SIMILAR PATTERNS OF AMINO ACIDS FOR 4LRH_D_FOLD301_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bu8 | PROTEIN (PANCREATICLIPASE RELATEDPROTEIN 2) (Rattusnorvegicus) |
PF00151(Lipase)PF01477(PLAT) | 3 | HIS A 151TRP A 106SER A 266 | None | 1.13A | 4lrhD-1bu8A:0.0 | 4lrhD-1bu8A:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d4m | PROTEIN(COXSACKIEVIRUS A9) (Enterovirus B) |
PF00073(Rhv) | 3 | HIS 1 223TRP 1 162SER 1 125 | None | 1.11A | 4lrhD-1d4m1:undetectable | 4lrhD-1d4m1:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d7w | MYELOPEROXIDASE (Homo sapiens) |
PF03098(An_peroxidase) | 3 | HIS C 428TRP C 436SER C 149 | NoneNoneCSO C 150 ( 4.4A) | 0.91A | 4lrhD-1d7wC:0.0 | 4lrhD-1d7wC:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ece | ENDOCELLULASE E1 (Acidothermuscellulolyticus) |
PF00150(Cellulase) | 3 | HIS A 39TRP A 319SER A 78 | NoneBGC A 403 ( 4.2A)None | 1.10A | 4lrhD-1eceA:0.0 | 4lrhD-1eceA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eth | TRIACYLGLYCEROLACYL-HYDROLASE (Sus scrofa) |
PF00151(Lipase)PF01477(PLAT) | 3 | HIS A 152TRP A 107SER A 267 | C8E A 456 (-3.3A)NoneNone | 1.21A | 4lrhD-1ethA:0.0 | 4lrhD-1ethA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fp3 | N-ACYL-D-GLUCOSAMINE2-EPIMERASE (Sus scrofa) |
PF07221(GlcNAc_2-epim) | 3 | HIS A 382TRP A 56SER A 317 | None | 0.99A | 4lrhD-1fp3A:undetectable | 4lrhD-1fp3A:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpl | RP2 LIPASE (Cavia porcellus) |
PF00151(Lipase)PF01477(PLAT) | 3 | HIS A 151TRP A 106SER A 266 | None | 1.17A | 4lrhD-1gplA:0.0 | 4lrhD-1gplA:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gw1 | MANNANENDO-1,4-BETA-MANNOSIDASE (Cellvibriojaponicus) |
PF02156(Glyco_hydro_26) | 3 | HIS A 143TRP A 156SER A 141 | MAF A1427 ( 3.9A)NoneNone | 1.13A | 4lrhD-1gw1A:undetectable | 4lrhD-1gw1A:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hlg | LIPASE, GASTRIC (Homo sapiens) |
PF00561(Abhydrolase_1) | 3 | HIS A 65TRP A 358SER A 99 | None | 0.90A | 4lrhD-1hlgA:0.0 | 4lrhD-1hlgA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hpl | LIPASE (Equus caballus) |
PF00151(Lipase)PF01477(PLAT) | 3 | HIS A 151TRP A 106SER A 266 | None | 1.15A | 4lrhD-1hplA:0.0 | 4lrhD-1hplA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jdi | L-RIBULOSE 5PHOSPHATE4-EPIMERASE (Escherichiacoli) |
PF00596(Aldolase_II) | 3 | HIS A 80TRP A 176SER A 74 | None | 0.84A | 4lrhD-1jdiA:undetectable | 4lrhD-1jdiA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqg | CARBOXYPEPTIDASE A (Helicoverpaarmigera) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 3 | HIS A 13TRP A 73SER A 2 | None | 1.18A | 4lrhD-1jqgA:undetectable | 4lrhD-1jqgA:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k8q | TRIACYLGLYCEROLLIPASE, GASTRIC (Canis lupus) |
PF00561(Abhydrolase_1) | 3 | HIS A 65TRP A 358SER A 99 | None | 1.06A | 4lrhD-1k8qA:undetectable | 4lrhD-1k8qA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcx | DIHYDROPYRIMIDINASERELATED PROTEIN-1 (Mus musculus) |
