SIMILAR PATTERNS OF AMINO ACIDS FOR 4LRH_D_FOLD301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kmz FOLATE RECEPTOR BETA

(Homo sapiens) 		PF03024
(Folate_rec) 		11 TYR A  76
ASP A  97
TYR A 101
GLN A 116
SER A 117
TRP A 118
ARG A 119
ARG A 122
TRP A 154
TRP A 187
TYR A 191
 FOL  A 301 (-3.8A)
FOL  A 301 (-2.8A)
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
None
FOL  A 301 (-3.5A)
FOL  A 301 (-4.1A)
 0.49A 4lrhD-4kmzA:
34.8		 4lrhD-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lrh FOLATE RECEPTOR
ALPHA

(Homo sapiens) 		PF03024
(Folate_rec) 		6 ASP A  81
GLN A 100
ARG A 106
LYS A 136
TRP A 138
TRP A 171
 FOL  A 301 (-2.7A)
FOL  A 301 (-4.3A)
FOL  A 301 (-3.8A)
FOL  A 301 (-4.0A)
None
FOL  A 301 (-3.7A)
 1.44A 4lrhD-4lrhA:
37.2		 4lrhD-4lrhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lrh FOLATE RECEPTOR
ALPHA

(Homo sapiens) 		PF03024
(Folate_rec) 		12 TYR A  60
ASP A  81
TYR A  85
GLN A 100
SER A 101
TRP A 102
ARG A 103
ARG A 106
LYS A 136
TRP A 138
TRP A 171
TYR A 175
 FOL  A 301 (-3.9A)
FOL  A 301 (-2.7A)
FOL  A 301 (-4.1A)
FOL  A 301 (-4.3A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.2A)
FOL  A 301 (-3.2A)
FOL  A 301 (-3.8A)
FOL  A 301 (-4.0A)
None
FOL  A 301 (-3.7A)
FOL  A 301 (-4.1A)
 0.45A 4lrhD-4lrhA:
37.2		 4lrhD-4lrhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)

(Rattus
norvegicus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 HIS A 151
TRP A 106
SER A 266
 None
 1.13A 4lrhD-1bu8A:
0.0		 4lrhD-1bu8A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4m PROTEIN
(COXSACKIEVIRUS A9)

(Enterovirus B) 		PF00073
(Rhv) 		3 HIS 1 223
TRP 1 162
SER 1 125
 None
 1.11A 4lrhD-1d4m1:
undetectable		 4lrhD-1d4m1:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		3 HIS C 428
TRP C 436
SER C 149
 None
None
CSO  C 150 ( 4.4A)
 0.91A 4lrhD-1d7wC:
0.0		 4lrhD-1d7wC:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		3 HIS A  39
TRP A 319
SER A  78
 None
BGC  A 403 ( 4.2A)
None
 1.10A 4lrhD-1eceA:
0.0		 4lrhD-1eceA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 HIS A 152
TRP A 107
SER A 267
 C8E  A 456 (-3.3A)
None
None
 1.21A 4lrhD-1ethA:
0.0		 4lrhD-1ethA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp3 N-ACYL-D-GLUCOSAMINE
2-EPIMERASE

(Sus scrofa) 		PF07221
(GlcNAc_2-epim) 		3 HIS A 382
TRP A  56
SER A 317
 None
 0.99A 4lrhD-1fp3A:
undetectable		 4lrhD-1fp3A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpl RP2 LIPASE

(Cavia porcellus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 HIS A 151
TRP A 106
SER A 266
 None
 1.17A 4lrhD-1gplA:
0.0		 4lrhD-1gplA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gw1 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		3 HIS A 143
TRP A 156
SER A 141
 MAF  A1427 ( 3.9A)
None
None
 1.13A 4lrhD-1gw1A:
undetectable		 4lrhD-1gw1A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		3 HIS A  65
TRP A 358
SER A  99
 None
 0.90A 4lrhD-1hlgA:
0.0		 4lrhD-1hlgA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 HIS A 151
TRP A 106
SER A 266
 None
 1.15A 4lrhD-1hplA:
0.0		 4lrhD-1hplA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdi L-RIBULOSE 5
PHOSPHATE
4-EPIMERASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		3 HIS A  80
TRP A 176
SER A  74
 None
 0.84A 4lrhD-1jdiA:
undetectable		 4lrhD-1jdiA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqg CARBOXYPEPTIDASE A

