SIMILAR PATTERNS OF AMINO ACIDS FOR 4LTW_A_STRA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 LEU A 244
ASN A 245
LEU A 248
GLN A 252
LEU A  61
 None
 0.99A 4ltwA-1g8kA:
undetectable		 4ltwA-1g8kA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdf SPHERULIN 3A

(Physarum
polycephalum) 		PF08964
(Crystall_3) 		5 LEU A  82
ASN A  88
LEU A  87
ALA A  90
MET A  94
 None
CA  A1101 ( 4.6A)
None
CA  A1102 (-4.4A)
None
 1.08A 4ltwA-1hdfA:
undetectable		 4ltwA-1hdfA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU C 422
LEU C 389
LEU C 353
ALA C 354
LEU C 427
 None
 1.10A 4ltwA-1n8yC:
undetectable		 4ltwA-1n8yC:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
LEU A 349
ALA A 350
ARG A 394
MET A 421
 EST  A   1 (-4.4A)
EST  A   1 ( 4.8A)
EST  A   1 ( 3.7A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
 0.53A 4ltwA-1pcgA:
28.5		 4ltwA-1pcgA:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		5 LEU A 755
LEU A 756
LEU A 760
ALA A 764
LEU A 749
 None
 1.15A 4ltwA-1qu2A:
undetectable		 4ltwA-1qu2A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qx8 REGULATORY PROTEIN
ROP

(Escherichia
coli) 		PF01815
(Rop) 		5 LEU A  23
LEU A  26
ASN A  27
LEU A  29
ALA A  30
 None
 0.44A 4ltwA-1qx8A:
undetectable		 4ltwA-1qx8A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC

(Shigella
flexneri) 		PF03932
(CutC) 		5 LEU A 131
LEU A 134
ASN A 135
LEU A 137
ALA A 138
 None
 0.76A 4ltwA-1twdA:
undetectable		 4ltwA-1twdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		5 LEU A  83
LEU A  69
LEU A  72
ALA A  73
GLN A  76
 None
 0.89A 4ltwA-1x9sA:
undetectable		 4ltwA-1x9sA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkp CHAPERONE PROTEIN
SYCN

(Yersinia pestis) 		no annotation 5 LEU B  50
ALA B 109
GLN B 108
MET B  31
LEU B  15
 None
 1.15A 4ltwA-1xkpB:
undetectable		 4ltwA-1xkpB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		5 LEU A  36
LEU A  33
LEU A  61
ALA A  30
GLN A  27
 None
 1.10A 4ltwA-1xviA:
undetectable		 4ltwA-1xviA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		5 LEU A 233
LEU A 232
ALA A 231
GLN A 104
LEU A 217
 None
 1.19A 4ltwA-1ycnA:
undetectable		 4ltwA-1ycnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yo7 REGULATORY PROTEIN
ROP

(Escherichia
coli) 		PF01815
(Rop) 		5 LEU A 111
LEU A 114
ASN A 115
LEU A 117
ALA A 118
 None
 0.90A 4ltwA-1yo7A:
undetectable		 4ltwA-1yo7A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvk HYPOTHETICAL PROTEIN
BSU33890

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		5 LEU A  18
LEU A  21
LEU A  24
ALA A  25
LEU A  84
 None
None
None
COA  A 201 (-3.6A)
None
 1.16A 4ltwA-1yvkA:
undetectable		 4ltwA-1yvkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		5 LEU A 691
LEU A 694
LEU A 697
ALA A 698
LEU A 257
 None
 1.03A 4ltwA-2a3lA:
undetectable		 4ltwA-2a3lA:
17.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 701
LEU A 704
ASN A 705
LEU A 707
GLN A 711
MET A 742
ARG A 752
MET A 780
LEU A 873
 None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-4.4A)
 0.69A 4ltwA-2ax9A:
36.1		 4ltwA-2ax9A:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 701
LEU A 704
LEU A 707
GLN A 711
MET A 742
MET A 749
ARG A 752
MET A 780
LEU A 873
 None
BHM  A   1 (-4.0A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-4.4A)
 0.83A 4ltwA-2ax9A:
36.1		 4ltwA-2ax9A:
60.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
GAMMA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 LEU E 457
LEU E 460
LEU E 463
ALA E 464
CYH E 229
 None
 1.07A 4ltwA-2bg9E:
undetectable		 4ltwA-2bg9E:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bku IMPORTIN BETA-1
SUBUNIT