PF01979(Amidohydro_1) | 3 | HIS A 223TRP A 295SER A 304 | None | 1.14A | 4lrhD-1kcxA:undetectable | 4lrhD-1kcxA:17.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lla | HEMOCYANIN (SUBUNITTYPE II) (Limuluspolyphemus) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 3 | HIS A 328TRP A 326SER A 354 | CU A 630 (-3.2A)NoneNone | 1.20A | 4lrhD-1llaA:undetectable | 4lrhD-1llaA:16.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lpb | LIPASE (Homo sapiens) |
PF00151(Lipase)PF01477(PLAT) | 3 | HIS B 151TRP B 106SER B 266 | MUP B 901 (-4.5A)NoneNone | 1.14A | 4lrhD-1lpbB:undetectable | 4lrhD-1lpbB:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lzx | NITRIC-OXIDESYNTHASE (Rattusnorvegicus) |
PF02898(NO_synthase) | 3 | HIS A 407TRP A 409SER A 368 | NoneHEM A 750 (-3.4A)None | 1.22A | 4lrhD-1lzxA:undetectable | 4lrhD-1lzxA:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m2p | CASEIN KINASE II,ALPHA CHAIN (Zea mays) |
PF00069(Pkinase) | 3 | HIS A 309TRP A 216SER A 7 | None | 1.19A | 4lrhD-1m2pA:undetectable | 4lrhD-1m2pA:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mqt | POLYPROTEIN (Enterovirus B) |
PF00073(Rhv) | 3 | HIS A 222TRP A 161SER A 124 | None | 1.23A | 4lrhD-1mqtA:undetectable | 4lrhD-1mqtA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nmb | N9 NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 3 | HIS N 312TRP N 265SER N 314 | None | 1.22A | 4lrhD-1nmbN:undetectable | 4lrhD-1nmbN:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1otw | COENZYME PQQSYNTHESIS PROTEIN C (Klebsiellapneumoniae) |
PF03070(TENA_THI-4) | 3 | HIS A 30TRP A 219SER A 156 | None | 1.18A | 4lrhD-1otwA:undetectable | 4lrhD-1otwA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r44 | D-ALANYL-D-ALANINEDIPEPTIDASE (Enterococcusfaecium) |
PF01427(Peptidase_M15) | 3 | HIS A 184TRP A 182SER A 115 | ZN A 203 (-3.5A)NoneNone | 1.05A | 4lrhD-1r44A:undetectable | 4lrhD-1r44A:16.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1umi | F-BOX ONLY PROTEIN 2 (Mus musculus) |
PF04300(FBA) | 3 | HIS A 272TRP A 179SER A 291 | None | 1.08A | 4lrhD-1umiA:undetectable | 4lrhD-1umiA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vj0 | ALCOHOLDEHYDROGENASE,ZINC-CONTAINING (Thermotogamaritima) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | HIS A 65TRP A 94SER A 45 | ZN A 401 (-3.4A)None ZN A 401 ( 4.2A) | 1.20A | 4lrhD-1vj0A:undetectable | 4lrhD-1vj0A:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w52 | PANCREATIC LIPASERELATED PROTEIN 2 (Equus caballus) |
PF00151(Lipase)PF01477(PLAT) | 3 | HIS X 153TRP X 108SER X 268 | None | 1.21A | 4lrhD-1w52X:undetectable | 4lrhD-1w52X:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw6 | BLL6730 PROTEIN (Bradyrhizobiumjaponicum) |
