SIMILAR PATTERNS OF AMINO ACIDS FOR 4LRH_B_FOLB301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kmz FOLATE RECEPTOR BETA

(Homo sapiens) 		PF03024
(Folate_rec) 		11 TYR A  76
TYR A 101
GLN A 116
SER A 117
ARG A 119
ARG A 122
HIS A 151
TRP A 154
TRP A 156
TRP A 187
TYR A 191
 FOL  A 301 (-3.8A)
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-3.5A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
None
FOL  A 301 (-3.7A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.1A)
 0.66A 4lrhB-4kmzA:
35.3		 4lrhB-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kmz FOLATE RECEPTOR BETA

(Homo sapiens) 		PF03024
(Folate_rec) 		5 TYR A 101
ARG A 119
ARG A 122
HIS A 151
TRP A 150
 FOL  A 301 (-3.8A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
None
 1.28A 4lrhB-4kmzA:
35.3		 4lrhB-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lrh FOLATE RECEPTOR
ALPHA

(Homo sapiens) 		PF03024
(Folate_rec) 		6 GLN A 100
ARG A 106
HIS A 135
LYS A 136
TRP A 138
TRP A 171
 FOL  A 301 (-4.3A)
FOL  A 301 (-3.8A)
FOL  A 301 (-4.1A)
FOL  A 301 (-4.0A)
None
FOL  A 301 (-3.7A)
 1.39A 4lrhB-4lrhA:
37.0		 4lrhB-4lrhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lrh FOLATE RECEPTOR
ALPHA

(Homo sapiens) 		PF03024
(Folate_rec) 		12 TYR A  60
TYR A  85
GLN A 100
SER A 101
ARG A 103
ARG A 106
HIS A 135
LYS A 136
TRP A 138
TRP A 140
TRP A 171
TYR A 175
 FOL  A 301 (-3.9A)
FOL  A 301 (-4.1A)
FOL  A 301 (-4.3A)
FOL  A 301 (-3.5A)
FOL  A 301 (-3.2A)
FOL  A 301 (-3.8A)
FOL  A 301 (-4.1A)
FOL  A 301 (-4.0A)
None
FOL  A 301 (-3.6A)
FOL  A 301 (-3.7A)
FOL  A 301 (-4.1A)
 0.58A 4lrhB-4lrhA:
37.0		 4lrhB-4lrhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lrh FOLATE RECEPTOR
ALPHA

(Homo sapiens) 		PF03024
(Folate_rec) 		5 TYR A  85
ARG A 103
ARG A 106
HIS A 135
TRP A 134
 FOL  A 301 (-4.1A)
FOL  A 301 (-3.2A)
FOL  A 301 (-3.8A)
FOL  A 301 (-4.1A)
None
 1.28A 4lrhB-4lrhA:
37.0		 4lrhB-4lrhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		3 ASP A 139
TRP A 446
SER A  93
 None
 0.88A 4lrhB-1cbgA:
0.0		 4lrhB-1cbgA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		3 ASP M 143
TRP M 457
SER M  97
 None
GOL  M 936 (-3.7A)
None
 1.02A 4lrhB-1dwaM:
0.0		 4lrhB-1dwaM:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis aries) 		PF00089
(Trypsin) 		3 ASP A 102
TRP A  63
SER A 195
 None
None
PBZ  A 305 (-2.9A)
 1.06A 4lrhB-1fiwA:
undetectable		 4lrhB-1fiwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		3 ASP A 102
TRP A  63
SER A 195
 None
None
PBZ  A 308 (-3.2A)
 1.07A 4lrhB-1fizA:
undetectable		 4lrhB-1fizA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3m ESTROGEN
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 ASP A 121
TRP A 178
SER A 184
 None
 1.01A 4lrhB-1g3mA:
0.0		 4lrhB-1g3mA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 ASP A 340
TRP A 299
SER A 268
 None
 0.74A 4lrhB-1hwwA:
0.0		 4lrhB-1hwwA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		3 ASP A 139
TRP A 452
SER A  93
 None
 1.02A 4lrhB-1hxjA:
0.0		 4lrhB-1hxjA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 ASP B 536
TRP B 897
SER B 870
 None
 1.04A 4lrhB-1m2vB:
0.0		 4lrhB-1m2vB:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5f SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 ASP H 102
TRP H  65
SER H 195
 None
None
CR9  H 256 (-1.5A)
 1.06A 4lrhB-1o5fH:
0.0		 4lrhB-1o5fH:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 ASP A 536
TRP A 897
SER A 870
 None
 0.95A 4lrhB-1pd1A:
undetectable		 4lrhB-1pd1A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhf PROTEIN
(PHOSPHOGLYCERATE
MUTASE)

