SIMILAR PATTERNS OF AMINO ACIDS FOR 4M11_A_MXMA606_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		5 LEU A 178
ILE A 159
VAL A 276
ALA A 339
LEU A 338
 None
 1.41A 4m11A-1a2oA:
0.0		 4m11A-1a2oA:
20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 ARG A 120
ILE A 345
LEU A 352
LEU A 359
TRP A 387
MET A 522
ALA A 527
 SCL  A 700 (-3.9A)
None
SCL  A 700 ( 4.8A)
None
None
None
SCL  A 700 (-2.9A)
 0.64A 4m11A-1ebvA:
57.9		 4m11A-1ebvA:
64.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		8 MET A 113
ARG A 120
ILE A 345
VAL A 349
LEU A 359
TRP A 387
MET A 522
ALA A 527
 None
SCL  A 700 (-3.9A)
None
SCL  A 700 ( 4.6A)
None
None
None
SCL  A 700 (-2.9A)
 0.51A 4m11A-1ebvA:
57.9		 4m11A-1ebvA:
64.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 MET A 113
LEU A 117
ARG A 120
ILE A 345
LEU A 359
MET A 522
ALA A 527
 None
None
SCL  A 700 (-3.9A)
None
None
None
SCL  A 700 (-2.9A)
 0.66A 4m11A-1ebvA:
57.9		 4m11A-1ebvA:
64.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP

(Salmonella
enterica) 		PF00102
(Y_phosphatase)
PF03545
(YopE) 		5 MET S 533
LEU S 497
LEU S 375
LEU S 451
MET S 478
 None
 1.42A 4m11A-1g4uS:
0.0		 4m11A-1g4uS:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he9 EXOENZYME S

(Pseudomonas
aeruginosa) 		PF03545
(YopE) 		5 LEU A 181
MET A 112
ALA A 151
SER A 147
LEU A 148
 None
 1.44A 4m11A-1he9A:
undetectable		 4m11A-1he9A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		5 MET A 238
ILE A 214
VAL A   8
LEU A   6
ALA A 230
 None
PO4  A1002 (-4.4A)
None
None
None
 1.29A 4m11A-1ixpA:
0.0		 4m11A-1ixpA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 305
VAL A 320
LEU A 274
LEU A 315
LEU A 248
 None
 1.25A 4m11A-1k9aA:
0.0		 4m11A-1k9aA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00117
(GATase) 		5 ILE H   8
VAL H  45
LEU H  79
ALA H  18
LEU H  15
 None
 1.45A 4m11A-1ka9H:
0.0		 4m11A-1ka9H:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrk YGFZ PROTEIN

(Escherichia
coli) 		PF01571
(GCV_T) 		5 ILE A 194
LEU A 258
LEU A 190
ALA A 261
LEU A 280
 None
 1.12A 4m11A-1nrkA:
0.0		 4m11A-1nrkA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rja TYROSINE-PROTEIN
KINASE 6

(Homo sapiens) 		PF00017
(SH2) 		5 LEU A  18
VAL A  78
LEU A  77
LEU A  92
LEU A  29
 None
 1.35A 4m11A-1rjaA:
undetectable		 4m11A-1rjaA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v32 HYPOTHETICAL PROTEIN
RAFL09-47-K03

(Arabidopsis
thaliana) 		PF02201
(SWIB) 		5 LEU A  86
VAL A  62
LEU A  54
LEU A  68
ALA A  45
 None
 1.41A 4m11A-1v32A:
undetectable		 4m11A-1v32A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Escherichia
coli) 		PF00290
(Trp_syntA) 		5 LEU A  25
ILE A  37
LEU A  34
ALA A  86
LEU A  85
 None
 1.05A 4m11A-1xcfA:
undetectable		 4m11A-1xcfA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 MET A 296
ILE A 187
VAL A 185
LEU A 255
LEU A 219
 None
 1.14A 4m11A-1xi8A:
undetectable		 4m11A-1xi8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y13 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Plasmodium
falciparum) 		PF01242
(PTPS) 		5 MET A 142
LEU A 147
ARG A 150
VAL A  16
LEU A  67
 None
 1.16A 4m11A-1y13A:
undetectable		 4m11A-1y13A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yii ANNEXIN A5