PF13378(MR_MLE_C) | 3 | HIS A 322TRP A 237SER A 54 | TAR A1001 (-3.7A)NoneNone | 1.16A | 4lrhD-2dw6A:undetectable | 4lrhD-2dw6A:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e32 | F-BOX ONLY PROTEIN 2 (Mus musculus) |
PF00646(F-box)PF04300(FBA) | 3 | HIS A 272TRP A 179SER A 291 | None | 1.10A | 4lrhD-2e32A:undetectable | 4lrhD-2e32A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ppl | PANCREATICLIPASE-RELATEDPROTEIN 1 (Homo sapiens) |
PF00151(Lipase)PF01477(PLAT) | 3 | HIS A 170TRP A 125SER A 284 | None | 1.07A | 4lrhD-2pplA:undetectable | 4lrhD-2pplA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pvs | PANCREATICLIPASE-RELATEDPROTEIN 2 (Homo sapiens) |
PF00151(Lipase)PF01477(PLAT) | 3 | HIS A 151TRP A 106SER A 266 | None | 1.14A | 4lrhD-2pvsA:undetectable | 4lrhD-2pvsA:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r2d | ZN-DEPENDENTHYDROLASES (Agrobacteriumfabrum) |
PF00753(Lactamase_B) | 3 | HIS A 116TRP A 72SER A 212 | ZN A 277 ( 3.2A)NoneNone | 1.15A | 4lrhD-2r2dA:undetectable | 4lrhD-2r2dA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vrk | ALPHA-L-ARABINOFURANOSIDASE (Thermobacillusxylanilyticus) |
PF06964(Alpha-L-AF_C) | 3 | HIS A 334TRP A 299SER A 407 | None | 1.07A | 4lrhD-2vrkA:undetectable | 4lrhD-2vrkA:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ww2 | ALPHA-1,2-MANNOSIDASE (Bacteroidesthetaiotaomicron) |
PF07971(Glyco_hydro_92) | 3 | HIS A 396TRP A 391SER A 385 | NoneGOL A 805 (-4.4A)None | 1.18A | 4lrhD-2ww2A:undetectable | 4lrhD-2ww2A:13.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wzs | PUTATIVEALPHA-1,2-MANNOSIDASE (Bacteroidesthetaiotaomicron) |
PF07971(Glyco_hydro_92) | 3 | HIS A 390TRP A 385SER A 379 | NoneMVL A 801 (-3.9A)None | 1.13A | 4lrhD-2wzsA:undetectable | 4lrhD-2wzsA:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3avs | LYSINE-SPECIFICDEMETHYLASE 6A (Homo sapiens) |
PF02373(JmjC) | 3 | HIS A1226TRP A1194SER A1154 | NI A1503 ( 3.4A)NoneOGA A1501 (-2.7A) | 1.17A | 4lrhD-3avsA:undetectable | 4lrhD-3avsA:17.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayn | RHODOPSIN (Todarodespacificus) |
PF00001(7tm_1) | 3 | HIS A 20TRP A 12SER A 192 | None | 1.09A | 4lrhD-3aynA:undetectable | 4lrhD-3aynA:15.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bu7 | GENTISATE1,2-DIOXYGENASE (Ruegeriapomeroyi) |
PF07883(Cupin_2) | 3 | HIS A 290TRP A 327SER A 252 | FE2 A 500 (-3.5A)NoneNone | 1.10A | 4lrhD-3bu7A:undetectable | 4lrhD-3bu7A:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dc8 | DIHYDROPYRIMIDINASE (Sinorhizobiummeliloti) |
PF01979(Amidohydro_1) | 3 | HIS A 205TRP A 277SER A 286 | None | 1.16A | 4lrhD-3dc8A:undetectable | 4lrhD-3dc8A:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dmk | DOWN SYNDROME CELLADHESION MOLECULE(DSCAM) ISOFORM1.30.30, N-TERMINALEIGHT IG DOMAINS (Drosophilamelanogaster) |
