SIMILAR PATTERNS OF AMINO ACIDS FOR 4LNW_A_T3A502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
12as ASPARAGINE
SYNTHETASE


(Escherichia
coli)
PF03590
(AsnA)
4 SER A  72
ASP A  46
GLN A 116
ARG A 100
ASN  A 331 (-2.9A)
ASN  A 331 (-3.4A)
ASN  A 331 ( 3.5A)
AMP  A 332 (-2.9A)
1.10A 4lnwA-12asA:
0.0
4lnwA-12asA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)


(Rhodococcus
jostii)
PF12697
(Abhydrolase_6)
4 GLU A   8
GLN A  70
VAL A 189
ARG A 186
None
1.14A 4lnwA-1c4xA:
0.0
4lnwA-1c4xA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis)
PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C)
4 GLU A 132
MET A 315
VAL A 313
THR A 314
None
1.11A 4lnwA-1cvrA:
0.0
4lnwA-1cvrA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981)
4 ASP A 224
GLU A 243
VAL A 444
THR A 441
None
1.16A 4lnwA-1f4hA:
undetectable
4lnwA-1f4hA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A


(Sorghum bicolor)
PF00450
(Peptidase_S10)
4 ASP A   8
GLU A   6
GLN A   4
THR A  30
None
None
None
NAG  A1117 ( 3.8A)
1.14A 4lnwA-1gxsA:
0.0
4lnwA-1gxsA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN


(Gallus gallus)
PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N)
4 GLU S 529
GLN S 522
MET S 497
THR S 496
None
1.07A 4lnwA-1i84S:
undetectable
4lnwA-1i84S:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1


(Homo sapiens)
PF00104
(Hormone_recep)
5 GLU A 339
GLN A 342
MET A 369
VAL A 371
ARG A 375
None
1.32A 4lnwA-1navA:
37.5
4lnwA-1navA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1


(Homo sapiens)
PF00104
(Hormone_recep)
7 SER A 326
ASP A 328
GLU A 339
GLN A 342
VAL A 371
THR A 372
ARG A 375
None
1.22A 4lnwA-1navA:
37.5
4lnwA-1navA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nm3 PROTEIN HI0572

(Haemophilus
influenzae)
PF00462
(Glutaredoxin)
PF08534
(Redoxin)
4 SER A 196
GLN A 169
MET A 158
ARG A  56
None
1.14A 4lnwA-1nm3A:
undetectable
4lnwA-1nm3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ojl TRANSCRIPTIONAL
REGULATORY PROTEIN
ZRAR


(Salmonella
enterica)
PF00158
(Sigma54_activat)
PF02954
(HTH_8)
4 SER A 311
ASP A 170
GLU A 308
GLN A 314
None
1.09A 4lnwA-1ojlA:
0.0
4lnwA-1ojlA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1


(Homo sapiens)
PF00104
(Hormone_recep)
5 SER A 380
ASP A 382
GLN A 396
VAL A 425
THR A 426
None
1.03A 4lnwA-1q4xA:
36.7
4lnwA-1q4xA:
81.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdb CYTOCHROME C NITRITE
REDUCTASE


(Sulfurospirillum
deleyianum)
PF02335
(Cytochrom_C552)
4 ASP A 267
GLN A 281
VAL A 237
THR A 238
CA  A 520 ( 4.3A)
CA  A 520 ( 3.2A)
HEM  A 515 ( 4.7A)
None
1.15A 4lnwA-1qdbA:
undetectable
4lnwA-1qdbA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)


(Streptomyces
venezuelae)
PF07931
(CPT)
4 ASP A 155
GLU A 153
GLN A 102
VAL A 109
None
1.16A 4lnwA-1qhxA:
undetectable
4lnwA-1qhxA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpp PAPD CHAPERONE

(Escherichia
coli)
PF00345
(PapD_N)
PF02753
(PapD_C)
4 SER A  84
GLU A  83
VAL A  50
THR A  71
None
1.03A 4lnwA-1qppA:
undetectable
4lnwA-1qppA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1d APYRASE

(Homo sapiens)
PF06079
(Apyrase)
4 SER A  98
ASP A 112
GLU A 214
THR A  45
GP2  A4001 (-4.8A)
GP2  A4001 (-4.2A)
CA  A1001 (-4.0A)
None
0.80A 4lnwA-1s1dA:
undetectable
4lnwA-1s1dA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT


(Corynebacterium
sp. U-96)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4)
4 SER A 319
ASP A 293
GLU A 460
VAL A 332
None
1.15A 4lnwA-1vrqA:
undetectable
4lnwA-1vrqA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE


(Thermotoga
maritima)
PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1)
4 SER A  88
GLU A  31
MET A  73
VAL A  72
None
1.10A 4lnwA-1xpgA:
undetectable
4lnwA-1xpgA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981)
4 ASP A 392
GLU A 147
GLN A 202
THR A 367
None
1.01A 4lnwA-1yq2A:
undetectable
4lnwA-1yq2A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE


(Danio rerio)
PF00176
(SNF2_N)
PF00271
(Helicase_C)
4 SER X 214
ASP X 238
GLU X 270
THR X 540
SO4  X 737 (-4.3A)
None
SO4  X 737 (-4.1A)
None
0.87A 4lnwA-1z3iX:
undetectable
4lnwA-1z3iX:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anu HYPOTHETICAL PROTEIN
TM0559


(Thermotoga
maritima)
no annotation 4 SER A 192
ASP A  11
GLU A 170
THR A  16
None
1.07A 4lnwA-2anuA:
undetectable
4lnwA-2anuA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7u ADENYLOSUCCINATE
SYNTHETASE


(Pyrococcus
horikoshii)
PF00709
(Adenylsucc_synt)
4 ASP A  77
GLU A 108
VAL A 253
ARG A  55
None
1.12A 4lnwA-2d7uA:
undetectable
4lnwA-2d7uA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR

(Escherichia
coli)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
4 SER A 110
ASP A 121
GLU A 297
THR A  99
None
1.13A 4lnwA-2hdiA:
undetectable
4lnwA-2hdiA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE


(Mus musculus)
PF02434
(Fringe)
4 ASP A 142
GLU A 126
VAL A 147
THR A 273
None
1.07A 4lnwA-2j0aA:
undetectable
4lnwA-2j0aA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE


(Bos taurus)
PF03414
(Glyco_transf_6)
4 ASP A 348
MET A 100
VAL A 107
THR A  99
None
1.15A 4lnwA-2jcjA:
undetectable
4lnwA-2jcjA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2msr PC4 AND
SFRS1-INTERACTING
PROTEIN


(Homo sapiens)
PF11467
(LEDGF)
5 SER B 347
GLU B 345
MET B 387
VAL B 385
THR B 386
None
1.27A 4lnwA-2msrB:
undetectable
4lnwA-2msrB:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE


(Homo sapiens)
PF01053
(Cys_Met_Meta_PP)
4 SER A 138
ASP A 136
GLN A 299
THR A 163
None
1.16A 4lnwA-2nmpA:
undetectable
4lnwA-2nmpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2olw RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E


(Escherichia
coli)
PF00849
(PseudoU_synth_2)
4 SER A 203
ASP A 205
VAL A 215
ARG A 213
None
ACY  A1005 ( 4.7A)
None
None
1.14A 4lnwA-2olwA:
undetectable
4lnwA-2olwA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph1 NUCLEOTIDE-BINDING
PROTEIN


(Archaeoglobus
fulgidus)
PF10609
(ParA)
4 SER A  25
GLU A 164
VAL A  35
THR A  34
None
0.96A 4lnwA-2ph1A:
undetectable
4lnwA-2ph1A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pts ADENYLOSUCCINATE
LYASE


(Escherichia
coli)
PF00206
(Lyase_1)
PF08328
(ASL_C)
4 SER A 331
ASP A 336
VAL A 342
THR A 341
None
1.15A 4lnwA-2ptsA:
undetectable
4lnwA-2ptsA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qga ADENYLOSUCCINATE
LYASE


(Plasmodium
vivax)
PF00206
(Lyase_1)
PF08328
(ASL_C)
4 SER B 329
ASP B 334
VAL B 340
THR B 339
None
None
None
AMP  B 908 (-4.6A)
1.11A 4lnwA-2qgaB:
1.7
4lnwA-2qgaB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc7 ALPHA AMYLASE,
CATALYTIC REGION


(Nostoc
punctiforme)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
4 SER A 337
ASP A 334
THR A 435
ARG A 479
None
1.16A 4lnwA-2wc7A:
undetectable
4lnwA-2wc7A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11


