SIMILAR PATTERNS OF AMINO ACIDS FOR 4LTW_A_STRA301_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awc PROTEIN (GA BINDING
PROTEIN ALPHA)
PROTEIN (GA BINDING
PROTEIN BETA 1)


(Mus musculus)
PF00178
(Ets)
PF12796
(Ank_2)
PF13637
(Ank_4)
4 TRP B 110
THR A 331
VAL A 418
PHE B 136
None
0.96A 4ltwA-1awcB:
undetectable
4ltwA-1awcB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
4 ALA A 606
PHE A 570
THR A 538
PHE A 583
None
1.03A 4ltwA-1ciyA:
undetectable
4ltwA-1ciyA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dly HEMOGLOBIN

(Chlamydomonas
moewusii)
PF01152
(Bac_globin)
4 ALA A  15
THR A 111
VAL A 115
PHE A  80
None
HEM  A 144 ( 4.1A)
None
HEM  A 144 (-4.4A)
0.77A 4ltwA-1dlyA:
undetectable
4ltwA-1dlyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dml DNA POLYMERASE
PROCESSIVITY FACTOR


(Human
alphaherpesvirus
1)
PF02282
(Herpes_UL42)
4 ALA A 303
THR A 192
VAL A 212
PHE A 202
None
1.04A 4ltwA-1dmlA:
undetectable
4ltwA-1dmlA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli)
PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2)
4 MET A 172
THR A 532
VAL A 536
PHE A 540
None
0.87A 4ltwA-1fuiA:
undetectable
4ltwA-1fuiA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2


(Mus musculus)
PF09258
(Glyco_transf_64)
4 MET A 249
ALA A 248
VAL A  99
PHE A 139
None
0.94A 4ltwA-1omxA:
undetectable
4ltwA-1omxA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER


(Rhodobacter
sphaeroides)
PF00124
(Photo_RC)
4 ALA M 273
PHE M 150
THR M 133
PHE L 215
BPH  M   5 (-4.2A)
BPH  M   5 (-3.7A)
BPH  M   5 ( 4.2A)
None
1.00A 4ltwA-1pssM:
undetectable
4ltwA-1pssM:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli)
PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH)
4 ALA A  28
THR A  56
VAL A  44
PHE A  58
None
0.96A 4ltwA-1q3bA:
undetectable
4ltwA-1q3bA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgi PROTEIN
(CHITOSANASE)


(Bacillus
circulans)
PF01374
(Glyco_hydro_46)
4 MET A 109
THR A 143
VAL A 147
PHE A  64
None
0.99A 4ltwA-1qgiA:
undetectable
4ltwA-1qgiA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qx6 NPQTN SPECIFIC
SORTASE B


(Staphylococcus
aureus)
PF04203
(Sortase)
4 PHE A 195
THR A 199
VAL A 237
PHE A 170
None
0.93A 4ltwA-1qx6A:
undetectable
4ltwA-1qx6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE


(Streptococcus
pneumoniae)
PF00275
(EPSP_synthase)
4 ALA A 180
MET A 132
THR A 196
PHE A  29
None
1.04A 4ltwA-1rf5A:
undetectable
4ltwA-1rf5A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE


(Zea mays)
PF00903
(Glyoxalase)
4 ALA A 160
THR A  46
VAL A 270
PHE A 240
None
1.01A 4ltwA-1sp8A:
undetectable
4ltwA-1sp8A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER


(Escherichia
coli)
PF00909
(Ammonium_transp)
4 TRP A 135
ALA A 108
VAL A 314
PHE A 315
None
None
BOG  A 400 ( 4.0A)
None
1.03A 4ltwA-1u7gA:
undetectable
4ltwA-1u7gA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvx GLOBIN LI637

(Chlamydomonas
moewusii)
PF01152
(Bac_globin)
4 ALA A  15
THR A 111
VAL A 115
PHE A  80
XE  A1127 ( 3.9A)
HEM  A1122 (-4.3A)
HEM  A1122 (-4.9A)
HEM  A1122 (-3.7A)
0.74A 4ltwA-1uvxA:
undetectable
4ltwA-1uvxA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkh PUTATIVE SERINE
HYDROLASE


(Saccharomyces
cerevisiae)
PF07859
(Abhydrolase_3)
4 ALA A 122
MET A 137
PHE A 115
PHE A 174
None
1.03A 4ltwA-1vkhA:
undetectable
4ltwA-1vkhA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN


