SIMILAR PATTERNS OF AMINO ACIDS FOR 4LV9_A_20JA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqb PROTEIN (AUREOLYSIN)

(Staphylococcus
aureus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 VAL A 291
ILE A 253
ARG A 256
ALA A 257
 None
 0.85A 4lv9A-1bqbA:
undetectable		 4lv9A-1bqbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 VAL A 123
ILE A 153
ILE A 156
ALA A 155
 None
 0.88A 4lv9A-1br2A:
undetectable		 4lv9A-1br2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfr RESTRICTION
ENDONUCLEASE

(Citrobacter
freundii) 		PF07832
(Bse634I) 		4 TYR A 230
ILE A  74
ILE A 269
ALA A 232
 None
 0.87A 4lv9A-1cfrA:
undetectable		 4lv9A-1cfrA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clx XYLANASE A

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10) 		4 TYR A 283
VAL A 216
ILE A 226
ILE A 223
 None
 0.80A 4lv9A-1clxA:
2.7		 4lv9A-1clxA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE

(Bacillus
subtilis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 VAL A 274
ILE A 286
ILE A 264
ALA A 260
 None
 0.70A 4lv9A-1dkrA:
undetectable		 4lv9A-1dkrA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		4 TYR A 288
ILE A 294
ARG A 295
ILE A 293
 None
 0.87A 4lv9A-1f3lA:
undetectable		 4lv9A-1f3lA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis aries) 		PF00089
(Trypsin) 		4 HIS A  91
ARG A  60
ILE A  90
ALA A  56
 None
 0.85A 4lv9A-1fiwA:
undetectable		 4lv9A-1fiwA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		4 VAL A 201
ARG A 245
ILE A 143
ALA A 241
 None
 0.87A 4lv9A-1gq2A:
undetectable		 4lv9A-1gq2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747

(Methanothermobacter
thermautotrophicus) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		4 VAL A  11
ILE A 112
ILE A 125
ALA A 110
 NAP  A1350 (-3.8A)
NAP  A1350 ( 3.7A)
None
None
 0.81A 4lv9A-1i36A:
undetectable		 4lv9A-1i36A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k19 CHEMOSENSORY PROTEIN
CSP2

(Mamestra
brassicae) 		PF03392
(OS-D) 		4 TYR A  98
ILE A  78
ILE A 107
ALA A 102
 None
 0.87A 4lv9A-1k19A:
undetectable		 4lv9A-1k19A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1b B-CELL LYMPHOMA
3-ENCODED PROTEIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 HIS A 290
VAL A 250
ILE A 260
ALA A 292
 None
 0.87A 4lv9A-1k1bA:
undetectable		 4lv9A-1k1bA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n27 HEPATOMA-DERIVED
GROWTH FACTOR,
RELATED PROTEIN 3

(Mus musculus) 		PF00855
(PWWP) 		5 TYR A  65
ILE A  29
ARG A  28
ILE A  46
ALA A  27
 None
 1.45A 4lv9A-1n27A:
undetectable		 4lv9A-1n27A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nar NARBONIN

(Vicia
narbonensis) 		PF00704
(Glyco_hydro_18) 		4 TYR A  35
VAL A  68
ILE A 124
ILE A  82
 None
 0.74A 4lv9A-1narA:
2.3		 4lv9A-1narA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT

(Propionibacterium
freudenreichii) 		PF01039
(Carboxyl_trans) 		4 ILE A 297
ARG A 294
ILE A 331
ALA A 320
 None
 0.81A 4lv9A-1on9A:
undetectable		 4lv9A-1on9A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ppy ASPARTATE
1-DECARBOXYLASE
PRECURSOR

(Escherichia
coli) 		PF02261
(Asp_decarbox) 		4 TYR A  58
VAL A  71
ILE A  46
ILE A  87
 None
 0.83A 4lv9A-1ppyA:
undetectable		 4lv9A-1ppyA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 TYR A  87
VAL A  69
ILE A  79
ILE A 108
ALA A 107
 None
 1.09A 4lv9A-1qorA:
undetectable		 4lv9A-1qorA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		4 VAL A 670
ILE A 655
ILE A 650
ALA A 603
 None
 0.83A 4lv9A-1ru3A:
undetectable		 4lv9A-1ru3A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg3 ALLANTOICASE