(Homo sapiens)
PF00069
(Pkinase)
5 SER C 216
ASP C 176
GLN C 220
VAL C 243
THR C 244
None
1.39A 4lnwA-2wtkC:
undetectable
4lnwA-2wtkC:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
4 SER A1460
GLU A1459
VAL A1362
THR A1363
None
0.88A 4lnwA-2xkkA:
undetectable
4lnwA-2xkkA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsi DELLA PROTEIN GAI
PROBABLE GIBBERELLIN
RECEPTOR GID1L1


(Arabidopsis
thaliana)
PF07859
(Abhydrolase_3)
PF12041
(DELLA)
4 SER A  25
GLU B  54
VAL A 319
THR A 318
None
None
GA4  A 345 (-4.2A)
None
1.10A 4lnwA-2zsiA:
undetectable
4lnwA-2zsiA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron)
PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C)
4 SER A  27
ASP A  29
VAL A 275
THR A 276
None
1.15A 4lnwA-3a24A:
undetectable
4lnwA-3a24A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh2 ACETOACETATE
DECARBOXYLASE


(Clostridium
acetobutylicum)
PF06314
(ADC)
4 SER A 126
ASP A 127
VAL A 130
THR A 144
None
1.15A 4lnwA-3bh2A:
undetectable
4lnwA-3bh2A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhg ADENYLOSUCCINATE
LYASE


(Legionella
pneumophila)
PF00206
(Lyase_1)
PF08328
(ASL_C)
4 SER A 331
ASP A 336
VAL A 342
THR A 341
None
1.12A 4lnwA-3bhgA:
undetectable
4lnwA-3bhgA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bil PROBABLE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR


(Corynebacterium
glutamicum)
PF13407
(Peripla_BP_4)
4 SER A 331
MET A 251
VAL A 255
THR A 252
None
1.13A 4lnwA-3bilA:
undetectable
4lnwA-3bilA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
4 SER D 394
GLU D 407
GLN D 410
THR D 440
None
1.07A 4lnwA-3dzuD:
22.3
4lnwA-3dzuD:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE


(Lactobacillus
delbrueckii)
PF00155
(Aminotran_1_2)
4 SER A 135
ASP A 150
VAL A 160
THR A 157
None
0.97A 4lnwA-3dzzA:
undetectable
4lnwA-3dzzA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0f PUTATIVE
METAL-DEPENDENT
PHOSPHOESTERASE


(Bifidobacterium
adolescentis)
PF02811
(PHP)
4 SER A 259
ASP A  15
GLU A 230
THR A  20
None
0.97A 4lnwA-3e0fA:
undetectable
4lnwA-3e0fA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE


(Schizosaccharomyces
pombe)
PF03031
(NIF)
PF12738
(PTCB-BRCT)
4 SER A 326
GLU A 404
VAL A 302
ARG A 299
None
1.03A 4lnwA-3ef1A:
undetectable
4lnwA-3ef1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214


(Homo sapiens)
PF12894
(ANAPC4_WD40)
4 SER A 101
ASP A 103
VAL A 179
THR A 180
None
1.14A 4lnwA-3fhcA:
undetectable
4lnwA-3fhcA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwl FAD-LINKED
SULFHYDRYL OXIDASE


(African swine
fever virus)
PF04777
(Evr1_Alr)
4 SER A 165
ASP A 121
GLU A 166
GLN A 169
None
1.14A 4lnwA-3gwlA:
undetectable
4lnwA-3gwlA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2


(Schizosaccharomyces
pombe)
PF01423
(LSM)
4 SER G  97
ASP F  72
VAL F  15
THR F  14
None
1.00A 4lnwA-3jb9G:
undetectable
4lnwA-3jb9G:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN


(Escherichia
coli)
PF13538
(UvrD_C_2)
PF13604
(AAA_30)
4 SER D 587
ASP D 378
VAL D 385
THR D 384
None
1.11A 4lnwA-3k70D:
undetectable
4lnwA-3k70D:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7d GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE


(Escherichia
coli)
PF03710
(GlnE)
PF08335
(GlnD_UR_UTase)
4 GLN A 917
VAL A 523
THR A 524
ARG A 527
None
SO4  A   5 ( 4.7A)
None
SO4  A   5 (-3.7A)
0.83A 4lnwA-3k7dA:
undetectable
4lnwA-3k7dA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks5 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Agrobacterium
fabrum)
PF03009
(GDPD)
4 ASP A  42
MET A  85
VAL A  46
THR A  86
None
1.10A 4lnwA-3ks5A:
undetectable
4lnwA-3ks5A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojc PUTATIVE
ASPARTATE/GLUTAMATE
RACEMASE


