SIMILAR PATTERNS OF AMINO ACIDS FOR 4M11_B_MXMB606_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e7s GDP-FUCOSE
SYNTHETASE

(Escherichia
coli) 		PF01370
(Epimerase) 		5 VAL A 245
LEU A 290
LEU A 212
ALA A 219
SER A 221
 None
 0.98A 4m11B-1e7sA:
0.0		 4m11B-1e7sA:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 MET A 113
VAL A 116
ARG A 120
ILE A 345
VAL A 349
LEU A 352
LEU A 359
TRP A 387
ALA A 527
LEU A 534
 None
None
SCL  A 700 (-3.9A)
None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
None
SCL  A 700 (-2.9A)
OAS  A 530 ( 3.3A)
 0.74A 4m11B-1ebvA:
57.9		 4m11B-1ebvA:
64.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 MET A 113
VAL A 116
ARG A 120
LEU A 352
ALA A 527
LEU A 531
LEU A 534
 None
None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
OAS  A 530 ( 3.3A)
 1.24A 4m11B-1ebvA:
57.9		 4m11B-1ebvA:
64.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyn BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		5 LEU P 269
LEU P 136
ALA P 156
LEU P 158
LEU P 128
 None
 1.03A 4m11B-1hynP:
0.0		 4m11B-1hynP:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA

(Treponema
pallidum) 		PF01297
(ZnuA) 		5 ARG A 266
ILE A 245
LEU A 259
ALA A 235
LEU A 242
 None
 1.00A 4m11B-1k0fA:
0.1		 4m11B-1k0fA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nz8 TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Thermus
thermophilus) 		PF02357
(NusG) 		5 VAL A  84
ARG A  25
ILE A  35
LEU A  31
LEU A  22
 None
 1.02A 4m11B-1nz8A:
undetectable		 4m11B-1nz8A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og6 HYPOTHETICAL
OXIDOREDUCTASE YDHF

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		5 ILE A  80
ALA A 110
SER A 113
LEU A 114
LEU A 117
 None
 0.85A 4m11B-1og6A:
0.0		 4m11B-1og6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxj RNA-BINDING PROTEIN
SMAUG

(Drosophila
melanogaster) 		PF00536
(SAM_1)
PF09246
(PHAT) 		5 MET A 625
TRP A 735
SER A 607
LEU A 605
LEU A 608
 None
 1.03A 4m11B-1oxjA:
undetectable		 4m11B-1oxjA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A  78
ILE A  18
VAL A  17
LEU A 146
LEU A  21
 None
 1.04A 4m11B-1poxA:
0.0		 4m11B-1poxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		5 LEU A 361
ALA A 295
SER A 298
LEU A 299
LEU A 302
 None
 0.95A 4m11B-1qfxA:
0.0		 4m11B-1qfxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qys TOP7

(-) 		no annotation 5 VAL A   6
ILE A  66
VAL A  70
LEU A  74
LEU A  67
 None
 1.02A 4m11B-1qysA:
undetectable		 4m11B-1qysA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1

(Mus musculus) 		PF03036
(Perilipin) 		5 ILE A 218
VAL A 241
LEU A 215
ALA A 254
LEU A 250
 None
 1.02A 4m11B-1sziA:
undetectable		 4m11B-1sziA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)

(Treponema
pallidum) 		PF01297
(ZnuA) 		5 ARG A 266
ILE A 245
LEU A 259
ALA A 235
LEU A 242
 None
 0.94A 4m11B-1toaA:
undetectable		 4m11B-1toaA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0o VON WILLEBRAND
FACTOR

(Mus musculus) 		PF00092
(VWA) 		5 ILE C 653
LEU C 619
ALA C 674
LEU C 676
LEU C 677
 None
 1.03A 4m11B-1u0oC:
undetectable		 4m11B-1u0oC:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5k HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02565
(RecO_C)
PF11967
(RecO_N) 		5 VAL A  25
ARG A  15
ILE A  11
LEU A  76
LEU A  52
 None
 1.04A 4m11B-1u5kA:
undetectable		 4m11B-1u5kA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori) 		PF01264
(Chorismate_synt) 		5 VAL A 243
ILE A 206
VAL A 291
ALA A 234
LEU A 339
 None
 1.06A 4m11B-1umfA:
undetectable		 4m11B-1umfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v32 HYPOTHETICAL PROTEIN
RAFL09-47-K03

