SIMILAR PATTERNS OF AMINO ACIDS FOR 4LTW_A_STRA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 LEU A 244
ASN A 245
LEU A 248
GLN A 252
LEU A  61
 None
 0.99A 4ltwA-1g8kA:
undetectable		 4ltwA-1g8kA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdf SPHERULIN 3A

(Physarum
polycephalum) 		PF08964
(Crystall_3) 		5 LEU A  82
ASN A  88
LEU A  87
ALA A  90
MET A  94
 None
CA  A1101 ( 4.6A)
None
CA  A1102 (-4.4A)
None
 1.08A 4ltwA-1hdfA:
undetectable		 4ltwA-1hdfA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU C 422
LEU C 389
LEU C 353
ALA C 354
LEU C 427
 None
 1.10A 4ltwA-1n8yC:
undetectable		 4ltwA-1n8yC:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
LEU A 349
ALA A 350
ARG A 394
MET A 421
 EST  A   1 (-4.4A)
EST  A   1 ( 4.8A)
EST  A   1 ( 3.7A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
 0.53A 4ltwA-1pcgA:
28.5		 4ltwA-1pcgA:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		5 LEU A 755
LEU A 756
LEU A 760
ALA A 764
LEU A 749
 None
 1.15A 4ltwA-1qu2A:
undetectable		 4ltwA-1qu2A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qx8 REGULATORY PROTEIN
ROP

(Escherichia
coli) 		PF01815
(Rop) 		5 LEU A  23
LEU A  26
ASN A  27
LEU A  29
ALA A  30
 None
 0.44A 4ltwA-1qx8A:
undetectable		 4ltwA-1qx8A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC

(Shigella
flexneri) 		PF03932
(CutC) 		5 LEU A 131
LEU A 134
ASN A 135
LEU A 137
ALA A 138
 None
 0.76A 4ltwA-1twdA:
undetectable		 4ltwA-1twdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		5 LEU A  83
LEU A  69
LEU A  72
ALA A  73
GLN A  76
 None
 0.89A 4ltwA-1x9sA:
undetectable		 4ltwA-1x9sA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkp CHAPERONE PROTEIN
SYCN

(Yersinia pestis) 		no annotation 5 LEU B  50
ALA B 109
GLN B 108
MET B  31
LEU B  15
 None
 1.15A 4ltwA-1xkpB:
undetectable		 4ltwA-1xkpB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		5 LEU A  36
LEU A  33
LEU A  61
ALA A  30
GLN A  27
 None
 1.10A 4ltwA-1xviA:
undetectable		 4ltwA-1xviA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		5 LEU A 233
LEU A 232
ALA A 231
GLN A 104
LEU A 217
 None
 1.19A 4ltwA-1ycnA:
undetectable		 4ltwA-1ycnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yo7 REGULATORY PROTEIN
ROP

(Escherichia
coli) 		PF01815
(Rop) 		5 LEU A 111
LEU A 114
ASN A 115
LEU A 117
ALA A 118
 None
 0.90A 4ltwA-1yo7A:
undetectable		 4ltwA-1yo7A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvk HYPOTHETICAL PROTEIN
BSU33890

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		5 LEU A  18
LEU A  21
LEU A  24
ALA A  25
LEU A  84
 None
None
None
COA  A 201 (-3.6A)
None
 1.16A 4ltwA-1yvkA:
undetectable		 4ltwA-1yvkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		5 LEU A 691
LEU A 694
LEU A 697
ALA A 698
LEU A 257
 None
 1.03A 4ltwA-2a3lA:
undetectable		 4ltwA-2a3lA:
17.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 701
LEU A 704
ASN A 705
LEU A 707
GLN A 711
MET A 742
ARG A 752
MET A 780
LEU A 873
 None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-4.4A)
 0.69A 4ltwA-2ax9A:
36.1		 4ltwA-2ax9A:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 701
LEU A 704
LEU A 707
GLN A 711
MET A 742
MET A 749
ARG A 752
MET A 780
LEU A 873
 None
BHM  A   1 (-4.0A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-4.4A)
 0.83A 4ltwA-2ax9A:
36.1		 4ltwA-2ax9A:
60.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
GAMMA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 LEU E 457
LEU E 460
LEU E 463
ALA E 464
CYH E 229
 None
 1.07A 4ltwA-2bg9E:
undetectable		 4ltwA-2bg9E:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bku IMPORTIN BETA-1
SUBUNIT

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 LEU B 199
LEU B 202
ASN B 203
LEU B 205
ALA B 206
 None
 0.70A 4ltwA-2bkuB:
undetectable		 4ltwA-2bkuB:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4p HYPOTHETICAL PROTEIN
TTHA1254

(Thermus
thermophilus) 		PF09390
(DUF1999) 		5 LEU A  11
LEU A  14
ASN A  15
LEU A  17
ALA A  18
 None
 0.98A 4ltwA-2d4pA:
undetectable		 4ltwA-2d4pA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef0 ORNITHINE
CARBAMOYLTRANSFERASE

(Thermus
thermophilus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  23
LEU A  26
LEU A  29
ALA A  30
LEU A 136
 None
 0.80A 4ltwA-2ef0A:
undetectable		 4ltwA-2ef0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 265
LEU A 268
LEU A 271
ALA A 272
MET A 306
ARG A 316
 None
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
 0.40A 4ltwA-2gpvA:
26.4		 4ltwA-2gpvA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 271
LEU A 268
LEU A 265
ALA A 264
LEU A 324
 OHT  A 500 ( 4.4A)
OHT  A 500 (-4.1A)
None
None
None
 1.20A 4ltwA-2gpvA:
26.4		 4ltwA-2gpvA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 LEU A 556
LEU A 559
LEU A 562
ALA A 563
MET A  61
 None
 0.76A 4ltwA-2h4tA:
2.2		 4ltwA-2h4tA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		5 LEU A 134
LEU A 131
LEU A 127
ALA A 126
LEU A  91
 None
 1.17A 4ltwA-2i5bA:
undetectable		 4ltwA-2i5bA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4b TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT
72/90-100 KDA

