SIMILAR PATTERNS OF AMINO ACIDS FOR 4LBG_B_ADNB402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)


(Sulfolobus
solfataricus)
PF01113
(DapB_N)
PF02800
(Gp_dh_C)
5 GLU O 307
ILE O 105
ALA O 128
ALA O 314
ILE O 134
None
1.08A 4lbgB-1b7gO:
6.7
4lbgB-1b7gO:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 ALA A 237
ILE A 244
VAL A 112
ALA A  24
ALA A  27
None
1.04A 4lbgB-1coyA:
undetectable
4lbgB-1coyA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp2 NITROGENASE IRON
PROTEIN


(Clostridium
pasteurianum)
PF00142
(Fer4_NifH)
5 ALA A 133
ILE A 165
ALA A   5
ALA A 141
ILE A 144
None
1.08A 4lbgB-1cp2A:
3.5
4lbgB-1cp2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)


(Paracoccus
denitrificans)
PF00766
(ETF_alpha)
PF01012
(ETF)
5 ALA A  70
ILE B 170
VAL B 159
ALA B 176
ALA B 142
None
1.09A 4lbgB-1efpA:
2.4
4lbgB-1efpA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnz GSI-B4 ISOLECTIN

(Griffonia
simplicifolia)
PF00139
(Lectin_legB)
5 THR A 227
ALA A 218
ILE A 216
CYH A  36
ILE A 230
None
1.06A 4lbgB-1gnzA:
undetectable
4lbgB-1gnzA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1huq RAB5C

(Mus musculus)
PF00071
(Ras)
5 GLU A 118
ALA A 123
ILE A 129
VAL A  99
ALA A  94
None
1.10A 4lbgB-1huqA:
3.2
4lbgB-1huqA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT


(Klebsiella
pneumoniae)
PF02286
(Dehydratase_LU)
5 GLU A 436
ALA A 440
ALA A 186
ALA A 156
ILE A 420
None
1.06A 4lbgB-1iwpA:
undetectable
4lbgB-1iwpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji0 ABC TRANSPORTER

(Thermotoga
maritima)
PF00005
(ABC_tran)
5 ALA A 222
VAL A 210
ALA A 198
ALA A 201
ILE A  37
None
1.10A 4lbgB-1ji0A:
undetectable
4lbgB-1ji0A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Sulfolobus
solfataricus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A  91
ILE A  30
VAL A 130
ALA A  35
ALA A  34
None
1.08A 4lbgB-1jvbA:
3.9
4lbgB-1jvbA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krq FERRITIN

(Campylobacter
jejuni)
PF00210
(Ferritin)
5 ALA A  39
ILE A 137
VAL A 138
ALA A 154
ILE A 141
None
1.10A 4lbgB-1krqA:
undetectable
4lbgB-1krqA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE


(Pyrococcus
horikoshii)
PF06026
(Rib_5-P_isom_A)
5 GLU A 196
ILE A 148
VAL A 203
ALA A 182
ILE A 138
None
1.07A 4lbgB-1lk5A:
3.3
4lbgB-1lk5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi1 SCML2 PROTEIN

(Homo sapiens)
PF02820
(MBT)
6 ALA A  47
ILE A 194
VAL A 202
ALA A 180
ALA A 192
ILE A 204
None
1.37A 4lbgB-1oi1A:
undetectable
4lbgB-1oi1A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE


(Zea mays)
PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C)
5 THR A 551
VAL A 618
ALA A 543
ALA A 541
ILE A 560
None
1.05A 4lbgB-1vbgA:
undetectable
4lbgB-1vbgA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE


(Thermus
thermophilus)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 ALA A 127
ILE A 135
VAL A 267
ALA A 257
ALA A 258
None
1.02A 4lbgB-1x1oA:
undetectable
4lbgB-1x1oA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE


(Chromobacterium
violaceum)
PF01869
(BcrAD_BadFG)
5 ILE A  14
VAL A  16
ALA A  38
ALA A  63
ILE A  25
None
1.08A 4lbgB-1zc6A:
undetectable
4lbgB-1zc6A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS


(Bacillus
subtilis)
PF02898
(NO_synthase)
5 ALA A 283
ILE A 198
VAL A 260
ALA A 276
ILE A 261
None
1.02A 4lbgB-2an2A:
undetectable
4lbgB-2an2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE


(Podophyllum
peltatum)
PF13561
(adh_short_C2)
6 GLU A 184
ILE A 190
VAL A 192
ALA A 133
ALA A 136
ILE A 148
None
1.41A 4lbgB-2bgkA:
7.1
4lbgB-2bgkA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN


(Aeropyrum
pernix)
no annotation 5 ALA A 137
VAL A 167
ALA A 157
ALA A 123
ILE A 159
None
1.01A 4lbgB-2cxhA:
undetectable
4lbgB-2cxhA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B


(Bacillus
subtilis)
PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB)
6 THR A 557
ALA A 563
ILE A 538
VAL A 549
ALA A 522
ILE A 519
None
1.35A 4lbgB-2d7dA:
undetectable
4lbgB-2d7dA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Sulfurisphaera
tokodaii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A  91
ILE A  30
VAL A 130
ALA A  35
ALA A  34
None
1.09A 4lbgB-2eerA:
3.8
4lbgB-2eerA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4l ACETAMIDASE,
PUTATIVE


(Thermotoga
maritima)
PF03069
(FmdA_AmdA)
5 GLU A 235
ILE A 277
ALA A 251
ALA A 255
ILE A 240
None
1.06A 4lbgB-2f4lA:
undetectable
4lbgB-2f4lA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE


(Methanopyrus
kandleri)
PF01913
(FTR)
PF02741
(FTR_C)
5 ILE A  75
VAL A  73
ALA A 103
CYH A  96
ILE A  25
None
None
K  A 711 (-4.2A)
None
None
1.02A 4lbgB-2fhkA:
undetectable
4lbgB-2fhkA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyw CONSERVED
HYPOTHETICAL PROTEIN


(Streptococcus
pneumoniae)
PF01784
(NIF3)
5 THR A 259
ILE A  93
VAL A  95
ALA A  42
ILE A  61
None
0.95A 4lbgB-2fywA:
undetectable
4lbgB-2fywA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Mycobacterium
tuberculosis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
6 ALA A 329
ILE A 305
VAL A 308
ALA A 411
ALA A 294
ILE A 399
None
1.42A 4lbgB-2gp6A:
undetectable
4lbgB-2gp6A:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iih MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C


(Thermus
thermophilus)
PF01967
(MoaC)
5 ALA A  30
ILE A 137
ALA A  56
CYH A 117
ALA A 120
None
0.95A 4lbgB-2iihA:
undetectable
4lbgB-2iihA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv0 ISOCITRATE
DEHYDROGENASE


(Archaeoglobus
fulgidus)
PF00180
(Iso_dh)
5 ALA A  68
ILE A 114
VAL A 328
ALA A  87
ILE A  88
None
1.10A 4lbgB-2iv0A:
2.4
4lbgB-2iv0A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2


(Homo sapiens)
PF00428
(Ribosomal_60s)
5 ALA B 105
ILE B 155
VAL B 154
ALA B 111
ILE B 151
None
1.04A 4lbgB-2lbfB:
undetectable
4lbgB-2lbfB:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides)
PF02614
(UxaC)
5 GLU A 170
VAL A 191
ALA A  48
ALA A 181
ILE A 182
None
1.03A 4lbgB-2q01A:
2.2
4lbgB-2q01A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT


(Murray Valley
encephalitis
virus)
PF00271
(Helicase_C)
PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B)
PF07652
(Flavi_DEAD)
5 ALA A  56
ILE A  58
ALA A  36
ALA A  27
ILE A  25
None
1.05A 4lbgB-2wv9A:
undetectable
4lbgB-2wv9A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE


(Nocardia
farcinica)
no annotation 5 ILE A 191
VAL A 203
ALA A 218
CYH A 194
ALA A 217
None
None
None
TRS  A 300 (-3.1A)
None
1.03A 4lbgB-2xecA:
undetectable
4lbgB-2xecA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE


