SIMILAR PATTERNS OF AMINO ACIDS FOR 4LNW_A_T3A502_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 12as | ASPARAGINESYNTHETASE (Escherichiacoli) |
PF03590(AsnA) | 4 | SER A 72ASP A 46GLN A 116ARG A 100 | ASN A 331 (-2.9A)ASN A 331 (-3.4A)ASN A 331 ( 3.5A)AMP A 332 (-2.9A) | 1.10A | 4lnwA-12asA:0.0 | 4lnwA-12asA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c4x | PROTEIN(2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE) (Rhodococcusjostii) |
PF12697(Abhydrolase_6) | 4 | GLU A 8GLN A 70VAL A 189ARG A 186 | None | 1.14A | 4lnwA-1c4xA:0.0 | 4lnwA-1c4xA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cvr | GINGIPAIN R (Porphyromonasgingivalis) |
PF01364(Peptidase_C25)PF03785(Peptidase_C25_C) | 4 | GLU A 132MET A 315VAL A 313THR A 314 | None | 1.11A | 4lnwA-1cvrA:0.0 | 4lnwA-1cvrA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f4h | BETA-GALACTOSIDASE (Escherichiacoli) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 4 | ASP A 224GLU A 243VAL A 444THR A 441 | None | 1.16A | 4lnwA-1f4hA:undetectable | 4lnwA-1f4hA:14.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gxs | P-(S)-HYDROXYMANDELONITRILE LYASE CHAINA (Sorghum bicolor) |
PF00450(Peptidase_S10) | 4 | ASP A 8GLU A 6GLN A 4THR A 30 | NoneNoneNoneNAG A1117 ( 3.8A) | 1.14A | 4lnwA-1gxsA:0.0 | 4lnwA-1gxsA:24.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i84 | SMOOTH MUSCLE MYOSINHEAVY CHAIN (Gallus gallus) |
PF00063(Myosin_head)PF00612(IQ)PF01576(Myosin_tail_1)PF02736(Myosin_N) | 4 | GLU S 529GLN S 522MET S 497THR S 496 | None | 1.07A | 4lnwA-1i84S:undetectable | 4lnwA-1i84S:12.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nav | HORMONE RECEPTORALPHA 1, THRA1 (Homo sapiens) |
PF00104(Hormone_recep) | 5 | GLU A 339GLN A 342MET A 369VAL A 371ARG A 375 | None | 1.32A | 4lnwA-1navA:37.5 | 4lnwA-1navA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nav | HORMONE RECEPTORALPHA 1, THRA1 (Homo sapiens) |
PF00104(Hormone_recep) | 7 | SER A 326ASP A 328GLU A 339GLN A 342VAL A 371THR A 372ARG A 375 | None | 1.22A | 4lnwA-1navA:37.5 | 4lnwA-1navA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nm3 | PROTEIN HI0572 (Haemophilusinfluenzae) |
PF00462(Glutaredoxin)PF08534(Redoxin) | 4 | SER A 196GLN A 169MET A 158ARG A 56 | None | 1.14A | 4lnwA-1nm3A:undetectable | 4lnwA-1nm3A:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ojl | TRANSCRIPTIONALREGULATORY PROTEINZRAR (Salmonellaenterica) |
PF00158(Sigma54_activat)PF02954(HTH_8) | 4 | SER A 311ASP A 170GLU A 308GLN A 314 | None | 1.09A | 4lnwA-1ojlA:0.0 | 4lnwA-1ojlA:22.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q4x | THYROID HORMONERECEPTOR BETA-1 (Homo sapiens) |
PF00104(Hormone_recep) | 5 | SER A 380ASP A 382GLN A 396VAL A 425THR A 426 | None | 1.03A | 4lnwA-1q4xA:36.7 | 4lnwA-1q4xA:81.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qdb | CYTOCHROME C NITRITEREDUCTASE (Sulfurospirillumdeleyianum) |
PF02335(Cytochrom_C552) | 4 | ASP A 267GLN A 281VAL A 237THR A 238 | CA A 520 ( 4.3A) CA A 520 ( 3.2A)HEM A 515 ( 4.7A)None | 1.15A | 4lnwA-1qdbA:undetectable | 4lnwA-1qdbA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhx | PROTEIN(CHLORAMPHENICOLPHOSPHOTRANSFERASE) (Streptomycesvenezuelae) |