(Saccharomyces
cerevisiae) 		PF03561
(Allantoicase) 		5 VAL A 279
ILE A 338
ARG A 339
ILE A 250
ALA A 199
 None
 1.29A 4lv9A-1sg3A:
undetectable		 4lv9A-1sg3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE

(Thermus
thermophilus) 		PF00697
(PRAI) 		4 VAL A  56
ARG A 148
ILE A 150
ALA A 170
 None
 0.79A 4lv9A-1v5xA:
2.4		 4lv9A-1v5xA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00218
(IGPS) 		4 VAL A 177
ARG A  80
ILE A  49
ALA A  81
 None
SO4  A2002 (-3.8A)
None
None
 0.66A 4lv9A-1vc4A:
3.3		 4lv9A-1vc4A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcw PROTEASE DEGS

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 TYR A  62
VAL A  59
ILE A  91
ILE A 132
ALA A 116
 None
 1.23A 4lv9A-1vcwA:
undetectable		 4lv9A-1vcwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgj HYPOTHETICAL PROTEIN
PH0099

(Pyrococcus
horikoshii) 		PF02834
(LigT_PEase) 		4 VAL A 157
ARG A 101
ILE A  94
ALA A 124
 None
 0.83A 4lv9A-1vgjA:
undetectable		 4lv9A-1vgjA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE

(Streptococcus
pneumoniae) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 VAL A 302
ILE A 270
ILE A 273
ALA A 263
 None
 0.83A 4lv9A-1vqzA:
undetectable		 4lv9A-1vqzA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 TYR B 146
VAL B 259
ILE B 140
ARG B 144
ALA B 205
 None
 1.36A 4lv9A-1wytB:
undetectable		 4lv9A-1wytB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 TYR A 515
VAL A 487
ILE A 463
ILE A 480
ALA A 517
 None
 1.39A 4lv9A-1xfdA:
undetectable		 4lv9A-1xfdA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi9 PUTATIVE
TRANSAMINASE

(Pyrococcus
furiosus) 		PF00155
(Aminotran_1_2) 		4 TYR A 127
VAL A 102
ILE A 203
ALA A 171
 PLP  A 501 (-3.8A)
PLP  A 501 (-3.7A)
None
None
 0.86A 4lv9A-1xi9A:
undetectable		 4lv9A-1xi9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfz HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Caldanaerobacter
subterraneus) 		PF00156
(Pribosyltran) 		4 VAL A 100
ARG A  56
ILE A  58
ALA A  57
 None
 0.72A 4lv9A-1yfzA:
undetectable		 4lv9A-1yfzA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 TYR A 198
ILE A 207
ILE A 177
ALA A 182
 None
 0.88A 4lv9A-1yx2A:
undetectable		 4lv9A-1yx2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5y YKUV PROTEIN

(Bacillus
subtilis) 		PF00578
(AhpC-TSA) 		4 HIS A  68
ILE A  90
ILE A  94
ALA A  66
 None
 0.83A 4lv9A-2b5yA:
undetectable		 4lv9A-2b5yA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		4 TYR A 485
ILE A 498
ILE A 509
ALA A 496
 SIA  A1692 (-4.7A)
None
None
None
 0.87A 4lv9A-2bf6A:
undetectable		 4lv9A-2bf6A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bri URIDYLATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		4 VAL A 201
ILE A 223
ILE A 192
ALA A 189
 None
 0.82A 4lv9A-2briA:
undetectable		 4lv9A-2briA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 HIS A  32
ILE A  14
ILE A  35
ALA A  36
 None
 0.89A 4lv9A-2dg8A:
undetectable		 4lv9A-2dg8A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djw PROBABLE
TRANSCRIPTIONAL
REGULATOR, ASNC
FAMILY

(Thermus
thermophilus) 		PF01037
(AsnC_trans_reg) 		5 TYR A  38
VAL A  66
ILE A  60
ILE A  22
ALA A  42
 None
 1.28A 4lv9A-2djwA:
undetectable		 4lv9A-2djwA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF01230
(HIT) 		4 TYR A 125
ILE A 132
ARG A 133
ILE A 131
 None
 0.86A 4lv9A-2eo4A:
undetectable		 4lv9A-2eo4A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq1 ISOCHORISMATASE

