SIMILAR PATTERNS OF AMINO ACIDS FOR 4LTW_A_486A303_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atg PERIPLASMIC
MOLYBDATE-BINDING
PROTEIN

(Azotobacter
vinelandii) 		PF13531
(SBP_bac_11) 		5 LEU A  15
ALA A  19
LEU A   3
GLN A 209
PHE A 210
 None
 1.35A 4ltwA-1atgA:
0.0		 4ltwA-1atgA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5l INTERFERON TAU

(Komagataella
pastoris) 		PF00143
(Interferon) 		5 THR A 156
LEU A 152
ALA A  11
LEU A  17
LEU A  61
 None
 1.43A 4ltwA-1b5lA:
undetectable		 4ltwA-1b5lA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)

(Thermotoga
maritima) 		PF00121
(TIM) 		5 THR A 203
LEU A 195
ALA A 160
LEU A 126
PHE A 152
 None
 1.38A 4ltwA-1b9bA:
undetectable		 4ltwA-1b9bA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H

(Streptomyces
plicatus) 		PF00704
(Glyco_hydro_18) 		5 ALA A  37
LEU A 262
PHE A 258
THR A 243
LEU A 246
 ALA  A  37 ( 0.0A)
LEU  A 262 ( 0.6A)
PHE  A 258 ( 1.3A)
THR  A 243 ( 0.8A)
LEU  A 246 ( 0.6A)
 1.34A 4ltwA-1c8xA:
undetectable		 4ltwA-1c8xA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9w CHO REDUCTASE

(Cricetulus
griseus) 		PF00248
(Aldo_ket_red) 		5 THR A   8
LEU A   6
ALA A 155
GLN A 183
THR A 205
 None
None
None
NAP  A 350 (-4.6A)
None
 1.19A 4ltwA-1c9wA:
undetectable		 4ltwA-1c9wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 THR A 241
LEU A 270
LEU A 448
GLN A 454
LEU A 282
 None
 1.34A 4ltwA-1dgjA:
undetectable		 4ltwA-1dgjA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyw PHOSPHOTRIESTERASE

(Brevundimonas
diminuta) 		PF02126
(PTE) 		5 LEU A 237
ALA A 286
LEU A 252
TYR A 292
THR A 241
 None
 1.44A 4ltwA-1eywA:
undetectable		 4ltwA-1eywA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ib1 SEROTONIN
N-ACETYLTRANSFERASE

(Ovis aries) 		PF00583
(Acetyltransf_1) 		5 LEU E 144
ALA E 156
GLN E 169
PHE E 173
TYR E 168
 None
None
None
None
COT  E 401 (-4.8A)
 1.42A 4ltwA-1ib1E:
undetectable		 4ltwA-1ib1E:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujn DEHYDROQUINATE
SYNTHASE

(Thermus
thermophilus) 		PF01761
(DHQ_synthase) 		5 LEU A 171
LEU A 164
PHE A 167
THR A 120
LEU A 203
 None
 1.30A 4ltwA-1ujnA:
undetectable		 4ltwA-1ujnA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN

(Thermus
thermophilus) 		PF10432
(bact-PGI_C) 		5 THR A 159
LEU A 160
ALA A 242
LEU A 221
THR A 265
 None
 1.32A 4ltwA-1wiwA:
0.0		 4ltwA-1wiwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wve 4-CRESOL
DEHYDROGENASE
[HYDROXYLATING]
FLAVOPROTEIN SUBUNIT

(Pseudomonas
putida) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 LEU A 238
ALA A 126
GLN A 136
TYR A 140
LEU A 146
 None
 1.22A 4ltwA-1wveA:
undetectable		 4ltwA-1wveA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls ORPHAN NUCLEAR
RECEPTOR NR1I3

(Mus musculus) 		PF00104
(Hormone_recep) 		5 LEU E 189
LEU E 203
GLN E 295
PHE E 278
LEU E 123
 None
 1.35A 4ltwA-1xlsE:
20.0		 4ltwA-1xlsE:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		5 LEU A 502
LEU A 531
PHE A 530
THR A 506
LEU A 507
 None
 1.36A 4ltwA-1ygpA:
undetectable		 4ltwA-1ygpA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yox HYPOTHETICAL PROTEIN
PA3696

