SIMILAR PATTERNS OF AMINO ACIDS FOR 4LNW_A_T3A501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b69 PROTEIN (INTEGRASE)

(Enterococcus
faecalis) 		PF02920
(Integrase_DNA) 		5 ILE A  58
ALA A  57
LEU A  60
SER A  41
LEU A  67
 None
 1.16A 4lnwA-1b69A:
undetectable		 4lnwA-1b69A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsl BACTERIAL LUCIFERASE

(Vibrio harveyi) 		PF00296
(Bac_luciferase) 		5 ARG A  15
ALA A 243
LEU A 247
ILE A 273
PHE A   6
 None
 1.07A 4lnwA-1bslA:
0.0		 4lnwA-1bslA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN

(Cricetulus
griseus) 		PF00004
(AAA) 		5 ILE A 702
ALA A 703
LEU A 718
ILE A 678
PHE A 694
 None
 1.15A 4lnwA-1d2nA:
0.4		 4lnwA-1d2nA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 5 ILE B 743
ALA B 594
LEU B 595
LEU B 886
ILE B 882
 None
 0.82A 4lnwA-1ej6B:
1.2		 4lnwA-1ej6B:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU)
PF02287
(Dehydratase_SU) 		5 ALA A 221
MET A 214
ALA A 249
LEU A 246
ILE G  87
 None
 1.12A 4lnwA-1iwpA:
0.0		 4lnwA-1iwpA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 ILE A  24
ALA A  25
ARG A  83
ILE A 348
HIS A 362
 None
 1.10A 4lnwA-1jaeA:
0.0		 4lnwA-1jaeA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 5 MET T  52
ALA T  26
LEU T  22
LEU T  37
ILE T  35
 None
 1.14A 4lnwA-1lthT:
0.0		 4lnwA-1lthT:
23.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 222
ALA A 225
ARG A 228
MET A 256
ALA A 263
LEU A 276
SER A 277
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.3A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 0.77A 4lnwA-1navA:
37.5		 4lnwA-1navA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ILE A 222
ALA A 225
LEU A 292
ILE A 377
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.7A)
None
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 1.28A 4lnwA-1navA:
37.5		 4lnwA-1navA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 ILE A  24
ALA A  25
ARG A  85
ILE A 372
HIS A 386
 None
 1.13A 4lnwA-1oseA:
0.0		 4lnwA-1oseA:
17.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ILE A 276
ALA A 279
ARG A 282
ALA A 317
LEU A 341
ILE A 353
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 4.1A)
None
None
 1.35A 4lnwA-1q4xA:
36.7		 4lnwA-1q4xA:
81.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 ILE A 276
ALA A 279
ARG A 282
MET A 310
ALA A 317
LEU A 330
LEU A 346
ILE A 353
HIS A 435
PHE A 455
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.1A)
G24  A 462 ( 3.9A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.52A 4lnwA-1q4xA:
36.7		 4lnwA-1q4xA:
81.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5t DIHYDRODIPICOLINATE
SYNTHASE

(Escherichia
coli) 		PF00701
(DHDPS) 		5 ALA A 207
ALA A  38
SER A   5
LEU A 101
ILE A  74
 None
 1.17A 4lnwA-1s5tA:
undetectable		 4lnwA-1s5tA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL

(Pyrobaculum
aerophilum) 		PF10432
(bact-PGI_C) 		5 ILE A 155
ALA A 150
ALA A 145
LEU A 146
ILE A  42
 None
 1.11A 4lnwA-1tzbA:
undetectable		 4lnwA-1tzbA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE

(Streptococcus
pneumoniae) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 ILE A 270
ALA A 263
ALA A 326
LEU A 306
ILE A 323
 None
 1.01A 4lnwA-1vqzA:
undetectable		 4lnwA-1vqzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wod MODA

(Escherichia
coli) 		PF13531
(SBP_bac_11) 		5 ALA A  10
ALA A  16
SER A  12
LEU A 216
ILE A  20
 WO4  A 234 (-3.3A)
None
WO4  A 234 ( 2.7A)
None
None
 1.14A 4lnwA-1wodA:
undetectable		 4lnwA-1wodA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 ALA A  75
ALA A 328
LEU A  70
LEU A  53
ILE A 339
 None
 1.10A 4lnwA-1x8vA:
undetectable		 4lnwA-1x8vA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yoz HYPOTHETICAL PROTEIN
AF0941

(Archaeoglobus
fulgidus) 		PF14591
(AF0941-like) 		5 ILE A  43
ALA A  34
LEU A  38
ILE A  24
PHE A  47
 None
 1.12A 4lnwA-1yozA:
undetectable		 4lnwA-1yozA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqq XANTHOSINE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		5 ALA A  66
ALA A  40
LEU A  32
ILE A  43
PHE A  57
 None
 1.12A 4lnwA-1yqqA:
undetectable		 4lnwA-1yqqA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1

(Pseudomonas
aeruginosa) 		PF04166
(PdxA) 		5 ILE A1125
ALA A1093
ALA A1013
LEU A1088
PHE A1132
 None
 1.14A 4lnwA-1yxoA:
undetectable		 4lnwA-1yxoA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))

(Streptococcus
pyogenes) 		PF00390
(malic)
PF03949
(Malic_M) 		5 ILE A 191
ALA A 209
LEU A 172
ILE A 346
PHE A 262
 None
 1.08A 4lnwA-2a9fA:
undetectable		 4lnwA-2a9fA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aua HYPOTHETICAL PROTEIN

(Bacillus cereus) 		PF10386
(DUF2441) 		5 ILE A  11
ALA A 116
ALA A   8
ILE A 182
PHE A 123
 None
 1.16A 4lnwA-2auaA:
undetectable		 4lnwA-2auaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d57 AQUAPORIN-4

(Rattus
norvegicus) 		PF00230
(MIP) 		5 ILE A  81
ALA A  82
ILE A 199
HIS A 201
PHE A  48
 None
 1.08A 4lnwA-2d57A:
undetectable		 4lnwA-2d57A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B

