
 0.72A 4m2vA-1d9zA:
0.0		 4m2vA-1d9zA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkt CYCLIN DEPENDENT
KINASE SUBUNIT, TYPE
1

(Homo sapiens) 		PF01111
(CKS) 		3 HIS A  60
VAL A  48
LEU A  24
 None
 0.77A 4m2vA-1dktA:
undetectable		 4m2vA-1dktA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5r PROLINE OXIDASE

(Streptomyces
sp. TH1) 		PF05118
(Asp_Arg_Hydrox)
PF05373
(Pro_3_hydrox_C) 		3 HIS A  43
VAL A  82
LEU A 171
 None
 0.65A 4m2vA-1e5rA:
0.0		 4m2vA-1e5rA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1e HISTONE FOLD PROTEIN

(Methanopyrus
kandleri) 		PF00808
(CBFD_NFYB_HMF) 		3 HIS A  62
VAL A  75
LEU A 107
 None
 0.68A 4m2vA-1f1eA:
undetectable		 4m2vA-1f1eA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		3 HIS A  40
VAL A  85
LEU A  65
 None
 0.71A 4m2vA-1fizA:
0.0		 4m2vA-1fizA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		3 HIS A 416
VAL A 440
LEU A 421
 None
 0.77A 4m2vA-1fohA:
0.0		 4m2vA-1fohA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g29 MALTOSE TRANSPORT
PROTEIN MALK

(Thermococcus
litoralis) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 HIS 1  95
VAL 1 148
LEU 1  92
 None
 0.66A 4m2vA-1g291:
undetectable		 4m2vA-1g291:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm6 SALIVARY LIPOCALIN

(Sus scrofa) 		PF00061
(Lipocalin) 		3 HIS A 107
VAL A  43
LEU A  27
 None
 0.77A 4m2vA-1gm6A:
undetectable		 4m2vA-1gm6A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		3 HIS S  42
VAL S  68
LEU S  61
 None
 0.67A 4m2vA-1i84S:
undetectable		 4m2vA-1i84S:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iw8 ACID PHOSPHATASE

(Shimwellia
blattae) 		PF01569
(PAP2) 		3 HIS A 117
VAL A 200
LEU A  31
 None
 0.71A 4m2vA-1iw8A:
undetectable		 4m2vA-1iw8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		3 HIS A  39
VAL A  25
LEU A  36
 None
 0.57A 4m2vA-1j3bA:
undetectable		 4m2vA-1j3bA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lg7 VSV MATRIX PROTEIN

(Vesicular
stomatitis
virus) 		PF06326
(Vesiculo_matrix) 		3 HIS A 134
VAL A  88
LEU A 173
 CSO  A 135 ( 4.4A)
None
None
 0.54A 4m2vA-1lg7A:
undetectable		 4m2vA-1lg7A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ly7 FRATAXIN

(Homo sapiens) 		PF01491
(Frataxin_Cyay) 		3 HIS A 183
VAL A 125
LEU A 132
 None
 0.61A 4m2vA-1ly7A:
undetectable		 4m2vA-1ly7A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		3 HIS A 454
VAL A 421
LEU A 429
 None
 0.74A 4m2vA-1m7jA:
undetectable		 4m2vA-1m7jA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg5 ALCOHOL
DEHYDROGENASE

(Drosophila
melanogaster) 		PF00106
(adh_short) 		3 HIS A 191
VAL A 149
LEU A  96
 None
 0.64A 4m2vA-1mg5A:
undetectable		 4m2vA-1mg5A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1j HEMOGLOBIN ALPHA
CHAIN

(Homo sapiens) 		PF00042
(Globin) 		3 HIS A 122
VAL A  17
LEU A 113
 None
 0.70A 4m2vA-1o1jA:
undetectable		 4m2vA-1o1jA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 HIS A 627
VAL A 761
LEU A 741
 None
 0.69A 4m2vA-1ofeA:
undetectable		 4m2vA-1ofeA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		3 HIS A 262
VAL A 231
LEU A 259
 None
 0.77A 4m2vA-1pemA:
undetectable		 4m2vA-1pemA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		3 HIS A 285
VAL A 407
LEU A 292
 None
 0.77A 4m2vA-1py5A:
undetectable		 4m2vA-1py5A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5m SIR4-INTERACTING
PROTEIN SIF2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 HIS A 387
VAL A 415
LEU A 429
 None
 0.77A 4m2vA-1r5mA:
undetectable		 4m2vA-1r5mA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 HIS A 513
VAL A 526
LEU A 522
 None
 0.76A 4m2vA-1r8wA:
undetectable		 4m2vA-1r8wA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szp DNA REPAIR PROTEIN
RAD51