(Pseudomonas
aeruginosa) 		PF01987
(AIM24) 		5 THR A 124
LEU A 149
ALA A 120
LEU A 118
PHE A 117
 None
 1.38A 4ltwA-1yoxA:
undetectable		 4ltwA-1yoxA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypz H2-T22 PROTEIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 THR A  80
LEU A  81
GLN A  99
TYR A   9
LEU A  78
 None
 1.37A 4ltwA-1ypzA:
undetectable		 4ltwA-1ypzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrz XYLAN
BETA-1,4-XYLOSIDASE

(Bacillus
halodurans) 		PF04616
(Glyco_hydro_43) 		5 ALA A1400
LEU A1359
PHE A1518
THR A1387
LEU A1454
 None
 1.39A 4ltwA-1yrzA:
undetectable		 4ltwA-1yrzA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		5 THR A 553
LEU A 591
GLN A 645
PHE A 646
THR A 648
 None
None
GAL  A 700 (-4.0A)
None
None
 1.21A 4ltwA-1z45A:
undetectable		 4ltwA-1z45A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzn GMP REDUCTASE 2

(Homo sapiens) 		PF00478
(IMPDH) 		5 THR A  74
LEU A  99
ALA A  64
GLN A  91
PHE A  88
 None
 1.27A 4ltwA-2bznA:
undetectable		 4ltwA-2bznA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d68 FOP

(Homo sapiens) 		PF09398
(FOP_dimer) 		5 ALA A  75
LEU A  82
PHE A  94
THR A  98
LEU A  62
 None
 1.36A 4ltwA-2d68A:
undetectable		 4ltwA-2d68A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dam ETEA PROTEIN

(Homo sapiens) 		PF14555
(UBA_4) 		5 ALA A  51
GLN A  24
PHE A  25
THR A  29
LEU A  56
 None
 1.43A 4ltwA-2damA:
undetectable		 4ltwA-2damA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 THR A 449
LEU A 433
ALA A 419
LEU A 397
PHE A 412
 None
 1.32A 4ltwA-2e7zA:
1.2		 4ltwA-2e7zA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG) 		PF05199
(GMC_oxred_C) 		5 THR A 595
ALA A 598
LEU A 198
TYR A  61
THR A  60
 FAD  A1625 (-3.4A)
None
None
None
None
 1.38A 4ltwA-2f5vA:
undetectable		 4ltwA-2f5vA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 THR A 156
LEU A 358
ALA A 159
LEU A 220
PHE A 383
 None
 1.41A 4ltwA-2h4tA:
2.2		 4ltwA-2h4tA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jr7 DPH3 HOMOLOG

(Homo sapiens) 		PF05207
(zf-CSL) 		5 ALA A  46
GLN A  14
PHE A  13
TYR A  22
LEU A  39
 None
 1.32A 4ltwA-2jr7A:
undetectable		 4ltwA-2jr7A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER
ATP-BINDING PROTEIN
HI1470

(Haemophilus
influenzae) 		PF00005
(ABC_tran) 		5 ALA C 196
LEU C 171
PHE C 184
THR C 186
LEU C  37
 None
 1.30A 4ltwA-2nq2C:
undetectable		 4ltwA-2nq2C:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER
ATP-BINDING PROTEIN
HI1470

(Haemophilus
influenzae) 		PF00005
(ABC_tran) 		5 THR C 199
ALA C 196
LEU C 171
PHE C 184
THR C 186
 None
 1.35A 4ltwA-2nq2C:
undetectable		 4ltwA-2nq2C:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER
ATP-BINDING PROTEIN
HI1470