(Encephalitozoon
cuniculi) 		PF04494
(TFIID_NTD2) 		5 LEU A 134
LEU A 137
ASN A 138
LEU A 141
MET A 113
 None
 0.95A 4ltwA-2j4bA:
undetectable		 4ltwA-2j4bA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5e UNCHARACTERIZED
PROTEIN

(Methanocaldococcus
jannaschii) 		PF08984
(DUF1858) 		6 LEU A  58
LEU A  61
ASN A  62
LEU A  64
ALA A  65
MET A   9
 None
 1.24A 4ltwA-2k5eA:
undetectable		 4ltwA-2k5eA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o42 M11L PROTEIN

(Myxoma virus) 		PF11099
(M11L) 		5 LEU A  81
LEU A  84
LEU A  87
ALA A  88
LEU A  27
 None
 1.12A 4ltwA-2o42A:
undetectable		 4ltwA-2o42A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6r VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A  82
LEU A 106
LEU A 130
ALA A 129
LEU A 101
 None
 1.11A 4ltwA-2o6rA:
undetectable		 4ltwA-2o6rA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
LEU A 349
ALA A 350
ARG A 394
MET A 421
 EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
EST  A 596 ( 3.9A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
 0.50A 4ltwA-2ocfA:
29.6		 4ltwA-2ocfA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 145
LEU A 146
ALA A 333
MET A 291
LEU A 374
 None
 1.00A 4ltwA-2ppgA:
undetectable		 4ltwA-2ppgA:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		11 LEU A  29
LEU A  32
ASN A  33
LEU A  35
ALA A  36
GLN A  39
MET A  70
ARG A  80
MET A 108
LEU A 201
CYH A 205
 1CA  A 247 ( 3.6A)
1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
1CA  A 247 ( 4.2A)
1CA  A 247 (-4.0A)
 0.23A 4ltwA-2q3yA:
40.6		 4ltwA-2q3yA:
90.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc3 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		5 LEU A 168
LEU A 171
LEU A 174
ALA A 175
LEU A 187
 None
 1.12A 4ltwA-2qc3A:
undetectable		 4ltwA-2qc3A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgh DIAMINOPIMELATE
DECARBOXYLASE

(Helicobacter
pylori) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A  51
LEU A  54
LEU A  57
ALA A  58
LEU A  76
 None
 0.89A 4ltwA-2qghA:
undetectable		 4ltwA-2qghA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmx PREPHENATE
DEHYDRATASE

(Chlorobaculum
tepidum) 		PF00800
(PDT) 		5 LEU A 262
ASN A 261
LEU A 259
ALA A 258
LEU A 215
 None
 0.84A 4ltwA-2qmxA:
undetectable		 4ltwA-2qmxA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		6 LEU A 372
LEU A 375
LEU A 378
ALA A 379
GLN A 382
LEU A 521
 None
 1.09A 4ltwA-2qveA:
undetectable		 4ltwA-2qveA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z55 ARCHAERHODOPSIN-2

(Halobacterium
sp. AUS-2) 		PF01036
(Bac_rhodopsin) 		5 LEU A  99
LEU A 102
LEU A 105
ALA A 106
LEU A 158
 None
 0.63A 4ltwA-2z55A:
undetectable		 4ltwA-2z55A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beh MLL3241 PROTEIN

(Mesorhizobium
loti) 		PF07885
(Ion_trans_2) 		5 LEU A 109
LEU A 106
LEU A  80
ALA A  81
LEU A  22
 None
 1.19A 4ltwA-3behA:
undetectable		 4ltwA-3behA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		no annotation 5 LEU B 970
LEU B 973
LEU B 976
ALA B 977
LEU B 938
 None
 0.83A 4ltwA-3cqcB:
undetectable		 4ltwA-3cqcB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE

(Corynebacterium
diphtheriae) 		PF12897
(Aminotran_MocR) 		5 LEU A 290
ASN A 291
LEU A 293
ALA A 294
GLN A 297
 None
 0.76A 4ltwA-3d6kA:
undetectable		 4ltwA-3d6kA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis) 		PF05163
(DinB) 		5 LEU A  78
ASN A  79
LEU A  81
ALA A  82
LEU A 135
 None
 0.92A 4ltwA-3dkaA:
undetectable		 4ltwA-3dkaA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LEU A1021
ASN A1024
LEU A1022
ALA A1023
LEU A1110
 None
 1.11A 4ltwA-3eh1A:
undetectable		 4ltwA-3eh1A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA

(Escherichia
coli) 		PF06144
(DNA_pol3_delta)
PF14840
(DNA_pol3_delt_C) 		5 LEU A 236
LEU A 233
LEU A 230
ALA A 229
LEU A 250
 None
 1.18A 4ltwA-3glgA:
undetectable		 4ltwA-3glgA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 LEU A  36
LEU A 150
ALA A 151
GLN A 155
LEU A  28
 None
 1.03A 4ltwA-3hd8A:
undetectable		 4ltwA-3hd8A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4r NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		PF03177
(Nucleoporin_C) 		5 LEU B 970
LEU B 973
LEU B 976
ALA B 977
LEU B 938
 None
 0.81A 4ltwA-3i4rB:
undetectable		 4ltwA-3i4rB:
16.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 715
ASN A 719
LEU A 721
GLN A 725
MET A 756
ARG A 766
LEU A 887
CYH A 891
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
 0.61A 4ltwA-3kbaA:
36.7		 4ltwA-3kbaA:
66.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 715
LEU A 718
ASN A 719
LEU A 721
MET A 756
ARG A 766
LEU A 887
CYH A 891
 WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
 0.37A 4ltwA-3kbaA:
36.7		 4ltwA-3kbaA:
66.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kux PUTATIVE
OXIDOREDUCTASE

(Yersinia pestis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A 343
LEU A 195
ASN A 196
LEU A 216
LEU A 199
 None
 1.20A 4ltwA-3kuxA:
undetectable		 4ltwA-3kuxA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 5 LEU X 564
LEU X 561
LEU X 512
ALA X 511
LEU X 235
 None
 0.93A 4ltwA-3kvnX:
undetectable		 4ltwA-3kvnX:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		5 LEU A 138
LEU A 141
LEU A 144
ALA A 145
MET A 164
 None
 1.01A 4ltwA-3l6aA:
undetectable		 4ltwA-3l6aA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2b DIAMINOPIMELATE
DECARBOXYLASE

