SIMILAR PATTERNS OF AMINO ACIDS FOR 4LNW_A_T3A501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b69 PROTEIN (INTEGRASE)

(Enterococcus
faecalis) 		PF02920
(Integrase_DNA) 		5 ILE A  58
ALA A  57
LEU A  60
SER A  41
LEU A  67
 None
 1.16A 4lnwA-1b69A:
undetectable		 4lnwA-1b69A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsl BACTERIAL LUCIFERASE

(Vibrio harveyi) 		PF00296
(Bac_luciferase) 		5 ARG A  15
ALA A 243
LEU A 247
ILE A 273
PHE A   6
 None
 1.07A 4lnwA-1bslA:
0.0		 4lnwA-1bslA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN

(Cricetulus
griseus) 		PF00004
(AAA) 		5 ILE A 702
ALA A 703
LEU A 718
ILE A 678
PHE A 694
 None
 1.15A 4lnwA-1d2nA:
0.4		 4lnwA-1d2nA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 5 ILE B 743
ALA B 594
LEU B 595
LEU B 886
ILE B 882
 None
 0.82A 4lnwA-1ej6B:
1.2		 4lnwA-1ej6B:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU)
PF02287
(Dehydratase_SU) 		5 ALA A 221
MET A 214
ALA A 249
LEU A 246
ILE G  87
 None
 1.12A 4lnwA-1iwpA:
0.0		 4lnwA-1iwpA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 ILE A  24
ALA A  25
ARG A  83
ILE A 348
HIS A 362
 None
 1.10A 4lnwA-1jaeA:
0.0		 4lnwA-1jaeA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 5 MET T  52
ALA T  26
LEU T  22
LEU T  37
ILE T  35
 None
 1.14A 4lnwA-1lthT:
0.0		 4lnwA-1lthT:
23.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 222
ALA A 225
ARG A 228
MET A 256
ALA A 263
LEU A 276
SER A 277
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.3A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 0.77A 4lnwA-1navA:
37.5		 4lnwA-1navA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ILE A 222
ALA A 225
LEU A 292
ILE A 377
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.7A)
None
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 1.28A 4lnwA-1navA:
37.5		 4lnwA-1navA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 ILE A  24
ALA A  25
ARG A  85
ILE A 372
HIS A 386
 None
 1.13A 4lnwA-1oseA:
0.0		 4lnwA-1oseA:
17.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ILE A 276
ALA A 279
ARG A 282
ALA A 317
LEU A 341
ILE A 353
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 4.1A)
None
None
 1.35A 4lnwA-1q4xA:
36.7		 4lnwA-1q4xA:
81.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 ILE A 276
ALA A 279
ARG A 282
MET A 310
ALA A 317
LEU A 330
LEU A 346
ILE A 353
HIS A 435
PHE A 455
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.1A)
G24  A 462 ( 3.9A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.52A 4lnwA-1q4xA:
36.7		 4lnwA-1q4xA:
81.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5t DIHYDRODIPICOLINATE
SYNTHASE

(Escherichia
coli) 		PF00701
(DHDPS) 		5 ALA A 207
ALA A  38
SER A   5
LEU A 101
ILE A  74
 None
 1.17A 4lnwA-1s5tA:
undetectable		 4lnwA-1s5tA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL

(Pyrobaculum
aerophilum) 		PF10432
(bact-PGI_C) 		5 ILE A 155
ALA A 150
ALA A 145
LEU A 146
ILE A  42
 None
 1.11A 4lnwA-1tzbA:
undetectable		 4lnwA-1tzbA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE

(Streptococcus
pneumoniae) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 ILE A 270
ALA A 263
ALA A 326
LEU A 306
ILE A 323
 None
 1.01A 4lnwA-1vqzA:
undetectable		 4lnwA-1vqzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wod MODA

