SIMILAR PATTERNS OF AMINO ACIDS FOR 4LRH_G_FOLG301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1n21	(+)-BORNYL DIPHOSPHATE SYNTHASE (Salvia officinalis)	PF01397 (Terpene_synth) PF03936 (Terpene_synth_C)	5	GLN A 162 ARG A 158 LYS A 114 GLY A 117 TRP A 240	None	1.33A	4lrhG-1n21A: 0.0	4lrhG-1n21A: 15.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4kmz	FOLATE RECEPTOR BETA (Homo sapiens)	PF03024 (Folate_rec)	11	TYR A 76 TYR A 101 GLN A 116 TRP A 118 ARG A 119 ARG A 122 GLY A 153 TRP A 156 TRP A 187 SER A 190 TYR A 191	FOL A 301 (-3.8A) FOL A 301 (-3.8A) FOL A 301 ( 4.8A) FOL A 301 (-4.0A) FOL A 301 (-3.0A) FOL A 301 ( 4.4A) FOL A 301 (-4.0A) FOL A 301 (-3.7A) FOL A 301 (-3.5A) FOL A 301 (-2.6A) FOL A 301 (-4.1A)	0.56A	4lrhG-4kmzA: 35.0	4lrhG-4kmzA: 77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4lrh	FOLATE RECEPTOR ALPHA (Homo sapiens)	PF03024 (Folate_rec)	12	TYR A 60 TYR A 85 GLN A 100 TRP A 102 ARG A 103 ARG A 106 LYS A 136 GLY A 137 TRP A 140 TRP A 171 SER A 174 TYR A 175	FOL A 301 (-3.9A) FOL A 301 (-4.1A) FOL A 301 (-4.3A) FOL A 301 (-4.2A) FOL A 301 (-3.2A) FOL A 301 (-3.8A) FOL A 301 (-4.0A) FOL A 301 (-4.3A) FOL A 301 (-3.6A) FOL A 301 (-3.7A) FOL A 301 (-2.8A) FOL A 301 (-4.1A)	0.36A	4lrhG-4lrhA: 37.1	4lrhG-4lrhA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ox2	PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC [GTP] (Rattus norvegicus)	PF00821 (PEPCK_C) PF17297 (PEPCK_N)	5	TYR A 235 ARG A 405 LYS A 243 GLY A 242 SER A 286	None GTP A 703 ( 2.8A) SPV A 704 (-4.5A) None SPV A 704 ( 2.8A)	1.09A	4lrhG-4ox2A: 0.0	4lrhG-4ox2A: 14.99

[["4LRH_G_FOLG301_0","1n21","Salvia officinalis","(+)-BORNYL DIPHOSPHATE SYNTHASE","PF01397(Terpene_synth);PF03936(Terpene_synth_C)",5,"GLN A 162;ARG A 158;LYS A 114;GLY A 117;TRP A 240","None","1.33A","4lrhG-1n21A:0.0","4lrhG-1n21A:15.97"],["4LRH_G_FOLG301_0","4kmz","Homo sapiens","FOLATE RECEPTOR BETA","PF03024(Folate_rec)",11,"TYR A  76;TYR A 101;GLN A 116;TRP A 118;ARG A 119;ARG A 122;GLY A 153;TRP A 156;TRP A 187;SER A 190;TYR A 191","FOL A 301 (-3.8A);FOL A 301 (-3.8A);FOL A 301 ( 4.8A);FOL A 301 (-4.0A);FOL A 301 (-3.0A);FOL A 301 ( 4.4A);FOL A 301 (-4.0A);FOL A 301 (-3.7A);FOL A 301 (-3.5A);FOL A 301 (-2.6A);FOL A 301 (-4.1A)","0.56A","4lrhG-4kmzA:35.0","4lrhG-4kmzA:77.36"],["4LRH_G_FOLG301_0","4lrh","Homo sapiens","FOLATE RECEPTOR ALPHA","PF03024(Folate_rec)",12,"TYR A  60;TYR A  85;GLN A 100;TRP A 102;ARG A 103;ARG A 106;LYS A 136;GLY A 137;TRP A 140;TRP A 171;SER A 174;TYR A 175","FOL A 301 (-3.9A);FOL A 301 (-4.1A);FOL A 301 (-4.3A);FOL A 301 (-4.2A);FOL A 301 (-3.2A);FOL A 301 (-3.8A);FOL A 301 (-4.0A);FOL A 301 (-4.3A);FOL A 301 (-3.6A);FOL A 301 (-3.7A);FOL A 301 (-2.8A);FOL A 301 (-4.1A)","0.36A","4lrhG-4lrhA:37.1","4lrhG-4lrhA:100.00"],["4LRH_G_FOLG301_0","4ox2","Rattus norvegicus","PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC [GTP]","PF00821(PEPCK_C);PF17297(PEPCK_N)",5,"TYR A 235;ARG A 405;LYS A 243;GLY A 242;SER A 286","None;GTP A 703 ( 2.8A);SPV A 704 (-4.5A);None;SPV A 704 ( 2.8A)","1.09A","4lrhG-4ox2A:0.0","4lrhG-4ox2A:14.99"]]