(Pyrococcus
horikoshii) 		PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 ILE A 182
ALA A 173
ALA A  36
LEU A  27
ILE A  25
 None
 1.07A 4lnwA-2dplA:
undetectable		 4lnwA-2dplA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		5 ILE A 246
ALA A 245
ALA A 238
LEU A 265
PHE A 329
 None
None
XTS  A 502 ( 4.3A)
None
None
 1.08A 4lnwA-2eg5A:
undetectable		 4lnwA-2eg5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehh DIHYDRODIPICOLINATE
SYNTHASE

(Aquifex
aeolicus) 		PF00701
(DHDPS) 		5 ILE A  59
ALA A  96
ALA A  66
LEU A  23
ILE A  27
 None
 1.04A 4lnwA-2ehhA:
undetectable		 4lnwA-2ehhA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ALA A 159
ALA A 221
LEU A 215
LEU A 192
ILE A 225
 None
 1.17A 4lnwA-2fymA:
undetectable		 4lnwA-2fymA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9h EXTRACELLULAR
ENTEROTOXIN TYPE I

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 ILE D 139
LEU D 129
LEU D  99
ILE D 108
PHE D 161
 None
 1.11A 4lnwA-2g9hD:
undetectable		 4lnwA-2g9hD:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gas ISOFLAVONE REDUCTASE

(Medicago sativa) 		PF05368
(NmrA) 		5 ILE A 110
ALA A 113
ALA A  84
LEU A  81
LEU A  10
 None
 1.15A 4lnwA-2gasA:
undetectable		 4lnwA-2gasA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A 115
ALA A  43
LEU A  91
LEU A  78
ILE A  45
 None
 1.14A 4lnwA-2i6uA:
undetectable		 4lnwA-2i6uA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A 115
LEU A  91
SER A  92
LEU A  78
ILE A  45
 None
 1.04A 4lnwA-2i6uA:
undetectable		 4lnwA-2i6uA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		5 ILE A 154
ALA A 157
ALA A 206
LEU A 202
MET A 263
 None
 1.04A 4lnwA-2ivpA:
undetectable		 4lnwA-2ivpA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jrb ORF 1 PROTEIN

(Mus musculus) 		PF17490
(Tnp_22_dsRBD) 		5 ILE A 352
ALA A 348
LEU A 343
LEU A 307
ILE A 324
 None
 1.02A 4lnwA-2jrbA:
undetectable		 4lnwA-2jrbA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00497
(SBP_bac_3) 		6 ALA A 209
MET A  37
ALA A  66
LEU A 199
LEU A  87
ILE A  68
 None
 1.42A 4lnwA-2laoA:
undetectable		 4lnwA-2laoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ma9 TRANSCRIPTION
ELONGATION FACTOR B
POLYPEPTIDE 1
VIRION INFECTIVITY
FACTOR

(Homo sapiens;
Human
immunodeficiency
virus 1) 		PF00559
(Vif)
PF03931
(Skp1_POZ) 		5 ALA C  26
LEU A   8
SER A   7
LEU C  52
ILE C  47
 None
 1.14A 4lnwA-2ma9C:
undetectable		 4lnwA-2ma9C:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgw MUCONATE
CYCLOISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 180
ALA A 155
LEU A 143
LEU A 193
ILE A 188
 None
 1.12A 4lnwA-2pgwA:
undetectable		 4lnwA-2pgwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A  96
ALA A 131
ALA A  65
LEU A  33
ILE A  67
 None
 1.11A 4lnwA-2pp3A:
undetectable		 4lnwA-2pp3A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwq UBIQUITIN
CONJUGATING ENZYME

(Plasmodium
yoelii) 		PF00179
(UQ_con) 		5 ILE A  86
LEU A  91
LEU A 105
ILE A 101
PHE A  70
 None
 1.15A 4lnwA-2pwqA:
undetectable		 4lnwA-2pwqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ILE A  98
ALA A  65
ALA A 115
SER A  46
LEU A 132
 None
 1.15A 4lnwA-2qygA:
undetectable		 4lnwA-2qygA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		5 ALA A  98
ALA A 199
LEU A 292
ILE A 280
HIS A 295
 None
 1.02A 4lnwA-2w8qA:
undetectable		 4lnwA-2w8qA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		5 ILE B 478
ALA B 468
LEU B 588
ILE B 599
PHE B 577
 None
 1.09A 4lnwA-2xfgB:
undetectable		 4lnwA-2xfgB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ILE A  80
ALA A  81
ARG A  85
LEU A 107
ILE A 262
 None
 1.17A 4lnwA-3cmuA:
undetectable		 4lnwA-3cmuA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ILE A2080
ALA A2081
ARG A2085
LEU A2107
ILE A2262
 None
 1.17A 4lnwA-3cmuA:
undetectable		 4lnwA-3cmuA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ILE A5080
ALA A5081
ARG A5085
LEU A5107
ILE A5262
 None
 1.17A 4lnwA-3cmuA:
undetectable		 4lnwA-3cmuA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		5 ALA A  27
ARG A  30
ALA A 228
LEU A 144
ILE A 187
 None
 1.15A 4lnwA-3ek2A:
undetectable		 4lnwA-3ek2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE A  90
ALA A  51
LEU A 112
LEU A  34
ILE A  73
 None
 1.05A 4lnwA-3hveA:
undetectable		 4lnwA-3hveA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuv UNCHARACTERIZED TETR
FAMILY PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 ILE A  13
ALA A  16
ARG A  19
LEU A  42
HIS A  31
 None
 1.14A 4lnwA-3iuvA:
undetectable		 4lnwA-3iuvA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
avermitilis) 		PF00440
(TetR_N) 		5 ALA A  17
ALA A  56
LEU A  59
SER A  58
LEU A 112
 None
 1.17A 4lnwA-3jsjA:
undetectable		 4lnwA-3jsjA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzb NICKEL-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 ILE A 470
LEU A 242
SER A 243
LEU A 226
MET A 356
 None
GOL  A 527 (-4.0A)
GOL  A 512 (-3.6A)
None
None
 0.97A 4lnwA-3mzbA:
undetectable		 4lnwA-3mzbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot5 UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Listeria
monocytogenes) 		PF02350
(Epimerase_2) 		5 ILE A   4
ALA A  25
LEU A  26
LEU A  95
PHE A 368
 None
 1.10A 4lnwA-3ot5A:
undetectable		 4lnwA-3ot5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 ILE A  12
ALA A  76
SER A  10
LEU A 147
ILE A 188
 None
 1.07A 4lnwA-3ppiA:
undetectable		 4lnwA-3ppiA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 ILE A 846
ALA A 767
LEU A 751
LEU A 799
ILE A 782
 None
 1.14A 4lnwA-3psfA:
undetectable		 4lnwA-3psfA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 ILE A 846
ALA A 767
LEU A 751
LEU A 799
ILE A 782
 None
 1.14A 4lnwA-3psiA:
undetectable		 4lnwA-3psiA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		5 ALA A 322
ARG A 249
ALA A 316
LEU A 342
ILE A 306
 None
 1.10A 4lnwA-3tp9A:
undetectable		 4lnwA-3tp9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		5 ALA A 143
ALA A 157
LEU A 153
SER A 154
LEU A 133
 None
 1.16A 4lnwA-3tqsA:
undetectable		 4lnwA-3tqsA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u80 3-DEHYDROQUINATE
DEHYDRATASE, TYPE II