(Helicoverpa
armigera) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		3 HIS A  13
TRP A  73
SER A   2
 None
 1.18A 4lrhD-1jqgA:
undetectable		 4lrhD-1jqgA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC

(Canis lupus) 		PF00561
(Abhydrolase_1) 		3 HIS A  65
TRP A 358
SER A  99
 None
 1.06A 4lrhD-1k8qA:
undetectable		 4lrhD-1k8qA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		3 HIS A 223
TRP A 295
SER A 304
 None
 1.14A 4lrhD-1kcxA:
undetectable		 4lrhD-1kcxA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 328
TRP A 326
SER A 354
 CU  A 630 (-3.2A)
None
None
 1.20A 4lrhD-1llaA:
undetectable		 4lrhD-1llaA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 HIS B 151
TRP B 106
SER B 266
 MUP  B 901 (-4.5A)
None
None
 1.14A 4lrhD-1lpbB:
undetectable		 4lrhD-1lpbB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		3 HIS A 407
TRP A 409
SER A 368
 None
HEM  A 750 (-3.4A)
None
 1.22A 4lrhD-1lzxA:
undetectable		 4lrhD-1lzxA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		3 HIS A 309
TRP A 216
SER A   7
 None
 1.19A 4lrhD-1m2pA:
undetectable		 4lrhD-1m2pA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		3 HIS A 222
TRP A 161
SER A 124
 None
 1.23A 4lrhD-1mqtA:
undetectable		 4lrhD-1mqtA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 HIS N 312
TRP N 265
SER N 314
 None
 1.22A 4lrhD-1nmbN:
undetectable		 4lrhD-1nmbN:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otw COENZYME PQQ
SYNTHESIS PROTEIN C

(Klebsiella
pneumoniae) 		PF03070
(TENA_THI-4) 		3 HIS A  30
TRP A 219
SER A 156
 None
 1.18A 4lrhD-1otwA:
undetectable		 4lrhD-1otwA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE

(Enterococcus
faecium) 		PF01427
(Peptidase_M15) 		3 HIS A 184
TRP A 182
SER A 115
 ZN  A 203 (-3.5A)
None
None
 1.05A 4lrhD-1r44A:
undetectable		 4lrhD-1r44A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umi F-BOX ONLY PROTEIN 2

(Mus musculus) 		PF04300
(FBA) 		3 HIS A 272
TRP A 179
SER A 291
 None
 1.08A 4lrhD-1umiA:
undetectable		 4lrhD-1umiA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 HIS A  65
TRP A  94
SER A  45
 ZN  A 401 (-3.4A)
None
ZN  A 401 ( 4.2A)
 1.20A 4lrhD-1vj0A:
undetectable		 4lrhD-1vj0A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w52 PANCREATIC LIPASE
RELATED PROTEIN 2

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 HIS X 153
TRP X 108
SER X 268
 None
 1.21A 4lrhD-1w52X:
undetectable		 4lrhD-1w52X:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		3 HIS A 322
TRP A 237
SER A  54
 TAR  A1001 (-3.7A)
None
None
 1.16A 4lrhD-2dw6A:
undetectable		 4lrhD-2dw6A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e32 F-BOX ONLY PROTEIN 2

(Mus musculus) 		PF00646
(F-box)
PF04300
(FBA) 		3 HIS A 272
TRP A 179
SER A 291
 None
 1.10A 4lrhD-2e32A:
undetectable		 4lrhD-2e32A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 HIS A 170
TRP A 125
SER A 284
 None
 1.07A 4lrhD-2pplA:
undetectable		 4lrhD-2pplA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 HIS A 151
TRP A 106
SER A 266
 None
 1.14A 4lrhD-2pvsA:
undetectable		 4lrhD-2pvsA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2d ZN-DEPENDENT
HYDROLASES