(Arabidopsis
thaliana) 		PF02201
(SWIB) 		5 ILE A  77
VAL A  62
LEU A  54
LEU A  68
ALA A  45
 None
 1.06A 4m11B-1v32A:
undetectable		 4m11B-1v32A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu7 HISTIDYL-TRNA
SYNTHETASE

(Thermoplasma
acidophilum) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 ILE A 317
VAL A 316
LEU A 320
ALA A 286
LEU A 288
 None
 1.01A 4m11B-1wu7A:
undetectable		 4m11B-1wu7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0y FRV OPERON PROTEIN
FRVX

(Pyrococcus
horikoshii) 		PF05343
(Peptidase_M42) 		5 VAL A 334
VAL A  15
LEU A  12
ALA A 186
LEU A 191
 None
 1.00A 4m11B-1y0yA:
undetectable		 4m11B-1y0yA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		5 ILE A 355
VAL A 322
LEU A 265
LEU A 326
LEU A 351
 None
 0.91A 4m11B-1z6rA:
undetectable		 4m11B-1z6rA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 ILE A 244
VAL A 240
LEU A 256
ALA A 267
SER A 269
 None
 1.03A 4m11B-1zczA:
undetectable		 4m11B-1zczA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4k 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		5 ILE A   9
LEU A  33
ALA A 214
LEU A 218
LEU A 221
 None
 0.93A 4m11B-2a4kA:
undetectable		 4m11B-2a4kA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0c PUTATIVE PHOSPHATASE

(Escherichia
coli) 		PF13419
(HAD_2) 		6 ILE A  11
VAL A 111
LEU A 113
ALA A 160
LEU A 158
LEU A   9
 None
 1.41A 4m11B-2b0cA:
undetectable		 4m11B-2b0cA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb6 TRANSCOBALAMIN II

(Bos taurus) 		PF01122
(Cobalamin_bind) 		5 ILE A 290
VAL A 287
ALA A 187
SER A 189
LEU A 193
 None
 1.03A 4m11B-2bb6A:
0.2		 4m11B-2bb6A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		5 VAL A 199
VAL A 132
ALA A 146
LEU A 150
LEU A 153
 None
 1.01A 4m11B-2bxyA:
undetectable		 4m11B-2bxyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e11 HYDROLASE

(Xanthomonas
campestris) 		PF00795
(CN_hydrolase) 		5 LEU A  38
LEU A  41
ALA A  98
LEU A  96
LEU A  95
 None
 0.84A 4m11B-2e11A:
undetectable		 4m11B-2e11A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e44 INSULIN-LIKE GROWTH
FACTOR 2 MRNA
BINDING PROTEIN 3

(Homo sapiens) 		PF00076
(RRM_1) 		5 ILE A  85
VAL A 124
ALA A 132
LEU A 136
LEU A 139
 None
 0.97A 4m11B-2e44A:
undetectable		 4m11B-2e44A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbm TOP7 FOLD PROTEIN
TOP7M13

(synthetic
construct) 		no annotation 5 VAL A   8
ILE A  80
VAL A  84
LEU A  88
LEU A  81
 None
 1.02A 4m11B-2mbmA:
undetectable		 4m11B-2mbmA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n3d BACTOFILIN A

(Caulobacter
vibrioides) 		PF04519
(Bactofilin) 		5 ILE A  60
ALA A  39
SER A  40
LEU A  41
LEU A  42
 None
 1.05A 4m11B-2n3dA:
undetectable		 4m11B-2n3dA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n6j ZINC METALLOPROTEASE
ZMP1

(Clostridioides
difficile) 		PF07737
(ATLF) 		5 MET A  57
ILE A  79
VAL A 121
LEU A 123
ALA A 145
 None
 1.05A 4m11B-2n6jA:
undetectable		 4m11B-2n6jA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 VAL A 324
ILE A 375
LEU A 433
ALA A 362
LEU A 370
 None
 0.86A 4m11B-2p54A:
undetectable		 4m11B-2p54A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		5 ILE A 330
VAL A 412
LEU A 415
ALA A 255
LEU A 252
 None
 1.03A 4m11B-2pqdA:
undetectable		 4m11B-2pqdA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8q IRON-REGULATED
SURFACE DETERMINANT
E

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		5 ILE A 171
VAL A 169
LEU A 225
ALA A 195
LEU A 191
 None
 0.98A 4m11B-2q8qA:
undetectable		 4m11B-2q8qA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 VAL A1052
LEU A1056
LEU A1049
LEU A1022
LEU A1000
 None
 0.90A 4m11B-2vdcA:
undetectable		 4m11B-2vdcA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		5 ILE A 113
VAL A 150
LEU A 115
LEU A 332
LEU A 335
 None
 0.97A 4m11B-2x24A:
undetectable		 4m11B-2x24A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvx MG2+ TRANSPORTER
MGTE

