SIMILAR PATTERNS OF AMINO ACIDS FOR 4LV9_B_20JB602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 VAL A 123
ILE A 153
ILE A 156
ALA A 155
 None
 0.90A 4lv9B-1br2A:
undetectable		 4lv9B-1br2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfr RESTRICTION
ENDONUCLEASE

(Citrobacter
freundii) 		PF07832
(Bse634I) 		4 TYR A 230
ILE A  74
ILE A 269
ALA A 232
 None
 0.85A 4lv9B-1cfrA:
undetectable		 4lv9B-1cfrA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clx XYLANASE A

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10) 		4 TYR A 283
VAL A 216
ILE A 226
ILE A 223
 None
 0.82A 4lv9B-1clxA:
2.9		 4lv9B-1clxA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 ILE A 612
ARG A 611
ILE A 549
ALA A 610
 None
 0.95A 4lv9B-1ex0A:
undetectable		 4lv9B-1ex0A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		4 VAL A 201
ARG A 245
ILE A 143
ALA A 241
 None
 0.89A 4lv9B-1gq2A:
2.7		 4lv9B-1gq2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747

(Methanothermobacter
thermautotrophicus) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		4 VAL A  11
ILE A 112
ILE A 125
ALA A 110
 NAP  A1350 (-3.8A)
NAP  A1350 ( 3.7A)
None
None
 0.82A 4lv9B-1i36A:
undetectable		 4lv9B-1i36A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8t UDP-GALACTOPYRANOSE
MUTASE

(Escherichia
coli) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 ILE A 227
ARG A 226
ILE A   5
ALA A 224
 None
 0.92A 4lv9B-1i8tA:
undetectable		 4lv9B-1i8tA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k19 CHEMOSENSORY PROTEIN
CSP2

(Mamestra
brassicae) 		PF03392
(OS-D) 		4 TYR A  98
ILE A  78
ILE A 107
ALA A 102
 None
 0.87A 4lv9B-1k19A:
undetectable		 4lv9B-1k19A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nar NARBONIN

(Vicia
narbonensis) 		PF00704
(Glyco_hydro_18) 		4 TYR A  35
VAL A  68
ILE A 124
ILE A  82
 None
 0.74A 4lv9B-1narA:
3.2		 4lv9B-1narA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT

(Propionibacterium
freudenreichii) 		PF01039
(Carboxyl_trans) 		4 ILE A 297
ARG A 294
ILE A 331
ALA A 320
 None
 0.81A 4lv9B-1on9A:
2.5		 4lv9B-1on9A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg3 ALLANTOICASE

(Saccharomyces
cerevisiae) 		PF03561
(Allantoicase) 		4 TYR A 119
ILE A  95
ILE A 137
ALA A 117
 None
 0.91A 4lv9B-1sg3A:
undetectable		 4lv9B-1sg3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE

(Thermus
thermophilus) 		PF00697
(PRAI) 		4 VAL A  56
ARG A 148
ILE A 150
ALA A 170
 None
 0.81A 4lv9B-1v5xA:
2.6		 4lv9B-1v5xA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00218
(IGPS) 		4 VAL A 177
ARG A  80
ILE A  49
ALA A  81
 None
SO4  A2002 (-3.8A)
None
None
 0.65A 4lv9B-1vc4A:
3.2		 4lv9B-1vc4A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgj HYPOTHETICAL PROTEIN
PH0099

(Pyrococcus
horikoshii) 		PF02834
(LigT_PEase) 		4 VAL A 157
ARG A 101
ILE A  94
ALA A 124
 None
 0.81A 4lv9B-1vgjA:
undetectable		 4lv9B-1vgjA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfz HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Caldanaerobacter
subterraneus) 		PF00156
(Pribosyltran) 		4 VAL A 100
ARG A  56
ILE A  58
ALA A  57
 None
 0.73A 4lv9B-1yfzA:
undetectable		 4lv9B-1yfzA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		4 VAL A  59
ILE A  88
ILE A  90
ALA A 104
 None
 0.94A 4lv9B-1zlrA:
undetectable		 4lv9B-1zlrA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP7 CORE
PROTEIN)

