SIMILAR PATTERNS OF AMINO ACIDS FOR 4LF8_A_PARA1817_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ako EXONUCLEASE III

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		3 TYR A 215
ARG A  14
SER A 257
 None
 0.97A 4lf8I-1akoA:
0.0
4lf8J-1akoA:
0.0		 4lf8I-1akoA:
21.07
4lf8J-1akoA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdg HEXOKINASE

(Schistosoma
mansoni) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 TYR A 338
ARG A 327
SER A 333
 None
 1.15A 4lf8I-1bdgA:
0.0
4lf8J-1bdgA:
0.0		 4lf8I-1bdgA:
15.81
4lf8J-1bdgA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cot CYTOCHROME C2

(Paracoccus
denitrificans) 		no annotation 3 TYR A  55
ARG A  45
SER A  49
 HEM  A 130 (-4.5A)
HEM  A 130 (-4.0A)
None
 0.75A 4lf8I-1cotA:
0.0
4lf8J-1cotA:
undetectable		 4lf8I-1cotA:
23.61
4lf8J-1cotA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 TYR A  72
ARG A  67
SER A 424
 None
 0.84A 4lf8I-1f82A:
0.0
4lf8J-1f82A:
0.0		 4lf8I-1f82A:
14.11
4lf8J-1f82A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 TYR A 811
ARG A 237
SER A 240
 None
 0.87A 4lf8I-1h0hA:
0.0
4lf8J-1h0hA:
0.0		 4lf8I-1h0hA:
10.15
4lf8J-1h0hA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izo CYTOCHROME P450
152A1

(Bacillus
subtilis) 		PF00067
(p450) 		3 TYR A 249
ARG A 399
SER A 402
 None
 0.87A 4lf8I-1izoA:
0.3
4lf8J-1izoA:
undetectable		 4lf8I-1izoA:
17.22
4lf8J-1izoA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1je5 HELIX-DESTABILIZING
PROTEIN

(Escherichia
virus T7) 		no annotation 3 TYR A 153
ARG A  50
SER A   8
 None
 1.18A 4lf8I-1je5A:
0.0
4lf8J-1je5A:
0.0		 4lf8I-1je5A:
21.82
4lf8J-1je5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9w 3-DEHYDROQUINATE
DEHYDRATASE AROD

(Salmonella
enterica) 		PF01487
(DHquinase_I) 		3 TYR A  97
ARG A  82
SER A  83
 None
DHS  A 301 (-4.3A)
None
 1.05A 4lf8I-1l9wA:
0.0
4lf8J-1l9wA:
undetectable		 4lf8I-1l9wA:
20.48
4lf8J-1l9wA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 TYR B 237
ARG B 561
SER B 236
 None
 1.03A 4lf8I-1m2vB:
0.0
4lf8J-1m2vB:
0.0		 4lf8I-1m2vB:
8.86
4lf8J-1m2vB:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 TYR B 594
ARG B 208
SER B 593
 None
 1.17A 4lf8I-1m2vB:
0.0
4lf8J-1m2vB:
0.0		 4lf8I-1m2vB:
8.86
4lf8J-1m2vB:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mey CONSENSUS ZINC
FINGER

(-) 		PF13465
(zf-H2C2_2) 		3 TYR C  33
ARG C  25
SER C  43
 None
 1.11A 4lf8I-1meyC:
undetectable
4lf8J-1meyC:
undetectable		 4lf8I-1meyC:
20.16
4lf8J-1meyC:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mey CONSENSUS ZINC
FINGER

(-) 		PF13465
(zf-H2C2_2) 		3 TYR C  61
ARG C  53
SER C  71
 None
 1.03A 4lf8I-1meyC:
undetectable
4lf8J-1meyC:
undetectable		 4lf8I-1meyC:
20.16
4lf8J-1meyC:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ow0 IMMUNOGLOBULIN ALPHA
FC RECEPTOR