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		3 ASP A  91
TRP A  13
SER A 127
 None
 0.98A 4lrhB-1qhfA:
undetectable		 4lrhB-1qhfA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans) 		PF00232
(Glyco_hydro_1) 		3 ASP A 123
TRP A 402
SER A  79
 None
 1.02A 4lrhB-1qoxA:
undetectable		 4lrhB-1qoxA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qz9 KYNURENINASE

(Pseudomonas
fluorescens) 		PF00266
(Aminotran_5) 		3 ASP A  95
TRP A  64
SER A  73
 None
 1.05A 4lrhB-1qz9A:
undetectable		 4lrhB-1qz9A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgq STREPTOMYCES GRISEUS
PROTEINASE B

(Streptomyces
griseus) 		PF00089
(Trypsin) 		3 ASP E 102
TRP E  66
SER E 195
 None
 1.01A 4lrhB-1sgqE:
undetectable		 4lrhB-1sgqE:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr1 BETA-GLUCOSIDASE A

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		3 ASP A 123
TRP A 398
SER A  79
 None
GOL  A2000 (-3.2A)
None
 1.07A 4lrhB-1tr1A:
undetectable		 4lrhB-1tr1A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		3 ASP A 145
TRP A 453
SER A  99
 None
 1.02A 4lrhB-1v02A:
undetectable		 4lrhB-1v02A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbr ENDO-1,4-BETA-XYLANA
SE B

(Thermotoga
maritima) 		PF00331
(Glyco_hydro_10) 		3 ASP A 651
TRP A 802
SER A 691
 None
XYS  A   1 ( 4.0A)
None
 1.04A 4lrhB-1vbrA:
undetectable		 4lrhB-1vbrA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae) 		PF00232
(Glyco_hydro_1) 		3 ASP A 124
TRP A 416
SER A  79
 None
GOL  A1465 (-3.5A)
None
 1.01A 4lrhB-1wcgA:
undetectable		 4lrhB-1wcgA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE

(Chlorobaculum
tepidum) 		PF04371
(PAD_porph) 		3 ASP A 133
TRP A  29
SER A  21
 None
 1.01A 4lrhB-1xknA:
undetectable		 4lrhB-1xknA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE

(Oryctolagus
cuniculus) 		PF03071
(GNT-I) 		3 ASP A 245
TRP A 290
SER A 241
 None
 0.97A 4lrhB-2am4A:
undetectable		 4lrhB-2am4A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 ASP A 133
TRP A 214
SER A 202
 None
 0.99A 4lrhB-2e1bA:
undetectable		 4lrhB-2e1bA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		3 ASP A 125
TRP A 415
SER A  79
 None
 1.01A 4lrhB-2e3zA:
undetectable		 4lrhB-2e3zA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf7 CLASS B ACID
PHOSPHATASE

(Escherichia
coli) 		PF03767
(Acid_phosphat_B) 		3 ASP A  44
TRP A  77
SER A  52
 MG  A 700 ( 2.5A)
None
None
 0.91A 4lrhB-2hf7A:
undetectable		 4lrhB-2hf7A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		3 ASP A  54
TRP A  29
SER A 148
 None
 0.76A 4lrhB-2j3zA:
undetectable		 4lrhB-2j3zA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		3 ASP A 123
TRP A 398
SER A  79
 None
IDE  A1446 (-3.6A)
None
 0.95A 4lrhB-2j7cA:
undetectable		 4lrhB-2j7cA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9r BETA-GLUCOSIDASE B

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		3 ASP A 124
TRP A 402
SER A  81
 None
TCB  A 500 ( 3.6A)
None
 0.93A 4lrhB-2o9rA:
undetectable		 4lrhB-2o9rA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		3 ASP A 118
TRP A 421
SER A  74
 None
 1.01A 4lrhB-2pbgA:
undetectable		 4lrhB-2pbgA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ASP A 210
TRP A  34
SER A 182
 CA  A 478 (-3.2A)
None
None
 1.02A 4lrhB-2pplA:
undetectable		 4lrhB-2pplA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vra ROUNDABOUT 1

