SIMILAR PATTERNS OF AMINO ACIDS FOR 4LL3_A_017A201_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b74 | GLUTAMATE RACEMASE (Aquifexpyrophilus) |
PF01177(Asp_Glu_race) | 4 | VAL A 92GLY A 113VAL A 97ILE A 93 | None | 0.74A | 4ll3A-1b74A:undetectable | 4ll3A-1b74A:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b7g | PROTEIN(GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE) (Sulfolobussolfataricus) |
PF01113(DapB_N)PF02800(Gp_dh_C) | 5 | ALA O 43VAL O 31GLY O 10VAL O 52ILE O 50 | NoneNoneSO4 O 610 ( 3.8A)NoneNone | 1.26A | 4ll3A-1b7gO:0.0 | 4ll3A-1b7gO:15.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1brr | PROTEIN(BACTERIORHODOPSIN) (Halobacteriumsalinarum) |
PF01036(Bac_rhodopsin) | 5 | ALA A 126VAL A 69GLY A 195PRO A 77ILE A 78 | None | 1.33A | 4ll3A-1brrA:0.0 | 4ll3A-1brrA:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cdo | ALCOHOLDEHYDROGENASE (Gadus morhua) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 71VAL A 170PRO A 329VAL A 328ILE A 91 | None | 1.29A | 4ll3A-1cdoA:undetectable | 4ll3A-1cdoA:13.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cu1 | PROTEIN(PROTEASE/HELICASENS3) (Hepacivirus C) |
PF02907(Peptidase_S29)PF07652(Flavi_DEAD) | 4 | ALA A 315ASP A 285GLY A 281ILE A 287 | None | 0.74A | 4ll3A-1cu1A:1.3 | 4ll3A-1cu1A:9.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d4e | FLAVOCYTOCHROME CFUMARATE REDUCTASE (Shewanellaoneidensis) |
PF00890(FAD_binding_2)PF14537(Cytochrom_c3_2) | 4 | ALA A 167GLY A 161VAL A 554ILE A 550 | FAD A 600 (-3.7A)NoneNoneFAD A 600 (-4.3A) | 0.76A | 4ll3A-1d4eA:undetectable | 4ll3A-1d4eA:8.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d4e | FLAVOCYTOCHROME CFUMARATE REDUCTASE (Shewanellaoneidensis) |
PF00890(FAD_binding_2)PF14537(Cytochrom_c3_2) | 4 | ALA A 167GLY A 162VAL A 554ILE A 550 | FAD A 600 (-3.7A)FAD A 600 (-3.2A)NoneFAD A 600 (-4.3A) | 0.75A | 4ll3A-1d4eA:undetectable | 4ll3A-1d4eA:8.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1di0 | LUMAZINE SYNTHASE (Brucellaabortus) |
PF00885(DMRL_synthase) | 5 | ALA A 143VAL A 76GLY A 136VAL A 48ILE A 15 | None | 1.45A | 4ll3A-1di0A:0.0 | 4ll3A-1di0A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dms | DMSO REDUCTASE (Rhodobactercapsulatus) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 5 | ASP A 731VAL A 689GLY A 699VAL A 736ILE A 696 | None | 1.44A | 4ll3A-1dmsA:1.8 | 4ll3A-1dmsA:10.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1efp | PROTEIN (ELECTRONTRANSFERFLAVOPROTEIN) (Paracoccusdenitrificans) |
PF01012(ETF) | 4 | ALA B 89VAL B 215VAL B 101ILE B 96 | NoneNoneAMP A 400 ( 4.7A)None | 0.68A | 4ll3A-1efpB:0.0 | 4ll3A-1efpB:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1efy | POLY (ADP-RIBOSE)POLYMERASE (Gallus gallus) |
PF00644(PARP)PF02877(PARP_reg) | 4 | VAL A 991GLY A 922VAL A 994ILE A 895 | None | 0.74A | 4ll3A-1efyA:undetectable | 4ll3A-1efyA:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eu1 | DIMETHYL SULFOXIDEREDUCTASE (Rhodobactersphaeroides) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 5 | ASP A 731VAL A 689GLY A 699VAL A 736ILE A 696 | None | 1.46A | 4ll3A-1eu1A:1.5 | 4ll3A-1eu1A:9.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g0d | PROTEIN-GLUTAMINEGAMMA-GLUTAMYLTRANSFERASE (Pagrus major) |