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 LEU B 199
LEU B 202
ASN B 203
LEU B 205
ALA B 206
 None
 0.70A 4ltwA-2bkuB:
undetectable		 4ltwA-2bkuB:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4p HYPOTHETICAL PROTEIN
TTHA1254

(Thermus
thermophilus) 		PF09390
(DUF1999) 		5 LEU A  11
LEU A  14
ASN A  15
LEU A  17
ALA A  18
 None
 0.98A 4ltwA-2d4pA:
undetectable		 4ltwA-2d4pA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef0 ORNITHINE
CARBAMOYLTRANSFERASE

(Thermus
thermophilus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  23
LEU A  26
LEU A  29
ALA A  30
LEU A 136
 None
 0.80A 4ltwA-2ef0A:
undetectable		 4ltwA-2ef0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 265
LEU A 268
LEU A 271
ALA A 272
MET A 306
ARG A 316
 None
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
 0.40A 4ltwA-2gpvA:
26.4		 4ltwA-2gpvA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 271
LEU A 268
LEU A 265
ALA A 264
LEU A 324
 OHT  A 500 ( 4.4A)
OHT  A 500 (-4.1A)
None
None
None
 1.20A 4ltwA-2gpvA:
26.4		 4ltwA-2gpvA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 LEU A 556
LEU A 559
LEU A 562
ALA A 563
MET A  61
 None
 0.76A 4ltwA-2h4tA:
2.2		 4ltwA-2h4tA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		5 LEU A 134
LEU A 131
LEU A 127
ALA A 126
LEU A  91
 None
 1.17A 4ltwA-2i5bA:
undetectable		 4ltwA-2i5bA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4b TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT
72/90-100 KDA

(Encephalitozoon
cuniculi) 		PF04494
(TFIID_NTD2) 		5 LEU A 134
LEU A 137
ASN A 138
LEU A 141
MET A 113
 None
 0.95A 4ltwA-2j4bA:
undetectable		 4ltwA-2j4bA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5e UNCHARACTERIZED
PROTEIN

(Methanocaldococcus
jannaschii) 		PF08984
(DUF1858) 		6 LEU A  58
LEU A  61
ASN A  62
LEU A  64
ALA A  65
MET A   9
 None
 1.24A 4ltwA-2k5eA:
undetectable		 4ltwA-2k5eA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o42 M11L PROTEIN

(Myxoma virus) 		PF11099
(M11L) 		5 LEU A  81
LEU A  84
LEU A  87
ALA A  88
LEU A  27
 None
 1.12A 4ltwA-2o42A:
undetectable		 4ltwA-2o42A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6r VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A  82
LEU A 106
LEU A 130
ALA A 129
LEU A 101
 None
 1.11A 4ltwA-2o6rA:
undetectable		 4ltwA-2o6rA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
LEU A 349
ALA A 350
ARG A 394
MET A 421
 EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
EST  A 596 ( 3.9A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
 0.50A 4ltwA-2ocfA:
29.6		 4ltwA-2ocfA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 145
LEU A 146
ALA A 333
MET A 291
LEU A 374
 None
 1.00A 4ltwA-2ppgA:
undetectable		 4ltwA-2ppgA:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		11 LEU A  29
LEU A  32
ASN A  33
LEU A  35
ALA A  36
GLN A  39
MET A  70
ARG A  80
MET A 108
LEU A 201
CYH A 205
 1CA  A 247 ( 3.6A)
1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
1CA  A 247 ( 4.2A)
1CA  A 247 (-4.0A)
 0.23A 4ltwA-2q3yA:
40.6		 4ltwA-2q3yA:
90.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc3 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		5 LEU A 168
LEU A 171
LEU A 174
ALA A 175
LEU A 187
 None
 1.12A 4ltwA-2qc3A:
undetectable		 4ltwA-2qc3A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgh DIAMINOPIMELATE
DECARBOXYLASE