(Gallus gallus) 		PF00191
(Annexin) 		5 MET A  81
LEU A  42
LEU A  73
ALA A  27
LEU A  24
 None
 1.32A 4m11A-1yiiA:
0.5		 4m11A-1yiiA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbr CONSERVED
HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		5 LEU A  65
LEU A 281
LEU A  18
ALA A  44
LEU A  46
 None
 1.38A 4m11A-1zbrA:
undetectable		 4m11A-1zbrA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 LEU A 361
LEU A 339
LEU A 357
ALA A 367
LEU A 365
 SO4  A 502 (-4.3A)
None
None
None
None
 1.34A 4m11A-2douA:
undetectable		 4m11A-2douA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36

(Canis lupus) 		PF03388
(Lectin_leg-like) 		5 LEU A 135
ILE A 268
VAL A  88
LEU A  83
LEU A  90
 None
 1.36A 4m11A-2dupA:
undetectable		 4m11A-2dupA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eis HYPOTHETICAL PROTEIN
TTHB207

(Thermus
thermophilus) 		PF03061
(4HBT) 		5 VAL A  60
LEU A  21
TRP A  29
ALA A 101
LEU A  99
 None
 1.41A 4m11A-2eisA:
undetectable		 4m11A-2eisA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 LEU A  95
VAL A 327
LEU A 264
ALA A 282
LEU A 283
 None
 1.45A 4m11A-2eo5A:
undetectable		 4m11A-2eo5A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fxv XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran) 		5 MET A  35
LEU A  20
LEU A  26
ALA A 176
LEU A 175
 None
 1.46A 4m11A-2fxvA:
undetectable		 4m11A-2fxvA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g39 ACETYL-COA HYDROLASE

(Pseudomonas
aeruginosa) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 LEU A 257
VAL A 271
LEU A 240
ALA A 262
LEU A 260
 None
 1.49A 4m11A-2g39A:
undetectable		 4m11A-2g39A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn4 UDP-GLCNAC C6
DEHYDRATASE

(Helicobacter
pylori) 		PF02719
(Polysacc_synt_2) 		5 MET A 237
LEU A 324
VAL A 182
LEU A 242
LEU A 332
 None
 1.34A 4m11A-2gn4A:
undetectable		 4m11A-2gn4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		5 ILE A 653
VAL A 658
LEU A 662
LEU A 648
LEU A 643
 None
 1.41A 4m11A-2gq3A:
undetectable		 4m11A-2gq3A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1r DIMETHYLADENOSINE
TRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00398
(RrnaAD) 		5 LEU A 105
ILE A  28
LEU A  39
LEU A  26
LEU A 117
 None
 1.30A 4m11A-2h1rA:
undetectable		 4m11A-2h1rA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE

(Trichormus
variabilis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 LEU A 104
ILE A  81
VAL A  84
LEU A 117
ALA A  96
 None
None
COA  A 500 (-3.8A)
None
COA  A 500 (-3.3A)
 1.44A 4m11A-2ozgA:
undetectable		 4m11A-2ozgA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		5 LEU A 281
ILE A 330
VAL A 412
LEU A 415
LEU A 252
 None
 0.95A 4m11A-2pqdA:
undetectable		 4m11A-2pqdA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 834
VAL A 849
LEU A 804
LEU A 844
LEU A 780
 None
 1.23A 4m11A-2r4bA:
undetectable		 4m11A-2r4bA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A  14
LEU A 256
ALA A 288
SER A 284
LEU A 287
 None
 1.30A 4m11A-2x3eA:
undetectable		 4m11A-2x3eA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anp TRANSCRIPTIONAL
REPRESSOR, TETR
FAMILY

(Thermus
thermophilus) 		no annotation 5 LEU C 186
LEU C  65
LEU C  89
ALA C 159
LEU C 158
 None
 1.28A 4m11A-3anpC:
undetectable		 4m11A-3anpC:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ap1 PROTEIN-TYROSINE
SULFOTRANSFERASE 2