PF07931(CPT) | 4 | ASP A 155GLU A 153GLN A 102VAL A 109 | None | 1.16A | 4lnwA-1qhxA:undetectable | 4lnwA-1qhxA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qpp | PAPD CHAPERONE (Escherichiacoli) |
PF00345(PapD_N)PF02753(PapD_C) | 4 | SER A 84GLU A 83VAL A 50THR A 71 | None | 1.03A | 4lnwA-1qppA:undetectable | 4lnwA-1qppA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s1d | APYRASE (Homo sapiens) |
PF06079(Apyrase) | 4 | SER A 98ASP A 112GLU A 214THR A 45 | GP2 A4001 (-4.8A)GP2 A4001 (-4.2A) CA A1001 (-4.0A)None | 0.80A | 4lnwA-1s1dA:undetectable | 4lnwA-1s1dA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vrq | SARCOSINE OXIDASEALPHA SUBUNIT (Corynebacteriumsp. U-96) |
PF01571(GCV_T)PF08669(GCV_T_C)PF12831(FAD_oxidored)PF13510(Fer2_4) | 4 | SER A 319ASP A 293GLU A 460VAL A 332 | None | 1.15A | 4lnwA-1vrqA:undetectable | 4lnwA-1vrqA:14.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xpg | 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINEMETHYLTRANSFERASE (Thermotogamaritima) |
PF01717(Meth_synt_2)PF08267(Meth_synt_1) | 4 | SER A 88GLU A 31MET A 73VAL A 72 | None | 1.10A | 4lnwA-1xpgA:undetectable | 4lnwA-1xpgA:15.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yq2 | BETA-GALACTOSIDASE (Arthrobactersp. C2-2) |
PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 4 | ASP A 392GLU A 147GLN A 202THR A 367 | None | 1.01A | 4lnwA-1yq2A:undetectable | 4lnwA-1yq2A:12.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3i | SIMILAR TORAD54-LIKE (Danio rerio) |
PF00176(SNF2_N)PF00271(Helicase_C) | 4 | SER X 214ASP X 238GLU X 270THR X 540 | SO4 X 737 (-4.3A)NoneSO4 X 737 (-4.1A)None | 0.87A | 4lnwA-1z3iX:undetectable | 4lnwA-1z3iX:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2anu | HYPOTHETICAL PROTEINTM0559 (Thermotogamaritima) |
no annotation | 4 | SER A 192ASP A 11GLU A 170THR A 16 | None | 1.07A | 4lnwA-2anuA:undetectable | 4lnwA-2anuA:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d7u | ADENYLOSUCCINATESYNTHETASE (Pyrococcushorikoshii) |
PF00709(Adenylsucc_synt) | 4 | ASP A 77GLU A 108VAL A 253ARG A 55 | None | 1.12A | 4lnwA-2d7uA:undetectable | 4lnwA-2d7uA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hdi | COLICIN I RECEPTOR (Escherichiacoli) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 4 | SER A 110ASP A 121GLU A 297THR A 99 | None | 1.13A | 4lnwA-2hdiA:undetectable | 4lnwA-2hdiA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j0a | BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASEMANIC FRINGE (Mus musculus) |
PF02434(Fringe) | 4 | ASP A 142GLU A 126VAL A 147THR A 273 | None | 1.07A | 4lnwA-2j0aA:undetectable | 4lnwA-2j0aA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jcj | N-ACETYLLACTOSAMINIDEALPHA-1,3-GALACTOSYLTRANSFERASE (Bos taurus) |
PF03414(Glyco_transf_6) | 4 | ASP A 348MET A 100VAL A 107THR A 99 | None | 1.15A | 4lnwA-2jcjA:undetectable | 4lnwA-2jcjA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2msr | PC4 ANDSFRS1-INTERACTINGPROTEIN (Homo sapiens) |