PF00868(Transglut_N)PF00927(Transglut_C)PF01841(Transglut_core) | 5 | VAL A 390GLY A 382PRO A 372VAL A 373ILE A 376 | None | 1.36A | 4ll3A-1g0dA:undetectable | 4ll3A-1g0dA:9.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gq2 | MALIC ENZYME (Columba livia) |
PF00390(malic)PF03949(Malic_M) | 5 | ALA A 289VAL A 470GLY A 465VAL A 522ILE A 498 | None | 1.30A | 4ll3A-1gq2A:undetectable | 4ll3A-1gq2A:10.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gv0 | MALATE DEHYDROGENASE (Chlorobaculumtepidum) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | VAL A 73GLY A 103VAL A 116ILE A 114 | None | 0.69A | 4ll3A-1gv0A:undetectable | 4ll3A-1gv0A:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hn0 | CHONDROITIN ABCLYASE I (Proteusvulgaris) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF09092(Lyase_N)PF09093(Lyase_catalyt) | 5 | ALA A 736GLY A 631PRO A1012VAL A 958ILE A 943 | None | 1.24A | 4ll3A-1hn0A:undetectable | 4ll3A-1hn0A:9.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 29GLY A 48ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 (-2.8A)A79 A 800 (-3.6A)A79 A 800 (-3.6A) | 1.41A | 4ll3A-1hvcA:14.0 | 4ll3A-1hvcA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 29GLY A 48ILE A 84 | A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 (-2.7A)A79 A 800 (-4.1A)A79 A 800 (-3.8A) | 1.43A | 4ll3A-1hvcA:14.0 | 4ll3A-1hvcA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 29GLY A 49ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 (-2.8A)A79 A 800 ( 3.7A)A79 A 800 (-3.6A) | 1.01A | 4ll3A-1hvcA:14.0 | 4ll3A-1hvcA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 29GLY A 49ILE A 84 | A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 (-2.7A)A79 A 800 (-3.4A)A79 A 800 (-3.8A) | 0.99A | 4ll3A-1hvcA:14.0 | 4ll3A-1hvcA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25ALA A 28ASP A 30VAL A 32GLY A 49PRO A 81VAL A 82ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 ( 4.9A)A79 A 800 ( 4.4A)A79 A 800 ( 3.7A)A79 A 800 ( 3.9A)A79 A 800 (-4.5A)A79 A 800 (-3.6A) | 0.59A | 4ll3A-1hvcA:14.0 | 4ll3A-1hvcA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25ALA A 28ASP A 30VAL A 32GLY A 49PRO A 81VAL A 82ILE A 84 | A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 ( 4.7A)A79 A 800 ( 4.3A)A79 A 800 (-3.4A)A79 A 800 ( 3.4A)A79 A 800 (-4.5A)A79 A 800 (-3.8A) | 0.42A | 4ll3A-1hvcA:14.0 | 4ll3A-1hvcA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28GLY A 48PRO A 81VAL A 82ILE A 84 | A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 (-4.1A)A79 A 800 ( 3.4A)A79 A 800 (-4.5A)A79 A 800 (-3.8A) | 0.90A | 4ll3A-1hvcA:14.0 | 4ll3A-1hvcA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28VAL A 32GLY A 48VAL A 82ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 ( 4.4A)A79 A 800 (-3.6A)A79 A 800 (-4.5A)A79 A 800 (-3.6A) | 0.98A | 4ll3A-1hvcA:14.0 | 4ll3A-1hvcA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | VAL A 32GLY A 51PRO A 81VAL A 82ILE A 84 | A79 A 800 ( 4.4A)NoneA79 A 800 ( 3.9A)A79 A 800 (-4.5A)A79 A 800 (-3.6A) | 1.07A | 4ll3A-1hvcA:14.0 | 4ll3A-1hvcA:98.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jjv | DEPHOSPHO-COA KINASE (Haemophilusinfluenzae) |
