SIMILAR PATTERNS OF AMINO ACIDS FOR 4LHM_A_AZZA510_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5z L-LACTATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 307
TYR A 278
VAL A 289
ILE A 287
LEU A 322
 None
 1.40A 4lhmA-1a5zA:
undetectable		 4lhmA-1a5zA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atg PERIPLASMIC
MOLYBDATE-BINDING
PROTEIN

(Azotobacter
vinelandii) 		PF13531
(SBP_bac_11) 		5 THR A   7
VAL A  30
ILE A  32
PHE A  54
LEU A  12
 None
 1.39A 4lhmA-1atgA:
undetectable		 4lhmA-1atgA:
23.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		7 THR A  84
ARG A 168
ILE A 180
SER A 183
LYS A 187
MET A 208
LEU A 217
 None
 0.78A 4lhmA-1brwA:
55.3		 4lhmA-1brwA:
43.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 THR A  84
LYS A 187
PHE A 207
MET A 208
LEU A 217
 None
 0.98A 4lhmA-1brwA:
55.3		 4lhmA-1brwA:
43.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 THR A  84
SER A 182
PHE A 207
MET A 208
LEU A 217
 None
 0.89A 4lhmA-1brwA:
55.3		 4lhmA-1brwA:
43.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		8 THR A  84
TYR A 165
ARG A 168
VAL A 174
ILE A 180
SER A 183
LYS A 187
LEU A 217
 None
 0.66A 4lhmA-1brwA:
55.3		 4lhmA-1brwA:
43.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 THR A  84
TYR A 165
LYS A 187
PHE A 207
LEU A 217
 None
 1.17A 4lhmA-1brwA:
55.3		 4lhmA-1brwA:
43.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 THR A 683
LEU A 668
VAL A 649
ILE A 600
LEU A 718
 B12  A 800 ( 4.9A)
None
None
None
None
 1.36A 4lhmA-1e1cA:
2.7		 4lhmA-1e1cA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		5 LEU A 551
VAL A 435
ILE A 558
PHE A 432
LEU A 565
 None
 1.42A 4lhmA-1fokA:
undetectable		 4lhmA-1fokA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 TYR A 591
VAL A 556
ILE A 585
MET A 606
LEU A 610
 None
 1.23A 4lhmA-1i8qA:
undetectable		 4lhmA-1i8qA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzo THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBC

(Escherichia
coli) 		PF10411
(DsbC_N)
PF13098
(Thioredoxin_2) 		5 TYR A 120
VAL A  92
ILE A  90
MET A 202
LEU A 206
 None
 1.20A 4lhmA-1jzoA:
undetectable		 4lhmA-1jzoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6h NON-SPECIFIC LIPID
TRANSFER PROTEIN

(Oryza sativa) 		PF14368
(LTP_2) 		5 THR A  67
LEU A  29
ILE A  15
SER A  59
PHE A  36
 None
 1.37A 4lhmA-1l6hA:
undetectable		 4lhmA-1l6hA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		5 THR A 414
VAL A 391
ILE A 389
PHE A 413
LEU A 447
 None
 1.49A 4lhmA-1ru3A:
4.0		 4lhmA-1ru3A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7k ACETYL TRANSFERASE

(Salmonella
enterica) 		PF13302
(Acetyltransf_3) 		5 TYR A  95
VAL A 131
ILE A  96
MET A 118
LEU A 114
 None
 1.50A 4lhmA-1s7kA:
undetectable		 4lhmA-1s7kA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u89 TALIN 1

(Mus musculus) 		no annotation 5 VAL A 808
ILE A 812
SER A 815
LYS A 751
MET A 870
 None
 1.37A 4lhmA-1u89A:
undetectable		 4lhmA-1u89A:
15.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uou THYMIDINE
PHOSPHORYLASE

(Homo sapiens) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		6 ARG A 202
VAL A 208
ILE A 214
SER A 217
LYS A 221
LEU A 251
 CMU  A1481 (-2.8A)
None
CMU  A1481 (-3.9A)
CMU  A1481 (-2.7A)
CMU  A1481 (-2.6A)
None
 0.32A 4lhmA-1uouA:
49.0		 4lhmA-1uouA:
38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uou THYMIDINE
PHOSPHORYLASE