(Saccharomyces
cerevisiae) 		PF08423
(Rad51)
PF14520
(HHH_5) 		3 HIS A 352
VAL A 282
LEU A 303
 None
 0.76A 4m2vA-1szpA:
undetectable		 4m2vA-1szpA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta9 GLYCEROL
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00465
(Fe-ADH) 		3 HIS A 366
VAL A 294
LEU A 226
 None
 0.70A 4m2vA-1ta9A:
undetectable		 4m2vA-1ta9A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		3 HIS A 217
VAL A 208
LEU A 230
 None
 0.75A 4m2vA-1tjrA:
undetectable		 4m2vA-1tjrA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0j DNA REPLICATION
PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF01057
(Parvo_NS1) 		3 HIS A 437
VAL A 418
LEU A 394
 None
 0.70A 4m2vA-1u0jA:
undetectable		 4m2vA-1u0jA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 HIS A 473
VAL A 467
LEU A 469
 None
 0.77A 4m2vA-1u59A:
undetectable		 4m2vA-1u59A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4u HEMOGLOBIN ALPHA
CHAIN

(Thunnus thynnus) 		PF00042
(Globin) 		3 HIS A 105
VAL A  68
LEU A 131
 None
 0.77A 4m2vA-1v4uA:
undetectable		 4m2vA-1v4uA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		3 HIS A 411
VAL A 193
LEU A 420
 None
 0.68A 4m2vA-1vb3A:
undetectable		 4m2vA-1vb3A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vch PHOSPHORIBOSYLTRANSF
ERASE-RELATED
PROTEIN

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		3 HIS A  68
VAL A  49
LEU A  56
 None
 0.74A 4m2vA-1vchA:
undetectable		 4m2vA-1vchA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG

(Mus musculus) 		PF00225
(Kinesin) 		3 HIS A 218
VAL A 178
LEU A 314
 None
 0.77A 4m2vA-1vfwA:
undetectable		 4m2vA-1vfwA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjz ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		3 HIS A 131
VAL A 194
LEU A 172
 None
 0.65A 4m2vA-1vjzA:
undetectable		 4m2vA-1vjzA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqv THIAMINE
MONOPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00586
(AIRS) 		3 HIS A 218
VAL A 151
LEU A 265
 None
 0.60A 4m2vA-1vqvA:
undetectable		 4m2vA-1vqvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		3 HIS A 403
VAL A  85
LEU A 396
 None
 0.64A 4m2vA-1w6jA:
undetectable		 4m2vA-1w6jA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 HIS A 301
VAL A 386
LEU A 298
 None
 0.73A 4m2vA-1xfdA:
undetectable		 4m2vA-1xfdA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 3 HIS B  79
VAL B  55
LEU B 220
 None
 0.72A 4m2vA-1xnjB:
undetectable		 4m2vA-1xnjB:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT

(Streptomyces
coelicolor) 		PF01039
(Carboxyl_trans) 		3 HIS A 505
VAL A 334
LEU A 510
 None
 0.75A 4m2vA-1xnyA:
undetectable		 4m2vA-1xnyA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xte SERINE/THREONINE-PRO
TEIN KINASE SGK3

(Mus musculus) 		PF00787
(PX) 		3 HIS A 104
VAL A  10
LEU A 111
 None
 0.58A 4m2vA-1xteA:
undetectable		 4m2vA-1xteA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtn SERINE/THREONINE-PRO
TEIN KINASE SGK3

(Mus musculus) 		PF00787
(PX) 		3 HIS A 104
VAL A  10
LEU A 111
 None
 0.57A 4m2vA-1xtnA:
undetectable		 4m2vA-1xtnA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc6 COAT PROTEIN

(Brome mosaic
virus) 		no annotation 3 HIS A 175
VAL A 108
LEU A 171
 None
 0.77A 4m2vA-1yc6A:
undetectable		 4m2vA-1yc6A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylf RRF2 FAMILY PROTEIN

(Bacillus cereus) 		PF02082
(Rrf2) 		3 HIS A  15
VAL A  57
LEU A  20
 None
 0.72A 4m2vA-1ylfA:
undetectable		 4m2vA-1ylfA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 HIS A 220
VAL A 273
LEU A 241
 None
 0.76A 4m2vA-1zj9A:
undetectable		 4m2vA-1zj9A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN

(Neisseria
meningitidis) 		PF00359
(PTS_EIIA_2) 		3 HIS A  12
VAL A 116
LEU A 103
 None
 0.76A 4m2vA-2a0jA:
undetectable		 4m2vA-2a0jA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2f EXOCYST COMPLEX
COMPONENT SEC15

(Drosophila
melanogaster) 		PF04091
(Sec15) 		3 HIS X 179
VAL X  80
LEU X 149
 None
 0.74A 4m2vA-2a2fX:
undetectable		 4m2vA-2a2fX:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a35 HYPOTHETICAL PROTEIN
PA4017

(Pseudomonas
aeruginosa) 		PF08732
(HIM1) 		3 HIS A 178
VAL A 112
LEU A 161
 None
 0.74A 4m2vA-2a35A:
undetectable		 4m2vA-2a35A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		3 HIS A 190
VAL A 286
LEU A 222
 None
 0.49A 4m2vA-2amcA:
undetectable		 4m2vA-2amcA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2apj PUTATIVE ESTERASE

(Arabidopsis
thaliana) 		PF03629
(SASA) 		3 HIS A 186
VAL A 155
LEU A 193
 None
 0.75A 4m2vA-2apjA:
undetectable		 4m2vA-2apjA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azw MUTT/NUDIX FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00293
(NUDIX) 		3 HIS A 120
VAL A 140
LEU A 131
 None
 0.74A 4m2vA-2azwA:
undetectable		 4m2vA-2azwA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5i CYTOKINE RECEPTOR
COMMON GAMMA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		3 HIS C  82
VAL C 108
LEU C  65
 None
 0.76A 4m2vA-2b5iC:
undetectable		 4m2vA-2b5iC:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3n GLUTATHIONE
S-TRANSFERASE THETA
1

(Homo sapiens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 HIS A 116
VAL A 184
LEU A 140
 None
 0.75A 4m2vA-2c3nA:
undetectable		 4m2vA-2c3nA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 HIS A  56
VAL A 162
LEU A  61
 None
 0.65A 4m2vA-2csdA:
undetectable		 4m2vA-2csdA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0i DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 HIS A 216
VAL A 204
LEU A 206
 None
 0.75A 4m2vA-2d0iA:
undetectable		 4m2vA-2d0iA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE

(Acidithiobacillus
thiooxidans) 		PF00180
(Iso_dh) 		3 HIS A 379
VAL A 150
LEU A 128
 None
 0.74A 4m2vA-2d4vA:
undetectable		 4m2vA-2d4vA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbr GLYOXYLATE REDUCTASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 HIS A 220
VAL A 208
LEU A 210
 None
 0.72A 4m2vA-2dbrA:
undetectable		 4m2vA-2dbrA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkt RING FINGER AND CHY
ZINC FINGER
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF05495
(zf-CHY) 		3 HIS A  21
VAL A  56
LEU A  51
 ZN  A 191 (-3.1A)
None
None
 0.68A 4m2vA-2dktA:
undetectable		 4m2vA-2dktA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dm8 INAD-LIKE PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		3 HIS A  81
VAL A  74
LEU A  76
 None
 0.67A 4m2vA-2dm8A:
undetectable		 4m2vA-2dm8A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvk UPF0130 PROTEIN
APE0816

(Aeropyrum
pernix) 		PF02676
(TYW3) 		3 HIS A  52
VAL A  76
LEU A  84
 None
 0.64A 4m2vA-2dvkA:
undetectable		 4m2vA-2dvkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e47 TIME INTERVAL
MEASURING ENZYME
TIME

(Bombyx mori) 		PF00080
(Sod_Cu) 		3 HIS A  34
VAL A  51
LEU A  88
 None
 0.75A 4m2vA-2e47A:
undetectable		 4m2vA-2e47A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eeg PDZ AND LIM DOMAIN
PROTEIN 4

(Homo sapiens) 		PF00595
(PDZ) 		3 HIS A  40
VAL A  12
LEU A  14
 None
 0.66A 4m2vA-2eegA:
undetectable		 4m2vA-2eegA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B

(Homo sapiens) 		PF14580
(LRR_9) 		3 HIS A  99
VAL A 142
LEU A 149
 None
 0.75A 4m2vA-2ellA:
undetectable		 4m2vA-2ellA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f00 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 HIS A 271
VAL A 301
LEU A 318
 None
 0.77A 4m2vA-2f00A:
undetectable		 4m2vA-2f00A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf4 PROTEIN VNG1086C

