SIMILAR PATTERNS OF AMINO ACIDS FOR 4LTW_A_486A302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqg D-GLUCARATE
DEHYDRATASE


(Pseudomonas
putida)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 LEU A 262
VAL A 226
LEU A 217
ILE A 223
ALA A 251
None
1.06A 4ltwA-1bqgA:
undetectable
4ltwA-1bqgA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Thermotoga
maritima)
PF01135
(PCMT)
5 VAL A 120
LEU A 102
ILE A 125
ILE A  25
ALA A  21
None
0.96A 4ltwA-1dl5A:
undetectable
4ltwA-1dl5A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)


(Penicillium
amagasakiense)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 LEU A  43
VAL A  39
ILE A  29
GLU A 288
ALA A 285
None
1.09A 4ltwA-1gpeA:
undetectable
4ltwA-1gpeA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE


(Weissella
confusa)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 LEU A  40
VAL A  36
ILE A  26
ILE A  24
ALA A  90
None
0.99A 4ltwA-1hyhA:
undetectable
4ltwA-1hyhA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmo HEPARIN COFACTOR II

(Homo sapiens)
PF00079
(Serpin)
5 LEU A 386
LEU A 457
MET A 471
ILE A 134
ILE A 139
None
1.09A 4ltwA-1jmoA:
undetectable
4ltwA-1jmoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF00465
(Fe-ADH)
5 LEU A  27
LEU A  99
ILE A  91
ILE A  89
ALA A 111
None
0.98A 4ltwA-1jpuA:
undetectable
4ltwA-1jpuA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)


(Homo sapiens)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
5 LEU A 166
ILE A 157
GLU A 172
ILE A 173
ALA A 176
None
0.93A 4ltwA-1qgrA:
undetectable
4ltwA-1qgrA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rr9 ATP-DEPENDENT
PROTEASE LA


(Escherichia
coli)
PF05362
(Lon_C)
5 LEU A 630
GLN A 597
MET A 634
ILE A 638
ALA A 641
None
1.06A 4ltwA-1rr9A:
undetectable
4ltwA-1rr9A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s35 SPECTRIN BETA CHAIN,
ERYTHROCYTE


(Homo sapiens)
PF00435
(Spectrin)
5 LEU A1153
VAL A1084
LEU A1100
ILE A1106
ILE A1110
None
SO4  A 301 ( 4.6A)
None
None
None
0.87A 4ltwA-1s35A:
undetectable
4ltwA-1s35A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF01039
(Carboxyl_trans)
5 LEU A1978
VAL A2003
ILE A1949
ILE A1936
ALA A1935
None
1.03A 4ltwA-1uyvA:
undetectable
4ltwA-1uyvA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE


(Escherichia
coli)
PF00171
(Aldedh)
5 LEU A 159
ILE A  74
GLU A 100
ILE A 101
ALA A 103
None
1.03A 4ltwA-1wnbA:
undetectable
4ltwA-1wnbA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE


(Sulfurisphaera
tokodaii)
PF00180
(Iso_dh)
5 LEU A  54
GLN A   8
ILE A   7
ILE A  62
ALA A  65
None
0.91A 4ltwA-1wpwA:
undetectable
4ltwA-1wpwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 509
LEU A 350
GLN A 353
MET A 354
GLN A 358
ALA A 516
None
1.43A 4ltwA-1xb7A:
26.7
4ltwA-1xb7A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1


(Mus musculus)
PF00104
(Hormone_recep)
6 VAL A 278
GLN A 295
MET A 296
GLN A 300
GLU A 455
ALA A 459
None
0.99A 4ltwA-1yp0A:
22.8
4ltwA-1yp0A:
27.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 712
VAL A 716
GLN A 733
ILE A 737
MET A 894
GLU A 897
None
0.87A 4ltwA-2ax9A:
36.1
4ltwA-2ax9A:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 712
VAL A 716
GLN A 733
MET A 894
GLU A 897
ILE A 898
None
1.11A 4ltwA-2ax9A:
36.1
4ltwA-2ax9A:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 712
VAL A 716
LYS A 720
ILE A 737
MET A 894
GLU A 897
None
1.18A 4ltwA-2ax9A:
36.1
4ltwA-2ax9A:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 712
VAL A 716
LYS A 720
MET A 894
GLU A 897
ILE A 898
None
1.27A 4ltwA-2ax9A:
36.1
4ltwA-2ax9A:
60.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6