(Drosophila
melanogaster) 		PF07679
(I-set) 		3 ASP A 163
TRP A 189
SER A 245
 None
 0.99A 4lrhB-2vraA:
undetectable		 4lrhB-2vraA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		3 ASP A 368
TRP A 275
SER A 364
 SN5  A1567 ( 4.8A)
SN5  A1566 (-3.3A)
SN5  A1567 ( 4.4A)
 0.99A 4lrhB-2wk2A:
undetectable		 4lrhB-2wk2A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		3 ASP A 528
TRP A 348
SER A 569
 None
 1.04A 4lrhB-2ymuA:
undetectable		 4lrhB-2ymuA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zch MONOCLONAL ANTIBODY
8G8F5 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASP H  10
TRP H  36
SER H   7
 None
 1.00A 4lrhB-2zchH:
undetectable		 4lrhB-2zchH:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyi LIPASE, PUTATIVE

(Archaeoglobus
fulgidus) 		PF00561
(Abhydrolase_1) 		3 ASP A 115
TRP A  65
SER A 148
 None
 0.84A 4lrhB-2zyiA:
undetectable		 4lrhB-2zyiA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		3 ASP A 121
TRP A 417
SER A  75
 None
TRS  A 500 ( 4.1A)
None
 0.99A 4lrhB-3ahyA:
undetectable		 4lrhB-3ahyA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csq MORPHOGENESIS
PROTEIN 1

(Bacillus virus
phi29) 		no annotation 3 ASP A 195
TRP A 292
SER A 187
 ZN  A 335 (-2.1A)
None
ZN  A 335 ( 4.2A)
 1.03A 4lrhB-3csqA:
undetectable		 4lrhB-3csqA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A 181
TRP A 543
SER A 142
 NAG  A 710 ( 3.4A)
None
None
 1.04A 4lrhB-3dkhA:
undetectable		 4lrhB-3dkhA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A 181
TRP A 547
SER A 142
 NAG  A 710 ( 3.4A)
None
None
 0.81A 4lrhB-3dkhA:
undetectable		 4lrhB-3dkhA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4d ESTERASE D

(Agrobacterium
fabrum) 		PF00756
(Esterase) 		3 ASP A 223
TRP A  95
SER A 147
 CL  A 280 ( 4.7A)
None
CL  A 279 (-2.9A)
 0.75A 4lrhB-3e4dA:
undetectable		 4lrhB-3e4dA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		3 ASP A 617
TRP A 669
SER A 673
 None
 1.04A 4lrhB-3gitA:
undetectable		 4lrhB-3gitA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnr OS03G0212800 PROTEIN

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 ASP A 134
TRP A 444
SER A  90
 ASP  A 134 ( 0.6A)
TRP  A 444 (-0.5A)
SER  A  90 ( 0.0A)
 0.94A 4lrhB-3gnrA:
undetectable		 4lrhB-3gnrA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj6 FRUCTOKINASE

(Halothermothrix
orenii) 		PF00294
(PfkB) 		3 ASP A 129
TRP A 122
SER A 156
 None
 0.88A 4lrhB-3hj6A:
undetectable		 4lrhB-3hj6A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om8 PROBABLE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		3 ASP A 217
TRP A 134
SER A  99
 None
None
EDO  A 266 (-2.7A)
 0.74A 4lrhB-3om8A:
undetectable		 4lrhB-3om8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A 182
TRP A 552
SER A 143
 NAG  A 700 (-3.5A)
None
None
 0.78A 4lrhB-3ppsA:
undetectable		 4lrhB-3ppsA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 ASP A 135
TRP A 442
SER A  89
 None
TRS  A1164 (-3.6A)
None
 0.99A 4lrhB-3ptkA:
undetectable		 4lrhB-3ptkA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 280
TRP A 344
SER A  54
 None
 1.03A 4lrhB-3t9pA:
undetectable		 4lrhB-3t9pA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
paradoxus) 		PF02335
(Cytochrom_C552) 		3 ASP A 161
TRP A 208
SER A 167
 None
 1.06A 4lrhB-3ttbA:
undetectable		 4lrhB-3ttbA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		3 ASP A 142
TRP A 469
SER A  96
 None
 0.98A 4lrhB-3u5uA:
undetectable		 4lrhB-3u5uA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 ASP A  86
TRP A 360
SER A 374
 None
 1.05A 4lrhB-3uszA:
undetectable		 4lrhB-3uszA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		3 ASP A 150
TRP A 444
SER A 105
 None
SA0  A 507 (-3.7A)
None
 1.02A 4lrhB-3vilA:
undetectable		 4lrhB-3vilA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w53 BETA-GLUCOSIDASE