PF07679(I-set)PF13927(Ig_3) | 3 | HIS A 167TRP A 140SER A 270 | GOL A 786 (-3.8A)NoneGOL A 786 (-3.5A) | 1.00A | 4lrhD-3dmkA:undetectable | 4lrhD-3dmkA:14.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e3b | CASEIN KINASE IISUBUNIT ALPHA' (Homo sapiens) |
PF00069(Pkinase) | 3 | HIS X 310TRP X 217SER X 8 | None | 1.21A | 4lrhD-3e3bX:undetectable | 4lrhD-3e3bX:16.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g77 | CYTOSINE DEAMINASE (Escherichiacoli) |
PF07969(Amidohydro_3) | 3 | HIS A 214TRP A 88SER A 245 | FE A 502 (-3.6A)NoneNone | 1.23A | 4lrhD-3g77A:undetectable | 4lrhD-3g77A:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hvd | PROTECTIVE ANTIGEN (Bacillusanthracis) |
PF03495(Binary_toxB)PF17475(Binary_toxB_2)PF17476(Binary_toxB_3) | 3 | HIS A 336TRP A 346SER A 640 | None | 1.23A | 4lrhD-3hvdA:undetectable | 4lrhD-3hvdA:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j2j | PROTEIN VP1 (Enterovirus B) |
PF00073(Rhv) | 3 | HIS A 161TRP A 100SER A 63 | None | 1.11A | 4lrhD-3j2jA:undetectable | 4lrhD-3j2jA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j8g | GTPASE DER (Escherichiacoli) |
PF01926(MMR_HSR1)PF14714(KH_dom-like) | 3 | HIS X 351TRP X 323SER X 367 | None | 1.17A | 4lrhD-3j8gX:undetectable | 4lrhD-3j8gX:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jd5 | 28S RIBOSOMALPROTEIN S9,MITOCHONDRIAL (Bos taurus) |
PF00380(Ribosomal_S9) | 3 | HIS I 148TRP I 140SER I 160 | None | 1.03A | 4lrhD-3jd5I:undetectable | 4lrhD-3jd5I:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kw7 | LACCASE B (Trametes sp.AH28-2) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 3 | HIS A 403TRP A 452SER A 241 | CU A 602 (-3.0A)None CU A 604 ( 4.7A) | 1.13A | 4lrhD-3kw7A:undetectable | 4lrhD-3kw7A:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm3 | UNCHARACTERIZEDPROTEIN (Parabacteroidesdistasonis) |
PF12979(DUF3863)PF12980(DUF3864) | 3 | HIS A 297TRP A 342SER A 217 | None | 0.99A | 4lrhD-3lm3A:undetectable | 4lrhD-3lm3A:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3msu | CITRATE SYNTHASE (Francisellatularensis) |
PF00285(Citrate_synt) | 3 | HIS A 228TRP A 394SER A 368 | None | 1.15A | 4lrhD-3msuA:undetectable | 4lrhD-3msuA:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ozy | PUTATIVE MANDELATERACEMASE (Bordetellabronchiseptica) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | HIS A 304TRP A 225SER A 53 | None | 1.08A | 4lrhD-3ozyA:undetectable | 4lrhD-3ozyA:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3stt | METHYLKETONESYNTHASE I (Solanumhabrochaites) |
PF12697(Abhydrolase_6) | 3 | HIS A 86TRP A 24SER A 111 | None | 0.94A | 4lrhD-3sttA:undetectable | 4lrhD-3sttA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tex | PROTECTIVE ANTIGEN (Bacillusanthracis) |
PF03495(Binary_toxB)PF07691(PA14)PF17475(Binary_toxB_2)PF17476(Binary_toxB_3) | 3 | HIS A 336TRP A 346SER A 640 | None | 1.00A | 4lrhD-3texA:undetectable | 4lrhD-3texA:16.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v9f | TWO-COMPONENT SYSTEMSENSOR HISTIDINEKINASE/RESPONSEREGULATOR, HYBRID(ONE-COMPONENTSYSTEM) (Bacteroidesthetaiotaomicron) |
