SIMILAR PATTERNS OF AMINO ACIDS FOR 4M11_C_MXMC606

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 ILE A 345
LEU A 352
LEU A 359
TRP A 387
ALA A 527
LEU A 534
 None
SCL  A 700 ( 4.8A)
None
None
SCL  A 700 (-2.9A)
OAS  A 530 ( 3.3A)
 0.64A 4m11C-1ebvA:
33.5		 4m11C-1ebvA:
64.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 MET A 113
ILE A 345
VAL A 349
LEU A 359
TRP A 387
ALA A 527
LEU A 534
 None
None
SCL  A 700 ( 4.6A)
None
None
SCL  A 700 (-2.9A)
OAS  A 530 ( 3.3A)
 0.48A 4m11C-1ebvA:
33.5		 4m11C-1ebvA:
64.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 MET A 113
VAL A 116
ILE A 345
VAL A 349
LEU A 359
TRP A 387
LEU A 534
 None
None
None
SCL  A 700 ( 4.6A)
None
None
OAS  A 530 ( 3.3A)
 0.62A 4m11C-1ebvA:
33.5		 4m11C-1ebvA:
64.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggp PROTEIN (LECTIN 1 A
CHAIN)

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		5 VAL A 239
ILE A 227
VAL A 229
LEU A 219
VAL A 205
 None
 1.39A 4m11C-1ggpA:
0.0		 4m11C-1ggpA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		5 MET A 238
ILE A 214
VAL A   8
LEU A   6
ALA A 230
 None
PO4  A1002 (-4.4A)
None
None
None
 1.31A 4m11C-1ixpA:
undetectable		 4m11C-1ixpA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kru GALACTOSIDE
O-ACETYLTRANSFERASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12464
(Mac)
PF14602
(Hexapep_2) 		5 VAL A 138
ILE A 146
VAL A 164
VAL A 181
ALA A 174
 None
 1.27A 4m11C-1kruA:
undetectable		 4m11C-1kruA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrk YGFZ PROTEIN

(Escherichia
coli) 		PF01571
(GCV_T) 		5 ILE A 194
LEU A 258
LEU A 190
ALA A 261
LEU A 280
 None
 1.15A 4m11C-1nrkA:
0.0		 4m11C-1nrkA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzg PROTECTION OF
TELOMERES PROTEIN 1

(Schizosaccharomyces
pombe) 		PF02765
(POT1) 		5 VAL A  69
ILE A 110
LEU A 107
SER A  33
LEU A 112
 None
 1.09A 4m11C-1qzgA:
0.0		 4m11C-1qzgA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 VAL A 297
ILE A 281
LEU A 329
LEU A 322
ALA A 287
 None
 1.09A 4m11C-1rzmA:
0.0		 4m11C-1rzmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ILE A 758
VAL A 639
LEU A 753
VAL A 628
ALA A 739
 None
 1.03A 4m11C-1sb3A:
0.0		 4m11C-1sb3A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ILE A 695
VAL A 699
LEU A 703
LEU A 696
LEU A 684
 None
 1.08A 4m11C-1sojA:
0.0		 4m11C-1sojA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Shewanella
oneidensis) 		PF02542
(YgbB) 		5 ILE A 129
VAL A 131
LEU A 118
VAL A 150
ALA A 152
 None
 1.20A 4m11C-1t0aA:
undetectable		 4m11C-1t0aA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6n PROBABLE
ATP-DEPENDENT RNA
HELICASE

(Homo sapiens) 		PF00270
(DEAD) 		5 MET A 140
VAL A 143
VAL A 100
LEU A 104
VAL A 170
 None
 1.33A 4m11C-1t6nA:
undetectable		 4m11C-1t6nA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uh9 HIZOPUSPEPSIN I

(Rhizopus
microsporus) 		PF00026
(Asp) 		5 VAL A 271
ILE A 299
LEU A 224
VAL A 209
ALA A 202
 None
 1.02A 4m11C-1uh9A:
undetectable		 4m11C-1uh9A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqs HSPBP1 PROTEIN

(Homo sapiens) 		PF08609
(Fes1) 		5 VAL A 234
LEU A 154
VAL A 204
ALA A 208
LEU A 215
 None
 1.01A 4m11C-1xqsA:
undetectable		 4m11C-1xqsA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		6 VAL A 122
ILE A 113
LEU A 113
VAL A  35
ALA A  54
SER A  58
 None
 1.02A 4m11C-1ygpA:
undetectable		 4m11C-1ygpA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5y APOPTOSIS REGULATOR
CED-9

(Caenorhabditis
elegans) 		PF00452
(Bcl-2)
PF02180
(BH4) 		5 MET A 185
ILE A 144
LEU A 198
VAL A 156
LEU A 148
 None
 1.36A 4m11C-2a5yA:
undetectable		 4m11C-2a5yA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e44 INSULIN-LIKE GROWTH
FACTOR 2 MRNA
BINDING PROTEIN 3

(Homo sapiens) 		PF00076
(RRM_1) 		5 ILE A  85
VAL A 124
ALA A 132
LEU A 136
LEU A 139
 None
 0.94A 4m11C-2e44A:
undetectable		 4m11C-2e44A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jan TYROSYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00579
(tRNA-synt_1b) 		5 VAL A  35
VAL A 205
ALA A 218
SER A  18
LEU A 219
 None
 1.39A 4m11C-2janA:
undetectable		 4m11C-2janA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lg1 A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		PF00169
(PH) 		5 ILE A  97
VAL A  89
ALA A  91
LEU A  93
LEU A  94
 None
 0.92A 4m11C-2lg1A:
undetectable		 4m11C-2lg1A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila) 		PF13378
(MR_MLE_C) 		5 ILE A 106
LEU A  69
LEU A 107
VAL A  35
LEU A  81
 None
 1.20A 4m11C-2pgeA:
undetectable		 4m11C-2pgeA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10