(Bifidobacterium
longum) 		PF01220
(DHquinase_II) 		5 ILE A   5
ALA A  64
MET A  57
ALA A  89
LEU A  99
 None
 1.10A 4lnwA-3u80A:
undetectable		 4lnwA-3u80A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		5 ILE A 247
ALA A 222
ALA A 150
LEU A 132
ILE A 138
 None
 1.17A 4lnwA-3uqzA:
undetectable		 4lnwA-3uqzA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 ILE A  24
ALA A  25
ARG A  85
ILE A 373
HIS A 387
 None
 1.14A 4lnwA-3vm5A:
undetectable		 4lnwA-3vm5A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ALA A 156
ALA A 218
LEU A 212
LEU A 189
ILE A 222
 None
 1.16A 4lnwA-4a3rA:
undetectable		 4lnwA-4a3rA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 5 ILE A 535
ALA A 574
LEU A 523
HIS A 560
PHE A   7
 None
 1.13A 4lnwA-4bb9A:
undetectable		 4lnwA-4bb9A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 ILE B1701
ALA B1702
SER B1869
LEU B1745
HIS B1748
 None
 1.17A 4lnwA-4bedB:
undetectable		 4lnwA-4bedB:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ARG A 309
ALA A 155
LEU A 156
LEU A  18
ILE A  95
 None
 1.15A 4lnwA-4cokA:
undetectable		 4lnwA-4cokA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ILE A 870
ALA A 869
ALA A1047
LEU A 829
ILE A1051
 None
 1.06A 4lnwA-4f4cA:
undetectable		 4lnwA-4f4cA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ILE A1272
ALA A1286
LEU A1108
LEU A1098
ILE A1293
 None
 1.12A 4lnwA-4f4cA:
undetectable		 4lnwA-4f4cA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima) 		PF01706
(FliG_C)
PF14841
(FliG_M) 		5 ALA B 132
ALA B 201
LEU B 159
LEU B 227
ILE B 198
 None
 1.12A 4lnwA-4fhrB:
undetectable		 4lnwA-4fhrB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1

(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		no annotation 5 ILE B 200
ALA B 290
LEU B 287
LEU B 238
ILE B 240
 None
 1.10A 4lnwA-4h2xB:
undetectable		 4lnwA-4h2xB:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB

(Staphylococcus
epidermidis) 		PF00083
(Sugar_tr) 		5 ILE A 248
ALA A 247
SER A 376
ILE A  56
PHE A 252
 None
 1.12A 4lnwA-4ldsA:
undetectable		 4lnwA-4ldsA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m29 BETA-XYLOSIDASE

(Caulobacter
vibrioides) 		PF01229
(Glyco_hydro_39) 		5 ALA A 222
ALA A 188
LEU A 104
ILE A 137
PHE A 225
 None
 1.17A 4lnwA-4m29A:
undetectable		 4lnwA-4m29A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA A 167
ARG A 153
ALA A 173
LEU A 223
ILE A 219
 25L  A1000 ( 4.4A)
25L  A1000 (-3.9A)
None
None
None
 1.13A 4lnwA-4o1oA:
undetectable		 4lnwA-4o1oA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q82 PHOSPHOLIPASE/CARBOX
YLESTERASE

(Haliangium
ochraceum) 		no annotation 5 ILE A 156
ALA A 153
ALA A 212
LEU A 190
LEU A 204
 None
 1.14A 4lnwA-4q82A:
undetectable		 4lnwA-4q82A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmg STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase) 		5 ILE A 180
ALA A 210
LEU A 265
ILE A 263
HIS A 190
 None
 1.03A 4lnwA-4qmgA:
undetectable		 4lnwA-4qmgA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		5 ILE A 432
ALA A 365
ALA A 358
LEU A  46
ILE A 137
 None
 1.07A 4lnwA-4rasA:
undetectable		 4lnwA-4rasA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvm CITRATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		5 ILE A 321
ALA A  80
ALA A 221
LEU A 225
ILE A 329
 None
 1.05A 4lnwA-4tvmA:
undetectable		 4lnwA-4tvmA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN

(Homo sapiens) 		PF10421
(OAS1_C) 		5 ILE A 108
LEU A 126
LEU A 118
ILE A 140
PHE A  49
 None
 1.11A 4lnwA-4xq7A:
undetectable		 4lnwA-4xq7A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfh DNA-BINDING PROTEIN
HU-ALPHA

(Escherichia
coli) 		PF00216
(Bac_DNA_binding) 		5 ILE A  32
ALA A  31
ALA A  24
ILE A  10
PHE A  50
 None
 1.02A 4lnwA-4yfhA:
undetectable		 4lnwA-4yfhA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zju ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Acinetobacter
baumannii) 		PF13561
(adh_short_C2) 		5 ALA A  29
ARG A  32
ALA A 231
LEU A 147
ILE A 190
 None
None
None
NAD  A 300 (-4.0A)
None
 1.16A 4lnwA-4zjuA:
undetectable		 4lnwA-4zjuA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0k LABDANE-RELATED
DITERPENE SYNTHASE

(Streptomyces
sp.) 		no annotation 5 ILE A 199
ALA A 300
LEU A 201
ILE A 304
PHE A 139
 None
 1.06A 4lnwA-5a0kA:
undetectable		 4lnwA-5a0kA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah4 DNA POLYMERASE III
SUBUNIT BETA

(Mycolicibacterium
smegmatis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 ILE A 165
ALA A 150
ALA A 212
LEU A 238
ILE A 240
 None
 1.07A 4lnwA-5ah4A:
undetectable		 4lnwA-5ah4A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah4 DNA POLYMERASE III
SUBUNIT BETA

(Mycolicibacterium
smegmatis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 ILE A 273
ALA A 271
MET A 297
ALA A 361
LEU A 338
 None
 1.12A 4lnwA-5ah4A:
undetectable		 4lnwA-5ah4A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce6 FACT-SPT16

(Cicer arietinum) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 ILE A  93
ARG A 113
LEU A  77
ILE A  23
PHE A  88
 None
 1.15A 4lnwA-5ce6A:
undetectable		 4lnwA-5ce6A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6

(Mus musculus) 		PF01663
(Phosphodiest) 		5 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
 None
 0.99A 4lnwA-5egeA:
undetectable		 4lnwA-5egeA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hra ASPARTATE/GLUTAMATE
RACEMASE

(Escherichia
coli) 		PF01177
(Asp_Glu_race) 		5 ILE A 104
ALA A 107
ARG A 110
ALA A 224
ILE A  22
 None
 1.12A 4lnwA-5hraA:
undetectable		 4lnwA-5hraA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		5 ILE A 183
ALA A 217
LEU A 213
LEU A 190
PHE A 177
 None
 1.16A 4lnwA-5k04A:
undetectable		 4lnwA-5k04A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 ILE A1871
ARG A2145
ALA A1994
LEU A1889
ILE A1898
 None
 1.17A 4lnwA-5m59A:
undetectable		 4lnwA-5m59A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3m PROTOCATECHUATE
DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF01977
(UbiD) 		5 ILE A 347
ALA A 346
ALA A 388
LEU A 400
ILE A 398
 None
 1.15A 4lnwA-5o3mA:
undetectable		 4lnwA-5o3mA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oon UNDECAPRENYL-DIPHOSP
HATASE

(Escherichia
coli) 		no annotation 5 ILE A 179
ARG A 261
ALA A 167
SER A 173
MET A 152
 None
 1.01A 4lnwA-5oonA:
undetectable		 4lnwA-5oonA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tz8 GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		PF00535
(Glycos_transf_2) 		5 ILE A 192
ALA A 189
MET A 183
ALA A 235
ILE A 232
 None
 1.01A 4lnwA-5tz8A:
undetectable		 4lnwA-5tz8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 ILE A 170
ALA A 173
ALA A 146
LEU A  98
ILE A 137
 None
 1.03A 4lnwA-5u4hA:
undetectable		 4lnwA-5u4hA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		5 ILE A 168
ALA A 171
ALA A 146
LEU A  98
ILE A 137
 None
 1.07A 4lnwA-5ujsA:
undetectable		 4lnwA-5ujsA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uzh NAFOA.00085.B

(Naegleria
fowleri) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A  82
ALA A  87
ALA A  50
LEU A  78
ILE A  41
 None
 1.10A 4lnwA-5uzhA:
undetectable		 4lnwA-5uzhA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7o NOSK

(Streptomyces
actuosus) 		PF12697
(Abhydrolase_6) 		5 ILE A  99
ALA A 113
LEU A 123
SER A 122
PHE A  46
 None
 1.13A 4lnwA-5v7oA:
undetectable		 4lnwA-5v7oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 ILE A 170
ALA A 137
LEU A 233
ILE A 235
PHE A 174
 None
 1.17A 4lnwA-5vemA:
undetectable		 4lnwA-5vemA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whr INDOLEAMINE
2,3-DIOXYGENASE 1

(Homo sapiens) 		no annotation 5 ILE A  42
ALA A  43
ALA A  79
LEU A  83
LEU A  65
 None
 1.04A 4lnwA-5whrA:
undetectable		 4lnwA-5whrA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ILE B 247
ALA B 229
ALA B 382
LEU B 249
LEU B 306
 None
 0.91A 4lnwA-5xogB:
undetectable		 4lnwA-5xogB:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF05214
(Baculo_p33) 		5 ALA A 202
ALA A 179
LEU A 216
ILE A 176
HIS A 172
 None
 1.03A 4lnwA-5xtoA:
undetectable		 4lnwA-5xtoA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		5 ILE A 312
ALA A 315
ALA A 247
SER A 245
ILE A 295
 None
 0.98A 4lnwA-5xwbA:
undetectable		 4lnwA-5xwbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa) 		no annotation 5 ILE A 130
ALA A 205
LEU A 160
ILE A 201
PHE A 128
 None
 1.08A 4lnwA-6amsA:
undetectable		 4lnwA-6amsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 5 ILE A 172
ALA A 175
ALA A 147
LEU A  99
PHE A 159
 None
 1.10A 4lnwA-6cn1A:
undetectable		 4lnwA-6cn1A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d47 BETA SLIDING CLAMP