(Escherichia
coli) 		PF00550
(PP-binding)
PF00857
(Isochorismatase) 		4 VAL A 108
ILE A  35
ILE A  60
ALA A  61
 None
 0.89A 4lv9A-2fq1A:
undetectable		 4lv9A-2fq1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 VAL A 561
ILE A 671
ILE A 416
ALA A 423
 None
 0.88A 4lv9A-2fuqA:
undetectable		 4lv9A-2fuqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 VAL A 747
ILE A 772
ARG A 771
ILE A 785
ALA A 770
 None
 1.49A 4lv9A-2gahA:
undetectable		 4lv9A-2gahA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk3 DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Staphylococcus
aureus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 TYR A 111
ILE A 146
ILE A 323
ALA A   9
 None
 0.88A 4lv9A-2hk3A:
undetectable		 4lv9A-2hk3A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 TYR A 857
ILE A 887
ILE A 866
ALA A 861
 None
 0.87A 4lv9A-2hpiA:
undetectable		 4lv9A-2hpiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j22 FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF00754
(F5_F8_type_C) 		4 VAL A 143
ILE A 129
ARG A 128
ILE A  92
 None
 0.77A 4lv9A-2j22A:
undetectable		 4lv9A-2j22A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lpb MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 15

(Saccharomyces
cerevisiae) 		no annotation 4 TYR A 220
VAL A 199
ILE A 186
ARG A 185
 None
 0.68A 4lv9A-2lpbA:
undetectable		 4lv9A-2lpbA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5z TYPE VI SECRETION
SYSTEM COMPONENT

(Escherichia
coli) 		PF05954
(Phage_GPD) 		4 VAL X 228
ILE X 326
ILE X 343
ALA X 362
 None
 0.80A 4lv9A-2p5zX:
undetectable		 4lv9A-2p5zX:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph7 UNCHARACTERIZED
PROTEIN AF_2093

(Archaeoglobus
fulgidus) 		no annotation 4 TYR A 139
ARG A 130
ILE A 170
ALA A 141
 None
 0.87A 4lv9A-2ph7A:
undetectable		 4lv9A-2ph7A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9t DING

(Pseudomonas
fluorescens) 		PF12849
(PBP_like_2) 		4 VAL A 116
ILE A 204
ILE A  96
ALA A 226
 None
 0.81A 4lv9A-2q9tA:
undetectable		 4lv9A-2q9tA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 TYR A 700
ILE A 744
ILE A 715
ALA A 704
 None
 0.89A 4lv9A-2qf7A:
2.4		 4lv9A-2qf7A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3u PROTEASE DEGS

(Escherichia
coli) 		PF13365
(Trypsin_2) 		5 TYR A  62
VAL A  59
ILE A  91
ILE A 132
ALA A 116
 None
 1.19A 4lv9A-2r3uA:
undetectable		 4lv9A-2r3uA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9z GLUTATHIONE AMIDE
REDUCTASE

(Marichromatium
gracile) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A  52
ILE A  91
ILE A  94
ALA A  93
 None
 0.87A 4lv9A-2r9zA:
undetectable		 4lv9A-2r9zA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ucz UBIQUITIN
CONJUGATING ENZYME

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 VAL A 123
ILE A  41
ILE A  24
ALA A  26
 None
 0.88A 4lv9A-2uczA:
undetectable		 4lv9A-2uczA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 VAL B 169
ILE B 184
ARG B 183
ILE B 201
 None
None
SH0  A 503 (-3.8A)
None
 0.88A 4lv9A-2v4jB:
undetectable		 4lv9A-2v4jB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzm ALDO-KETO REDUCTASE

(Mycolicibacterium
smegmatis) 		PF00248
(Aldo_ket_red) 		5 VAL A  64
ILE A  52
ARG A  50
ILE A  27
ALA A  44
 None
 1.33A 4lv9A-2wzmA:
2.9		 4lv9A-2wzmA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1c ACYL-COENZYME