(Escherichia
coli) 		PF13531
(SBP_bac_11) 		5 ALA A  10
ALA A  16
SER A  12
LEU A 216
ILE A  20
 WO4  A 234 (-3.3A)
None
WO4  A 234 ( 2.7A)
None
None
 1.14A 4lnwA-1wodA:
undetectable		 4lnwA-1wodA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 ALA A  75
ALA A 328
LEU A  70
LEU A  53
ILE A 339
 None
 1.10A 4lnwA-1x8vA:
undetectable		 4lnwA-1x8vA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yoz HYPOTHETICAL PROTEIN
AF0941

(Archaeoglobus
fulgidus) 		PF14591
(AF0941-like) 		5 ILE A  43
ALA A  34
LEU A  38
ILE A  24
PHE A  47
 None
 1.12A 4lnwA-1yozA:
undetectable		 4lnwA-1yozA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqq XANTHOSINE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		5 ALA A  66
ALA A  40
LEU A  32
ILE A  43
PHE A  57
 None
 1.12A 4lnwA-1yqqA:
undetectable		 4lnwA-1yqqA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1

(Pseudomonas
aeruginosa) 		PF04166
(PdxA) 		5 ILE A1125
ALA A1093
ALA A1013
LEU A1088
PHE A1132
 None
 1.14A 4lnwA-1yxoA:
undetectable		 4lnwA-1yxoA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))

(Streptococcus
pyogenes) 		PF00390
(malic)
PF03949
(Malic_M) 		5 ILE A 191
ALA A 209
LEU A 172
ILE A 346
PHE A 262
 None
 1.08A 4lnwA-2a9fA:
undetectable		 4lnwA-2a9fA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aua HYPOTHETICAL PROTEIN

(Bacillus cereus) 		PF10386
(DUF2441) 		5 ILE A  11
ALA A 116
ALA A   8
ILE A 182
PHE A 123
 None
 1.16A 4lnwA-2auaA:
undetectable		 4lnwA-2auaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d57 AQUAPORIN-4

(Rattus
norvegicus) 		PF00230
(MIP) 		5 ILE A  81
ALA A  82
ILE A 199
HIS A 201
PHE A  48
 None
 1.08A 4lnwA-2d57A:
undetectable		 4lnwA-2d57A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B

(Pyrococcus
horikoshii) 		PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 ILE A 182
ALA A 173
ALA A  36
LEU A  27
ILE A  25
 None
 1.07A 4lnwA-2dplA:
undetectable		 4lnwA-2dplA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		5 ILE A 246
ALA A 245
ALA A 238
LEU A 265
PHE A 329
 None
None
XTS  A 502 ( 4.3A)
None
None
 1.08A 4lnwA-2eg5A:
undetectable		 4lnwA-2eg5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehh DIHYDRODIPICOLINATE
SYNTHASE

(Aquifex
aeolicus) 		PF00701
(DHDPS) 		5 ILE A  59
ALA A  96
ALA A  66
LEU A  23
ILE A  27
 None
 1.04A 4lnwA-2ehhA:
undetectable		 4lnwA-2ehhA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ALA A 159
ALA A 221
LEU A 215
LEU A 192
ILE A 225
 None
 1.17A 4lnwA-2fymA:
undetectable		 4lnwA-2fymA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9h EXTRACELLULAR
ENTEROTOXIN TYPE I

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 ILE D 139
LEU D 129
LEU D  99
ILE D 108
PHE D 161
 None
 1.11A 4lnwA-2g9hD:
undetectable		 4lnwA-2g9hD:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gas ISOFLAVONE REDUCTASE

(Medicago sativa) 		PF05368
(NmrA) 		5 ILE A 110
ALA A 113
ALA A  84
LEU A  81
LEU A  10
 None
 1.15A 4lnwA-2gasA:
undetectable		 4lnwA-2gasA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A 115
ALA A  43
LEU A  91
LEU A  78
ILE A  45
 None
 1.14A 4lnwA-2i6uA:
undetectable		 4lnwA-2i6uA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A 115
LEU A  91
SER A  92
LEU A  78
ILE A  45
 None
 1.04A 4lnwA-2i6uA:
undetectable		 4lnwA-2i6uA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		5 ILE A 154
ALA A 157
ALA A 206
LEU A 202
MET A 263
 None
 1.04A 4lnwA-2ivpA:
undetectable		 4lnwA-2ivpA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jrb ORF 1 PROTEIN