(Homo sapiens) 		PF13469
(Sulfotransfer_3) 		5 MET A 181
LEU A 179
LEU A 241
ALA A  86
LEU A  88
 None
 1.31A 4m11A-3ap1A:
undetectable		 4m11A-3ap1A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 305
VAL A 320
LEU A 274
LEU A 315
LEU A 248
 None
 1.25A 4m11A-3d7uA:
undetectable		 4m11A-3d7uA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE

(Bacillus cereus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 103
LEU A   4
ALA A  40
SER A  36
LEU A  39
 None
 1.44A 4m11A-3dhvA:
undetectable		 4m11A-3dhvA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnp STRESS RESPONSE
PROTEIN YHAX

(Bacillus
subtilis) 		PF08282
(Hydrolase_3) 		5 MET A 230
ILE A  64
VAL A 207
LEU A 211
LEU A 204
 None
 1.48A 4m11A-3dnpA:
undetectable		 4m11A-3dnpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Burkholderia
pseudomallei) 		PF03740
(PdxJ) 		5 MET A 245
ILE A 221
VAL A  15
LEU A  13
ALA A 237
 None
 1.32A 4m11A-3gk0A:
undetectable		 4m11A-3gk0A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn2 2-DEHYDROPANTOATE
2-REDUCTASE

(Geobacter
metallireducens) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 MET A 163
LEU A 160
ILE A   3
LEU A  19
LEU A  98
 None
 1.08A 4m11A-3hn2A:
undetectable		 4m11A-3hn2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		5 MET A 341
LEU A 359
LEU A 337
MET A 299
ALA A 295
 None
 1.49A 4m11A-3hxwA:
1.0		 4m11A-3hxwA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixl ARYLMALONATE
DECARBOXYLASE

(Bordetella
bronchiseptica) 		no annotation 5 VAL A 209
LEU A 236
LEU A 185
ALA A 107
LEU A 109
 None
 1.37A 4m11A-3ixlA:
undetectable		 4m11A-3ixlA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermus
thermophilus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 LEU F 169
LEU F 280
LEU F 287
ALA F  63
LEU F  66
 None
 1.22A 4m11A-3kfuF:
undetectable		 4m11A-3kfuF:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw8 PUTATIVE COPPER
OXIDASE

(Streptomyces
coelicolor) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 MET A  53
LEU A  51
VAL A 103
LEU A 101
LEU A  87
 None
 1.23A 4m11A-3kw8A:
undetectable		 4m11A-3kw8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A

(Shewanella
denitrificans) 		PF00246
(Peptidase_M14) 		5 LEU A 269
VAL A 370
LEU A 330
ALA A 292
LEU A 293
 None
 1.34A 4m11A-3l2nA:
undetectable		 4m11A-3l2nA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmz PUTATIVE SUGAR
ISOMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		5 ILE A  70
LEU A  65
ALA A  49
SER A 255
LEU A 256
 None
 1.10A 4m11A-3lmzA:
undetectable		 4m11A-3lmzA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1a PUTATIVE
DEHYDROGENASE

(Streptomyces
avermitilis) 		PF00106
(adh_short) 		5 MET A 125
LEU A 122
ALA A 166
SER A 162
LEU A 165
 None
 1.21A 4m11A-3m1aA:
undetectable		 4m11A-3m1aA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacteroides
thetaiotaomicron) 		PF08543
(Phos_pyr_kin) 		5 MET A 132
VAL A  12
LEU A  40
LEU A  85
TRP A  70
 None
 1.38A 4m11A-3mbhA:
undetectable		 4m11A-3mbhA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 MET A  56
LEU A  12
VAL A 388
LEU A 378
LEU A 383
 None
 1.39A 4m11A-3n2cA:
undetectable		 4m11A-3n2cA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfv ALGINATE LYASE

(Bacteroides
ovatus) 		PF05426
(Alginate_lyase) 		5 MET A 303
LEU A 300
ILE A 277
LEU A 273
LEU A 332
 None
 1.33A 4m11A-3nfvA:
undetectable		 4m11A-3nfvA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		5 MET A 184
LEU A 301
VAL A 216
LEU A 220
ALA A 204
 None
 1.33A 4m11A-3qbdA:
undetectable		 4m11A-3qbdA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Anaerococcus
prevotii) 		PF00215
(OMPdecase) 		5 ILE A 221
VAL A 199
LEU A 151
LEU A 237
MET A 179
 None
 1.48A 4m11A-3r89A:
undetectable		 4m11A-3r89A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rys ADENOSINE DEAMINASE
1

