SIMILAR PATTERNS OF AMINO ACIDS FOR 4LRH_A_FOLA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kmz FOLATE RECEPTOR BETA

(Homo sapiens) 		PF03024
(Folate_rec) 		11 TYR A  76
TYR A 101
GLN A 116
SER A 117
TRP A 118
ARG A 119
ARG A 122
HIS A 151
TRP A 154
TRP A 187
TYR A 191
 FOL  A 301 (-3.8A)
FOL  A 301 (-3.8A)
FOL  A 301 ( 4.8A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.0A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
None
FOL  A 301 (-3.5A)
FOL  A 301 (-4.1A)
 0.47A 4lrhA-4kmzA:
35.2		 4lrhA-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kmz FOLATE RECEPTOR BETA

(Homo sapiens) 		PF03024
(Folate_rec) 		5 TYR A 101
ARG A 119
ARG A 122
HIS A 151
TRP A 150
 FOL  A 301 (-3.8A)
FOL  A 301 (-3.0A)
FOL  A 301 ( 4.4A)
FOL  A 301 (-3.9A)
None
 1.45A 4lrhA-4kmzA:
35.2		 4lrhA-4kmzA:
77.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lrh FOLATE RECEPTOR
ALPHA

(Homo sapiens) 		PF03024
(Folate_rec) 		12 TYR A  60
TYR A  85
GLN A 100
SER A 101
TRP A 102
ARG A 103
ARG A 106
HIS A 135
LYS A 136
TRP A 138
TRP A 171
TYR A 175
 FOL  A 301 (-3.9A)
FOL  A 301 (-4.1A)
FOL  A 301 (-4.3A)
FOL  A 301 (-3.5A)
FOL  A 301 (-4.2A)
FOL  A 301 (-3.2A)
FOL  A 301 (-3.8A)
FOL  A 301 (-4.1A)
FOL  A 301 (-4.0A)
None
FOL  A 301 (-3.7A)
FOL  A 301 (-4.1A)
 0.00A 4lrhA-4lrhA:
40.3		 4lrhA-4lrhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lrh FOLATE RECEPTOR
ALPHA

(Homo sapiens) 		PF03024
(Folate_rec) 		5 TYR A  85
ARG A 103
ARG A 106
HIS A 135
TRP A 134
 FOL  A 301 (-4.1A)
FOL  A 301 (-3.2A)
FOL  A 301 (-3.8A)
FOL  A 301 (-4.1A)
None
 1.33A 4lrhA-4lrhA:
40.3		 4lrhA-4lrhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dex RHAMNOGALACTURONAN
ACETYLESTERASE

(Aspergillus
aculeatus) 		PF13472
(Lipase_GDSL_2) 		3 ASP A 192
TRP A 170
SER A   9
 None
 0.98A 4lrhA-1dexA:
0.0		 4lrhA-1dexA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eh5 PALMITOYL PROTEIN
THIOESTERASE 1

(Bos taurus) 		PF02089
(Palm_thioest) 		3 ASP A 233
TRP A 186
SER A 115
 None
None
PLM  A 430 (-1.2A)
 0.85A 4lrhA-1eh5A:
0.0		 4lrhA-1eh5A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ga8 GALACTOSYL
TRANSFERASE LGTC

(Neisseria
meningitidis) 		PF01501
(Glyco_transf_8) 		3 ASP A  37
TRP A 252
SER A  41
 None
 0.99A 4lrhA-1ga8A:
0.0		 4lrhA-1ga8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		3 ASP A  23
TRP A  60
SER A  97
 None
 0.98A 4lrhA-1i2lA:
0.0		 4lrhA-1i2lA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmu PROTEIN MU-1

(Reovirus sp.) 		PF05993
(Reovirus_M2) 		3 ASP B 553
TRP B 624
SER B 562
 None
 0.87A 4lrhA-1jmuB:
undetectable		 4lrhA-1jmuB:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.) 		PF07859
(Abhydrolase_3) 		3 ASP A  34
TRP A 209
SER A  97
 None
CAC  A 500 (-3.2A)
None
 0.88A 4lrhA-1lzkA:
0.0		 4lrhA-1lzkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1