(Bacillus
subtilis)
PF01008
(IF-2B)
5 ALA A 263
ILE A 266
VAL A 235
ALA A 223
ALA A 224
None
1.03A 4lbgB-2yrfA:
4.2
4lbgB-2yrfA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0j PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1438


(Thermus
thermophilus)
PF04029
(2-ph_phosp)
5 ALA A 159
ILE A 138
VAL A  22
ALA A 121
ALA A 125
None
1.00A 4lbgB-2z0jA:
undetectable
4lbgB-2z0jA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7e NIFU-LIKE PROTEIN

(Aquifex
aeolicus)
PF01592
(NifU_N)
5 ALA A  85
ILE A  53
VAL A  56
ALA A 118
ILE A  44
None
0.92A 4lbgB-2z7eA:
undetectable
4lbgB-2z7eA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbv UNCHARACTERIZED
CONSERVED PROTEIN


(Thermotoga
maritima)
PF01887
(SAM_adeno_trans)
5 ALA A  18
ILE A  31
ALA A 136
ALA A 137
ILE A   2
None
1.09A 4lbgB-2zbvA:
2.7
4lbgB-2zbvA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3l KETOHEXOKINASE

(Homo sapiens)
PF00294
(PfkB)
6 GLU A 227
ALA A 244
VAL A 250
ALA A 256
CYH A 282
ALA A 285
None
0.70A 4lbgB-3b3lA:
27.8
4lbgB-3b3lA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfj 1,3-PROPANEDIOL
OXIDOREDUCTASE


(Klebsiella
pneumoniae)
PF00465
(Fe-ADH)
6 ALA A 228
ILE A 224
VAL A 204
ALA A 327
ALA A 308
ILE A 307
None
1.26A 4lbgB-3bfjA:
3.3
4lbgB-3bfjA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III


(Homo sapiens)
PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28)
5 THR A 468
ALA A 572
ILE A 388
VAL A 384
ALA A 525
None
1.08A 4lbgB-3fedA:
undetectable
4lbgB-3fedA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvw PUTATIVE
NAD(P)H-DEPENDENT
FMN REDUCTASE


(Streptococcus
mutans)
PF03358
(FMN_red)
5 ALA A 175
ILE A  29
VAL A  35
ALA A  70
ILE A   5
None
1.07A 4lbgB-3fvwA:
undetectable
4lbgB-3fvwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE


(Leishmania
major)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 ALA A  98
VAL A  94
ALA A  58
ALA A  85
ILE A  89
None
1.06A 4lbgB-3g1uA:
4.8
4lbgB-3g1uA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbd CLASS IV CHITINASE
CHIA4-PA2


(Picea abies)
PF00182
(Glyco_hydro_19)
5 GLU A 102
ILE A  52
VAL A  49
CYH A 238
ILE A  53
None
1.08A 4lbgB-3hbdA:
undetectable
4lbgB-3hbdA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i10 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Bacteroides
thetaiotaomicron)
PF03009
(GDPD)
PF16387
(DUF4996)
5 GLU A 220
ALA A 218
ILE A 281
VAL A  44
ILE A  71
PEG  A  21 (-3.1A)
None
None
None
None
1.05A 4lbgB-3i10A:
2.1
4lbgB-3i10A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT


(Saccharomyces
cerevisiae)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
5 ALA A 533
ILE A 399
VAL A 397
ALA A 349
ILE A 317
None
1.10A 4lbgB-3iayA:
undetectable
4lbgB-3iayA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Herpetosiphon
aurantiacus)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A 183
ILE A 160
VAL A 162
ALA A 145
ILE A 137
None
0.95A 4lbgB-3ik4A:
undetectable
4lbgB-3ik4A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwr CHITINASE

(Oryza sativa)
PF00182
(Glyco_hydro_19)
5 THR A 247
ALA A 241
ALA A 218
ALA A 215
ILE A 219
None
1.11A 4lbgB-3iwrA:
undetectable
4lbgB-3iwrA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knz PUTATIVE SUGAR
BINDING PROTEIN


(Salmonella
enterica)
PF01380
(SIS)
5 ALA A 154
ILE A  34
VAL A  83
ALA A  22
ALA A  23
None
1.06A 4lbgB-3knzA:
2.9
4lbgB-3knzA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l51 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2