(Thermus
thermophilus) 		PF00571
(CBS)
PF01769
(MgtE)
PF03448
(MgtE_N) 		5 ILE A 171
VAL A 145
LEU A 184
LEU A 155
LEU A 158
 None
 1.01A 4m11B-2yvxA:
undetectable		 4m11B-2yvxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		5 ILE A 236
LEU A 217
LEU A 261
ALA A 229
SER A 233
 None
 0.99A 4m11B-2z6gA:
undetectable		 4m11B-2z6gA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc8 N-ACYLAMINO ACID
RACEMASE

(Thermus
thermophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 176
ARG A 177
ILE A 164
LEU A 162
LEU A 207
 None
 1.05A 4m11B-2zc8A:
undetectable		 4m11B-2zc8A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at6 BETA-GLOBIN

(Podocnemis
unifilis) 		PF00042
(Globin) 		6 VAL B  67
ILE B 109
VAL B 113
LEU B 110
ALA B  25
LEU B  28
 HEM  B 147 ( 3.9A)
None
None
None
None
None
 1.26A 4m11B-3at6B:
undetectable		 4m11B-3at6B:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		5 ILE A  68
LEU A 170
ALA A 257
LEU A 261
LEU A 264
 None
 1.01A 4m11B-3fmcA:
undetectable		 4m11B-3fmcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		5 ILE A 241
LEU A 250
ALA A 126
SER A 127
LEU A 129
 None
None
GOL  A   1 (-4.3A)
MLA  A 302 ( 4.5A)
None
 1.05A 4m11B-3fssA:
undetectable		 4m11B-3fssA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Mus musculus) 		PF00079
(Serpin) 		6 MET A 298
VAL A 317
VAL A  42
LEU A  46
ALA A 340
LEU A 286
 None
 1.40A 4m11B-3lw2A:
undetectable		 4m11B-3lw2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6i L-ARABINITOL
4-DEHYDROGENASE

(Neurospora
crassa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 320
ILE A 194
LEU A 172
LEU A 165
ALA A 201
 None
 1.02A 4m11B-3m6iA:
0.4		 4m11B-3m6iA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwi ZINC TRANSPORT
PROTEIN ZNTB

(Salmonella
enterica) 		PF01544
(CorA) 		5 MET A 109
VAL A 132
LEU A 136
LEU A 129
LEU A 149
 None
 0.85A 4m11B-3nwiA:
undetectable		 4m11B-3nwiA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwp 6-PHOSPHOGLUCONOLACT
ONASE

(Shewanella
baltica) 		PF01182
(Glucosamine_iso) 		5 ILE A 188
VAL A 132
LEU A 134
ALA A 181
LEU A 183
 None
 0.94A 4m11B-3nwpA:
undetectable		 4m11B-3nwpA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		6 VAL A 114
LEU A  15
ALA A  59
SER A  60
LEU A  96
LEU A  62
 None
 1.10A 4m11B-3nwrA:
undetectable		 4m11B-3nwrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onk EPSIN-3

(Saccharomyces
cerevisiae) 		PF01417
(ENTH) 		5 ILE A  68
VAL A  36
ALA A  90
LEU A  94
LEU A  97
 None
 0.94A 4m11B-3onkA:
undetectable		 4m11B-3onkA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqh PUTATIVE
UNCHARACTERIZED
PROTEIN YVMC

(Bacillus
licheniformis) 		PF16715
(CDPS) 		5 VAL A 221
ILE A 182
VAL A 181
LEU A 185
ALA A 146
 None
 1.03A 4m11B-3oqhA:
undetectable		 4m11B-3oqhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p01 TWO-COMPONENT
RESPONSE REGULATOR

(Nostoc sp. PCC
7120) 		PF13185
(GAF_2) 		6 ILE A 183
LEU A 281
LEU A 198
ALA A 301
SER A 300
LEU A 166
 None
 1.21A 4m11B-3p01A:
undetectable		 4m11B-3p01A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqw PUTATIVE CITRATE
LYASE