(Homo sapiens) 		no annotation 3 TYR C 173
ARG C 171
SER C 187
 None
 1.11A 4lf8I-1ow0C:
undetectable
4lf8J-1ow0C:
undetectable		 4lf8I-1ow0C:
18.98
4lf8J-1ow0C:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 TYR A 237
ARG A 561
SER A 236
 None
None
ZN  A 950 ( 4.9A)
 0.99A 4lf8I-1pd1A:
undetectable
4lf8J-1pd1A:
undetectable		 4lf8I-1pd1A:
10.00
4lf8J-1pd1A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		3 TYR A 481
ARG A 213
SER A 554
 None
 1.00A 4lf8I-1qhbA:
undetectable
4lf8J-1qhbA:
undetectable		 4lf8I-1qhbA:
12.84
4lf8J-1qhbA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		3 TYR A 436
ARG A 415
SER A 347
 None
 0.75A 4lf8I-1r6vA:
undetectable
4lf8J-1r6vA:
3.5		 4lf8I-1r6vA:
11.24
4lf8J-1r6vA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus) 		PF06283
(ThuA) 		3 TYR A 194
ARG A 196
SER A 181
 None
 1.17A 4lf8I-1t0bA:
undetectable
4lf8J-1t0bA:
undetectable		 4lf8I-1t0bA:
18.55
4lf8J-1t0bA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		3 TYR A 370
ARG A 342
SER A 369
 CIT  A1649 (-4.5A)
CIT  A1649 ( 2.9A)
GOL  A1653 (-2.7A)
 1.11A 4lf8I-1w8oA:
undetectable
4lf8J-1w8oA:
undetectable		 4lf8I-1w8oA:
11.15
4lf8J-1w8oA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whw HYPOTHETICAL PROTEIN
RIKEN CDNA
1200009A02

(Mus musculus) 		PF00076
(RRM_1) 		3 TYR A  47
ARG A 107
SER A  46
 None
 0.82A 4lf8I-1whwA:
undetectable
4lf8J-1whwA:
2.5		 4lf8I-1whwA:
22.22
4lf8J-1whwA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		3 TYR A 128
ARG A  27
SER A 126
 None
 1.17A 4lf8I-2a5hA:
undetectable
4lf8J-2a5hA:
undetectable		 4lf8I-2a5hA:
16.26
4lf8J-2a5hA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bh5 CYTOCHROME C-550

(Paracoccus
versutus) 		no annotation 3 TYR X  55
ARG X  45
SER X  49
 HEC  X1123 (-4.5A)
HEC  X1123 (-4.0A)
None
 0.75A 4lf8I-2bh5X:
undetectable
4lf8J-2bh5X:
undetectable		 4lf8I-2bh5X:
23.74
4lf8J-2bh5X:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A

(Starkeya
novella) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		3 TYR A 186
ARG A 132
SER A 187
 None
 1.11A 4lf8I-2ca4A:
undetectable
4lf8J-2ca4A:
undetectable		 4lf8I-2ca4A:
16.80
4lf8J-2ca4A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqc ARGININE/SERINE-RICH
SPLICING FACTOR 10

(Homo sapiens) 		PF00076
(RRM_1) 		3 TYR A 128
ARG A 187
SER A 126
 None
 1.09A 4lf8I-2cqcA:
undetectable
4lf8J-2cqcA:
undetectable		 4lf8I-2cqcA:
20.49
4lf8J-2cqcA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d96 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT

(Homo sapiens) 		PF00531
(Death) 		3 TYR A  49
ARG A  61
SER A  58
 None
 0.98A 4lf8I-2d96A:
undetectable
4lf8J-2d96A:
undetectable		 4lf8I-2d96A:
19.70
4lf8J-2d96A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fc9 NCL PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		3 TYR A  25
ARG A  81
SER A  24
 None
 1.05A 4lf8I-2fc9A:
undetectable
4lf8J-2fc9A:
undetectable		 4lf8I-2fc9A:
19.70
4lf8J-2fc9A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7g RHA04620, PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF02909
(TetR_C) 		3 TYR A 115
ARG A  59
SER A 111
 None
 1.13A 4lf8I-2g7gA:
undetectable
4lf8J-2g7gA:
undetectable		 4lf8I-2g7gA:
21.33
4lf8J-2g7gA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiv THERMOSTABLE DNA
LIGASE