PF01121(CoaE) | 5 | ASP A 131VAL A 129GLY A 12PRO A 113VAL A 111 | NoneNoneATP A 300 (-3.5A)NoneNone | 1.40A | 4ll3A-1jjvA:undetectable | 4ll3A-1jjvA:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jkm | BREFELDIN A ESTERASE (Bacillussubtilis) |
PF07859(Abhydrolase_3) | 5 | ALA A 223ASP A 222GLY A 195VAL A 227ILE A 224 | None | 1.42A | 4ll3A-1jkmA:undetectable | 4ll3A-1jkmA:12.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jne | IMAGINAL DISC GROWTHFACTOR-2 (Drosophilamelanogaster) |
PF00704(Glyco_hydro_18) | 4 | ALA A 304VAL A 368GLY A 307ILE A 366 | None | 0.68A | 4ll3A-1jneA:undetectable | 4ll3A-1jneA:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kae | HISTIDINOLDEHYDROGENASE (Escherichiacoli) |
PF00815(Histidinol_dh) | 4 | ALA A 228ASP A 204GLY A 196ILE A 206 | None | 0.61A | 4ll3A-1kaeA:undetectable | 4ll3A-1kaeA:12.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lpf | DIHYDROLIPOAMIDEDEHYDROGENASE (Pseudomonasfluorescens) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ALA A 18VAL A 336GLY A 317VAL A 146ILE A 147 | NoneNoneFAD A 480 (-3.4A)NoneNone | 1.37A | 4ll3A-1lpfA:undetectable | 4ll3A-1lpfA:12.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o8u | 6-OXO CAMPHORHYDROLASE (Rhodococcuserythropolis) |
PF00378(ECH_1) | 5 | ALA A 203GLY A 209PRO A 110VAL A 111ILE A 112 | None | 1.50A | 4ll3A-1o8uA:undetectable | 4ll3A-1o8uA:15.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o94 | TRIMETHYLAMINEDEHYDROGENASE (Methylophilusmethylotrophus) |
PF00724(Oxidored_FMN)PF07992(Pyr_redox_2) | 5 | ALA A 405VAL A 392GLY A 688VAL A 395ILE A 394 | NoneNoneNoneADP A1731 (-4.7A)None | 1.42A | 4ll3A-1o94A:undetectable | 4ll3A-1o94A:9.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1on9 | METHYLMALONYL-COACARBOXYLTRANSFERASE12S SUBUNIT (Propionibacteriumfreudenreichii) |
PF01039(Carboxyl_trans) | 5 | ASP A 302VAL A 301GLY A 330VAL A 296ILE A 300 | None | 1.48A | 4ll3A-1on9A:undetectable | 4ll3A-1on9A:11.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1onl | GLYCINE CLEAVAGESYSTEM H PROTEIN (Thermusthermophilus) |
PF01597(GCV_H) | 4 | ALA A 31ASP A 29GLY A 36ILE A 27 | None | 0.76A | 4ll3A-1onlA:undetectable | 4ll3A-1onlA:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oqw | FIMBRIAL PROTEIN (Pseudomonasaeruginosa) |
PF00114(Pilin)PF07963(N_methyl) | 5 | ALA A 77ASP A 78GLY A 74VAL A 40ILE A 85 | None | 1.40A | 4ll3A-1oqwA:undetectable | 4ll3A-1oqwA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ovm | INDOLE-3-PYRUVATEDECARBOXYLASE (Enterobactercloacae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ASP A 382ALA A 437ASP A 435VAL A 459VAL A 431 | NoneTPP A 600 (-3.1A) MG A 601 ( 2.9A)NoneNone | 1.21A | 4ll3A-1ovmA:undetectable | 4ll3A-1ovmA:10.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pii | N-(5'PHOSPHORIBOSYL)ANTHRANILATEISOMERASE (Escherichiacoli) |