(Sus scrofa) 		PF01909
(NTP_transf_2)
PF10421
(OAS1_C) 		3 ASP A  12
TRP A 326
SER A 250
 None
 0.84A 4lrhA-1px5A:
0.0		 4lrhA-1px5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qni NITROUS-OXIDE
REDUCTASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 3 ASP A 388
TRP A  24
SER A 384
 None
 1.04A 4lrhA-1qniA:
0.0		 4lrhA-1qniA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4y ACTIVIN RECEPTOR
TYPE IIB PRECURSOR
INHIBIN BETA A CHAIN

(Mus musculus;
Homo sapiens) 		PF01064
(Activin_recp)
PF00019
(TGF_beta) 		3 ASP A  59
TRP A  41
SER B  33
 None
 0.94A 4lrhA-1s4yA:
undetectable		 4lrhA-1s4yA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 ASP A 119
TRP A 385
SER A  89
 None
 1.06A 4lrhA-1u3dA:
undetectable		 4lrhA-1u3dA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		3 ASP A 136
TRP A 106
SER A 115
 None
 1.05A 4lrhA-1venA:
undetectable		 4lrhA-1venA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl7 ARABINANASE-TS

(Geobacillus
thermodenitrificans) 		PF04616
(Glyco_hydro_43) 		3 ASP A 147
TRP A  24
SER A 217
 None
 1.05A 4lrhA-1wl7A:
undetectable		 4lrhA-1wl7A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ASP A 201
TRP A 515
SER A 232
 None
SO4  A2001 (-4.7A)
None
 1.08A 4lrhA-1xkhA:
undetectable		 4lrhA-1xkhA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Mytilus edulis) 		PF00150
(Cellulase) 		3 ASP A 100
TRP A 172
SER A  86
 None
 1.01A 4lrhA-2c0hA:
undetectable		 4lrhA-2c0hA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER

(Bacillus
subtilis) 		PF07470
(Glyco_hydro_88) 		3 ASP A 350
TRP A 141
SER A 278
 None
 1.08A 4lrhA-2gh4A:
undetectable		 4lrhA-2gh4A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ASP A 345
TRP A  33
SER A 118
 None
PG4  A1354 (-3.7A)
None
 0.99A 4lrhA-2j6iA:
undetectable		 4lrhA-2j6iA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE

(Escherichia
coli) 		PF01204
(Trehalase) 		3 ASP A  59
TRP A 453
SER A 280
 None
None
VDM  A1548 (-3.5A)
 0.90A 4lrhA-2jf4A:
undetectable		 4lrhA-2jf4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lf2 UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF08327
(AHSA1) 		3 ASP A  96
TRP A  44
SER A  79
 None
 0.90A 4lrhA-2lf2A:
undetectable		 4lrhA-2lf2A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ls8 C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER D

(Homo sapiens) 		PF00059
(Lectin_C) 		3 ASP A  20
TRP A 111
SER A  27
 None
 1.07A 4lrhA-2ls8A:
undetectable		 4lrhA-2ls8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		3 ASP A 422
TRP A 491
SER A 323
 None
 1.01A 4lrhA-2o1xA:
undetectable		 4lrhA-2o1xA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qg7 ETHANOLAMINE KINASE
PV091845

(Plasmodium
vivax) 		PF01633
(Choline_kinase) 		3 ASP A 296
TRP A 378
SER A 300
 None
 1.07A 4lrhA-2qg7A:
undetectable		 4lrhA-2qg7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7r ESTERASE

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		3 ASP A 252
TRP A 215
SER A 188
 None
 0.91A 4lrhA-3d7rA:
undetectable		 4lrhA-3d7rA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbg PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 ASP A  43
TRP A 285
SER A  49
 None
 0.93A 4lrhA-3dbgA:
undetectable		 4lrhA-3dbgA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edm SHORT CHAIN
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		3 ASP A 147
TRP A 109
SER A 142
 None
 0.99A 4lrhA-3edmA:
undetectable		 4lrhA-3edmA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ASP A 379
TRP A  22
SER A 407
 None
None
TDP  A 611 ( 4.0A)
 1.03A 4lrhA-3eyaA:
undetectable		 4lrhA-3eyaA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyk HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ASP A  65
TRP A 236
SER A  73
 None
 0.91A 4lrhA-3eykA:
undetectable		 4lrhA-3eykA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmb DIMERIC PROTEIN OF
UNKNOWN FUNCTION AND
FERREDOXIN-LIKE FOLD