(Micrococcus
antarcticus) 		PF00232
(Glyco_hydro_1) 		3 ASP A 127
TRP A 424
SER A  84
 None
TRS  A 501 ( 4.1A)
None
 0.91A 4lrhB-3w53A:
undetectable		 4lrhB-3w53A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 3 ASP A 435
TRP A  85
SER A   4
 None
 0.91A 4lrhB-3wevA:
undetectable		 4lrhB-3wevA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh7 BETA-GLUCOSIDASE

(metagenomes) 		PF00232
(Glyco_hydro_1) 		3 ASP A 123
TRP A 399
SER A  79
 None
FCB  A 501 (-3.6A)
None
 1.00A 4lrhB-3wh7A:
undetectable		 4lrhB-3wh7A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq4 BETA-PRIMEVEROSIDASE

(Camellia
sinensis) 		PF00232
(Glyco_hydro_1) 		3 ASP A 159
TRP A 463
SER A 113
 None
 0.99A 4lrhB-3wq4A:
undetectable		 4lrhB-3wq4A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwp (S)-HYDROXYNITRILE
LYASE

(Baliospermum
montanum) 		PF00561
(Abhydrolase_1) 		3 ASP A 207
TRP A 128
SER A  80
 None
EDO  A 305 (-4.7A)
EDO  A 302 (-3.3A)
 1.01A 4lrhB-3wwpA:
undetectable		 4lrhB-3wwpA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		3 ASP A 121
TRP A 385
SER A  77
 None
GOL  A 902 (-3.8A)
None
 1.01A 4lrhB-3zjkA:
undetectable		 4lrhB-3zjkA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		3 ASP A 121
TRP A 416
SER A  76
 None
 0.98A 4lrhB-4b3kA:
undetectable		 4lrhB-4b3kA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 ASP A  92
TRP A  53
SER A 187
 None
 0.94A 4lrhB-4dgjA:
undetectable		 4lrhB-4dgjA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etm LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE YFKJ

(Bacillus
subtilis) 		PF01451
(LMWPc) 		3 ASP A  89
TRP A  45
SER A  95
 None
 0.90A 4lrhB-4etmA:
undetectable		 4lrhB-4etmA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9d POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF01522
(Polysacc_deac_1)
PF14883
(GHL13) 		3 ASP A 229
TRP A 167
SER A 183
 None
 1.03A 4lrhB-4f9dA:
undetectable		 4lrhB-4f9dA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4geq KINETOCHORE PROTEIN
SPC25
KINETOCHORE PROTEIN
SPC24

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
PF08286
(Spc24) 		3 ASP A 205
TRP B 208
SER B 167
 None
 0.83A 4lrhB-4geqA:
undetectable		 4lrhB-4geqA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN

(Thermotoga
maritima;
Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		3 ASP A 130
TRP A 419
SER A  86
 None
 0.82A 4lrhB-4gxpA:
undetectable		 4lrhB-4gxpA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		3 ASP A 160
TRP A 434
SER A 116
 None
BGC  A 501 (-3.6A)
None
 1.02A 4lrhB-4hz8A:
undetectable		 4lrhB-4hz8A:
17.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kmz FOLATE RECEPTOR BETA

(Homo sapiens) 		PF03024
(Folate_rec) 		3 ASP A  97
TRP A 118
SER A 190
 FOL  A 301 (-2.8A)
FOL  A 301 (-4.0A)
FOL  A 301 (-2.6A)
 0.57A 4lrhB-4kmzA:
35.3		 4lrhB-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lrh FOLATE RECEPTOR
ALPHA