PF00218(IGPS)PF00697(PRAI) | 4 | VAL A 284GLY A 383PRO A 288ILE A 282 | None | 0.67A | 4ll3A-1piiA:undetectable | 4ll3A-1piiA:13.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pq5 | TRYPSIN (Fusariumoxysporum) |
PF00089(Trypsin) | 4 | ALA A 133GLY A 182VAL A 210ILE A 199 | NoneNoneARG A 703 (-4.5A)None | 0.74A | 4ll3A-1pq5A:undetectable | 4ll3A-1pq5A:15.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q7h | CONSERVEDHYPOTHETICAL PROTEIN (Thermoplasmaacidophilum) |
PF01472(PUA)PF09183(DUF1947) | 5 | ALA A 137VAL A 73GLY A 127VAL A 95ILE A 94 | None | 1.35A | 4ll3A-1q7hA:undetectable | 4ll3A-1q7hA:18.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 5 | ALA A 28ASP A 30VAL A 32PRO A 81ILE A 84 | None | 0.89A | 4ll3A-1q9pA:10.1 | 4ll3A-1q9pA:93.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 30VAL A 32ILE A 84 | None | 0.59A | 4ll3A-1q9pA:10.1 | 4ll3A-1q9pA:93.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r8g | HYPOTHETICAL PROTEINYBDK (Escherichiacoli) |
PF04107(GCS2) | 5 | ALA A 147ASP A 146GLY A 153VAL A 198ILE A 148 | None | 1.23A | 4ll3A-1r8gA:undetectable | 4ll3A-1r8gA:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1roe | FERREDOXIN (Synechococcuselongatus) |
PF00111(Fer2) | 5 | ALA A 80ASP A 58GLY A 73VAL A 28ILE A 25 | None | 1.37A | 4ll3A-1roeA:undetectable | 4ll3A-1roeA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ru3 | ACETYL-COA SYNTHASE (Carboxydothermushydrogenoformans) |
PF03598(CdhC) | 5 | ASP A 81GLY A 57PRO A 66VAL A 67ILE A 68 | NoneGOL A 962 (-3.1A)NoneNoneNone | 1.25A | 4ll3A-1ru3A:undetectable | 4ll3A-1ru3A:8.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rwr | FILAMENTOUSHEMAGGLUTININ (Bordetellapertussis) |
PF05860(Haemagg_act) | 4 | ALA A 73GLY A 96VAL A 21ILE A 23 | None | 0.75A | 4ll3A-1rwrA:undetectable | 4ll3A-1rwrA:16.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 29GLY A 49ILE A 84 | None | 0.99A | 4ll3A-1sivA:18.6 | 4ll3A-1sivA:50.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 30GLY A 49PRO A 81ILE A 84 | None | 0.44A | 4ll3A-1sivA:18.6 | 4ll3A-1sivA:50.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ASP A 25ALA A 28GLY A 48PRO A 81ILE A 84 | None | 0.85A | 4ll3A-1sivA:18.6 | 4ll3A-1sivA:50.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3h | DEPHOSPHO-COA KINASE (Escherichiacoli) |
PF01121(CoaE) | 5 | ASP A 131VAL A 129GLY A 12PRO A 113VAL A 111 | NoneNoneSO4 A 301 (-3.2A)NoneNone | 1.38A | 4ll3A-1t3hA:undetectable | 4ll3A-1t3hA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3h | DEPHOSPHO-COA KINASE (Escherichiacoli) |
PF01121(CoaE) | 5 | ASP A 185ASP A 131VAL A 130GLY A 177ILE A 173 | None | 1.22A | 4ll3A-1t3hA:undetectable | 4ll3A-1t3hA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3i | PROBABLE CYSTEINEDESULFURASE (Synechocystissp.) |
PF00266(Aminotran_5) | 5 | ALA A 340VAL A 185GLY A 331VAL A 176ILE A 178 | NoneNoneNonePLP A 600 (-4.9A)None | 1.43A | 4ll3A-1t3iA:undetectable | 4ll3A-1t3iA:13.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tg6 | PUTATIVEATP-DEPENDENT CLPPROTEASE PROTEOLYTICSUBUNIT (Homo sapiens) |