(Vibrio cholerae) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A  66
LEU A  69
ASN A  70
LEU A  72
ALA A  73
 None
 1.10A 4ltwA-3n2bA:
undetectable		 4ltwA-3n2bA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odp PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Clostridium
novyi) 		PF01380
(SIS) 		5 LEU A 353
ASN A 354
LEU A 352
ALA A 355
LEU A   5
 None
 1.17A 4ltwA-3odpA:
undetectable		 4ltwA-3odpA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 LEU N  79
LEU N  82
LEU N  85
ALA N  86
LEU N 463
 LFA  N 488 ( 4.8A)
None
None
None
None
 0.64A 4ltwA-3rkoN:
undetectable		 4ltwA-3rkoN:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
MET A 108
LEU A 201
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
 0.28A 4ltwA-3ry9A:
38.4		 4ltwA-3ry9A:
81.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
SUBUNIT D
V-TYPE ATP SYNTHASE
SUBUNIT F

(Thermus
thermophilus) 		PF01813
(ATP-synt_D)
PF01990
(ATP-synt_F) 		5 LEU H  71
LEU H  72
LEU G 137
MET G  47
LEU G 147
 None
 1.10A 4ltwA-3w3aH:
undetectable		 4ltwA-3w3aH:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnw FERRITIN HEAVY CHAIN

(Mus musculus) 		PF00210
(Ferritin) 		5 LEU A 114
LEU A 117
LEU A 120
ALA A 121
LEU A  72
 None
 0.96A 4ltwA-3wnwA:
undetectable		 4ltwA-3wnwA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvi TYPE-2 RESTRICTION
ENZYME HINDIII

(Haemophilus
influenzae) 		PF09518
(RE_HindIII) 		5 LEU A 180
LEU A 175
LEU A 172
ALA A 173
LEU A 230
 None
 1.05A 4ltwA-3wviA:
undetectable		 4ltwA-3wviA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am9 CHAPERONE SYCD

(Yersinia
enterocolitica) 		PF07720
(TPR_3) 		6 LEU A  36
LEU A  39
LEU A  42
ALA A  43
GLN A  46
CYH A  63
 None
 0.79A 4ltwA-4am9A:
undetectable		 4ltwA-4am9A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl6 PROTEIN BICAUDAL D

(Drosophila
melanogaster) 		PF09730
(BicD) 		5 LEU A 719
LEU A 722
LEU A 725
ALA A 726
GLN A 729
 None
 0.55A 4ltwA-4bl6A:
undetectable		 4ltwA-4bl6A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 LEU A 484
LEU A 487
LEU A 490
ALA A 489
LEU A 434
 None
 1.20A 4ltwA-4bocA:
undetectable		 4ltwA-4bocA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyx FERRITIN HEAVY CHAIN

(Homo sapiens) 		PF00210
(Ferritin) 		5 LEU A 114
LEU A 117
LEU A 120
ALA A 121
LEU A  72
 None
 0.92A 4ltwA-4dyxA:
undetectable		 4ltwA-4dyxA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		5 LEU A  64
LEU A  60
LEU A  57
ALA A  58
LEU A  91
 None
 1.12A 4ltwA-4f3eA:
undetectable		 4ltwA-4f3eA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 LEU A 645
LEU A 648
LEU A 651
ALA A 652
LEU A 669
 None
 1.02A 4ltwA-4fddA:
undetectable		 4ltwA-4fddA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		6 LEU A 324
LEU A 327
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.12A 4ltwA-4fdhA:
undetectable		 4ltwA-4fdhA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia) 		PF00933
(Glyco_hydro_3) 		5 LEU A  35
ALA A  63
ARG A  54
LEU A  10
CYH A 284
 None
 1.09A 4ltwA-4g6cA:
undetectable		 4ltwA-4g6cA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica) 		PF00933
(Glyco_hydro_3) 		5 LEU A  31
ALA A  60
ARG A  50
LEU A   6
CYH A 279
 None
 1.05A 4ltwA-4gvfA:
undetectable		 4ltwA-4gvfA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)

(Candida
albicans) 		PF01965
(DJ-1_PfpI) 		5 LEU A  86
ASN A  85
LEU A  83
ALA A  82
LEU A   5
 None
 0.90A 4ltwA-4lruA:
undetectable		 4ltwA-4lruA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		7 LEU A 280
LEU A 283
LEU A 286
ALA A 287
MET A 321
ARG A 331
MET A 358
 None
 0.71A 4ltwA-4n1yA:
29.6		 4ltwA-4n1yA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 563
ASN A 564
LEU A 566
GLN A 570
MET A 601
ARG A 611
LEU A 732
CYH A 736
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
 0.55A 4ltwA-4p6wA:
36.6		 4ltwA-4p6wA:
62.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		5 LEU A 185
LEU A 157
ASN A 158
ALA A 159
LEU A 167
 None
 1.12A 4ltwA-4perA:
undetectable		 4ltwA-4perA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwv P450 MONOOXYGENASE

(Streptomyces
sp. Acta 2897) 		PF00067
(p450) 		5 LEU A 172
LEU A 175
ASN A 176
ALA A 179
LEU A 200
 None
 0.96A 4ltwA-4pwvA:
2.7		 4ltwA-4pwvA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		5 LEU A 501
LEU A 498
ASN A 497
LEU A 495
ALA A 494
 None
 1.18A 4ltwA-4qmkA:
undetectable		 4ltwA-4qmkA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 LEU A 172
LEU A 204
LEU A 205
ALA A 206
ARG A 134
 None
 1.10A 4ltwA-4u33A:
undetectable		 4ltwA-4u33A:
15.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 766
LEU A 769
ASN A 770
LEU A 772
ALA A 773
GLN A 776
MET A 807
ARG A 817
LEU A 938
CYH A 942
 CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
 0.40A 4ltwA-4udbA:
36.1		 4ltwA-4udbA:
65.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uie SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 5 LEU A 786
ASN A 789
LEU A 787
ALA A 788
LEU A 774
 None
 1.11A 4ltwA-4uieA:
undetectable		 4ltwA-4uieA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj8 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 5 LEU A 786
ASN A 789
LEU A 787
ALA A 788
LEU A 774
 None
 1.19A 4ltwA-4uj8A:
undetectable		 4ltwA-4uj8A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		5 LEU A 773
ASN A 774
LEU A 776
ALA A 777
LEU A 820
 None
 0.88A 4ltwA-4uvkA:
undetectable		 4ltwA-4uvkA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9s PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
sp. Mg1) 		PF00977
(His_biosynth) 		5 LEU A 204
LEU A 207
LEU A 210
ALA A 211
LEU A 238
 None
 0.91A 4ltwA-4x9sA:
undetectable		 4ltwA-4x9sA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 LEU A 132
LEU A  54
ASN A  55
LEU A  81
ALA A  80
 None
 1.06A 4ltwA-4xmvA:
undetectable		 4ltwA-4xmvA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5f BACTERIOPHYTOCHROME