(Sulfolobus
solfataricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 TYR A 472
ARG A 512
SER A 478
 None
 1.20A 4lf8I-2hivA:
undetectable
4lf8J-2hivA:
undetectable		 4lf8I-2hivA:
12.54
4lf8J-2hivA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i13 AART

(Mus musculus) 		PF00096
(zf-C2H2)
PF13465
(zf-H2C2_2) 		3 TYR A  78
ARG A  70
SER A  88
 None
 1.19A 4lf8I-2i13A:
undetectable
4lf8J-2i13A:
undetectable		 4lf8I-2i13A:
18.82
4lf8J-2i13A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc4 EXODEOXYRIBONUCLEASE
III

(Neisseria
meningitidis) 		PF03372
(Exo_endo_phos) 		3 TYR A 203
ARG A  14
SER A 245
 None
 1.12A 4lf8I-2jc4A:
undetectable
4lf8J-2jc4A:
undetectable		 4lf8I-2jc4A:
18.50
4lf8J-2jc4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2km8 MRNA
3'-END-PROCESSING
PROTEIN RNA15

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		3 TYR B  69
ARG B  95
SER B  32
 A  A   9 ( 2.9A)
A  A   8 ( 3.2A)
None
 0.73A 4lf8I-2km8B:
undetectable
4lf8J-2km8B:
3.2		 4lf8I-2km8B:
19.23
4lf8J-2km8B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxn TRANSFORMER-2
PROTEIN HOMOLOG BETA

(Homo sapiens) 		PF00076
(RRM_1) 		3 TYR B 128
ARG B 187
SER B 126
 None
A  A   1 ( 4.4A)
None
 1.20A 4lf8I-2kxnB:
undetectable
4lf8J-2kxnB:
2.1		 4lf8I-2kxnB:
21.28
4lf8J-2kxnB:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2llz UNCHARACTERIZED
PROTEIN YJDK

(Escherichia
coli) 		PF11080
(GhoS) 		3 TYR A  34
ARG A  30
SER A  31
 None
 0.85A 4lf8I-2llzA:
undetectable
4lf8J-2llzA:
3.0		 4lf8I-2llzA:
23.31
4lf8J-2llzA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6e PROTELEMORASE

(Klebsiella
phage phiKO2) 		PF16684
(Telomere_res) 		3 TYR A 386
ARG A 274
SER A 272
 None
 0.92A 4lf8I-2v6eA:
undetectable
4lf8J-2v6eA:
undetectable		 4lf8I-2v6eA:
11.90
4lf8J-2v6eA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vil VILLIN 14T

(Gallus gallus) 		PF00626
(Gelsolin) 		3 TYR A 109
ARG A  51
SER A  49
 None
 1.22A 4lf8I-2vilA:
undetectable
4lf8J-2vilA:
undetectable		 4lf8I-2vilA:
20.86
4lf8J-2vilA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voa EXODEOXYRIBONUCLEASE
III

(Archaeoglobus
fulgidus) 		PF03372
(Exo_endo_phos) 		3 TYR A 203
ARG A  15
SER A 246
 None
 1.01A 4lf8I-2voaA:
undetectable
4lf8J-2voaA:
undetectable		 4lf8I-2voaA:
20.88
4lf8J-2voaA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22)
PF01163
(RIO1) 		3 TYR A 190
ARG A 368
SER A 229
 None
 1.11A 4lf8I-2vwbA:
1.8
4lf8J-2vwbA:
2.2		 4lf8I-2vwbA:
14.74
4lf8J-2vwbA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhh REDOX-SENSITIVE
TRANSCRIPTIONAL
ACTIVATOR SOXR