PF11467(LEDGF) | 5 | SER B 347GLU B 345MET B 387VAL B 385THR B 386 | None | 1.27A | 4lnwA-2msrB:undetectable | 4lnwA-2msrB:16.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nmp | CYSTATHIONINEGAMMA-LYASE (Homo sapiens) |
PF01053(Cys_Met_Meta_PP) | 4 | SER A 138ASP A 136GLN A 299THR A 163 | None | 1.16A | 4lnwA-2nmpA:undetectable | 4lnwA-2nmpA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2olw | RIBOSOMAL LARGESUBUNITPSEUDOURIDINESYNTHASE E (Escherichiacoli) |
PF00849(PseudoU_synth_2) | 4 | SER A 203ASP A 205VAL A 215ARG A 213 | NoneACY A1005 ( 4.7A)NoneNone | 1.14A | 4lnwA-2olwA:undetectable | 4lnwA-2olwA:25.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ph1 | NUCLEOTIDE-BINDINGPROTEIN (Archaeoglobusfulgidus) |
PF10609(ParA) | 4 | SER A 25GLU A 164VAL A 35THR A 34 | None | 0.96A | 4lnwA-2ph1A:undetectable | 4lnwA-2ph1A:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pts | ADENYLOSUCCINATELYASE (Escherichiacoli) |
PF00206(Lyase_1)PF08328(ASL_C) | 4 | SER A 331ASP A 336VAL A 342THR A 341 | None | 1.15A | 4lnwA-2ptsA:undetectable | 4lnwA-2ptsA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qga | ADENYLOSUCCINATELYASE (Plasmodiumvivax) |
PF00206(Lyase_1)PF08328(ASL_C) | 4 | SER B 329ASP B 334VAL B 340THR B 339 | NoneNoneNoneAMP B 908 (-4.6A) | 1.11A | 4lnwA-2qgaB:1.7 | 4lnwA-2qgaB:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wc7 | ALPHA AMYLASE,CATALYTIC REGION (Nostocpunctiforme) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 4 | SER A 337ASP A 334THR A 435ARG A 479 | None | 1.16A | 4lnwA-2wc7A:undetectable | 4lnwA-2wc7A:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wtk | SERINE/THREONINE-PROTEIN KINASE 11 (Homo sapiens) |
PF00069(Pkinase) | 5 | SER C 216ASP C 176GLN C 220VAL C 243THR C 244 | None | 1.39A | 4lnwA-2wtkC:undetectable | 4lnwA-2wtkC:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xkk | TOPOISOMERASE IV (Acinetobacterbaumannii) |
PF00521(DNA_topoisoIV)PF00986(DNA_gyraseB_C)PF01751(Toprim) | 4 | SER A1460GLU A1459VAL A1362THR A1363 | None | 0.88A | 4lnwA-2xkkA:undetectable | 4lnwA-2xkkA:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zsi | DELLA PROTEIN GAIPROBABLE GIBBERELLINRECEPTOR GID1L1 (Arabidopsisthaliana) |
PF07859(Abhydrolase_3)PF12041(DELLA) | 4 | SER A 25GLU B 54VAL A 319THR A 318 | NoneNoneGA4 A 345 (-4.2A)None | 1.10A | 4lnwA-2zsiA:undetectable | 4lnwA-2zsiA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a24 | ALPHA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF10566(Glyco_hydro_97)PF14508(GH97_N)PF14509(GH97_C) | 4 | SER A 27ASP A 29VAL A 275THR A 276 | None | 1.15A | 4lnwA-3a24A:undetectable | 4lnwA-3a24A:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bh2 | ACETOACETATEDECARBOXYLASE (Clostridiumacetobutylicum) |
PF06314(ADC) | 4 | SER A 126ASP A 127VAL A 130THR A 144 | None | 1.15A | 4lnwA-3bh2A:undetectable | 4lnwA-3bh2A:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bhg | ADENYLOSUCCINATELYASE (Legionellapneumophila) |
PF00206(Lyase_1)PF08328(ASL_C) | 4 | SER A 331ASP A 336VAL A 342THR A 341 | None | 1.12A | 4lnwA-3bhgA:undetectable | 4lnwA-3bhgA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bil | PROBABLE LACI-FAMILYTRANSCRIPTIONALREGULATOR (Corynebacteriumglutamicum) |