(Haemophilus
influenzae) 		PF00005
(ABC_tran) 		5 THR C 212
ALA C 196
LEU C 171
PHE C 184
LEU C  37
 None
 1.40A 4ltwA-2nq2C:
undetectable		 4ltwA-2nq2C:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pan GLYOXYLATE
CARBOLIGASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 LEU A 200
LEU A 326
GLN A 225
PHE A 226
THR A 230
LEU A 342
 None
 1.32A 4ltwA-2panA:
undetectable		 4ltwA-2panA:
18.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		9 THR A  25
LEU A  29
ALA A 107
LEU A 111
GLN A 203
PHE A 204
TYR A 207
THR A 208
LEU A 215
 None
1CA  A 247 ( 3.6A)
GOL  A 248 (-4.5A)
None
None
1CA  A 247 (-4.7A)
None
1CA  A 247 (-3.4A)
None
 0.49A 4ltwA-2q3yA:
40.6		 4ltwA-2q3yA:
90.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qru UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF07859
(Abhydrolase_3) 		5 THR A 204
LEU A 205
LEU A 125
TYR A 106
THR A 132
 None
 1.36A 4ltwA-2qruA:
undetectable		 4ltwA-2qruA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		5 ALA A 376
LEU A 374
TYR A 295
THR A 297
LEU A 300
 None
 1.40A 4ltwA-2xdfA:
undetectable		 4ltwA-2xdfA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		5 THR A 225
LEU A 228
ALA A 193
GLN A 163
LEU A 238
 None
 1.29A 4ltwA-3a05A:
undetectable		 4ltwA-3a05A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		5 LEU A 490
ALA A 493
LEU A 501
TYR A 537
THR A 526
 None
 1.36A 4ltwA-3apoA:
undetectable		 4ltwA-3apoA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 THR A 308
LEU A 305
GLN A 295
PHE A 294
LEU A 281
 None
 1.28A 4ltwA-3b2dA:
undetectable		 4ltwA-3b2dA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cex UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF04978
(DUF664) 		5 LEU A 108
ALA A  14
GLN A 158
THR A  48
LEU A  52
 None
 1.40A 4ltwA-3cexA:
undetectable		 4ltwA-3cexA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjw COUP TRANSCRIPTION
FACTOR 2

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 245
ALA A 227
LEU A 236
THR A 248
LEU A 252
 None
 1.38A 4ltwA-3cjwA:
15.4		 4ltwA-3cjwA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpr DIHYDRODIPICOLINATE
SYNTHETASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		5 THR A   9
LEU A 208
LEU A 227
PHE A 215
TYR A 197
 None
 1.38A 4ltwA-3cprA:
undetectable		 4ltwA-3cprA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		5 LEU A  85
LEU A  69
GLN A  57
TYR A  56
LEU A  31
 None
 1.14A 4ltwA-3iehA:
undetectable		 4ltwA-3iehA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqx TAIL-ANCHORED
PROTEIN TARGETING
FACTOR GET3

(Chaetomium
thermophilum) 		PF02374
(ArsA_ATPase) 		5 THR A 163
LEU A 167
GLN A 227
PHE A 228
LEU A 257
 None
 1.30A 4ltwA-3iqxA:
undetectable		 4ltwA-3iqxA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbr GLUTAMINE
CYCLOTRANSFERASE

(Xanthomonas
campestris) 		PF05096
(Glu_cyclase_2) 		5 LEU X 227
LEU X 184
GLN X  28
TYR X  30
LEU X 212
 None
 1.12A 4ltwA-3mbrX:
undetectable		 4ltwA-3mbrX:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na8 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00701
(DHDPS) 		5 THR A  68
LEU A 272
ALA A 229
LEU A 264
THR A 275
 None
 1.22A 4ltwA-3na8A:
undetectable		 4ltwA-3na8A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 THR A 503
LEU A 499
ALA A 449
GLN A 443
LEU A 474
 None
 1.29A 4ltwA-3oeeA:
undetectable		 4ltwA-3oeeA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1w RABGDI PROTEIN

(Plasmodium
falciparum) 		PF00996
(GDI) 		5 LEU A 140
ALA A 134
PHE A 192
THR A 189
LEU A 185
 None
 1.38A 4ltwA-3p1wA:
undetectable		 4ltwA-3p1wA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pov ORF 37

(Human
gammaherpesvirus
8) 		PF01771
(Herpes_alk_exo) 		5 LEU A 453
ALA A 456
GLN A 376
PHE A 148
TYR A 375
 None
 1.40A 4ltwA-3povA:
undetectable		 4ltwA-3povA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		5 THR A  30
LEU A  31
LEU A  79
GLN A 133
THR A 139
 None
None
None
3HC  A 310 (-3.4A)
None
 1.45A 4ltwA-3pvtA:
2.1		 4ltwA-3pvtA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qld MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 THR A 240
LEU A 238
LEU A 231
TYR A 200
LEU A 211
 None
 1.38A 4ltwA-3qldA:
undetectable		 4ltwA-3qldA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj8 CARBOHYDRATE OXIDASE

(Microdochium
nivale) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 THR A 414
LEU A 406
GLN A 387
PHE A 388
LEU A 326
 None
 1.30A 4ltwA-3rj8A:
undetectable		 4ltwA-3rj8A:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		8 THR A  25
LEU A  29
LEU A 111
GLN A 203
PHE A 204
TYR A 207
THR A 208
LEU A 215
 None
1CA  A 249 ( 3.8A)
None
None
1CA  A 249 (-4.8A)
None
1CA  A 249 (-3.2A)
None
 0.49A 4ltwA-3ry9A:
38.4		 4ltwA-3ry9A:
81.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umb DEHALOGENASE-LIKE
HYDROLASE

