SIMILAR PATTERNS OF AMINO ACIDS FOR 4LUH_A_ACTA610

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Methanothermus
fervidus) 		no annotation 3 VAL P 138
SER P 139
THR P 142
 None
SO4  P1001 (-2.7A)
None
 0.48A 4luhA-1cf2P:
0.4		 4luhA-1cf2P:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqc LAC REPRESSOR

(Escherichia
coli) 		PF00356
(LacI) 		3 VAL A  30
SER A  31
THR A  34
 None
 0.47A 4luhA-1lqcA:
undetectable		 4luhA-1lqcA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mje BREAST CANCER 2

(Mus musculus) 		PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical) 		3 VAL A2959
SER A2960
THR A2963
 None
 0.44A 4luhA-1mjeA:
0.0		 4luhA-1mjeA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzn FISSION PROTEIN
FIS1P

(Homo sapiens) 		PF14852
(Fis1_TPR_N)
PF14853
(Fis1_TPR_C) 		3 VAL A  33
SER A  34
THR A  37
 None
 0.30A 4luhA-1nznA:
3.9		 4luhA-1nznA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc2 MITOCHONDRIA FISSION
PROTEIN

(Homo sapiens) 		PF14852
(Fis1_TPR_N)
PF14853
(Fis1_TPR_C) 		3 VAL A  30
SER A  31
THR A  34
 None
 0.30A 4luhA-1pc2A:
2.8		 4luhA-1pc2A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pq5 TRYPSIN

(Fusarium
oxysporum) 		PF00089
(Trypsin) 		3 VAL A 160
SER A 161
THR A 164
 None
 0.23A 4luhA-1pq5A:
undetectable		 4luhA-1pq5A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5q PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		3 VAL H 205
SER H 206
THR H 209
 None
 0.24A 4luhA-1q5qH:
2.6		 4luhA-1q5qH:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5r PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		3 VAL H 205
SER H 206
THR H 209
 None
 0.28A 4luhA-1q5rH:
undetectable		 4luhA-1q5rH:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgw PROTEIN
(CRYPTOPHYTAN
PHYCOERYTHRIN
(ALPHA-2 CHAIN))

(Rhodomonas sp.
CS24) 		PF02972
(Phycoerythr_ab) 		3 VAL B  49
SER B  50
THR B  53
 None
 0.37A 4luhA-1qgwB:
undetectable		 4luhA-1qgwB:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s29 LA PROTEIN

(Trypanosoma
brucei) 		PF05383
(La) 		3 VAL A  45
SER A  46
THR A  49
 None
 0.29A 4luhA-1s29A:
undetectable		 4luhA-1s29A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3h DEPHOSPHO-COA KINASE

(Escherichia
coli) 		PF01121
(CoaE) 		3 VAL A 132
SER A 133
THR A 136
 None
 0.43A 4luhA-1t3hA:
undetectable		 4luhA-1t3hA:
15.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		3 VAL A 418
SER A 419
THR A 422
 None
 0.20A 4luhA-1tf0A:
45.0		 4luhA-1tf0A:
75.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		3 VAL B 346
SER B 347
THR B 350
 None
 0.44A 4luhA-1tnuB:
undetectable		 4luhA-1tnuB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txo PUTATIVE BACTERIAL
ENZYME

(Mycobacterium
tuberculosis) 		PF13672
(PP2C_2) 		3 VAL A 197
SER A 198
THR A 201
 None
 0.33A 4luhA-1txoA:
undetectable		 4luhA-1txoA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upi DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Mycobacterium
tuberculosis) 		PF00908
(dTDP_sugar_isom) 		3 VAL A  77
SER A  78
THR A 129
 None
 0.47A 4luhA-1upiA:
undetectable		 4luhA-1upiA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whs SERINE
CARBOXYPEPTIDASE II

(Triticum
aestivum) 		PF00450
(Peptidase_S10) 		3 VAL A 198
SER A 199
THR A 202
 None
 0.47A 4luhA-1whsA:
undetectable		 4luhA-1whsA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1x LEISHMANIA MAJOR
HOMOLOG OF
PROGRAMMED CELL
DEATH 6 PROTEIN

(Leishmania
major) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		3 VAL A 126
SER A 127
THR A 130
 None
 0.44A 4luhA-1y1xA:
undetectable		 4luhA-1y1xA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		3 VAL A 176
SER A 177
THR A 180
 None
 0.48A 4luhA-2a5hA:
undetectable		 4luhA-2a5hA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3n GLUTATHIONE
S-TRANSFERASE THETA
1

