SIMILAR PATTERNS OF AMINO ACIDS FOR 4LRH_E_FOLE301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4e84	D-BETA-D-HEPTOSE 7-PHOSPHATE KINASE (Burkholderia cenocepacia)	PF00294 (PfkB)	5	ASP A 270 GLN A 122 ARG A 115 ARG A 125 TYR A 159	M7B A 502 (-3.1A) None M7B A 502 (-3.2A) M7B A 502 (-3.1A) M7B A 502 (-4.5A)	1.15A	4lrhE-4e84A: 0.0	4lrhE-4e84A: 18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4kmz	FOLATE RECEPTOR BETA (Homo sapiens)	PF03024 (Folate_rec)	11	TYR A 76 ASP A 97 TYR A 101 GLN A 116 TRP A 118 ARG A 119 ARG A 122 HIS A 151 TRP A 156 TRP A 187 TYR A 191	FOL A 301 (-3.8A) FOL A 301 (-2.8A) FOL A 301 (-3.8A) FOL A 301 ( 4.8A) FOL A 301 (-4.0A) FOL A 301 (-3.0A) FOL A 301 ( 4.4A) FOL A 301 (-3.9A) FOL A 301 (-3.7A) FOL A 301 (-3.5A) FOL A 301 (-4.1A)	0.49A	4lrhE-4kmzA: 35.0	4lrhE-4kmzA: 77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4lrh	FOLATE RECEPTOR ALPHA (Homo sapiens)	PF03024 (Folate_rec)	12	TYR A 60 ASP A 81 TYR A 85 GLN A 100 TRP A 102 ARG A 103 ARG A 106 HIS A 135 LYS A 136 TRP A 140 TRP A 171 TYR A 175	FOL A 301 (-3.9A) FOL A 301 (-2.7A) FOL A 301 (-4.1A) FOL A 301 (-4.3A) FOL A 301 (-4.2A) FOL A 301 (-3.2A) FOL A 301 (-3.8A) FOL A 301 (-4.1A) FOL A 301 (-4.0A) FOL A 301 (-3.6A) FOL A 301 (-3.7A) FOL A 301 (-4.1A)	0.34A	4lrhE-4lrhA: 37.1	4lrhE-4lrhA: 100.00

[["4LRH_E_FOLE301_0","4e84","Burkholderia cenocepacia","D-BETA-D-HEPTOSE 7-PHOSPHATE KINASE","PF00294(PfkB)",5,"ASP A 270;GLN A 122;ARG A 115;ARG A 125;TYR A 159","M7B A 502 (-3.1A);None;M7B A 502 (-3.2A);M7B A 502 (-3.1A);M7B A 502 (-4.5A)","1.15A","4lrhE-4e84A:0.0","4lrhE-4e84A:18.48"],["4LRH_E_FOLE301_0","4kmz","Homo sapiens","FOLATE RECEPTOR BETA","PF03024(Folate_rec)",11,"TYR A  76;ASP A  97;TYR A 101;GLN A 116;TRP A 118;ARG A 119;ARG A 122;HIS A 151;TRP A 156;TRP A 187;TYR A 191","FOL A 301 (-3.8A);FOL A 301 (-2.8A);FOL A 301 (-3.8A);FOL A 301 ( 4.8A);FOL A 301 (-4.0A);FOL A 301 (-3.0A);FOL A 301 ( 4.4A);FOL A 301 (-3.9A);FOL A 301 (-3.7A);FOL A 301 (-3.5A);FOL A 301 (-4.1A)","0.49A","4lrhE-4kmzA:35.0","4lrhE-4kmzA:77.36"],["4LRH_E_FOLE301_0","4lrh","Homo sapiens","FOLATE RECEPTOR ALPHA","PF03024(Folate_rec)",12,"TYR A  60;ASP A  81;TYR A  85;GLN A 100;TRP A 102;ARG A 103;ARG A 106;HIS A 135;LYS A 136;TRP A 140;TRP A 171;TYR A 175","FOL A 301 (-3.9A);FOL A 301 (-2.7A);FOL A 301 (-4.1A);FOL A 301 (-4.3A);FOL A 301 (-4.2A);FOL A 301 (-3.2A);FOL A 301 (-3.8A);FOL A 301 (-4.1A);FOL A 301 (-4.0A);FOL A 301 (-3.6A);FOL A 301 (-3.7A);FOL A 301 (-4.1A)","0.34A","4lrhE-4lrhA:37.1","4lrhE-4lrhA:100.00"]]