PF07494(Reg_prop)PF07495(Y_Y_Y) | 3 | HIS A 776TRP A 780SER A 637 | None | 0.83A | 4lrhD-3v9fA:undetectable | 4lrhD-3v9fA:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vc1 | GERANYL DIPHOSPHATE2-C-METHYLTRANSFERASE (Streptomycescoelicolor) |
PF08241(Methyltransf_11) | 3 | HIS A 50TRP A 257SER A 111 | SAH A 302 ( 3.8A)NoneSAH A 302 ( 4.1A) | 1.15A | 4lrhD-3vc1A:undetectable | 4lrhD-3vc1A:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vtr | N-ACETYLGLUCOSAMINIDASE (Ostriniafurnacalis) |
PF00728(Glyco_hydro_20)PF14845(Glycohydro_20b2) | 3 | HIS A 303TRP A 448SER A 250 | TCG A 601 (-4.1A)TCG A 601 (-4.0A)None | 1.05A | 4lrhD-3vtrA:undetectable | 4lrhD-3vtrA:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vyl | L-RIBULOSE3-EPIMERASE (Mesorhizobiumloti) |
PF01261(AP_endonuc_2) | 3 | HIS A 7TRP A 263SER A 64 | None | 1.22A | 4lrhD-3vylA:undetectable | 4lrhD-3vylA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wwx | S12 FAMILY PEPTIDASE (Streptomycessp. 82F2) |
PF00144(Beta-lactamase) | 3 | HIS A 339TRP A 167SER A 246 | DIA A 401 (-2.7A)NoneDIA A 401 (-2.8A) | 1.18A | 4lrhD-3wwxA:undetectable | 4lrhD-3wwxA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a25 | FERRITIN DPS FAMILYPROTEIN (Kineococcusradiotolerans) |
PF00210(Ferritin) | 3 | HIS A 41TRP A 49SER A 74 | None | 1.08A | 4lrhD-4a25A:undetectable | 4lrhD-4a25A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c7g | BETA-N-ACETYLHEXOSAMINIDASE (Streptomycescoelicolor) |
PF00728(Glyco_hydro_20)PF02838(Glyco_hydro_20b) | 3 | HIS A 176TRP A 349SER A 149 | NoneNGO A1495 ( 3.4A)None | 1.17A | 4lrhD-4c7gA:undetectable | 4lrhD-4c7gA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cns | DIHYDROPYRIMIDINASE-LIKE 3 (Homo sapiens) |
PF01979(Amidohydro_1) | 3 | HIS A 223TRP A 295SER A 304 | None | 1.14A | 4lrhD-4cnsA:undetectable | 4lrhD-4cnsA:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cv5 | PROTEIN CAF40 (Saccharomycescerevisiae) |
PF04078(Rcd1) | 3 | HIS B 194TRP B 143SER B 237 | None | 1.14A | 4lrhD-4cv5B:undetectable | 4lrhD-4cv5B:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eyu | LYSINE-SPECIFICDEMETHYLASE 6B (Mus musculus) |
PF02373(JmjC) | 3 | HIS A1470TRP A1438SER A1398 | NI A1701 ( 3.1A)NoneOGA A1700 (-2.8A) | 1.16A | 4lrhD-4eyuA:undetectable | 4lrhD-4eyuA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f85 | GERANYL DIPHOSPHATE2-C-METHYLTRANSFERASE (Streptomyceslasaliensis) |
PF02353(CMAS) | 3 | HIS A 58TRP A 265SER A 119 | None | 1.17A | 4lrhD-4f85A:undetectable | 4lrhD-4f85A:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fbd | PUTATIVEUNCHARACTERIZEDPROTEIN (Toxoplasmagondii) |
PF11539(DUF3228) | 3 | HIS A 76TRP A 165SER A 178 | None | 1.07A | 4lrhD-4fbdA:undetectable | 4lrhD-4fbdA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g6b | CITRATE SYNTHASE (Escherichiacoli) |