(Homo sapiens) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 THR A 118
TYR A 199
SER A 217
LYS A 221
LEU A 251
 None
CMU  A1481 (-4.7A)
CMU  A1481 (-2.7A)
CMU  A1481 (-2.6A)
None
 1.07A 4lhmA-1uouA:
49.0		 4lhmA-1uouA:
38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uou THYMIDINE
PHOSPHORYLASE

(Homo sapiens) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		6 TYR A 199
ARG A 202
ILE A 214
SER A 217
LYS A 221
LEU A 251
 CMU  A1481 (-4.7A)
CMU  A1481 (-2.8A)
CMU  A1481 (-3.9A)
CMU  A1481 (-2.7A)
CMU  A1481 (-2.6A)
None
 0.66A 4lhmA-1uouA:
49.0		 4lhmA-1uouA:
38.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		5 LEU A  91
TYR A 242
ILE A 346
SER A 272
PHE A  96
 None
 1.47A 4lhmA-1up2A:
undetectable		 4lhmA-1up2A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkh PUTATIVE SERINE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF07859
(Abhydrolase_3) 		5 THR A 170
ILE A 153
SER A 110
PHE A 174
LEU A 159
 None
 1.46A 4lhmA-1vkhA:
undetectable		 4lhmA-1vkhA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xaj 3-DEHYDROQUINATE
SYNTHASE

(Staphylococcus
aureus) 		PF01761
(DHQ_synthase) 		5 THR A  79
LEU A  84
VAL A 117
ILE A  94
LEU A  37
 None
 1.35A 4lhmA-1xajA:
undetectable		 4lhmA-1xajA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 THR A 389
LEU A 386
ILE A 411
SER A 412
LEU A 400
 None
 1.17A 4lhmA-1xtjA:
undetectable		 4lhmA-1xtjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN

(Ovis aries) 		PF00230
(MIP) 		5 THR A 138
LEU A 168
TYR A  23
VAL A  67
PHE A 141
 None
 1.49A 4lhmA-2b6oA:
undetectable		 4lhmA-2b6oA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7h HEMOGLOBIN ALPHA
CHAIN

(Cerdocyon thous) 		PF00042
(Globin) 		5 LEU A 109
ILE A  10
SER A  12
PHE A 129
LEU A  73
 None
 1.48A 4lhmA-2b7hA:
undetectable		 4lhmA-2b7hA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ccm CALEXCITIN

(Doryteuthis
pealeii) 		no annotation 5 LEU A 107
TYR A  22
VAL A  17
ILE A  14
LEU A   6
 None
 1.18A 4lhmA-2ccmA:
undetectable		 4lhmA-2ccmA:
18.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		7 TYR A 164
ARG A 167
VAL A 173
ILE A 179
SER A 182
LYS A 186
LEU A 216
 None
None
CL  A1002 (-3.9A)
None
None
None
None
 0.34A 4lhmA-2dsjA:
51.5		 4lhmA-2dsjA:
41.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0w LMO2234 PROTEIN

(Listeria
monocytogenes) 		PF01261
(AP_endonuc_2) 		5 THR A 173
LEU A 152
VAL A 240
ILE A 197
SER A 196
 None
 1.30A 4lhmA-2g0wA:
undetectable		 4lhmA-2g0wA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jep XYLOGLUCANASE

(Paenibacillus
pabuli) 		PF00150
(Cellulase) 		5 LEU A 109
TYR A  92
VAL A  90
ILE A 128
LEU A 175
 None
 1.47A 4lhmA-2jepA:
undetectable		 4lhmA-2jepA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		5 THR A  33
LEU A 140
VAL A   5
ILE A 169
LEU A 157
 None
 1.49A 4lhmA-2qzxA:
undetectable		 4lhmA-2qzxA:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2tpt THYMIDINE
PHOSPHORYLASE

(Escherichia
coli) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		10 THR A  87
LEU A 117
TYR A 168
ARG A 171
VAL A 177
ILE A 183
SER A 186
LYS A 190
MET A 211
LEU A 220
 None
 0.64A 4lhmA-2tptA:
67.7		 4lhmA-2tptA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		5 THR A 237
LEU A  98
ILE A 229
MET A 109
LEU A 219
 None
 1.40A 4lhmA-2zbzA:
undetectable		 4lhmA-2zbzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ca8 PROTEIN YDCF

