SIMILAR PATTERNS OF AMINO ACIDS FOR 4M2R_A_BZ1A302_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4a L-FUCULOSE
1-PHOSPHATE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		4 HIS P  94
GLU P 175
HIS P  97
LEU P 104
 ZN  P 304 (-3.3A)
None
None
None
 1.44A 4m2rA-1e4aP:
undetectable		 4m2rA-1e4aP:
20.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  64
GLU A 106
HIS A 119
LEU A 141
 None
ZN  A 901 ( 4.5A)
ZN  A 901 ( 3.1A)
None
 0.20A 4m2rA-1jd0A:
36.8		 4m2rA-1jd0A:
36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9u EARTHWORM
FIBRINOLYTIC ENZYME

(Eisenia fetida) 		PF00089
(Trypsin) 		4 HIS A 107
GLU A  92
HIS A  91
LEU A 235
 None
 1.46A 4m2rA-1m9uA:
undetectable		 4m2rA-1m9uA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE

(Thermotoga
maritima) 		PF04961
(FTCD_C) 		4 HIS A 121
GLU A 184
HIS A 146
LEU A 139
 None
 1.48A 4m2rA-1o5hA:
undetectable		 4m2rA-1o5hA:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 HIS A  64
GLU A 106
HIS A 119
LEU A 141
 None
ZN  A 601 ( 4.5A)
ZN  A 601 ( 3.2A)
None
 0.42A 4m2rA-1rj6A:
37.2		 4m2rA-1rj6A:
37.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		4 HIS A 333
GLU A 349
HIS A 234
LEU A 322
 None
 0.91A 4m2rA-1rkxA:
undetectable		 4m2rA-1rkxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tke THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF02824
(TGS)
PF07973
(tRNA_SAD) 		4 HIS A 194
GLU A 176
HIS A  81
LEU A  86
 None
 1.33A 4m2rA-1tkeA:
undetectable		 4m2rA-1tkeA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuo PUTATIVE
PHOSPHOMANNOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 HIS A 167
GLU A 162
HIS A 199
LEU A 202
 None
 1.25A 4m2rA-1tuoA:
undetectable		 4m2rA-1tuoA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		4 HIS A 335
GLU A 351
HIS A 236
LEU A 324
 None
 0.97A 4m2rA-1wvgA:
undetectable		 4m2rA-1wvgA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 HIS A  82
GLU A 425
HIS A 553
LEU A 551
 None
ZN  A1752 (-2.5A)
ZN  A1752 (-3.3A)
None
 1.36A 4m2rA-1z8lA:
undetectable		 4m2rA-1z8lA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs4 PROTEIN YCIF

(Escherichia
coli) 		PF05974
(DUF892) 		4 HIS A 111
GLU A 143
HIS A  47
LEU A  31
 None
 1.41A 4m2rA-2gs4A:
undetectable		 4m2rA-2gs4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvb SUPEROXIDE REDUCTASE

(Pyrococcus
horikoshii) 		PF01880
(Desulfoferrodox) 		4 HIS A  84
GLU A  23
HIS A 114
LEU A 116
 None
FE  A 201 (-3.7A)
FE  A 201 (-3.2A)
None
 1.42A 4m2rA-2hvbA:
undetectable		 4m2rA-2hvbA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m4k DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DELTA

(Bacillus
subtilis) 		PF05066
(HARE-HTH) 		4 HIS A  21
GLU A  26
HIS A  27
LEU A  37
 None
 1.28A 4m2rA-2m4kA:
undetectable		 4m2rA-2m4kA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9g CYTOCHROME P450 46A1

(Homo sapiens) 		PF00067
(p450) 		4 HIS A 310
GLU A 305
HIS A 304
LEU A 204
 HEM  A 505 ( 4.6A)
None
None
None
 1.01A 4m2rA-2q9gA:
undetectable		 4m2rA-2q9gA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00149
(Metallophos) 		4 HIS A 204
GLU A 155
HIS A 128
LEU A 123
 MN  A 401 ( 3.3A)
None
None
None
 1.42A 4m2rA-2qjcA:
undetectable		 4m2rA-2qjcA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 HIS A 886
GLU A 512
HIS A 544
LEU A 867
 None
 1.43A 4m2rA-2r6fA:
undetectable		 4m2rA-2r6fA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w57 FERRIC UPTAKE
REGULATION PROTEIN