PF13407(Peripla_BP_4) | 4 | SER A 331MET A 251VAL A 255THR A 252 | None | 1.13A | 4lnwA-3bilA:undetectable | 4lnwA-3bilA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 4 | SER D 394GLU D 407GLN D 410THR D 440 | None | 1.07A | 4lnwA-3dzuD:22.3 | 4lnwA-3dzuD:24.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dzz | PUTATIVE PYRIDOXAL5'-PHOSPHATE-DEPENDENT C-S LYASE (Lactobacillusdelbrueckii) |
PF00155(Aminotran_1_2) | 4 | SER A 135ASP A 150VAL A 160THR A 157 | None | 0.97A | 4lnwA-3dzzA:undetectable | 4lnwA-3dzzA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e0f | PUTATIVEMETAL-DEPENDENTPHOSPHOESTERASE (Bifidobacteriumadolescentis) |
PF02811(PHP) | 4 | SER A 259ASP A 15GLU A 230THR A 20 | None | 0.97A | 4lnwA-3e0fA:undetectable | 4lnwA-3e0fA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ef1 | RNA POLYMERASE IISUBUNIT A C-TERMINALDOMAIN PHOSPHATASE (Schizosaccharomycespombe) |
PF03031(NIF)PF12738(PTCB-BRCT) | 4 | SER A 326GLU A 404VAL A 302ARG A 299 | None | 1.03A | 4lnwA-3ef1A:undetectable | 4lnwA-3ef1A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fhc | NUCLEAR PORE COMPLEXPROTEIN NUP214 (Homo sapiens) |
PF12894(ANAPC4_WD40) | 4 | SER A 101ASP A 103VAL A 179THR A 180 | None | 1.14A | 4lnwA-3fhcA:undetectable | 4lnwA-3fhcA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gwl | FAD-LINKEDSULFHYDRYL OXIDASE (African swinefever virus) |
PF04777(Evr1_Alr) | 4 | SER A 165ASP A 121GLU A 166GLN A 169 | None | 1.14A | 4lnwA-3gwlA:undetectable | 4lnwA-3gwlA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | SMALL NUCLEARRIBONUCLEOPROTEIN SMD1SMALL NUCLEARRIBONUCLEOPROTEIN SMD2 (Schizosaccharomycespombe) |
PF01423(LSM) | 4 | SER G 97ASP F 72VAL F 15THR F 14 | None | 1.00A | 4lnwA-3jb9G:undetectable | 4lnwA-3jb9G:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k70 | EXODEOXYRIBONUCLEASEV ALPHA CHAIN (Escherichiacoli) |
PF13538(UvrD_C_2)PF13604(AAA_30) | 4 | SER D 587ASP D 378VAL D 385THR D 384 | None | 1.11A | 4lnwA-3k70D:undetectable | 4lnwA-3k70D:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k7d | GLUTAMATE-AMMONIA-LIGASEADENYLYLTRANSFERASE (Escherichiacoli) |
PF03710(GlnE)PF08335(GlnD_UR_UTase) | 4 | GLN A 917VAL A 523THR A 524ARG A 527 | NoneSO4 A 5 ( 4.7A)NoneSO4 A 5 (-3.7A) | 0.83A | 4lnwA-3k7dA:undetectable | 4lnwA-3k7dA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ks5 | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE (Agrobacteriumfabrum) |
PF03009(GDPD) | 4 | ASP A 42MET A 85VAL A 46THR A 86 | None | 1.10A | 4lnwA-3ks5A:undetectable | 4lnwA-3ks5A:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ojc | PUTATIVEASPARTATE/GLUTAMATERACEMASE (Yersinia pestis) |
PF01177(Asp_Glu_race) | 4 | GLU A 50GLN A 53MET A 130THR A 129 | NoneNoneNone CA A 232 (-3.2A) | 1.13A | 4lnwA-3ojcA:undetectable | 4lnwA-3ojcA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3om5 | LEVANSUCRASE (Bacillusmegaterium) |