(Escherichia
coli) 		PF00376
(MerR)
PF09278
(MerR-DNA-bind) 		3 TYR A  49
ARG A  47
SER A  39
 None
 1.19A 4lf8I-2zhhA:
undetectable
4lf8J-2zhhA:
undetectable		 4lf8I-2zhhA:
20.73
4lf8J-2zhhA:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		3 TYR A  36
ARG A 211
SER A 181
 None
 1.18A 4lf8I-2zq5A:
undetectable
4lf8J-2zq5A:
undetectable		 4lf8I-2zq5A:
18.18
4lf8J-2zq5A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byv RHOPTRY KINASE

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		3 TYR A 422
ARG A 457
SER A 456
 None
 1.19A 4lf8I-3byvA:
undetectable
4lf8J-3byvA:
undetectable		 4lf8I-3byvA:
18.23
4lf8J-3byvA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT

(Escherichia
coli) 		PF13085
(Fer2_3)
PF13183
(Fer4_8) 		3 TYR B 142
ARG B 184
SER B 183
 None
 1.06A 4lf8I-3cirB:
undetectable
4lf8J-3cirB:
undetectable		 4lf8I-3cirB:
20.00
4lf8J-3cirB:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		3 TYR A 296
ARG A 307
SER A 299
 None
 1.08A 4lf8I-3ctzA:
undetectable
4lf8J-3ctzA:
undetectable		 4lf8I-3ctzA:
11.41
4lf8J-3ctzA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr PROTEIN VP2

(Rhinovirus A) 		PF00073
(Rhv) 		3 TYR B 144
ARG B 216
SER B 217
 None
 1.08A 4lf8I-3dprB:
undetectable
4lf8J-3dprB:
undetectable		 4lf8I-3dprB:
17.60
4lf8J-3dprB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8

(Homo sapiens) 		PF12134
(PRP8_domainIV) 		3 TYR A1768
ARG A2008
SER A1765
 None
 1.18A 4lf8I-3e9lA:
undetectable
4lf8J-3e9lA:
undetectable		 4lf8I-3e9lA:
22.71
4lf8J-3e9lA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 TYR A 366
ARG A 172
SER A 362
 None
 1.21A 4lf8I-3fn9A:
undetectable
4lf8J-3fn9A:
undetectable		 4lf8I-3fn9A:
13.04
4lf8J-3fn9A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js3 3-DEHYDROQUINATE
DEHYDRATASE

(Clostridioides
difficile) 		PF01487
(DHquinase_I) 		3 TYR A  98
ARG A  83
SER A  84
 None
DHS  A 301 (-3.9A)
None
 1.15A 4lf8I-3js3A:
undetectable
4lf8J-3js3A:
undetectable		 4lf8I-3js3A:
15.83
4lf8J-3js3A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3q BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 TYR B 233
ARG B 113
SER B 110
 None
 1.21A 4lf8I-3k3qB:
undetectable
4lf8J-3k3qB:
undetectable		 4lf8I-3k3qB:
18.95
4lf8J-3k3qB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		3 TYR A  11
ARG A 359
SER A 356
 SO4  A1504 (-4.7A)
None
SO4  A1504 (-2.6A)
 1.01A 4lf8I-3kehA:
undetectable
4lf8J-3kehA:
undetectable		 4lf8I-3kehA:
15.29
4lf8J-3kehA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1

(Homo sapiens) 		PF00962
(A_deaminase)
PF08451
(A_deaminase_N) 		3 TYR A 264
ARG A 222
SER A 265
 None
 0.89A 4lf8I-3lggA:
undetectable
4lf8J-3lggA:
undetectable		 4lf8I-3lggA:
14.14
4lf8J-3lggA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0g ISOPRENE SYNTHASE

(Populus tremula
x Populus alba) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 TYR A 438
ARG A 486
SER A 506
 None
DST  A 601 (-3.1A)
None
 1.05A 4lf8I-3n0gA:
undetectable
4lf8J-3n0gA:
undetectable		 4lf8I-3n0gA:
13.29
4lf8J-3n0gA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pig BETA-FRUCTOFURANOSID
ASE