(Mus musculus) 		PF17490
(Tnp_22_dsRBD) 		5 ILE A 352
ALA A 348
LEU A 343
LEU A 307
ILE A 324
 None
 1.02A 4lnwA-2jrbA:
undetectable		 4lnwA-2jrbA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00497
(SBP_bac_3) 		6 ALA A 209
MET A  37
ALA A  66
LEU A 199
LEU A  87
ILE A  68
 None
 1.42A 4lnwA-2laoA:
undetectable		 4lnwA-2laoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ma9 TRANSCRIPTION
ELONGATION FACTOR B
POLYPEPTIDE 1
VIRION INFECTIVITY
FACTOR

(Homo sapiens;
Human
immunodeficiency
virus 1) 		PF00559
(Vif)
PF03931
(Skp1_POZ) 		5 ALA C  26
LEU A   8
SER A   7
LEU C  52
ILE C  47
 None
 1.14A 4lnwA-2ma9C:
undetectable		 4lnwA-2ma9C:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgw MUCONATE
CYCLOISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 180
ALA A 155
LEU A 143
LEU A 193
ILE A 188
 None
 1.12A 4lnwA-2pgwA:
undetectable		 4lnwA-2pgwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A  96
ALA A 131
ALA A  65
LEU A  33
ILE A  67
 None
 1.11A 4lnwA-2pp3A:
undetectable		 4lnwA-2pp3A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwq UBIQUITIN
CONJUGATING ENZYME

(Plasmodium
yoelii) 		PF00179
(UQ_con) 		5 ILE A  86
LEU A  91
LEU A 105
ILE A 101
PHE A  70
 None
 1.15A 4lnwA-2pwqA:
undetectable		 4lnwA-2pwqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ILE A  98
ALA A  65
ALA A 115
SER A  46
LEU A 132
 None
 1.15A 4lnwA-2qygA:
undetectable		 4lnwA-2qygA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		5 ALA A  98
ALA A 199
LEU A 292
ILE A 280
HIS A 295
 None
 1.02A 4lnwA-2w8qA:
undetectable		 4lnwA-2w8qA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		5 ILE B 478
ALA B 468
LEU B 588
ILE B 599
PHE B 577
 None
 1.09A 4lnwA-2xfgB:
undetectable		 4lnwA-2xfgB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ILE A  80
ALA A  81
ARG A  85
LEU A 107
ILE A 262
 None
 1.17A 4lnwA-3cmuA:
undetectable		 4lnwA-3cmuA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ILE A2080
ALA A2081
ARG A2085
LEU A2107
ILE A2262
 None
 1.17A 4lnwA-3cmuA:
undetectable		 4lnwA-3cmuA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ILE A5080
ALA A5081
ARG A5085
LEU A5107
ILE A5262
 None
 1.17A 4lnwA-3cmuA:
undetectable		 4lnwA-3cmuA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		5 ALA A  27
ARG A  30
ALA A 228
LEU A 144
ILE A 187
 None
 1.15A 4lnwA-3ek2A:
undetectable		 4lnwA-3ek2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE A  90
ALA A  51
LEU A 112
LEU A  34
ILE A  73
 None
 1.05A 4lnwA-3hveA:
undetectable		 4lnwA-3hveA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuv UNCHARACTERIZED TETR
FAMILY PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 ILE A  13
ALA A  16
ARG A  19
LEU A  42
HIS A  31
 None
 1.14A 4lnwA-3iuvA:
undetectable		 4lnwA-3iuvA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
avermitilis) 		PF00440
(TetR_N) 		5 ALA A  17
ALA A  56
LEU A  59
SER A  58
LEU A 112
 None
 1.17A 4lnwA-3jsjA:
undetectable		 4lnwA-3jsjA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzb NICKEL-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 ILE A 470
LEU A 242
SER A 243
LEU A 226
MET A 356
 None
GOL  A 527 (-4.0A)
GOL  A 512 (-3.6A)
None
None
 0.97A 4lnwA-3mzbA:
undetectable		 4lnwA-3mzbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot5 UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Listeria
monocytogenes) 		PF02350
(Epimerase_2) 		5 ILE A   4
ALA A  25
LEU A  26
LEU A  95
PHE A 368
 None
 1.10A 4lnwA-3ot5A:
undetectable		 4lnwA-3ot5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 ILE A  12
ALA A  76
SER A  10
LEU A 147
ILE A 188
 None
 1.07A 4lnwA-3ppiA:
undetectable		 4lnwA-3ppiA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 ILE A 846
ALA A 767
LEU A 751
LEU A 799
ILE A 782
 None
 1.14A 4lnwA-3psfA:
undetectable		 4lnwA-3psfA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 ILE A 846
ALA A 767
LEU A 751
LEU A 799
ILE A 782
 None
 1.14A 4lnwA-3psiA:
undetectable		 4lnwA-3psiA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		5 ALA A 322
ARG A 249
ALA A 316
LEU A 342
ILE A 306
 None
 1.10A 4lnwA-3tp9A:
undetectable		 4lnwA-3tp9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		5 ALA A 143
ALA A 157
LEU A 153
SER A 154
LEU A 133
 None
 1.16A 4lnwA-3tqsA:
undetectable		 4lnwA-3tqsA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u80 3-DEHYDROQUINATE
DEHYDRATASE, TYPE II