(Halobacterium
salinarum) 		PF01893
(UPF0058) 		3 HIS A  53
VAL A  14
LEU A  58
 None
 0.74A 4m2vA-2gf4A:
undetectable		 4m2vA-2gf4A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggt SCO1 PROTEIN
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF02630
(SCO1-SenC) 		3 HIS A 145
VAL A 234
LEU A 142
 None
 0.57A 4m2vA-2ggtA:
undetectable		 4m2vA-2ggtA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpr GLUCOSE-PERMEASE IIA
COMPONENT

(Mycoplasma
capricolum) 		PF00358
(PTS_EIIA_1) 		3 HIS A  68
VAL A  29
LEU A  86
 None
 0.77A 4m2vA-2gprA:
undetectable		 4m2vA-2gprA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqt UDP-N-ACETYLENOLPYRU
VYLGLUCOSAMINE
REDUCTASE

(Thermus
caldophilus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		3 HIS A 139
VAL A 112
LEU A 155
 None
 0.57A 4m2vA-2gqtA:
undetectable		 4m2vA-2gqtA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		3 HIS A 238
VAL A 229
LEU A 270
 None
 0.71A 4m2vA-2gzsA:
undetectable		 4m2vA-2gzsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 HIS A 155
VAL A 418
LEU A 161
 None
 0.70A 4m2vA-2h88A:
undetectable		 4m2vA-2h88A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Aquifex
aeolicus) 		PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C) 		3 HIS A 127
VAL A 143
LEU A  79
 ACP  A 700 (-3.9A)
None
None
 0.62A 4m2vA-2hcbA:
undetectable		 4m2vA-2hcbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxd DCTP DEAMINASE,
DUMP-FORMING

(Methanocaldococcus
jannaschii) 		PF00692
(dUTPase) 		3 HIS A 128
VAL A  67
LEU A 125
 None
 0.75A 4m2vA-2hxdA:
undetectable		 4m2vA-2hxdA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyp HYPOTHETICAL PROTEIN
RV0805

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		3 HIS A  23
VAL A  80
LEU A  41
 FE  A 444 ( 3.4A)
None
None
 0.70A 4m2vA-2hypA:
undetectable		 4m2vA-2hypA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 HIS A 463
VAL A 266
LEU A 469
 None
 0.64A 4m2vA-2i6tA:
undetectable		 4m2vA-2i6tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijx DNA POLYMERASE
SLIDING CLAMP A

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 HIS A  43
VAL A 204
LEU A  21
 None
 0.71A 4m2vA-2ijxA:
undetectable		 4m2vA-2ijxA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0u ATP-DEPENDENT RNA
HELICASE DDX48

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 HIS A 138
VAL A  96
LEU A 126
 None
 0.61A 4m2vA-2j0uA:
undetectable		 4m2vA-2j0uA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jan TYROSYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00579
(tRNA-synt_1b) 		3 HIS A  65
VAL A 221
LEU A 219
 None
 0.62A 4m2vA-2janA:
undetectable		 4m2vA-2janA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kk1 TYROSINE-PROTEIN
KINASE ABL2

(Homo sapiens) 		PF08919
(F_actin_bind) 		3 HIS A  67
VAL A 126
LEU A  96
 None
 0.72A 4m2vA-2kk1A:
undetectable		 4m2vA-2kk1A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m7z CD63-LIKE PROTEIN
SM-TSP-2

(Schistosoma
mansoni) 		PF00335
(Tetraspannin) 		3 HIS A  11
VAL A  32
LEU A  19
 None
 0.73A 4m2vA-2m7zA:
undetectable		 4m2vA-2m7zA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzv CYSTATIN

(Sesamum indicum) 		PF16845
(SQAPI) 		3 HIS A 117
VAL A 178
LEU A 165
 None
 0.72A 4m2vA-2mzvA:
undetectable		 4m2vA-2mzvA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrx UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		3 HIS A 469
VAL A 481
LEU A 454
 None
 0.74A 4m2vA-2nrxA:
undetectable		 4m2vA-2nrxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 HIS A 384
VAL A 350
LEU A 336
 None
 0.69A 4m2vA-2okcA:
undetectable		 4m2vA-2okcA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ol5 PAI 2 PROTEIN