(Bifidobacterium
longum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 TYR A 485
ARG A 433
SER A 484
 None
 0.96A 4lf8I-3pigA:
undetectable
4lf8J-3pigA:
undetectable		 4lf8I-3pigA:
12.95
4lf8J-3pigA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis) 		PF00128
(Alpha-amylase) 		3 TYR A 638
ARG A 367
SER A 598
 None
 0.82A 4lf8I-3ucqA:
undetectable
4lf8J-3ucqA:
undetectable		 4lf8I-3ucqA:
12.30
4lf8J-3ucqA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3e COTYLEDONEOUS
YIELDIN-LIKE PROTEIN

(Vigna
unguiculata) 		PF00182
(Glyco_hydro_19) 		3 TYR A 110
ARG A  96
SER A 109
 None
 1.10A 4lf8I-3w3eA:
undetectable
4lf8J-3w3eA:
0.3		 4lf8I-3w3eA:
20.18
4lf8J-3w3eA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ays AMYLOSUCRASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase) 		3 TYR A 635
ARG A 359
SER A 595
 None
 1.07A 4lf8I-4aysA:
undetectable
4lf8J-4aysA:
undetectable		 4lf8I-4aysA:
12.26
4lf8J-4aysA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6z FAMILY M14
UNASSIGNED PEPTIDASE

(Burkholderia
cenocepacia) 		PF00246
(Peptidase_M14) 		3 TYR A  72
ARG A  85
SER A  73
 None
 1.03A 4lf8I-4b6zA:
undetectable
4lf8J-4b6zA:
0.3		 4lf8I-4b6zA:
15.72
4lf8J-4b6zA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		3 TYR A 645
ARG A 512
SER A 568
 None
 1.17A 4lf8I-4cakA:
undetectable
4lf8J-4cakA:
undetectable		 4lf8I-4cakA:
9.41
4lf8J-4cakA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 TYR A  57
ARG A 654
SER A 687
 None
 1.18A 4lf8I-4ddwA:
undetectable
4lf8J-4ddwA:
undetectable		 4lf8I-4ddwA:
7.96
4lf8J-4ddwA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Candida
albicans;
Escherichia
coli) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		3 TYR A -29
ARG A-304
SER A -33
 MTT  A 701 (-4.6A)
MTT  A 701 (-3.8A)
None
 1.11A 4lf8I-4h1gA:
undetectable
4lf8J-4h1gA:
undetectable		 4lf8I-4h1gA:
10.81
4lf8J-4h1gA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3s GLUTAMINE-TRNA
LIGASE

(Saccharomyces
cerevisiae) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2) 		3 TYR A 326
ARG A 289
SER A 323
 None
 0.97A 4lf8I-4h3sA:
undetectable
4lf8J-4h3sA:
undetectable		 4lf8I-4h3sA:
10.26
4lf8J-4h3sA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht1 CHIMERIC ANTIBODY
FAB

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR L  93
ARG L  96
SER L  95
 None
 1.19A 4lf8I-4ht1L:
undetectable
4lf8J-4ht1L:
undetectable		 4lf8I-4ht1L:
23.66
4lf8J-4ht1L:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iov CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		3 TYR A 610
ARG A 727
SER A 726
 None
 1.10A 4lf8I-4iovA:
undetectable
4lf8J-4iovA:
0.2		 4lf8I-4iovA:
12.45
4lf8J-4iovA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN

(Micromonospora
viridifaciens) 		PF13088
(BNR_2) 		3 TYR A 370
ARG A 342
SER A 369
 None
 1.05A 4lf8I-4j9tA:
undetectable
4lf8J-4j9tA:
undetectable		 4lf8I-4j9tA:
20.28
4lf8J-4j9tA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrf PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
ovatus) 		PF15495
(Fimbrillin_C) 		3 TYR A 251
ARG A 267
SER A 252
 None
 0.93A 4lf8I-4jrfA:
undetectable
4lf8J-4jrfA:
undetectable		 4lf8I-4jrfA:
13.00
4lf8J-4jrfA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kz1 VIRB8 PROTEIN