(Deinococcus
radiodurans) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 LEU A  69
LEU A  42
LEU A  41
ALA A  40
LEU A 103
 None
 1.12A 4ltwA-4y5fA:
undetectable		 4ltwA-4y5fA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		5 LEU A 286
LEU A 283
ASN A 282
LEU A 280
ALA A 279
 None
 0.97A 4ltwA-5ddbA:
undetectable		 4ltwA-5ddbA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE

(Escherichia
coli) 		PF02574
(S-methyl_trans) 		5 LEU A 245
LEU A 242
LEU A 239
ALA A 238
LEU A 203
 None
 1.09A 4ltwA-5dmnA:
undetectable		 4ltwA-5dmnA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		5 LEU A  56
LEU A  59
LEU A  62
MET A 285
CYH A 325
 None
 1.17A 4ltwA-5dpdA:
undetectable		 4ltwA-5dpdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Aspergillus
fumigatus) 		PF02358
(Trehalose_PPase) 		5 LEU A  46
LEU A  49
LEU A  52
ALA A  53
LEU A  83
 None
 0.88A 4ltwA-5dxlA:
undetectable		 4ltwA-5dxlA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpr DNA LIGASE

(Staphylococcus
aureus) 		PF01653
(DNA_ligase_aden) 		5 LEU A 242
LEU A 239
LEU A 236
ALA A 235
GLN A 232
 None
 1.20A 4ltwA-5fprA:
undetectable		 4ltwA-5fprA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF12341
(Mcl1_mid) 		5 LEU A 812
LEU A 815
ALA A 816
MET A 788
LEU A 795
 None
 0.90A 4ltwA-5gvbA:
undetectable		 4ltwA-5gvbA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF11864
(DUF3384) 		5 LEU A 251
LEU A 254
LEU A 257
ALA A 256
LEU A 281
 LEU  A 251 ( 0.5A)
LEU  A 254 ( 0.6A)
LEU  A 257 ( 0.6A)
ALA  A 256 ( 0.0A)
LEU  A 281 ( 0.6A)
 1.19A 4ltwA-5hiuA:
undetectable		 4ltwA-5hiuA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgx PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8

(Homo sapiens) 		PF00254
(FKBP_C)
PF07719
(TPR_2) 		5 LEU E 275
ASN E 276
LEU E 278
ALA E 279
GLN E 282
 None
 0.57A 4ltwA-5mgxE:
undetectable		 4ltwA-5mgxE:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 11 LEU A 766
LEU A 769
ASN A 770
LEU A 772
ALA A 773
GLN A 776
MET A 807
ARG A 817
MET A 845
LEU A 938
CYH A 942
 ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
 0.44A 4ltwA-5mwpA:
38.0		 4ltwA-5mwpA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1t COPC

(Thioalkalivibrio
paradoxus) 		no annotation 5 LEU M  52
LEU M  55
ASN M  56
LEU M  58
ALA M  59
 None
 0.71A 4ltwA-5n1tM:
undetectable		 4ltwA-5n1tM:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 256
LEU A 259
ASN A 260
LEU A 262
ARG A  26
 None
 1.16A 4ltwA-5o0jA:
undetectable		 4ltwA-5o0jA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 5 LEU C 421
LEU C 388
LEU C 352
ALA C 353
LEU C 426
 None
 1.15A 4ltwA-5o4gC:
undetectable		 4ltwA-5o4gC:
17.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 298
LEU A 301
ALA A 302
MET A 336
ARG A 346
 EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 ( 3.9A)
EST  A 601 ( 3.7A)
EST  A 601 (-4.1A)
 0.36A 4ltwA-5toaA:
27.2		 4ltwA-5toaA:
31.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
ASN A 560
LEU A 562
GLN A 566
ARG A 607
MET A 635
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
486  A 801 (-3.5A)
486  A 801 ( 4.7A)
 1.02A 4ltwA-5uc1A:
25.2		 4ltwA-5uc1A:
61.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
ASN A 560
LEU A 562
GLN A 566
MET A 597
ARG A 607
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
 0.81A 4ltwA-5uc1A:
25.2		 4ltwA-5uc1A:
61.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  32
ASN A  33
LEU A  35
GLN A  39
ARG A  80
MET A 108
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
 0.88A 4ltwA-5ufsA:
38.4		 4ltwA-5ufsA:
73.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
LEU A 201
CYH A 205
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.8A)
1TA  A 301 (-3.6A)
 0.46A 4ltwA-5ufsA:
38.4		 4ltwA-5ufsA:
73.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE

(Escherichia
coli) 		no annotation 5 LEU A  91
LEU A 115
LEU A 116
ALA A 117
LEU A  83
 None
 1.09A 4ltwA-5z03A:
undetectable		 4ltwA-5z03A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5

(Aquareovirus C) 		no annotation 5 LEU B 514
ASN B 515
LEU B 517
ALA B 518
LEU B 582
 None
 1.02A 4ltwA-5zvtB:
undetectable		 4ltwA-5zvtB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 5 LEU K 610
LEU K 613
ASN K 614
LEU K 616
ALA K 617
 None
 0.91A 4ltwA-6d6qK:
undetectable		 4ltwA-6d6qK:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3d ARGININOSUCCINATE
LYASE