(Homo sapiens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 VAL A 128
SER A 129
THR A 132
 None
 0.28A 4luhA-2c3nA:
undetectable		 4luhA-2c3nA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII

(Thermococcus
kodakarensis) 		PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		3 VAL A 468
SER A 469
THR A 472
 None
 0.40A 4luhA-2cw7A:
undetectable		 4luhA-2cw7A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		3 VAL A 139
SER A 140
THR A 143
 None
PO4  A 601 (-2.5A)
None
 0.47A 4luhA-2czcA:
undetectable		 4luhA-2czcA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF13411
(MerR_1) 		3 VAL A  12
SER A  13
THR A  16
 None
 0.24A 4luhA-2dg6A:
undetectable		 4luhA-2dg6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfg BH2851

(Bacillus
halodurans) 		PF01928
(CYTH) 		3 VAL A  13
SER A  14
THR A  17
 None
 0.46A 4luhA-2gfgA:
undetectable		 4luhA-2gfgA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR

(Rhodococcus
jostii) 		PF00392
(GntR)
PF07729
(FCD) 		3 VAL A  61
SER A  62
THR A  65
 None
 0.48A 4luhA-2hs5A:
4.5		 4luhA-2hs5A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN

(Mus musculus) 		PF00617
(RasGEF) 		3 VAL S1140
SER S1141
THR S1144
 None
 0.25A 4luhA-2ijeS:
undetectable		 4luhA-2ijeS:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivx CYCLIN-T2

(Homo sapiens) 		PF00134
(Cyclin_N) 		3 VAL A  53
SER A  54
THR A  57
 None
 0.47A 4luhA-2ivxA:
2.5		 4luhA-2ivxA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixc DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
RMLC

(Mycobacterium
tuberculosis) 		PF00908
(dTDP_sugar_isom) 		3 VAL A  77
SER A  78
THR A 129
 None
 0.45A 4luhA-2ixcA:
undetectable		 4luhA-2ixcA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jac GLUTAREDOXIN-1

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		3 VAL A   2
SER A   3
THR A   6
 None
 0.28A 4luhA-2jacA:
undetectable		 4luhA-2jacA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN

(Saccharomyces
cerevisiae;
Aequorea
victoria) 		PF00462
(Glutaredoxin)
PF01353
(GFP) 		3 VAL A 248
SER A 249
THR A 252
 None
 0.30A 4luhA-2jadA:
undetectable		 4luhA-2jadA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l0k STAGE III
SPORULATION PROTEIN
D

(Bacillus
subtilis) 		PF12116
(SpoIIID) 		3 VAL A  32
SER A  33
THR A  36
 None
 0.35A 4luhA-2l0kA:
undetectable		 4luhA-2l0kA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		3 VAL A 236
SER A 237
THR A 240
 None
 0.45A 4luhA-2mbrA:
undetectable		 4luhA-2mbrA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of7 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		3 VAL A  57
SER A  58
THR A  61
 None
 0.42A 4luhA-2of7A:
2.9		 4luhA-2of7A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paf LACTOSE OPERON
REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		3 VAL A 150
SER A 151
THR A 154
 None
 0.40A 4luhA-2pafA:
undetectable		 4luhA-2pafA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbx HEMAGGLUTININ/PROTEA
SE REGULATORY
PROTEIN

(Vibrio cholerae) 		PF00440
(TetR_N) 		3 VAL A  49
SER A  50
THR A  53
 None
 0.36A 4luhA-2pbxA:
4.3		 4luhA-2pbxA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v75 NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
NAB2

(Saccharomyces
cerevisiae) 		PF11517
(Nab2) 		3 VAL A  59
SER A  60
THR A  63
 None
 0.33A 4luhA-2v75A:
4.6		 4luhA-2v75A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xi8 PUTATIVE
TRANSCRIPTION
REGULATOR

(Enterococcus
faecalis) 		PF01381
(HTH_3) 		3 VAL A  26
SER A  27
THR A  30
 None
 0.39A 4luhA-2xi8A:
undetectable		 4luhA-2xi8A:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		3 VAL A 142
SER A 143
THR A 146
 None
 0.40A 4luhA-2yyyA:
2.1		 4luhA-2yyyA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb9 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		3 VAL A  55
SER A  56
THR A  59
 None
 0.21A 4luhA-2zb9A:
4.1		 4luhA-2zb9A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cec PUTATIVE ANTIDOTE
PROTEIN OF PLASMID
MAINTENANCE SYSTEM