(Penicillium
chrysogenum) 		PF03417
(AAT) 		5 HIS A  17
ILE A  69
ARG A  70
ILE A  83
ALA A  73
 None
 1.42A 4lv9A-2x1cA:
undetectable		 4lv9A-2x1cA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT

(Rattus
norvegicus) 		PF01602
(Adaptin_N) 		4 VAL A 390
ILE A 424
ILE A 420
ALA A 416
 None
 0.87A 4lv9A-2xa7A:
undetectable		 4lv9A-2xa7A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 VAL A 227
ILE A 180
ILE A 157
ALA A  16
 None
 0.73A 4lv9A-2xdfA:
4.8		 4lv9A-2xdfA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtq COLICIN-M

(Escherichia
coli) 		PF14859
(Colicin_M) 		5 TYR A 136
HIS A 235
ILE A 257
ARG A 144
ALA A 132
 None
 1.23A 4lv9A-2xtqA:
undetectable		 4lv9A-2xtqA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN

(Salmonella
enterica) 		PF01297
(ZnuA) 		4 TYR A 296
ILE A 162
ILE A  42
ALA A  41
 None
 0.86A 4lv9A-2xy4A:
undetectable		 4lv9A-2xy4A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b02 TRANSCRIPTIONAL
REGULATOR, CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 HIS A 142
ILE A 116
ILE A 145
ALA A 146
 None
 0.80A 4lv9A-3b02A:
undetectable		 4lv9A-3b02A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce1 SUPEROXIDE DISMUTASE
[CU-ZN]

(Naganishia
liquefaciens) 		PF00080
(Sod_Cu) 		4 ILE A 123
ARG A  47
ILE A  38
ALA A  99
 None
 0.83A 4lv9A-3ce1A:
undetectable		 4lv9A-3ce1A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 TYR A 229
ILE A 180
ILE A 178
ALA A 174
 None
 0.75A 4lv9A-3ciaA:
undetectable		 4lv9A-3ciaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 VAL A 188
ILE A 180
ILE A 178
ALA A 174
 None
 0.66A 4lv9A-3ciaA:
undetectable		 4lv9A-3ciaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqg NUCLEAR PORE COMPLEX
PROTEIN NUP107

(Homo sapiens) 		PF04121
(Nup84_Nup100) 		4 HIS A 747
ILE A 723
ILE A 744
ALA A 743
 None
 0.87A 4lv9A-3cqgA:
undetectable		 4lv9A-3cqgA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE

(Staphylococcus
aureus) 		PF13738
(Pyr_redox_3) 		4 TYR A 129
VAL A 110
ILE A 113
ILE A 134
 SO4  A 371 (-4.7A)
FAD  A 500 ( 3.9A)
None
None
 0.88A 4lv9A-3d1cA:
undetectable		 4lv9A-3d1cA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1

(Thermotoga
maritima) 		PF13507
(GATase_5) 		4 TYR D  42
VAL D   8
ILE D  72
ILE D  82
 None
 0.89A 4lv9A-3d54D:
undetectable		 4lv9A-3d54D:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE

(Corynebacterium
diphtheriae) 		PF12897
(Aminotran_MocR) 		4 HIS A 141
VAL A 214
ILE A 108
ILE A 144
 None
 0.77A 4lv9A-3d6kA:
undetectable		 4lv9A-3d6kA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Burkholderia
pseudomallei) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 VAL A 273
ILE A 289
ILE A 263
ALA A 259
 None
 0.77A 4lv9A-3dahA:
undetectable		 4lv9A-3dahA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Staphylococcus
aureus) 		PF13460
(NAD_binding_10) 		4 VAL A  70
ILE A 185
ILE A 182
ALA A  20
 None
 0.86A 4lv9A-3e48A:
undetectable		 4lv9A-3e48A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA) 		4 TYR A   6
VAL A  19
ILE A  50
ILE A  33
 None
 0.79A 4lv9A-3e9mA:
undetectable		 4lv9A-3e9mA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		5 TYR A 803
VAL A 824
ILE A 826
ILE A 811
ALA A 809
 None
 1.48A 4lv9A-3egiA:
undetectable		 4lv9A-3egiA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 TYR A 187
VAL A 183
ILE A 206
ILE A 229
 None
 0.80A 4lv9A-3eluA:
undetectable		 4lv9A-3eluA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eza PHOSPHOTRANSFERASE
SYSTEM, ENZYME I