(Homo sapiens) 		PF00270
(DEAD) 		5 ILE A 240
VAL A 239
LEU A 202
LEU A 243
LEU A 221
 None
 1.27A 4m11C-2pl3A:
undetectable		 4m11C-2pl3A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ILE A 166
VAL A 155
LEU A 159
VAL A 282
ALA A 260
 None
 1.25A 4m11C-2qygA:
undetectable		 4m11C-2qygA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjb UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		PF07063
(DUF1338) 		5 ILE A 211
VAL A 215
LEU A 204
ALA A 146
LEU A 131
 None
 1.29A 4m11C-2rjbA:
undetectable		 4m11C-2rjbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjn RESPONSE REGULATOR
RECEIVER:METAL-DEPEN
DENT
PHOSPHOHYDROLASE, HD
SUBDOMAIN

(Neptuniibacter
caesariensis) 		PF00072
(Response_reg) 		5 ILE A  34
VAL A  10
LEU A  54
LEU A  12
VAL A 119
 None
 1.12A 4m11C-2rjnA:
undetectable		 4m11C-2rjnA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A1023
VAL A1052
LEU A1056
LEU A1049
LEU A1000
 None
 1.33A 4m11C-2vdcA:
undetectable		 4m11C-2vdcA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 VAL A1052
LEU A1056
LEU A1049
LEU A1022
LEU A1000
 None
 0.87A 4m11C-2vdcA:
undetectable		 4m11C-2vdcA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25

(Homo sapiens) 		PF03801
(Ndc80_HEC)
PF08234
(Spindle_Spc25) 		5 MET A 169
LEU A 164
ALA A 183
LEU A 185
LEU A 188
 None
 1.19A 4m11C-2ve7A:
undetectable		 4m11C-2ve7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ILE B 473
VAL B 479
VAL B 497
ALA B 500
LEU B 547
 None
 1.14A 4m11C-2w55B:
undetectable		 4m11C-2w55B:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		5 ILE A 113
VAL A 150
LEU A 115
LEU A 332
LEU A 335
 None
 0.96A 4m11C-2x24A:
undetectable		 4m11C-2x24A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2w ARABINOFURANOSIDASE

(Bifidobacterium
longum) 		PF06964
(Alpha-L-AF_C) 		5 VAL A  96
VAL A 108
LEU A 410
ALA A 159
SER A 156
 None
 1.07A 4m11C-2y2wA:
undetectable		 4m11C-2y2wA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		5 ILE A 464
VAL A 450
VAL A 416
ALA A 420
LEU A 467
 None
 1.40A 4m11C-2z6gA:
undetectable		 4m11C-2z6gA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		5 VAL A 493
ILE A 443
LEU A 408
ALA A 463
LEU A 470
 None
 1.12A 4m11C-2z6gA:
undetectable		 4m11C-2z6gA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		5 VAL A 290
ILE A 363
VAL A 362
LEU A 366
VAL A   9
 None
 0.76A 4m11C-3bn1A:
undetectable		 4m11C-3bn1A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c24 PUTATIVE
OXIDOREDUCTASE

(Jannaschia sp.
CCS1) 		PF03807
(F420_oxidored)
PF16896
(PGDH_C) 		5 VAL A 202
ILE A 228
LEU A 231
ALA A 208
LEU A 224
 None
 1.25A 4m11C-3c24A:
undetectable		 4m11C-3c24A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d01 UNCHARACTERIZED
PROTEIN

(Agrobacterium
fabrum) 		PF14588
(YjgF_endoribonc) 		5 VAL A 132
ILE A  84
VAL A  88
LEU A  92
LEU A  85
 None
 1.09A 4m11C-3d01A:
undetectable		 4m11C-3d01A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez1 AMINOTRANSFERASE
MOCR FAMILY

(Deinococcus
geothermalis) 		PF12897
(Aminotran_MocR) 		5 MET A 404
VAL A 407
ILE A 347
LEU A 390
ALA A 336
 None
 1.26A 4m11C-3ez1A:
undetectable		 4m11C-3ez1A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A 312
LEU A 315
VAL A 341
ALA A 378
SER A 382
 None
 1.38A 4m11C-3g25A:
undetectable		 4m11C-3g25A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 315
VAL A 341
ALA A 378
SER A 382
LEU A 383
 None
 1.38A 4m11C-3g25A:
undetectable		 4m11C-3g25A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Burkholderia
pseudomallei) 		PF03740
(PdxJ) 		5 MET A 245
ILE A 221
VAL A  15
LEU A  13
ALA A 237
 None
 1.34A 4m11C-3gk0A:
undetectable		 4m11C-3gk0A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5q PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Staphylococcus
aureus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 MET A  50
ILE A  21
LEU A  58
ALA A  38
LEU A  41
 None
 1.33A 4m11C-3h5qA:
undetectable		 4m11C-3h5qA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixl ARYLMALONATE
DECARBOXYLASE

(Bordetella
bronchiseptica) 		no annotation 5 VAL A 209
LEU A 236
LEU A 185
ALA A 107
LEU A 109
 None
 1.33A 4m11C-3ixlA:
undetectable		 4m11C-3ixlA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyj MAJOR CAPSID PROTEIN
L1

(Deltapapillomavirus
4) 		no annotation 5 ILE F 373
LEU F 461
VAL F 476
ALA F 467
LEU F 466
 None
 1.19A 4m11C-3iyjF:
undetectable		 4m11C-3iyjF:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 ILE A 195
LEU A 521
VAL A 202
ALA A 200
LEU A 171
 None
 1.26A 4m11C-3js8A:
undetectable		 4m11C-3js8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpx DNA GYRASE, A
SUBUNIT