(Bartonella
grahamii) 		PF04335
(VirB8) 		3 TYR A  43
ARG A  50
SER A  46
 None
 1.15A 4lf8I-4kz1A:
undetectable
4lf8J-4kz1A:
undetectable		 4lf8I-4kz1A:
22.16
4lf8J-4kz1A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovy HALOACID
DEHALOGENASE DOMAIN
PROTEIN HYDROLASE

(Planctopirus
limnophila) 		PF12710
(HAD) 		3 TYR A  42
ARG A  53
SER A  45
 None
 1.22A 4lf8I-4ovyA:
undetectable
4lf8J-4ovyA:
undetectable		 4lf8I-4ovyA:
17.67
4lf8J-4ovyA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2c SHIGA TOXIN 2E,
SUBUNIT B

(Escherichia
coli) 		PF02258
(SLT_beta) 		3 TYR B  28
ARG B  26
SER B  58
 None
 0.94A 4lf8I-4p2cB:
undetectable
4lf8J-4p2cB:
undetectable		 4lf8I-4p2cB:
21.98
4lf8J-4p2cB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptz FMN REDUCTASE SSUE

(Escherichia
coli) 		no annotation 3 TYR C 146
ARG C  10
SER C  13
 None
FMN  C 202 ( 3.0A)
FMN  C 201 (-2.5A)
 0.98A 4lf8I-4ptzC:
undetectable
4lf8J-4ptzC:
undetectable		 4lf8I-4ptzC:
24.62
4lf8J-4ptzC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r29 UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		no annotation 3 TYR A 204
ARG A 107
SER A 203
 SAM  A 301 (-4.5A)
SAM  A 301 (-2.7A)
None
 1.12A 4lf8I-4r29A:
undetectable
4lf8J-4r29A:
0.6		 4lf8I-4r29A:
19.38
4lf8J-4r29A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6y NANOBODY NBFEDF9

(Lama glama) 		PF07686
(V-set) 		3 TYR B  59
ARG B 112
SER B 110
 SO4  B 202 (-4.3A)
SO4  B 202 (-2.9A)
None
 1.09A 4lf8I-4w6yB:
undetectable
4lf8J-4w6yB:
undetectable		 4lf8I-4w6yB:
20.42
4lf8J-4w6yB:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 3 TYR A 254
ARG A 435
SER A 376
 None
 1.17A 4lf8I-4wseA:
undetectable
4lf8J-4wseA:
undetectable		 4lf8I-4wseA:
13.26
4lf8J-4wseA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x6k ANHYDROSIALIDASE

([Ruminococcus]
gnavus) 		PF13088
(BNR_2) 		3 TYR A 677
ARG A 637
SER A 676
 3XR  A 802 (-4.2A)
3XR  A 802 (-3.0A)
None
 1.12A 4lf8I-4x6kA:
undetectable
4lf8J-4x6kA:
undetectable		 4lf8I-4x6kA:
14.47
4lf8J-4x6kA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001) 		PF01425
(Amidase) 		3 TYR A 221
ARG A 464
SER A 439
 None
 1.04A 4lf8I-4yjiA:
undetectable
4lf8J-4yjiA:
undetectable		 4lf8I-4yjiA:
14.20
4lf8J-4yjiA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yw5 NEURAMINIDASE C