(Bluetongue
virus) 		no annotation 4 TYR P  40
VAL P  11
ILE P  99
ILE P  35
 None
 0.93A 4lv9B-2btvP:
undetectable		 4lv9B-2btvP:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 HIS A  32
ILE A  14
ILE A  35
ALA A  36
 None
 0.87A 4lv9B-2dg8A:
undetectable		 4lv9B-2dg8A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjv ATP-DEPENDENT RNA
HELICASE DBPA

(Bacillus
subtilis) 		PF00271
(Helicase_C) 		4 VAL A 234
ILE A 220
ILE A 366
ALA A 218
 None
 0.89A 4lv9B-2hjvA:
undetectable		 4lv9B-2hjvA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01842
(ACT) 		4 TYR A 227
VAL A 258
ARG A 300
ALA A 301
 None
ADP  A 820 (-3.7A)
None
None
 0.93A 4lv9B-2j0wA:
undetectable		 4lv9B-2j0wA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j22 FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF00754
(F5_F8_type_C) 		4 VAL A 143
ILE A 129
ARG A 128
ILE A  92
 None
 0.78A 4lv9B-2j22A:
undetectable		 4lv9B-2j22A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jrx UPF0352 PROTEIN YEJL

(Escherichia
coli) 		PF07208
(DUF1414) 		4 ILE A  49
ARG A  54
ILE A  57
ALA A  56
 None
 0.93A 4lv9B-2jrxA:
undetectable		 4lv9B-2jrxA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzx POLY(RC)-BINDING
PROTEIN 2

(Homo sapiens) 		PF00013
(KH_1) 		4 VAL A 159
ILE A  16
ILE A  68
ALA A  71
 None
 0.89A 4lv9B-2jzxA:
undetectable		 4lv9B-2jzxA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5l FEOA

(Ruminiclostridium
thermocellum) 		PF04023
(FeoA) 		4 VAL A  13
ARG A   5
ILE A  70
ALA A  67
 None
 0.93A 4lv9B-2k5lA:
undetectable		 4lv9B-2k5lA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lpb MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 15

(Saccharomyces
cerevisiae) 		no annotation 4 TYR A 220
VAL A 199
ILE A 186
ARG A 185
 None
 0.71A 4lv9B-2lpbA:
undetectable		 4lv9B-2lpbA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 TYR A 700
ILE A 744
ILE A 715
ALA A 704
 None
 0.88A 4lv9B-2qf7A:
2.4		 4lv9B-2qf7A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 VAL B 169
ILE B 184
ARG B 183
ILE B 201
 None
None
SH0  A 503 (-3.8A)
None
 0.92A 4lv9B-2v4jB:
undetectable		 4lv9B-2v4jB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbm RIBOSOME MATURATION
PROTEIN SDO1 HOMOLOG

(Methanothermobacter
thermautotrophicus) 		PF01172
(SBDS)
PF09377
(SBDS_C) 		4 TYR A 180
ILE A 171
ILE A 169
ALA A 202
 None
 0.90A 4lv9B-2wbmA:
undetectable		 4lv9B-2wbmA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x89 ANTIBODY

(Camelus
dromedarius) 		PF07686
(V-set) 		4 VAL A  79
ILE A  51
ARG A  50
ALA A  49
 None
 0.93A 4lv9B-2x89A:
undetectable		 4lv9B-2x89A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT

(Rattus
norvegicus) 		PF01602
(Adaptin_N) 		4 VAL A 390
ILE A 424
ILE A 420
ALA A 416
 None
 0.86A 4lv9B-2xa7A:
undetectable		 4lv9B-2xa7A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 TYR A 247
VAL A 177
ILE A 219
ALA A 223
 None
 0.90A 4lv9B-2yikA:
undetectable		 4lv9B-2yikA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		4 TYR A 503
VAL A 451
ILE A  12
ILE A  10
 None
 0.94A 4lv9B-2yjqA:
2.0		 4lv9B-2yjqA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 TYR A 229
ILE A 180
ILE A 178
ALA A 174
 None
 0.76A 4lv9B-3ciaA:
undetectable		 4lv9B-3ciaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 VAL A 188
ILE A 180
ILE A 178
ALA A 174
 None
 0.70A 4lv9B-3ciaA:
undetectable		 4lv9B-3ciaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE

(Staphylococcus
aureus) 		PF13738
(Pyr_redox_3) 		4 TYR A 129
VAL A 110
ILE A 113
ILE A 134
 SO4  A 371 (-4.7A)
FAD  A 500 ( 3.9A)
None
None
 0.89A 4lv9B-3d1cA:
undetectable		 4lv9B-3d1cA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1

(Thermotoga
maritima) 		PF13507
(GATase_5) 		4 TYR D  42
VAL D   8
ILE D  72
ILE D  82
 None
 0.91A 4lv9B-3d54D:
undetectable		 4lv9B-3d54D:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE

(Corynebacterium
diphtheriae) 		PF12897
(Aminotran_MocR) 		4 HIS A 141
VAL A 214
ILE A 108
ILE A 144
 None
 0.74A 4lv9B-3d6kA:
2.6		 4lv9B-3d6kA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Burkholderia
pseudomallei) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 VAL A 273
ILE A 289
ILE A 263
ALA A 259
 None
 0.79A 4lv9B-3dahA:
undetectable		 4lv9B-3dahA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Staphylococcus
aureus) 		PF13460
(NAD_binding_10) 		4 VAL A  70
ILE A 185
ILE A 182
ALA A  20
 None
 0.88A 4lv9B-3e48A:
undetectable		 4lv9B-3e48A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 TYR A 187
VAL A 183
ILE A 206
ILE A 229
 None
 0.84A 4lv9B-3eluA:
undetectable		 4lv9B-3eluA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f72 CADMIUM EFFLUX
SYSTEM ACCESSORY
PROTEIN

(Staphylococcus
aureus) 		PF01022
(HTH_5) 		4 VAL A  86
ILE A  47
ILE A  62
ALA A  73
 None
 0.85A 4lv9B-3f72A:
undetectable		 4lv9B-3f72A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8d BIOTIN CARBOXYLASE

(Escherichia
coli) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 HIS A  79
ILE A  26
ILE A   5
ALA A  77
 None
 0.78A 4lv9B-3g8dA:
undetectable		 4lv9B-3g8dA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		4 VAL A 216
ILE A 432
ARG A 173
ILE A 434
 None
 0.92A 4lv9B-3h0lA:
undetectable		 4lv9B-3h0lA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 VAL A 123
ILE A 153
ILE A 156
ALA A 155
 None
 0.95A 4lv9B-3j04A:
undetectable		 4lv9B-3j04A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Ehrlichia
chaffeensis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 VAL A 119
ILE A 126
ARG A 127
ILE A 257
 None
None
EDO  A 300 ( 4.5A)
None
 0.90A 4lv9B-3l0gA:
16.3		 4lv9B-3l0gA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A  28
ARG A  20
ILE A 328
ALA A 324
 None
 0.89A 4lv9B-3l8kA:
undetectable		 4lv9B-3l8kA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4v MTA/SAH NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		4 VAL A 146
ILE A 161
ILE A 152
ALA A 199
 None
None
GOL  A 235 (-4.1A)
4CT  A 233 ( 4.1A)
 0.93A 4lv9B-3o4vA:
undetectable		 4lv9B-3o4vA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		4 HIS A 293
ILE A 147
ILE A 296
ALA A 297
 None
 0.92A 4lv9B-3o75A:
undetectable		 4lv9B-3o75A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppl ASPARTATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF12897
(Aminotran_MocR) 		4 HIS A 145
VAL A 218
ILE A 112
ILE A 148
 PLP  A 500 ( 4.9A)
None
None
None
 0.75A 4lv9B-3pplA:
2.7		 4lv9B-3pplA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjp PUTATIVE
UNCHARACTERIZED
PROTEIN PH0350

(Pyrococcus
horikoshii) 		PF01881
(Cas_Cas6) 		4 ILE A  87
ARG A  88
ILE A  90
ALA A  89
 None
 0.82A 4lv9B-3qjpA:
undetectable		 4lv9B-3qjpA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0s ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Campylobacter
jejuni) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 VAL A  64
ILE A  89
ILE A 114
ALA A 112
 None
 0.78A 4lv9B-3r0sA:
undetectable		 4lv9B-3r0sA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 323
HIS A 324
ILE A 120
ILE A 296
 None
 0.81A 4lv9B-3stpA:
2.3		 4lv9B-3stpA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkk PREDICTED
ACETAMIDASE/FORMAMID
ASE