(Homo sapiens)
PF00017
(SH2)
PF00102
(Y_phosphatase)
5 VAL A 465
LEU A 251
ILE A 508
ILE A 512
ALA A 221
None
1.03A 4ltwA-2b3oA:
undetectable
4ltwA-2b3oA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dj6 HYPOTHETICAL PROTEIN
PH0634


(Pyrococcus
horikoshii)
PF01242
(PTPS)
5 LEU A  52
VAL A  56
LEU A 103
ILE A  88
ILE A  37
LEU  A  52 ( 0.6A)
VAL  A  56 ( 0.6A)
LEU  A 103 ( 0.6A)
ILE  A  88 ( 0.7A)
ILE  A  37 ( 0.7A)
1.05A 4ltwA-2dj6A:
undetectable
4ltwA-2dj6A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 276
LEU A 294
GLN A 297
MET A 298
GLN A 302
OHT  A 500 (-4.9A)
None
None
None
None
0.70A 4ltwA-2gpvA:
26.4
4ltwA-2gpvA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM


(Acinetobacter
sp. ADP1)
PF03466
(LysR_substrate)
5 LEU A 142
VAL A 273
ILE A 282
ILE A 285
ALA A 287
None
1.03A 4ltwA-2h98A:
undetectable
4ltwA-2h98A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT


(Escherichia
coli)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
6 VAL A 676
LEU A 702
GLN A 695
MET A 691
ILE A 684
ALA A 752
None
1.28A 4ltwA-2hnhA:
undetectable
4ltwA-2hnhA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9x PUTATIVE SEPTATION
PROTEIN SPOVG


(Staphylococcus
epidermidis)
PF04026
(SpoVG)
5 LEU A  34
VAL A  45
GLN A  70
ILE A  72
ILE A  23
None
1.09A 4ltwA-2i9xA:
undetectable
4ltwA-2i9xA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHL


(Pseudomonas
stutzeri)
PF02332
(Phenol_Hydrox)
5 VAL C 246
LEU C 126
ILE C 170
ILE C 174
ALA C 181
None
0.93A 4ltwA-2inpC:
undetectable
4ltwA-2inpC:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogi HYPOTHETICAL PROTEIN
SAG1661


(Streptococcus
agalactiae)
PF01966
(HD)
5 VAL A  33
LEU A 127
GLU A 164
ILE A 137
ALA A 160
None
1.09A 4ltwA-2ogiA:
undetectable
4ltwA-2ogiA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3e DIAMINOPIMELATE
DECARBOXYLASE


(Aquifex
aeolicus)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
5 LEU A 369
VAL A 295
ILE A 307
GLU A 361
ILE A 360
None
1.09A 4ltwA-2p3eA:
undetectable
4ltwA-2p3eA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR


(unidentified)
PF00104
(Hormone_recep)
7 VAL A  44
GLN A  61
ILE A  65
GLN A  66
MET A 222
GLU A 225
ILE A 226
None
0.97A 4ltwA-2q3yA:
40.6
4ltwA-2q3yA:
90.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR


(unidentified)
PF00104
(Hormone_recep)
7 VAL A  44
LEU A  58
GLN A  61
MET A  62
ILE A  65
GLN A  66
GLU A 225
None
0.82A 4ltwA-2q3yA:
40.6
4ltwA-2q3yA:
90.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvg KINESIN-2