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF05524
(PEP-utilisers_N) 		4 VAL A 227
ILE A 180
ILE A 157
ALA A  16
 None
 0.80A 4lv9A-3ezaA:
undetectable		 4lv9A-3ezaA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f72 CADMIUM EFFLUX
SYSTEM ACCESSORY
PROTEIN

(Staphylococcus
aureus) 		PF01022
(HTH_5) 		4 VAL A  86
ILE A  47
ILE A  62
ALA A  73
 None
 0.82A 4lv9A-3f72A:
undetectable		 4lv9A-3f72A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fes ATP-DEPENDENT CLP
ENDOPEPTIDASE

(Clostridioides
difficile) 		PF02861
(Clp_N) 		4 ILE A  86
ARG A  82
ILE A 111
ALA A 119
 None
 0.88A 4lv9A-3fesA:
undetectable		 4lv9A-3fesA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		4 TYR A 158
VAL A 143
ILE A  95
ILE A   3
 None
 0.88A 4lv9A-3fv3A:
undetectable		 4lv9A-3fv3A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8d BIOTIN CARBOXYLASE

(Escherichia
coli) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 HIS A  79
ILE A  26
ILE A   5
ALA A  77
 None
 0.78A 4lv9A-3g8dA:
undetectable		 4lv9A-3g8dA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwf CYCLOHEXANONE
MONOOXYGENASE

(Rhodococcus sp.
HI-31) 		PF00743
(FMO-like) 		4 VAL A 143
ILE A 392
ILE A 394
ALA A 115
 FAD  A 541 (-3.8A)
FAD  A 541 (-4.5A)
None
None
 0.78A 4lv9A-3gwfA:
undetectable		 4lv9A-3gwfA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 VAL A1287
ILE A1328
ILE A1384
ALA A1222
 None
 0.86A 4lv9A-3hmjA:
undetectable		 4lv9A-3hmjA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf8 PROTEIN TEN1

(Candida
tropicalis) 		PF12658
(Ten1) 		4 TYR B  86
ILE B  60
ILE B  82
ALA B  84
 None
 0.86A 4lv9A-3kf8B:
undetectable		 4lv9A-3kf8B:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Thermoanaerobacter
pseudethanolicus) 		PF00724
(Oxidored_FMN) 		4 TYR A 235
VAL A 217
ILE A 272
ARG A 275
 None
 0.87A 4lv9A-3krzA:
2.1		 4lv9A-3krzA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwe CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN

(Thermosynechococcus
elongatus) 		PF00132
(Hexapep) 		4 VAL A 135
ILE A 146
ARG A 128
ALA A 127
 None
 0.85A 4lv9A-3kweA:
undetectable		 4lv9A-3kweA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Ehrlichia
chaffeensis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 VAL A 119
ILE A 126
ARG A 127
ILE A 257
 None
None
EDO  A 300 ( 4.5A)
None
 0.86A 4lv9A-3l0gA:
16.0		 4lv9A-3l0gA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE

(Methanocaldococcus
jannaschii) 		PF02277
(DBI_PRT) 		4 VAL A 328
ILE A  15
ILE A 235
ALA A 263
 None
 0.81A 4lv9A-3l0zA:
2.5		 4lv9A-3l0zA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A  28
ARG A  20
ILE A 328
ALA A 324
 None
 0.89A 4lv9A-3l8kA:
undetectable		 4lv9A-3l8kA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgi PROTEASE DEGS

(Escherichia
coli) 		PF13365
(Trypsin_2) 		5 TYR A  62
VAL A  59
ILE A  91
ILE A 132
ALA A 116
 None
 1.19A 4lv9A-3lgiA:
undetectable		 4lv9A-3lgiA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		5 TYR X 486
VAL X 367
ARG X 493
ILE X 495
ALA X 494
 None
 1.17A 4lv9A-3lxuX:
undetectable		 4lv9A-3lxuX:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mf9 ENDO-1,4-BETA-XYLANA
SE