(Chelativorans
sp. BNC1) 		no annotation 5 LEU A 249
LEU A 252
LEU A 255
ALA A 256
LEU A  25
 None
 1.01A 4ltwA-6g3dA:
undetectable		 4ltwA-6g3dA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awc PROTEIN (GA BINDING
PROTEIN ALPHA)
PROTEIN (GA BINDING
PROTEIN BETA 1)

(Mus musculus) 		PF00178
(Ets)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 TRP B 110
THR A 331
VAL A 418
PHE B 136
 None
 0.96A 4ltwA-1awcB:
undetectable		 4ltwA-1awcB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ALA A 606
PHE A 570
THR A 538
PHE A 583
 None
 1.03A 4ltwA-1ciyA:
undetectable		 4ltwA-1ciyA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dly HEMOGLOBIN

(Chlamydomonas
moewusii) 		PF01152
(Bac_globin) 		4 ALA A  15
THR A 111
VAL A 115
PHE A  80
 None
HEM  A 144 ( 4.1A)
None
HEM  A 144 (-4.4A)
 0.77A 4ltwA-1dlyA:
undetectable		 4ltwA-1dlyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dml DNA POLYMERASE
PROCESSIVITY FACTOR

(Human
alphaherpesvirus
1) 		PF02282
(Herpes_UL42) 		4 ALA A 303
THR A 192
VAL A 212
PHE A 202
 None
 1.04A 4ltwA-1dmlA:
undetectable		 4ltwA-1dmlA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 MET A 172
THR A 532
VAL A 536
PHE A 540
 None
 0.87A 4ltwA-1fuiA:
undetectable		 4ltwA-1fuiA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2

(Mus musculus) 		PF09258
(Glyco_transf_64) 		4 MET A 249
ALA A 248
VAL A  99
PHE A 139
 None
 0.94A 4ltwA-1omxA:
undetectable		 4ltwA-1omxA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		4 ALA M 273
PHE M 150
THR M 133
PHE L 215
 BPH  M   5 (-4.2A)
BPH  M   5 (-3.7A)
BPH  M   5 ( 4.2A)
None
 1.00A 4ltwA-1pssM:
undetectable		 4ltwA-1pssM:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 ALA A  28
THR A  56
VAL A  44
PHE A  58
 None
 0.96A 4ltwA-1q3bA:
undetectable		 4ltwA-1q3bA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgi PROTEIN
(CHITOSANASE)

(Bacillus
circulans) 		PF01374
(Glyco_hydro_46) 		4 MET A 109
THR A 143
VAL A 147
PHE A  64
 None
 0.99A 4ltwA-1qgiA:
undetectable		 4ltwA-1qgiA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qx6 NPQTN SPECIFIC
SORTASE B

(Staphylococcus
aureus) 		PF04203
(Sortase) 		4 PHE A 195
THR A 199
VAL A 237
PHE A 170
 None
 0.93A 4ltwA-1qx6A:
undetectable		 4ltwA-1qx6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 ALA A 180
MET A 132
THR A 196
PHE A  29
 None
 1.04A 4ltwA-1rf5A:
undetectable		 4ltwA-1rf5A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Zea mays) 		PF00903
(Glyoxalase) 		4 ALA A 160
THR A  46
VAL A 270
PHE A 240
 None
 1.01A 4ltwA-1sp8A:
undetectable		 4ltwA-1sp8A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		4 TRP A 135
ALA A 108
VAL A 314
PHE A 315
 None
None
BOG  A 400 ( 4.0A)
None
 1.03A 4ltwA-1u7gA:
undetectable		 4ltwA-1u7gA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvx GLOBIN LI637

(Chlamydomonas
moewusii) 		PF01152
(Bac_globin) 		4 ALA A  15
THR A 111
VAL A 115
PHE A  80
 XE  A1127 ( 3.9A)
HEM  A1122 (-4.3A)
HEM  A1122 (-4.9A)
HEM  A1122 (-3.7A)
 0.74A 4ltwA-1uvxA:
undetectable		 4ltwA-1uvxA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkh PUTATIVE SERINE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF07859
(Abhydrolase_3) 		4 ALA A 122
MET A 137
PHE A 115
PHE A 174
 None
 1.03A 4ltwA-1vkhA:
undetectable		 4ltwA-1vkhA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Homo sapiens) 		PF01424
(R3H)
PF04857
(CAF1) 		4 MET A 328
ALA A 329
VAL A 360
PHE A  74
 None
 1.00A 4ltwA-2a1rA:
undetectable		 4ltwA-2a1rA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 745
MET A 787
PHE A 876
VAL A 889
PHE A 891
 BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
None
None
None
 0.86A 4ltwA-2ax9A:
36.1		 4ltwA-2ax9A:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 TRP A 741
MET A 787
PHE A 876
VAL A 889
PHE A 891
 None
BHM  A   1 (-3.6A)
None
None
None
 1.25A 4ltwA-2ax9A:
36.1		 4ltwA-2ax9A:
60.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		4 ALA A 373
THR A 459
VAL A  10
PHE A 461
 None
 0.95A 4ltwA-2e0pA:
undetectable		 4ltwA-2e0pA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Aquifex
aeolicus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 MET A 293
ALA A 304
MET A 179
VAL A 133
 None
 1.03A 4ltwA-2ebdA:
undetectable		 4ltwA-2ebdA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE

(Thermus
thermophilus) 		PF00596
(Aldolase_II) 		4 ALA A 153
MET A 173
PHE A  29
THR A  40
 None
 0.99A 4ltwA-2fk5A:
undetectable		 4ltwA-2fk5A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE

(Thermus
thermophilus) 		PF00596
(Aldolase_II) 		4 ALA A 153
PHE A  29
THR A  40
VAL A  44
 None
 0.96A 4ltwA-2fk5A:
undetectable		 4ltwA-2fk5A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0a TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF13377
(Peripla_BP_3) 		4 ALA A 285
PHE A  77
VAL A 197
PHE A 198
 None
 0.89A 4ltwA-2h0aA:
undetectable		 4ltwA-2h0aA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 TRP A  69
MET A  73
ALA A  74
MET A 115
PHE A 204
THR A 208
VAL A 217
PHE A 219
 None
1CA  A 247 (-3.6A)
1CA  A 247 ( 4.4A)
1CA  A 247 ( 3.7A)
1CA  A 247 (-4.7A)
1CA  A 247 (-3.4A)
None
1CA  A 247 (-4.5A)
 0.34A 4ltwA-2q3yA:
40.6		 4ltwA-2q3yA:
90.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qru UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF07859
(Abhydrolase_3) 		4 PHE A 212
THR A 214
VAL A 242
PHE A 249
 None
 1.00A 4ltwA-2qruA:
undetectable		 4ltwA-2qruA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1h HEMOGLOBIN SUBUNIT
ALPHA-4
HEMOGLOBIN SUBUNIT
BETA-4