(Giardia
intestinalis)
PF00225
(Kinesin)
5 LEU A 326
VAL A  39
ILE A  28
ILE A 312
ALA A 101
None
None
None
None
ADP  A1351 (-4.3A)
1.09A 4ltwA-2vvgA:
undetectable
4ltwA-2vvgA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvg KINESIN-2

(Giardia
intestinalis)
PF00225
(Kinesin)
5 LEU A 326
VAL A  39
LEU A  25
ILE A  28
ILE A 312
None
0.79A 4ltwA-2vvgA:
undetectable
4ltwA-2vvgA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w48 SORBITOL OPERON
REGULATOR


(Klebsiella
pneumoniae)
PF04198
(Sugar-bind)
PF13936
(HTH_38)
5 LEU A 179
ILE A 143
MET A 269
GLU A 268
ILE A 267
MPD  A1317 (-3.9A)
None
None
None
None
0.97A 4ltwA-2w48A:
undetectable
4ltwA-2w48A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE


(Mycolicibacterium
smegmatis)
PF02625
(XdhC_CoxI)
PF13478
(XdhC_C)
5 LEU A 295
VAL A 291
GLN A 263
ILE A 269
ALA A 268
None
1.04A 4ltwA-2we8A:
undetectable
4ltwA-2we8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1


(Drosophila
melanogaster)
PF00104
(Hormone_recep)
6 LEU A 841
VAL A 845
GLN A 862
MET A 863
GLN A 867
ALA A1023
None
0.63A 4ltwA-2xhsA:
19.9
4ltwA-2xhsA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1


(Drosophila
melanogaster)
PF00104
(Hormone_recep)
5 LEU A1016
GLN A 862
MET A 863
GLN A 867
ALA A1023
None
0.94A 4ltwA-2xhsA:
19.9
4ltwA-2xhsA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y30 PUTATIVE REPRESSOR
SIMREG2


(Streptomyces
antibioticus)
PF00440
(TetR_N)
PF02909
(TetR_C)
5 LEU A 117
VAL A  79
LEU A 133
ILE A  83
GLU A 165
None
0.89A 4ltwA-2y30A:
2.0
4ltwA-2y30A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE


(Aquifex
aeolicus)
PF00551
(Formyl_trans_N)
5 LEU A  15
VAL A   6
LEU A   2
ILE A  31
ILE A  19
None
0.98A 4ltwA-2ywrA:
undetectable
4ltwA-2ywrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Mus musculus)
PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD)
5 LEU A1268
MET A1172
GLU A1171
ILE A1170
ALA A1169
None
SAM  A   1 (-3.6A)
SAM  A   1 (-2.6A)
None
None
0.97A 4ltwA-3av6A:
undetectable
4ltwA-3av6A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efb PROBABLE SOR-OPERON
REGULATOR


(Shigella
flexneri)
PF04198
(Sugar-bind)
5 LEU A 129
ILE A  93
MET A 219
GLU A 218
ILE A 217
None
1.07A 4ltwA-3efbA:
undetectable
4ltwA-3efbA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd5 SELENIDE, WATER
DIKINASE 1


(Homo sapiens)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 LEU A 203
LEU A 328
ILE A 354
ILE A 271
ALA A 275
None
0.92A 4ltwA-3fd5A:
undetectable
4ltwA-3fd5A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi1 NA(+)/H(+)
ANTIPORTER NHAA


(Escherichia
coli)
PF06965
(Na_H_antiport_1)
5 LEU A 348
VAL A 224
ILE A 168
ILE A 345
ALA A 130
None
1.08A 4ltwA-3fi1A:
undetectable
4ltwA-3fi1A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9q FERRICHROME-BINDING
PROTEIN


(Bacillus
subtilis)
PF01497
(Peripla_BP_2)
5 LEU A 222
LEU A 302
GLN A 305
ILE A 309
ILE A 183
None
0.95A 4ltwA-3g9qA:
undetectable
4ltwA-3g9qA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM


(Acinetobacter
sp. ADP1)
PF03466
(LysR_substrate)
5 LEU A 142
VAL A 273
ILE A 282
ILE A 285
ALA A 287
None
1.03A 4ltwA-3glbA:
undetectable
4ltwA-3glbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqd OCTOPINE
DEHYDROGENASE


(Pecten maximus)
PF02317
(Octopine_DH)
5 LEU B 269
ILE B 205
MET B 261
ILE B 260
ALA B 344
None
0.99A 4ltwA-3iqdB:
undetectable
4ltwA-3iqdB:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 726
VAL A 730
GLN A 747
ILE A 751
MET A 908
ALA A 915
None
0.69A 4ltwA-3kbaA:
36.7
4ltwA-3kbaA:
66.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 VAL A 730
GLN A 747
ILE A 751
GLN A 752
ALA A 915
None
0.90A 4ltwA-3kbaA:
36.7
4ltwA-3kbaA:
66.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcm PUTATIVE
OXIDOREDUCTASE


(Streptococcus
mutans)
PF02525
(Flavodoxin_2)
5 LEU A  27
VAL A  23
ILE A   5
ILE A   3
ALA A  74
None
1.00A 4ltwA-3lcmA:
undetectable
4ltwA-3lcmA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS


(Aspergillus
oryzae)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 LEU A  26
VAL A  22
ILE A  12
GLU A 262
ALA A 259
None
1.00A 4ltwA-3q9tA:
undetectable
4ltwA-3q9tA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw4 UMP SYNTHASE

(Leishmania
donovani)
PF00156
(Pribosyltran)
PF00215
(OMPdecase)
5 LEU B 424
VAL B 401
LEU B 293
ILE B 288
ILE B 286
None
0.94A 4ltwA-3qw4B:
undetectable
4ltwA-3qw4B:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ta6 TRIOSEPHOSPHATE
ISOMERASE


(Mycobacterium
tuberculosis)
PF00121
(TIM)
5 LEU A 156
VAL A 130
LEU A   6
ILE A 169
ALA A 208
None
1.09A 4ltwA-3ta6A:
undetectable
4ltwA-3ta6A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE


(Coxiella
burnetii)
PF00551
(Formyl_trans_N)
5 LEU A  19
VAL A  10
LEU A   6
ILE A  34
ILE A  23
None
1.01A 4ltwA-3tqrA:
undetectable
4ltwA-3tqrA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1


(Arabidopsis
thaliana)
PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
5 LEU A  64
LEU A   4
GLU A  15
ILE A  14
ALA A  13
None
1.00A 4ltwA-3twkA:
undetectable
4ltwA-3twkA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx7 NUCLEAR RECEPTOR
SUBFAMILY 5 GROUP A
MEMBER 2


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU B 353
VAL B 357
GLN B 374
GLN B 379
GLU B 534
ALA B 538
None
0.52A 4ltwA-3tx7B:
19.4
4ltwA-3tx7B:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unv ADMH

(Pantoea
agglomerans)
PF00221
(Lyase_aromatic)
5 LEU A 347
LEU A  52
GLU A  39
ILE A  40
ALA A  43
None
0.99A 4ltwA-3unvA:
undetectable
4ltwA-3unvA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ups IOJAP-LIKE PROTEIN

(Zymomonas
mobilis)
PF02410
(RsfS)
5 LEU A  92
LEU A  22
ILE A 100
ILE A  99
ALA A  47
None
0.97A 4ltwA-3upsA:
undetectable
4ltwA-3upsA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B


(Enterococcus
hirae)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
5 LEU D 141
LEU D 304
ILE D 301
GLN D 300
ALA D 288
None
1.09A 4ltwA-3vr5D:
undetectable
4ltwA-3vr5D:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsk PENICILLIN-BINDING
PROTEIN 3