(Geobacillus
stearothermophilus) 		PF04299
(FMN_bind_2) 		3 HIS A  54
VAL A  70
LEU A  27
 None
 0.74A 4m2vA-2ol5A:
undetectable		 4m2vA-2ol5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C

(Neurospora
crassa) 		PF00225
(Kinesin) 		3 HIS A 269
VAL A 229
LEU A 375
 None
 0.71A 4m2vA-2owmA:
undetectable		 4m2vA-2owmA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Helicobacter
pylori) 		PF13561
(adh_short_C2) 		3 HIS A  90
VAL A  78
LEU A 130
 None
 0.75A 4m2vA-2pd3A:
undetectable		 4m2vA-2pd3A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pey BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1 (PAPS
SYNTHETASE 1) (PAPSS
1) (SULFURYLASE
KINASE 1) (SK1) (SK
1)

(Homo sapiens) 		PF01583
(APS_kinase) 		3 HIS A  79
VAL A  55
LEU A 220
 None
 0.77A 4m2vA-2peyA:
undetectable		 4m2vA-2peyA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE

(Francisella
tularensis) 		no annotation 3 HIS B  20
VAL B  72
LEU B  26
 None
 0.75A 4m2vA-2qjtB:
undetectable		 4m2vA-2qjtB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qma DIAMINOBUTYRATE-PYRU
VATE TRANSAMINASE
AND
L-2,4-DIAMINOBUTYRAT
E DECARBOXYLASE

(Vibrio
parahaemolyticus) 		PF00282
(Pyridoxal_deC) 		3 HIS A 778
VAL A 676
LEU A 636
 None
 0.76A 4m2vA-2qmaA:
undetectable		 4m2vA-2qmaA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL

(Trichormus
variabilis) 		PF01261
(AP_endonuc_2) 		3 HIS A 218
VAL A 233
LEU A 195
 XLS  A 401 (-4.3A)
None
None
 0.68A 4m2vA-2qw5A:
undetectable		 4m2vA-2qw5A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3v MEVALONATE KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 HIS A  17
VAL A 310
LEU A 331
 None
 0.76A 4m2vA-2r3vA:
undetectable		 4m2vA-2r3vA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjq ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		3 HIS A 346
VAL A 319
LEU A 272
 None
 0.63A 4m2vA-2rjqA:
undetectable		 4m2vA-2rjqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rv8 DNA-BINDING RESPONSE
REGULATOR

(Mycobacterium
tuberculosis) 		PF00486
(Trans_reg_C) 		3 HIS A 201
VAL A 218
LEU A 181
 None
 0.57A 4m2vA-2rv8A:
undetectable		 4m2vA-2rv8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ubp PROTEIN (UREASE BETA
SUBUNIT)

(Sporosarcina
pasteurii) 		PF00699
(Urease_beta) 		3 HIS B  47
VAL B  85
LEU B  87
 None
 0.74A 4m2vA-2ubpB:
undetectable		 4m2vA-2ubpB:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7y CHAPERONE PROTEIN
DNAK

(Geobacillus
kaustophilus) 		PF00012
(HSP70) 		3 HIS A 331
VAL A 289
LEU A 164
 None
 0.74A 4m2vA-2v7yA:
undetectable		 4m2vA-2v7yA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vid SERINE PROTEASE SPLB

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		3 HIS A 123
VAL A  18
LEU A 131
 None
 0.75A 4m2vA-2vidA:
undetectable		 4m2vA-2vidA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 HIS A 302
VAL A 335
LEU A 293
 None
GOL  A1497 (-3.8A)
None
 0.70A 4m2vA-2vosA:
undetectable		 4m2vA-2vosA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		3 HIS A 428
VAL A 475
LEU A 454
 ZN  A1567 (-3.4A)
None
None
 0.64A 4m2vA-2w9mA:
undetectable		 4m2vA-2w9mA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 HIS A 283
VAL A 370
LEU A 290
 UNX  A1428 (-4.6A)
None
None
 0.76A 4m2vA-2wbiA:
undetectable		 4m2vA-2wbiA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans) 		PF03069
(FmdA_AmdA) 		3 HIS A  70
VAL A 272
LEU A 251
 ZN  A 411 ( 4.8A)
None
None
 0.62A 4m2vA-2wknA:
undetectable		 4m2vA-2wknA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzr POLYPROTEIN

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 HIS 2  64
VAL 2 123
LEU 2 179
 None
 0.63A 4m2vA-2wzr2:
undetectable		 4m2vA-2wzr2:
21.64