(Yersinia pestis)
PF01177
(Asp_Glu_race)
4 GLU A  50
GLN A  53
MET A 130
THR A 129
None
None
None
CA  A 232 (-3.2A)
1.13A 4lnwA-3ojcA:
undetectable
4lnwA-3ojcA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium)
PF02435
(Glyco_hydro_68)
4 SER A 422
ASP A  95
GLU A 352
THR A 441
None
P6G  A 485 ( 4.4A)
P6G  A 485 (-3.2A)
None
1.10A 4lnwA-3om5A:
undetectable
4lnwA-3om5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS


(Aspergillus
oryzae)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 GLU A 271
GLN A 267
VAL A 245
THR A 246
ACT  A   1 ( 2.8A)
FAY  A 600 (-3.2A)
None
None
1.04A 4lnwA-3q9tA:
undetectable
4lnwA-3q9tA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up3 ACEDAF-12

(Ancylostoma
ceylanicum)
PF00104
(Hormone_recep)
4 MET A 492
VAL A 494
THR A 495
ARG A 498
None
XCA  A 100 ( 4.2A)
XCA  A 100 (-3.0A)
None
0.87A 4lnwA-3up3A:
20.2
4lnwA-3up3A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5a NUCLEOSIDE-TRIPHOSPH
ATASE 1


(Toxoplasma
gondii)
PF01150
(GDA1_CD39)
4 SER A 282
GLU A 277
GLN A 284
ARG A 192
ANP  A 700 (-3.6A)
MG  A 701 (-4.7A)
None
None
1.14A 4lnwA-4a5aA:
undetectable
4lnwA-4a5aA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chg ANTITOXIN VAPB15
PROBABLE
RIBONUCLEASE VAPC15


(Mycobacterium
tuberculosis)
PF01850
(PIN)
PF09957
(VapB_antitoxin)
4 SER A   6
GLU G  67
VAL A 110
THR A 128
None
MN  A1133 ( 1.9A)
None
None
0.85A 4lnwA-4chgA:
undetectable
4lnwA-4chgA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E


(Escherichia
coli)
PF04452
(Methyltrans_RNA)
4 SER A  76
ASP A 241
GLU A  75
THR A 233
None
0.98A 4lnwA-4e8bA:
undetectable
4lnwA-4e8bA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8e GLUTATHIONE
S-TRANSFERASE


(Bombyx mori)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
4 SER A  70
GLN A  74
VAL A 166
THR A 167
None
0.89A 4lnwA-4e8eA:
undetectable
4lnwA-4e8eA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE


(Trypanosoma
brucei)
PF00206
(Lyase_1)
PF08328
(ASL_C)
4 SER A 346
ASP A 351
VAL A 357
THR A 356
None
None
None
AMP  A 501 (-4.5A)
1.10A 4lnwA-4efcA:
undetectable
4lnwA-4efcA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epu ANGIOPOIETIN-1

(Homo sapiens)
PF00147
(Fibrinogen_C)
4 SER A 297
ASP A 318
MET A 491
VAL A 326
None
1.16A 4lnwA-4epuA:
undetectable
4lnwA-4epuA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY


(Staphylococcus
aureus)
PF00877
(NLPC_P60)
PF13702
(Lysozyme_like)
4 SER A 247
GLN A 268
VAL A 298
THR A 296
OCS  A 246 ( 3.5A)
None
None
None
1.12A 4lnwA-4fdyA:
undetectable
4lnwA-4fdyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)


(Chaetomium
thermophilum)
PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C)
4 GLU A 303
GLN A 246
THR A 208
ARG A 211
None
1.13A 4lnwA-4fgvA:
undetectable
4lnwA-4fgvA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
4 SER A 350
ASP A 428
GLU A 349
ARG A 359
None
0.99A 4lnwA-4fl3A:
undetectable
4lnwA-4fl3A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A


(Saccharomyces
cerevisiae)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
4 ASP A 734
GLN A 590
VAL A 557
THR A 545
None
1.05A 4lnwA-4fxdA:
undetectable
4lnwA-4fxdA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g54 GENERAL SECRETION
PATHWAY PROTEIN


(Vibrio
vulnificus)
PF01471
(PG_binding_1)
4 GLN A 539
VAL A 428
THR A 437
ARG A 426
None
1.04A 4lnwA-4g54A:
undetectable
4lnwA-4g54A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan)
PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1)
4 SER B 370
ASP B 356
VAL B 320
THR B 314
None
1.09A 4lnwA-4g7eB:
undetectable
4lnwA-4g7eB:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASP A 179
GLN A 217
VAL A 186
THR A 185
None
1.02A 4lnwA-4gisA:
undetectable
4lnwA-4gisA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkt INOSITOL
2-DEHYDROGENASE