(Staphylococcus
aureus)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
5 LEU A 400
VAL A 579
ILE A 586
GLN A 590
ILE A 589
None
0.94A 4ltwA-3vskA:
undetectable
4ltwA-3vskA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07952
(Toxin_trans)
5 LEU A 590
VAL A 604
LEU A 583
ILE A 588
ILE A 768
None
1.03A 4ltwA-3zuqA:
undetectable
4ltwA-3zuqA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0t PUP--PROTEIN LIGASE

(Corynebacterium
glutamicum)
PF03136
(Pup_ligase)
5 LEU A 324
ILE A 158
GLU A 335
ILE A 334
ALA A 333
None
1.05A 4ltwA-4b0tA:
undetectable
4ltwA-4b0tA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvh ISOPRENOID SYNTHASE
DOMAIN-CONTAINING
PROTEIN


(Homo sapiens)
PF01128
(IspD)
6 LEU A 134
VAL A  50
LEU A 167
ILE A 154
ILE A 222
ALA A 179
None
1.25A 4ltwA-4cvhA:
undetectable
4ltwA-4cvhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d86 POLY [ADP-RIBOSE]
POLYMERASE 14


(Homo sapiens)
PF01661
(Macro)
5 LEU A 804
VAL A 806
LEU A 930
ILE A 941
ALA A 940
None
1.08A 4ltwA-4d86A:
undetectable
4ltwA-4d86A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iru LEPB

(Legionella
pneumophila)
no annotation 5 LEU A 521
ILE A 467
GLU A 514
ILE A 517
ALA A 513
None
1.04A 4ltwA-4iruA:
undetectable
4ltwA-4iruA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE


(Haemophilus
influenzae)
PF01380
(SIS)
5 LEU A 214
VAL A 210
ILE A 170
ILE A 168
ALA A 182
None
0.98A 4ltwA-4m0dA:
undetectable
4ltwA-4m0dA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbr SERINE-RICH REPEAT
PROTEIN 2


(Streptococcus
agalactiae)
PF10425
(SdrG_C_C)
5 LEU A 346
VAL A 364
LEU A 242
ILE A 284
ILE A 344
None
1.02A 4ltwA-4mbrA:
undetectable
4ltwA-4mbrA:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
5 LEU A 291
GLN A 312
ILE A 316
GLU A 468
ALA A 472
None
0.79A 4ltwA-4n1yA:
29.6
4ltwA-4n1yA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
5 LEU A 291
LEU A 309
GLN A 312
GLU A 468
ALA A 472
None
0.67A 4ltwA-4n1yA:
29.6
4ltwA-4n1yA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
5 LEU A 291
LYS A 299
GLN A 312
ILE A 316
ALA A 472
None
0.88A 4ltwA-4n1yA:
29.6
4ltwA-4n1yA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
5 LEU A 291
LYS A 299
LEU A 309
GLN A 312
ALA A 472
None
0.83A 4ltwA-4n1yA:
29.6
4ltwA-4n1yA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
7 VAL A 575
LEU A 589
GLN A 592
MET A 593
GLN A 597
GLU A 755
ILE A 756
None
0.75A 4ltwA-4p6wA:
36.6
4ltwA-4p6wA:
62.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE


(Bradyrhizobium
diazoefficiens)
PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg)
6 LEU A 916
VAL A 918
GLN A 801
ILE A 766
ILE A 907
ALA A 906
None
1.30A 4ltwA-4q73A:
undetectable
4ltwA-4q73A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL


(Homo sapiens)
PF13532
(2OG-FeII_Oxy_2)
5 LEU A 110
LEU A 145
ILE A 179
ILE A  70
ALA A  69
OGA  A 301 ( 4.6A)
None
None
None
None
1.09A 4ltwA-4qkfA:
undetectable
4ltwA-4qkfA:
23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
6 VAL A 781
GLN A 798
ILE A 802
GLN A 803
GLU A 962
ILE A 963
None
0.50A 4ltwA-4udbA:
36.1
4ltwA-4udbA:
65.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 VAL A 781
LEU A 795
GLN A 798
ILE A 802
GLN A 803
None
0.73A 4ltwA-4udbA:
36.1
4ltwA-4udbA:
65.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usq PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE


(Cellvibrio sp.
BR)
PF13738
(Pyr_redox_3)
5 LEU A  32
VAL A  28
ILE A  18
ILE A  16
ALA A 130
None
0.99A 4ltwA-4usqA:
undetectable
4ltwA-4usqA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Homo sapiens)
PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD)
5 LEU A1265
MET A1169
GLU A1168
ILE A1167
ALA A1166
None
SAH  A1706 (-3.9A)
SAH  A1706 (-2.8A)
None
None
1.08A 4ltwA-4wxxA:
undetectable
4ltwA-4wxxA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy9 PUTATIVE MCP-TYPE
SIGNAL TRANSDUCTION
PROTEIN


(Campylobacter
jejuni)
PF02743
(dCache_1)
5 LEU A 242
VAL A 240
LEU A  46
ILE A 277
ALA A 276
None
1.08A 4ltwA-4wy9A:
undetectable
4ltwA-4wy9A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcw MOLYBDOPTERIN
ADENYLYLTRANSFERASE


(Helicobacter
pylori)
PF00994
(MoCF_biosynth)
6 LEU A  69
VAL A  71
GLN A 119
ILE A 130
ILE A 150
ALA A 149
None
1.20A 4ltwA-4xcwA:
undetectable
4ltwA-4xcwA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE


(Sulfolobus
acidocaldarius)
PF00180
(Iso_dh)
5 LEU A  55
GLN A   9
ILE A   8
ILE A  63
ALA A  66
None
0.90A 4ltwA-4y1pA:
undetectable
4ltwA-4y1pA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A 249
LEU A 273
ILE A 181
GLN A 182
ILE A 190
ALA A 191
None
None
None
None
None
499  A 401 ( 4.6A)
1.35A 4ltwA-4y85A:
undetectable
4ltwA-4y85A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr8 UROPORPHYRINOGEN
DECARBOXYLASE


(Acinetobacter
baumannii)
PF01208
(URO-D)
5 LEU A 193
VAL A 189
MET A 227
ILE A 230
ALA A 264
None
1.07A 4ltwA-4zr8A:
undetectable
4ltwA-4zr8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aek SENTRIN-SPECIFIC
PROTEASE 2


(Homo sapiens)
PF02902
(Peptidase_C48)
6 LEU A 368
LEU A 422
MET A 372
GLU A 375
ILE A 376
ALA A 379
None
1.04A 4ltwA-5aekA:
undetectable
4ltwA-5aekA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c00 MDBA PROTEIN

(Corynebacterium
diphtheriae)
PF13462
(Thioredoxin_4)
5 VAL A 239
ILE A 114
GLU A 110
ILE A 109
ALA A  73
None
1.09A 4ltwA-5c00A:
undetectable
4ltwA-5c00A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE


(Homo sapiens)
PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C)
5 LEU A 579
GLN A 603
ILE A 604
ILE A 633
ALA A 632
None
1.02A 4ltwA-5c1bA:
undetectable
4ltwA-5c1bA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cml OSMC FAMILY PROTEIN

(Rhodothermus
marinus)
PF12146
(Hydrolase_4)
6 LEU A 244
VAL A 240
LEU A 230
ILE A  50
ILE A 106
ALA A  35
None
1.36A 4ltwA-5cmlA:
undetectable
4ltwA-5cmlA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkc PROBABLE GLOBAL
TRANSCRIPTION
ACTIVATOR SNF2L2


(Homo sapiens)
PF00439
(Bromodomain)
5 LEU A1383
GLN A1386
MET A1387
ILE A1390
MET A1454
None
1.03A 4ltwA-5dkcA:
undetectable
4ltwA-5dkcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqn FRBJ

(Streptomyces
rubellomurinus)
PF02668
(TauD)
6 LEU A  30
VAL A  69
MET A  34
GLU A  37
ILE A  38
ALA A  41
None
1.17A 4ltwA-5eqnA:
undetectable
4ltwA-5eqnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT


(Homo sapiens)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol)
5 LEU C 708
VAL C 712
ILE C 755
ILE C 752
ALA C 541
None
0.98A 4ltwA-5exrC:
undetectable
4ltwA-5exrC:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2v GTP
PYROPHOSPHOKINASE
YJBM


(Bacillus
subtilis)
no annotation 5 LEU V  93
VAL V  89
LEU V 145
ILE V 142
ILE V 140
None
0.93A 4ltwA-5f2vV:
undetectable
4ltwA-5f2vV:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvd NUCLEOCAPSID

(Human
metapneumovirus)
PF03246
(Pneumo_ncap)
5 GLN A  41
ILE A  44
GLN A  68
ILE A 116
ALA A  34
None
1.06A 4ltwA-5fvdA:
undetectable
4ltwA-5fvdA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Mus musculus)
PF00145
(DNA_methylase)
PF01426
(BAH)
5 LEU A1268
MET A1172
GLU A1171
ILE A1170
ALA A1169
None
SAH  A1701 (-3.8A)
SAH  A1701 (-2.7A)
None
None
0.98A 4ltwA-5gutA:
undetectable
4ltwA-5gutA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibz UNCHARACTERIZED
PROTEIN


(uncultured
organism)
PF04199
(Cyclase)
5 VAL A  83
LEU A 126
GLN A 127
ILE A  75
ALA A  74
None
1.08A 4ltwA-5ibzA:
undetectable
4ltwA-5ibzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT


(Homo sapiens)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
5 LEU A 708
VAL A 712
ILE A 755
ILE A 752
ALA A 541
None
1.01A 4ltwA-5iudA:
undetectable
4ltwA-5iudA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldw NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
8, MITOCHONDRIAL


(Bos taurus)
PF12838
(Fer4_7)
5 LEU I 155
LEU I  82
ILE I 131
ILE I 111
ALA I  91
None
SF4  I 202 ( 4.2A)
SF4  I 202 (-4.8A)
None
SF4  I 201 ( 4.5A)
1.08A 4ltwA-5ldwI:
undetectable
4ltwA-5ldwI:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
no annotation 6 VAL A 781
LEU A 795
GLN A 798
ILE A 802
GLN A 803
ILE A 963
None
0.79A 4ltwA-5mwpA:
38.0
4ltwA-5mwpA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION


(Lactobacillus
reuteri)
no annotation 5 LEU A 333
VAL A 331
ILE A 323
ILE A 321
ALA A 293
None
1.03A 4ltwA-5ny0A:
undetectable
4ltwA-5ny0A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM6


(Saccharomyces
cerevisiae)
PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB)
5 LEU 6 185
VAL 6 189
ILE 6 140
GLN 6 139
ILE 6 151
None
1.01A 4ltwA-5udb6:
undetectable
4ltwA-5udb6:
13.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2


(unidentified)
PF00104
(Hormone_recep)
7 VAL A  44
LEU A  58
GLN A  61
MET A  62
GLN A  66
GLU A 224
ILE A 225
None
0.77A 4ltwA-5ufsA:
38.4
4ltwA-5ufsA:
73.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Komagataella
phaffii)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
5 LEU B1010
GLN B 770
GLN B 986
ILE B1012
ALA B1016
None
0.94A 4ltwA-5xogB:
undetectable
4ltwA-5xogB:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE


(Salmonella
enterica)
no annotation 5 LEU A 159
ILE A  74
GLU A 100
ILE A 101
ALA A 103
None
1.07A 4ltwA-6c43A:
undetectable
4ltwA-6c43A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfp VCA0883

(Vibrio cholerae)
no annotation 5 VAL A 211
ILE A 250
GLN A 249
ILE A 186
ALA A 185
None
1.06A 4ltwA-6dfpA:
3.3
4ltwA-6dfpA:
13.82