(Ralstonia
solanacearum) 		PF00702
(Hydrolase) 		5 THR A 194
LEU A 176
ALA A 213
GLN A 224
PHE A 225
 None
 1.40A 4ltwA-3umbA:
undetectable		 4ltwA-3umbA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		5 LEU A 449
ALA A 357
GLN A 289
THR A 291
LEU A 293
 None
 1.37A 4ltwA-3v94A:
undetectable		 4ltwA-3v94A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		5 THR A 141
LEU A 154
ALA A  50
LEU A  63
GLN A  65
 None
 1.30A 4ltwA-3welA:
undetectable		 4ltwA-3welA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		5 THR A 163
LEU A  84
ALA A  75
LEU A 108
PHE A  86
 None
 1.39A 4ltwA-3wrtA:
undetectable		 4ltwA-3wrtA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		5 ALA A  53
GLN A   5
PHE A   6
TYR A   9
THR A  10
 None
 1.35A 4ltwA-4f62A:
undetectable		 4ltwA-4f62A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gul PIRIN

(Homo sapiens) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		5 LEU A 116
LEU A  36
PHE A 193
TYR A 195
LEU A 114
 None
 1.41A 4ltwA-4gulA:
undetectable		 4ltwA-4gulA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j80 CHAPERONE PROTEIN
DNAJ 2

(Thermus
thermophilus) 		PF00226
(DnaJ)
PF01556
(DnaJ_C) 		5 LEU A 242
ALA A 188
LEU A 190
THR A 207
LEU A 208
 None
 1.30A 4ltwA-4j80A:
undetectable		 4ltwA-4j80A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		5 LEU A 265
ALA A 269
GLN A 277
PHE A 278
LEU A 243
 None
 1.25A 4ltwA-4kv7A:
undetectable		 4ltwA-4kv7A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio cholerae) 		PF01135
(PCMT) 		5 LEU A  96
ALA A  26
LEU A  24
THR A  68
LEU A  93
 None
 1.40A 4ltwA-4l7vA:
undetectable		 4ltwA-4l7vA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhu 9C2 TCR GAMMA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 THR G  73
LEU G  83
LEU G  66
GLN G  48
TYR G  39
 None
 1.44A 4ltwA-4lhuG:
undetectable		 4ltwA-4lhuG:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN

(Escherichia
coli) 		PF00989
(PAS) 		5 THR C 130
ALA C 117
LEU C  78
THR C 178
LEU C 175
 None
 1.44A 4ltwA-4lryC:
undetectable		 4ltwA-4lryC:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lws UNCHARACTERIZED
PROTEIN

(Thermomonospora
curvata) 		PF06013
(WXG100) 		5 THR A  80
LEU A  77
ALA B  48
LEU B  41
TYR B  55
 None
None
None
None
ACT  B 103 ( 4.9A)
 1.25A 4ltwA-4lwsA:
undetectable		 4ltwA-4lwsA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mj7 RRNA-PROCESSING
PROTEIN UTP23

(Saccharomyces
cerevisiae) 		PF04900
(Fcf1) 		5 LEU A  49
ALA A 120
LEU A 141
THR A  52
LEU A  53
 None
 1.34A 4ltwA-4mj7A:
undetectable		 4ltwA-4mj7A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY

(Yersinia
frederiksenii) 		PF01758
(SBF) 		5 LEU A 251
ALA A  66
PHE A 243
THR A 247
LEU A 121
 None
 1.35A 4ltwA-4n7wA:
undetectable		 4ltwA-4n7wA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9q FMN-DEPENDENT
NADH-AZOREDUCTASE 1

(Pseudomonas
aeruginosa) 		PF02525
(Flavodoxin_2) 		5 THR A 180
LEU A 141
LEU A 206
TYR A  29
LEU A  90
 None
 1.39A 4ltwA-4n9qA:
undetectable		 4ltwA-4n9qA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 LEU A 117
ALA A  68
TYR A  62
THR A 115
LEU A  39
 None
 1.29A 4ltwA-4nbqA:
undetectable		 4ltwA-4nbqA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qla JUVENILE HORMONE
EPOXIDE HYDROLASE

(Bombyx mori) 		PF06441
(EHN) 		5 LEU A 386
ALA A 203
LEU A  33
PHE A 239
THR A 238
 None
 1.22A 4ltwA-4qlaA:
undetectable		 4ltwA-4qlaA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)