PF02435(Glyco_hydro_68) | 4 | SER A 422ASP A 95GLU A 352THR A 441 | NoneP6G A 485 ( 4.4A)P6G A 485 (-3.2A)None | 1.10A | 4lnwA-3om5A:undetectable | 4lnwA-3om5A:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q9t | CHOLINEDEHYDROGENASE ANDRELATEDFLAVOPROTEINS (Aspergillusoryzae) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | GLU A 271GLN A 267VAL A 245THR A 246 | ACT A 1 ( 2.8A)FAY A 600 (-3.2A)NoneNone | 1.04A | 4lnwA-3q9tA:undetectable | 4lnwA-3q9tA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3up3 | ACEDAF-12 (Ancylostomaceylanicum) |
PF00104(Hormone_recep) | 4 | MET A 492VAL A 494THR A 495ARG A 498 | NoneXCA A 100 ( 4.2A)XCA A 100 (-3.0A)None | 0.87A | 4lnwA-3up3A:20.2 | 4lnwA-3up3A:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a5a | NUCLEOSIDE-TRIPHOSPHATASE 1 (Toxoplasmagondii) |
PF01150(GDA1_CD39) | 4 | SER A 282GLU A 277GLN A 284ARG A 192 | ANP A 700 (-3.6A) MG A 701 (-4.7A)NoneNone | 1.14A | 4lnwA-4a5aA:undetectable | 4lnwA-4a5aA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4chg | ANTITOXIN VAPB15PROBABLERIBONUCLEASE VAPC15 (Mycobacteriumtuberculosis) |
PF01850(PIN)PF09957(VapB_antitoxin) | 4 | SER A 6GLU G 67VAL A 110THR A 128 | None MN A1133 ( 1.9A)NoneNone | 0.85A | 4lnwA-4chgA:undetectable | 4lnwA-4chgA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e8b | RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE E (Escherichiacoli) |
PF04452(Methyltrans_RNA) | 4 | SER A 76ASP A 241GLU A 75THR A 233 | None | 0.98A | 4lnwA-4e8bA:undetectable | 4lnwA-4e8bA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e8e | GLUTATHIONES-TRANSFERASE (Bombyx mori) |
PF13410(GST_C_2)PF13417(GST_N_3) | 4 | SER A 70GLN A 74VAL A 166THR A 167 | None | 0.89A | 4lnwA-4e8eA:undetectable | 4lnwA-4e8eA:24.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4efc | ADENYLOSUCCINATELYASE (Trypanosomabrucei) |
PF00206(Lyase_1)PF08328(ASL_C) | 4 | SER A 346ASP A 351VAL A 357THR A 356 | NoneNoneNoneAMP A 501 (-4.5A) | 1.10A | 4lnwA-4efcA:undetectable | 4lnwA-4efcA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4epu | ANGIOPOIETIN-1 (Homo sapiens) |
PF00147(Fibrinogen_C) | 4 | SER A 297ASP A 318MET A 491VAL A 326 | None | 1.16A | 4lnwA-4epuA:undetectable | 4lnwA-4epuA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdy | SIMILAR TOLIPOPROTEIN, NLP/P60FAMILY (Staphylococcusaureus) |
PF00877(NLPC_P60)PF13702(Lysozyme_like) | 4 | SER A 247GLN A 268VAL A 298THR A 296 | OCS A 246 ( 3.5A)NoneNoneNone | 1.12A | 4lnwA-4fdyA:undetectable | 4lnwA-4fdyA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fgv | CHROMOSOME REGIONMAINTENANCE 1 (CRM1)OR EXPORTIN 1 (XPO1) (Chaetomiumthermophilum) |
PF03810(IBN_N)PF08389(Xpo1)PF08767(CRM1_C) | 4 | GLU A 303GLN A 246THR A 208ARG A 211 | None | 1.13A | 4lnwA-4fgvA:undetectable | 4lnwA-4fgvA:13.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fl3 | TYROSINE-PROTEINKINASE SYK (Homo sapiens) |
PF00017(SH2)PF07714(Pkinase_Tyr) | 4 | SER A 350ASP A 428GLU A 349ARG A 359 | None | 0.99A | 4lnwA-4fl3A:undetectable | 4lnwA-4fl3A:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fxd | DNA POLYMERASE ALPHACATALYTIC SUBUNIT A (Saccharomycescerevisiae) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | ASP A 734GLN A 590VAL A 557THR A 545 | None | 1.05A | 4lnwA-4fxdA:undetectable | 4lnwA-4fxdA:15.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g54 | GENERAL SECRETIONPATHWAY PROTEIN (Vibriovulnificus) |