(Nostoc
punctiforme) 		PF01381
(HTH_3) 		3 VAL A  42
SER A  43
THR A  46
 None
 0.37A 4luhA-3cecA:
2.6		 4luhA-3cecA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctf GLUTAREDOXIN-2

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		3 VAL A  36
SER A  37
THR A  40
 None
 0.32A 4luhA-3ctfA:
undetectable		 4luhA-3ctfA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4m GLUTAREDOXIN-2,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		3 VAL A   2
SER A   3
THR A   6
 None
 0.40A 4luhA-3d4mA:
undetectable		 4luhA-3d4mA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Staphylococcus
aureus) 		PF13460
(NAD_binding_10) 		3 VAL A 224
SER A 225
THR A 228
 None
 0.41A 4luhA-3e48A:
undetectable		 4luhA-3e48A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3s LAMBDA-CRYSTALLIN
HOMOLOG

(Homo sapiens) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 VAL A 143
SER A 121
THR A 123
 None
 0.40A 4luhA-3f3sA:
undetectable		 4luhA-3f3sA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp4 TRANSCRIPTIONAL
REGULATOR, MERR
FAMILY

(Listeria
monocytogenes) 		PF00376
(MerR)
PF09278
(MerR-DNA-bind) 		3 VAL A  30
SER A  31
THR A  34
 None
None
GOL  A   2 ( 4.6A)
 0.42A 4luhA-3gp4A:
3.8		 4luhA-3gp4A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hib PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF02889
(Sec63) 		3 VAL A1858
SER A1859
THR A1862
 None
 0.28A 4luhA-3hibA:
2.8		 4luhA-3hibA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 VAL A 340
SER A 341
THR A 344
 None
 0.35A 4luhA-3hn7A:
undetectable		 4luhA-3hn7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs2 PREVENT HOST DEATH
PROTEIN

(Escherichia
virus P1) 		PF02604
(PhdYeFM_antitox) 		3 VAL A  39
SER A  40
THR A  43
 None
 0.42A 4luhA-3hs2A:
undetectable		 4luhA-3hs2A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0p MALATE DEHYDROGENASE

(Entamoeba
histolytica) 		PF02615
(Ldh_2) 		3 VAL A   9
SER A  10
THR A  13
 None
GOL  A 402 (-2.9A)
GOL  A 402 (-4.1A)
 0.34A 4luhA-3i0pA:
undetectable		 4luhA-3i0pA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 VAL A 324
SER A 325
THR A 328
 None
 0.28A 4luhA-3imlA:
undetectable		 4luhA-3imlA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjl PROTEIN SUS1

(Saccharomyces
cerevisiae) 		PF10163
(EnY2) 		3 VAL A  73
SER A  74
THR A  77
 None
 0.22A 4luhA-3kjlA:
2.1		 4luhA-3kjlA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF00356
(LacI)
PF00532
(Peripla_BP_1) 		3 VAL A  20
SER A  21
THR A  24
 None
 0.47A 4luhA-3kjxA:
undetectable		 4luhA-3kjxA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF00356
(LacI)
PF00532
(Peripla_BP_1) 		3 VAL A  35
SER A  36
THR A  39
 None
 0.43A 4luhA-3kjxA:
undetectable		 4luhA-3kjxA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6q STAGE II SPORULATION
PROTEIN SB

(Bacillus
subtilis) 		PF14185
(SpoIISB_antitox) 		3 VAL B  33
SER B  34
THR B  37
 None
 0.47A 4luhA-3o6qB:
undetectable		 4luhA-3o6qB:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		3 VAL A  15
SER A  16
THR A  19
 None
 0.44A 4luhA-3oqnA:
undetectable		 4luhA-3oqnA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qao MERR-LIKE
TRANSCRIPTIONAL
REGULATOR

(Listeria
monocytogenes) 		PF07739
(TipAS)
PF13411
(MerR_1) 		3 VAL A  12
SER A  13
THR A  16
 None
 0.35A 4luhA-3qaoA:
undetectable		 4luhA-3qaoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqn CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF05043
(Mga) 		3 VAL A 117
SER A 118
THR A 121
 None
 0.42A 4luhA-3sqnA:
3.2		 4luhA-3sqnA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tju GRANZYME H

(Homo sapiens) 		PF00089
(Trypsin) 		3 VAL A 145
SER A 146
THR A 149
 None
 0.46A 4luhA-3tjuA:
undetectable		 4luhA-3tjuA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tni CYCLIN-T1