(Mus musculus)
PF06470
(SMC_hinge)
5 GLU A 542
ALA A 545
ILE A 530
VAL A 532
ALA A 606
None
1.06A 4lbgB-3l51A:
undetectable
4lbgB-3l51A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhx KETODEOXYGLUCONOKINA
SE


(Shigella
flexneri)
PF00294
(PfkB)
5 ALA A 321
VAL A 329
ALA A 335
ALA A 364
ILE A 368
None
0.54A 4lbgB-3lhxA:
30.4
4lbgB-3lhxA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwg HP0420 HOMOLOGUE

(Helicobacter
felis)
no annotation 5 ILE A 126
ALA A  96
CYH A  66
ALA A  67
ILE A 108
None
1.09A 4lbgB-3lwgA:
undetectable
4lbgB-3lwgA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otx ADENOSINE KINASE,
PUTATIVE


(Trypanosoma
brucei)
PF00294
(PfkB)
5 THR A 264
VAL A 291
ALA A 297
ALA A 326
ILE A 330
AP5  A 346 (-3.6A)
AP5  A 346 ( 4.9A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.0A)
AP5  A 346 (-4.9A)
0.49A 4lbgB-3otxA:
39.6
4lbgB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9t REPRESSOR

(Stenotrophomonas
maltophilia)
PF00440
(TetR_N)
PF08361
(TetR_C_2)
5 ALA A  39
ILE A  37
ALA A  11
ALA A  47
ILE A  16
None
1.08A 4lbgB-3p9tA:
undetectable
4lbgB-3p9tA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9x PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE


(Bacillus
halodurans)
PF00551
(Formyl_trans_N)
5 GLU A  16
VAL A  31
ALA A   8
ALA A  87
ILE A   6
None
1.06A 4lbgB-3p9xA:
4.6
4lbgB-3p9xA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdf 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE


(Mycobacterium
marinum)
PF01557
(FAA_hydrolase)
PF10370
(DUF2437)
5 THR A  43
VAL A  52
ALA A  15
ALA A  13
ILE A   6
None
1.10A 4lbgB-3qdfA:
undetectable
4lbgB-3qdfA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rqi RESPONSE REGULATOR
PROTEIN


(Burkholderia
pseudomallei)
PF00072
(Response_reg)
PF02954
(HTH_8)
5 ALA A  43
ILE A  51
VAL A  53
ALA A  33
ILE A   9
None
None
PHD  A  54 ( 3.1A)
None
None
1.01A 4lbgB-3rqiA:
5.4
4lbgB-3rqiA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7c CARVEOL
DEHYDROGENASE


(Mycobacterium
avium)
PF13561
(adh_short_C2)
5 GLU A 187
ILE A 193
VAL A 195
ALA A 136
ILE A 152
None
1.05A 4lbgB-3t7cA:
6.4
4lbgB-3t7cA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Coxiella
burnetii)
PF00275
(EPSP_synthase)
5 THR A 397
ALA A 422
ILE A  15
ALA A 244
ILE A 252
None
1.03A 4lbgB-3tr1A:
undetectable
4lbgB-3tr1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9i MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN


(Roseiflexus sp.
RS-1)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A 190
ILE A 166
ALA A 152
ALA A 153
ILE A 141
None
0.99A 4lbgB-3u9iA:
undetectable
4lbgB-3u9iA:
27.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti)
PF00294
(PfkB)
7 THR A 245
GLU A 248
ALA A 264
VAL A 270
ALA A 276
ALA A 305
ILE A 309
ADP  A 354 (-3.3A)
ADP  A 354 (-4.9A)
ADP  A 354 ( 4.0A)
None
ADP  A 354 (-3.4A)
ADP  A 354 (-2.7A)
None
0.45A 4lbgB-3uboA:
57.0
4lbgB-3uboA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrk CARBONYL SULFIDE
HYDROLASE


(Thiobacillus
thioparus)
PF00484
(Pro_CA)
6 ALA A  76
ILE A 178
VAL A 194
ALA A  40
CYH A  79
ILE A  92
None
1.18A 4lbgB-3vrkA:
undetectable
4lbgB-3vrkA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB


(Pseudomonas
aeruginosa)
PF00873
(ACR_tran)
5 ALA A 651
VAL A 606
ALA A 627
ALA A 574
ILE A 629
None
1.11A 4lbgB-3w9iA:
undetectable
4lbgB-3w9iA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Streptococcus
pneumoniae)
PF00275
(EPSP_synthase)
5 ALA A 175
ILE A 184
ALA A 132
ALA A 156
ILE A 158
None
0.99A 4lbgB-3zh4A:
undetectable
4lbgB-3zh4A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE


(Mycobacterium
tuberculosis)
PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C)
5 ALA A 329
ILE A 350
VAL A 386
ALA A 335
ALA A 334
None
1.06A 4lbgB-3zhyA:
5.9
4lbgB-3zhyA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA


(Mycobacterium
tuberculosis)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ALA C 284
VAL C 267
ALA C 103
ALA C   5
ILE C 269
None
0.91A 4lbgB-4b3iC:
undetectable
4lbgB-4b3iC:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmv SHORT-CHAIN
DEHYDROGENASE


(Sphingobium
yanoikuyae)
PF00106
(adh_short)
5 GLU A 170
ILE A 176
VAL A 178
ALA A 120
ILE A 135
None
1.03A 4lbgB-4bmvA:
6.7
4lbgB-4bmvA:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli)
PF00294
(PfkB)
9 THR A 243
GLU A 246
ALA A 262
ILE A 265
VAL A 268
ALA A 274
CYH A 300
ALA A 303
ILE A 307
None
0.42A 4lbgB-4e3aA:
62.6
4lbgB-4e3aA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e84 D-BETA-D-HEPTOSE
7-PHOSPHATE KINASE


(Burkholderia
cenocepacia)
PF00294
(PfkB)
5 THR A 238
GLU A 241
ALA A 257
ALA A 268
ALA A 297
ANP  A 501 (-3.8A)
None
ANP  A 501 ( 3.7A)
ANP  A 501 (-3.5A)
ANP  A 501 (-3.7A)
0.53A 4lbgB-4e84A:
27.3
4lbgB-4e84A:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e84 D-BETA-D-HEPTOSE
7-PHOSPHATE KINASE


(Burkholderia
cenocepacia)
PF00294
(PfkB)
5 THR A 238
GLU A 241
VAL A 262
ALA A 268
ALA A 297
ANP  A 501 (-3.8A)
None
ANP  A 501 (-4.4A)
ANP  A 501 (-3.5A)
ANP  A 501 (-3.7A)
0.64A 4lbgB-4e84A:
27.3
4lbgB-4e84A:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 THR A 206
ILE A 235
VAL A 152
ALA A 184
ILE A 157
None
1.05A 4lbgB-4ej6A:
3.9
4lbgB-4ej6A:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gic HISTIDINOL
DEHYDROGENASE


(Methylococcus
capsulatus)
PF00815
(Histidinol_dh)
5 ALA A 273
ILE A   6
VAL A   4
ALA A 258
ILE A 290
None
1.04A 4lbgB-4gicA:
3.0
4lbgB-4gicA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h14 SPIKE GLYCOPROTEIN

(Betacoronavirus
1)
PF16451
(Spike_NTD)
5 THR A 230
ALA A 105
ILE A 125
VAL A 140
ALA A 221
None
1.06A 4lbgB-4h14A:
undetectable
4lbgB-4h14A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Xanthobacter
autotrophicus)
PF13561
(adh_short_C2)
5 ALA A  32
ILE A 231
VAL A 230
ALA A  24
ILE A  23
None
1.07A 4lbgB-4ituA:
3.9
4lbgB-4ituA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 ACETALDEHYDE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer)
5 ALA B 119
ILE B 292
VAL B 288
ALA B  95
ILE B  96
None
0.99A 4lbgB-4jn6B:
5.8
4lbgB-4jn6B:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jwv SHORT CHAIN
ENOYL-COA HYDRATASE