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		4 TRP A  14
MET A  64
VAL B 112
PHE A 118
 None
 1.03A 4ltwA-2r1hA:
undetectable		 4ltwA-2r1hA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmh FIBRONECTIN TYPE III
DOMAIN PROTEIN

(Clostridium
perfringens) 		PF08305
(NPCBM) 		4 ALA A 918
THR A 975
VAL A1016
PHE A 973
 None
 1.03A 4ltwA-2vmhA:
undetectable		 4ltwA-2vmhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 TRP A 581
ALA A 700
THR A 470
VAL A 474
 None
 1.00A 4ltwA-2wghA:
undetectable		 4ltwA-2wghA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN

(Streptomyces
coelicolor) 		PF01497
(Peripla_BP_2) 		4 ALA A 293
THR A 141
VAL A 171
PHE A 143
 None
 1.02A 4ltwA-2x4lA:
undetectable		 4ltwA-2x4lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au0 CLUMPING FACTOR B

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		4 ALA A 334
THR A 393
VAL A 486
PHE A 395
 None
 1.04A 4ltwA-3au0A:
undetectable		 4ltwA-3au0A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b85 PHOSPHATE
STARVATION-INDUCIBLE
PROTEIN

(Corynebacterium
glutamicum) 		PF02562
(PhoH) 		4 ALA A 201
MET A 205
PHE A 237
VAL A 137
 SO4  A 409 ( 4.1A)
None
None
None
 1.04A 4ltwA-3b85A:
undetectable		 4ltwA-3b85A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT

(Methanosarcina
barkeri) 		PF02552
(CO_dh) 		4 ALA G  45
PHE G 151
THR G   4
VAL G   2
 ACY  A 819 ( 4.3A)
None
None
None
 0.95A 4ltwA-3cf4G:
undetectable		 4ltwA-3cf4G:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cny INOSITOL CATABOLISM
PROTEIN IOLE

(Lactobacillus
plantarum) 		PF01261
(AP_endonuc_2) 		4 MET A 285
ALA A 286
PHE A 216
THR A 190
 None
 0.90A 4ltwA-3cnyA:
undetectable		 4ltwA-3cnyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		4 MET A 321
ALA A 322
VAL A 353
PHE A  74
 None
 0.93A 4ltwA-3d45A:
undetectable		 4ltwA-3d45A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emq ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		4 MET A 263
ALA A 264
PHE A 313
THR A 298
 None
 0.99A 4ltwA-3emqA:
undetectable		 4ltwA-3emqA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa3 2,3-DIMETHYLMALATE
LYASE

(Aspergillus
niger) 		PF13714
(PEP_mutase) 		4 MET A 251
ALA A 249
PHE A 241
THR A  46
 None
None
None
OAF  A 501 (-3.3A)
 0.89A 4ltwA-3fa3A:
undetectable		 4ltwA-3fa3A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flj UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA WITH A
CYSTATIN-LIKE FOLD

(Ruegeria
pomeroyi) 		PF12680
(SnoaL_2) 		4 ALA A 120
PHE A  56
VAL A 103
PHE A  30
 None
 1.00A 4ltwA-3fljA:
undetectable		 4ltwA-3fljA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwr YQZB PROTEIN

(Bacillus
subtilis) 		PF00571
(CBS) 		4 ALA A 167
THR A 110
VAL A 123
PHE A 112
 None
ADP  A 221 ( 3.9A)
None
None
 0.97A 4ltwA-3fwrA:
undetectable		 4ltwA-3fwrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 ALA A 867
PHE A 903
VAL A 671
PHE A 673
 None
 0.95A 4ltwA-3hmjA:
undetectable		 4ltwA-3hmjA:
8.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 759
MET A 801
THR A 894
VAL A 903
PHE A 905
 WOW  A   1 (-3.7A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
None
WOW  A   1 (-4.6A)
 0.59A 4ltwA-3kbaA:
36.7		 4ltwA-3kbaA:
66.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 TRP A 755
MET A 801
THR A 894
VAL A 903
PHE A 905
 None
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
None
WOW  A   1 (-4.6A)
 1.01A 4ltwA-3kbaA:
36.7		 4ltwA-3kbaA:
66.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Sulfolobus
solfataricus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ALA A 199
MET A 217
THR A  61
VAL A 146
 None
 0.96A 4ltwA-3l7zA:
undetectable		 4ltwA-3l7zA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pow CALRETICULIN

(Homo sapiens) 		PF00262
(Calreticulin) 		4 ALA A  76
MET A 122
VAL A  93
PHE A  95
 None
 1.04A 4ltwA-3powA:
undetectable		 4ltwA-3powA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg0 CALRETICULIN

(Mus musculus) 		PF00262
(Calreticulin) 		4 ALA A  76
MET A 122
VAL A  93
PHE A  95
 None
 1.00A 4ltwA-3rg0A:
undetectable		 4ltwA-3rg0A:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		8 TRP A  69
MET A  73
ALA A  74
MET A 115
PHE A 204
THR A 208
VAL A 217
PHE A 219
 None
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.7A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.8A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.9A)
1CA  A 249 (-4.3A)
 0.51A 4ltwA-3ry9A:
38.4		 4ltwA-3ry9A:
81.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		4 MET A 441
ALA A 442
PHE A 614
PHE A 642
 None
 1.01A 4ltwA-4a0hA:
undetectable		 4ltwA-4a0hA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anf ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC

(Mycoplasma
penetrans) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ALA A 226
PHE A 162
THR A 174
PHE A 145
 None
 1.04A 4ltwA-4anfA:
undetectable		 4ltwA-4anfA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1r MANNOSYL-6-PHOSPHATA
SE