(Agrobacterium
fabrum) 		PF00753
(Lactamase_B) 		3 HIS A 116
TRP A  72
SER A 212
 ZN  A 277 ( 3.2A)
None
None
 1.15A 4lrhD-2r2dA:
undetectable		 4lrhD-2r2dA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		3 HIS A 334
TRP A 299
SER A 407
 None
 1.07A 4lrhD-2vrkA:
undetectable		 4lrhD-2vrkA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		3 HIS A 396
TRP A 391
SER A 385
 None
GOL  A 805 (-4.4A)
None
 1.18A 4lrhD-2ww2A:
undetectable		 4lrhD-2ww2A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		3 HIS A 390
TRP A 385
SER A 379
 None
MVL  A 801 (-3.9A)
None
 1.13A 4lrhD-2wzsA:
undetectable		 4lrhD-2wzsA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3avs LYSINE-SPECIFIC
DEMETHYLASE 6A

(Homo sapiens) 		PF02373
(JmjC) 		3 HIS A1226
TRP A1194
SER A1154
 NI  A1503 ( 3.4A)
None
OGA  A1501 (-2.7A)
 1.17A 4lrhD-3avsA:
undetectable		 4lrhD-3avsA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayn RHODOPSIN

(Todarodes
pacificus) 		PF00001
(7tm_1) 		3 HIS A  20
TRP A  12
SER A 192
 None
 1.09A 4lrhD-3aynA:
undetectable		 4lrhD-3aynA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bu7 GENTISATE
1,2-DIOXYGENASE

(Ruegeria
pomeroyi) 		PF07883
(Cupin_2) 		3 HIS A 290
TRP A 327
SER A 252
 FE2  A 500 (-3.5A)
None
None
 1.10A 4lrhD-3bu7A:
undetectable		 4lrhD-3bu7A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		3 HIS A 205
TRP A 277
SER A 286
 None
 1.16A 4lrhD-3dc8A:
undetectable		 4lrhD-3dc8A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 HIS A 167
TRP A 140
SER A 270
 GOL  A 786 (-3.8A)
None
GOL  A 786 (-3.5A)
 1.00A 4lrhD-3dmkA:
undetectable		 4lrhD-3dmkA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		3 HIS X 310
TRP X 217
SER X   8
 None
 1.21A 4lrhD-3e3bX:
undetectable		 4lrhD-3e3bX:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		3 HIS A 214
TRP A  88
SER A 245
 FE  A 502 (-3.6A)
None
None
 1.23A 4lrhD-3g77A:
undetectable		 4lrhD-3g77A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvd PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		3 HIS A 336
TRP A 346
SER A 640
 None
 1.23A 4lrhD-3hvdA:
undetectable		 4lrhD-3hvdA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP1

(Enterovirus B) 		PF00073
(Rhv) 		3 HIS A 161
TRP A 100
SER A  63
 None
 1.11A 4lrhD-3j2jA:
undetectable		 4lrhD-3j2jA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8g GTPASE DER

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		3 HIS X 351
TRP X 323
SER X 367
 None
 1.17A 4lrhD-3j8gX:
undetectable		 4lrhD-3j8gX:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S9,
MITOCHONDRIAL

(Bos taurus) 		PF00380
(Ribosomal_S9) 		3 HIS I 148
TRP I 140
SER I 160
 None
 1.03A 4lrhD-3jd5I:
undetectable		 4lrhD-3jd5I:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 403
TRP A 452
SER A 241
 CU  A 602 (-3.0A)
None
CU  A 604 ( 4.7A)
 1.13A 4lrhD-3kw7A:
undetectable		 4lrhD-3kw7A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12979
(DUF3863)
PF12980
(DUF3864) 		3 HIS A 297
TRP A 342
SER A 217
 None
 0.99A 4lrhD-3lm3A:
undetectable		 4lrhD-3lm3A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msu CITRATE SYNTHASE

(Francisella
tularensis) 		PF00285
(Citrate_synt) 		3 HIS A 228
TRP A 394
SER A 368
 None
 1.15A 4lrhD-3msuA:
undetectable		 4lrhD-3msuA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 HIS A 304
TRP A 225
SER A  53
 None
 1.08A 4lrhD-3ozyA:
undetectable		 4lrhD-3ozyA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stt METHYLKETONE
SYNTHASE I