PF00574(CLP_protease) | 4 | ALA A 154VAL A 163GLY A 183ILE A 164 | None | 0.76A | 4ll3A-1tg6A:undetectable | 4ll3A-1tg6A:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1thm | THERMITASE (Thermoactinomycesvulgaris) |
PF00082(Peptidase_S8) | 4 | ALA A 96GLY A 91PRO A 229ILE A 34 | None | 0.69A | 4ll3A-1thmA:undetectable | 4ll3A-1thmA:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqy | ACTINORHODINPOLYKETIDE PUTATIVEBETA-KETOACYLSYNTHASE 2 (Streptomycescoelicolor) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ASP B 297ALA B 388VAL B 386GLY B 336VAL B 325 | None | 1.13A | 4ll3A-1tqyB:undetectable | 4ll3A-1tqyB:11.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqy | ACTINORHODINPOLYKETIDE PUTATIVEBETA-KETOACYLSYNTHASE 2 (Streptomycescoelicolor) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ASP B 297ALA B 388VAL B 386PRO B 326VAL B 325 | None | 1.42A | 4ll3A-1tqyB:undetectable | 4ll3A-1tqyB:11.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tt4 | PUTATIVE CYTOPLASMICPROTEIN (Salmonellaenterica) |
PF04107(GCS2) | 5 | ALA A 147ASP A 146GLY A 153VAL A 198ILE A 148 | None | 1.21A | 4ll3A-1tt4A:undetectable | 4ll3A-1tt4A:14.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tww | DHPS,DIHYDROPTEROATESYNTHASE (Bacillusanthracis) |
PF00809(Pterin_bind) | 5 | ALA A 265VAL A 253GLY A 239VAL A 258ILE A 22 | None | 1.49A | 4ll3A-1twwA:undetectable | 4ll3A-1twwA:17.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u2v | ARP2/3 COMPLEX 20KDASUBUNIT (Bos taurus) |
PF05856(ARPC4) | 4 | ALA F 19VAL F 51VAL F 61ILE F 63 | None | 0.71A | 4ll3A-1u2vF:undetectable | 4ll3A-1u2vF:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u3t | ALCOHOLDEHYDROGENASE ALPHACHAIN (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 70VAL A 169PRO A 329VAL A 328ILE A 90 | None | 1.21A | 4ll3A-1u3tA:undetectable | 4ll3A-1u3tA:13.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1urh | 3-MERCAPTOPYRUVATESULFURTRANSFERASE (Escherichiacoli) |
PF00581(Rhodanese) | 5 | ALA A 168VAL A 159GLY A 197VAL A 235ILE A 234 | None | 1.30A | 4ll3A-1urhA:undetectable | 4ll3A-1urhA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1usy | ATPPHOSPHORIBOSYLTRANSFERASE REGULATORYSUBUNIT (Thermotogamaritima) |
PF13393(tRNA-synt_His) | 4 | ALA C 251VAL C 114VAL C 109ILE C 113 | None | 0.65A | 4ll3A-1usyC:undetectable | 4ll3A-1usyC:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uwy | CARBOXYPEPTIDASE M (Homo sapiens) |
PF00246(Peptidase_M14)PF13620(CarboxypepD_reg) | 4 | VAL A 317GLY A 297VAL A 315ILE A 345 | None | 0.64A | 4ll3A-1uwyA:undetectable | 4ll3A-1uwyA:14.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5f | PYRUVATE OXIDASE (Aerococcusviridans) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ASP A 388ALA A 444ASP A 442VAL A 466ILE A 440 | NoneTPP A1602 (-3.7A) MG A1603 ( 2.8A)NoneNone | 1.00A | 4ll3A-1v5fA:undetectable | 4ll3A-1v5fA:11.