(Bacteroides
thetaiotaomicron) 		PF03372
(Exo_endo_phos) 		4 MET A  58
ALA A  56
MET A  80
PHE A 237
 None
 0.99A 4ltwA-4c1rA:
undetectable		 4ltwA-4c1rA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4

(Homo sapiens) 		PF13561
(adh_short_C2) 		4 ALA B  19
THR B 114
VAL B  63
PHE B  67
 None
 1.00A 4ltwA-4cqmB:
undetectable		 4ltwA-4cqmB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5v PUTATIVE THUA-LIKE
PROTEIN

(Parabacteroides
merdae) 		PF06283
(ThuA) 		4 PHE A 265
THR A 245
VAL A 113
PHE A 243
 None
 0.96A 4ltwA-4e5vA:
undetectable		 4ltwA-4e5vA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A)
PF11934
(DUF3452) 		4 MET A 148
ALA A 147
THR A  77
VAL A  81
 None
 1.02A 4ltwA-4eljA:
undetectable		 4ltwA-4eljA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 ALA A 113
THR A 333
VAL A 337
PHE A 319
 None
 0.97A 4ltwA-4gfjA:
undetectable		 4ltwA-4gfjA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7h EVAA 2,3-DEHYDRATASE

(Amycolatopsis
orientalis) 		PF03559
(Hexose_dehydrat) 		4 MET A 229
ALA A 226
THR A 443
VAL A 449
 None
 0.97A 4ltwA-4j7hA:
undetectable		 4ltwA-4j7hA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7k CATION EFFLUX SYSTEM
PROTEIN CUSC

(Escherichia
coli) 		PF02321
(OEP) 		4 ALA A 129
THR A  64
VAL A 144
PHE A 119
 None
 1.00A 4ltwA-4k7kA:
undetectable		 4ltwA-4k7kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF02128
(Peptidase_M36) 		4 MET A 465
ALA A 466
PHE A 395
THR A 397
 None
 1.00A 4ltwA-4k90A:
undetectable		 4ltwA-4k90A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ALA A 153
MET A 156
THR A 172
VAL A 145
 None
 0.90A 4ltwA-4kbfA:
undetectable		 4ltwA-4kbfA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kva SEPTIN

(Schistosoma
mansoni) 		PF00735
(Septin) 		4 MET A 169
ALA A 168
THR A 157
PHE A 196
 None
 0.65A 4ltwA-4kvaA:
undetectable		 4ltwA-4kvaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3w LIPASE

(Rhizopus
microsporus) 		PF01764
(Lipase_3) 		4 ALA A  99
THR A  53
VAL A  59
PHE A  93
 None
 0.80A 4ltwA-4l3wA:
undetectable		 4ltwA-4l3wA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		4 ALA A 461
PHE A 935
THR A1013
VAL A 942
 None
 1.02A 4ltwA-4mt1A:
undetectable		 4ltwA-4mt1A:
13.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		4 TRP A 320
PHE A 450
VAL A 460
PHE A 462
 None
 0.60A 4ltwA-4n1yA:
29.6		 4ltwA-4n1yA:
31.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 MET A 816
ALA A 817
MET A 873
THR A 948
 None
 0.92A 4ltwA-4nmeA:
undetectable		 4ltwA-4nmeA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqr CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 ALA A 271
THR A 129
VAL A 153
PHE A 149
 None
 0.81A 4ltwA-4oqrA:
2.4		 4ltwA-4oqrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqs CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 ALA A 271
THR A 129
VAL A 153
PHE A 149
 None
 0.80A 4ltwA-4oqsA:
3.2		 4ltwA-4oqsA:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 TRP A 600
ALA A 605
MET A 646
THR A 739
PHE A 749
 None
MOF  A 801 ( 4.8A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 0.75A 4ltwA-4p6wA:
36.6		 4ltwA-4p6wA:
62.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 TRP A 600
MET A 604
ALA A 605
MET A 646
PHE A 749
 None
None
MOF  A 801 ( 4.8A)
MOF  A 801 (-4.4A)
MOF  A 801 (-4.4A)
 0.87A 4ltwA-4p6wA:
36.6		 4ltwA-4p6wA:
62.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE

(Brucella
abortus) 		PF01370
(Epimerase) 		4 ALA A 298
THR A  19
VAL A   8
PHE A  75
 None
 1.01A 4ltwA-4twrA:
undetectable		 4ltwA-4twrA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		4 MET A 269
ALA A 267
MET A 339
THR A 242
 None
 0.97A 4ltwA-4u33A:
undetectable		 4ltwA-4u33A:
15.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 TRP A 806
MET A 852
PHE A 941
THR A 945
VAL A 954
PHE A 956
 None
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.6A)
CV7  A1987 (-3.1A)
None
CV7  A1987 ( 4.7A)
 0.48A 4ltwA-4udbA:
36.1		 4ltwA-4udbA:
65.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2i ESTERASE/LIPASE

(Thalassospira
sp. GB04J01) 		PF07859
(Abhydrolase_3) 		4 ALA A 107
THR A 135
VAL A 167
PHE A  83
 None
 1.02A 4ltwA-4v2iA:
undetectable		 4ltwA-4v2iA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN

(Thielavia
terrestris) 		PF07470
(Glyco_hydro_88) 		4 ALA A 181
PHE A 252
THR A 256
PHE A 200
 None
 1.00A 4ltwA-4xuvA:
undetectable		 4ltwA-4xuvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 ALA A 178
THR A 230
VAL A 234
PHE A 224
 CA  A 503 ( 4.5A)
None
None
None
 0.96A 4ltwA-4yweA:
undetectable		 4ltwA-4yweA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 MET A 205
ALA A 206
PHE A 312
THR A 299
 None
 1.03A 4ltwA-5a4jA:
undetectable		 4ltwA-5a4jA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 MET A 204
ALA A 205
PHE A 311
THR A 298
 None
 0.97A 4ltwA-5a5gA:
undetectable		 4ltwA-5a5gA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn7 MALTODEXTRIN
GLUCOSIDASE