(Bacteroides
fragilis) 		PF07876
(Dabb) 		3 ASP A  96
TRP A  55
SER A  61
 None
 0.81A 4lrhA-3fmbA:
undetectable		 4lrhA-3fmbA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE

(Fusarium
graminearum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 193
TRP A 246
SER A  46
 None
 0.87A 4lrhA-3fxgA:
undetectable		 4lrhA-3fxgA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6l CHITINASE

(Clonostachys
rosea) 		PF00704
(Glyco_hydro_18) 		3 ASP A 172
TRP A 164
SER A 212
 None
 0.56A 4lrhA-3g6lA:
undetectable		 4lrhA-3g6lA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		3 ASP A 253
TRP A 278
SER A 337
 None
None
GOL  A 517 (-2.6A)
 1.05A 4lrhA-3ik2A:
undetectable		 4lrhA-3ik2A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im0 VAL-1

(Paramecium
bursaria
Chlorella virus
CVK2) 		no annotation 3 ASP A 216
TRP A 119
SER A 114
 None
 1.03A 4lrhA-3im0A:
undetectable		 4lrhA-3im0A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5

(Saccharomyces
cerevisiae) 		PF05916
(Sld5)
PF16922
(SLD5_C) 		3 ASP D 289
TRP D 224
SER D  66
 None
 1.02A 4lrhA-3jc7D:
undetectable		 4lrhA-3jc7D:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2i ACYL-COENZYME A
THIOESTERASE 4

(Homo sapiens) 		PF04775
(Bile_Hydr_Trans)
PF08840
(BAAT_C) 		3 ASP A 236
TRP A 384
SER A 253
 None
 1.04A 4lrhA-3k2iA:
undetectable		 4lrhA-3k2iA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg7 CURH

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		3 ASP A1199
TRP A1105
SER A1065
 None
 0.94A 4lrhA-3kg7A:
undetectable		 4lrhA-3kg7A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE

(Homo sapiens) 		PF05577
(Peptidase_S28) 		3 ASP B 153
TRP B 359
SER B 128
 None
 1.07A 4lrhA-3n2zB:
undetectable		 4lrhA-3n2zB:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqh GLYCOSYL HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		3 ASP A 402
TRP A 346
SER A 447
 None
 1.07A 4lrhA-3nqhA:
undetectable		 4lrhA-3nqhA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 ASP A  72
TRP A 278
SER A  14
 None
 0.98A 4lrhA-3nvaA:
undetectable		 4lrhA-3nvaA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pam TRANSMEMBRANE
PROTEIN

(Bartonella
henselae) 		PF00496
(SBP_bac_5) 		3 ASP A 535
TRP A 366
SER A 517
 None
 1.00A 4lrhA-3pamA:
undetectable		 4lrhA-3pamA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgv ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ASP A 164
TRP A 211
SER A 156
 CA  A 501 (-2.3A)
None
None
 0.67A 4lrhA-3qgvA:
undetectable		 4lrhA-3qgvA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0q PROBABLE PROTEIN
ARGININE
N-METHYLTRANSFERASE
4.2

(Arabidopsis
thaliana) 		no annotation 3 ASP C  76
TRP C 322
SER C  81
 SAH  C   1 ( 4.5A)
None
SAH  C   1 ( 4.4A)
 1.06A 4lrhA-3r0qC:
undetectable		 4lrhA-3r0qC:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		3 ASP A 141
TRP A  91
SER A 138
 None
 1.06A 4lrhA-3t6qA:
undetectable		 4lrhA-3t6qA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		3 ASP A 445
TRP A 423
SER A 137
 None
 1.08A 4lrhA-3tchA:
undetectable		 4lrhA-3tchA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttl POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		3 ASP A 180
TRP A  34
SER A 343
 None
 0.94A 4lrhA-3ttlA:
undetectable		 4lrhA-3ttlA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 ASP A 341
TRP A 107
SER A 595
 None
 0.90A 4lrhA-3w5nA:
undetectable		 4lrhA-3w5nA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 ASP B 921
TRP B1537
SER B 925
 None
 0.80A 4lrhA-3zefB:
undetectable		 4lrhA-3zefB:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 ASP B1700
TRP B1790
SER B1697
 None
 0.92A 4lrhA-3zefB:
undetectable		 4lrhA-3zefB:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP

(Salmonella
enterica) 		PF00814
(Peptidase_M22) 		3 ASP B 300
TRP B 329
SER B 136
 ZN  B1339 ( 2.5A)
None
AGS  B1342 (-2.9A)
 1.05A 4lrhA-3zeuB:
undetectable		 4lrhA-3zeuB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF02156
(Glyco_hydro_26)
PF16990
(CBM_35) 		3 ASP A 193
TRP A 320
SER A 198
 None
 0.94A 4lrhA-3zm8A:
undetectable		 4lrhA-3zm8A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bs9 TRUD

(uncultured
Prochloron sp.
06037A) 		PF02624
(YcaO) 		3 ASP A 603
TRP A 700
SER A 561
 None
 0.98A 4lrhA-4bs9A:
undetectable		 4lrhA-4bs9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		3 ASP A 296
TRP A 244
SER A 880
 None
 1.06A 4lrhA-4f7zA:
undetectable		 4lrhA-4f7zA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo7 METHIONINE
AMINOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF00557
(Peptidase_M24) 		3 ASP A 107
TRP A 220
SER A 109
 MN  A 302 ( 2.7A)
None
None
 0.92A 4lrhA-4fo7A:
undetectable		 4lrhA-4fo7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvm TLMII

(Streptoalloteichus
hindustanus) 		PF00668
(Condensation) 		3 ASP A 430
TRP A  23
SER A 417
 None
 1.00A 4lrhA-4hvmA:
undetectable		 4lrhA-4hvmA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		3 ASP A 328
TRP A  28
SER A 293
 None
 0.92A 4lrhA-4k0eA:
undetectable		 4lrhA-4k0eA:
10.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kmz FOLATE RECEPTOR BETA

(Homo sapiens) 		PF03024
(Folate_rec) 		3 ASP A  97
TRP A 156
SER A 190
 FOL  A 301 (-2.8A)
FOL  A 301 (-3.7A)
FOL  A 301 (-2.6A)
 0.25A 4lrhA-4kmzA:
35.2		 4lrhA-4kmzA:
77.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhs UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14606
(Lipase_GDSL_3)
PF14607
(GxDLY) 		3 ASP A 138
TRP A  90
SER A  83
 None
 1.06A 4lrhA-4lhsA:
undetectable		 4lrhA-4lhsA:
17.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lrh FOLATE RECEPTOR
ALPHA

(Homo sapiens) 		PF03024
(Folate_rec) 		3 ASP A  81
TRP A 140
SER A 174
 FOL  A 301 (-2.7A)
FOL  A 301 (-3.6A)
FOL  A 301 (-2.8A)
 0.00A 4lrhA-4lrhA:
40.3		 4lrhA-4lrhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		3 ASP A 377
TRP A 282
SER A 417
 None
 1.05A 4lrhA-4m7fA:
undetectable		 4lrhA-4m7fA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oic PROBABLE PROTEIN
PHOSPHATASE 2C 6

(Oryza sativa) 		PF00481
(PP2C) 		3 ASP B 164
TRP B 150
SER B 301
 None
 1.04A 4lrhA-4oicB:
undetectable		 4lrhA-4oicB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN

(Streptomyces
pristinaespiralis) 		no annotation 3 ASP A 223
TRP A 345
SER A  12
 None
 1.03A 4lrhA-4okmA:
undetectable		 4lrhA-4okmA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ony EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 5

(Brucella
melitensis) 		PF00496
(SBP_bac_5) 		3 ASP A 525
TRP A 356
SER A 507
 None
CL  A 601 (-4.2A)
None
 0.96A 4lrhA-4onyA:
undetectable		 4lrhA-4onyA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz2 ZMALDH

(Zea mays) 		PF00171
(Aldedh) 		3 ASP A 136
TRP A 344
SER A 122
 None
 0.95A 4lrhA-4pz2A:
undetectable		 4lrhA-4pz2A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2w URIDINE
PHOSPHORYLASE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		3 ASP A 114
TRP A 208
SER A 110
 None
 0.94A 4lrhA-4r2wA:
undetectable		 4lrhA-4r2wA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9j FICOLIN-2