(Helicobacter
pylori) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A  51
LEU A  54
LEU A  57
ALA A  58
LEU A  76
 None
 0.89A 4ltwA-2qghA:
undetectable		 4ltwA-2qghA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmx PREPHENATE
DEHYDRATASE

(Chlorobaculum
tepidum) 		PF00800
(PDT) 		5 LEU A 262
ASN A 261
LEU A 259
ALA A 258
LEU A 215
 None
 0.84A 4ltwA-2qmxA:
undetectable		 4ltwA-2qmxA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		6 LEU A 372
LEU A 375
LEU A 378
ALA A 379
GLN A 382
LEU A 521
 None
 1.09A 4ltwA-2qveA:
undetectable		 4ltwA-2qveA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z55 ARCHAERHODOPSIN-2

(Halobacterium
sp. AUS-2) 		PF01036
(Bac_rhodopsin) 		5 LEU A  99
LEU A 102
LEU A 105
ALA A 106
LEU A 158
 None
 0.63A 4ltwA-2z55A:
undetectable		 4ltwA-2z55A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beh MLL3241 PROTEIN

(Mesorhizobium
loti) 		PF07885
(Ion_trans_2) 		5 LEU A 109
LEU A 106
LEU A  80
ALA A  81
LEU A  22
 None
 1.19A 4ltwA-3behA:
undetectable		 4ltwA-3behA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		no annotation 5 LEU B 970
LEU B 973
LEU B 976
ALA B 977
LEU B 938
 None
 0.83A 4ltwA-3cqcB:
undetectable		 4ltwA-3cqcB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE

(Corynebacterium
diphtheriae) 		PF12897
(Aminotran_MocR) 		5 LEU A 290
ASN A 291
LEU A 293
ALA A 294
GLN A 297
 None
 0.76A 4ltwA-3d6kA:
undetectable		 4ltwA-3d6kA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis) 		PF05163
(DinB) 		5 LEU A  78
ASN A  79
LEU A  81
ALA A  82
LEU A 135
 None
 0.92A 4ltwA-3dkaA:
undetectable		 4ltwA-3dkaA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LEU A1021
ASN A1024
LEU A1022
ALA A1023
LEU A1110
 None
 1.11A 4ltwA-3eh1A:
undetectable		 4ltwA-3eh1A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA

(Escherichia
coli) 		PF06144
(DNA_pol3_delta)
PF14840
(DNA_pol3_delt_C) 		5 LEU A 236
LEU A 233
LEU A 230
ALA A 229
LEU A 250
 None
 1.18A 4ltwA-3glgA:
undetectable		 4ltwA-3glgA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 LEU A  36
LEU A 150
ALA A 151
GLN A 155
LEU A  28
 None
 1.03A 4ltwA-3hd8A:
undetectable		 4ltwA-3hd8A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4r NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		PF03177
(Nucleoporin_C) 		5 LEU B 970
LEU B 973
LEU B 976
ALA B 977
LEU B 938
 None
 0.81A 4ltwA-3i4rB:
undetectable		 4ltwA-3i4rB:
16.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 715
ASN A 719
LEU A 721
GLN A 725
MET A 756
ARG A 766
LEU A 887
CYH A 891
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
 0.61A 4ltwA-3kbaA:
36.7		 4ltwA-3kbaA:
66.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 715
LEU A 718
ASN A 719
LEU A 721
MET A 756
ARG A 766
LEU A 887
CYH A 891
 WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
 0.37A 4ltwA-3kbaA:
36.7		 4ltwA-3kbaA:
66.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kux PUTATIVE
OXIDOREDUCTASE

(Yersinia pestis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A 343
LEU A 195
ASN A 196
LEU A 216
LEU A 199
 None
 1.20A 4ltwA-3kuxA:
undetectable		 4ltwA-3kuxA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 5 LEU X 564
LEU X 561
LEU X 512
ALA X 511
LEU X 235
 None
 0.93A 4ltwA-3kvnX:
undetectable		 4ltwA-3kvnX:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		5 LEU A 138
LEU A 141
LEU A 144
ALA A 145
MET A 164
 None
 1.01A 4ltwA-3l6aA:
undetectable		 4ltwA-3l6aA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2b DIAMINOPIMELATE
DECARBOXYLASE