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdt | ELONGATION FACTOR GHOMOLOG (Thermusthermophilus) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03764(EFG_IV)PF14492(EFG_II) | 5 | ALA A 237VAL A 213GLY A 231VAL A 208ILE A 212 | None | 0.86A | 4ll3A-1wdtA:undetectable | 4ll3A-1wdtA:9.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdt | ELONGATION FACTOR GHOMOLOG (Thermusthermophilus) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03764(EFG_IV)PF14492(EFG_II) | 5 | ASP A 216VAL A 213GLY A 231VAL A 208ILE A 212 | None | 1.06A | 4ll3A-1wdtA:undetectable | 4ll3A-1wdtA:9.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wsv | AMINOMETHYLTRANSFERASE (Homo sapiens) |
PF01571(GCV_T)PF08669(GCV_T_C) | 4 | VAL A 192GLY A 166VAL A 207ILE A 205 | VAL A 192 ( 0.6A)GLY A 166 ( 0.0A)VAL A 207 ( 0.6A)ILE A 205 ( 0.4A) | 0.65A | 4ll3A-1wsvA:undetectable | 4ll3A-1wsvA:13.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wu2 | MOLYBDOPTERINBIOSYNTHESIS MOEAPROTEIN (Pyrococcushorikoshii) |
PF00994(MoCF_biosynth)PF03453(MoeA_N)PF03454(MoeA_C) | 4 | ALA A 374VAL A 328VAL A 391ILE A 393 | None | 0.73A | 4ll3A-1wu2A:undetectable | 4ll3A-1wu2A:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wxj | TRYPTOPHAN SYNTHASEALPHA CHAIN (Thermusthermophilus) |
PF00290(Trp_syntA) | 5 | ALA A 206ASP A 224GLY A 169PRO A 93ILE A 19 | None | 1.32A | 4ll3A-1wxjA:undetectable | 4ll3A-1wxjA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aw5 | NADP-DEPENDENT MALICENZYME (Homo sapiens) |
PF00390(malic)PF03949(Malic_M) | 5 | ALA A 279VAL A 457GLY A 452VAL A 509ILE A 485 | None | 1.25A | 4ll3A-2aw5A:undetectable | 4ll3A-2aw5A:11.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2axo | HYPOTHETICAL PROTEINATU2684 (Agrobacteriumfabrum) |
PF06764(DUF1223) | 5 | ALA A 172VAL A 251GLY A 214PRO A 151VAL A 152 | None | 1.24A | 4ll3A-2axoA:undetectable | 4ll3A-2axoA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b8e | CATION-TRANSPORTINGATPASE (Archaeoglobusfulgidus) |
PF00702(Hydrolase) | 5 | ALA A 531ASP A 438VAL A 440VAL A 517ILE A 543 | None | 1.35A | 4ll3A-2b8eA:undetectable | 4ll3A-2b8eA:14.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cul | GLUCOSE-INHIBITEDDIVISION PROTEINA-RELATED PROTEIN,PROBABLEOXIDOREDUCTASE (Thermusthermophilus) |
PF01134(GIDA) | 5 | ALA A 19VAL A 6GLY A 220VAL A 9ILE A 8 | None | 1.42A | 4ll3A-2culA:undetectable | 4ll3A-2culA:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d0o | DIOLDEHYDRATASE-REACTIVATING FACTOR LARGESUBUNIT (Klebsiellaoxytoca) |
PF08841(DDR) | 5 | ASP A 276VAL A 275GLY A 299VAL A 288ILE A 284 | None | 1.26A | 4ll3A-2d0oA:undetectable | 4ll3A-2d0oA:10.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2db3 | ATP-DEPENDENT RNAHELICASE VASA (Drosophilamelanogaster) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | ALA A 461VAL A 465GLY A 292VAL A 561ILE A 577 | NoneNoneANP A2901 (-3.7A)NoneNone | 1.37A | 4ll3A-2db3A:undetectable | 4ll3A-2db3A:14.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpp | NITRILE HYDRATASEBETA SUBUNIT (Bacillus sp.RAPc8) |
PF02211(NHase_beta) | 4 | ALA B 165VAL B 215GLY B 8ILE B 217 | None | 0.64A | 4ll3A-2dppB:undetectable | 4ll3A-2dppB:16.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dr3 | UPF0273 PROTEINPH0284 (Pyrococcushorikoshii) |