(Homo sapiens) 		PF03024
(Folate_rec) 		3 ASP A  81
TRP A 102
SER A 174
 FOL  A 301 (-2.7A)
FOL  A 301 (-4.2A)
FOL  A 301 (-2.8A)
 0.55A 4lrhB-4lrhA:
37.0		 4lrhB-4lrhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		3 ASP A 122
TRP A 427
SER A  76
 None
GOL  A 507 (-3.5A)
None
 1.01A 4lrhB-4mdpA:
undetectable		 4lrhB-4mdpA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Alicyclobacillus
acidocaldarius) 		PF13416
(SBP_bac_8) 		3 ASP A 270
TRP A 244
SER A 277
 None
 1.07A 4lrhB-4ovjA:
undetectable		 4lrhB-4ovjA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptx GLYCOSIDE HYDROLASE
FAMILY 1

(Halothermothrix
orenii) 		PF00232
(Glyco_hydro_1) 		3 ASP A 123
TRP A 401
SER A  79
 None
BGC  A 501 (-3.6A)
None
 0.98A 4lrhB-4ptxA:
undetectable		 4lrhB-4ptxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2b ENDO-1,4-BETA-D-GLUC
ANASE

(Pseudomonas
putida) 		PF01270
(Glyco_hydro_8) 		3 ASP A 167
TRP A 198
SER A 115
 None
 0.78A 4lrhB-4q2bA:
undetectable		 4lrhB-4q2bA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlj BETA-GLUCOSIDASE 7

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 ASP A 132
TRP A 433
SER A  88
 None
CTT  A1001 (-3.5A)
None
 0.99A 4lrhB-4qljA:
undetectable		 4lrhB-4qljA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 ASP A 135
TRP A 436
SER A  91
 None
MVL  A 501 (-3.7A)
None
 0.96A 4lrhB-4re2A:
undetectable		 4lrhB-4re2A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1

(Populus tremula
x Populus
tremuloides) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 ASP A 106
TRP A 196
SER A 114
 None
 1.02A 4lrhB-4ri6A:
undetectable		 4lrhB-4ri6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)

(Agrobacterium
vitis) 		PF01547
(SBP_bac_1) 		3 ASP A  34
TRP A 260
SER A 268
 None
 0.85A 4lrhB-4ryaA:
undetectable		 4lrhB-4ryaA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xv0 BETA-XYLANASE

(Trichoderma
reesei) 		PF00331
(Glyco_hydro_10) 		3 ASP A  68
TRP A 132
SER A  98
 None
 0.93A 4lrhB-4xv0A:
undetectable		 4lrhB-4xv0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		3 ASP B 338
TRP B 523
SER B 370
 None
 0.89A 4lrhB-4yg8B:
undetectable		 4lrhB-4yg8B:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda) 		PF00232
(Glyco_hydro_1) 		3 ASP A 144
TRP A 444
SER A  99
 None
TRS  A 603 ( 4.2A)
None
 0.98A 4lrhB-5cg0A:
undetectable		 4lrhB-5cg0A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmc ML032222A IGLUR

(Mnemiopsis
leidyi) 		PF10613
(Lig_chan-Glu_bd) 		3 ASP A 187
TRP A 245
SER A  17
 None
 0.95A 4lrhB-5cmcA:
undetectable		 4lrhB-5cmcA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		3 ASP A 359
TRP A 265
SER A 355
 None
NAG  A 603 ( 3.9A)
None
 0.89A 4lrhB-5df0A:
undetectable		 4lrhB-5df0A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 ASP A 102
TRP A  65
SER A 195
 None
 0.94A 4lrhB-5f8zA:
undetectable		 4lrhB-5f8zA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF03071
(GNT-I)
PF15711
(ILEI) 		3 ASP A 427
TRP A 475
SER A 423
 None
 1.00A 4lrhB-5gggA:
undetectable		 4lrhB-5gggA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnx BETA-GLUCOSIDASE

(metagenome) 		PF00232
(Glyco_hydro_1) 		3 ASP A 128
TRP A 405
SER A  84
 None
BGC  A 502 (-3.7A)
None
 1.07A 4lrhB-5gnxA:
undetectable		 4lrhB-5gnxA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		3 ASP A 361
TRP A 268
SER A 357
 ASP  A 361 ( 0.5A)
TRP  A 268 ( 0.5A)
SER  A 357 ( 0.0A)
 0.78A 4lrhB-5gprA:
undetectable		 4lrhB-5gprA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus) 		no annotation 3 ASP A 102
TRP A  65
SER A 195
 None
 0.98A 4lrhB-5gvtA:
undetectable		 4lrhB-5gvtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hk8 PROBABLE
PHEOPHORBIDASE