(Cupriavidus
pinatubonensis) 		PF03328
(HpcH_HpaI) 		5 ILE A 151
VAL A 160
LEU A 157
ALA A 212
LEU A 172
 None
 1.02A 4m11B-3qqwA:
undetectable		 4m11B-3qqwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Lactobacillus
acidophilus) 		PF00215
(OMPdecase) 		5 ILE A  57
VAL A  34
LEU A  59
ALA A  42
LEU A  50
 None
 1.02A 4m11B-3tfxA:
undetectable		 4m11B-3tfxA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uan HEPARAN SULFATE
GLUCOSAMINE
3-O-SULFOTRANSFERASE
1

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		6 VAL A 235
ILE A  63
VAL A 121
LEU A 147
SER A  79
LEU A  75
 None
 1.39A 4m11B-3uanA:
undetectable		 4m11B-3uanA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdb PROBABLE
ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT

(Mycobacterium
tuberculosis) 		PF02861
(Clp_N) 		5 ILE A  54
LEU A  35
LEU A  49
ALA A 120
LEU A 127
 None
 0.88A 4m11B-3wdbA:
undetectable		 4m11B-3wdbA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		5 ILE A 305
VAL A 110
ALA A 134
LEU A 138
LEU A 141
 None
 0.96A 4m11B-4djiA:
0.9		 4m11B-4djiA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 ILE A 438
VAL A 442
LEU A 439
SER A 343
LEU A 342
 None
 0.92A 4m11B-4f7zA:
undetectable		 4m11B-4f7zA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A1089
VAL A1185
LEU A1187
SER A1172
LEU A1169
 None
 1.03A 4m11B-4fodA:
undetectable		 4m11B-4fodA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		5 ILE A 231
VAL A 235
LEU A 239
LEU A 232
ALA A 257
 None
 1.05A 4m11B-4g1cA:
undetectable		 4m11B-4g1cA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ge0 UNCHARACTERIZED
PROTEIN C22E12.03C

(Schizosaccharomyces
pombe) 		PF01965
(DJ-1_PfpI) 		5 ILE A  23
LEU A 172
ALA A 183
SER A 187
LEU A 188
 None
 1.04A 4m11B-4ge0A:
undetectable		 4m11B-4ge0A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grs PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE,
2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus;
Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 VAL A 297
ILE A 281
LEU A 329
LEU A 322
ALA A 287
 None
 1.04A 4m11B-4grsA:
undetectable		 4m11B-4grsA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ita SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Synechococcus
sp. PCC 7002) 		PF00171
(Aldedh) 		5 ILE A 194
LEU A 125
ALA A 210
SER A 213
LEU A 217
 None
None
NDP  A 501 (-3.2A)
NDP  A 501 (-3.3A)
None
 1.04A 4m11B-4itaA:
undetectable		 4m11B-4itaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ita SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Synechococcus
sp. PCC 7002) 		PF00171
(Aldedh) 		5 ILE A 194
VAL A 190
LEU A 125
ALA A 210
LEU A 217
 None
NDP  A 501 ( 4.4A)
None
NDP  A 501 (-3.2A)
None
 1.02A 4m11B-4itaA:
undetectable		 4m11B-4itaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 633
VAL A 623
LEU A 563
LEU A 618
ALA A 598
 None
 1.06A 4m11B-4k33A:
undetectable		 4m11B-4k33A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lj2 CHORISMATE SYNTHASE

(Acinetobacter
baumannii) 		PF01264
(Chorismate_synt) 		5 VAL A 240
ILE A 209
VAL A 288
ALA A 231
LEU A 336
 None
 1.04A 4m11B-4lj2A:
undetectable		 4m11B-4lj2A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m29 BETA-XYLOSIDASE