(Vibrio cholerae) 		PF01475
(FUR) 		4 HIS A  86
GLU A 101
HIS A  33
LEU A  26
 None
ZN  A 202 ( 4.6A)
ZN  A 202 (-3.3A)
None
 1.47A 4m2rA-2w57A:
undetectable		 4m2rA-2w57A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wli POTASSIUM CHANNEL

(Magnetospirillum
magnetotacticum) 		PF01007
(IRK) 		4 HIS A 236
GLU A 184
HIS A 196
LEU A 159
 None
 1.39A 4m2rA-2wliA:
undetectable		 4m2rA-2wliA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvx CHELATASE, PUTATIVE

(Desulfovibrio
vulgaris) 		PF06180
(CbiK) 		4 HIS A 216
GLU A  94
HIS A  88
LEU A  28
 CO2  A1286 ( 3.3A)
GOL  A1277 (-4.5A)
SO4  A1273 (-4.4A)
None
 1.33A 4m2rA-2xvxA:
undetectable		 4m2rA-2xvxA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zds PUTATIVE DNA-BINDING
PROTEIN

(Streptomyces
coelicolor) 		PF01261
(AP_endonuc_2)
PF07582
(AP_endonuc_2_N) 		4 HIS A 177
GLU A  32
HIS A 233
LEU A 282
 None
 1.35A 4m2rA-2zdsA:
undetectable		 4m2rA-2zdsA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cny INOSITOL CATABOLISM
PROTEIN IOLE

(Lactobacillus
plantarum) 		PF01261
(AP_endonuc_2) 		4 HIS A 192
GLU A  48
HIS A 213
LEU A 260
 None
 1.07A 4m2rA-3cnyA:
undetectable		 4m2rA-3cnyA:
22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  65
GLU A 107
HIS A 120
LEU A 142
 None
ZN  A 301 ( 4.9A)
ZN  A 301 ( 3.2A)
None
 0.27A 4m2rA-3da2A:
42.5		 4m2rA-3da2A:
59.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  85
GLU A 125
HIS A 138
LEU A 159
 None
MG  A 901 ( 4.4A)
MG  A 901 (-3.2A)
None
 0.56A 4m2rA-3fe4A:
31.5		 4m2rA-3fe4A:
34.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Giardia
intestinalis) 		PF01116
(F_bP_aldolase) 		4 HIS A 109
GLU A 135
HIS A  84
LEU A  82
 None
None
ZN  A 326 (-3.4A)
None
 1.48A 4m2rA-3gayA:
undetectable		 4m2rA-3gayA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA

(Escherichia
coli) 		PF06144
(DNA_pol3_delta)
PF14840
(DNA_pol3_delt_C) 		4 HIS A 231
GLU A 239
HIS A 211
LEU A 178
 None
 1.43A 4m2rA-3glgA:
undetectable		 4m2rA-3glgA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 201
GLU A 607
HIS A 262
LEU A 154
 C2O  A1002 (-3.7A)
None
None
None
 1.39A 4m2rA-3gyrA:
undetectable		 4m2rA-3gyrA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwl UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 4 HIS A 384
GLU A 375
HIS A 436
LEU A 352
 None
 1.43A 4m2rA-3kwlA:
undetectable		 4m2rA-3kwlA:
19.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  64
GLU A 106
HIS A 119
LEU A 141
 None
ZN  A 263 ( 4.6A)
ZN  A 263 ( 3.1A)
None
 0.35A 4m2rA-3ml5A:
43.2		 4m2rA-3ml5A:
56.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 HIS A1096
GLU A1117
HIS A1132
LEU A1153
 None
 1.33A 4m2rA-3mpxA:
undetectable		 4m2rA-3mpxA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obz PHYTANOYL-COA
DIOXYGENASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05721
(PhyH) 		4 HIS A 156
GLU A 243
HIS A 241
LEU A 264
 FE2  A 482 ( 3.4A)
None
None
None
 1.41A 4m2rA-3obzA:
undetectable		 4m2rA-3obzA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq3 IFN-ALPHA/BETA
BINDING PROTEIN C12R