(Colwellia
psychrerythraea) 		PF00521
(DNA_topoisoIV) 		5 ILE A 274
LEU A 286
LEU A 292
VAL A 316
LEU A 273
 None
 1.20A 4m11C-3lpxA:
1.4		 4m11C-3lpxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 MET A  76
VAL A  75
LEU A  18
ALA A  57
LEU A  50
 None
 1.29A 4m11C-3m9uA:
undetectable		 4m11C-3m9uA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacteroides
thetaiotaomicron) 		PF08543
(Phos_pyr_kin) 		5 MET A 132
VAL A  12
LEU A  40
LEU A  85
TRP A  70
 None
 1.35A 4m11C-3mbhA:
1.7		 4m11C-3mbhA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqw CG11900

(Drosophila
melanogaster) 		PF13328
(HD_4) 		5 ILE A  50
VAL A  55
LEU A  44
VAL A  90
ALA A 116
 None
 1.27A 4m11C-3nqwA:
undetectable		 4m11C-3nqwA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr1 HD DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF13328
(HD_4) 		5 ILE A  49
VAL A  54
LEU A  43
VAL A  89
ALA A 115
 None
 1.27A 4m11C-3nr1A:
undetectable		 4m11C-3nr1A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onk EPSIN-3

(Saccharomyces
cerevisiae) 		PF01417
(ENTH) 		5 ILE A  68
VAL A  36
ALA A  90
LEU A  94
LEU A  97
 None
 0.95A 4m11C-3onkA:
undetectable		 4m11C-3onkA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqh PUTATIVE
UNCHARACTERIZED
PROTEIN YVMC

(Bacillus
licheniformis) 		PF16715
(CDPS) 		5 VAL A 221
ILE A 182
VAL A 181
LEU A 185
ALA A 146
 None
 0.99A 4m11C-3oqhA:
undetectable		 4m11C-3oqhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmm PUTATIVE CYTOPLASMIC
PROTEIN

(Klebsiella
pneumoniae) 		PF07470
(Glyco_hydro_88) 		5 MET A  86
ILE A  28
VAL A  31
ALA A 365
LEU A 371
 FMT  A 387 ( 4.1A)
None
None
None
None
 1.18A 4m11C-3pmmA:
undetectable		 4m11C-3pmmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 ILE A 145
VAL A  99
ALA A 134
LEU A 136
LEU A 139
 None
 1.15A 4m11C-3pxxA:
undetectable		 4m11C-3pxxA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7b NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF17290
(Arena_ncap_C) 		5 ILE A 450
VAL A 449
LEU A 373
LEU A 453
VAL A 553
 None
 1.14A 4m11C-3q7bA:
undetectable		 4m11C-3q7bA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvu SULFOTRANSFERASE 1A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 VAL A 220
ILE A 207
VAL A 211
LEU A 208
LEU A  58
 None
 1.39A 4m11C-3qvuA:
undetectable		 4m11C-3qvuA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A  40
ALA A  75
SER A  71
LEU A  74
LEU A  10
 None
 1.33A 4m11C-3ugvA:
undetectable		 4m11C-3ugvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uz0 STAGE II SPORULATION
PROTEIN Q
STAGE III
SPORULATION PROTEIN
AH

(Bacillus
subtilis) 		PF01551
(Peptidase_M23)
PF12685
(SpoIIIAH) 		5 ILE A 181
VAL A 210
LEU B 118
ALA A 201
LEU A 199
 None
 1.32A 4m11C-3uz0A:
undetectable		 4m11C-3uz0A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		5 VAL A  83
ILE A  98
VAL A 127
LEU A 166
LEU A 118
 None
 1.17A 4m11C-3vywA:
undetectable		 4m11C-3vywA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 VAL A  21
ILE A 111
LEU A  79
VAL A  25
ALA A 117
 None
 1.11A 4m11C-4a3rA:
undetectable		 4m11C-4a3rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Neurospora
crassa) 		no annotation 5 ILE A 456
LEU A 409
TRP A 493
VAL A 506
ALA A 393
 None
 1.39A 4m11C-4bwkA:
1.6		 4m11C-4bwkA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 ILE A 438
VAL A 442
LEU A 439
SER A 343
LEU A 342
 None
 0.93A 4m11C-4f7zA:
undetectable		 4m11C-4f7zA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		5 VAL A 368
ILE A 281
LEU A 273
VAL A 297
ALA A 294
 None
 1.40A 4m11C-4k05A:
undetectable		 4m11C-4k05A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqx TENA/THI-4
DOMAIN-CONTAINING
PROTEIN

(Sulfolobus
solfataricus) 		PF03070
(TENA_THI-4)
PF16293
(zf-C2H2_9) 		5 TRP A  68
VAL A 268
ALA A 196
SER A 200
LEU A 201
 None
None
None
None
UNL  A 402 ( 4.9A)
 1.33A 4m11C-4lqxA:
undetectable		 4m11C-4lqxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 ILE A 274
VAL A 298
LEU A 324
LEU A 295
LEU A 288
 None
 1.33A 4m11C-4lxrA:
undetectable		 4m11C-4lxrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxx CINDOXIN