(Agrobacterium
fabrum) 		PF01547
(SBP_bac_1) 		5 THR A 226
LEU A 230
GLN A 245
PHE A 189
LEU A 388
 None
 1.45A 4ltwA-4rjzA:
undetectable		 4ltwA-4rjzA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		5 LEU A 222
LEU A  61
PHE A 351
THR A 240
LEU A 243
 None
 1.20A 4ltwA-4rxeA:
1.9		 4ltwA-4rxeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6h PROTEIN L1

(Vaccinia virus) 		PF02442
(L1R_F9L) 		5 THR E  75
LEU E  14
ALA E  72
GLN E 165
THR E 167
 None
 1.23A 4ltwA-4u6hE:
undetectable		 4ltwA-4u6hE:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 766
LEU A 848
PHE A 941
TYR A 944
THR A 945
LEU A 952
 CV7  A1987 (-3.6A)
CV7  A1987 ( 4.4A)
CV7  A1987 (-4.6A)
None
CV7  A1987 (-3.1A)
None
 0.51A 4ltwA-4udbA:
36.1		 4ltwA-4udbA:
65.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wen K88 FIMBRIAL PROTEIN
AC

(Escherichia
coli) 		PF02432
(Fimbrial_K88) 		5 THR A  65
LEU A 185
ALA A 225
LEU A 147
THR A 179
 None
 1.42A 4ltwA-4wenA:
undetectable		 4ltwA-4wenA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
BETA

(Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY) 		6 LEU B 230
ALA B 151
LEU B 107
PHE B 153
THR B 226
LEU B 213
 None
 1.49A 4ltwA-4wvmB:
undetectable		 4ltwA-4wvmB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y21 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		5 THR A 366
LEU A 367
ALA A 303
LEU A 277
LEU A 359
 None
 1.41A 4ltwA-4y21A:
undetectable		 4ltwA-4y21A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5f BACTERIOPHYTOCHROME

(Deinococcus
radiodurans) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 THR A 135
LEU A 301
ALA A 139
LEU A 308
THR A 168
 None
 1.26A 4ltwA-4y5fA:
undetectable		 4ltwA-4y5fA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 LEU A  52
ALA A 148
LEU A 390
PHE A 391
THR A  55
 None
 1.27A 4ltwA-4y9lA:
2.6		 4ltwA-4y9lA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt)
no annotation 		5 LEU B 222
LEU A  61
PHE B 351
THR B 240
LEU B 243
 None
 1.22A 4ltwA-5ahuB:
undetectable		 4ltwA-5ahuB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl6 PUTATIVE PORIN FOR
VANILLATE
TRAFFICKING (VANP)

(Acinetobacter
baumannii) 		PF03573
(OprD) 		5 THR A 291
LEU A 288
LEU A 250
GLN A 270
PHE A 269
 None
 1.42A 4ltwA-5dl6A:
undetectable		 4ltwA-5dl6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnc AVH146

(Phytophthora
sojae) 		no annotation 5 THR A 392
LEU A 389
ALA A 407
LEU A 445
PHE A 411
 None
 1.38A 4ltwA-5gncA:
undetectable		 4ltwA-5gncA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 THR A 753
LEU A 693
ALA A 749
LEU A 678
TYR A 672
 None
 1.30A 4ltwA-5i2gA:
undetectable		 4ltwA-5i2gA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 THR A 331
LEU A  30
ALA A 335
LEU A  75
LEU A  20
 None
 1.25A 4ltwA-5iq0A:
undetectable		 4ltwA-5iq0A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbp GLYCOSYL HYDROLASE,
FAMILY 38