(Escherichia
coli) 		PF02698
(DUF218) 		5 THR A 213
LEU A 219
VAL A 243
ILE A  20
LEU A 250
 None
 1.47A 4lhmA-3ca8A:
undetectable		 4lhmA-3ca8A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqq PUTATIVE TRNA
SYNTHASE

(Salmonella
enterica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 THR A 111
LEU A 185
ILE A 113
SER A 114
PHE A 110
 None
 1.41A 4lhmA-3dqqA:
undetectable		 4lhmA-3dqqA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghj PUTATIVE INTEGRON
GENE CASSETTE
PROTEIN

(uncultured
bacterium) 		PF00903
(Glyoxalase) 		5 LEU A 115
VAL A  13
SER A  21
PHE A  70
LEU A  45
 None
 1.50A 4lhmA-3ghjA:
undetectable		 4lhmA-3ghjA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 VAL A  87
ILE A  52
SER A 111
PHE A  83
LEU A  15
 None
 1.21A 4lhmA-3h3zA:
undetectable		 4lhmA-3h3zA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h5q PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Staphylococcus
aureus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		9 THR A  84
TYR A 165
ARG A 168
VAL A 174
ILE A 180
SER A 183
LYS A 187
MET A 208
LEU A 217
 None
THM  A 434 (-4.0A)
THM  A 434 (-2.7A)
None
THM  A 434 (-4.2A)
THM  A 434 (-2.7A)
THM  A 434 (-2.8A)
None
None
 0.48A 4lhmA-3h5qA:
52.3		 4lhmA-3h5qA:
42.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6z POLYCOMB PROTEIN
SFMBT

(Drosophila
melanogaster) 		PF02820
(MBT) 		5 LEU A 936
VAL A 807
SER A 852
PHE A 860
LEU A 804
 None
 1.39A 4lhmA-3h6zA:
undetectable		 4lhmA-3h6zA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hde LYSOZYME

(Escherichia
virus Lambda) 		PF00959
(Phage_lysozyme) 		5 LEU A   5
ARG A 152
ILE A  25
SER A 104
LEU A  75
 None
 1.31A 4lhmA-3hdeA:
undetectable		 4lhmA-3hdeA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilh TWO COMPONENT
RESPONSE REGULATOR

(Cytophaga
hutchinsonii) 		PF00072
(Response_reg) 		5 THR A  25
LEU A 122
VAL A  10
ILE A  36
SER A  38
 None
 1.42A 4lhmA-3ilhA:
undetectable		 4lhmA-3ilhA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF05960
(DUF885) 		5 LEU A 536
TYR A 425
ILE A 524
PHE A 534
LEU A 559
 None
 1.29A 4lhmA-3iukA:
undetectable		 4lhmA-3iukA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb6 D-LACTATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 VAL A 113
ILE A 109
PHE A 163
MET A 165
LEU A 144
 None
 1.39A 4lhmA-3kb6A:
undetectable		 4lhmA-3kb6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 LEU A 151
TYR A  60
VAL A 114
ILE A  51
LEU A  48
 None
 1.43A 4lhmA-3mcxA:
undetectable		 4lhmA-3mcxA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 172
TYR A 290
VAL A 302
ILE A 299
PHE A 175
 None
 1.34A 4lhmA-3otrA:
undetectable		 4lhmA-3otrA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 367
VAL A   3
ILE A  69
MET A  20
LEU A  16
 None
 0.92A 4lhmA-3pzrA:
undetectable		 4lhmA-3pzrA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tj8 UREASE ACCESSORY
PROTEIN UREE

(Helicobacter
pylori) 		PF02814
(UreE_N)
PF05194
(UreE_C) 		5 THR A 116
LEU A 146
VAL A  91
ILE A  83
LEU A 126
 None
 1.28A 4lhmA-3tj8A:
undetectable		 4lhmA-3tj8A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF02141
(DENN)
PF03455
(dDENN)
PF03456
(uDENN) 		5 LEU A 261
TYR A 244
VAL A 197
ILE A 248
LEU A 252
 None
 1.46A 4lhmA-3tw8A:
undetectable		 4lhmA-3tw8A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Burkholderia
thailandensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 370
VAL A   3
ILE A  69
MET A  20
LEU A  16
 None
 1.36A 4lhmA-3uw3A:
undetectable		 4lhmA-3uw3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Burkholderia
thailandensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 371
VAL A   3
ILE A  69
MET A  20
LEU A  16
 None
 1.04A 4lhmA-3uw3A:
undetectable		 4lhmA-3uw3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE

(Aquifex
aeolicus) 		PF03841
(SelA) 		5 VAL A 214
ILE A 161
SER A 162
MET A 179
LEU A 186
 LLP  A 285 ( 4.7A)
None
None
None
None
 1.26A 4lhmA-3w1hA:
undetectable		 4lhmA-3w1hA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE

(Aquifex
aeolicus) 		PF03841
(SelA) 		5 VAL A 214
ILE A 161
SER A 162
MET A 179
LEU A 186
 None
 1.34A 4lhmA-3w1jA:
undetectable		 4lhmA-3w1jA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ypi TRIOSEPHOSPHATE
ISOMERASE

(Saccharomyces
cerevisiae) 		PF00121
(TIM) 		5 LEU A  93
VAL A 121
ILE A  83
SER A  79
LEU A  47
 None
 1.39A 4lhmA-3ypiA:
undetectable		 4lhmA-3ypiA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)

(Bacteroides
ovatus) 		PF00150
(Cellulase)
PF13004
(BACON) 		5 LEU A 153
TYR A 245
VAL A 205
ILE A 247
PHE A 367
 None
 1.39A 4lhmA-3zmrA:
undetectable		 4lhmA-3zmrA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF02811
(PHP) 		5 LEU A 145
ARG A 152
ILE A 160
PHE A 115
LEU A 126
 None
 1.44A 4lhmA-4gx8A:
undetectable		 4lhmA-4gx8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 THR A 193
LEU A 198
VAL A 161
ILE A 158
LEU A 153
 None
 1.38A 4lhmA-4hj2A:
undetectable		 4lhmA-4hj2A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilf THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBC

(Salmonella
enterica) 		PF10411
(DsbC_N)
PF13098
(Thioredoxin_2) 		5 TYR A 120
VAL A  92
ILE A  90
MET A 202
LEU A 206
 None
 1.13A 4lhmA-4ilfA:
undetectable		 4lhmA-4ilfA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5i ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Mycolicibacterium
smegmatis) 		PF02668
(TauD) 		5 THR A  96
TYR A 289
VAL A 101
ILE A 104
LEU A 195
 None
 1.38A 4lhmA-4j5iA:
undetectable		 4lhmA-4j5iA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5i ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Mycolicibacterium
smegmatis) 		PF02668
(TauD) 		5 THR A  96
VAL A 101
ILE A 104
PHE A 199
LEU A 195
 None
 1.21A 4lhmA-4j5iA:
undetectable		 4lhmA-4j5iA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1

(Rattus
norvegicus) 		PF00777
(Glyco_transf_29) 		5 TYR A 291
VAL A 175
ILE A 226
MET A 328
LEU A 206
 None
 1.37A 4lhmA-4mpsA:
undetectable		 4lhmA-4mpsA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA

(Klebsiella
pneumoniae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 THR H 538
LEU H 541
ILE H 536
SER H 507
PHE H 423
 None
 1.44A 4lhmA-4nl4H:
undetectable		 4lhmA-4nl4H:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npb PROTEIN DISULFIDE
ISOMERASE II

(Yersinia pestis) 		PF10411
(DsbC_N)
PF13098
(Thioredoxin_2) 		5 TYR A 141
VAL A 113
ILE A 111
MET A 223
LEU A 227
 None
 1.18A 4lhmA-4npbA:
undetectable		 4lhmA-4npbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl3 CHITINASE A

(Pteris
ryukyuensis) 		PF00704
(Glyco_hydro_18) 		5 VAL A 200
ILE A 242
SER A 278
PHE A 172
LEU A 268
 None
 1.48A 4lhmA-4rl3A:
undetectable		 4lhmA-4rl3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sli INTRAMOLECULAR
TRANS-SIALIDASE

(Macrobdella
decora) 		PF02973
(Sialidase)
PF13088
(BNR_2) 		5 TYR A 728
VAL A 704
ILE A 678
SER A 665
LEU A 755
 None
 1.33A 4lhmA-4sliA:
undetectable		 4lhmA-4sliA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0n BARDET-BIEDL
SYNDROME 1 PROTEIN