(Citrobacter
braakii) 		PF00258
(Flavodoxin_1) 		5 MET A   1
VAL A  29
LEU A  51
ALA A 141
LEU A 145
 None
 1.17A 4m11C-4oxxA:
undetectable		 4m11C-4oxxA:
14.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		8 MET A 114
ILE A 346
VAL A 350
LEU A 360
TRP A 388
VAL A 524
ALA A 528
LEU A 535
 None
None
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.4A)
EDO  A 616 ( 4.4A)
 0.36A 4m11C-4ph9A:
63.5		 4m11C-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 MET A 114
VAL A 117
ILE A 346
VAL A 350
LEU A 360
TRP A 388
LEU A 535
 None
BOG  A 604 (-3.9A)
None
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
None
EDO  A 616 ( 4.4A)
 0.57A 4m11C-4ph9A:
63.5		 4m11C-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 MET A 114
VAL A 117
VAL A 350
LEU A 360
SER A 531
 None
BOG  A 604 (-3.9A)
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 ( 3.3A)
 0.84A 4m11C-4ph9A:
63.5		 4m11C-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 MET A 114
VAL A 350
LEU A 360
VAL A 524
ALA A 528
SER A 531
 None
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
 0.69A 4m11C-4ph9A:
63.5		 4m11C-4ph9A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		5 ILE A 370
LEU A 368
VAL A 563
ALA A 573
LEU A 572
 None
 1.39A 4m11C-4qeoA:
undetectable		 4m11C-4qeoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 VAL B 991
VAL B 705
ALA B 937
SER B 938
LEU B 939
 None
 1.18A 4m11C-4qiwB:
undetectable		 4m11C-4qiwB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 VAL A 147
ILE A 107
SER A 118
LEU A 121
LEU A 113
 None
 1.40A 4m11C-4rewA:
undetectable		 4m11C-4rewA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmk PROTEIN (THYMIDYLATE
KINASE)

(Escherichia
coli) 		PF02223
(Thymidylate_kin) 		5 ILE A 200
VAL A  23
LEU A  27
TRP A  95
LEU A 137
 None
 1.25A 4m11C-4tmkA:
undetectable		 4m11C-4tmkA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase) 		5 VAL A 266
LEU A 278
LEU A 268
VAL A 302
LEU A 431
 None
 1.22A 4m11C-4u3tA:
undetectable		 4m11C-4u3tA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ILE A 470
LEU A 476
ALA A 494
LEU A 497
LEU A 445
 None
 1.38A 4m11C-4uadA:
undetectable		 4m11C-4uadA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yly PEPTIDYL-TRNA
HYDROLASE

(Staphylococcus
aureus) 		PF01195
(Pept_tRNA_hydro) 		5 VAL A 189
ILE A 162
VAL A  25
LEU A  89
ALA A 168
 None
 1.32A 4m11C-4ylyA:
undetectable		 4m11C-4ylyA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 165
VAL A 247
ALA A 106
SER A 110
LEU A 112
 None
 1.03A 4m11C-5bp1A:
undetectable		 4m11C-5bp1A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs1 CRRBCX-IIA

(Chlamydomonas
reinhardtii) 		PF02341
(RcbX) 		5 MET A 105
VAL A 108
VAL A  66
LEU A 119
ALA A  84
 LEU  A 119 ( 3.8A)
VAL  A 108 ( 0.6A)
VAL  A  66 ( 0.6A)
LEU  A 119 ( 0.6A)
ALA  A  84 ( 0.0A)
 1.19A 4m11C-5bs1A:
undetectable		 4m11C-5bs1A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e44 FNR REGULATOR

(Aliivibrio
fischeri) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 ILE A 143
LEU A 146
ALA A  70
LEU A  68
LEU A 129
 None
None
SF4  A 301 ( 3.8A)
None
None
 1.19A 4m11C-5e44A:
undetectable		 4m11C-5e44A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy2 FLAGELLIN

(Bacillus
subtilis) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C) 		5 VAL C 172
ILE C 196
VAL C 199
LEU C  80
LEU C  87
 None
 1.36A 4m11C-5gy2C:
undetectable		 4m11C-5gy2C:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i33 ADENYLOSUCCINATE
SYNTHETASE

(Cryptococcus
neoformans) 		PF00709
(Adenylsucc_synt) 		5 ILE A 250
VAL A 253
LEU A 257
VAL A 223
LEU A  12
 None
 0.97A 4m11C-5i33A:
undetectable		 4m11C-5i33A:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 MET A 113
ILE A 345
VAL A 349
LEU A 352
LEU A 359
TRP A 387
VAL A 523
ALA A 527
SER A 530
LEU A 534
 None
None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
None
 0.42A 4m11C-5ikrA:
37.0		 4m11C-5ikrA:
88.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 MET A 113
VAL A 116
ILE A 345
VAL A 349
LEU A 359
TRP A 387
VAL A 523
ALA A 527
SER A 530
LEU A 534
 None
None
None
ID8  A 601 (-3.9A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
None
 0.49A 4m11C-5ikrA:
37.0		 4m11C-5ikrA:
88.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		5 ILE A 255
LEU A 253
ALA A 434
SER A 438
LEU A 439
 None
 1.24A 4m11C-5iuyA:
undetectable		 4m11C-5iuyA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy6 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT

(Homo sapiens) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		5 ILE V 439
LEU V 440
VAL V 458
ALA V 460
LEU V 437
 None
 1.28A 4m11C-5iy6V:
undetectable		 4m11C-5iy6V:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvk PROTEIN KP700603

(Klebsiella
pneumoniae) 		PF02464
(CinA) 		5 ILE A 108
LEU A 162
LEU A  41
TRP A 169
ALA A 105
 None
 1.33A 4m11C-5kvkA:
undetectable		 4m11C-5kvkA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 VAL B 145
ILE B  58
VAL B 114
VAL B  90
ALA B 101
 None
 1.23A 4m11C-5ldrB:
undetectable		 4m11C-5ldrB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loi RAD26

(Thermothelomyces
thermophila) 		PF12331
(DUF3636) 		5 ILE A 813
LEU A 800
VAL A 679
ALA A 683
LEU A 687
 None
 1.39A 4m11C-5loiA:
0.3		 4m11C-5loiA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1m MATRIX PROTEIN 1