(Caldanaerobacter
subterraneus) 		PF03069
(FmdA_AmdA) 		4 VAL A  32
ILE A  64
ILE A  22
ALA A  21
 None
 0.83A 4lv9B-3tkkA:
undetectable		 4lv9B-3tkkA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toe DNA/RNA-BINDING
PROTEIN ALBA

(Methanothermobacter
thermautotrophicus) 		PF01918
(Alba) 		4 VAL A  32
ILE A  59
ARG A  52
ILE A  56
 None
 0.90A 4lv9B-3toeA:
undetectable		 4lv9B-3toeA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 ILE A 186
ARG A 180
ILE A 178
ALA A 136
 None
 0.83A 4lv9B-3va6A:
undetectable		 4lv9B-3va6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 TYR A4317
VAL A4334
ILE A4310
ILE A4270
 None
 0.87A 4lv9B-3vkgA:
undetectable		 4lv9B-3vkgA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 TYR A 635
VAL A 660
ILE A 505
ARG A 506
 None
 0.93A 4lv9B-3wdjA:
2.6		 4lv9B-3wdjA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE

(Mycolicibacterium
smegmatis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		4 VAL A 153
ARG A 193
ILE A 191
ALA A 101
 None
None
FAD  A 600 (-3.7A)
FAD  A 600 (-3.5A)
 0.91A 4lv9B-4autA:
undetectable		 4lv9B-4autA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5c PUTATIVE OMPA FAMILY
LIPOPROTEIN

(Burkholderia
pseudomallei) 		PF00691
(OmpA) 		4 HIS A  86
ILE A 100
ARG A 125
ILE A  98
 None
 0.87A 4lv9B-4b5cA:
undetectable		 4lv9B-4b5cA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 TYR A  32
VAL A  65
ILE A  35
ILE A  45
 None
 0.91A 4lv9B-4cnsA:
2.3		 4lv9B-4cnsA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dk0 PUTATIVE MACA

(Aggregatibacter
actinomycetemcomitans) 		PF16576
(HlyD_D23) 		4 VAL A 201
ILE A 210
ILE A 182
ALA A  86
 None
 0.89A 4lv9B-4dk0A:
undetectable		 4lv9B-4dk0A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1

(Danio rerio) 		PF00079
(Serpin) 		4 TYR A  32
VAL A  83
ILE A 225
ILE A 354
 None
 0.60A 4lv9B-4dteA:
undetectable		 4lv9B-4dteA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etp KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		4 VAL A 410
ILE A 393
ARG A 392
ILE A 700
 GOL  A 803 (-4.0A)
GOL  A 803 ( 4.4A)
ADP  A 801 (-3.4A)
None
 0.82A 4lv9B-4etpA:
undetectable		 4lv9B-4etpA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1

(Saccharomyces
cerevisiae) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 VAL A 235
ARG A 146
ILE A 148
ALA A 147
 None
 0.88A 4lv9B-4fgwA:
undetectable		 4lv9B-4fgwA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flm S-FORMYLGLUTATHIONE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF00756
(Esterase) 		4 TYR A 165
ILE A 233
ILE A 235
ALA A 185
 None
 0.78A 4lv9B-4flmA:
undetectable		 4lv9B-4flmA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TYR A  37
ILE A 109
ARG A  97
ILE A 100
 TYR  A  37 ( 1.3A)
ILE  A 109 ( 0.6A)
ARG  A  97 ( 0.6A)
ILE  A 100 ( 0.6A)
 0.92A 4lv9B-4flxA:
undetectable		 4lv9B-4flxA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g09 HISTIDINOL
DEHYDROGENASE

(Brucella suis) 		PF00815
(Histidinol_dh) 		5 TYR A 185
VAL A 206
ILE A 209
ILE A 193
ALA A 192
 None
 1.30A 4lv9B-4g09A:
undetectable		 4lv9B-4g09A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkr NECK AND C-TERMINAL
MOTOR DOMAIN OF KAR3

([Candida]
glabrata) 		PF00225
(Kinesin) 		4 VAL A 373
ILE A 357
ARG A 356
ILE A 663
 None
None
ADP  A 702 (-3.3A)
None
 0.77A 4lv9B-4gkrA:
undetectable		 4lv9B-4gkrA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ic7 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 5