PF06745(ATPase) | 4 | ALA A 129GLY A 84VAL A 89ILE A 55 | None | 0.75A | 4ll3A-2dr3A:undetectable | 4ll3A-2dr3A:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ehq | 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE (Thermusthermophilus) |
PF00171(Aldedh) | 5 | ALA A 206VAL A 233GLY A 216VAL A 195ILE A 194 | None | 1.34A | 4ll3A-2ehqA:undetectable | 4ll3A-2ehqA:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f2a | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A (Staphylococcusaureus) |
PF01425(Amidase) | 5 | ALA A 51GLY A 73PRO A 168VAL A 167ILE A 119 | None | 1.14A | 4ll3A-2f2aA:undetectable | 4ll3A-2f2aA:12.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f91 | HEPATOPANCREASTRYPSIN (Astacusleptodactylus) |
PF00089(Trypsin) | 5 | ASP A 189ALA A 220GLY A 223PRO A 161VAL A 160 | NoneNoneNone CL A 408 (-4.5A) CL A 408 ( 4.7A) | 1.36A | 4ll3A-2f91A:undetectable | 4ll3A-2f91A:18.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2faf | PHOSPHOENOLPYRUVATECARBOXYKINASE (Gallus gallus) |
PF00821(PEPCK_C)PF17297(PEPCK_N) | 5 | ALA A 449ASP A 448GLY A 288VAL A 555ILE A 559 | None | 1.25A | 4ll3A-2fafA:undetectable | 4ll3A-2fafA:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fdr | CONSERVEDHYPOTHETICAL PROTEIN (Agrobacteriumfabrum) |
PF13419(HAD_2) | 4 | ASP A 10GLY A 175VAL A 163ILE A 8 | MG A1001 (-3.0A)NoneNoneNone | 0.76A | 4ll3A-2fdrA:undetectable | 4ll3A-2fdrA:17.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 29GLY A 55ILE A 89 | LP1 A 201 (-2.3A)LP1 A 201 (-3.5A)LP1 A 201 (-3.6A)LP1 A 201 (-3.4A)LP1 A 201 (-4.2A) | 1.17A | 4ll3A-2fmbA:15.1 | 4ll3A-2fmbA:31.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 5 | ASP A 25ALA A 28VAL A 32GLY A 54ILE A 89 | LP1 A 201 (-2.3A)LP1 A 201 (-3.5A)NoneLP1 A 201 (-3.6A)LP1 A 201 (-4.2A) | 0.81A | 4ll3A-2fmbA:15.1 | 4ll3A-2fmbA:31.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 7 | ASP A 25ALA A 28VAL A 32GLY A 55PRO A 86VAL A 87ILE A 89 | LP1 A 201 (-2.3A)LP1 A 201 (-3.5A)NoneLP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 ( 4.9A)LP1 A 201 (-4.2A) | 0.47A | 4ll3A-2fmbA:15.1 | 4ll3A-2fmbA:31.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ft0 | TDP-FUCOSAMINEACETYLTRANSFERASE (Escherichiacoli) |
no annotation | 4 | ALA A 100GLY A 151VAL A 131ILE A 127 | None | 0.71A | 4ll3A-2ft0A:undetectable | 4ll3A-2ft0A:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fzw | ALCOHOLDEHYDROGENASE CLASSIII CHI CHAIN (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 69VAL A 168PRO A 328VAL A 327ILE A 89 | None | 1.29A | 4ll3A-2fzwA:undetectable | 4ll3A-2fzwA:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gep | SULFITE REDUCTASEHEMOPROTEIN (Escherichiacoli) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 5 | ASP A 227ALA A 394GLY A 89VAL A 221ILE A 228 | None | 1.35A | 4ll3A-2gepA:undetectable | 4ll3A-2gepA:11.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gko | SUBTILISINMICROBIAL SERINEPROTEINASES (Bacillussubtilis) |