(Bifidobacterium
longum) 		PF01220
(DHquinase_II) 		5 ILE A   5
ALA A  64
MET A  57
ALA A  89
LEU A  99
 None
 1.10A 4lnwA-3u80A:
undetectable		 4lnwA-3u80A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		5 ILE A 247
ALA A 222
ALA A 150
LEU A 132
ILE A 138
 None
 1.17A 4lnwA-3uqzA:
undetectable		 4lnwA-3uqzA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 ILE A  24
ALA A  25
ARG A  85
ILE A 373
HIS A 387
 None
 1.14A 4lnwA-3vm5A:
undetectable		 4lnwA-3vm5A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ALA A 156
ALA A 218
LEU A 212
LEU A 189
ILE A 222
 None
 1.16A 4lnwA-4a3rA:
undetectable		 4lnwA-4a3rA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 5 ILE A 535
ALA A 574
LEU A 523
HIS A 560
PHE A   7
 None
 1.13A 4lnwA-4bb9A:
undetectable		 4lnwA-4bb9A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 ILE B1701
ALA B1702
SER B1869
LEU B1745
HIS B1748
 None
 1.17A 4lnwA-4bedB:
undetectable		 4lnwA-4bedB:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ARG A 309
ALA A 155
LEU A 156
LEU A  18
ILE A  95
 None
 1.15A 4lnwA-4cokA:
undetectable		 4lnwA-4cokA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ILE A 870
ALA A 869
ALA A1047
LEU A 829
ILE A1051
 None
 1.06A 4lnwA-4f4cA:
undetectable		 4lnwA-4f4cA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ILE A1272
ALA A1286
LEU A1108
LEU A1098
ILE A1293
 None
 1.12A 4lnwA-4f4cA:
undetectable		 4lnwA-4f4cA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima) 		PF01706
(FliG_C)
PF14841
(FliG_M) 		5 ALA B 132
ALA B 201
LEU B 159
LEU B 227
ILE B 198
 None
 1.12A 4lnwA-4fhrB:
undetectable		 4lnwA-4fhrB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1

(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		no annotation 5 ILE B 200
ALA B 290
LEU B 287
LEU B 238
ILE B 240
 None
 1.10A 4lnwA-4h2xB:
undetectable		 4lnwA-4h2xB:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB

(Staphylococcus
epidermidis) 		PF00083
(Sugar_tr) 		5 ILE A 248
ALA A 247
SER A 376
ILE A  56
PHE A 252
 None
 1.12A 4lnwA-4ldsA:
undetectable		 4lnwA-4ldsA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m29 BETA-XYLOSIDASE