(Influenza C
virus) 		PF03026
(CM1) 		5 ILE A  60
VAL A 125
VAL A 107
ALA A 146
LEU A 148
 None
 1.18A 4m11C-5m1mA:
undetectable		 4m11C-5m1mA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 5 ILE A  82
LEU A  79
VAL A 181
ALA A 179
SER A 178
 None
None
None
None
FRU  A 707 (-2.7A)
 0.96A 4m11C-5n6vA:
undetectable		 4m11C-5n6vA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD) 		5 VAL J 463
VAL J 452
LEU J 404
LEU J 454
LEU J 356
 None
 1.05A 4m11C-5nilJ:
undetectable		 4m11C-5nilJ:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 5 VAL C  72
LEU C  74
LEU C 115
VAL C  62
LEU C  43
 None
 1.02A 4m11C-5o4gC:
undetectable		 4m11C-5o4gC:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sup ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 MET A 157
VAL A 160
VAL A 117
LEU A 121
VAL A 189
 None
 1.41A 4m11C-5supA:
undetectable		 4m11C-5supA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suq ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 MET A 157
VAL A 160
VAL A 117
LEU A 121
VAL A 189
 None
 1.41A 4m11C-5suqA:
undetectable		 4m11C-5suqA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svd NUCLEOLAR PROTEIN 9

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 ILE A 114
LEU A 115
ALA A 155
SER A 153
LEU A 149
 ILE  A 114 ( 0.7A)
LEU  A 115 ( 0.5A)
ALA  A 155 ( 0.0A)
SER  A 153 ( 0.0A)
LEU  A 149 ( 0.6A)
 1.29A 4m11C-5svdA:
undetectable		 4m11C-5svdA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufl PROTEIN CIP2A

(Homo sapiens) 		no annotation 5 ILE A 238
LEU A 237
ALA A 208
SER A 210
LEU A 257
 None
 1.36A 4m11C-5uflA:
2.0		 4m11C-5uflA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4

(Mus musculus) 		no annotation 5 VAL A  96
LEU A  83
LEU A  90
ALA A 103
LEU A 100
 None
 1.30A 4m11C-5z96A:
2.2		 4m11C-5z96A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zct -

(-) 		no annotation 5 VAL A 197
ILE A 270
VAL A 261
ALA A 245
LEU A 267
 None
 1.40A 4m11C-5zctA:
undetectable		 4m11C-5zctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 5 MET A 198
VAL A 201
LEU A  79
LEU A 104
LEU A 116
 None
 1.27A 4m11C-6ap6A:
undetectable		 4m11C-6ap6A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 5 ILE A  90
VAL A  23
LEU A  87
ALA A  68
LEU A  39
 None
 1.05A 4m11C-6fikA:
undetectable		 4m11C-6fikA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a76 FLAP ENDONUCLEASE-1
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 LEU A 177
ARG A 186
MET A 194
 None
 0.97A 4m11C-1a76A:
0.0		 4m11C-1a76A:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 LEU A 117
ARG A 120
MET A 522
 None
SCL  A 700 (-3.9A)
None
 0.68A 4m11C-1ebvA:
33.5		 4m11C-1ebvA:
64.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey2 HOMOGENTISATE
1,2-DIOXYGENASE

(Homo sapiens) 		PF04209
(HgmA) 		3 LEU A  39
ARG A  63
MET A 186
 None
 0.93A 4m11C-1ey2A:
undetectable		 4m11C-1ey2A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 LEU A 250
ARG A 249
MET A 445
 None
 0.90A 4m11C-1ezvA:
0.0		 4m11C-1ezvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fb5 ORNITHINE
TRANSCARBAMOYLASE

(Ovis aries) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 LEU A 304
ARG A 330
MET A 335
 None
 0.98A 4m11C-1fb5A:
0.0		 4m11C-1fb5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE

(Escherichia
virus Lambda) 		PF00149
(Metallophos) 		3 LEU A  44
ARG A  70
MET A   1
 None
 0.91A 4m11C-1g5bA:
undetectable		 4m11C-1g5bA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE

(Thermus
thermophilus) 		PF00764
(Arginosuc_synth) 		3 LEU A  94
ARG A  92
MET A 174
 None
ATP  A 510 ( 4.1A)
None
 0.93A 4m11C-1kh2A:
0.0		 4m11C-1kh2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzr ERYTHRONOLIDE
SYNTHASE

(Saccharopolyspora
erythraea) 		PF08990
(Docking) 		3 LEU A  93
ARG A  95
MET A  82
 None
 0.87A 4m11C-1pzrA:
undetectable		 4m11C-1pzrA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 3 LEU A 258
ARG A 269
MET A 144
 None
 0.52A 4m11C-1qi9A:
0.2		 4m11C-1qi9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1

(Canis lupus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 LEU A 169
ARG A 171
MET A 307
 None
 0.92A 4m11C-1rp1A:
0.0		 4m11C-1rp1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		3 LEU A 176
ARG A 214
MET A 194
 None
 0.80A 4m11C-1su7A:
undetectable		 4m11C-1su7A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 LEU A 416
ARG A  37
MET A  34
 None
UMA  A 963 (-3.0A)
None
 0.94A 4m11C-1uagA:
undetectable		 4m11C-1uagA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		3 LEU B  35
ARG B  36
MET A 116
 None
 0.93A 4m11C-1wytB:
undetectable		 4m11C-1wytB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		3 LEU A 507
ARG A 505
MET A 443
 None
 0.94A 4m11C-1xl8A:
undetectable		 4m11C-1xl8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4v RNA EDITING COMPLEX
PROTEIN MP57

(Trypanosoma
brucei) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		3 LEU A  70
ARG A 127
MET A 240
 None
 0.91A 4m11C-2b4vA:
undetectable		 4m11C-2b4vA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc5 GLUTATHIONE
S-TRANSFERASE, MU 7

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 LEU A  28
ARG A  25
MET A 215
 None
 0.99A 4m11C-2dc5A:
undetectable		 4m11C-2dc5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es7 PUTATIVE
THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXIN

(Salmonella
enterica) 		PF07449
(HyaE) 		3 LEU A  15
ARG A  17
MET A  57
 None
 0.99A 4m11C-2es7A:
undetectable		 4m11C-2es7A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		3 LEU A  83
ARG A  37
MET A  46
 None
 0.92A 4m11C-2g04A:
undetectable		 4m11C-2g04A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		3 LEU A 111
ARG A 108
MET A 453
 None
HEM  A 900 (-2.4A)
None
 0.90A 4m11C-2hi4A:
undetectable		 4m11C-2hi4A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2l YOPX PROTEIN

(Bacillus
subtilis) 		PF09643
(YopX) 		3 LEU A  41
ARG A  35
MET A  13
 None
 0.99A 4m11C-2i2lA:
undetectable		 4m11C-2i2lA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 LEU A 766
ARG A 767
MET A 746
 None
 0.97A 4m11C-2jgdA:
undetectable		 4m11C-2jgdA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lki PUTATIVE
UNCHARACTERIZED
PROTEIN

(Nitrosomonas
europaea) 		PF00550
(PP-binding) 		3 LEU A  17
ARG A   8
MET A   1
 None
 0.96A 4m11C-2lkiA:
undetectable		 4m11C-2lkiA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 LEU A 173
ARG A 331
MET A 281
 LEU  A 173 ( 0.6A)
ARG  A 331 ( 0.6A)
PHE  A 279 ( 3.6A)
 0.95A 4m11C-2nvvA:
undetectable		 4m11C-2nvvA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 LEU A 187
ARG A 189
MET A 325
 None
 0.99A 4m11C-2pplA:
undetectable		 4m11C-2pplA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt5 GLUTAMATE
RECEPTOR-INTERACTING
PROTEIN 1

(Rattus
norvegicus) 		PF00595
(PDZ) 		3 LEU A 203
ARG A 202
MET A 147
 None
 0.87A 4m11C-2qt5A:
undetectable		 4m11C-2qt5A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		3 LEU A 427
ARG A 535
MET A 530
 None
 0.97A 4m11C-2qvwA:
3.1		 4m11C-2qvwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		3 LEU A 336
ARG A 337
MET A 360
 None
 0.95A 4m11C-2wu0A:
undetectable		 4m11C-2wu0A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al5 JMJC
DOMAIN-CONTAINING
PROTEIN C2ORF60

(Homo sapiens) 		PF13621
(Cupin_8) 		3 LEU A 107
ARG A 149
MET A 164
 None
 0.88A 4m11C-3al5A:
undetectable		 4m11C-3al5A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4f (+)-DELTA-CADINENE
SYNTHASE ISOZYME XC1

(Gossypium
arboreum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 LEU A 547
ARG A 293
MET A 421
 None
 1.00A 4m11C-3g4fA:
undetectable		 4m11C-3g4fA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 LEU A 253
ARG A 285
MET A 406
 None
 0.89A 4m11C-3gm8A:
undetectable		 4m11C-3gm8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		3 LEU A 362
ARG A 359
MET A 352
 None
 0.84A 4m11C-3hmjA:
undetectable		 4m11C-3hmjA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		3 LEU A 242
ARG A 258
MET A 433
 None
 0.71A 4m11C-3l7gA:
undetectable		 4m11C-3l7gA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS

(Streptomyces
sp. CK4412) 		PF00975
(Thioesterase) 		3 LEU A  32
ARG A  33
MET A  68
 None
 0.98A 4m11C-3lcrA:
undetectable		 4m11C-3lcrA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6s CHROMOBOX PROTEIN
HOMOLOG 1

(Homo sapiens) 		PF01393
(Chromo_shadow) 		3 LEU A 168
ARG A 167
MET A 136
 None
 0.80A 4m11C-3q6sA:
undetectable		 4m11C-3q6sA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE

(Alteromonas
macleodii) 		PF00557
(Peptidase_M24) 		3 LEU A 242
ARG A 258
MET A 436
 None
 0.81A 4m11C-3rvaA:
undetectable		 4m11C-3rvaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqz PUTATIVE
HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Streptococcus
mutans) 		PF00195
(Chal_sti_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 LEU A 333
ARG A 332
MET A 160
 None
GOL  A 392 (-4.0A)
None
 0.92A 4m11C-3sqzA:
undetectable		 4m11C-3sqzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		3 LEU A1638
ARG A1635
MET A1623
 None
 0.82A 4m11C-3topA:
undetectable		 4m11C-3topA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsr RIBONUCLEASE
INHIBITOR
RIBONUCLEASE
PANCREATIC

(Mus musculus) 		PF00074
(RnaseA)
PF13516
(LRR_6) 		3 LEU E 452
ARG E 453
MET A  36
 None
 0.77A 4m11C-3tsrE:
undetectable		 4m11C-3tsrE:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1v 2-METHYLISOBORNEOL
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 3 LEU A 274
ARG A 273
MET A 330
 GST  A 511 (-4.6A)
None
None
 0.96A 4m11C-3v1vA:
undetectable		 4m11C-3v1vA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5p PROTEIN MXIA

(Shigella
flexneri) 		PF00771
(FHIPEP) 		3 LEU A 537
ARG A 536
MET A 617
 None
 0.70A 4m11C-4a5pA:
undetectable		 4m11C-4a5pA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 LEU A 785
ARG A 822
MET A 234
 None
 0.75A 4m11C-4bedA:
1.0		 4m11C-4bedA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0e NOT1

(Chaetomium
thermophilum) 		PF04054
(Not1) 		3 LEU A2145
ARG A2143
MET A2098
 None
 0.93A 4m11C-4c0eA:
undetectable		 4m11C-4c0eA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 LEU A 391
ARG A 425
MET A 558
 None
EDO  A1986 (-3.7A)
None
 0.99A 4m11C-4cu8A:
undetectable		 4m11C-4cu8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		3 LEU A 327
ARG A 310
MET A 341
 None
 0.95A 4m11C-4cvcA:
undetectable		 4m11C-4cvcA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dni FUSION PROTEIN OF
RNA-EDITING COMPLEX
PROTEINS MP42 AND
MP18