(Mycobacterium
marinum) 		no annotation 5 ILE A 167
ALA A 152
ALA A 214
LEU A 240
ILE A 242
 None
 1.09A 4lnwA-6d47A:
undetectable		 4lnwA-6d47A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gun -

(-) 		no annotation 5 ILE A  87
ARG A 134
ALA A 164
LEU A 151
LEU A 107
 None
 1.17A 4lnwA-6gunA:
undetectable		 4lnwA-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aow ANNEXIN IV

(Bos taurus) 		PF00191
(Annexin) 		3 ILE A 123
MET A  98
ARG A  95
 None
 0.92A 4lnwA-1aowA:
0.0		 4lnwA-1aowA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8k GENERAL
TRANSCRIPTION FACTOR
TFIIE-BETA

(Homo sapiens) 		PF02186
(TFIIE_beta) 		3 ILE A  68
MET A  20
ARG A  23
 None
 0.89A 4lnwA-1d8kA:
undetectable		 4lnwA-1d8kA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		3 ILE A 475
MET A 351
ARG A 362
 None
 0.79A 4lnwA-1dppA:
0.0		 4lnwA-1dppA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		3 ILE A  70
MET A  51
ARG A  52
 None
 0.86A 4lnwA-1kyhA:
0.0		 4lnwA-1kyhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 ILE A 299
MET A 290
ARG A 294
 None
 0.81A 4lnwA-1lnlA:
0.0		 4lnwA-1lnlA:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ILE A 221
MET A 259
ARG A 262
 None
IH5  A 600 (-4.7A)
None
 0.29A 4lnwA-1navA:
37.5		 4lnwA-1navA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pto PERTUSSIS TOXIN

(Bordetella
pertussis) 		PF02918
(Pertussis_S2S3)
PF03440
(APT) 		3 ILE B 189
MET B 145
ARG B 148
 None
 0.83A 4lnwA-1ptoB:
undetectable		 4lnwA-1ptoB:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ILE A 275
MET A 313
ARG A 316
 None
G24  A 462 ( 4.6A)
None
 0.39A 4lnwA-1q4xA:
36.7		 4lnwA-1q4xA:
81.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0o ECDYSONE RECEPTOR
ULTRASPIRACLE
PROTEIN

(Drosophila
melanogaster) 		PF00105
(zf-C4) 		3 ILE A  50
MET B  53
ARG B  57
 None
 0.78A 4lnwA-1r0oA:
undetectable		 4lnwA-1r0oA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		3 ILE A 117
MET A 101
ARG A 100
 None
 0.93A 4lnwA-1t9kA:
0.0		 4lnwA-1t9kA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450

(Sulfurisphaera
tokodaii) 		PF00067
(p450) 		3 ILE A 349
MET A 255
ARG A 256
 None
 0.82A 4lnwA-1ue8A:
undetectable		 4lnwA-1ue8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vh0 HYPOTHETICAL UPF0247
PROTEIN
SAV0024/SA0023

(Staphylococcus
aureus) 		PF02590
(SPOUT_MTase) 		3 ILE A   3
MET A 152
ARG A 153
 None
 0.92A 4lnwA-1vh0A:
undetectable		 4lnwA-1vh0A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wru 43 KDA TAIL PROTEIN

(Escherichia
virus Mu) 		PF05954
(Phage_GPD) 		3 ILE A  58
MET A 293
ARG A 286
 None
 0.92A 4lnwA-1wruA:
undetectable		 4lnwA-1wruA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II

(Sporidiobolus
salmonicolor) 		PF01370
(Epimerase) 		3 ILE A  91
MET A  72
ARG A  44
 NMN  A1001 (-4.9A)
AMP  A1002 (-3.5A)
AMP  A1002 ( 3.6A)
 0.86A 4lnwA-1y1pA:
undetectable		 4lnwA-1y1pA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb0 PROPHAGE LAMBDABA02,
N-ACETYLMURAMOYL-L-A
LANINE AMIDASE,
FAMILY 2

(Bacillus
anthracis) 		PF01510
(Amidase_2) 		3 ILE A 151
MET A 141
ARG A 146
 None
 0.85A 4lnwA-1yb0A:
undetectable		 4lnwA-1yb0A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytk NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE FROM
THERMOPLASMA
ACIDOPHILUM

(Thermoplasma
acidophilum) 		PF01729
(QRPTase_C) 		3 ILE A 295
MET A 150
ARG A 153
 None
 0.70A 4lnwA-1ytkA:
undetectable		 4lnwA-1ytkA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 ILE A1100
MET A1054
ARG A1057
 None
 0.82A 4lnwA-2b5mA:
undetectable		 4lnwA-2b5mA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01409
(tRNA-synt_2d) 		3 ILE A 380
MET A 408
ARG A 410
 None
 0.94A 4lnwA-2du3A:
undetectable		 4lnwA-2du3A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fli RIBULOSE-PHOSPHATE
3-EPIMERASE

(Streptococcus
pyogenes) 		PF00834
(Ribul_P_3_epim) 		3 ILE A  37
MET A  56
ARG A  57
 None
 0.86A 4lnwA-2fliA:
undetectable		 4lnwA-2fliA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fno AGR_PAT_752P

(Agrobacterium
fabrum) 		no annotation 3 ILE A 171
MET A  74
ARG A  18
 None
 0.64A 4lnwA-2fnoA:
undetectable		 4lnwA-2fnoA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h12 CITRATE SYNTHASE

(Acetobacter
aceti) 		PF00285
(Citrate_synt) 		3 ILE A 292
MET A 282
ARG A 285
 None
 0.92A 4lnwA-2h12A:
undetectable		 4lnwA-2h12A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivx CYCLIN-T2