PF01471(PG_binding_1) | 4 | GLN A 539VAL A 428THR A 437ARG A 426 | None | 1.04A | 4lnwA-4g54A:undetectable | 4lnwA-4g54A:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g7e | UREASE (Cajanus cajan) |
PF00449(Urease_alpha)PF00547(Urease_gamma)PF00699(Urease_beta)PF01979(Amidohydro_1) | 4 | SER B 370ASP B 356VAL B 320THR B 314 | None | 1.09A | 4lnwA-4g7eB:undetectable | 4lnwA-4g7eB:16.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gis | ENOLASE (Vibrio harveyi) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ASP A 179GLN A 217VAL A 186THR A 185 | None | 1.02A | 4lnwA-4gisA:undetectable | 4lnwA-4gisA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hkt | INOSITOL2-DEHYDROGENASE (Sinorhizobiummeliloti) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | SER A 150ASP A 175GLN A 237MET A 129 | NoneNoneNoneEDO A 407 (-4.7A) | 1.09A | 4lnwA-4hktA:undetectable | 4lnwA-4hktA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwu | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Mus musculus) |
PF13927(Ig_3) | 4 | ASP A 66VAL A 113THR A 112ARG A 111 | None | 0.98A | 4lnwA-4hwuA:undetectable | 4lnwA-4hwuA:16.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hzu | ENERGY-COUPLINGFACTOR TRANSPORTERATP-BINDING PROTEINECFA 1ENERGY-COUPLINGFACTOR TRANSPORTERATP-BINDING PROTEINECFA 2 (Lactobacillusbrevis) |
PF00005(ABC_tran) | 4 | ASP A 240GLU B 207GLN B 205THR A 168 | None | 1.04A | 4lnwA-4hzuA:undetectable | 4lnwA-4hzuA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jlv | C-TERMINAL FRAGMENTOF MEMBRANE PROTEINCAPA1, PUTATIVEUNCHARACTERIZEDPROTEIN CAPB1 (Staphylococcusaureus) |
PF13614(AAA_31) | 4 | SER A1048GLU A1049VAL A1058THR A1057 | ADP A1301 ( 4.5A)NoneNoneADP A1301 (-3.8A) | 0.78A | 4lnwA-4jlvA:undetectable | 4lnwA-4jlvA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ktp | GLYCOSIDE HYDROLASEFAMILY 65 CENTRALCATALYTIC ([Bacillus]selenitireducens) |
PF03632(Glyco_hydro_65m)PF03633(Glyco_hydro_65C)PF03636(Glyco_hydro_65N) | 4 | GLU A 640VAL A 724THR A 725ARG A 761 | None | 1.13A | 4lnwA-4ktpA:undetectable | 4lnwA-4ktpA:17.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ldq | METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE (Homo sapiens) |
PF01008(IF-2B) | 4 | ASP A 248GLU A 298MET A 96VAL A 94 | None | 1.03A | 4lnwA-4ldqA:undetectable | 4lnwA-4ldqA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mx2 | ADENYLOSUCCINATELYASE (Leishmaniadonovani) |
PF00206(Lyase_1)PF08328(ASL_C) | 4 | SER A 357ASP A 362VAL A 368THR A 367 | NoneNoneNoneAMP A 501 (-4.4A) | 1.12A | 4lnwA-4mx2A:undetectable | 4lnwA-4mx2A:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o27 | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) |
PF00069(Pkinase) | 4 | ASP B 66GLU B 178VAL B 73THR B 72 | None | 1.14A | 4lnwA-4o27B:undetectable | 4lnwA-4o27B:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oye | 425AA LONGHYPOTHETICAL PROTONGLUTAMATE SYMPORTPROTEIN (Pyrococcushorikoshii) |
PF00375(SDF) | 4 | GLU A 291MET A 399VAL A 402THR A 403 | None | 1.15A | 4lnwA-4oyeA:undetectable | 4lnwA-4oyeA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4psd | CARBOHYDRATEESTERASE FAMILY 5 (Trichodermareesei) |