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		3 TYR A 695
ARG A 662
SER A 694
 G39  A 801 (-4.4A)
G39  A 801 (-2.9A)
None
 1.15A 4lf8I-4yw5A:
undetectable
4lf8J-4yw5A:
undetectable		 4lf8I-4yw5A:
11.95
4lf8J-4yw5A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		3 TYR A 705
ARG A 726
SER A 703
 None
 0.87A 4lf8I-4zgvA:
undetectable
4lf8J-4zgvA:
undetectable		 4lf8I-4zgvA:
9.79
4lf8J-4zgvA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		3 TYR A 814
ARG A 752
SER A 815
 None
 0.91A 4lf8I-4zgvA:
undetectable
4lf8J-4zgvA:
undetectable		 4lf8I-4zgvA:
9.79
4lf8J-4zgvA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		3 TYR A 653
ARG A 439
SER A 437
 None
 1.21A 4lf8I-4zmhA:
undetectable
4lf8J-4zmhA:
undetectable		 4lf8I-4zmhA:
8.74
4lf8J-4zmhA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 TYR A 419
ARG A 393
SER A 229
 None
 0.85A 4lf8I-4zxiA:
undetectable
4lf8J-4zxiA:
undetectable		 4lf8I-4zxiA:
6.68
4lf8J-4zxiA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd6 TPR-DOMAIN
CONTAINING PROTEIN

(Parabacteroides
distasonis) 		PF17128
(DUF5107) 		3 TYR A  61
ARG A 122
SER A  60
 None
 1.08A 4lf8I-5cd6A:
undetectable
4lf8J-5cd6A:
undetectable		 4lf8I-5cd6A:
12.48
4lf8J-5cd6A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eh2 HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9

(Homo sapiens) 		PF00096
(zf-C2H2) 		3 TYR E 803
ARG E 795
SER E 813
 None
 1.21A 4lf8I-5eh2E:
undetectable
4lf8J-5eh2E:
undetectable		 4lf8I-5eh2E:
22.82
4lf8J-5eh2E:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ekp UNCHARACTERIZED
GLYCOSYLTRANSFERASE
SLL0501

(Synechocystis
sp. PCC 6803) 		no annotation 3 TYR C 301
ARG C 175
SER C  79
 None
 0.87A 4lf8I-5ekpC:
undetectable
4lf8J-5ekpC:
undetectable		 4lf8I-5ekpC:
14.41
4lf8J-5ekpC:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcc HUTD

(Pseudomonas
fluorescens) 		PF05962
(HutD) 		3 TYR A  59
ARG A 117
SER A 114
 NA  A 205 (-4.5A)
EDO  A 202 (-3.9A)
None
 1.03A 4lf8I-5fccA:
undetectable
4lf8J-5fccA:
undetectable		 4lf8I-5fccA:
19.80
4lf8J-5fccA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjp O-SUCCINYLBENZOATE
SYNTHASE

(Amycolatopsis
sp.) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A 324
ARG A 299
SER A 320
 None
 1.10A 4lf8I-5fjpA:
undetectable
4lf8J-5fjpA:
undetectable		 4lf8I-5fjpA:
21.74
4lf8J-5fjpA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC97
TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C)
PF04130
(Spc97_Spc98) 		3 TYR C 445
ARG A 624
SER C 444
 None
 1.21A 4lf8I-5flzC:
undetectable
4lf8J-5flzC:
undetectable		 4lf8I-5flzC:
14.16
4lf8J-5flzC:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		3 TYR C 109
ARG C 193
SER C 152
 None
 1.15A 4lf8I-5flzC:
undetectable
4lf8J-5flzC:
undetectable		 4lf8I-5flzC:
14.16
4lf8J-5flzC:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fol LEUCYL-TRNA
SYNTHETASE

(Cryptosporidium
muris) 		no annotation 3 TYR A 539
ARG A 351
SER A 352
 None
 1.07A 4lf8I-5folA:
undetectable
4lf8J-5folA:
undetectable		 4lf8I-5folA:
20.34
4lf8J-5folA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 3 TYR A 246
ARG A 278
SER A 275
 None
 1.22A 4lf8I-5i5jA:
undetectable
4lf8J-5i5jA:
undetectable		 4lf8I-5i5jA:
13.20
4lf8J-5i5jA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Mycobacterium
tuberculosis) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		3 TYR A  87
ARG A  85
SER A  84
 None
 1.21A 4lf8I-5i67A:
undetectable
4lf8J-5i67A:
undetectable		 4lf8I-5i67A:
11.59
4lf8J-5i67A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04453
(OstA_C) 		3 TYR A 123
ARG A 127
SER A 124
 None
 1.18A 4lf8I-5ivaA:
undetectable
4lf8J-5ivaA:
undetectable		 4lf8I-5ivaA:
12.35
4lf8J-5ivaA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1