(Caulobacter
vibrioides) 		PF01229
(Glyco_hydro_39) 		5 VAL A 223
ILE A 266
VAL A 209
LEU A 213
LEU A 276
 None
 1.03A 4m11B-4m29A:
undetectable		 4m11B-4m29A:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 MET A 114
VAL A 117
ARG A 121
ILE A 346
LEU A 353
LEU A 360
TRP A 388
ALA A 528
LEU A 535
 None
BOG  A 604 (-3.9A)
BOG  A 604 ( 3.7A)
None
IBP  A 601 ( 4.7A)
IBP  A 601 ( 4.7A)
None
IBP  A 601 (-3.4A)
EDO  A 616 ( 4.4A)
 0.71A 4m11B-4ph9A:
63.5		 4m11B-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 MET A 114
VAL A 117
ARG A 121
ILE A 346
LEU A 353
LEU A 532
LEU A 535
 None
BOG  A 604 (-3.9A)
BOG  A 604 ( 3.7A)
None
IBP  A 601 ( 4.7A)
IBP  A 601 ( 4.9A)
EDO  A 616 ( 4.4A)
 1.24A 4m11B-4ph9A:
63.5		 4m11B-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 MET A 114
VAL A 117
ARG A 121
ILE A 346
VAL A 350
LEU A 360
TRP A 388
ALA A 528
LEU A 535
 None
BOG  A 604 (-3.9A)
BOG  A 604 ( 3.7A)
None
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
None
IBP  A 601 (-3.4A)
EDO  A 616 ( 4.4A)
 0.53A 4m11B-4ph9A:
63.5		 4m11B-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		8 MET A 114
VAL A 117
ARG A 121
LEU A 353
LEU A 360
TRP A 388
ALA A 528
SER A 531
 None
BOG  A 604 (-3.9A)
BOG  A 604 ( 3.7A)
IBP  A 601 ( 4.7A)
IBP  A 601 ( 4.7A)
None
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
 0.87A 4m11B-4ph9A:
63.5		 4m11B-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 MET A 114
VAL A 117
ARG A 121
LEU A 353
SER A 531
LEU A 532
 None
BOG  A 604 (-3.9A)
BOG  A 604 ( 3.7A)
IBP  A 601 ( 4.7A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 1.40A 4m11B-4ph9A:
63.5		 4m11B-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		8 MET A 114
VAL A 117
ARG A 121
VAL A 350
LEU A 360
TRP A 388
ALA A 528
SER A 531
 None
BOG  A 604 (-3.9A)
BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
None
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
 0.73A 4m11B-4ph9A:
63.5		 4m11B-4ph9A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY

(Shewanella
oneidensis) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		5 MET A 201
ILE A 381
LEU A 374
ALA A 296
LEU A 301
 None
 0.97A 4m11B-4pu5A:
undetectable		 4m11B-4pu5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)

(Methylobacterium
extorquens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ILE A 169
LEU A 166
ALA A 200
LEU A 198
LEU A 196
 None
 0.95A 4m11B-4px1A:
1.2		 4m11B-4px1A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2n INAD-LIKE PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		6 VAL A 366
ILE A 418
VAL A 397
LEU A 449
ALA A 406
LEU A 376
 None
 1.36A 4m11B-4q2nA:
undetectable		 4m11B-4q2nA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		5 ILE A  80
ALA A 110
SER A 113
LEU A 114
LEU A 117
 None
 0.86A 4m11B-4r9oA:
undetectable		 4m11B-4r9oA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		5 VAL A1013
ILE A1047
VAL A1065
LEU A1045
LEU A1075
 None
 1.05A 4m11B-4u48A:
undetectable		 4m11B-4u48A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE

(Haemophilus
influenzae) 		PF00106
(adh_short) 		5 VAL A 271
ILE A 164
LEU A 252
LEU A 259
ALA A 210
 None
 1.03A 4m11B-4wuvA:
undetectable		 4m11B-4wuvA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x68 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00144
(Beta-lactamase) 		6 ILE A  58
VAL A  56
LEU A  54
LEU A 363
ALA A  41
LEU A  37
 None
 1.05A 4m11B-4x68A:
undetectable		 4m11B-4x68A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxf MUPS

(Pseudomonas
fluorescens) 		PF13561
(adh_short_C2) 		6 ILE A  25
VAL A  85
LEU A 132
ALA A 138
LEU A 140
LEU A  95
 None
 1.37A 4m11B-4yxfA:
undetectable		 4m11B-4yxfA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zal UBIX

(Pseudomonas
aeruginosa) 		PF02441
(Flavoprotein) 		5 ILE A   7
VAL A  99
LEU A   9
LEU A 187
LEU A 190
 None
 1.04A 4m11B-4zalA:
undetectable		 4m11B-4zalA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anc RIBOSOME MATURATION
PROTEIN SBDS

(Homo sapiens) 		PF01172
(SBDS)
PF09377
(SBDS_C) 		5 VAL J 120
ILE J 158
VAL J 157
LEU J 161
ALA J 112
 None
 1.04A 4m11B-5ancJ:
undetectable		 4m11B-5ancJ:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2

(Mus musculus) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 VAL A 354
VAL A 239
ALA A 300
SER A 304
LEU A 331
 None
 1.01A 4m11B-5cm9A:
undetectable		 4m11B-5cm9A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19