(Homo sapiens) 		PF00134
(Cyclin_N) 		3 ILE A 104
MET A  47
ARG A  50
 None
 0.79A 4lnwA-2ivxA:
undetectable		 4lnwA-2ivxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ILE A  69
MET A 249
ARG A 419
 None
 0.93A 4lnwA-2ji9A:
undetectable		 4lnwA-2ji9A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1g PUTATIVE XYLANASE

(Bacteroides
fragilis) 		PF07313
(DUF1460) 		3 ILE A 195
MET A 241
ARG A 245
 None
 0.91A 4lnwA-2p1gA:
undetectable		 4lnwA-2p1gA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk2 CYCLIN-T1, PROTEIN
TAT

(Equine
infectious
anemia virus;
Homo sapiens) 		PF00134
(Cyclin_N) 		3 ILE A 105
MET A  48
ARG A  51
 ILE  A 105 ( 0.7A)
MET  A  48 ( 0.0A)
ARG  A  51 ( 0.6A)
 0.90A 4lnwA-2pk2A:
undetectable		 4lnwA-2pk2A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3z SMALL-INDUCIBLE
CYTOKINE B10

(Mus musculus) 		PF00048
(IL8) 		3 ILE A  61
MET A  21
ARG A  20
 None
 0.88A 4lnwA-2r3zA:
undetectable		 4lnwA-2r3zA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ILE A  18
MET A 143
ARG A 144
 None
 0.94A 4lnwA-2rgwA:
undetectable		 4lnwA-2rgwA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2riu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Candida
albicans) 		PF00926
(DHBP_synthase) 		3 ILE A 182
MET A 176
ARG A 169
 None
 0.89A 4lnwA-2riuA:
undetectable		 4lnwA-2riuA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vli ANTIBIOTIC
RESISTANCE PROTEIN

(Deinococcus
radiodurans) 		no annotation 3 ILE A  86
MET A  96
ARG A  93
 None
 0.88A 4lnwA-2vliA:
undetectable		 4lnwA-2vliA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp9 SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT

(Escherichia
coli) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		3 ILE B  40
MET B  33
ARG B  31
 None
 0.78A 4lnwA-2wp9B:
undetectable		 4lnwA-2wp9B:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE

(Bacillus
subtilis) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		3 ILE A 148
MET A 189
ARG A 190
 None
 0.66A 4lnwA-2x7jA:
undetectable		 4lnwA-2x7jA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpp IWS1

(Encephalitozoon
cuniculi) 		PF08711
(Med26) 		3 ILE A 136
MET A  70
ARG A  69
 None
 0.86A 4lnwA-2xppA:
undetectable		 4lnwA-2xppA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		3 ILE A 342
MET A 365
ARG A 368
 None
 0.94A 4lnwA-2zj8A:
undetectable		 4lnwA-2zj8A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjm PUTATIVE
BETA-LACTAMASE

(Enterococcus
faecalis) 		PF13354
(Beta-lactamase2) 		3 ILE A  85
MET A 245
ARG A 244
 None
None
EDO  A   6 ( 4.5A)
 0.87A 4lnwA-3cjmA:
undetectable		 4lnwA-3cjmA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		3 ILE A 222
MET A 186
ARG A 190
 None
 0.94A 4lnwA-3fefA:
undetectable		 4lnwA-3fefA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 ILE A 134
MET A 149
ARG A 178
 None
 0.87A 4lnwA-3fjoA:
undetectable		 4lnwA-3fjoA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		3 ILE A 176
MET A  72
ARG A  73
 None
 0.80A 4lnwA-3g5iA:
undetectable		 4lnwA-3g5iA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4

(Thermus
thermophilus) 		PF00346
(Complex1_49kDa) 		3 ILE 4  79
MET 4  70
ARG 4  73
 None
 0.91A 4lnwA-3i9v4:
undetectable		 4lnwA-3i9v4:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0x PROTEIN TEN1

(Schizosaccharomyces
pombe) 		PF12658
(Ten1) 		3 ILE A  86
MET A  94
ARG A  98
 None
 0.70A 4lnwA-3k0xA:
undetectable		 4lnwA-3k0xA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 ILE A 341
MET A 352
ARG A 381
 None
None
4AD  A 500 (-3.3A)
 0.87A 4lnwA-3m4pA:
undetectable		 4lnwA-3m4pA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		3 ILE A  97
MET A  88
ARG A  91
 None
 0.84A 4lnwA-3mduA:
undetectable		 4lnwA-3mduA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nad FERULATE
DECARBOXYLASE

(Bacillus
pumilus) 		PF05870
(PA_decarbox) 		3 ILE A  10
MET A  81
ARG A  80
 None
 0.94A 4lnwA-3nadA:
undetectable		 4lnwA-3nadA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox5 CALCIUM-BINDING
PROTEIN 1

(Homo sapiens) 		PF13499
(EF-hand_7) 		3 ILE A  42
MET A  51
ARG A  52
 None
 0.92A 4lnwA-3ox5A:
2.1		 4lnwA-3ox5A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE

(Methanocaldococcus
jannaschii) 		no annotation 3 ILE A 115
MET A 191
ARG A 194
 None
 0.84A 4lnwA-3s4lA:
undetectable		 4lnwA-3s4lA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 ILE A 212
MET A 318
ARG A 317
 None
 0.75A 4lnwA-3se7A:
undetectable		 4lnwA-3se7A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Toxoplasma
gondii) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 ILE A 119
MET A 133
ARG A 326
 None
 0.91A 4lnwA-3sthA:
undetectable		 4lnwA-3sthA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tni CYCLIN-T1

(Homo sapiens) 		PF00134
(Cyclin_N) 		3 ILE B 105
MET B  48
ARG B  51
 None
 0.83A 4lnwA-3tniB:
undetectable		 4lnwA-3tniB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ILE A 284
MET A 268
ARG A 271
 None
 0.93A 4lnwA-3tqpA:
undetectable		 4lnwA-3tqpA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2k DNA GYRASE SUBUNIT B