PF00285(Citrate_synt) | 3 | HIS A 226TRP A 391SER A 365 | None | 1.07A | 4lrhD-4g6bA:undetectable | 4lrhD-4g6bA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hhv | COLLAGEN TYPE IVALPHA-3-BINDINGPROTEIN (Homo sapiens) |
PF00169(PH) | 3 | HIS A 115TRP A 108SER A 119 | NoneGOL A 202 ( 4.0A)None | 1.23A | 4lrhD-4hhvA:undetectable | 4lrhD-4hhvA:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4if2 | PHOSPHOTRIESTERASEHOMOLOGY PROTEIN (Mycobacteriumtuberculosis) |
PF02126(PTE) | 3 | HIS A 22TRP A 284SER A 176 | ZN A 401 (-3.4A)NoneNone | 1.16A | 4lrhD-4if2A:undetectable | 4lrhD-4if2A:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jr7 | CASEIN KINASE IISUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00069(Pkinase) | 3 | HIS A 348TRP A 255SER A 7 | None | 1.21A | 4lrhD-4jr7A:undetectable | 4lrhD-4jr7A:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k2a | HALOALKANEDEHALOGENASE (Bradyrhizobiumelkanii) |
PF00561(Abhydrolase_1) | 3 | HIS A 139TRP A 135SER A 175 | None | 1.21A | 4lrhD-4k2aA:undetectable | 4lrhD-4k2aA:16.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kem | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Azospirillumlipoferum) |
PF13378(MR_MLE_C) | 3 | HIS A 321TRP A 236SER A 52 | AKR A 405 (-4.6A)NoneNone | 1.18A | 4lrhD-4kemA:undetectable | 4lrhD-4kemA:19.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4kmz | FOLATE RECEPTOR BETA (Homo sapiens) |
PF03024(Folate_rec) | 3 | HIS A 151TRP A 156SER A 190 | FOL A 301 (-3.9A)FOL A 301 (-3.7A)FOL A 301 (-2.6A) | 0.24A | 4lrhD-4kmzA:34.8 | 4lrhD-4kmzA:77.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lrh | FOLATE RECEPTORALPHA (Homo sapiens) |
PF03024(Folate_rec) | 3 | HIS A 135TRP A 140SER A 174 | FOL A 301 (-4.1A)FOL A 301 (-3.6A)FOL A 301 (-2.8A) | 0.17A | 4lrhD-4lrhA:37.2 | 4lrhD-4lrhA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4md8 | CASEIN KINASE IISUBUNIT ALPHA (Homo sapiens) |
PF00069(Pkinase) | 3 | HIS E 309TRP E 216SER E 7 | None | 1.21A | 4lrhD-4md8E:undetectable | 4lrhD-4md8E:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p1c | TOLUENE-4-MONOOXYGENASE SYSTEM PROTEIN ATOLUENE-4-MONOOXYGENASE SYSTEM PROTEIN E (Pseudomonasmendocina;Pseudomonasmendocina) |
PF02332(Phenol_Hydrox)PF02332(Phenol_Hydrox) | 3 | HIS B 165TRP A 9SER B 253 | None | 1.19A | 4lrhD-4p1cB:undetectable | 4lrhD-4p1cB:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p69 | ISOCITRATEDEHYDROGENASEKINASE/PHOSPHATASE (Escherichiacoli) |
PF06315(AceK) | 3 | HIS A 468TRP A 425SER A 247 | None | 1.09A | 4lrhD-4p69A:undetectable | 4lrhD-4p69A:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p7w | L-PROLINECIS-4-HYDROXYLASE (Mesorhizobiumjaponicum) |
PF05118(Asp_Arg_Hydrox)PF05373(Pro_3_hydrox_C) | 3 | HIS A 231TRP A 200SER A 155 | None | 1.01A | 4lrhD-4p7wA:undetectable | 4lrhD-4p7wA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r27 | GLYCOSIDE HYDROLASE (Microbacteriumsp. Gsoil167) |