(Sinorhizobium
meliloti)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 SER A 150
ASP A 175
GLN A 237
MET A 129
None
None
None
EDO  A 407 (-4.7A)
1.09A 4lnwA-4hktA:
undetectable
4lnwA-4hktA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwu FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Mus musculus)
PF13927
(Ig_3)
4 ASP A  66
VAL A 113
THR A 112
ARG A 111
None
0.98A 4lnwA-4hwuA:
undetectable
4lnwA-4hwuA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1
ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2


(Lactobacillus
brevis)
PF00005
(ABC_tran)
4 ASP A 240
GLU B 207
GLN B 205
THR A 168
None
1.04A 4lnwA-4hzuA:
undetectable
4lnwA-4hzuA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1


(Staphylococcus
aureus)
PF13614
(AAA_31)
4 SER A1048
GLU A1049
VAL A1058
THR A1057
ADP  A1301 ( 4.5A)
None
None
ADP  A1301 (-3.8A)
0.78A 4lnwA-4jlvA:
undetectable
4lnwA-4jlvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC


([Bacillus]
selenitireducens)
PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N)
4 GLU A 640
VAL A 724
THR A 725
ARG A 761
None
1.13A 4lnwA-4ktpA:
undetectable
4lnwA-4ktpA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE


(Homo sapiens)
PF01008
(IF-2B)
4 ASP A 248
GLU A 298
MET A  96
VAL A  94
None
1.03A 4lnwA-4ldqA:
undetectable
4lnwA-4ldqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx2 ADENYLOSUCCINATE
LYASE


(Leishmania
donovani)
PF00206
(Lyase_1)
PF08328
(ASL_C)
4 SER A 357
ASP A 362
VAL A 368
THR A 367
None
None
None
AMP  A 501 (-4.4A)
1.12A 4lnwA-4mx2A:
undetectable
4lnwA-4mx2A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24


(Homo sapiens)
PF00069
(Pkinase)
4 ASP B  66
GLU B 178
VAL B  73
THR B  72
None
1.14A 4lnwA-4o27B:
undetectable
4lnwA-4o27B:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN


(Pyrococcus
horikoshii)
PF00375
(SDF)
4 GLU A 291
MET A 399
VAL A 402
THR A 403
None
1.15A 4lnwA-4oyeA:
undetectable
4lnwA-4oyeA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psd CARBOHYDRATE
ESTERASE FAMILY 5


(Trichoderma
reesei)
PF01083
(Cutinase)
4 SER A 167
ASP A 193
VAL A 188
THR A 208
None
1.13A 4lnwA-4psdA:
undetectable
4lnwA-4psdA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5


(Bacteroides
vulgatus)
PF12904
(Collagen_bind_2)
PF13204
(DUF4038)
4 SER A 430
ASP A 433
GLN A 461
THR A 478
None
1.01A 4lnwA-4qfuA:
undetectable
4lnwA-4qfuA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0c ABGT PUTATIVE
TRANSPORTER FAMILY


(Alcanivorax
borkumensis)
PF03806
(ABG_transport)
4 ASP A 134
MET A 327
VAL A 329
THR A 330
None
LMT  A 806 ( 4.4A)
None
None
1.05A 4lnwA-4r0cA:
undetectable
4lnwA-4r0cA:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s15 NUCLEAR RECEPTOR
ROR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
4 GLU A 443
GLN A 446
VAL A 474
ARG A 478
None
0.92A 4lnwA-4s15A:
26.7
4lnwA-4s15A:
32.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A


(Pseudomonas
aeruginosa)
PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
4 SER A 197
ASP A 232
MET B  44
THR B  47
None
1.10A 4lnwA-4wj3A:
undetectable
4lnwA-4wj3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE


(Homo sapiens)
PF02350
(Epimerase_2)
4 SER A 139
ASP A 144
VAL A 222
THR A 224
None
1.13A 4lnwA-4zhtA:
undetectable
4lnwA-4zhtA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila)
no annotation 4 SER A 154
GLU A 156
THR A 476
ARG A 477
None
1.10A 4lnwA-4zuzA:
undetectable
4lnwA-4zuzA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdf ATP SYNTHASE SUBUNIT
BETA