(Enterococcus
faecalis) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 LEU A 142
GLN A  54
PHE A  86
TYR A 122
LEU A 120
 None
 1.39A 4ltwA-5kbpA:
undetectable		 4ltwA-5kbpA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum) 		PF02353
(CMAS) 		5 LEU A  62
LEU A 214
GLN A 272
PHE A 271
TYR A 270
 None
 1.39A 4ltwA-5kpgA:
undetectable		 4ltwA-5kpgA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N)
PF06444
(NADH_dehy_S2_C) 		5 THR M 134
LEU M 130
LEU N 248
TYR N 291
LEU M 147
 None
 1.33A 4ltwA-5lc5M:
undetectable		 4ltwA-5lc5M:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 THR X   9
LEU X   7
ALA X 156
GLN X 184
THR X 206
 None
None
MLZ  X 155 ( 3.0A)
NAP  X 401 (-3.8A)
EDO  X 403 (-4.6A)
 1.27A 4ltwA-5liyX:
undetectable		 4ltwA-5liyX:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 LEU A 766
ALA A 844
LEU A 848
PHE A 941
TYR A 944
THR A 945
LEU A 952
 ECV  A1101 ( 3.9A)
None
None
ECV  A1101 (-4.3A)
None
ECV  A1101 (-3.2A)
None
 0.47A 4ltwA-5mwpA:
38.0		 4ltwA-5mwpA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans) 		PF03568
(Peptidase_C50) 		5 THR 1 354
ALA 1 342
TYR 1  70
THR 1  67
LEU 1 384
 None
 1.34A 4ltwA-5mz61:
undetectable		 4ltwA-5mz61:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans) 		PF03568
(Peptidase_C50) 		5 THR 1 354
LEU 1 339
ALA 1 342
TYR 1  70
THR 1  67
 None
 1.44A 4ltwA-5mz61:
undetectable		 4ltwA-5mz61:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		5 THR A 270
LEU A 333
PHE A 360
TYR A 314
LEU A 275
 None
 1.32A 4ltwA-5n6mA:
undetectable		 4ltwA-5n6mA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria) 		no annotation 5 LEU A 374
ALA A 351
LEU A 359
GLN A 313
THR A 311
 None
 1.17A 4ltwA-5o3wA:
undetectable		 4ltwA-5o3wA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 5 ALA A 205
LEU A 365
GLN A 289
TYR A 200
LEU A 235
 9UB  A 803 ( 3.9A)
9UB  A 803 ( 4.1A)
9UB  A 803 (-2.8A)
None
None
 1.40A 4ltwA-5oglA:
undetectable		 4ltwA-5oglA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		5 THR A1298
LEU A1299
ALA A1235
LEU A1209
LEU A1291
 None
 1.45A 4ltwA-5ue8A:
undetectable		 4ltwA-5ue8A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4a P-GRANULE SCAFFOLD

(Caenorhabditis
japonica) 		no annotation 5 THR A 147
LEU A 144
ALA A  83
LEU A  81
LEU A 163
 None
 1.44A 4ltwA-5w4aA:
undetectable		 4ltwA-5w4aA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk0 DAMAGE-INDUCIBLE
PROTEIN DINB

(Staphylococcus
sp. HMSC055H04) 		no annotation 5 LEU A  56
ALA A 103
LEU A  14
PHE A  52
LEU A 125
 None
 1.40A 4ltwA-5wk0A:
undetectable		 4ltwA-5wk0A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN

(Rhodobacter
capsulatus) 		PF00005
(ABC_tran) 		5 ALA A 207
LEU A 183
PHE A 195
THR A 197
LEU A  37
 None
 1.42A 4ltwA-5x41A:
undetectable		 4ltwA-5x41A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0e -

(-) 		no annotation 5 LEU A 358
LEU A 387
PHE A 406
TYR A 405
THR A 404
 None
 1.43A 4ltwA-5y0eA:
undetectable		 4ltwA-5y0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zmy -

(-) 		no annotation 5 LEU A 234
LEU A 227
PHE A 209
THR A 189
LEU A 192
 None
 1.39A 4ltwA-5zmyA:
undetectable		 4ltwA-5zmyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a70 -

(-) 		no annotation 5 THR B3903
LEU B3907
ALA B3687
LEU B3995
THR B3948
 None
 1.15A 4ltwA-6a70B:
undetectable		 4ltwA-6a70B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 5 LEU A 711
ALA A 665
LEU A 735
TYR A 770
LEU A 707
 None
 1.38A 4ltwA-6d6yA:
undetectable		 4ltwA-6d6yA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Cyanidioschyzon
merolae) 		no annotation 5 THR A 512
ALA A 518
GLN A 142
TYR A 375
THR A 282
 None
 1.32A 4ltwA-6fosA:
undetectable		 4ltwA-6fosA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Cyanidioschyzon
merolae) 		no annotation 5 THR A 512
LEU A 278
ALA A 518
GLN A 142
TYR A 375
 None
 1.23A 4ltwA-6fosA:
undetectable		 4ltwA-6fosA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx6 -

(-) 		no annotation 5 THR A 162
LEU A 163
ALA A 139
LEU A 233
PHE A 141
 None
 1.26A 4ltwA-6fx6A:
undetectable		 4ltwA-6fx6A:
undetectable