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		3 ASP A 211
TRP A 136
SER A  87
 None
 1.02A 4lrhB-5hk8A:
undetectable		 4lrhB-5hk8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		3 ASP A 121
TRP A 396
SER A  77
 None
ACT  A 501 (-3.4A)
None
 0.98A 4lrhB-5idiA:
undetectable		 4lrhB-5idiA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipy FLAVIN-CONTAINING
MONOOXYGENASE

(Roseovarius
nubinhibens) 		PF00743
(FMO-like) 		3 ASP A 317
TRP A 401
SER A 206
 None
None
NAP  A 501 (-2.8A)
 0.95A 4lrhB-5ipyA:
undetectable		 4lrhB-5ipyA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		3 ASP A 122
TRP A 417
SER A  76
 None
GOL  A 501 (-3.9A)
None
 1.05A 4lrhB-5jbkA:
undetectable		 4lrhB-5jbkA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		3 ASP A 127
TRP A 434
SER A  81
 None
 1.06A 4lrhB-5jboA:
undetectable		 4lrhB-5jboA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5naq BETA-GALACTOSIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		3 ASP A 121
TRP A 415
SER A  76
 None
 1.05A 4lrhB-5naqA:
undetectable		 4lrhB-5naqA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 3 ASP A 121
TRP A 395
SER A  77
 None
NOJ  A 506 (-3.2A)
None
 1.03A 4lrhB-5ns8A:
undetectable		 4lrhB-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		3 ASP A 545
TRP A 673
SER A 458
 None
 0.98A 4lrhB-5o0sA:
undetectable		 4lrhB-5o0sA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogz -

(-) 		no annotation 3 ASP A 123
TRP A 402
SER A  79
 None
 0.99A 4lrhB-5ogzA:
undetectable		 4lrhB-5ogzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1

(synthetic
construct) 		no annotation 3 ASP A 207
TRP A 128
SER A  80
 None
None
GOL  A 300 (-2.8A)
 0.96A 4lrhB-5tdxA:
undetectable		 4lrhB-5tdxA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 3 ASP A 424
TRP A 408
SER A 420
 None
 1.01A 4lrhB-5veuA:
undetectable		 4lrhB-5veuA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi4 INTERLEUKIN-33
INTERLEUKIN-1
RECEPTOR-LIKE 1

(Mus musculus;
Mus musculus) 		PF15095
(IL33)
PF13895
(Ig_2) 		3 ASP A 145
TRP B  54
SER B  30
 None
 0.95A 4lrhB-5vi4A:
undetectable		 4lrhB-5vi4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wka BETA-GLUCOSIDASE

(metagenome) 		no annotation 3 ASP A 119
TRP A 416
SER A  75
 None
GOL  A 501 (-3.8A)
None
 0.99A 4lrhB-5wkaA:
undetectable		 4lrhB-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgz BETA-GLYCOSIDASE

(uncultured
microorganism) 		no annotation 3 ASP A 127
TRP A 403
SER A  83
 None
GOL  A 501 (-3.5A)
None
 1.08A 4lrhB-5xgzA:
undetectable		 4lrhB-5xgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi UNCHARACTERIZED
PROTEIN
RIBOSOMAL PROTEIN
S15A

(Trichomonas
vaginalis;
Trichomonas
vaginalis) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C)
PF00410
(Ribosomal_S8) 		3 ASP W 112
TRP C 245
SER W  43
 None
 0.97A 4lrhB-5xyiW:
undetectable		 4lrhB-5xyiW:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII

(Homo sapiens) 		no annotation 3 ASP B 102
TRP B  37
SER B 195
 None
None
SO4  B 304 ( 2.5A)
 0.83A 4lrhB-6b74B:
undetectable		 4lrhB-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cuf


(;
) 		no annotation
no annotation 		3 ASP 5  56
TRP 6  91
SER 5  35
 None
 0.97A 4lrhB-6cuf5:
undetectable		 4lrhB-6cuf5:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cuf


(;
) 		no annotation
no annotation 		3 ASP 5  56
TRP 6  96
SER 5  35
 None
 0.97A 4lrhB-6cuf5:
undetectable		 4lrhB-6cuf5:
undetectable