PF00082(Peptidase_S8) | 4 | ALA A 96GLY A 91PRO A 253ILE A 30 | None | 0.75A | 4ll3A-2gkoA:undetectable | 4ll3A-2gkoA:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gmh | ELECTRON TRANSFERFLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE (Sus scrofa) |
PF05187(ETF_QO)PF13450(NAD_binding_8) | 5 | ALA A 51VAL A 38GLY A 374VAL A 41ILE A 40 | NoneNoneNoneFAD A 611 (-4.9A)None | 1.35A | 4ll3A-2gmhA:undetectable | 4ll3A-2gmhA:11.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hne | L-FUCONATEDEHYDRATASE (Xanthomonascampestris) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ALA A 127VAL A 79GLY A 49ILE A 83 | None | 0.75A | 4ll3A-2hneA:undetectable | 4ll3A-2hneA:12.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hqb | TRANSCRIPTIONALACTIVATOR OF COMKGENE (Bacillushalodurans) |
PF02608(Bmp) | 4 | ALA A 201VAL A 190GLY A 124ILE A 194 | None | 0.74A | 4ll3A-2hqbA:undetectable | 4ll3A-2hqbA:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ii1 | ACETAMIDASE (Bacillushalodurans) |
PF03069(FmdA_AmdA) | 4 | VAL A 202GLY A 132VAL A 83ILE A 81 | None CA A 400 ( 4.9A)NoneNone | 0.70A | 4ll3A-2ii1A:undetectable | 4ll3A-2ii1A:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ioy | PERIPLASMICSUGAR-BINDINGPROTEIN (Caldanaerobactersubterraneus) |
PF13407(Peripla_BP_4) | 4 | ALA A 27GLY A 245VAL A 36ILE A 34 | None | 0.63A | 4ll3A-2ioyA:undetectable | 4ll3A-2ioyA:15.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jhq | URACILDNA-GLYCOSYLASE (Vibrio cholerae) |
PF03167(UDG) | 5 | ASP A 9VAL A 10GLY A 54VAL A 148ILE A 11 | None | 1.31A | 4ll3A-2jhqA:undetectable | 4ll3A-2jhqA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jzl | CYANOVIRIN-N HOMOLOG (Neurosporacrassa) |
PF08881(CVNH) | 4 | ALA A 80GLY A 44VAL A 14ILE A 64 | None | 0.73A | 4ll3A-2jzlA:undetectable | 4ll3A-2jzlA:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m8e | SLEEPING BEAUTYTRANSPOSASE (syntheticconstruct) |
PF13384(HTH_23) | 5 | ASP A 19VAL A 18GLY A 24VAL A 41ILE A 17 | None | 1.30A | 4ll3A-2m8eA:undetectable | 4ll3A-2m8eA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n57 | ACYL CARRIER PROTEIN (Brucellamelitensis) |
PF00550(PP-binding) | 4 | ALA A 59ASP A 57VAL A 53ILE A 55 | None | 0.68A | 4ll3A-2n57A:undetectable | 4ll3A-2n57A:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nli | LACTATE OXIDASE (Aerococcusviridans) |
PF01070(FMN_dh) | 5 | ALA A 252ASP A 250VAL A 287PRO A 292ILE A 260 | None | 1.21A | 4ll3A-2nliA:undetectable | 4ll3A-2nliA:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nt4 | RESPONSE REGULATORHOMOLOG (Myxococcusxanthus) |
PF00072(Response_reg) | 5 | ALA A 99ASP A 100GLY A 67VAL A 54ILE A 82 | NoneNoneNone CL A 125 (-4.3A)None | 1.34A | 4ll3A-2nt4A:undetectable | 4ll3A-2nt4A:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o1s | 1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE (Escherichiacoli) |
PF02779(Transket_pyr)PF02780(Transketolase_C)PF13292(DXP_synthase_N) | 5 | ASP A 77ALA A 154ASP A 152VAL A 176ILE A 150 | NoneTDP A3001 (-3.6A) MG A1001 ( 2.7A)NoneNone | 1.43A | 4ll3A-2o1sA:undetectable | 4ll3A-2o1sA:9.18 |