(Paracoccus
denitrificans)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
4 ASP E 252
GLN E 217
MET E 226
VAL E 228
None
0.99A 4lnwA-5cdfE:
undetectable
4lnwA-5cdfE:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2


(Rickettsia
typhi)
PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31)
4 SER A 122
GLN A 129
VAL A 148
THR A 294
None
1.09A 4lnwA-5dooA:
undetectable
4lnwA-5dooA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC


(Bacillus
subtilis)
PF00698
(Acyl_transf_1)
4 GLN A 134
MET A 182
VAL A 180
THR A 181
None
1.09A 4lnwA-5dz6A:
undetectable
4lnwA-5dz6A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5o NUCLEOPROTEIN

(Marburg
marburgvirus)
PF05505
(Ebola_NP)
4 SER A 217
GLN A 220
VAL A 160
THR A 159
None
0.90A 4lnwA-5f5oA:
undetectable
4lnwA-5f5oA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1


(Oryctolagus
cuniculus)
PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2)
4 SER F 884
MET F 851
VAL F1021
ARG F1004
None
1.15A 4lnwA-5gjwF:
undetectable
4lnwA-5gjwF:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1


(Homo sapiens)
PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M)
4 ASP A 258
GLN A 455
VAL A 394
THR A 395
None
1.16A 4lnwA-5hp5A:
undetectable
4lnwA-5hp5A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11


(Homo sapiens)
PF00017
(SH2)
PF00102
(Y_phosphatase)
4 SER A 460
ASP A  61
GLU A 361
THR A 468
None
0.89A 4lnwA-5i6vA:
undetectable
4lnwA-5i6vA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila)
PF00326
(Peptidase_S9)
4 SER A 247
GLN A 249
VAL A 202
THR A 178
None
1.15A 4lnwA-5l8sA:
undetectable
4lnwA-5l8sA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE


(Pseudomonas
aeruginosa)
PF00795
(CN_hydrolase)
4 SER A 405
ASP A 407
MET A 425
ARG A 436
None
0.80A 4lnwA-5n6mA:
undetectable
4lnwA-5n6mA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster)
no annotation 4 SER A 576
ASP A 637
GLU A 575
VAL A 285
None
U  C   7 ( 4.8A)
None
None
1.13A 4lnwA-5n94A:
undetectable
4lnwA-5n94A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1)
no annotation 4 SER A 729
GLU A 688
VAL A 558
THR A 557
None
0.92A 4lnwA-5nd1A:
undetectable
4lnwA-5nd1A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN


(Campylobacter
jejuni)
PF13343
(SBP_bac_6)
4 SER A  38
ASP A  65
GLU A  73
THR A  51
None
None
GPE  A 402 ( 4.6A)
None
1.10A 4lnwA-5t1pA:
undetectable
4lnwA-5t1pA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4y SUSC HOMOLOG

(Bacteroides
thetaiotaomicron)
no annotation 4 SER D 556
ASP D 578
GLU D 510
THR D 574
None
1.16A 4lnwA-5t4yD:
undetectable
4lnwA-5t4yD:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE


(Malbranchea
aurantiaca)
PF04820
(Trp_halogenase)
4 ASP A 292
MET A 281
VAL A 284
THR A 285
None
0.96A 4lnwA-5wgxA:
undetectable
4lnwA-5wgxA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE


(Escherichia
coli)
PF00795
(CN_hydrolase)
4 SER A 411
ASP A 413
MET A 431
ARG A 442
None
1.16A 4lnwA-5xhqA:
undetectable
4lnwA-5xhqA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsq NUCLEOPROTEIN

(Marburg
marburgvirus)
PF05505
(Ebola_NP)
4 SER A 201
GLN A 204
VAL A 144
THR A 143
None
0.83A 4lnwA-5xsqA:
undetectable
4lnwA-5xsqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zov -

(-)
no annotation 4 GLU A 391
GLN A 337
VAL A 239
THR A 236
None
0.88A 4lnwA-5zovA:
undetectable
4lnwA-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5


(Aquareovirus C)
no annotation 4 SER 4 475
ASP 4 482
VAL 4 488
THR 4 487
None
0.91A 4lnwA-5zvs4:
undetectable
4lnwA-5zvs4:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu9 RETINOIC ACID
RECEPTOR


(Platynereis
dumerilii)
no annotation 4 SER A 464
ASP A 466
GLN A 480
THR A 510
None
0.99A 4lnwA-6eu9A:
28.4
4lnwA-6eu9A:
29.25