(Vibrio cholerae) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A  66
LEU A  69
ASN A  70
LEU A  72
ALA A  73
 None
 1.10A 4ltwA-3n2bA:
undetectable		 4ltwA-3n2bA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odp PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Clostridium
novyi) 		PF01380
(SIS) 		5 LEU A 353
ASN A 354
LEU A 352
ALA A 355
LEU A   5
 None
 1.17A 4ltwA-3odpA:
undetectable		 4ltwA-3odpA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 LEU N  79
LEU N  82
LEU N  85
ALA N  86
LEU N 463
 LFA  N 488 ( 4.8A)
None
None
None
None
 0.64A 4ltwA-3rkoN:
undetectable		 4ltwA-3rkoN:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
MET A 108
LEU A 201
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
 0.28A 4ltwA-3ry9A:
38.4		 4ltwA-3ry9A:
81.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
SUBUNIT D
V-TYPE ATP SYNTHASE
SUBUNIT F

(Thermus
thermophilus) 		PF01813
(ATP-synt_D)
PF01990
(ATP-synt_F) 		5 LEU H  71
LEU H  72
LEU G 137
MET G  47
LEU G 147
 None
 1.10A 4ltwA-3w3aH:
undetectable		 4ltwA-3w3aH:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnw FERRITIN HEAVY CHAIN

(Mus musculus) 		PF00210
(Ferritin) 		5 LEU A 114
LEU A 117
LEU A 120
ALA A 121
LEU A  72
 None
 0.96A 4ltwA-3wnwA:
undetectable		 4ltwA-3wnwA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvi TYPE-2 RESTRICTION
ENZYME HINDIII

(Haemophilus
influenzae) 		PF09518
(RE_HindIII) 		5 LEU A 180
LEU A 175
LEU A 172
ALA A 173
LEU A 230
 None
 1.05A 4ltwA-3wviA:
undetectable		 4ltwA-3wviA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am9 CHAPERONE SYCD

(Yersinia
enterocolitica) 		PF07720
(TPR_3) 		6 LEU A  36
LEU A  39
LEU A  42
ALA A  43
GLN A  46
CYH A  63
 None
 0.79A 4ltwA-4am9A:
undetectable		 4ltwA-4am9A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl6 PROTEIN BICAUDAL D

(Drosophila
melanogaster) 		PF09730
(BicD) 		5 LEU A 719
LEU A 722
LEU A 725
ALA A 726
GLN A 729
 None
 0.55A 4ltwA-4bl6A:
undetectable		 4ltwA-4bl6A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 LEU A 484
LEU A 487
LEU A 490
ALA A 489
LEU A 434
 None
 1.20A 4ltwA-4bocA:
undetectable		 4ltwA-4bocA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyx FERRITIN HEAVY CHAIN

(Homo sapiens) 		PF00210
(Ferritin) 		5 LEU A 114
LEU A 117
LEU A 120
ALA A 121
LEU A  72
 None
 0.92A 4ltwA-4dyxA:
undetectable		 4ltwA-4dyxA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		5 LEU A  64
LEU A  60
LEU A  57
ALA A  58
LEU A  91
 None
 1.12A 4ltwA-4f3eA:
undetectable		 4ltwA-4f3eA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 LEU A 645
LEU A 648
LEU A 651
ALA A 652
LEU A 669
 None
 1.02A 4ltwA-4fddA:
undetectable		 4ltwA-4fddA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		6 LEU A 324
LEU A 327
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.12A 4ltwA-4fdhA:
undetectable		 4ltwA-4fdhA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia) 		PF00933
(Glyco_hydro_3) 		5 LEU A  35
ALA A  63
ARG A  54
LEU A  10
CYH A 284
 None
 1.09A 4ltwA-4g6cA:
undetectable		 4ltwA-4g6cA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica) 		PF00933
(Glyco_hydro_3) 		5 LEU A  31
ALA A  60
ARG A  50
LEU A   6
CYH A 279
 None
 1.05A 4ltwA-4gvfA:
undetectable		 4ltwA-4gvfA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)