(Paenarthrobacter
aurescens) 		PF00962
(A_deaminase) 		5 LEU A 125
ARG A  84
ILE A  22
LEU A  30
LEU A  87
 None
 1.26A 4m11A-3rysA:
undetectable		 4m11A-3rysA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sn0 PUTATIVE
L-ALANINE-DL-GLUTAMA
TE EPIMERASE

(Paraburkholderia
xenovorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 244
VAL A 242
LEU A 239
LEU A 218
SER A 259
 None
 1.07A 4m11A-3sn0A:
undetectable		 4m11A-3sn0A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr6 O-METHYLTRANSFERASE

(Coxiella
burnetii) 		PF01596
(Methyltransf_3) 		5 LEU A  30
LEU A 119
ALA A 100
SER A  98
LEU A 101
 None
None
None
SAH  A 224 ( 4.5A)
None
 1.47A 4m11A-3tr6A:
undetectable		 4m11A-3tr6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unv ADMH

(Pantoea
agglomerans) 		PF00221
(Lyase_aromatic) 		5 LEU A 174
LEU A 147
MET A 225
ALA A 127
SER A 131
 None
 1.19A 4m11A-3unvA:
0.3		 4m11A-3unvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uz0 STAGE II SPORULATION
PROTEIN Q
STAGE III
SPORULATION PROTEIN
AH

(Bacillus
subtilis) 		PF01551
(Peptidase_M23)
PF12685
(SpoIIIAH) 		5 ILE A 181
VAL A 210
LEU B 118
ALA A 201
LEU A 199
 None
 1.33A 4m11A-3uz0A:
undetectable		 4m11A-3uz0A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 ILE A 438
VAL A 442
LEU A 439
SER A 343
LEU A 342
 None
 0.94A 4m11A-4f7zA:
1.9		 4m11A-4f7zA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmz INTERNALIN

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13855
(LRR_8) 		5 MET A 167
LEU A 145
LEU A 178
LEU A 170
LEU A 139
 None
 1.25A 4m11A-4fmzA:
undetectable		 4m11A-4fmzA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		5 MET A 557
LEU A 703
LEU A 569
LEU A 553
ALA A 594
 None
 1.40A 4m11A-4fwgA:
undetectable		 4m11A-4fwgA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyb COPPER OXIDASE

(Streptomyces
lividans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 MET A  53
LEU A  51
VAL A 103
LEU A 101
LEU A  87
 None
 1.27A 4m11A-4gybA:
undetectable		 4m11A-4gybA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		5 MET A 175
ILE A  74
LEU A 320
LEU A  72
LEU A 130
 None
 1.36A 4m11A-4h59A:
undetectable		 4m11A-4h59A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdu AEROTOLERANCE-RELATE
D MEMBRANE PROTEIN

