SIMILAR PATTERNS OF AMINO ACIDS FOR 4LMN_A_EUIA503_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)


(Escherichia
coli)
PF00117
(GATase)
PF00988
(CPSase_sm_chain)
3 ASP B1584
VAL B1581
ASN B1562
None
0.79A 4lmnA-1a9xB:
0.0
4lmnA-1a9xB:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1e CATALYTIC ANTIBODY
1E9 (HEAVY CHAIN)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 ASP H 183
VAL H 177
ASN H  84
None
0.76A 4lmnA-1c1eH:
0.0
4lmnA-1c1eH:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE


(Geobacillus
stearothermophilus)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C)
3 ASP A  24
VAL A  18
ASN A  29
CA  A 682 (-3.2A)
None
CA  A 682 (-3.1A)
0.72A 4lmnA-1cygA:
0.0
4lmnA-1cygA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2o COLLAGEN ADHESIN

(Staphylococcus
aureus)
PF05738
(Cna_B)
3 ASP A 709
VAL A 705
ASN A 562
None
0.66A 4lmnA-1d2oA:
0.0
4lmnA-1d2oA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2p COLLAGEN ADHESIN

(Staphylococcus
aureus)
PF05738
(Cna_B)
3 ASP A 709
VAL A 705
ASN A 562
None
0.66A 4lmnA-1d2pA:
0.0
4lmnA-1d2pA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2p COLLAGEN ADHESIN

(Staphylococcus
aureus)
PF05738
(Cna_B)
3 ASP A 896
VAL A 892
ASN A 749
None
0.66A 4lmnA-1d2pA:
0.0
4lmnA-1d2pA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbj IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 ASP H 183
VAL H 177
ASN H  84
None
0.75A 4lmnA-1dbjH:
0.0
4lmnA-1dbjH:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egz ENDOGLUCANASE Z

(Dickeya
chrysanthemi)
PF00150
(Cellulase)
3 ASP A 180
VAL A 174
ASN A 141
None
0.74A 4lmnA-1egzA:
0.0
4lmnA-1egzA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewr DNA MISMATCH REPAIR
PROTEIN MUTS


(Thermus
aquaticus)
PF00488
(MutS_V)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III)
3 ASP A 662
VAL A 579
ASN A 585
None
0.78A 4lmnA-1ewrA:
0.0
4lmnA-1ewrA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8y NUCLEOSIDE
2-DEOXYRIBOSYLTRANSF
ERASE


(Lactobacillus
leichmannii)
PF05014
(Nuc_deoxyrib_tr)
3 ASP A  80
VAL A 109
ASN A 145
None
0.79A 4lmnA-1f8yA:
0.0
4lmnA-1f8yA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli)
PF00149
(Metallophos)
PF02872
(5_nucleotid_C)
3 ASP A  41
VAL A  89
ASN A 116
ZN  A 600 (-3.1A)
None
CO3  A 602 ( 2.6A)
0.69A 4lmnA-1hp1A:
undetectable
4lmnA-1hp1A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
3 ASP A 372
VAL A 388
ASN A 611
None
0.81A 4lmnA-1kcwA:
undetectable
4lmnA-1kcwA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
3 ASP A 494
VAL A 552
ASN A 585
None
0.71A 4lmnA-1ksiA:
1.0
4lmnA-1ksiA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9g CONSERVED
HYPOTHETICAL PROTEIN


(Thermotoga
maritima)
PF03167
(UDG)
3 ASP A 119
VAL A 122
ASN A 117
None
0.69A 4lmnA-1l9gA:
undetectable
4lmnA-1l9gA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ly1 POLYNUCLEOTIDE
KINASE


(Escherichia
virus T4)
PF13671
(AAA_33)
3 ASP A  85
VAL A 111
ASN A  31
SO4  A 602 (-4.3A)
None
None
0.48A 4lmnA-1ly1A:
undetectable
4lmnA-1ly1A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
3 ASP A 155
VAL A 124
ASN A 128
None
0.80A 4lmnA-1moxA:
undetectable
4lmnA-1moxA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ


(Pseudomonas
aeruginosa)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
3 ASP A 300
VAL A 309
ASN A  34
None
0.80A 4lmnA-1ofuA:
undetectable
4lmnA-1ofuA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrc POLYNUCLEOTIDE
KINASE


(Escherichia
virus T4)
PF13671
(AAA_33)
3 ASP A  85
VAL A 111
ASN A  31
None
0.58A 4lmnA-1rrcA:
undetectable
4lmnA-1rrcA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1


(Homo sapiens)
PF00685
(Sulfotransfer_1)
3 ASP A 244
VAL A 241
ASN A 391
None
0.78A 4lmnA-1t8tA:
undetectable
4lmnA-1t8tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tx9 SCAFFOLDING PROTEIN
D


(Escherichia
virus phiX174)
PF02925
(gpD)
3 ASP A  35
VAL A  86
ASN A 141
None
0.78A 4lmnA-1tx9A:
undetectable
4lmnA-1tx9A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47)
PF00544
(Pec_lyase_C)
3 ASP A 333
VAL A 359
ASN A 281
None
0.68A 4lmnA-1vblA:
undetectable
4lmnA-1vblA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE


(Clostridium
acetobutylicum)
PF04029
(2-ph_phosp)
3 ASP A  26
VAL A 123
ASN A  83
MG  A 400 (-3.1A)
None
3SL  A 300 (-3.8A)
0.80A 4lmnA-1vr0A:
undetectable
4lmnA-1vr0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE


(Thermoproteus
tenax)
PF00121
(TIM)
PF05690
(ThiG)
3 ASP A 116
VAL A 138
ASN A  38
None
0.58A 4lmnA-1w0mA:
undetectable
4lmnA-1w0mA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wod MODA

(Escherichia
coli)
PF13531
(SBP_bac_11)
3 ASP A 173
VAL A 183
ASN A  83
None
0.67A 4lmnA-1wodA:
undetectable
4lmnA-1wodA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
3 ASP A 265
VAL A 252
ASN A 270
None
0.79A 4lmnA-1wy2A:
undetectable
4lmnA-1wy2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495


(Pyrococcus
horikoshii)
PF05161
(MOFRL)
PF13660
(DUF4147)
3 ASP A  22
VAL A  14
ASN A  29
None
EDO  A 501 ( 4.9A)
None
0.81A 4lmnA-1x3lA:
1.4
4lmnA-1x3lA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycg NITRIC OXIDE
REDUCTASE


(Moorella
thermoacetica)
PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B)
3 ASP A  85
VAL A  17
ASN A 166
FEO  A 501 ( 2.4A)
None
None
0.81A 4lmnA-1ycgA:
undetectable
4lmnA-1ycgA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT


(Methanocaldococcus
jannaschii)
PF01420
(Methylase_S)
3 ASP A 265
VAL A 313
ASN A 321
None
0.73A 4lmnA-1yf2A:
undetectable
4lmnA-1yf2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae)
PF01593
(Amino_oxidase)
3 ASP A 287
VAL A 460
ASN A 259
None
0.81A 4lmnA-1yy5A:
undetectable
4lmnA-1yy5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR


(Sus scrofa)
PF13516
(LRR_6)
3 ASP A  31
VAL A  27
ASN A  61
None
0.78A 4lmnA-2bnhA:
undetectable
4lmnA-2bnhA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0g WINDBEUTEL PROTEIN

(Drosophila
melanogaster)
PF07749
(ERp29)
PF07912
(ERp29_N)
3 ASP A1029
VAL A1046
ASN A1091
None
0.70A 4lmnA-2c0gA:
undetectable
4lmnA-2c0gA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwu GLUTAMATE RACEMASE

(Bacillus
anthracis)
PF01177
(Asp_Glu_race)
3 ASP A  14
VAL A  62
ASN A  41
DGL  A 278 (-3.6A)
None
None
0.54A 4lmnA-2dwuA:
undetectable
4lmnA-2dwuA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fin RABBITPOX ENCODED CC
CHEMOKINE INHIBITOR


(Vaccinia virus)
PF02250
(Orthopox_35kD)
3 ASP A 201
VAL A 211
ASN A 168
None
0.75A 4lmnA-2finA:
undetectable
4lmnA-2finA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
3 ASP A 322
VAL A 325
ASN A 347
None
0.71A 4lmnA-2gpvA:
undetectable
4lmnA-2gpvA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT


(Thermus
thermophilus)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD)
3 ASP A 416
VAL A 420
ASN A 676
None
0.67A 4lmnA-2ipcA:
undetectable
4lmnA-2ipcA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE


(Neurospora
crassa)
PF05183
(RdRP)
3 ASP A 452
VAL A 420
ASN A 474
None
0.78A 4lmnA-2j7nA:
undetectable
4lmnA-2j7nA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpu RBP1

(Hordeum vulgare)
PF00076
(RRM_1)
3 ASP A  21
VAL A  55
ASN A  42
None
0.78A 4lmnA-2mpuA:
undetectable
4lmnA-2mpuA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p17 PIRIN-LIKE PROTEIN

(Geobacillus
kaustophilus)
PF02678
(Pirin)
PF05726
(Pirin_C)
3 ASP A 136
VAL A 149
ASN A 131
None
0.73A 4lmnA-2p17A:
undetectable
4lmnA-2p17A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2c CASPASE-2

(Homo sapiens)
PF00656
(Peptidase_C14)
PF12796
(Ank_2)
PF13637
(Ank_4)
3 ASP P  44
VAL B 246
ASN P  78
None
0.64A 4lmnA-2p2cP:
undetectable
4lmnA-2p2cP:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)


(Geobacillus
stearothermophilus)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
3 ASP A 193
VAL A  97
ASN A 229
None
0.81A 4lmnA-2pjrA:
undetectable
4lmnA-2pjrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9t DING

(Pseudomonas
fluorescens)
PF12849
(PBP_like_2)
3 ASP A 220
VAL A 106
ASN A 245
None
0.64A 4lmnA-2q9tA:
undetectable
4lmnA-2q9tA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis)
no annotation 3 ASP A  89
VAL A  23
ASN A 170
FEO  A 701 ( 2.4A)
None
None
0.78A 4lmnA-2q9uA:
undetectable
4lmnA-2q9uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis)
PF00480
(ROK)
3 ASP A 114
VAL A 143
ASN A  88
None
0.68A 4lmnA-2qm1A:
undetectable
4lmnA-2qm1A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ver AFIMBRIAL ADHESIN
AFA-III


(Escherichia
coli)
PF04619
(Adhesin_Dr)
3 ASP A  80
VAL A  40
ASN A 125
None
0.77A 4lmnA-2verA:
undetectable
4lmnA-2verA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsk HEMAGGLUTININ-NEURAM
INIDASE


(Hendra
henipavirus)
PF00423
(HN)
3 ASP A 585
VAL A 215
ASN A 557
None
0.66A 4lmnA-2vskA:
undetectable
4lmnA-2vskA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wt8 MICROCEPHALIN

(Homo sapiens)
PF12738
(PTCB-BRCT)
3 ASP A  54
VAL A  13
ASN A  95
None
0.78A 4lmnA-2wt8A:
undetectable
4lmnA-2wt8A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris)
PF13432
(TPR_16)
PF13844
(Glyco_transf_41)
3 ASP A 459
VAL A 513
ASN A 496
None
0.49A 4lmnA-2xgoA:
undetectable
4lmnA-2xgoA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt4 MCBG-LIKE PROTEIN

(Xanthomonas
albilineans)
PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4)
3 ASP A 146
VAL A 123
ASN A 108
None
0.78A 4lmnA-2xt4A:
undetectable
4lmnA-2xt4A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE


(Pseudomonas sp.
P-501)
no annotation 3 ASP A  96
VAL A 374
ASN A 611
GOL  A 902 (-4.0A)
FAD  A 801 ( 4.1A)
GOL  A 902 ( 3.8A)
0.79A 4lmnA-2yr5A:
undetectable
4lmnA-2yr5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yt4 PROTEIN DGCR8

(Homo sapiens)
PF00035
(dsrm)
3 ASP A 579
VAL A 504
ASN A 599
None
0.77A 4lmnA-2yt4A:
undetectable
4lmnA-2yt4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE


(Aquifex
aeolicus)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
3 ASP A 125
VAL A 183
ASN A 171
None
0.79A 4lmnA-2yw2A:
2.5
4lmnA-2yw2A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE


(Pseudomonas sp.
ATCC 19121)
PF00155
(Aminotran_1_2)
3 ASP A 263
VAL A 438
ASN A 229
None
0.59A 4lmnA-2zy2A:
undetectable
4lmnA-2zy2A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N


(Rhodobacter
capsulatus)
PF00148
(Oxidored_nitro)
3 ASP A 366
VAL A 369
ASN A 364
None
0.68A 4lmnA-3aeuA:
undetectable
4lmnA-3aeuA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)


(Rattus
norvegicus)
PF00300
(His_Phos_1)
PF01591
(6PF2K)
3 ASP A 128
VAL A 124
ASN A 131
None
0.74A 4lmnA-3bifA:
undetectable
4lmnA-3bifA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE


(Thermoanaerobacterium
thermosulfurigenes)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
3 ASP A  27
VAL A  21
ASN A  32
CA  A 699 (-3.1A)
None
CA  A 699 (-3.0A)
0.73A 4lmnA-3bmwA:
undetectable
4lmnA-3bmwA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8p UNCHARACTERIZED
PROTEIN


(Shewanella
oneidensis)
PF03061
(4HBT)
3 ASP A  28
VAL A  80
ASN A  35
None
0.71A 4lmnA-3e8pA:
undetectable
4lmnA-3e8pA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8p UNCHARACTERIZED
PROTEIN


(Shewanella
oneidensis)
PF03061
(4HBT)
3 ASP A  40
VAL A  80
ASN A  35
None
0.78A 4lmnA-3e8pA:
undetectable
4lmnA-3e8pA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Streptococcus
pneumoniae)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
3 ASP A 253
VAL A 275
ASN A 177
None
0.71A 4lmnA-3ecqA:
undetectable
4lmnA-3ecqA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3o VACUOLAR TRANSPORTER
CHAPERONE 2


(Saccharomyces
cerevisiae)
PF09359
(VTC)
3 ASP A 441
VAL A 399
ASN A 349
None
0.80A 4lmnA-3g3oA:
1.9
4lmnA-3g3oA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg PERMEASE
MOLYBDATE-BINDING
PERIPLASMIC PROTEIN


(Xanthomonas
citri)
PF13531
(SBP_bac_11)
3 ASP A 173
VAL A 183
ASN A  83
None
0.70A 4lmnA-3gzgA:
undetectable
4lmnA-3gzgA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE


(Yersinia pestis)
PF00709
(Adenylsucc_synt)
3 ASP A 421
VAL A  20
ASN A  47
None
0.78A 4lmnA-3hidA:
undetectable
4lmnA-3hidA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inn PANTOTHENATE
SYNTHETASE


(Brucella
melitensis)
PF02569
(Pantoate_ligase)
3 ASP A 150
VAL A 171
ASN A 277
ATP  A 300 (-3.6A)
None
None
0.77A 4lmnA-3innA:
undetectable
4lmnA-3innA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyn QUINONE
OXIDOREDUCTASE


(Pseudomonas
syringae group
genomosp. 3)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 ASP A 215
VAL A 128
ASN A 240
None
0.73A 4lmnA-3jynA:
undetectable
4lmnA-3jynA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfo NUCLEOPORIN NUP133

(Saccharomyces
cerevisiae)
no annotation 3 ASP A 952
VAL A 997
ASN A1027
None
0.67A 4lmnA-3kfoA:
undetectable
4lmnA-3kfoA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgb THYMIDYLATE SYNTHASE
1/2


(Encephalitozoon
cuniculi)
PF00303
(Thymidylat_synt)
3 ASP A 197
VAL A  37
ASN A 205
None
0.80A 4lmnA-3kgbA:
undetectable
4lmnA-3kgbA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens)
PF00291
(PALP)
3 ASP A 132
VAL A 138
ASN A 154
None
None
LLP  A  56 ( 4.7A)
0.81A 4lmnA-3l6rA:
undetectable
4lmnA-3l6rA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mix FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA


(Bacillus
subtilis)
PF00771
(FHIPEP)
3 ASP A 327
VAL A 336
ASN A 391
None
0.80A 4lmnA-3mixA:
undetectable
4lmnA-3mixA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml3 OUTER MEMBRANE
PROTEIN ICSA
AUTOTRANSPORTER


(Shigella
flexneri)
PF03212
(Pertactin)
3 ASP A 662
VAL A 636
ASN A 626
None
0.76A 4lmnA-3ml3A:
undetectable
4lmnA-3ml3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1


(Bos taurus)
PF00481
(PP2C)
3 ASP A 242
VAL A 251
ASN A 217
None
0.81A 4lmnA-3mq3A:
undetectable
4lmnA-3mq3A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5b LOW DENSITY
LIPOPROTEIN RECEPTOR
VARIANT


(Homo sapiens)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition)
3 ASP L 461
VAL L 415
ASN L 644
None
0.70A 4lmnA-3p5bL:
undetectable
4lmnA-3p5bL:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A


(Aquifex
aeolicus)
PF00398
(RrnaAD)
3 ASP B  83
VAL B  79
ASN B 113
None
0.80A 4lmnA-3r9xB:
undetectable
4lmnA-3r9xB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE


(Thermus
thermophilus)
PF07521
(RMMBL)
PF12706
(Lactamase_B_2)
3 ASP A 204
VAL A 168
ASN A  24
None
None
ZN  A 600 ( 4.7A)
0.73A 4lmnA-3t3oA:
undetectable
4lmnA-3t3oA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfm MYOSIN X

(Rattus
norvegicus)
PF00169
(PH)
3 ASP A 113
VAL A  96
ASN A  55
None
0.80A 4lmnA-3tfmA:
undetectable
4lmnA-3tfmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr9 DIHYDROPTEROATE
SYNTHASE


(Coxiella
burnetii)
PF00809
(Pterin_bind)
3 ASP A  67
VAL A  59
ASN A  35
None
None
CL  A 315 (-3.6A)
0.62A 4lmnA-3tr9A:
undetectable
4lmnA-3tr9A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo)
PF00082
(Peptidase_S8)
3 ASP A 427
VAL A 335
ASN A 519
None
0.81A 4lmnA-3vtaA:
undetectable
4lmnA-3vtaA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9v PHOSPHATE-BINDING
PROTEIN


(unidentified
prokaryotic
organism)
PF12849
(PBP_like_2)
3 ASP A 224
VAL A 105
ASN A 251
None
0.68A 4lmnA-3w9vA:
undetectable
4lmnA-3w9vA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea)
no annotation 3 ASP A  51
VAL A  47
ASN A 651
EDO  A 807 (-4.8A)
None
None
0.81A 4lmnA-3wevA:
undetectable
4lmnA-3wevA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis)
PF00753
(Lactamase_B)
PF07521
(RMMBL)
3 ASP A 195
VAL A 160
ASN A  23
None
None
ZN  A1556 ( 4.7A)
0.76A 4lmnA-3zq4A:
undetectable
4lmnA-3zq4A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A


(Mycobacterium
tuberculosis)
PF00005
(ABC_tran)
3 ASP A 912
VAL A 652
ASN A 889
None
0.78A 4lmnA-3zqjA:
undetectable
4lmnA-3zqjA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq1 SBSB PROTEIN

(Geobacillus
stearothermophilus)
no annotation 3 ASP C 705
VAL C 692
ASN C 905
None
0.79A 4lmnA-4aq1C:
undetectable
4lmnA-4aq1C:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN


(Homo sapiens)
PF00450
(Peptidase_S10)
3 ASP B 380
VAL B 413
ASN B 376
None
0.80A 4lmnA-4az3B:
undetectable
4lmnA-4az3B:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2


(Homo sapiens)
PF02854
(MIF4G)
3 ASP A 265
VAL A 308
ASN A 258
None
0.79A 4lmnA-4cemA:
undetectable
4lmnA-4cemA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN


(Bacteroides
vulgatus)
PF12741
(SusD-like)
3 ASP A  89
VAL A 100
ASN A  77
None
0.81A 4lmnA-4f7aA:
undetectable
4lmnA-4f7aA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE


(Burkholderia
thailandensis)
PF00171
(Aldedh)
3 ASP A 348
VAL A 234
ASN A 340
None
0.81A 4lmnA-4ghkA:
undetectable
4lmnA-4ghkA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN


(Escherichia
coli)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 ASP C 393
VAL C 399
ASN C 128
None
0.79A 4lmnA-4gypC:
undetectable
4lmnA-4gypC:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana)
PF03098
(An_peroxidase)
3 ASP A 576
VAL A 309
ASN A  98
None
0.57A 4lmnA-4hhrA:
undetectable
4lmnA-4hhrA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu0 CELLULASE

(uncultured
bacterium)
PF00150
(Cellulase)
3 ASP A 144
VAL A 185
ASN A  77
None
0.79A 4lmnA-4hu0A:
undetectable
4lmnA-4hu0A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE


(Paenibacillus
macerans)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
3 ASP A  27
VAL A  21
ASN A  32
CA  A 701 (-3.1A)
EDO  A 718 ( 3.9A)
CA  A 701 (-3.2A)
0.72A 4lmnA-4jclA:
undetectable
4lmnA-4jclA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 ASP A 351
VAL A 117
ASN A 140
None
None
CL  A 411 (-3.2A)
0.80A 4lmnA-4jn7A:
undetectable
4lmnA-4jn7A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1


(Physcomitrella
patens)
PF01156
(IU_nuc_hydro)
3 ASP A  29
VAL A 263
ASN A 184
CA  A 400 ( 4.5A)
None
CA  A 400 ( 4.2A)
0.78A 4lmnA-4kpnA:
undetectable
4lmnA-4kpnA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE


(Burkholderia
cenocepacia)
PF00171
(Aldedh)
3 ASP A 235
VAL A 161
ASN A  60
None
0.76A 4lmnA-4lihA:
undetectable
4lmnA-4lihA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lik DNA PRIMASE SMALL
SUBUNIT


(Homo sapiens)
PF01896
(DNA_primase_S)
3 ASP A 232
VAL A 118
ASN A 236
None
0.62A 4lmnA-4likA:
0.6
4lmnA-4likA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn6 SENSOR PROTEIN
KINASE WALK


(Staphylococcus
aureus)
PF13426
(PAS_9)
3 ASP A 274
VAL A 288
ASN A 345
ZN  A 401 (-2.1A)
None
None
0.61A 4lmnA-4mn6A:
undetectable
4lmnA-4mn6A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE


(Pseudomonas
aeruginosa)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
3 ASP A 207
VAL A 186
ASN A 212
None
0.72A 4lmnA-4mrqA:
2.2
4lmnA-4mrqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN


(Homo sapiens)
PF00450
(Peptidase_S10)
3 ASP A 380
VAL A 413
ASN A 376
ASP  A 380 ( 0.5A)
VAL  A 413 ( 0.6A)
ASN  A 376 ( 0.6A)
0.76A 4lmnA-4mwtA:
undetectable
4lmnA-4mwtA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ


(Pseudomonas
putida)
PF16822
(ALGX)
3 ASP A 190
VAL A 185
ASN A 292
None
0.79A 4lmnA-4o8vA:
undetectable
4lmnA-4o8vA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ops MAJOR CAPSID PROTEIN

(Norwalk virus)
PF08435
(Calici_coat_C)
3 ASP A 450
VAL A 404
ASN A 239
None
0.79A 4lmnA-4opsA:
undetectable
4lmnA-4opsA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1z PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron)
PF16215
(DUF4876)
3 ASP A 238
VAL A 242
ASN A 227
UNX  A 401 ( 3.0A)
None
None
0.68A 4lmnA-4q1zA:
undetectable
4lmnA-4q1zA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''


(Thermococcus
kodakarensis)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
3 ASP A 851
VAL A 854
ASN C 364
None
0.65A 4lmnA-4qiwA:
undetectable
4lmnA-4qiwA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqr 3,5-EPIMERASE/4-REDU
CTASE


(Arabidopsis
thaliana)
PF04321
(RmlD_sub_bind)
3 ASP A  99
VAL A  91
ASN A 160
None
0.77A 4lmnA-4qqrA:
undetectable
4lmnA-4qqrA:
21.59