(Homo sapiens)
PF01424
(R3H)
PF04857
(CAF1)
4 MET A 328
ALA A 329
VAL A 360
PHE A  74
None
1.00A 4ltwA-2a1rA:
undetectable
4ltwA-2a1rA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
5 MET A 745
MET A 787
PHE A 876
VAL A 889
PHE A 891
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
None
None
None
0.86A 4ltwA-2ax9A:
36.1
4ltwA-2ax9A:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
5 TRP A 741
MET A 787
PHE A 876
VAL A 889
PHE A 891
None
BHM  A   1 (-3.6A)
None
None
None
1.25A 4ltwA-2ax9A:
36.1
4ltwA-2ax9A:
60.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum)
PF12891
(Glyco_hydro_44)
4 ALA A 373
THR A 459
VAL A  10
PHE A 461
None
0.95A 4ltwA-2e0pA:
undetectable
4ltwA-2e0pA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Aquifex
aeolicus)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 MET A 293
ALA A 304
MET A 179
VAL A 133
None
1.03A 4ltwA-2ebdA:
undetectable
4ltwA-2ebdA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE


(Thermus
thermophilus)
PF00596
(Aldolase_II)
4 ALA A 153
MET A 173
PHE A  29
THR A  40
None
0.99A 4ltwA-2fk5A:
undetectable
4ltwA-2fk5A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE


(Thermus
thermophilus)
PF00596
(Aldolase_II)
4 ALA A 153
PHE A  29
THR A  40
VAL A  44
None
0.96A 4ltwA-2fk5A:
undetectable
4ltwA-2fk5A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0a TRANSCRIPTIONAL
REGULATOR


(Thermus
thermophilus)
PF13377
(Peripla_BP_3)
4 ALA A 285
PHE A  77
VAL A 197
PHE A 198
None
0.89A 4ltwA-2h0aA:
undetectable
4ltwA-2h0aA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR


(unidentified)
PF00104
(Hormone_recep)
8 TRP A  69
MET A  73
ALA A  74
MET A 115
PHE A 204
THR A 208
VAL A 217
PHE A 219
None
1CA  A 247 (-3.6A)
1CA  A 247 ( 4.4A)
1CA  A 247 ( 3.7A)
1CA  A 247 (-4.7A)
1CA  A 247 (-3.4A)
None
1CA  A 247 (-4.5A)
0.34A 4ltwA-2q3yA:
40.6
4ltwA-2q3yA:
90.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qru UNCHARACTERIZED
PROTEIN


(Enterococcus
faecalis)
PF07859
(Abhydrolase_3)
4 PHE A 212
THR A 214
VAL A 242
PHE A 249
None
1.00A 4ltwA-2qruA:
undetectable
4ltwA-2qruA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1h HEMOGLOBIN SUBUNIT
ALPHA-4
HEMOGLOBIN SUBUNIT
BETA-4


(Oncorhynchus
mykiss)
PF00042
(Globin)
4 TRP A  14
MET A  64
VAL B 112
PHE A 118
None
1.03A 4ltwA-2r1hA:
undetectable
4ltwA-2r1hA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmh FIBRONECTIN TYPE III
DOMAIN PROTEIN


(Clostridium
perfringens)
PF08305
(NPCBM)
4 ALA A 918
THR A 975
VAL A1016
PHE A 973
None
1.03A 4ltwA-2vmhA:
undetectable
4ltwA-2vmhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT


(Homo sapiens)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
4 TRP A 581
ALA A 700
THR A 470
VAL A 474
None
1.00A 4ltwA-2wghA:
undetectable
4ltwA-2wghA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN


(Streptomyces
coelicolor)
PF01497
(Peripla_BP_2)
4 ALA A 293
THR A 141
VAL A 171
PHE A 143
None
1.02A 4ltwA-2x4lA:
undetectable
4ltwA-2x4lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au0 CLUMPING FACTOR B

(Staphylococcus
aureus)
PF10425
(SdrG_C_C)
4 ALA A 334
THR A 393
VAL A 486
PHE A 395
None
1.04A 4ltwA-3au0A:
undetectable
4ltwA-3au0A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b85 PHOSPHATE
STARVATION-INDUCIBLE
PROTEIN


(Corynebacterium
glutamicum)
PF02562
(PhoH)
4 ALA A 201
MET A 205
PHE A 237
VAL A 137
SO4  A 409 ( 4.1A)
None
None
None
1.04A 4ltwA-3b85A:
undetectable
4ltwA-3b85A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT


(Methanosarcina
barkeri)
PF02552
(CO_dh)
4 ALA G  45
PHE G 151
THR G   4
VAL G   2
ACY  A 819 ( 4.3A)
None
None
None
0.95A 4ltwA-3cf4G:
undetectable
4ltwA-3cf4G:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cny INOSITOL CATABOLISM
PROTEIN IOLE


(Lactobacillus
plantarum)
PF01261
(AP_endonuc_2)
4 MET A 285
ALA A 286
PHE A 216
THR A 190
None
0.90A 4ltwA-3cnyA:
undetectable
4ltwA-3cnyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN


(Mus musculus)
PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind)
4 MET A 321
ALA A 322
VAL A 353
PHE A  74
None
0.93A 4ltwA-3d45A:
undetectable
4ltwA-3d45A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emq ENDO-1,4-BETA-XYLANA
SE


(Paenibacillus
barcinonensis)
PF00331
(Glyco_hydro_10)
4 MET A 263
ALA A 264
PHE A 313
THR A 298
None
0.99A 4ltwA-3emqA:
undetectable
4ltwA-3emqA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa3 2,3-DIMETHYLMALATE
LYASE


(Aspergillus
niger)
PF13714
(PEP_mutase)
4 MET A 251
ALA A 249
PHE A 241
THR A  46
None
None
None
OAF  A 501 (-3.3A)
0.89A 4ltwA-3fa3A:
undetectable
4ltwA-3fa3A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flj UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA WITH A
CYSTATIN-LIKE FOLD


(Ruegeria
pomeroyi)
PF12680
(SnoaL_2)
4 ALA A 120
PHE A  56
VAL A 103
PHE A  30
None
1.00A 4ltwA-3fljA:
undetectable
4ltwA-3fljA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwr YQZB PROTEIN

(Bacillus
subtilis)
PF00571
(CBS)
4 ALA A 167
THR A 110
VAL A 123
PHE A 112
None
ADP  A 221 ( 3.9A)
None
None
0.97A 4ltwA-3fwrA:
undetectable
4ltwA-3fwrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C)
4 ALA A 867
PHE A 903
VAL A 671
PHE A 673
None
0.95A 4ltwA-3hmjA:
undetectable
4ltwA-3hmjA:
8.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 MET A 759
MET A 801
THR A 894
VAL A 903
PHE A 905
WOW  A   1 (-3.7A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
None
WOW  A   1 (-4.6A)
0.59A 4ltwA-3kbaA:
36.7
4ltwA-3kbaA:
66.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 TRP A 755
MET A 801
THR A 894
VAL A 903
PHE A 905
None
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
None
WOW  A   1 (-4.6A)
1.01A 4ltwA-3kbaA:
36.7
4ltwA-3kbaA:
66.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2


(Sulfolobus
solfataricus)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
4 ALA A 199
MET A 217
THR A  61
VAL A 146
None
0.96A 4ltwA-3l7zA:
undetectable
4ltwA-3l7zA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pow CALRETICULIN

(Homo sapiens)
PF00262
(Calreticulin)
4 ALA A  76
MET A 122
VAL A  93
PHE A  95
None
1.04A 4ltwA-3powA:
undetectable
4ltwA-3powA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg0 CALRETICULIN

(Mus musculus)
PF00262
(Calreticulin)
4 ALA A  76
MET A 122
VAL A  93
PHE A  95
None
1.00A 4ltwA-3rg0A:
undetectable
4ltwA-3rg0A:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1


(synthetic
construct)
PF00104
(Hormone_recep)
8 TRP A  69
MET A  73
ALA A  74
MET A 115
PHE A 204
THR A 208
VAL A 217
PHE A 219
None
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.7A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.8A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.9A)
1CA  A 249 (-4.3A)
0.51A 4ltwA-3ry9A:
38.4
4ltwA-3ry9A:
81.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE


(Arabidopsis
thaliana)
PF00202
(Aminotran_3)
PF13500
(AAA_26)
4 MET A 441
ALA A 442
PHE A 614
PHE A 642
None
1.01A 4ltwA-4a0hA:
undetectable
4ltwA-4a0hA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anf ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC


(Mycoplasma
penetrans)
PF00185
(OTCace)
PF02729
(OTCace_N)
4 ALA A 226
PHE A 162
THR A 174
PHE A 145
None
1.04A 4ltwA-4anfA:
undetectable
4ltwA-4anfA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1r MANNOSYL-6-PHOSPHATA
SE