(Thermopolyspora
flexuosa) 		PF00457
(Glyco_hydro_11) 		4 TYR A  79
ILE A 152
ARG A  60
ILE A 150
 None
 0.87A 4lv9A-3mf9A:
undetectable		 4lv9A-3mf9A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4v MTA/SAH NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		4 VAL A 146
ILE A 161
ILE A 152
ALA A 199
 None
None
GOL  A 235 (-4.1A)
4CT  A 233 ( 4.1A)
 0.89A 4lv9A-3o4vA:
undetectable		 4lv9A-3o4vA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouu BIOTIN CARBOXYLASE

(Campylobacter
jejuni) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 TYR A 372
VAL A 377
ILE A 385
ILE A 411
 None
 0.88A 4lv9A-3ouuA:
undetectable		 4lv9A-3ouuA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppl ASPARTATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF12897
(Aminotran_MocR) 		4 HIS A 145
VAL A 218
ILE A 112
ILE A 148
 PLP  A 500 ( 4.9A)
None
None
None
 0.77A 4lv9A-3pplA:
2.1		 4lv9A-3pplA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjp PUTATIVE
UNCHARACTERIZED
PROTEIN PH0350

(Pyrococcus
horikoshii) 		PF01881
(Cas_Cas6) 		4 ILE A  87
ARG A  88
ILE A  90
ALA A  89
 None
 0.81A 4lv9A-3qjpA:
undetectable		 4lv9A-3qjpA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 VAL A 719
ILE A 721
ILE A 748
ALA A 765
 None
 0.82A 4lv9A-3qr1A:
3.4		 4lv9A-3qr1A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0s ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Campylobacter
jejuni) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 VAL A  64
ILE A  89
ILE A 114
ALA A 112
 None
 0.74A 4lv9A-3r0sA:
undetectable		 4lv9A-3r0sA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Legionella
pneumophila) 		PF00478
(IMPDH) 		5 TYR A 157
VAL A 149
ILE A 166
ARG A 200
ALA A 163
 None
 1.41A 4lv9A-3r2gA:
2.6		 4lv9A-3r2gA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 TYR C 817
VAL C 782
ILE C 787
ALA C 813
 None
 0.84A 4lv9A-3sr6C:
undetectable		 4lv9A-3sr6C:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 323
HIS A 324
ILE A 120
ILE A 296
 None
 0.80A 4lv9A-3stpA:
2.6		 4lv9A-3stpA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 ILE A 247
ARG A 245
ILE A 190
ALA A 185
 None
 0.89A 4lv9A-3sutA:
4.6		 4lv9A-3sutA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkk PREDICTED
ACETAMIDASE/FORMAMID
ASE

(Caldanaerobacter
subterraneus) 		PF03069
(FmdA_AmdA) 		4 VAL A  32
ILE A  64
ILE A  22
ALA A  21
 None
 0.85A 4lv9A-3tkkA:
undetectable		 4lv9A-3tkkA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufk UNDA

(Shewanella sp.
HRCR_06) 		PF13435
(Cytochrome_C554) 		4 VAL A  60
ILE A 207
ARG A 206
ILE A  97
 None
 0.87A 4lv9A-3ufkA:
undetectable		 4lv9A-3ufkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 ILE A 186
ARG A 180
ILE A 178
ALA A 136
 None
 0.84A 4lv9A-3va6A:
undetectable		 4lv9A-3va6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 TYR A4317
VAL A4334
ILE A4310
ILE A4270
 None
 0.84A 4lv9A-3vkgA:
undetectable		 4lv9A-3vkgA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9v PHOSPHATE-BINDING
PROTEIN

(unidentified
prokaryotic
organism) 		PF12849
(PBP_like_2) 		4 VAL A 115
ILE A 208
ILE A  95
ALA A 230
 None
 0.79A 4lv9A-3w9vA:
undetectable		 4lv9A-3w9vA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcq FERREDOXIN

(Cyanidioschyzon
merolae) 		PF00111
(Fer2) 		4 TYR A  24
VAL A  57
ILE A  88
ILE A   4
 None
 0.84A 4lv9A-3wcqA:
undetectable		 4lv9A-3wcqA:
11.97