(Homo sapiens) 		no annotation 4 VAL E  47
ILE E  21
ARG E  20
ILE E 104
 None
 0.94A 4lv9B-4ic7E:
undetectable		 4lv9B-4ic7E:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE

(Bacillus
megaterium) 		PF00561
(Abhydrolase_1) 		4 HIS A 124
VAL A 254
ILE A 233
ALA A 119
 None
 0.88A 4lv9B-4inzA:
undetectable		 4lv9B-4inzA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN

(Chaetomium
thermophilum) 		PF00557
(Peptidase_M24) 		4 TYR A 119
VAL A 242
ILE A 351
ALA A  24
 None
 0.66A 4lv9B-4ipaA:
undetectable		 4lv9B-4ipaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqn PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF16728
(DUF5066) 		4 TYR C  87
ARG C  35
ILE C 137
ALA C 121
 None
 0.92A 4lv9B-4iqnC:
undetectable		 4lv9B-4iqnC:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx6 PYRUVATE CARBOXYLASE

(Rhizobium etli) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 TYR A 700
ILE A 744
ILE A 715
ALA A 704
 None
 0.86A 4lv9B-4jx6A:
2.2		 4lv9B-4jx6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00156
(Pribosyltran) 		4 VAL A 121
ARG A  77
ILE A  79
ALA A  78
 VAL  A 121 ( 0.6A)
ARG  A  77 ( 0.6A)
ILE  A  79 ( 0.7A)
ALA  A  78 ( 0.0A)
 0.84A 4lv9B-4rhyA:
undetectable		 4lv9B-4rhyA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 VAL A 448
ARG A  58
ILE A  57
ALA A  54
 None
 0.74A 4lv9B-4tweA:
undetectable		 4lv9B-4tweA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcg ORF112

(Cyprinid
herpesvirus 3) 		PF02295
(z-alpha) 		4 VAL A 265
ILE A 226
ILE A 241
ALA A 238
 None
 0.92A 4lv9B-4wcgA:
undetectable		 4lv9B-4wcgA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xac EVDO2

(Micromonospora
carbonacea) 		PF05721
(PhyH) 		4 VAL A 208
ILE A  97
ARG A  93
ILE A  10
 None
 0.83A 4lv9B-4xacA:
undetectable		 4lv9B-4xacA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)

(Candidatus
Korarchaeum
cryptofilum) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		4 TYR A 361
VAL A 411
ILE A 400
ALA A 399
 None
 0.82A 4lv9B-4xz3A:
3.2		 4lv9B-4xz3A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bx1 PROTEIN TYROSINE
PHOSPHATASE TYPE IVA
1

(Homo sapiens) 		PF00782
(DSPc) 		4 TYR A  40
ILE A  63
ILE A  45
ALA A 101
 None
 0.94A 4lv9B-5bx1A:
undetectable		 4lv9B-5bx1A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Thermoproteus
uzoniensis) 		PF01063
(Aminotran_4) 		4 TYR A 238
VAL A 182
ILE A 192
ALA A 240
 None
 0.90A 4lv9B-5ce8A:
undetectable		 4lv9B-5ce8A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Thermoproteus
uzoniensis) 		PF01063
(Aminotran_4) 		4 VAL A 246
ILE A 272
ILE A 219
ALA A 220
 None
 0.89A 4lv9B-5ce8A:
undetectable		 4lv9B-5ce8A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 VAL A 861
ILE A 849
ILE A 838
ALA A 802
 None
 0.94A 4lv9B-5d0fA:
2.5		 4lv9B-5d0fA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epf PEROXIREDOXIN

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 VAL A 128
ARG A 157
ILE A 159
ALA A 158
 None
 0.76A 4lv9B-5epfA:
undetectable		 4lv9B-5epfA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE

(Saccharomyces
cerevisiae) 		PF04752
(ChaC) 		4 TYR A  78
ILE A  65
ILE A  60
ALA A  36
 None
 0.78A 4lv9B-5hwiA:
undetectable		 4lv9B-5hwiA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd9 SPORE COAT PROTEIN H