(Escherichia
coli) 		PF00128
(Alpha-amylase) 		4 ALA A 405
THR A 472
VAL A 555
PHE A 544
 None
 0.92A 4ltwA-5bn7A:
undetectable		 4ltwA-5bn7A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		4 ALA A 495
MET A 447
THR A 511
PHE A 343
 None
 0.99A 4ltwA-5bs5A:
undetectable		 4ltwA-5bs5A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		4 PHE A 627
THR A 625
VAL A 676
PHE A 611
 None
 0.99A 4ltwA-5cjuA:
undetectable		 4ltwA-5cjuA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1p PTMO8

(Streptomyces
platensis) 		PF13561
(adh_short_C2) 		4 ALA A  78
MET A  74
THR A  22
VAL A 226
 None
 1.04A 4ltwA-5f1pA:
undetectable		 4ltwA-5f1pA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 MET A 448
ALA A 449
VAL A  74
PHE A 100
 None
None
None
EDO  A1873 ( 4.0A)
 0.86A 4ltwA-5fjiA:
undetectable		 4ltwA-5fjiA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 MET A 448
ALA A 449
VAL A  75
PHE A 100
 None
 0.98A 4ltwA-5fjjA:
undetectable		 4ltwA-5fjjA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxf ACRYLYL-COA
REDUCTASE ACUI

(Ruegeria
pomeroyi) 		PF00107
(ADH_zinc_N) 		4 MET A 293
PHE A 132
THR A  89
VAL A 113
 None
 1.02A 4ltwA-5gxfA:
undetectable		 4ltwA-5gxfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 ALA A 113
THR A 333
VAL A 337
PHE A 319
 None
 1.01A 4ltwA-5hm5A:
undetectable		 4ltwA-5hm5A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)

(Parageobacillus
thermoglucosidasius) 		PF00171
(Aldedh) 		4 MET A 180
ALA A 177
THR A 440
VAL A 455
 None
 0.99A 4ltwA-5j78A:
undetectable		 4ltwA-5j78A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 MET A 166
ALA A 165
PHE A 289
THR A 102
 None
 1.00A 4ltwA-5jd4A:
undetectable		 4ltwA-5jd4A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 MET A 209
ALA A 211
VAL A 283
PHE A 261
 None
 0.98A 4ltwA-5macA:
undetectable		 4ltwA-5macA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlh -

(-) 		no annotation 4 ALA A 382
PHE A 207
VAL A 347
PHE A 343
 None
None
XOG  A 402 (-3.6A)
NAP  A 404 ( 4.8A)
 1.01A 4ltwA-5mlhA:
undetectable		 4ltwA-5mlhA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 TRP A 806
PHE A 941
THR A 945
VAL A 954
PHE A 956
 None
ECV  A1101 (-4.3A)
ECV  A1101 (-3.2A)
None
ECV  A1101 ( 4.7A)
 0.44A 4ltwA-5mwpA:
38.0		 4ltwA-5mwpA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 TRP A 581
ALA A 700
THR A 470
VAL A 474
 None
 0.99A 4ltwA-5tusA:
undetectable		 4ltwA-5tusA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uah RNA POLYMERASE SIGMA
FACTOR RPOD

(Escherichia
coli) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04546
(Sigma70_ner) 		4 MET F 322
ALA F 321
PHE F 316
PHE F 306
 None
 0.96A 4ltwA-5uahF:
undetectable		 4ltwA-5uahF:
16.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 4 TRP A 596
MET A 600
ALA A 601
MET A 642
 None
None
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
 0.41A 4ltwA-5uc1A:
25.2		 4ltwA-5uc1A:
61.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 TRP A  69
ALA A  74
MET A 115
PHE A 204
THR A 208
VAL A 216
PHE A 218
 None
1TA  A 301 ( 3.7A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.7A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.3A)
1TA  A 301 (-4.0A)
 0.62A 4ltwA-5ufsA:
38.4		 4ltwA-5ufsA:
73.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 TRP A  69
MET A  73
ALA A  74
MET A 115
THR A 208
VAL A 216
PHE A 218
 None
1TA  A 301 (-4.2A)
1TA  A 301 ( 3.7A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.3A)
1TA  A 301 (-4.0A)
 0.68A 4ltwA-5ufsA:
38.4		 4ltwA-5ufsA:
73.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugj 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Neisseria
meningitidis) 		no annotation 4 ALA A 241
MET A  15
THR A 167
PHE A 134
 None
 1.03A 4ltwA-5ugjA:
undetectable		 4ltwA-5ugjA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans) 		PF03639
(Glyco_hydro_81) 		4 PHE A 306
THR A 304
VAL A 269
PHE A 184
 None
None
EDO  A 815 (-4.4A)
None
 1.03A 4ltwA-5v1wA:
undetectable		 4ltwA-5v1wA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 4 MET A 246
ALA A 247
THR A 616
VAL A 612
 None
 0.86A 4ltwA-5v9xA:
undetectable		 4ltwA-5v9xA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xkt UREASE ACCESSORY
PROTEIN UREG

(Klebsiella
pneumoniae) 		no annotation 4 MET A  31
ALA A  30
THR A 180
PHE A 147
 None
 0.80A 4ltwA-5xktA:
undetectable		 4ltwA-5xktA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygk -

(-) 		no annotation 4 ALA A  52
PHE A  36
VAL A  45
PHE A 115
 None
 0.84A 4ltwA-5ygkA:
undetectable		 4ltwA-5ygkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1

(Danio rerio) 		no annotation 4 PHE A 208
THR A 189
VAL A 315
PHE A 311
 None
None
None
ACT  A 603 ( 4.4A)
 0.89A 4ltwA-6b82A:
2.0		 4ltwA-6b82A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 4 ALA A 313
MET A 333
VAL A 421
PHE A 423
 None
 0.86A 4ltwA-6chjA:
undetectable		 4ltwA-6chjA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g47 FIBER-1

(Human
mastadenovirus
G) 		no annotation 4 ALA A 332
PHE A 253
VAL A 232
PHE A 357
 None
 0.94A 4ltwA-6g47A:
undetectable		 4ltwA-6g47A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 4 ALA A 401
PHE A 356
THR A 349
PHE A 474
 None
 0.69A 4ltwA-6gneA:
undetectable		 4ltwA-6gneA:
undetectable