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		3 ILE A 102
MET A  94
ARG A  96
 None
 0.91A 4lnwA-3u2kA:
undetectable		 4lnwA-3u2kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		3 ILE A 140
MET A 487
ARG A 490
 None
 0.89A 4lnwA-3vilA:
undetectable		 4lnwA-3vilA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amq L544

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 3 ILE A 289
MET A   1
ARG A   0
 None
 0.82A 4lnwA-4amqA:
undetectable		 4lnwA-4amqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ast ALDO-KETO REDUCTASE
AKR14A1

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		3 ILE A 332
MET A 273
ARG A 277
 None
 0.94A 4lnwA-4astA:
undetectable		 4lnwA-4astA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxo FANCONI ANEMIA GROUP
M PROTEIN

(Homo sapiens) 		PF02732
(ERCC4) 		3 ILE A1930
MET A1861
ARG A1860
 None
 0.82A 4lnwA-4bxoA:
undetectable		 4lnwA-4bxoA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00701
(DHDPS) 		3 ILE A 261
MET A 276
ARG A  67
 None
 0.75A 4lnwA-4dppA:
undetectable		 4lnwA-4dppA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1b FLAVOHEMOGLOBIN

(Saccharomyces
cerevisiae) 		PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 ILE A  81
MET A 140
ARG A  86
 HEM  A 401 (-4.1A)
None
None
 0.91A 4lnwA-4g1bA:
undetectable		 4lnwA-4g1bA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8k 2-5A-DEPENDENT
RIBONUCLEASE

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		3 ILE A  30
MET A  69
ARG A  71
 None
 0.94A 4lnwA-4g8kA:
undetectable		 4lnwA-4g8kA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkl ALPHA-AMYLASE

(Thermotoga
neapolitana) 		PF00128
(Alpha-amylase) 		3 ILE A 274
MET A  37
ARG A 320
 None
 0.82A 4lnwA-4gklA:
undetectable		 4lnwA-4gklA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkl ALPHA-AMYLASE

(Thermotoga
neapolitana) 		PF00128
(Alpha-amylase) 		3 ILE A 315
MET A  37
ARG A 320
 None
 0.93A 4lnwA-4gklA:
undetectable		 4lnwA-4gklA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4had PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF01408
(GFO_IDH_MocA) 		3 ILE A  21
MET A  43
ARG A  46
 None
 0.94A 4lnwA-4hadA:
undetectable		 4lnwA-4hadA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis) 		PF00005
(ABC_tran) 		3 ILE A 154
MET A 179
ARG A 148
 None
 0.95A 4lnwA-4hzuA:
undetectable		 4lnwA-4hzuA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-1A

(Rattus
norvegicus) 		PF00804
(Syntaxin) 		3 ILE B  44
MET B 219
ARG B  90
 None
 0.81A 4lnwA-4jeuB:
undetectable		 4lnwA-4jeuB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		no annotation 3 ILE B  83
MET B 153
ARG B 359
 None
 0.78A 4lnwA-4lwoB:
undetectable		 4lnwA-4lwoB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6w FANCONI ANEMIA GROUP
M PROTEIN

(Homo sapiens) 		PF02732
(ERCC4) 		3 ILE A1930
MET A1861
ARG A1860
 None
None
SO4  A2102 ( 3.7A)
 0.72A 4lnwA-4m6wA:
undetectable		 4lnwA-4m6wA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8r HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF16023
(DUF4784) 		3 ILE A  54
MET A 102
ARG A 101
 None
 0.95A 4lnwA-4m8rA:
undetectable		 4lnwA-4m8rA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muo UNCHARACTERIZED
PROTEIN YBIB

(Escherichia
coli) 		PF02885
(Glycos_trans_3N) 		3 ILE A  47
MET A 171
ARG A 174
 None
 0.83A 4lnwA-4muoA:
undetectable		 4lnwA-4muoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bos taurus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 ILE O 117
MET O 130
ARG O 320
 None
 0.87A 4lnwA-4o59O:
undetectable		 4lnwA-4o59O:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Mesorhizobium
japonicum) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 ILE A  84
MET A 133
ARG A 132
 None
 0.87A 4lnwA-4om8A:
undetectable		 4lnwA-4om8A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otp SERINE/THREONINE-PRO
TEIN KINASE RIO1

(Homo sapiens) 		PF01163
(RIO1) 		3 ILE A 268
MET A 173
ARG A 176
 None
 0.88A 4lnwA-4otpA:
undetectable		 4lnwA-4otpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		3 ILE A 428
MET A 500
ARG A 503
 None
 0.95A 4lnwA-4ox2A:
undetectable		 4lnwA-4ox2A:
18.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ozt ECDYSONE RECEPTOR

(Pediculus
humanus) 		PF00104
(Hormone_recep) 		3 ILE E 331
MET E 372
ARG E 375
 P1A  E 601 (-4.4A)
P1A  E 601 (-4.0A)
P1A  E 601 (-3.9A)
 0.94A 4lnwA-4oztE:
25.3		 4lnwA-4oztE:
33.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		3 ILE A 939
MET A 865
ARG A 867
 None
 0.91A 4lnwA-4p7hA:
undetectable		 4lnwA-4p7hA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r29 UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		no annotation 3 ILE A 165
MET A 109
ARG A 160
 None
 0.95A 4lnwA-4r29A:
undetectable		 4lnwA-4r29A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wny UNIVERSAL STRESS
PROTEIN

(Burkholderia
pseudomallei) 		PF00582
(Usp) 		3 ILE A   5
MET A  75
ARG A  74
 None
 0.87A 4lnwA-4wnyA:
undetectable		 4lnwA-4wnyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi8 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella
clarridgeiae) 		PF02661
(Fic) 		3 ILE A 140
MET A 181
ARG A 180
 None
 0.85A 4lnwA-4xi8A:
undetectable		 4lnwA-4xi8A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkj CRISPR-ASSOCIATED
PROTEIN CAS1