(Homo sapiens) 		no annotation 3 ASP G 208
TRP G 117
SER G 248
 ACT  G 304 (-3.8A)
None
None
 1.05A 4lrhA-4r9jG:
undetectable		 4lrhA-4r9jG:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		3 ASP P  68
TRP P  74
SER P 117
 None
 0.99A 4lrhA-4s2tP:
undetectable		 4lrhA-4s2tP:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		3 ASP A 188
TRP A 750
SER A 679
 None
 0.77A 4lrhA-4u1rA:
undetectable		 4lrhA-4u1rA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 ASP A 425
TRP A 311
SER A 273
 None
None
EDO  A 717 ( 4.2A)
 1.08A 4lrhA-4wd1A:
undetectable		 4lrhA-4wd1A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yqy PUTATIVE
DEHYDROGENASE

(Sulfitobacter
sp. NAS-14.1) 		PF13561
(adh_short_C2) 		3 ASP A 146
TRP A 108
SER A 141
 None
 0.98A 4lrhA-4yqyA:
undetectable		 4lrhA-4yqyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgq CELL DIVISION CYCLE
PROTEIN 123

(Schizosaccharomyces
pombe) 		PF07065
(D123) 		3 ASP A 104
TRP A 166
SER A 128
 None
 1.05A 4lrhA-4zgqA:
undetectable		 4lrhA-4zgqA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi5 P91

(metagenome) 		PF01738
(DLH) 		3 ASP A 167
TRP A  90
SER A 200
 None
 0.85A 4lrhA-4zi5A:
undetectable		 4lrhA-4zi5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		3 ASP B 179
TRP B 638
SER B 653
 None
 0.79A 4lrhA-4zktB:
undetectable		 4lrhA-4zktB:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a99 POLYHEDRIN

(Operophtera
brumata
cypovirus 19) 		no annotation 3 ASP A  75
TRP A  63
SER A  45
 None
 0.97A 4lrhA-5a99A:
undetectable		 4lrhA-5a99A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 3 ASP A 108
TRP A 407
SER A 366
 None
 0.91A 4lrhA-5c2vA:
undetectable		 4lrhA-5c2vA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9g ISOCITRATE LYASE

(Magnaporthe
oryzae) 		PF00463
(ICL) 		3 ASP A 179
TRP A 463
SER A 110
 MG  A 603 ( 4.9A)
None
None
 1.05A 4lrhA-5e9gA:
undetectable		 4lrhA-5e9gA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9h ISOCITRATE LYASE

(Fusarium
graminearum) 		PF00463
(ICL) 		3 ASP A 179
TRP A 462
SER A 110
 None
 1.06A 4lrhA-5e9hA:
undetectable		 4lrhA-5e9hA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flw EXO-BETA-1,3-GALACTA
NASE

(Bifidobacterium
bifidum) 		PF04616
(Glyco_hydro_43) 		3 ASP A 167
TRP A 131
SER A 148
 None
 0.97A 4lrhA-5flwA:
undetectable		 4lrhA-5flwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1

(Thielavia
terrestris) 		PF05183
(RdRP) 		3 ASP A 141
TRP A  83
SER A 124
 None
 1.08A 4lrhA-5fswA:
undetectable		 4lrhA-5fswA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP1
VP2

(Deformed wing
virus;
Deformed wing
virus) 		PF08762
(CRPV_capsid)
PF00073
(Rhv) 		3 ASP B 143
TRP B 115
SER A 189
 None
 1.06A 4lrhA-5g52B:
undetectable		 4lrhA-5g52B:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		3 ASP A 279
TRP A 398
SER A 345
 None
 0.85A 4lrhA-5gsmA:
undetectable		 4lrhA-5gsmA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h12 DEEP VENT DNA
POLYMERASE

(Pyrococcus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 ASP A 422
TRP A 517
SER A 452
 None
 0.98A 4lrhA-5h12A:
undetectable		 4lrhA-5h12A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho9 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		3 ASP A 283
TRP A 250
SER A 353
 None
 0.97A 4lrhA-5ho9A:
undetectable		 4lrhA-5ho9A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C) 		3 ASP A 283
TRP A 250
SER A 353
 None
 1.07A 4lrhA-5hp6A:
undetectable		 4lrhA-5hp6A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6s ENDOGLUCANASE