(Chlamydomonas
reinhardtii) 		PF14779
(BBS1) 		5 LEU B 418
VAL B 373
ILE B 363
PHE B 394
LEU B 392
 None
 1.42A 4lhmA-4v0nB:
undetectable		 4lhmA-4v0nB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w79 PROTEIN N-TERMINAL
GLUTAMINE
AMIDOHYDROLASE

(Homo sapiens) 		PF09764
(Nt_Gln_amidase) 		5 LEU A 175
TYR A  80
VAL A  82
SER A  56
PHE A 142
 None
 1.40A 4lhmA-4w79A:
undetectable		 4lhmA-4w79A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 THR A1306
LEU A1351
TYR A1511
VAL A1560
LEU A1553
 None
 1.43A 4lhmA-4xqkA:
undetectable		 4lhmA-4xqkA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0e PUTATIVE DIOXYGENASE

(Mycobacteroides
abscessus) 		PF02668
(TauD) 		5 THR A 105
VAL A 110
ILE A 113
PHE A 213
LEU A 209
 None
None
None
EPE  A 403 (-4.8A)
None
 1.20A 4lhmA-4y0eA:
undetectable		 4lhmA-4y0eA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
BETA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		PF02239
(Cytochrom_D1) 		5 THR B 232
VAL B 264
ILE B 266
MET B 317
LEU B 321
 None
 1.27A 4lhmA-5c2vB:
undetectable		 4lhmA-5c2vB:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm2 TRNA
METHYLTRANSFERASE

(Yarrowia
lipolytica) 		PF08241
(Methyltransf_11) 		5 LEU Z 145
VAL Z  61
ILE Z 120
SER Z 121
LEU Z  51
 None
 1.49A 4lhmA-5cm2Z:
undetectable		 4lhmA-5cm2Z:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 LEU B 666
VAL B 650
ILE B 656
SER B 655
LEU B 689
 None
 1.25A 4lhmA-5cxcB:
undetectable		 4lhmA-5cxcB:
22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Bacillus
subtilis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		8 THR A  84
TYR A 165
ARG A 168
VAL A 174
ILE A 180
SER A 183
MET A 208
LEU A 217
 THR  A  84 ( 0.8A)
TYR  A 165 ( 1.3A)
ARG  A 168 ( 0.6A)
VAL  A 174 ( 0.5A)
ILE  A 180 ( 0.7A)
SER  A 183 ( 0.0A)
MET  A 208 ( 0.0A)
LEU  A 217 ( 0.6A)
 0.63A 4lhmA-5ep8A:
52.9		 4lhmA-5ep8A:
45.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 SEGREGATION AND
CONDENSATION PROTEIN
A

(Bacillus
subtilis) 		PF02616
(SMC_ScpA) 		5 THR C 216
LEU C 221
ILE C 242
PHE C 217
LEU C 204
 None
 1.40A 4lhmA-5h67C:
undetectable		 4lhmA-5h67C:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j12 CYTOKINE
RECEPTOR-LIKE FACTOR
2

(Homo sapiens) 		no annotation 5 VAL C 170
ILE C 172
SER C 162
PHE C 127
LEU C 175
 None
 1.18A 4lhmA-5j12C:
undetectable		 4lhmA-5j12C:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5v TRNA NUCLEASE CDIA

(Escherichia
coli) 		PF15605
(Ntox28) 		5 LEU B 160
ILE B 218
SER B 220
MET B 182
LEU B 186
 None
 1.42A 4lhmA-5j5vB:
undetectable		 4lhmA-5j5vB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jx5 GLUCANASE

(Orpinomyces sp.
Y102) 		PF01341
(Glyco_hydro_6) 		5 VAL A 183
ILE A 229
SER A 228
MET A 243
LEU A 199
 None
None
EDO  A 511 ( 3.9A)
None
None
 1.40A 4lhmA-5jx5A:
undetectable		 4lhmA-5jx5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1u NAD(P)H:FLAVIN
OXIDOREDUCTASE SYE4

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		5 LEU A 188
TYR A 164
VAL A 218
PHE A 192
LEU A 256
 None
 1.44A 4lhmA-5k1uA:
undetectable		 4lhmA-5k1uA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks6 FLAGELLAR PROTEIN
FLIT