(Escherichia
coli;
Tetrahymena
thermophila) 		PF13416
(SBP_bac_8) 		5 ILE A 409
VAL A 407
LEU A 383
LEU A 507
LEU A 509
 None
None
None
GOL  A 607 (-4.1A)
None
 1.04A 4m11B-5dfmA:
undetectable		 4m11B-5dfmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine leukemia
virus) 		PF00075
(RNase_H)
PF00078
(RVT_1) 		5 ILE A 564
LEU A 563
ALA A 558
SER A 527
LEU A 552
 None
 1.04A 4m11B-5dmqA:
undetectable		 4m11B-5dmqA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei0 SERPIN A12

(Homo sapiens) 		PF00079
(Serpin) 		5 MET A 202
LEU A 138
ALA A  82
LEU A  86
LEU A  88
 None
 1.02A 4m11B-5ei0A:
undetectable		 4m11B-5ei0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A1039
VAL A1029
LEU A 986
LEU A1024
ALA A1004
 None
 1.02A 4m11B-5f1zA:
undetectable		 4m11B-5f1zA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF02861
(Clp_N) 		5 ILE A 147
LEU A 128
LEU A 142
ALA A 213
LEU A 220
 None
 0.94A 4m11B-5guiA:
undetectable		 4m11B-5guiA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmm EXODEOXYRIBONUCLEASE

(Escherichia
virus T5) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		6 ILE A 212
VAL A 209
LEU A 252
LEU A 246
ALA A 197
LEU A 195
 None
 1.44A 4m11B-5hmmA:
undetectable		 4m11B-5hmmA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id4 DSBA-LIKE PROTEIN

(Proteus
mirabilis) 		PF13462
(Thioredoxin_4) 		5 VAL A 206
ILE A 197
VAL A 215
LEU A  94
LEU A  76
 None
 1.05A 4m11B-5id4A:
1.0		 4m11B-5id4A:
17.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 MET A 113
VAL A 116
ARG A 120
ILE A 345
ALA A 527
LEU A 531
LEU A 534
 None
None
ID8  A 601 ( 4.4A)
None
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
None
 1.02A 4m11B-5ikrA:
62.4		 4m11B-5ikrA:
88.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 MET A 113
VAL A 116
ARG A 120
ILE A 345
VAL A 349
LEU A 352
LEU A 359
TRP A 387
ALA A 527
SER A 530
LEU A 534
 None
None
ID8  A 601 ( 4.4A)
None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
None
 0.58A 4m11B-5ikrA:
62.4		 4m11B-5ikrA:
88.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Mycolicibacterium
thermoresistibile) 		PF00982
(Glyco_transf_20) 		5 VAL A 122
VAL A  15
LEU A 147
ALA A 129
LEU A 154
 None
 0.93A 4m11B-5jijA:
undetectable		 4m11B-5jijA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		5 VAL A1369
LEU A1260
ALA A1647
SER A1643
LEU A1644
 None
 1.04A 4m11B-5lkzA:
1.9		 4m11B-5lkzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 VAL B 485
ARG B 468
VAL B 757
LEU B 492
LEU B 805
 None
 1.01A 4m11B-5my0B:
undetectable		 4m11B-5my0B:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD) 		5 VAL J 463
VAL J 452
LEU J 404
LEU J 454
LEU J 356
 None
 1.06A 4m11B-5nilJ:
undetectable		 4m11B-5nilJ:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria) 		no annotation 5 VAL A 326
ILE A 293
VAL A 265
LEU A 292
ALA A 302
 None
 1.03A 4m11B-5o3wA:
undetectable		 4m11B-5o3wA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vai UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF00002
(7tm_2)
PF02793
(HRM) 		5 ILE R 188
LEU R 192
ALA R 153
SER R 155
LEU R 159
 None
 1.02A 4m11B-5vaiR:
undetectable		 4m11B-5vaiR:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 ILE A1019
VAL A1009
LEU A 964
LEU A1004
ALA A 984
 None
 0.97A 4m11B-6c7yA:
undetectable		 4m11B-6c7yA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enx NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL

(Danio rerio) 		no annotation 5 ILE A 227
VAL A 231
LEU A 235
LEU A 228
ALA A 253
 None
 1.05A 4m11B-6enxA:
undetectable		 4m11B-6enxA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 5 ILE A  90
VAL A  23
LEU A  87
ALA A  68
LEU A  39
 None
 1.01A 4m11B-6fikA:
undetectable		 4m11B-6fikA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gy6 -

(-) 		no annotation 5 VAL B 121
LEU B  71
ALA B 312
LEU B 315
LEU B 331
 None
 0.92A 4m11B-6gy6B:
undetectable		 4m11B-6gy6B:
undetectable