(Trypanosoma
brucei) 		PF00436
(SSB) 		3 LEU A  67
ARG A  91
MET A 119
 None
 0.92A 4m11C-4dniA:
undetectable		 4m11C-4dniA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 LEU A 358
ARG A 359
MET A 129
 LEU  A 358 (-0.5A)
ARG  A 359 ( 0.6A)
MET  A 129 ( 0.0A)
 1.00A 4m11C-4flxA:
undetectable		 4m11C-4flxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF01403
(Sema) 		3 LEU A 262
ARG A 185
MET A  58
 None
EDO  A 616 ( 3.3A)
None
 0.99A 4m11C-4fwwA:
undetectable		 4m11C-4fwwA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2t SSFS6

(Streptomyces
sp. SF2575) 		PF00201
(UDPGT)
PF06722
(DUF1205) 		3 LEU A 153
ARG A  87
MET A  74
 None
 1.00A 4m11C-4g2tA:
undetectable		 4m11C-4g2tA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gip FUSION GLYCOPROTEIN
F1
FUSION GLYCOPROTEIN
F2

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		3 LEU A  94
ARG A  91
MET D 269
 None
 0.97A 4m11C-4gipA:
undetectable		 4m11C-4gipA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		3 LEU A 109
ARG A 106
MET A 452
 None
HEM  A 601 (-2.7A)
None
 0.87A 4m11C-4i8vA:
0.7		 4m11C-4i8vA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 LEU A 241
ARG A 272
MET A 407
 None
 0.88A 4m11C-4jhzA:
undetectable		 4m11C-4jhzA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkm BETA-GLUCURONIDASE

(Clostridium
perfringens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 LEU A 242
ARG A 274
MET A 406
 None
 0.97A 4m11C-4jkmA:
undetectable		 4m11C-4jkmA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1d SODIUM CHANNEL
SUBUNIT BETA-3

(Homo sapiens) 		PF07686
(V-set) 		3 LEU A 116
ARG A 115
MET A  25
 None
 0.93A 4m11C-4l1dA:
undetectable		 4m11C-4l1dA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		3 LEU A 337
ARG A 333
MET A 113
 None
 0.84A 4m11C-4n6kA:
undetectable		 4m11C-4n6kA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Psychrobacter
cryohalolentis) 		PF00561
(Abhydrolase_1) 		3 LEU A  97
ARG A  96
MET A  84
 None
 0.77A 4m11C-4ns4A:
undetectable		 4m11C-4ns4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Psychrobacter
cryohalolentis) 		PF00561
(Abhydrolase_1) 		3 LEU A 100
ARG A  96
MET A  84
 None
 0.99A 4m11C-4ns4A:
undetectable		 4m11C-4ns4A:
20.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 LEU A 118
ARG A 121
MET A 523
 None
BOG  A 604 ( 3.7A)
None
 0.56A 4m11C-4ph9A:
63.5		 4m11C-4ph9A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		3 LEU A 694
ARG A 693
MET A 360
 None
 0.87A 4m11C-4q2cA:
0.9		 4m11C-4q2cA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qr8 XAA-PRO DIPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		3 LEU A 244
ARG A 260
MET A 436
 None
 0.87A 4m11C-4qr8A:
undetectable		 4m11C-4qr8A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		no annotation 3 LEU B 262
ARG B 185
MET B  58
 None
 0.91A 4m11C-4qt8B:
undetectable		 4m11C-4qt8B:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE

(Sphaerobacter
thermophilus) 		no annotation 3 LEU B 153
ARG B 352
MET B 118
 None
 0.93A 4m11C-4ritB:
undetectable		 4m11C-4ritB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3k SPORE GERMINATION
PROTEIN YAAH

(Bacillus
megaterium) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		3 LEU A 401
ARG A 402
MET A 246
 None
SO4  A 501 (-2.9A)
None
 0.87A 4m11C-4s3kA:
undetectable		 4m11C-4s3kA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		3 LEU A1812
ARG A1808
MET A1675
 None
 0.82A 4m11C-4yknA:
undetectable		 4m11C-4yknA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 LEU A 288
ARG A 320
MET A 441
 None
 0.91A 4m11C-4ypjA:
undetectable		 4m11C-4ypjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z96 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF12436
(USP7_ICP0_bdg)
PF14533
(USP7_C2) 		3 LEU A 941
ARG A 940
MET A 988
 None
 0.93A 4m11C-4z96A:
undetectable		 4m11C-4z96A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaa FDC1

(Aspergillus
niger) 		PF01977
(UbiD) 		3 LEU A 430
ARG A 380
MET A 462
 None
 0.85A 4m11C-4zaaA:
undetectable		 4m11C-4zaaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbz URACIL-DNA
GLYCOSYLASE

(Sulfurisphaera
tokodaii) 		PF03167
(UDG) 		3 LEU A 106
ARG A 108
MET A   1
 None
 0.86A 4m11C-4zbzA:
undetectable		 4m11C-4zbzA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		3 LEU A 242
ARG A 258
MET A 433
 None
 0.83A 4m11C-4zwoA:
undetectable		 4m11C-4zwoA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomyces
pombe) 		PF01008
(IF-2B) 		3 LEU A 153
ARG A 122
MET A  35
 None
 0.86A 4m11C-5b04A:
2.4		 4m11C-5b04A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 LEU A 133
ARG A 134
MET A 378
 None
 0.90A 4m11C-5ci6A:
undetectable		 4m11C-5ci6A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxf ENVELOPE
GLYCOPROTEIN B