(Solanum
habrochaites) 		PF12697
(Abhydrolase_6) 		3 HIS A  86
TRP A  24
SER A 111
 None
 0.94A 4lrhD-3sttA:
undetectable		 4lrhD-3sttA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		3 HIS A 336
TRP A 346
SER A 640
 None
 1.00A 4lrhD-3texA:
undetectable		 4lrhD-3texA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		3 HIS A 776
TRP A 780
SER A 637
 None
 0.83A 4lrhD-3v9fA:
undetectable		 4lrhD-3v9fA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
coelicolor) 		PF08241
(Methyltransf_11) 		3 HIS A  50
TRP A 257
SER A 111
 SAH  A 302 ( 3.8A)
None
SAH  A 302 ( 4.1A)
 1.15A 4lrhD-3vc1A:
undetectable		 4lrhD-3vc1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		3 HIS A 303
TRP A 448
SER A 250
 TCG  A 601 (-4.1A)
TCG  A 601 (-4.0A)
None
 1.05A 4lrhD-3vtrA:
undetectable		 4lrhD-3vtrA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyl L-RIBULOSE
3-EPIMERASE

(Mesorhizobium
loti) 		PF01261
(AP_endonuc_2) 		3 HIS A   7
TRP A 263
SER A  64
 None
 1.22A 4lrhD-3vylA:
undetectable		 4lrhD-3vylA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		3 HIS A 339
TRP A 167
SER A 246
 DIA  A 401 (-2.7A)
None
DIA  A 401 (-2.8A)
 1.18A 4lrhD-3wwxA:
undetectable		 4lrhD-3wwxA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a25 FERRITIN DPS FAMILY
PROTEIN

(Kineococcus
radiotolerans) 		PF00210
(Ferritin) 		3 HIS A  41
TRP A  49
SER A  74
 None
 1.08A 4lrhD-4a25A:
undetectable		 4lrhD-4a25A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		3 HIS A 176
TRP A 349
SER A 149
 None
NGO  A1495 ( 3.4A)
None
 1.17A 4lrhD-4c7gA:
undetectable		 4lrhD-4c7gA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 HIS A 223
TRP A 295
SER A 304
 None
 1.14A 4lrhD-4cnsA:
undetectable		 4lrhD-4cnsA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cv5 PROTEIN CAF40

(Saccharomyces
cerevisiae) 		PF04078
(Rcd1) 		3 HIS B 194
TRP B 143
SER B 237
 None
 1.14A 4lrhD-4cv5B:
undetectable		 4lrhD-4cv5B:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B

(Mus musculus) 		PF02373
(JmjC) 		3 HIS A1470
TRP A1438
SER A1398
 NI  A1701 ( 3.1A)
None
OGA  A1700 (-2.8A)
 1.16A 4lrhD-4eyuA:
undetectable		 4lrhD-4eyuA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
lasaliensis) 		PF02353
(CMAS) 		3 HIS A  58
TRP A 265
SER A 119
 None
 1.17A 4lrhD-4f85A:
undetectable		 4lrhD-4f85A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbd PUTATIVE
UNCHARACTERIZED
PROTEIN

(Toxoplasma
gondii) 		PF11539
(DUF3228) 		3 HIS A  76
TRP A 165
SER A 178
 None
 1.07A 4lrhD-4fbdA:
undetectable		 4lrhD-4fbdA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6b CITRATE SYNTHASE

(Escherichia
coli) 		PF00285
(Citrate_synt) 		3 HIS A 226
TRP A 391
SER A 365
 None
 1.07A 4lrhD-4g6bA:
undetectable		 4lrhD-4g6bA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhv COLLAGEN TYPE IV
ALPHA-3-BINDING
PROTEIN

(Homo sapiens) 		PF00169
(PH) 		3 HIS A 115
TRP A 108
SER A 119
 None
GOL  A 202 ( 4.0A)
None
 1.23A 4lrhD-4hhvA:
undetectable		 4lrhD-4hhvA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Mycobacterium
tuberculosis) 		PF02126
(PTE) 		3 HIS A  22
TRP A 284
SER A 176
 ZN  A 401 (-3.4A)
None
None
 1.16A 4lrhD-4if2A:
undetectable		 4lrhD-4if2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 HIS A 348
TRP A 255
SER A   7
 None
 1.21A 4lrhD-4jr7A:
undetectable		 4lrhD-4jr7A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2a HALOALKANE
DEHALOGENASE