(Homo sapiens) 		PF00134
(Cyclin_N) 		3 VAL B  54
SER B  55
THR B  58
 None
 0.45A 4luhA-3tniB:
1.5		 4luhA-3tniB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tyr TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecalis) 		PF13443
(HTH_26) 		3 VAL A  49
SER A  50
THR A  53
 None
 0.31A 4luhA-3tyrA:
undetectable		 4luhA-3tyrA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfd SPASTIN

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		3 VAL A 597
SER A 598
THR A 601
 None
 0.44A 4luhA-3vfdA:
undetectable		 4luhA-3vfdA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxx ACRH

(Aeromonas
hydrophila) 		no annotation 3 VAL A  29
SER A  30
THR A  33
 None
 0.35A 4luhA-3wxxA:
2.4		 4luhA-3wxxA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0x TRANSCRIPTION FACTOR
FAPR

(Staphylococcus
aureus) 		PF03061
(4HBT) 		3 VAL A  38
SER A  39
THR A  42
 None
 0.43A 4luhA-4a0xA:
2.2		 4luhA-4a0xA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		3 VAL A 982
SER A 983
THR A 986
 None
 0.42A 4luhA-4czwA:
undetectable		 4luhA-4czwA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		3 VAL A 197
SER A 198
THR A 201
 None
 0.46A 4luhA-4f0sA:
undetectable		 4luhA-4f0sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htp DNA LIGASE 4

(Homo sapiens) 		PF04675
(DNA_ligase_A_N) 		3 VAL A 198
SER A 199
THR A 202
 None
 0.47A 4luhA-4htpA:
undetectable		 4luhA-4htpA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2n GP37

(Mycobacterium
virus Pukovnik) 		PF12728
(HTH_17) 		3 VAL A  16
SER A  17
THR A  20
 None
 0.46A 4luhA-4j2nA:
undetectable		 4luhA-4j2nA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1g PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Bacillus cereus) 		PF01522
(Polysacc_deac_1) 		3 VAL A 203
SER A 204
THR A 207
 None
 0.42A 4luhA-4l1gA:
undetectable		 4luhA-4l1gA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lms CRYPTOPHYTE
PHYCOCYANIN (ALPHA-1
CHAIN)

(Chroomonas sp.) 		PF02972
(Phycoerythr_ab) 		3 VAL A  48
SER A  49
THR A  52
 None
 0.38A 4luhA-4lmsA:
undetectable		 4luhA-4lmsA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		3 VAL A 363
SER A 364
THR A 367
 None
 0.47A 4luhA-4mnrA:
undetectable		 4luhA-4mnrA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		3 VAL B 564
SER B 565
THR B 568
 None
 0.48A 4luhA-4ni2B:
undetectable		 4luhA-4ni2B:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP

(Homo sapiens) 		PF00653
(BIR) 		3 VAL A  42
SER A  43
THR A  46
 None
 0.36A 4luhA-4oxcA:
undetectable		 4luhA-4oxcA:
11.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		3 VAL A 418
SER A 419
THR A 422
 None
 0.15A 4luhA-4po0A:
46.2		 4luhA-4po0A:
72.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qo5 HYPOTHETICAL
MULTIHEME PROTEIN

(Ignicoccus
hospitalis) 		PF13435
(Cytochrome_C554)
PF13447
(Multi-haem_cyto) 		3 VAL A  44
SER A  45
THR A  48
 None
 0.33A 4luhA-4qo5A:
4.4		 4luhA-4qo5A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpa PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01368
(DHH)
PF02833
(DHHA2) 		3 VAL A  43
SER A  44
THR A  47
 None
 0.47A 4luhA-4rpaA:
undetectable		 4luhA-4rpaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xd9 RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)

(Aspergillus
nidulans) 		PF04427
(Brix) 		3 VAL A  30
SER A  57
THR A  53
 None
 0.46A 4luhA-4xd9A:
undetectable		 4luhA-4xd9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgi GLUTAMATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 VAL A 409
SER A 410
THR A 413
 None
 0.42A 4luhA-4xgiA:
undetectable		 4luhA-4xgiA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrw BEXL

(Amycolatopsis
orientalis) 		PF10604
(Polyketide_cyc2) 		3 VAL A  98
SER A  99
THR A 102
 None
 0.31A 4luhA-4xrwA:
undetectable		 4luhA-4xrwA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		3 VAL A 335
SER A 336
THR A 339
 None
 0.18A 4luhA-4ymkA:
undetectable		 4luhA-4ymkA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0b ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H 191
SER H 192
THR H 195
 None
 0.31A 4luhA-4z0bH:
undetectable		 4luhA-4z0bH:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlx ANTITOXIN PHD