(Candida
albicans) 		PF01965
(DJ-1_PfpI) 		5 LEU A  86
ASN A  85
LEU A  83
ALA A  82
LEU A   5
 None
 0.90A 4ltwA-4lruA:
undetectable		 4ltwA-4lruA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		7 LEU A 280
LEU A 283
LEU A 286
ALA A 287
MET A 321
ARG A 331
MET A 358
 None
 0.71A 4ltwA-4n1yA:
29.6		 4ltwA-4n1yA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 563
ASN A 564
LEU A 566
GLN A 570
MET A 601
ARG A 611
LEU A 732
CYH A 736
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
 0.55A 4ltwA-4p6wA:
36.6		 4ltwA-4p6wA:
62.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		5 LEU A 185
LEU A 157
ASN A 158
ALA A 159
LEU A 167
 None
 1.12A 4ltwA-4perA:
undetectable		 4ltwA-4perA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwv P450 MONOOXYGENASE

(Streptomyces
sp. Acta 2897) 		PF00067
(p450) 		5 LEU A 172
LEU A 175
ASN A 176
ALA A 179
LEU A 200
 None
 0.96A 4ltwA-4pwvA:
2.7		 4ltwA-4pwvA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		5 LEU A 501
LEU A 498
ASN A 497
LEU A 495
ALA A 494
 None
 1.18A 4ltwA-4qmkA:
undetectable		 4ltwA-4qmkA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 LEU A 172
LEU A 204
LEU A 205
ALA A 206
ARG A 134
 None
 1.10A 4ltwA-4u33A:
undetectable		 4ltwA-4u33A:
15.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 766
LEU A 769
ASN A 770
LEU A 772
ALA A 773
GLN A 776
MET A 807
ARG A 817
LEU A 938
CYH A 942
 CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
 0.40A 4ltwA-4udbA:
36.1		 4ltwA-4udbA:
65.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uie SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 5 LEU A 786
ASN A 789
LEU A 787
ALA A 788
LEU A 774
 None
 1.11A 4ltwA-4uieA:
undetectable		 4ltwA-4uieA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj8 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 5 LEU A 786
ASN A 789
LEU A 787
ALA A 788
LEU A 774
 None
 1.19A 4ltwA-4uj8A:
undetectable		 4ltwA-4uj8A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		5 LEU A 773
ASN A 774
LEU A 776
ALA A 777
LEU A 820
 None
 0.88A 4ltwA-4uvkA:
undetectable		 4ltwA-4uvkA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9s PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
sp. Mg1) 		PF00977
(His_biosynth) 		5 LEU A 204
LEU A 207
LEU A 210
ALA A 211
LEU A 238
 None
 0.91A 4ltwA-4x9sA:
undetectable		 4ltwA-4x9sA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 LEU A 132
LEU A  54
ASN A  55
LEU A  81
ALA A  80
 None
 1.06A 4ltwA-4xmvA:
undetectable		 4ltwA-4xmvA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5f BACTERIOPHYTOCHROME

(Deinococcus
radiodurans) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 LEU A  69
LEU A  42
LEU A  41
ALA A  40
LEU A 103
 None
 1.12A 4ltwA-4y5fA:
undetectable		 4ltwA-4y5fA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		5 LEU A 286
LEU A 283
ASN A 282
LEU A 280
ALA A 279
 None
 0.97A 4ltwA-5ddbA:
undetectable		 4ltwA-5ddbA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE

(Escherichia
coli) 		PF02574
(S-methyl_trans) 		5 LEU A 245
LEU A 242
LEU A 239
ALA A 238
LEU A 203
 None
 1.09A 4ltwA-5dmnA:
undetectable		 4ltwA-5dmnA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		5 LEU A  56
LEU A  59
LEU A  62
MET A 285
CYH A 325
 None
 1.17A 4ltwA-5dpdA:
undetectable		 4ltwA-5dpdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Aspergillus
fumigatus) 		PF02358
(Trehalose_PPase) 		5 LEU A  46
LEU A  49
LEU A  52
ALA A  53
LEU A  83
 None
 0.88A 4ltwA-5dxlA:
undetectable		 4ltwA-5dxlA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpr DNA LIGASE