(Bradyrhizobium
elkanii) 		PF00561
(Abhydrolase_1) 		3 HIS A 139
TRP A 135
SER A 175
 None
 1.21A 4lrhD-4k2aA:
undetectable		 4lrhD-4k2aA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kem MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azospirillum
lipoferum) 		PF13378
(MR_MLE_C) 		3 HIS A 321
TRP A 236
SER A  52
 AKR  A 405 (-4.6A)
None
None
 1.18A 4lrhD-4kemA:
undetectable		 4lrhD-4kemA:
19.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kmz FOLATE RECEPTOR BETA

(Homo sapiens) 		PF03024
(Folate_rec) 		3 HIS A 151
TRP A 156
SER A 190
 FOL  A 301 (-3.9A)
FOL  A 301 (-3.7A)
FOL  A 301 (-2.6A)
 0.24A 4lrhD-4kmzA:
34.8		 4lrhD-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lrh FOLATE RECEPTOR
ALPHA

(Homo sapiens) 		PF03024
(Folate_rec) 		3 HIS A 135
TRP A 140
SER A 174
 FOL  A 301 (-4.1A)
FOL  A 301 (-3.6A)
FOL  A 301 (-2.8A)
 0.17A 4lrhD-4lrhA:
37.2		 4lrhD-4lrhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		3 HIS E 309
TRP E 216
SER E   7
 None
 1.21A 4lrhD-4md8E:
undetectable		 4lrhD-4md8E:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A
TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN E

(Pseudomonas
mendocina;
Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox)
PF02332
(Phenol_Hydrox) 		3 HIS B 165
TRP A   9
SER B 253
 None
 1.19A 4lrhD-4p1cB:
undetectable		 4lrhD-4p1cB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE

(Escherichia
coli) 		PF06315
(AceK) 		3 HIS A 468
TRP A 425
SER A 247
 None
 1.09A 4lrhD-4p69A:
undetectable		 4lrhD-4p69A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7w L-PROLINE
CIS-4-HYDROXYLASE

(Mesorhizobium
japonicum) 		PF05118
(Asp_Arg_Hydrox)
PF05373
(Pro_3_hydrox_C) 		3 HIS A 231
TRP A 200
SER A 155
 None
 1.01A 4lrhD-4p7wA:
undetectable		 4lrhD-4p7wA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		3 HIS A 126
TRP A 249
SER A 130
 None
 1.10A 4lrhD-4r27A:
undetectable		 4lrhD-4r27A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqt D-HYDANTOINASE

(Brucella suis) 		PF01979
(Amidohydro_1) 		3 HIS A 209
TRP A 281
SER A 290
 None
 1.22A 4lrhD-4tqtA:
undetectable		 4lrhD-4tqtA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tuf MAJOR EXTRACELLULAR
ENDOGLUCANASE

(Xanthomonas
campestris) 		PF00150
(Cellulase) 		3 HIS A  60
TRP A 337
SER A  99
 None
 1.21A 4lrhD-4tufA:
undetectable		 4lrhD-4tufA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		PF00145
(DNA_methylase) 		3 HIS A 506
TRP A 601
SER A 496
 None
 1.15A 4lrhD-4u7tA:
undetectable		 4lrhD-4u7tA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw7 L-SHAPED TAIL FIBER
PROTEIN

(Escherichia
virus T5) 		no annotation 3 HIS A1043
TRP A1058
SER A1038
 None
 1.12A 4lrhD-4uw7A:
undetectable		 4lrhD-4uw7A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ww3 RHODOPSIN

(Todarodes
pacificus) 		PF00001
(7tm_1) 		3 HIS A  20
TRP A  12
SER A 192
 None
 1.15A 4lrhD-4ww3A:
undetectable		 4lrhD-4ww3A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN SEH1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 HIS C  13
TRP C 308
SER C  57
 None
 1.14A 4lrhD-4xmmC:
undetectable		 4lrhD-4xmmC:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE

(Streptomyces
globisporus) 		PF00668
(Condensation) 		3 HIS A 154
TRP A 241
SER A 306
 4T7  A 501 (-4.1A)
SUC  A 502 (-4.5A)
None
 0.99A 4lrhD-4zxwA:
undetectable		 4lrhD-4zxwA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbj FADH2-DEPENDENT
HALOGENASE PLTA