(Bacteroides
fragilis) 		PF00092
(VWA) 		5 LEU A 118
ILE A  94
LEU A  96
MET A 258
LEU A 223
 None
 1.41A 4m11A-4jduA:
undetectable		 4m11A-4jduA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kem MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azospirillum
lipoferum) 		PF13378
(MR_MLE_C) 		5 LEU A  95
ILE A  67
LEU A 387
LEU A  62
ALA A 117
 None
 1.22A 4m11A-4kemA:
undetectable		 4m11A-4kemA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 ILE A 274
VAL A 298
LEU A 324
LEU A 295
LEU A 288
 None
 1.38A 4m11A-4lxrA:
undetectable		 4m11A-4lxrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 LEU A 993
LEU A 776
TRP A 792
ALA A 800
LEU A 818
 None
 1.13A 4m11A-4n1aA:
undetectable		 4m11A-4n1aA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olq ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Hyphomonas
neptunium) 		PF00378
(ECH_1) 		5 LEU A 116
ILE A   5
ALA A  26
SER A  28
LEU A  27
 None
 1.01A 4m11A-4olqA:
undetectable		 4m11A-4olqA:
19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 MET A 114
ARG A 121
VAL A 350
LEU A 360
ALA A 528
SER A 531
 None
BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
 0.71A 4m11A-4ph9A:
63.5		 4m11A-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 MET A 114
LEU A 118
ARG A 121
ILE A 346
VAL A 350
LEU A 360
TRP A 388
MET A 523
ALA A 528
 None
None
BOG  A 604 ( 3.7A)
None
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
None
None
IBP  A 601 (-3.4A)
 0.53A 4m11A-4ph9A:
63.5		 4m11A-4ph9A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		5 LEU A  66
ILE A 226
ALA A 258
SER A 259
LEU A 260
 None
 1.24A 4m11A-4r5zA:
undetectable		 4m11A-4r5zA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 LEU A 210
ILE A 297
VAL A 293
ALA A 271
LEU A 269
 None
 1.27A 4m11A-4roeA:
undetectable		 4m11A-4roeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 LEU A 210
ILE A 297
VAL A 293
LEU A 300
LEU A 269
 None
 1.20A 4m11A-4roeA:
undetectable		 4m11A-4roeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 ILE A  55
VAL A  57
LEU A  48
MET A 426
ALA A 392
 None
 1.44A 4m11A-4w1wA:
undetectable		 4m11A-4w1wA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wiw GLYCOSIDE HYDROLASE
FAMILY 18

(Desulfitobacterium
hafniense) 		PF00704
(Glyco_hydro_18) 		5 LEU A 479
ILE A 457
VAL A 497
ALA A 523
LEU A 520
 None
 1.20A 4m11A-4wiwA:
0.1		 4m11A-4wiwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x68 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00144
(Beta-lactamase) 		5 LEU A 387
VAL A  56
LEU A 363
ALA A  41
LEU A  37
 None
 1.08A 4m11A-4x68A:
undetectable		 4m11A-4x68A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3j PUTATIVE
QUINONE-OXIDOREDUCTA
SE HOMOLOG,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 MET A 287
LEU A 290
LEU A 139
ALA A 179
LEU A 178
 None
 1.46A 4m11A-5a3jA:
undetectable		 4m11A-5a3jA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwh DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 5 ILE A  67
LEU A  93
LEU A 105
ALA A  57
LEU A  65
 None
 1.38A 4m11A-5cwhA:
undetectable		 4m11A-5cwhA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0n ENOYL-COA
HYDRATASE/ISOMERASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		5 MET X  36
LEU X  39
LEU X 155
LEU X  95
ALA X 125
 None
 1.34A 4m11A-5e0nX:
undetectable		 4m11A-5e0nX:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A1031
ILE A 995
LEU A1095
LEU A 990
ALA A1004
 None
 1.04A 4m11A-5f1zA:
undetectable		 4m11A-5f1zA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG

(Microbacterium
sp.) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		5 LEU A 181
VAL A 113
ALA A 139
SER A 140
LEU A 144
 None
 1.27A 4m11A-5h1aA:
undetectable		 4m11A-5h1aA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL

(Caenorhabditis
elegans) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF16526
(CLZ) 		5 MET A 530
LEU A 590
ILE A 493
VAL A 491
LEU A 505
 None
 1.46A 4m11A-5h3oA:
undetectable		 4m11A-5h3oA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6o PORPHOBILINOGEN
DEAMINASE

(Vibrio cholerae) 		no annotation 5 MET A 240
LEU A 244
LEU A 296
SER A 302
LEU A 301
 None
 1.44A 4m11A-5h6oA:
undetectable		 4m11A-5h6oA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE

(Saccharomyces
cerevisiae) 		PF04752
(ChaC) 		5 MET A 141
LEU A 142
ILE A  28
VAL A  96
LEU A  11
 None
 1.18A 4m11A-5hwiA:
undetectable		 4m11A-5hwiA:
16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 MET A 113
LEU A 117
ARG A 120
ILE A 345
VAL A 349
LEU A 352
LEU A 359
TRP A 387
MET A 522
ALA A 527
SER A 530
 None
None
ID8  A 601 ( 4.4A)
None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-4.2A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.55A 4m11A-5ikrA:
62.4		 4m11A-5ikrA:
88.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5d 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00701
(DHDPS) 		5 MET A 251
LEU A 259
LEU A  15
ALA A 218
LEU A 217
 6GT  A 403 ( 4.4A)
None
None
None
None
 1.26A 4m11A-5j5dA:
undetectable		 4m11A-5j5dA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Paraburkholderia
xenovorans) 		PF00155
(Aminotran_1_2) 		5 LEU A  93
VAL A 246
ALA A 284
SER A 285
LEU A 286
 None
 1.20A 4m11A-5jayA:
undetectable		 4m11A-5jayA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr9 NEQ131

(Nanoarchaeum
equitans) 		PF01997
(Translin) 		5 MET B  29
LEU B  55
VAL B 106
LEU B  80
LEU B  87
 None
 1.44A 4m11A-5jr9B:
undetectable		 4m11A-5jr9B:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvk PROTEIN KP700603

(Klebsiella
pneumoniae) 		PF02464
(CinA) 		5 ILE A 108
LEU A 162
LEU A  41
TRP A 169
ALA A 105
 None
 1.29A 4m11A-5kvkA:
undetectable		 4m11A-5kvkA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 LEU A 673
ILE A 634
LEU A 631
SER A 710
LEU A 711
 None
 0.97A 4m11A-5lmgA:
undetectable		 4m11A-5lmgA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mek CYTOSOLIC
SULFOTRANSFERASE 18

(Arabidopsis
thaliana) 		PF00685
(Sulfotransfer_1) 		5 MET A 261
LEU A 257
VAL A 128
ALA A 101
LEU A  99
 None
 1.49A 4m11A-5mekA:
undetectable		 4m11A-5mekA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5och -

(-) 		no annotation 5 LEU B 612
VAL B 650
LEU B 654
ALA B 621
LEU B 620
 None
 1.31A 4m11A-5ochB:
undetectable		 4m11A-5ochB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 5 LEU A 401
ILE A 371
LEU A 361
ALA A 408
LEU A 405
 None
 1.34A 4m11A-5ot1A:
undetectable		 4m11A-5ot1A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp4 AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Burkholderia
ambifaria) 		PF01546
(Peptidase_M20) 		5 ARG A  93
VAL A  97
LEU A 101
TRP A  49
ALA A  20
 EDO  A 506 (-3.6A)
None
None
None
EDO  A 506 ( 4.9A)
 1.02A 4m11A-5tp4A:
undetectable		 4m11A-5tp4A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		5 LEU A1300
VAL A1481
LEU A1292
ALA A1306
LEU A1304
 None
 1.06A 4m11A-5u89A:
undetectable		 4m11A-5u89A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ILE A 345
VAL A 351
LEU A 342
ALA A 316
LEU A 312
 None
 1.30A 4m11A-5wy4A:
undetectable		 4m11A-5wy4A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 5 LEU A 341
VAL A 507
LEU A 615
LEU A 511
LEU A 445
 None
 1.18A 4m11A-5yfbA:
1.4		 4m11A-5yfbA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
epidermidis) 		no annotation 5 LEU A 337
LEU A 452
ALA A 354
SER A 433
LEU A 355
 None
 1.32A 4m11A-5yjjA:
undetectable		 4m11A-5yjjA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		no annotation 5 LEU A 156
ILE A 204
LEU A 245
LEU A 201
ALA A 121
 None
 1.19A 4m11A-5yksA:
undetectable		 4m11A-5yksA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 MET A 310
LEU A 307
LEU A 320
LEU A 313
ALA A 329
 None
 1.29A 4m11A-5zlnA:
undetectable		 4m11A-5zlnA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6an0 HISTIDINOL
DEHYDROGENASE

(Elizabethkingia
anophelis) 		PF00815
(Histidinol_dh) 		5 MET A   1
LEU A 298
ALA A 250
SER A 254
LEU A 253
 None
 1.50A 4m11A-6an0A:
undetectable		 4m11A-6an0A:
20.99