(Salmonella
enterica) 		PF05400
(FliT) 		5 THR A  71
LEU A  21
ILE A  44
SER A  43
LEU A 102
 None
 1.09A 4lhmA-5ks6A:
2.5		 4lhmA-5ks6A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE

(Astrosporangium
hypotensionis) 		PF01432
(Peptidase_M3) 		5 LEU A 195
ARG A 243
VAL A 187
ILE A 188
LEU A 215
 None
 1.34A 4lhmA-5l44A:
2.3		 4lhmA-5l44A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loi RAD26

(Thermothelomyces
thermophila) 		PF12331
(DUF3636) 		5 LEU A 824
TYR A 793
VAL A 677
ILE A 673
SER A 780
 None
 1.42A 4lhmA-5loiA:
1.7		 4lhmA-5loiA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpo MOLYBDOPTERIN
SYNTHASE SULFUR
CARRIER SUBUNIT

(Homo sapiens) 		PF02597
(ThiS) 		5 THR A  43
LEU A  48
TYR A  11
VAL A   9
ILE A  26
 None
 1.41A 4lhmA-5mpoA:
undetectable		 4lhmA-5mpoA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwr TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Sulfolobus
acidocaldarius) 		no annotation 5 LEU A 193
VAL A 157
ILE A 161
MET A  94
LEU A 165
 None
 1.49A 4lhmA-5mwrA:
undetectable		 4lhmA-5mwrA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 LEU A 745
TYR A 645
VAL A 643
MET A 797
LEU A 673
 None
 1.19A 4lhmA-5n0cA:
undetectable		 4lhmA-5n0cA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 LEU A 745
VAL A 643
ILE A 646
MET A 797
LEU A 673
 None
 1.41A 4lhmA-5n0cA:
undetectable		 4lhmA-5n0cA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyj ANBU

(Hyphomicrobium
sp. MC1) 		PF00227
(Proteasome) 		5 LEU A 160
TYR A   2
ILE A 117
PHE A   6
LEU A 129
 None
 1.34A 4lhmA-5nyjA:
undetectable		 4lhmA-5nyjA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwz ALDEHYDE
DECARBONYLASE

(Gloeobacter
violaceus) 		no annotation 5 TYR A  87
VAL A 185
ILE A  25
MET A 194
LEU A 192
 None
EDO  A 302 ( 4.8A)
STE  A 303 (-4.2A)
STE  A 303 (-4.0A)
None
 1.46A 4lhmA-5uwzA:
2.2		 4lhmA-5uwzA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wat HOMOSERINE KINASE

(Corynebacterium
glutamicum) 		no annotation 5 THR A 247
LEU A 254
VAL A 293
ILE A 291
SER A 289
 None
 1.27A 4lhmA-5watA:
undetectable		 4lhmA-5watA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x87 BESTROPHIN

(Klebsiella
pneumoniae) 		no annotation 5 LEU A 196
ILE A 150
SER A 153
PHE A 121
LEU A 138
 None
 1.14A 4lhmA-5x87A:
undetectable		 4lhmA-5x87A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xau LAMININ SUBUNIT
ALPHA-5

(Homo sapiens) 		PF02210
(Laminin_G_2)
PF06009
(Laminin_II) 		5 THR A3108
ILE A2954
SER A2955
PHE A2951
LEU A3103
 None
 1.33A 4lhmA-5xauA:
undetectable		 4lhmA-5xauA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY

(uncultured
archaeon
MedDCM-OCT-S05-C57) 		no annotation 5 LEU A 217
TYR A  67
ILE A  11
MET A 209
LEU A 166
 None
None
NAD  A 402 (-3.9A)
None
NAD  A 402 (-3.8A)
 1.23A 4lhmA-5y1gA:
3.2		 4lhmA-5y1gA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5

(Aquareovirus C) 		no annotation 5 LEU B 280
ILE B 274
SER B 598
PHE B 285
LEU B 514
 None
 1.35A 4lhmA-5zvtB:
undetectable		 4lhmA-5zvtB:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekt P-47 PROTEIN

(Clostridium
botulinum) 		no annotation 5 LEU A 399
VAL A 424
ILE A 432
PHE A 247
LEU A 240
 None
 1.43A 4lhmA-6ektA:
undetectable		 4lhmA-6ektA:
20.41