(Pseudomonas
protegens) 		no annotation 3 HIS E 229
TRP E 237
SER E 215
 None
 0.90A 4lrhD-5dbjE:
undetectable		 4lrhD-5dbjE:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		3 HIS A 484
TRP A 554
SER A 521
 None
TRS  A1001 (-4.9A)
None
 1.19A 4lrhD-5dkxA:
undetectable		 4lrhD-5dkxA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		3 HIS A 449
TRP A 339
SER A 204
 None
 1.12A 4lrhD-5fv4A:
undetectable		 4lrhD-5fv4A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE

(Synechococcus
elongatus) 		PF02782
(FGGY_C) 		3 HIS A 265
TRP A 271
SER A  72
 None
 1.09A 4lrhD-5htpA:
undetectable		 4lrhD-5htpA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htv PUTATIVE XYLULOSE
KINASE

(Arabidopsis
thaliana) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 HIS A 280
TRP A 286
SER A  86
 None
 1.22A 4lrhD-5htvA:
undetectable		 4lrhD-5htvA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA

(Mus musculus) 		PF01532
(Glyco_hydro_47) 		3 HIS A 407
TRP A 464
SER A 343
 None
 1.21A 4lrhD-5kkbA:
undetectable		 4lrhD-5kkbA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		3 HIS A 594
TRP A 602
SER A 315
 None
None
CSO  A 316 ( 4.3A)
 0.99A 4lrhD-5mfaA:
undetectable		 4lrhD-5mfaA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		3 HIS A 315
TRP A 290
SER A 625
 AMP  A1201 (-4.6A)
None
None
 0.88A 4lrhD-5mswA:
undetectable		 4lrhD-5mswA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 3 HIS B 686
TRP B 273
SER B 684
 None
 0.93A 4lrhD-5nd1B:
undetectable		 4lrhD-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4

(Homo sapiens) 		no annotation 3 HIS A 223
TRP A 295
SER A 304
 HIS  A 223 ( 1.0A)
TRP  A 295 ( 0.5A)
SER  A 304 ( 0.0A)
 1.18A 4lrhD-5nksA:
undetectable		 4lrhD-5nksA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		3 HIS A 317
TRP A 546
SER A 721
 None
 1.18A 4lrhD-5svcA:
undetectable		 4lrhD-5svcA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w16 GLUTAMATE RACEMASE

(Thermus
thermophilus) 		no annotation 3 HIS A 178
TRP A 149
SER A  13
 DGL  A 301 ( 3.9A)
None
DGL  A 301 (-2.6A)
 1.17A 4lrhD-5w16A:
undetectable		 4lrhD-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x55 PROBABLE URACIL-DNA
GLYCOSYLASE

(Acanthamoeba
polyphaga
mimivirus) 		PF03167
(UDG) 		3 HIS A 350
TRP A 368
SER A 316
 None
 1.03A 4lrhD-5x55A:
undetectable		 4lrhD-5x55A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykd D-HYDANTOINASE/DIHYD
ROPYRIMIDINASE

(Pseudomonas
aeruginosa) 		no annotation 3 HIS A 208
TRP A 280
SER A 289
 None
 1.16A 4lrhD-5ykdA:
undetectable		 4lrhD-5ykdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6any BM4233, ISOFORM B

(Brugia malayi) 		no annotation 3 HIS A 181
TRP A  67
SER A  87
 None
 1.14A 4lrhD-6anyA:
undetectable		 4lrhD-6anyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 3 HIS A 594
TRP A 602
SER A 315
 None
None
CSO  A 316 ( 4.4A)
 1.06A 4lrhD-6azpA:
undetectable		 4lrhD-6azpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 3 HIS A 622
TRP A 261
SER A 417
 None
 0.71A 4lrhD-6bhuA:
undetectable		 4lrhD-6bhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch0 -

(-) 		no annotation 3 HIS C 123
TRP C  79
SER C 219
 CO  C 301 (-3.3A)
None
None
 1.20A 4lrhD-6ch0C:
undetectable		 4lrhD-6ch0C:
undetectable