PF00232(Glyco_hydro_1) | 3 | HIS A 126TRP A 249SER A 130 | None | 1.10A | 4lrhD-4r27A:undetectable | 4lrhD-4r27A:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqt | D-HYDANTOINASE (Brucella suis) |
PF01979(Amidohydro_1) | 3 | HIS A 209TRP A 281SER A 290 | None | 1.22A | 4lrhD-4tqtA:undetectable | 4lrhD-4tqtA:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tuf | MAJOR EXTRACELLULARENDOGLUCANASE (Xanthomonascampestris) |
PF00150(Cellulase) | 3 | HIS A 60TRP A 337SER A 99 | None | 1.21A | 4lrhD-4tufA:undetectable | 4lrhD-4tufA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u7t | DNA(CYTOSINE-5)-METHYLTRANSFERASE 3A (Homo sapiens) |
PF00145(DNA_methylase) | 3 | HIS A 506TRP A 601SER A 496 | None | 1.15A | 4lrhD-4u7tA:undetectable | 4lrhD-4u7tA:18.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uw7 | L-SHAPED TAIL FIBERPROTEIN (Escherichiavirus T5) |
no annotation | 3 | HIS A1043TRP A1058SER A1038 | None | 1.12A | 4lrhD-4uw7A:undetectable | 4lrhD-4uw7A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ww3 | RHODOPSIN (Todarodespacificus) |
PF00001(7tm_1) | 3 | HIS A 20TRP A 12SER A 192 | None | 1.15A | 4lrhD-4ww3A:undetectable | 4lrhD-4ww3A:15.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xmm | NUCLEOPORIN SEH1 (Saccharomycescerevisiae) |
PF00400(WD40) | 3 | HIS C 13TRP C 308SER C 57 | None | 1.14A | 4lrhD-4xmmC:undetectable | 4lrhD-4xmmC:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxw | C-DOMAIN TYPE IIPEPTIDE SYNTHETASE (Streptomycesglobisporus) |
PF00668(Condensation) | 3 | HIS A 154TRP A 241SER A 306 | 4T7 A 501 (-4.1A)SUC A 502 (-4.5A)None | 0.99A | 4lrhD-4zxwA:undetectable | 4lrhD-4zxwA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dbj | FADH2-DEPENDENTHALOGENASE PLTA (Pseudomonasprotegens) |
no annotation | 3 | HIS E 229TRP E 237SER E 215 | None | 0.90A | 4lrhD-5dbjE:undetectable | 4lrhD-5dbjE:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dkx | ALPHAGLUCOSIDASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF17137(DUF5110) | 3 | HIS A 484TRP A 554SER A 521 | NoneTRS A1001 (-4.9A)None | 1.19A | 4lrhD-5dkxA:undetectable | 4lrhD-5dkxA:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fv4 | CARBOXYLIC ESTERHYDROLASE (Sus scrofa) |
PF00135(COesterase) | 3 | HIS A 449TRP A 339SER A 204 | None | 1.12A | 4lrhD-5fv4A:undetectable | 4lrhD-5fv4A:16.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5htp | PROBABLE SUGARKINASE (Synechococcuselongatus) |
PF02782(FGGY_C) | 3 | HIS A 265TRP A 271SER A 72 | None | 1.09A | 4lrhD-5htpA:undetectable | 4lrhD-5htpA:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5htv | PUTATIVE XYLULOSEKINASE (Arabidopsisthaliana) |
PF00370(FGGY_N)PF02782(FGGY_C) | 3 | HIS A 280TRP A 286SER A 86 | None | 1.22A | 4lrhD-5htvA:undetectable | 4lrhD-5htvA:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kkb | MANNOSYL-OLIGOSACCHARIDE1,2-ALPHA-MANNOSIDASE IA (Mus musculus) |