(Bacillus cereus) 		PF08757
(CotH) 		4 TYR A 196
VAL A 206
ARG A 284
ILE A 282
 None
 0.88A 4lv9B-5jd9A:
undetectable		 4lv9B-5jd9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00535
(Glycos_transf_2) 		4 ILE A  89
ARG A  90
ILE A  92
ALA A  91
 None
 0.86A 4lv9B-5jqxA:
undetectable		 4lv9B-5jqxA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA

(Methylobacillus
flagellatus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 HIS A  78
ILE A  26
ILE A   5
ALA A  76
 None
 0.89A 4lv9B-5ks8A:
undetectable		 4lv9B-5ks8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Sinorhizobium
meliloti) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		4 VAL A  97
ILE A 105
ARG A  33
ILE A  32
 None
 0.92A 4lv9B-5l0zA:
undetectable		 4lv9B-5l0zA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m72 SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP72

(Homo sapiens) 		PF17004
(SRP_TPR_like) 		4 TYR A  86
ARG A  93
ILE A  94
ALA A  97
 None
 0.70A 4lv9B-5m72A:
undetectable		 4lv9B-5m72A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG

(Homo sapiens) 		no annotation 4 VAL A 300
ILE A 367
ILE A 344
ALA A 365
 None
 0.90A 4lv9B-5mr7A:
undetectable		 4lv9B-5mr7A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 VAL A 460
ILE A 441
ARG A 352
ILE A 433
 None
 0.90A 4lv9B-5n4lA:
undetectable		 4lv9B-5n4lA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nri D-ALANINE--D-ALANINE
LIGASE

(Burkholderia
pseudomallei) 		no annotation 4 TYR A 130
VAL A 181
ILE A 137
ALA A 134
 None
 0.94A 4lv9B-5nriA:
undetectable		 4lv9B-5nriA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5op0 DNA POLYMERASE LIGD,
POLYMERASE DOMAIN

(Mycolicibacterium
smegmatis) 		no annotation 4 VAL B  45
ILE B 110
ILE B 111
ALA B 114
 None
 0.93A 4lv9B-5op0B:
undetectable		 4lv9B-5op0B:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		PF04095
(NAPRTase) 		7 TYR A 188
HIS A 191
VAL A 242
ILE A 309
ARG A 349
ILE A 351
ALA A 379
 None
7TA  A 504 (-3.6A)
7TA  A 504 (-4.3A)
7TA  A 504 (-4.4A)
None
7TA  A 504 (-4.1A)
7TA  A 504 (-3.7A)
 0.21A 4lv9B-5u2nA:
58.1		 4lv9B-5u2nA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqd DUMPY: SHORTER THAN
WILD-TYPE

(Caenorhabditis
elegans) 		no annotation 4 TYR A1574
ILE A1250
ILE A1290
ALA A1289
 None
 0.78A 4lv9B-5uqdA:
undetectable		 4lv9B-5uqdA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwy THIOREDOXIN
REDUCTASE

(Streptococcus
pyogenes) 		PF07992
(Pyr_redox_2) 		4 VAL A  91
ILE A  30
ILE A  75
ALA A  28
 None
 0.92A 4lv9B-5uwyA:
undetectable		 4lv9B-5uwyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0x TIP41-LIKE PROTEIN

(Mus musculus) 		no annotation 4 VAL A 227
ILE A 238
ARG A 217
ILE A 194
 None
 0.93A 4lv9B-5w0xA:
undetectable		 4lv9B-5w0xA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y63 ALKYL HYDROPEROXIDE
REDUCTASE, C SUBUNIT

(Enterococcus
faecalis) 		no annotation 4 HIS A  79
ILE A  92
ILE A  89
ALA A  83
 None
 0.85A 4lv9B-5y63A:
undetectable		 4lv9B-5y63A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9h SAFD,PUTATIVE OUTER
MEMBRANE
PROTEIN,PUTATIVE
OUTER MEMBRANE
PROTEIN,PUTATIVE
OUTER MEMBRANE
PROTEIN

(Salmonella
enterica) 		no annotation 4 VAL A 227
ILE A 314
ILE A 195
ALA A 196
 None
 0.75A 4lv9B-5y9hA:
undetectable		 4lv9B-5y9hA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN

(Escherichia
coli) 		no annotation 4 VAL L 536
ILE L   5
ARG L   4
ILE L  23
 None
 0.95A 4lv9B-6ehsL:
undetectable		 4lv9B-6ehsL:
10.37