(Ectromelia
virus) 		PF00047
(ig)
PF13895
(Ig_2) 		4 HIS B 140
GLU B 136
HIS B 227
LEU B 262
 ZN  A 167 (-3.3A)
None
None
None
 1.42A 4m2rA-3oq3B:
undetectable		 4m2rA-3oq3B:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdk RIBULOKINASE

(Bacillus
halodurans) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 HIS A  55
GLU A 172
HIS A 120
LEU A  46
 None
 1.46A 4m2rA-3qdkA:
undetectable		 4m2rA-3qdkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 HIS A 479
GLU A 486
HIS A 487
LEU A 717
 ZN  A   3 ( 3.4A)
None
None
None
 1.23A 4m2rA-3ttfA:
undetectable		 4m2rA-3ttfA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		4 HIS A 903
GLU A 528
HIS A 560
LEU A 884
 None
 1.37A 4m2rA-3zqjA:
undetectable		 4m2rA-3zqjA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acz ENDO-ALPHA-MANNOSIDA
SE

(Bacteroides
thetaiotaomicron) 		PF16317
(Glyco_hydro_99) 		4 HIS B 331
GLU B 154
HIS B 152
LEU B 120
 None
 1.41A 4m2rA-4aczB:
undetectable		 4m2rA-4aczB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B3168
GLU B2904
HIS B2724
LEU B2720
 None
 1.38A 4m2rA-4bedB:
undetectable		 4m2rA-4bedB:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		4 HIS A 122
GLU A 461
HIS A 115
LEU A 515
 None
None
None
NFU  A1004 (-3.7A)
 1.08A 4m2rA-4c3oA:
undetectable		 4m2rA-4c3oA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6o CAD PROTEIN

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 HIS A1770
GLU A1694
HIS A1690
LEU A1474
 None
None
FMT  A2824 (-4.2A)
None
 1.25A 4m2rA-4c6oA:
undetectable		 4m2rA-4c6oA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4

(Homo sapiens) 		PF01663
(Phosphodiest) 		4 HIS A  48
GLU A  55
HIS A 352
LEU A  29
 None
 1.43A 4m2rA-4lr2A:
undetectable		 4m2rA-4lr2A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		4 HIS A1161
GLU A1207
HIS A1241
LEU A1104
 None
 1.29A 4m2rA-4n1aA:
undetectable		 4m2rA-4n1aA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		4 HIS A1161
GLU A1207
HIS A1241
LEU A1104
 None
 1.08A 4m2rA-4nh0A:
undetectable		 4m2rA-4nh0A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4reu FERRITIN

(Escherichia
coli) 		PF00210
(Ferritin) 		4 HIS A 128
GLU A  94
HIS A  46
LEU A 161
 None
FE  A 202 (-1.9A)
None
None
 1.40A 4m2rA-4reuA:
undetectable		 4m2rA-4reuA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzh LIC12234

(Leptospira
interrogans) 		PF13855
(LRR_8) 		4 HIS A  71
GLU A  27
HIS A  31
LEU A  38
 ZN  A 301 (-3.1A)
None
ZN  A 302 ( 3.2A)
None
 1.40A 4m2rA-4tzhA:
undetectable		 4m2rA-4tzhA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utf GLYCOSYL HYDROLASE
FAMILY 71