(Caulobacter
vibrioides) 		PF01229
(Glyco_hydro_39) 		5 ALA A 222
ALA A 188
LEU A 104
ILE A 137
PHE A 225
 None
 1.17A 4lnwA-4m29A:
undetectable		 4lnwA-4m29A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA A 167
ARG A 153
ALA A 173
LEU A 223
ILE A 219
 25L  A1000 ( 4.4A)
25L  A1000 (-3.9A)
None
None
None
 1.13A 4lnwA-4o1oA:
undetectable		 4lnwA-4o1oA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q82 PHOSPHOLIPASE/CARBOX
YLESTERASE

(Haliangium
ochraceum) 		no annotation 5 ILE A 156
ALA A 153
ALA A 212
LEU A 190
LEU A 204
 None
 1.14A 4lnwA-4q82A:
undetectable		 4lnwA-4q82A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmg STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase) 		5 ILE A 180
ALA A 210
LEU A 265
ILE A 263
HIS A 190
 None
 1.03A 4lnwA-4qmgA:
undetectable		 4lnwA-4qmgA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		5 ILE A 432
ALA A 365
ALA A 358
LEU A  46
ILE A 137
 None
 1.07A 4lnwA-4rasA:
undetectable		 4lnwA-4rasA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvm CITRATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		5 ILE A 321
ALA A  80
ALA A 221
LEU A 225
ILE A 329
 None
 1.05A 4lnwA-4tvmA:
undetectable		 4lnwA-4tvmA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN

(Homo sapiens) 		PF10421
(OAS1_C) 		5 ILE A 108
LEU A 126
LEU A 118
ILE A 140
PHE A  49
 None
 1.11A 4lnwA-4xq7A:
undetectable		 4lnwA-4xq7A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfh DNA-BINDING PROTEIN
HU-ALPHA

(Escherichia
coli) 		PF00216
(Bac_DNA_binding) 		5 ILE A  32
ALA A  31
ALA A  24
ILE A  10
PHE A  50
 None
 1.02A 4lnwA-4yfhA:
undetectable		 4lnwA-4yfhA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zju ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Acinetobacter
baumannii) 		PF13561
(adh_short_C2) 		5 ALA A  29
ARG A  32
ALA A 231
LEU A 147
ILE A 190
 None
None
None
NAD  A 300 (-4.0A)
None
 1.16A 4lnwA-4zjuA:
undetectable		 4lnwA-4zjuA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0k LABDANE-RELATED
DITERPENE SYNTHASE

(Streptomyces
sp.) 		no annotation 5 ILE A 199
ALA A 300
LEU A 201
ILE A 304
PHE A 139
 None
 1.06A 4lnwA-5a0kA:
undetectable		 4lnwA-5a0kA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah4 DNA POLYMERASE III
SUBUNIT BETA

(Mycolicibacterium
smegmatis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 ILE A 165
ALA A 150
ALA A 212
LEU A 238
ILE A 240
 None
 1.07A 4lnwA-5ah4A:
undetectable		 4lnwA-5ah4A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah4 DNA POLYMERASE III
SUBUNIT BETA

(Mycolicibacterium
smegmatis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 ILE A 273
ALA A 271
MET A 297
ALA A 361
LEU A 338
 None
 1.12A 4lnwA-5ah4A:
undetectable		 4lnwA-5ah4A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce6 FACT-SPT16

(Cicer arietinum) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 ILE A  93
ARG A 113
LEU A  77
ILE A  23
PHE A  88
 None
 1.15A 4lnwA-5ce6A:
undetectable		 4lnwA-5ce6A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6

(Mus musculus) 		PF01663
(Phosphodiest) 		5 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
 None
 0.99A 4lnwA-5egeA:
undetectable		 4lnwA-5egeA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hra ASPARTATE/GLUTAMATE
RACEMASE