(Escherichia
virus P1) 		PF02604
(PhdYeFM_antitox) 		3 VAL A  39
SER A  40
THR A  43
 None
 0.48A 4luhA-4zlxA:
undetectable		 4luhA-4zlxA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by8 RPF2

(Aspergillus
nidulans) 		PF04427
(Brix) 		3 VAL A  30
SER A  57
THR A  53
 None
 0.42A 4luhA-5by8A:
undetectable		 4luhA-5by8A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnx AMINOPEPTIDASE YPDF

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 VAL A 100
SER A 101
THR A 104
 None
 0.36A 4luhA-5cnxA:
undetectable		 4luhA-5cnxA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4s ARABINOSE METABOLISM
TRANSCRIPTIONAL
REPRESSOR

(Bacillus
subtilis) 		PF00392
(GntR) 		3 VAL A  39
SER A  40
THR A  43
 None
 0.38A 4luhA-5d4sA:
undetectable		 4luhA-5d4sA:
8.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		3 VAL A 417
SER A 418
THR A 421
 None
 0.14A 4luhA-5dqfA:
47.8		 4luhA-5dqfA:
75.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 3 VAL A 818
SER A 819
THR A 822
 None
 0.15A 4luhA-5hdtA:
3.2		 4luhA-5hdtA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkq CDII IMMUNITY
PROTEIN

(Escherichia
coli) 		no annotation 3 VAL I  85
SER I  86
THR I  89
 None
 0.48A 4luhA-5hkqI:
undetectable		 4luhA-5hkqI:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1u GERMACRADIEN-4-OL
SYNTHASE

(Streptomyces
citricolor) 		no annotation 3 VAL A  40
SER A  41
THR A  44
 None
 0.44A 4luhA-5i1uA:
2.0		 4luhA-5i1uA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i41 CHROMOSOME-ANCHORING
PROTEIN RACA

(Bacillus
subtilis) 		PF13411
(MerR_1) 		3 VAL B  12
SER B  13
THR B  16
 None
 0.41A 4luhA-5i41B:
undetectable		 4luhA-5i41B:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6q CELL WALL BINDING
PROTEIN CWP8

(Clostridioides
difficile) 		PF04122
(CW_binding_2) 		3 VAL A 382
SER A 383
THR A 386
 None
 0.42A 4luhA-5j6qA:
undetectable		 4luhA-5j6qA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd5 MGS-MILE3

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		3 VAL A  17
SER A  18
THR A  21
 None
 0.47A 4luhA-5jd5A:
undetectable		 4luhA-5jd5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		3 VAL A  30
SER A  31
THR A  34
 None
 0.26A 4luhA-5jjhA:
2.5		 4luhA-5jjhA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17

(Homo sapiens) 		PF00293
(NUDIX) 		3 VAL A 278
SER A 279
THR A 282
 None
PO4  A 401 (-3.7A)
None
 0.35A 4luhA-5lf8A:
undetectable		 4luhA-5lf8A:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 3 VAL A 417
SER A 418
THR A 421
 None
 0.13A 4luhA-5oriA:
46.6		 4luhA-5oriA:
98.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7x NOD FACTOR BINDING
LECTIN-NUCLEOTIDE
PHOSPHOHYDROLASE

(Vigna
unguiculata) 		PF01150
(GDA1_CD39) 		3 VAL F 170
SER F 171
THR F 174
 None
 0.34A 4luhA-5u7xF:
undetectable		 4luhA-5u7xF:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 3 VAL A 419
SER A 420
THR A 423
 None
 0.43A 4luhA-5w21A:
undetectable		 4luhA-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x15 PUTATIVE TRANSFERASE

(Streptomyces
coelicolor) 		PF03737
(RraA-like) 		3 VAL A  46
SER A  47
THR A  50
 None
 0.36A 4luhA-5x15A:
undetectable		 4luhA-5x15A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 VAL A 335
SER A 336
THR A 339
 None
 0.45A 4luhA-5xxoA:
2.6		 4luhA-5xxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axf RAS GUANYL-RELEASING
PROTEIN 2

(Homo sapiens) 		no annotation 3 VAL A 265
SER A 266
THR A 269
 None
 0.46A 4luhA-6axfA:
2.8		 4luhA-6axfA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekv TOXIN COMPLEX
COMPONENT ORF-X2

(Clostridium
botulinum) 		no annotation 3 VAL A 181
SER A 182
THR A 185
 None
 0.44A 4luhA-6ekvA:
2.9		 4luhA-6ekvA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 3 VAL A  60
SER A  61
THR A  64
 None
 0.39A 4luhA-6f5dA:
undetectable		 4luhA-6f5dA:
undetectable