PF01083(Cutinase) | 4 | SER A 167ASP A 193VAL A 188THR A 208 | None | 1.13A | 4lnwA-4psdA:undetectable | 4lnwA-4psdA:25.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qfu | GLYCOSIDE HYDROLASEFAMILY 5 (Bacteroidesvulgatus) |
PF12904(Collagen_bind_2)PF13204(DUF4038) | 4 | SER A 430ASP A 433GLN A 461THR A 478 | None | 1.01A | 4lnwA-4qfuA:undetectable | 4lnwA-4qfuA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r0c | ABGT PUTATIVETRANSPORTER FAMILY (Alcanivoraxborkumensis) |
PF03806(ABG_transport) | 4 | ASP A 134MET A 327VAL A 329THR A 330 | NoneLMT A 806 ( 4.4A)NoneNone | 1.05A | 4lnwA-4r0cA:undetectable | 4lnwA-4r0cA:19.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4s15 | NUCLEAR RECEPTORROR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 4 | GLU A 443GLN A 446VAL A 474ARG A 478 | None | 0.92A | 4lnwA-4s15A:26.7 | 4lnwA-4s15A:32.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wj3 | ASPARTYL/GLUTAMYL-TRNA(ASN/GLN)AMIDOTRANSFERASESUBUNIT BGLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A (Pseudomonasaeruginosa) |
PF01425(Amidase)PF02637(GatB_Yqey)PF02934(GatB_N) | 4 | SER A 197ASP A 232MET B 44THR B 47 | None | 1.10A | 4lnwA-4wj3A:undetectable | 4lnwA-4wj3A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zht | BIFUNCTIONALUDP-N-ACETYLGLUCOSAMINE2-EPIMERASE/N-ACETYLMANNOSAMINE KINASE (Homo sapiens) |
PF02350(Epimerase_2) | 4 | SER A 139ASP A 144VAL A 222THR A 224 | None | 1.13A | 4lnwA-4zhtA:undetectable | 4lnwA-4zhtA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zuz | SIDC (Legionellapneumophila) |
no annotation | 4 | SER A 154GLU A 156THR A 476ARG A 477 | None | 1.10A | 4lnwA-4zuzA:undetectable | 4lnwA-4zuzA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cdf | ATP SYNTHASE SUBUNITBETA (Paracoccusdenitrificans) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N) | 4 | ASP E 252GLN E 217MET E 226VAL E 228 | None | 0.99A | 4lnwA-5cdfE:undetectable | 4lnwA-5cdfE:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5doo | PROTEIN LYSINEMETHYLTRANSFERASE 2 (Rickettsiatyphi) |
PF10119(MethyTransf_Reg)PF13847(Methyltransf_31) | 4 | SER A 122GLN A 129VAL A 148THR A 294 | None | 1.09A | 4lnwA-5dooA:undetectable | 4lnwA-5dooA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dz6 | POLYKETIDEBIOSYNTHESIS MALONYLCOA-ACYL CARRIERPROTEIN TRANSACYLASEPKSC (Bacillussubtilis) |
PF00698(Acyl_transf_1) | 4 | GLN A 134MET A 182VAL A 180THR A 181 | None | 1.09A | 4lnwA-5dz6A:undetectable | 4lnwA-5dz6A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f5o | NUCLEOPROTEIN (Marburgmarburgvirus) |
PF05505(Ebola_NP) | 4 | SER A 217GLN A 220VAL A 160THR A 159 | None | 0.90A | 4lnwA-5f5oA:undetectable | 4lnwA-5f5oA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gjw | VOLTAGE-DEPENDENTCALCIUM CHANNELSUBUNITALPHA-2/DELTA-1 (Oryctolaguscuniculus) |
PF00092(VWA)PF08399(VWA_N)PF08473(VGCC_alpha2) | 4 | SER F 884MET F 851VAL F1021ARG F1004 | None | 1.15A | 4lnwA-5gjwF:undetectable | 4lnwA-5gjwF:13.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hp5 | PROTEIN-ARGININEDEIMINASE TYPE-1 (Homo sapiens) |