(Escherichia
coli) 		PF01177
(Asp_Glu_race) 		5 ILE A 104
ALA A 107
ARG A 110
ALA A 224
ILE A  22
 None
 1.12A 4lnwA-5hraA:
undetectable		 4lnwA-5hraA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		5 ILE A 183
ALA A 217
LEU A 213
LEU A 190
PHE A 177
 None
 1.16A 4lnwA-5k04A:
undetectable		 4lnwA-5k04A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 ILE A1871
ARG A2145
ALA A1994
LEU A1889
ILE A1898
 None
 1.17A 4lnwA-5m59A:
undetectable		 4lnwA-5m59A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3m PROTOCATECHUATE
DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF01977
(UbiD) 		5 ILE A 347
ALA A 346
ALA A 388
LEU A 400
ILE A 398
 None
 1.15A 4lnwA-5o3mA:
undetectable		 4lnwA-5o3mA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oon UNDECAPRENYL-DIPHOSP
HATASE

(Escherichia
coli) 		no annotation 5 ILE A 179
ARG A 261
ALA A 167
SER A 173
MET A 152
 None
 1.01A 4lnwA-5oonA:
undetectable		 4lnwA-5oonA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tz8 GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		PF00535
(Glycos_transf_2) 		5 ILE A 192
ALA A 189
MET A 183
ALA A 235
ILE A 232
 None
 1.01A 4lnwA-5tz8A:
undetectable		 4lnwA-5tz8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 ILE A 170
ALA A 173
ALA A 146
LEU A  98
ILE A 137
 None
 1.03A 4lnwA-5u4hA:
undetectable		 4lnwA-5u4hA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		5 ILE A 168
ALA A 171
ALA A 146
LEU A  98
ILE A 137
 None
 1.07A 4lnwA-5ujsA:
undetectable		 4lnwA-5ujsA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uzh NAFOA.00085.B

(Naegleria
fowleri) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A  82
ALA A  87
ALA A  50
LEU A  78
ILE A  41
 None
 1.10A 4lnwA-5uzhA:
undetectable		 4lnwA-5uzhA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7o NOSK

(Streptomyces
actuosus) 		PF12697
(Abhydrolase_6) 		5 ILE A  99
ALA A 113
LEU A 123
SER A 122
PHE A  46
 None
 1.13A 4lnwA-5v7oA:
undetectable		 4lnwA-5v7oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 ILE A 170
ALA A 137
LEU A 233
ILE A 235
PHE A 174
 None
 1.17A 4lnwA-5vemA:
undetectable		 4lnwA-5vemA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whr INDOLEAMINE
2,3-DIOXYGENASE 1

(Homo sapiens) 		no annotation 5 ILE A  42
ALA A  43
ALA A  79
LEU A  83
LEU A  65
 None
 1.04A 4lnwA-5whrA:
undetectable		 4lnwA-5whrA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ILE B 247
ALA B 229
ALA B 382
LEU B 249
LEU B 306
 None
 0.91A 4lnwA-5xogB:
undetectable		 4lnwA-5xogB:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF05214
(Baculo_p33) 		5 ALA A 202
ALA A 179
LEU A 216
ILE A 176
HIS A 172
 None
 1.03A 4lnwA-5xtoA:
undetectable		 4lnwA-5xtoA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		5 ILE A 312
ALA A 315
ALA A 247
SER A 245
ILE A 295
 None
 0.98A 4lnwA-5xwbA:
undetectable		 4lnwA-5xwbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa) 		no annotation 5 ILE A 130
ALA A 205
LEU A 160
ILE A 201
PHE A 128
 None
 1.08A 4lnwA-6amsA:
undetectable		 4lnwA-6amsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 5 ILE A 172
ALA A 175
ALA A 147
LEU A  99
PHE A 159
 None
 1.10A 4lnwA-6cn1A:
undetectable		 4lnwA-6cn1A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d47 BETA SLIDING CLAMP

(Mycobacterium
marinum) 		no annotation 5 ILE A 167
ALA A 152
ALA A 214
LEU A 240
ILE A 242
 None
 1.09A 4lnwA-6d47A:
undetectable		 4lnwA-6d47A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gun -

(-) 		no annotation 5 ILE A  87
ARG A 134
ALA A 164
LEU A 151
LEU A 107
 None
 1.17A 4lnwA-6gunA:
undetectable		 4lnwA-6gunA:
undetectable