(Novosphingobium
aromaticivorans)
PF00378
(ECH_1)
5 VAL A 176
ALA A  99
CYH A 115
ALA A 116
ILE A 119
None
0.95A 4lbgB-4jwvA:
undetectable
4lbgB-4jwvA:
30.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldz TRANSCRIPTIONAL
REGULATORY PROTEIN
DESR


(Bacillus
subtilis)
PF00072
(Response_reg)
PF00196
(GerE)
5 GLU A  67
ALA A  65
ILE A  76
VAL A  96
ILE A  78
None
1.07A 4lbgB-4ldzA:
4.8
4lbgB-4ldzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxy ACYL-COA SYNTHETASE

(Streptomyces
lividans)
PF00583
(Acetyltransf_1)
5 ALA A 122
VAL A 103
ALA A 146
ALA A 149
ILE A 145
None
1.10A 4lbgB-4nxyA:
undetectable
4lbgB-4nxyA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3s DNA POLYMERASE ETA

(Homo sapiens)
PF00817
(IMS)
PF11799
(IMS_C)
5 ALA A  54
ALA A  65
CYH A  72
ALA A  68
ILE A  47
None
0.99A 4lbgB-4o3sA:
undetectable
4lbgB-4o3sA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo0 MAF-LIKE PROTEIN
BCAL2394


(Burkholderia
cenocepacia)
PF02545
(Maf)
5 ILE A 189
VAL A 150
ALA A 182
ALA A 183
ILE A 186
None
1.04A 4lbgB-4oo0A:
undetectable
4lbgB-4oo0A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE


(Pseudomonas
fluorescens)
PF00171
(Aldedh)
5 ALA A 274
ILE A 451
VAL A 447
ALA A 435
ILE A 436
None
0.99A 4lbgB-4ou2A:
3.4
4lbgB-4ou2A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfb CT263

(Chlamydia
trachomatis)
no annotation 5 THR A  17
ALA A 185
ILE A 109
ALA A  70
ILE A  68
None
0.96A 4lbgB-4qfbA:
undetectable
4lbgB-4qfbA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r81 NADH DEHYDROGENASE

(Methanothermobacter
marburgensis)
PF02525
(Flavodoxin_2)
5 ILE A 122
VAL A 163
ALA A  81
ALA A  79
ILE A 124
None
0.98A 4lbgB-4r81A:
undetectable
4lbgB-4r81A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1


(Nitrosomonas
europaea)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
5 ALA A 591
ILE A 655
VAL A 657
ALA A 709
ALA A 713
None
1.09A 4lbgB-4rbnA:
3.1
4lbgB-4rbnA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR


(Mycolicibacterium
smegmatis)
PF13407
(Peripla_BP_4)
5 GLU A 341
ALA A 339
ALA A 276
ALA A 277
ILE A 329
None
1.10A 4lbgB-4rsmA:
4.1
4lbgB-4rsmA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR


(Verminephrobacter
eiseniae)
PF13407
(Peripla_BP_4)
5 ALA A 163
ILE A 253
ALA A 244
ALA A 241
ILE A 245
None
1.01A 4lbgB-4ry9A:
6.0
4lbgB-4ry9A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE


(Legionella
pneumophila)
PF00282
(Pyridoxal_deC)
5 ALA A 258
ILE A 245
VAL A 293
ALA A 230
ALA A 229
None
1.10A 4lbgB-4w8iA:
3.5
4lbgB-4w8iA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wji PUTATIVE
CYCLOHEXADIENYL
DEHYDROGENASE AND
ADH PREPHENATE
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF02153
(PDH)
5 ALA A  66
VAL A  71
ALA A  59
ALA A  62
ILE A  11
None
1.07A 4lbgB-4wjiA:
4.2
4lbgB-4wjiA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)


(Agrobacterium
vitis)
PF13407
(Peripla_BP_4)
5 ALA A  99
ILE A  86
VAL A  83
ALA A 106
ILE A 108
None
1.09A 4lbgB-4wutA:
5.5
4lbgB-4wutA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Rhodobacter
sphaeroides)
PF03480
(DctP)
5 GLU A 207
ILE A 203
VAL A 194
ALA A 222
ILE A 198
None
0.91A 4lbgB-4x8rA:
undetectable
4lbgB-4x8rA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE


(Streptomyces
hygroscopicus)
no annotation 5 ALA A 312
ILE A 292
VAL A 294
ALA A 262
ILE A 335
None
0.90A 4lbgB-5a3kA:
undetectable
4lbgB-5a3kA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE


(Streptomyces
platensis)
PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C)
5 ALA A 417
ILE A 385
ALA A 316
ALA A 363
ILE A 360
None
1.00A 4lbgB-5bp8A:
undetectable
4lbgB-5bp8A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1)
PF00296
(Bac_luciferase)
5 GLU A 246
ALA A 250
VAL A 263
ALA A 223
ILE A 230
None
0.97A 4lbgB-5dqpA:
undetectable
4lbgB-5dqpA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnd PUTATIVE SERINE
PROTEASE HHOA


(Synechocystis
sp. PCC 6803)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
5 ALA A 265
ILE A 249
VAL A 248
ALA A 271
ILE A 268
None
1.06A 4lbgB-5gndA:
undetectable
4lbgB-5gndA:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN


(Klebsiella
pneumoniae)
PF13407
(Peripla_BP_4)
5 GLU A 237
ILE A 245
VAL A 247
ALA A 208
ILE A 221
None
1.10A 4lbgB-5hsgA:
4.6
4lbgB-5hsgA:
30.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huo NICOTINATE-NUCLEOTID
E DIPHOSPHORYLASE
(CARBOXYLATING)


(Streptococcus
pyogenes)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 ALA A 233
ILE A 243
ALA A 212
ALA A 213
ILE A 220
None
1.08A 4lbgB-5huoA:
undetectable
4lbgB-5huoA:
29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im5 DESIGNED
KETO-HYDROXYGLUTARAT
E-ALDOLASE/KETO-DEOX
Y-PHOSPHOGLUCONATE
ALDOLASE


(Vibrionales
bacterium
SWAT-3)
no annotation 5 THR P  69
ALA P  49
ILE P  25
ALA P  18
ILE P  17
None
1.10A 4lbgB-5im5P:
undetectable
4lbgB-5im5P:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE


(Bacillus
anthracis)
PF04127
(DFP)
5 ILE A 271
VAL A 269
ALA A 228
ALA A 223
ILE A 190
None
1.04A 4lbgB-5intA:
5.2
4lbgB-5intA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE


(Leishmania
major)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 ALA A 151
ILE A 178
ALA A 251
ALA A 252
ILE A 173
None
1.10A 4lbgB-5l16A:
undetectable
4lbgB-5l16A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unl 3-KETOACYL-ACP
REDUCTASE


(Burkholderia
multivorans)
PF13561
(adh_short_C2)
5 GLU A 178
ILE A 184
VAL A 186
ALA A 130
ILE A 143
None
1.06A 4lbgB-5unlA:
5.9
4lbgB-5unlA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1


(Streptococcus
pneumoniae)
PF00275
(EPSP_synthase)
5 ALA A 177
ILE A 186
ALA A 136
ALA A 158
ILE A 160
None
0.96A 4lbgB-5wi5A:
undetectable
4lbgB-5wi5A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydp TETR TRANSCRIPTIONAL
REGULATORY PROTEIN


(Dietzia sp.
DQ12-45-1b)
PF00440
(TetR_N)
5 ALA A 159
ILE A  93
ALA A 175
ALA A 176
ILE A 179
None
0.94A 4lbgB-5ydpA:
undetectable
4lbgB-5ydpA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Pseudomonas
putida)
no annotation 5 ALA A 346
ILE A 319
VAL A 247
ALA A 383
ALA A 386
None
1.07A 4lbgB-6cn1A:
undetectable
4lbgB-6cn1A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k POLYSULPHIDE
REDUCTASE NRFD


(Rhodothermus
marinus)
no annotation 5 ALA C 290
ILE C 300
ALA C 121
ALA C 120
ILE C 117
None
1.03A 4lbgB-6f0kC:
undetectable
4lbgB-6f0kC:
14.38