PF03068(PAD)PF08526(PAD_N)PF08527(PAD_M) | 4 | ASP A 258GLN A 455VAL A 394THR A 395 | None | 1.16A | 4lnwA-5hp5A:undetectable | 4lnwA-5hp5A:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6v | TYROSINE-PROTEINPHOSPHATASENON-RECEPTOR TYPE 11 (Homo sapiens) |
PF00017(SH2)PF00102(Y_phosphatase) | 4 | SER A 460ASP A 61GLU A 361THR A 468 | None | 0.89A | 4lnwA-5i6vA:undetectable | 4lnwA-5i6vA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l8s | AMINO ACYL PEPTIDASE (Sporosarcinapsychrophila) |
PF00326(Peptidase_S9) | 4 | SER A 247GLN A 249VAL A 202THR A 178 | None | 1.15A | 4lnwA-5l8sA:undetectable | 4lnwA-5l8sA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n6m | APOLIPOPROTEINN-ACYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00795(CN_hydrolase) | 4 | SER A 405ASP A 407MET A 425ARG A 436 | None | 0.80A | 4lnwA-5n6mA:undetectable | 4lnwA-5n6mA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n94 | CG9323, ISOFORM A (Drosophilamelanogaster) |
no annotation | 4 | SER A 576ASP A 637GLU A 575VAL A 285 | None U C 7 ( 4.8A)NoneNone | 1.13A | 4lnwA-5n94A:undetectable | 4lnwA-5n94A:15.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nd1 | CAPSID PROTEIN (Rosellinianecatrixquadrivirus 1) |
no annotation | 4 | SER A 729GLU A 688VAL A 558THR A 557 | None | 0.92A | 4lnwA-5nd1A:undetectable | 4lnwA-5nd1A:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t1p | ABC TRANSPORTER,PERIPLASMICSUBSTRATE-BINDINGPROTEIN (Campylobacterjejuni) |
PF13343(SBP_bac_6) | 4 | SER A 38ASP A 65GLU A 73THR A 51 | NoneNoneGPE A 402 ( 4.6A)None | 1.10A | 4lnwA-5t1pA:undetectable | 4lnwA-5t1pA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t4y | SUSC HOMOLOG (Bacteroidesthetaiotaomicron) |
no annotation | 4 | SER D 556ASP D 578GLU D 510THR D 574 | None | 1.16A | 4lnwA-5t4yD:undetectable | 4lnwA-5t4yD:13.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wgx | FLAVIN-DEPENDENTHALOGENASE (Malbrancheaaurantiaca) |
PF04820(Trp_halogenase) | 4 | ASP A 292MET A 281VAL A 284THR A 285 | None | 0.96A | 4lnwA-5wgxA:undetectable | 4lnwA-5wgxA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xhq | APOLIPOPROTEINN-ACYLTRANSFERASE (Escherichiacoli) |
PF00795(CN_hydrolase) | 4 | SER A 411ASP A 413MET A 431ARG A 442 | None | 1.16A | 4lnwA-5xhqA:undetectable | 4lnwA-5xhqA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xsq | NUCLEOPROTEIN (Marburgmarburgvirus) |
PF05505(Ebola_NP) | 4 | SER A 201GLN A 204VAL A 144THR A 143 | None | 0.83A | 4lnwA-5xsqA:undetectable | 4lnwA-5xsqA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zov | - (-) |
no annotation | 4 | GLU A 391GLN A 337VAL A 239THR A 236 | None | 0.88A | 4lnwA-5zovA:undetectable | 4lnwA-5zovA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zvs | PUTATIVE COREPROTEIN NTPASE/VP5 (Aquareovirus C) |
no annotation | 4 | SER 4 475ASP 4 482VAL 4 488THR 4 487 | None | 0.91A | 4lnwA-5zvs4:undetectable | 4lnwA-5zvs4:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eu9 | RETINOIC ACIDRECEPTOR (Platynereisdumerilii) |
no annotation | 4 | SER A 464ASP A 466GLN A 480THR A 510 | None | 0.99A | 4lnwA-6eu9A:28.4 | 4lnwA-6eu9A:29.25 |