PF01532(Glyco_hydro_47) | 3 | HIS A 407TRP A 464SER A 343 | None | 1.21A | 4lrhD-5kkbA:undetectable | 4lrhD-5kkbA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mfa | MYELOPEROXIDASE (Homo sapiens) |
PF03098(An_peroxidase) | 3 | HIS A 594TRP A 602SER A 315 | NoneNoneCSO A 316 ( 4.3A) | 0.99A | 4lrhD-5mfaA:undetectable | 4lrhD-5mfaA:13.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msw | THIOESTER REDUCTASEDOMAIN-CONTAININGPROTEIN (Segniliparusrugosus) |
PF00501(AMP-binding)PF00550(PP-binding) | 3 | HIS A 315TRP A 290SER A 625 | AMP A1201 (-4.6A)NoneNone | 0.88A | 4lrhD-5mswA:undetectable | 4lrhD-5mswA:11.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nd1 | CAPSID PROTEIN (Rosellinianecatrixquadrivirus 1) |
no annotation | 3 | HIS B 686TRP B 273SER B 684 | None | 0.93A | 4lrhD-5nd1B:undetectable | 4lrhD-5nd1B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nks | DIHYDROPYRIMIDINASE-RELATED PROTEIN 4 (Homo sapiens) |
no annotation | 3 | HIS A 223TRP A 295SER A 304 | HIS A 223 ( 1.0A)TRP A 295 ( 0.5A)SER A 304 ( 0.0A) | 1.18A | 4lrhD-5nksA:undetectable | 4lrhD-5nksA:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5svc | ACETONE CARBOXYLASEALPHA SUBUNIT (Xanthobacterautotrophicus) |
PF02538(Hydantoinase_B) | 3 | HIS A 317TRP A 546SER A 721 | None | 1.18A | 4lrhD-5svcA:undetectable | 4lrhD-5svcA:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w16 | GLUTAMATE RACEMASE (Thermusthermophilus) |
no annotation | 3 | HIS A 178TRP A 149SER A 13 | DGL A 301 ( 3.9A)NoneDGL A 301 (-2.6A) | 1.17A | 4lrhD-5w16A:undetectable | 4lrhD-5w16A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x55 | PROBABLE URACIL-DNAGLYCOSYLASE (Acanthamoebapolyphagamimivirus) |
PF03167(UDG) | 3 | HIS A 350TRP A 368SER A 316 | None | 1.03A | 4lrhD-5x55A:undetectable | 4lrhD-5x55A:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ykd | D-HYDANTOINASE/DIHYDROPYRIMIDINASE (Pseudomonasaeruginosa) |
no annotation | 3 | HIS A 208TRP A 280SER A 289 | None | 1.16A | 4lrhD-5ykdA:undetectable | 4lrhD-5ykdA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6any | BM4233, ISOFORM B (Brugia malayi) |
no annotation | 3 | HIS A 181TRP A 67SER A 87 | None | 1.14A | 4lrhD-6anyA:undetectable | 4lrhD-6anyA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6azp | MYELOPEROXIDASE (Homo sapiens) |
no annotation | 3 | HIS A 594TRP A 602SER A 315 | NoneNoneCSO A 316 ( 4.4A) | 1.06A | 4lrhD-6azpA:undetectable | 4lrhD-6azpA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bhu | MULTIDRUGRESISTANCE-ASSOCIATED PROTEIN 1 (Bos taurus) |
no annotation | 3 | HIS A 622TRP A 261SER A 417 | None | 0.71A | 4lrhD-6bhuA:undetectable | 4lrhD-6bhuA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ch0 | - (-) |
no annotation | 3 | HIS C 123TRP C 79SER C 219 | CO C 301 (-3.3A)NoneNone | 1.20A | 4lrhD-6ch0C:undetectable | 4lrhD-6ch0C:undetectable |