(Bacteroides
thetaiotaomicron)
PF03372
(Exo_endo_phos)
4 MET A  58
ALA A  56
MET A  80
PHE A 237
None
0.99A 4ltwA-4c1rA:
undetectable
4ltwA-4c1rA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4


(Homo sapiens)
PF13561
(adh_short_C2)
4 ALA B  19
THR B 114
VAL B  63
PHE B  67
None
1.00A 4ltwA-4cqmB:
undetectable
4ltwA-4cqmB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5v PUTATIVE THUA-LIKE
PROTEIN


(Parabacteroides
merdae)
PF06283
(ThuA)
4 PHE A 265
THR A 245
VAL A 113
PHE A 243
None
0.96A 4ltwA-4e5vA:
undetectable
4ltwA-4e5vA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN


(Homo sapiens)
PF01857
(RB_B)
PF01858
(RB_A)
PF11934
(DUF3452)
4 MET A 148
ALA A 147
THR A  77
VAL A  81
None
1.02A 4ltwA-4eljA:
undetectable
4ltwA-4eljA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri)
PF13412
(HTH_24)
PF14520
(HHH_5)
4 ALA A 113
THR A 333
VAL A 337
PHE A 319
None
0.97A 4ltwA-4gfjA:
undetectable
4ltwA-4gfjA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7h EVAA 2,3-DEHYDRATASE

(Amycolatopsis
orientalis)
PF03559
(Hexose_dehydrat)
4 MET A 229
ALA A 226
THR A 443
VAL A 449
None
0.97A 4ltwA-4j7hA:
undetectable
4ltwA-4j7hA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7k CATION EFFLUX SYSTEM
PROTEIN CUSC


(Escherichia
coli)
PF02321
(OEP)
4 ALA A 129
THR A  64
VAL A 144
PHE A 119
None
1.00A 4ltwA-4k7kA:
undetectable
4ltwA-4k7kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP


(Aspergillus
fumigatus)
PF02128
(Peptidase_M36)
4 MET A 465
ALA A 466
PHE A 395
THR A 397
None
1.00A 4ltwA-4k90A:
undetectable
4ltwA-4k90A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE


(Thermus
thermophilus)
PF00270
(DEAD)
PF00271
(Helicase_C)
4 ALA A 153
MET A 156
THR A 172
VAL A 145
None
0.90A 4ltwA-4kbfA:
undetectable
4ltwA-4kbfA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kva SEPTIN

(Schistosoma
mansoni)
PF00735
(Septin)
4 MET A 169
ALA A 168
THR A 157
PHE A 196
None
0.65A 4ltwA-4kvaA:
undetectable
4ltwA-4kvaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3w LIPASE

(Rhizopus
microsporus)
PF01764
(Lipase_3)
4 ALA A  99
THR A  53
VAL A  59
PHE A  93
None
0.80A 4ltwA-4l3wA:
undetectable
4ltwA-4l3wA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae)
PF00873
(ACR_tran)
4 ALA A 461
PHE A 935
THR A1013
VAL A 942
None
1.02A 4ltwA-4mt1A:
undetectable
4ltwA-4mt1A:
13.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
4 TRP A 320
PHE A 450
VAL A 460
PHE A 462
None
0.60A 4ltwA-4n1yA:
29.6
4ltwA-4n1yA:
31.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE


(Geobacter
sulfurreducens)
PF00171
(Aldedh)
PF01619
(Pro_dh)
4 MET A 816
ALA A 817
MET A 873
THR A 948
None
0.92A 4ltwA-4nmeA:
undetectable
4ltwA-4nmeA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqr CYP105AS1

(Amycolatopsis
orientalis)
PF00067
(p450)
4 ALA A 271
THR A 129
VAL A 153
PHE A 149
None
0.81A 4ltwA-4oqrA:
2.4
4ltwA-4oqrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqs CYP105AS1

(Amycolatopsis
orientalis)
PF00067
(p450)
4 ALA A 271
THR A 129
VAL A 153
PHE A 149
None
0.80A 4ltwA-4oqsA:
3.2
4ltwA-4oqsA:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 TRP A 600
ALA A 605
MET A 646
THR A 739
PHE A 749
None
MOF  A 801 ( 4.8A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
0.75A 4ltwA-4p6wA:
36.6
4ltwA-4p6wA:
62.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 TRP A 600
MET A 604
ALA A 605
MET A 646
PHE A 749
None
None
MOF  A 801 ( 4.8A)
MOF  A 801 (-4.4A)
MOF  A 801 (-4.4A)
0.87A 4ltwA-4p6wA:
36.6
4ltwA-4p6wA:
62.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE


(Brucella
abortus)
PF01370
(Epimerase)
4 ALA A 298
THR A  19
VAL A   8
PHE A  75
None
1.01A 4ltwA-4twrA:
undetectable
4ltwA-4twrA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE


(Mycobacterium
tuberculosis)
PF00128
(Alpha-amylase)
PF11896
(DUF3416)
4 MET A 269
ALA A 267
MET A 339
THR A 242
None
0.97A 4ltwA-4u33A:
undetectable
4ltwA-4u33A:
15.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
6 TRP A 806
MET A 852
PHE A 941
THR A 945
VAL A 954
PHE A 956
None
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.6A)
CV7  A1987 (-3.1A)
None
CV7  A1987 ( 4.7A)
0.48A 4ltwA-4udbA:
36.1
4ltwA-4udbA:
65.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2i ESTERASE/LIPASE

(Thalassospira
sp. GB04J01)
PF07859
(Abhydrolase_3)
4 ALA A 107
THR A 135
VAL A 167
PHE A  83
None
1.02A 4ltwA-4v2iA:
undetectable
4ltwA-4v2iA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN


(Thielavia
terrestris)
PF07470
(Glyco_hydro_88)
4 ALA A 181
PHE A 252
THR A 256
PHE A 200
None
1.00A 4ltwA-4xuvA:
undetectable
4ltwA-4xuvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE


(Burkholderia
cenocepacia)
PF00171
(Aldedh)
4 ALA A 178
THR A 230
VAL A 234
PHE A 224
CA  A 503 ( 4.5A)
None
None
None
0.96A 4ltwA-4yweA:
undetectable
4ltwA-4yweA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE


(Tepidanaerobacter
acetatoxydans)
PF01268
(FTHFS)
4 MET A 205
ALA A 206
PHE A 312
THR A 299
None
1.03A 4ltwA-5a4jA:
undetectable
4ltwA-5a4jA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE


(Tepidanaerobacter
acetatoxydans)
PF01268
(FTHFS)
4 MET A 204
ALA A 205
PHE A 311
THR A 298
None
0.97A 4ltwA-5a5gA:
undetectable
4ltwA-5a5gA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn7 MALTODEXTRIN
GLUCOSIDASE


(Escherichia
coli)
PF00128
(Alpha-amylase)
4 ALA A 405
THR A 472
VAL A 555
PHE A 544
None
0.92A 4ltwA-5bn7A:
undetectable
4ltwA-5bn7A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Acinetobacter
baumannii)
PF00275
(EPSP_synthase)
4 ALA A 495
MET A 447
THR A 511
PHE A 343
None
0.99A 4ltwA-5bs5A:
undetectable
4ltwA-5bs5A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED


(Cupriavidus
metallidurans)
PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK)
4 PHE A 627
THR A 625
VAL A 676
PHE A 611
None
0.99A 4ltwA-5cjuA:
undetectable
4ltwA-5cjuA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1p PTMO8

(Streptomyces
platensis)
PF13561
(adh_short_C2)
4 ALA A  78
MET A  74
THR A  22
VAL A 226
None
1.04A 4ltwA-5f1pA:
undetectable
4ltwA-5f1pA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
4 MET A 448
ALA A 449
VAL A  74
PHE A 100
None
None
None
EDO  A1873 ( 4.0A)
0.86A 4ltwA-5fjiA:
undetectable
4ltwA-5fjiA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
4 MET A 448
ALA A 449
VAL A  75
PHE A 100
None
0.98A 4ltwA-5fjjA:
undetectable
4ltwA-5fjjA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxf ACRYLYL-COA
REDUCTASE ACUI


(Ruegeria
pomeroyi)
PF00107
(ADH_zinc_N)
4 MET A 293
PHE A 132
THR A  89
VAL A 113
None
1.02A 4ltwA-5gxfA:
undetectable
4ltwA-5gxfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri)
PF13412
(HTH_24)
PF14520
(HHH_5)
4 ALA A 113
THR A 333
VAL A 337
PHE A 319
None
1.01A 4ltwA-5hm5A:
undetectable
4ltwA-5hm5A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)


(Parageobacillus
thermoglucosidasius)
PF00171
(Aldedh)
4 MET A 180
ALA A 177
THR A 440
VAL A 455
None
0.99A 4ltwA-5j78A:
undetectable
4ltwA-5j78A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
4 MET A 166
ALA A 165
PHE A 289
THR A 102
None
1.00A 4ltwA-5jd4A:
undetectable
4ltwA-5jd4A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III