(Streptococcus
pyogenes) 		PF01867
(Cas_Cas1) 		3 ILE A 265
MET A 187
ARG A 190
 None
 0.91A 4lnwA-4zkjA:
undetectable		 4lnwA-4zkjA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE

(Toxoplasma
gondii) 		PF00202
(Aminotran_3) 		3 ILE A 398
MET A 408
ARG A 409
 None
 0.80A 4lnwA-4zlvA:
undetectable		 4lnwA-4zlvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		3 ILE A 764
MET A 706
ARG A 705
 None
 0.82A 4lnwA-4zm6A:
undetectable		 4lnwA-4zm6A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn1 TRANSCRIPTION
ELONGATION FACTOR
SPT5

(Methanocaldococcus
jannaschii) 		PF00467
(KOW)
PF03439
(Spt5-NGN) 		3 ILE A  66
MET A  19
ARG A  22
 None
 0.86A 4lnwA-4zn1A:
undetectable		 4lnwA-4zn1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		3 ILE A  81
MET A 153
ARG A 156
 None
B12  A1101 ( 3.7A)
None
 0.76A 4lnwA-5cjuA:
undetectable		 4lnwA-5cjuA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23

(Homo sapiens) 		PF03097
(BRO1) 		3 ILE A 206
MET A 140
ARG A 134
 None
 0.76A 4lnwA-5crvA:
undetectable		 4lnwA-5crvA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		3 ILE A 271
MET A 221
ARG A 224
 None
 0.69A 4lnwA-5dztA:
undetectable		 4lnwA-5dztA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		3 ILE A 394
MET A 176
ARG A 399
 None
 0.92A 4lnwA-5ek8A:
undetectable		 4lnwA-5ek8A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		3 ILE A 144
MET A 156
ARG A 155
 None
5U5  A 401 (-4.8A)
None
 0.86A 4lnwA-5eykA:
undetectable		 4lnwA-5eykA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT SKI6

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 ILE B 161
MET B 228
ARG B 225
 None
 0.91A 4lnwA-5g06B:
undetectable		 4lnwA-5g06B:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 3 ILE C 421
MET C 303
ARG C 308
 None
 0.94A 4lnwA-5hr4C:
undetectable		 4lnwA-5hr4C:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in8 ARISTOLOCHENE
SYNTHASE

(Aspergillus
terreus) 		no annotation 3 ILE A 140
MET A 148
ARG A 149
 None
None
GOL  A 401 (-3.1A)
 0.93A 4lnwA-5in8A:
undetectable		 4lnwA-5in8A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mea CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		no annotation 3 ILE A 360
MET A 351
ARG A 353
 None
 0.69A 4lnwA-5meaA:
undetectable		 4lnwA-5meaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A

(Methanothermococcus
thermolithotrophicus) 		PF00374
(NiFeSe_Hases) 		3 ILE F 379
MET F 227
ARG F 294
 None
 0.80A 4lnwA-5odrF:
undetectable		 4lnwA-5odrF:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2

(Homo sapiens) 		no annotation 3 ILE B  50
MET B 253
ARG B 254
 None
 0.86A 4lnwA-5ofbB:
undetectable		 4lnwA-5ofbB:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Mycolicibacterium
smegmatis) 		no annotation 3 ILE A 117
MET A 108
ARG A 112
 None
 0.87A 4lnwA-5ovkA:
undetectable		 4lnwA-5ovkA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui3 DIHYDRODIPICOLINATE
SYNTHASE

(Chlamydomonas
reinhardtii) 		no annotation 3 ILE D 221
MET D 236
ARG D  27
 None
 0.77A 4lnwA-5ui3D:
undetectable		 4lnwA-5ui3D:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwz ALDEHYDE
DECARBONYLASE

(Gloeobacter
violaceus) 		no annotation 3 ILE A 114
MET A 224
ARG A 227
 None
 0.89A 4lnwA-5uwzA:
undetectable		 4lnwA-5uwzA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		3 ILE A 114
MET A 297
ARG A 298
 None
 0.82A 4lnwA-5vwmA:
undetectable		 4lnwA-5vwmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w88 TROPONIN C, TROPONIN
I

(Homo sapiens) 		PF00992
(Troponin)
PF13833
(EF-hand_8) 		3 ILE A  36
MET A  45
ARG A  46
 9XG  A 201 ( 3.3A)
9XG  A 201 (-2.4A)
None
 0.91A 4lnwA-5w88A:
undetectable		 4lnwA-5w88A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w88 TROPONIN C, TROPONIN
I

(Homo sapiens) 		PF00992
(Troponin)
PF13833
(EF-hand_8) 		3 ILE A  61
MET A  45
ARG A  46
 9XG  A 201 ( 4.0A)
9XG  A 201 (-2.4A)
None
 0.79A 4lnwA-5w88A:
undetectable		 4lnwA-5w88A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN

(Pyrococcus
horikoshii) 		no annotation 3 ILE A  88
MET A 300
ARG A 105
 None
 0.81A 4lnwA-5x09A:
undetectable		 4lnwA-5x09A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 3 ILE A 394
MET A 405
ARG A 406
 None
 0.93A 4lnwA-6c7sA:
undetectable		 4lnwA-6c7sA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Acropora
millepora) 		no annotation 3 ILE A 118
MET A 131
ARG A 322
 None
 0.88A 4lnwA-6dfzA:
undetectable		 4lnwA-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 3 ILE A1943
MET A1953
ARG A1940
 None
None
NAG  A3016 (-3.4A)
 0.90A 4lnwA-6fb3A:
undetectable		 4lnwA-6fb3A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-) 		no annotation 3 ILE A 170
MET A 179
ARG A 176
 None
 0.80A 4lnwA-6ft5A:
undetectable		 4lnwA-6ft5A:
undetectable