(Saccharomyces
cerevisiae) 		PF04950
(RIBIOP_C)
PF08142
(AARP2CN) 		3 TYR A 188
ARG A 248
SER A 187
 None
 1.12A 4lf8I-5iw7A:
undetectable
4lf8J-5iw7A:
undetectable		 4lf8I-5iw7A:
10.71
4lf8J-5iw7A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbw RIBOFLAVIN
TRANSPORTER RIBU

(Thermotoga
maritima) 		PF12822
(ECF_trnsprt) 		3 TYR A  95
ARG A 101
SER A 100
 None
 1.09A 4lf8I-5kbwA:
undetectable
4lf8J-5kbwA:
undetectable		 4lf8I-5kbwA:
22.70
4lf8J-5kbwA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
ALPHA TYPE-7

(Homo sapiens) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		3 TYR C 110
ARG C 117
SER C 113
 None
 1.03A 4lf8I-5m32C:
undetectable
4lf8J-5m32C:
undetectable		 4lf8I-5m32C:
22.55
4lf8J-5m32C:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		3 TYR A1017
ARG A1013
SER A1014
 None
 1.21A 4lf8I-5mqsA:
undetectable
4lf8J-5mqsA:
undetectable		 4lf8I-5mqsA:
8.55
4lf8J-5mqsA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 3 TYR A 620
ARG A 364
SER A 582
 None
 0.94A 4lf8I-5n6vA:
undetectable
4lf8J-5n6vA:
undetectable		 4lf8I-5n6vA:
19.23
4lf8J-5n6vA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odb D10 FAB FRAGMENT -
LIGHT CHAIN

(Homo sapiens) 		no annotation 3 TYR B 192
ARG B 209
SER B 190
 None
 0.54A 4lf8I-5odbB:
undetectable
4lf8J-5odbB:
undetectable		 4lf8I-5odbB:
17.56
4lf8J-5odbB:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		3 TYR A1422
ARG A1111
SER A1421
 None
 1.21A 4lf8I-5u1sA:
undetectable
4lf8J-5u1sA:
undetectable		 4lf8I-5u1sA:
6.02
4lf8J-5u1sA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bacillus
anthracis) 		PF00496
(SBP_bac_5) 		3 TYR A 167
ARG A 469
SER A 168
 None
 1.20A 4lf8I-5u4oA:
undetectable
4lf8J-5u4oA:
undetectable		 4lf8I-5u4oA:
14.29
4lf8J-5u4oA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 TYR A1151
ARG A1147
SER A1148
 None
 0.96A 4lf8I-5ujaA:
undetectable
4lf8J-5ujaA:
undetectable		 4lf8I-5ujaA:
7.20
4lf8J-5ujaA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3g PR DOMAIN ZINC
FINGER PROTEIN 9

(Homo sapiens) 		no annotation 3 TYR D 803
ARG D 795
SER D 813
 None
 1.20A 4lf8I-5v3gD:
undetectable
4lf8J-5v3gD:
undetectable		 4lf8I-5v3gD:
20.22
4lf8J-5v3gD:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		3 TYR A 325
ARG A 332
SER A 329
 None
 1.01A 4lf8I-5xhqA:
undetectable
4lf8J-5xhqA:
undetectable		 4lf8I-5xhqA:
14.37
4lf8J-5xhqA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 3 TYR A1757
ARG A  86
SER A1664
 None
 1.15A 4lf8I-5zalA:
undetectable
4lf8J-5zalA:
undetectable		 4lf8I-5zalA:
19.53
4lf8J-5zalA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-) 		no annotation 3 TYR D 423
ARG D 456
SER D 480
 None
 1.16A 4lf8I-6gsaD:
undetectable
4lf8J-6gsaD:
undetectable		 4lf8I-6gsaD:
undetectable
4lf8J-6gsaD:
undetectable