(Talaromyces
verruculosus) 		PF00150
(Cellulase) 		3 ASP A 267
TRP A 281
SER A  12
 None
 1.04A 4lrhA-5i6sA:
undetectable		 4lrhA-5i6sA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j98 VP2
VP3

(Slow bee
paralysis
virus;
Slow bee
paralysis virus) 		PF00073
(Rhv)
PF00073
(Rhv) 		3 ASP C  52
TRP B  38
SER B  31
 None
 1.03A 4lrhA-5j98C:
undetectable		 4lrhA-5j98C:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp6 PUTATIVE
POLYSACCHARIDE
DEACETYLASE

(Bdellovibrio
bacteriovorus) 		PF01522
(Polysacc_deac_1) 		3 ASP A 336
TRP A 271
SER A 206
 None
 1.06A 4lrhA-5jp6A:
undetectable		 4lrhA-5jp6A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		3 ASP A 582
TRP A 511
SER A 638
 None
 0.82A 4lrhA-5jrlA:
undetectable		 4lrhA-5jrlA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Homo sapiens) 		PF01532
(Glyco_hydro_47) 		3 ASP A 463
TRP A 389
SER A 400
 MAN  A 708 (-2.5A)
NAG  A 706 (-3.7A)
None
 1.06A 4lrhA-5kijA:
undetectable		 4lrhA-5kijA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2

(Homo sapiens) 		PF00856
(SET)
PF01753
(zf-MYND) 		3 ASP A 188
TRP A 356
SER A 383
 None
 0.91A 4lrhA-5kjmA:
undetectable		 4lrhA-5kjmA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0p TRANSCRIPTION FACTOR
ETV6, TRANSCRIPTION
FACTOR ETV6,
TRANSCRIPTION FACTOR
ETV6, FERRIC UPTAKE
REGULATION PROTEIN
CHIMERA

(Klebsiella
pneumoniae;
Homo sapiens) 		PF01475
(FUR)
PF02198
(SAM_PNT) 		3 ASP A  75
TRP A  36
SER A  70
 None
 1.06A 4lrhA-5l0pA:
undetectable		 4lrhA-5l0pA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		3 ASP A 423
TRP A 392
SER A 599
 None
 1.01A 4lrhA-5l46A:
undetectable		 4lrhA-5l46A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		3 ASP X  44
TRP X 220
SER X 160
 NAP  X 401 (-3.7A)
None
NAP  X 401 (-2.8A)
 1.08A 4lrhA-5liyX:
undetectable		 4lrhA-5liyX:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 ASP A 711
TRP A 429
SER A 708
 None
 0.92A 4lrhA-5m2nA:
undetectable		 4lrhA-5m2nA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		3 ASP A 174
TRP A  73
SER A 138
 None
 1.06A 4lrhA-5m7rA:
undetectable		 4lrhA-5m7rA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH

(Staphylococcus
capitis) 		PF01566
(Nramp) 		3 ASP A 136
TRP A  53
SER A 378
 None
 1.07A 4lrhA-5m95A:
undetectable		 4lrhA-5m95A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 ASP A 582
TRP A 632
SER A 525
 None
 0.97A 4lrhA-5t98A:
undetectable		 4lrhA-5t98A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo sapiens) 		no annotation 3 ASP A1902
TRP A1945
SER A1570
 None
 1.04A 4lrhA-5wchA:
undetectable		 4lrhA-5wchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		3 ASP A 252
TRP A 260
SER A  16
 None
 0.98A 4lrhA-5wi5A:
undetectable		 4lrhA-5wi5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xl6 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ASP A  61
TRP A 231
SER A  69
 None
 1.00A 4lrhA-5xl6A:
undetectable		 4lrhA-5xl6A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c80 CYTOKININ OXIDASE
LUCKX1.1

(Linum
usitatissimum) 		no annotation 3 ASP A  61
TRP A 492
SER A  68
 None
 1.07A 4lrhA-6c80A:
undetectable		 4lrhA-6c80A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		3 ASP A2215
TRP B 254
SER B  33
 None
 0.71A 4lrhA-6emkA:
undetectable		 4lrhA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-) 		no annotation 3 ASP A 461
TRP A 130
SER A 242
 None
ADP  A2002 (-3.7A)
MG  A2001 (-3.2A)
 1.03A 4lrhA-6fsaA:
undetectable		 4lrhA-6fsaA:
undetectable