(Staphylococcus
aureus) 		PF01653
(DNA_ligase_aden) 		5 LEU A 242
LEU A 239
LEU A 236
ALA A 235
GLN A 232
 None
 1.20A 4ltwA-5fprA:
undetectable		 4ltwA-5fprA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF12341
(Mcl1_mid) 		5 LEU A 812
LEU A 815
ALA A 816
MET A 788
LEU A 795
 None
 0.90A 4ltwA-5gvbA:
undetectable		 4ltwA-5gvbA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF11864
(DUF3384) 		5 LEU A 251
LEU A 254
LEU A 257
ALA A 256
LEU A 281
 LEU  A 251 ( 0.5A)
LEU  A 254 ( 0.6A)
LEU  A 257 ( 0.6A)
ALA  A 256 ( 0.0A)
LEU  A 281 ( 0.6A)
 1.19A 4ltwA-5hiuA:
undetectable		 4ltwA-5hiuA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgx PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8

(Homo sapiens) 		PF00254
(FKBP_C)
PF07719
(TPR_2) 		5 LEU E 275
ASN E 276
LEU E 278
ALA E 279
GLN E 282
 None
 0.57A 4ltwA-5mgxE:
undetectable		 4ltwA-5mgxE:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 11 LEU A 766
LEU A 769
ASN A 770
LEU A 772
ALA A 773
GLN A 776
MET A 807
ARG A 817
MET A 845
LEU A 938
CYH A 942
 ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
 0.44A 4ltwA-5mwpA:
38.0		 4ltwA-5mwpA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1t COPC

(Thioalkalivibrio
paradoxus) 		no annotation 5 LEU M  52
LEU M  55
ASN M  56
LEU M  58
ALA M  59
 None
 0.71A 4ltwA-5n1tM:
undetectable		 4ltwA-5n1tM:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 256
LEU A 259
ASN A 260
LEU A 262
ARG A  26
 None
 1.16A 4ltwA-5o0jA:
undetectable		 4ltwA-5o0jA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 5 LEU C 421
LEU C 388
LEU C 352
ALA C 353
LEU C 426
 None
 1.15A 4ltwA-5o4gC:
undetectable		 4ltwA-5o4gC:
17.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 298
LEU A 301
ALA A 302
MET A 336
ARG A 346
 EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 ( 3.9A)
EST  A 601 ( 3.7A)
EST  A 601 (-4.1A)
 0.36A 4ltwA-5toaA:
27.2		 4ltwA-5toaA:
31.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
ASN A 560
LEU A 562
GLN A 566
ARG A 607
MET A 635
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
486  A 801 (-3.5A)
486  A 801 ( 4.7A)
 1.02A 4ltwA-5uc1A:
25.2		 4ltwA-5uc1A:
61.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
ASN A 560
LEU A 562
GLN A 566
MET A 597
ARG A 607
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
 0.81A 4ltwA-5uc1A:
25.2		 4ltwA-5uc1A:
61.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  32
ASN A  33
LEU A  35
GLN A  39
ARG A  80
MET A 108
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
 0.88A 4ltwA-5ufsA:
38.4		 4ltwA-5ufsA:
73.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
LEU A 201
CYH A 205
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.8A)
1TA  A 301 (-3.6A)
 0.46A 4ltwA-5ufsA:
38.4		 4ltwA-5ufsA:
73.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE

(Escherichia
coli) 		no annotation 5 LEU A  91
LEU A 115
LEU A 116
ALA A 117
LEU A  83
 None
 1.09A 4ltwA-5z03A:
undetectable		 4ltwA-5z03A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5

(Aquareovirus C) 		no annotation 5 LEU B 514
ASN B 515
LEU B 517
ALA B 518
LEU B 582
 None
 1.02A 4ltwA-5zvtB:
undetectable		 4ltwA-5zvtB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 5 LEU K 610
LEU K 613
ASN K 614
LEU K 616
ALA K 617
 None
 0.91A 4ltwA-6d6qK:
undetectable		 4ltwA-6d6qK:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3d ARGININOSUCCINATE
LYASE

(Chelativorans
sp. BNC1) 		no annotation 5 LEU A 249
LEU A 252
LEU A 255
ALA A 256
LEU A  25
 None
 1.01A 4ltwA-6g3dA:
undetectable		 4ltwA-6g3dA:
18.85