(Methanococcoides
burtonii)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
4 MET A 209
ALA A 211
VAL A 283
PHE A 261
None
0.98A 4ltwA-5macA:
undetectable
4ltwA-5macA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlh -

(-)
no annotation 4 ALA A 382
PHE A 207
VAL A 347
PHE A 343
None
None
XOG  A 402 (-3.6A)
NAP  A 404 ( 4.8A)
1.01A 4ltwA-5mlhA:
undetectable
4ltwA-5mlhA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
no annotation 5 TRP A 806
PHE A 941
THR A 945
VAL A 954
PHE A 956
None
ECV  A1101 (-4.3A)
ECV  A1101 (-3.2A)
None
ECV  A1101 ( 4.7A)
0.44A 4ltwA-5mwpA:
38.0
4ltwA-5mwpA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT


(Homo sapiens)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
4 TRP A 581
ALA A 700
THR A 470
VAL A 474
None
0.99A 4ltwA-5tusA:
undetectable
4ltwA-5tusA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uah RNA POLYMERASE SIGMA
FACTOR RPOD


(Escherichia
coli)
PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04546
(Sigma70_ner)
4 MET F 322
ALA F 321
PHE F 316
PHE F 306
None
0.96A 4ltwA-5uahF:
undetectable
4ltwA-5uahF:
16.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR


(Heterocephalus
glaber)
no annotation 4 TRP A 596
MET A 600
ALA A 601
MET A 642
None
None
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
0.41A 4ltwA-5uc1A:
25.2
4ltwA-5uc1A:
61.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2


(unidentified)
PF00104
(Hormone_recep)
7 TRP A  69
ALA A  74
MET A 115
PHE A 204
THR A 208
VAL A 216
PHE A 218
None
1TA  A 301 ( 3.7A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.7A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.3A)
1TA  A 301 (-4.0A)
0.62A 4ltwA-5ufsA:
38.4
4ltwA-5ufsA:
73.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2


(unidentified)
PF00104
(Hormone_recep)
7 TRP A  69
MET A  73
ALA A  74
MET A 115
THR A 208
VAL A 216
PHE A 218
None
1TA  A 301 (-4.2A)
1TA  A 301 ( 3.7A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.3A)
1TA  A 301 (-4.0A)
0.68A 4ltwA-5ufsA:
38.4
4ltwA-5ufsA:
73.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugj 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE


(Neisseria
meningitidis)
no annotation 4 ALA A 241
MET A  15
THR A 167
PHE A 134
None
1.03A 4ltwA-5ugjA:
undetectable
4ltwA-5ugjA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans)
PF03639
(Glyco_hydro_81)
4 PHE A 306
THR A 304
VAL A 269
PHE A 184
None
None
EDO  A 815 (-4.4A)
None
1.03A 4ltwA-5v1wA:
undetectable
4ltwA-5v1wA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE


(Mycolicibacterium
smegmatis)
no annotation 4 MET A 246
ALA A 247
THR A 616
VAL A 612
None
0.86A 4ltwA-5v9xA:
undetectable
4ltwA-5v9xA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xkt UREASE ACCESSORY
PROTEIN UREG


(Klebsiella
pneumoniae)
no annotation 4 MET A  31
ALA A  30
THR A 180
PHE A 147
None
0.80A 4ltwA-5xktA:
undetectable
4ltwA-5xktA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygk -

(-)
no annotation 4 ALA A  52
PHE A  36
VAL A  45
PHE A 115
None
0.84A 4ltwA-5ygkA:
undetectable
4ltwA-5ygkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1


(Danio rerio)
no annotation 4 PHE A 208
THR A 189
VAL A 315
PHE A 311
None
None
None
ACT  A 603 ( 4.4A)
0.89A 4ltwA-6b82A:
2.0
4ltwA-6b82A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE


(Marinobacter
hydrocarbonoclasticus)
no annotation 4 ALA A 313
MET A 333
VAL A 421
PHE A 423
None
0.86A 4ltwA-6chjA:
undetectable
4ltwA-6chjA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g47 FIBER-1

(Human
mastadenovirus
G)
no annotation 4 ALA A 332
PHE A 253
VAL A 232
PHE A 357
None
0.94A 4ltwA-6g47A:
undetectable
4ltwA-6g47A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-)
no annotation 4 ALA A 401
PHE A 356
THR A 349
PHE A 474
None
0.69A 4ltwA-6gneA:
undetectable
4ltwA-6gneA:
undetectable