(Human
betaherpesvirus
5) 		PF00606
(Glycoprotein_B)
PF17416
(Glycoprot_B_PH1)
PF17417
(Glycoprot_B_PH2) 		3 LEU A 671
ARG A 672
MET A 683
 None
 0.79A 4m11C-5cxfA:
undetectable		 4m11C-5cxfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnf C-C MOTIF CHEMOKINE
5

(Homo sapiens) 		PF00048
(IL8) 		3 LEU A  19
ARG A  21
MET A  67
 None
 0.80A 4m11C-5dnfA:
undetectable		 4m11C-5dnfA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 LEU A  61
ARG A  62
MET A 666
 None
 0.85A 4m11C-5fp1A:
undetectable		 4m11C-5fp1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP42
EXOSOME COMPLEX
COMPONENT SKI6

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 LEU B  61
ARG B  60
MET E   1
 None
 0.84A 4m11C-5g06B:
undetectable		 4m11C-5g06B:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		3 LEU A 175
ARG A 174
MET A 103
 None
 0.97A 4m11C-5gjvA:
undetectable		 4m11C-5gjvA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h12 DEEP VENT DNA
POLYMERASE

(Pyrococcus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 LEU A 358
ARG A 359
MET A 129
 None
 0.94A 4m11C-5h12A:
undetectable		 4m11C-5h12A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		3 LEU A 606
ARG A 591
MET A 507
 None
 0.93A 4m11C-5hqbA:
undetectable		 4m11C-5hqbA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		3 LEU A 217
ARG A 219
MET A  68
 None
SO4  A 301 ( 4.2A)
None
 0.80A 4m11C-5hw3A:
undetectable		 4m11C-5hw3A:
18.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 LEU A 117
ARG A 120
MET A 522
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-4.2A)
 0.45A 4m11C-5ikrA:
37.0		 4m11C-5ikrA:
88.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		3 LEU A  57
ARG A 235
MET A 231
 None
 0.86A 4m11C-5jc8A:
undetectable		 4m11C-5jc8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		3 LEU A 394
ARG A 392
MET A 751
 None
 0.80A 4m11C-5jouA:
undetectable		 4m11C-5jouA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 LEU A  97
ARG A  42
MET A  28
 None
 0.98A 4m11C-5k3jA:
undetectable		 4m11C-5k3jA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1

(Homo sapiens) 		PF02230
(Abhydrolase_2) 		3 LEU A 161
ARG A 136
MET A  97
 None
 0.78A 4m11C-5kreA:
undetectable		 4m11C-5kreA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5med ARACHIDONATE
15-LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		3 LEU A 552
ARG A 551
MET A 374
 None
 0.94A 4m11C-5medA:
undetectable		 4m11C-5medA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 LEU A 196
ARG A 199
MET A 321
 None
 0.82A 4m11C-5mkkA:
undetectable		 4m11C-5mkkA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 3 LEU A  72
ARG A  73
MET A 682
 None
 0.97A 4m11C-5necA:
undetectable		 4m11C-5necA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A

(Methanothermococcus
thermolithotrophicus) 		PF00374
(NiFeSe_Hases) 		3 LEU F 335
ARG F 331
MET F 434
 None
 0.95A 4m11C-5odrF:
undetectable		 4m11C-5odrF:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2n I-ONUI_E-AG007820

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		3 LEU A 211
ARG A 207
MET A 138
 None
 0.99A 4m11C-5t2nA:
undetectable		 4m11C-5t2nA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 LEU A 776
ARG A 806
MET A 346
 None
 0.94A 4m11C-5t98A:
undetectable		 4m11C-5t98A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpr 3-DEHYDROQUINATE
SYNTHASE

(Trichormus
variabilis) 		PF01761
(DHQ_synthase) 		3 LEU A 346
ARG A 348
MET A 356
 SO4  A 505 (-4.7A)
None
None
 0.90A 4m11C-5tprA:
0.6		 4m11C-5tprA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ty0 ELONGATION FACTOR G

(Legionella
pneumophila) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		3 LEU A   5
ARG A  81
MET A 362
 None
 0.88A 4m11C-5ty0A:
undetectable		 4m11C-5ty0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7g CREB-BINDING PROTEIN

(Mus musculus) 		PF00439
(Bromodomain)
PF00569
(ZZ)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		3 LEU A1682
ARG A1683
MET A1291
 None
 0.93A 4m11C-5u7gA:
undetectable		 4m11C-5u7gA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uth THIOREDOXIN
REDUCTASE

(Mycolicibacterium
smegmatis) 		PF07992
(Pyr_redox_2) 		3 LEU A 248
ARG A 245
MET A  46
 FAD  A 400 (-4.6A)
FAD  A 400 ( 3.6A)
None
 0.97A 4m11C-5uthA:
undetectable		 4m11C-5uthA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		3 LEU A  67
ARG A  76
MET A  92
 None
 0.95A 4m11C-5x7sA:
undetectable		 4m11C-5x7sA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 3 LEU A 812
ARG A 808
MET A 675
 None
 0.82A 4m11C-5xgjA:
undetectable		 4m11C-5xgjA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 22

(Homo sapiens) 		no annotation 3 LEU A 604
ARG A 550
MET A 661
 None
 0.86A 4m11C-5y31A:
undetectable		 4m11C-5y31A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 3 LEU A 660
ARG A 659
MET A 467
 None
 0.81A 4m11C-5y3jA:
undetectable		 4m11C-5y3jA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 3 LEU A 267
ARG A 299
MET A 420
 None
 0.91A 4m11C-6b6lA:
undetectable		 4m11C-6b6lA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 3 LEU A 185
ARG A 762
MET A 804
 None
 0.79A 4m11C-6bfiA:
undetectable		 4m11C-6bfiA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft

() 		no annotation 3 LEU B 125
ARG B 126
MET A 385
 None
 0.97A 4m11C-6dftB:
undetectable		 4m11C-6dftB:
undetectable