(Bacteroides
xylanisolvens) 		PF16317
(Glyco_hydro_99) 		4 HIS A 335
GLU A 156
HIS A 154
LEU A 121
 MAN  A 500 (-4.5A)
IFM  A 501 (-2.8A)
IFM  A 501 (-4.1A)
None
 1.42A 4m2rA-4utfA:
undetectable		 4m2rA-4utfA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		4 HIS A   3
GLU A   9
HIS A 477
LEU A 186
 None
 1.35A 4m2rA-4wj3A:
undetectable		 4m2rA-4wj3A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 HIS A 321
GLU A 362
HIS A 366
LEU A 273
 None
 1.25A 4m2rA-4xhjA:
undetectable		 4m2rA-4xhjA:
17.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 HIS A 134
GLU A 166
HIS A 179
LEU A 190
 None
2HP  A 402 ( 4.7A)
ZN  A 401 ( 3.1A)
None
 0.53A 4m2rA-4xixA:
25.9		 4m2rA-4xixA:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620) 		no annotation 4 HIS A 376
GLU A 400
HIS A 374
LEU A 427
 None
NAG  A1004 (-3.9A)
None
None
 1.47A 4m2rA-4xn3A:
undetectable		 4m2rA-4xn3A:
17.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		4 HIS A 140
GLU A 171
HIS A 184
LEU A 194
 None
ZN  A 401 ( 4.5A)
ZN  A 401 ( 3.1A)
None
 0.24A 4m2rA-4xz5A:
29.9		 4m2rA-4xz5A:
33.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  64
GLU A 106
HIS A 119
LEU A 141
 None
ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.1A)
None
 0.15A 4m2rA-5cjfA:
36.9		 4m2rA-5cjfA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		4 HIS X  63
GLU X 105
HIS X 118
LEU X 139
 None
ZN  X 301 ( 4.6A)
ZN  X 301 (-3.1A)
None
 0.31A 4m2rA-5eztX:
44.4		 4m2rA-5eztX:
80.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		4 HIS A  71
GLU A 102
HIS A 115
LEU A 125
 None
ZN  A 301 ( 4.6A)
ZN  A 301 (-3.1A)
None
 0.40A 4m2rA-5hpjA:
29.5		 4m2rA-5hpjA:
35.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrm HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 4 HIS A 317
GLU A 273
HIS A 286
LEU A 234
 MN  A 602 (-3.2A)
None
None
None
 1.27A 4m2rA-5hrmA:
undetectable		 4m2rA-5hrmA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		4 HIS A 517
GLU A 463
HIS A 465
LEU A 480
 None
 1.38A 4m2rA-5hzwA:
undetectable		 4m2rA-5hzwA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioj HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 4 HIS A 317
GLU A 273
HIS A 286
LEU A 234
 None
 1.38A 4m2rA-5iojA:
undetectable		 4m2rA-5iojA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipx ORF49 PROTEIN

(Human
gammaherpesvirus
8) 		PF04793
(Herpes_BBRF1) 		4 HIS A 232
GLU A  69
HIS A  19
LEU A  15
 None
 1.21A 4m2rA-5ipxA:
undetectable		 4m2rA-5ipxA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7k PROTEIN UNC-119
HOMOLOG A

(Homo sapiens) 		PF05351
(GMP_PDE_delta) 		4 HIS A 192
GLU A 163
HIS A 165
LEU A 140
 None
 1.44A 4m2rA-5l7kA:
undetectable		 4m2rA-5l7kA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens) 		no annotation 4 HIS A 288
GLU A 420
HIS A 345
LEU A 280
 None
 1.47A 4m2rA-5m3xA:
undetectable		 4m2rA-5m3xA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ud0 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Helicobacter
pylori) 		no annotation 4 HIS A 108
GLU A 134
HIS A  83
LEU A  81
 None
ZN  A 402 (-1.9A)
ZN  A 402 (-3.4A)
None
 1.37A 4m2rA-5ud0A:
undetectable		 4m2rA-5ud0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czm -

(-) 		no annotation 4 HIS A 126
GLU A 360
HIS A 258
LEU A 371
 None
 1.24A 4m2rA-6czmA:
undetectable		 4m2rA-6czmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 4 HIS A  92
GLU A 123
HIS A 136
LEU A 146
 None
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.2A)
None
 0.28A 4m2rA-6ekiA:
30.0		 4m2rA-6ekiA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 4 HIS A  64
GLU A 106
HIS A 119
LEU A 141
 None
V14  A 302 (-4.2A)
ZN  A 301 ( 3.1A)
None
 0.38A 4m2rA-6fe1A:
34.0		 4m2rA-6fe1A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffj -

(-) 		no annotation 4 HIS A 454
GLU A  99
HIS A  35
LEU A  45
 None
 1.33A 4m2rA-6ffjA:
undetectable		 4m2rA-6ffjA:
undetectable