SIMILAR PATTERNS OF AMINO ACIDS FOR 4LBG_B_ADNB401_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a27 | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE (Homo sapiens) |
PF00106(adh_short) | 3 | SER A 222TYR A 218PRO A 187 | NoneNoneEST A 350 (-4.1A) | 0.91A | 4lbgB-1a27A:5.8 | 4lbgB-1a27A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1am5 | PEPSIN (Gadus morhua) |
PF00026(Asp) | 3 | SER A 35TYR A 75PRO A 135 | None | 0.84A | 4lbgB-1am5A:undetectable | 4lbgB-1am5A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b5f | PROTEIN (CARDOSIN A) (Cynaracardunculus) |
PF00026(Asp) | 3 | SER A 35TYR A 75PRO A 135 | None | 0.87A | 4lbgB-1b5fA:undetectable | 4lbgB-1b5fA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b74 | GLUTAMATE RACEMASE (Aquifexpyrophilus) |
PF01177(Asp_Glu_race) | 3 | SER A 205TYR A 23PRO A 95 | None | 0.61A | 4lbgB-1b74A:3.7 | 4lbgB-1b74A:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1czi | CHYMOSIN (Bos taurus) |
PF00026(Asp) | 3 | SER E 35TYR E 75PRO E 135 | None | 0.72A | 4lbgB-1cziE:undetectable | 4lbgB-1cziE:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dgp | ARISTOLOCHENESYNTHASE (Penicilliumroqueforti) |
no annotation | 3 | SER A 210TYR A 319PRO A 174 | None | 0.94A | 4lbgB-1dgpA:undetectable | 4lbgB-1dgpA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fdw | 17-BETA-HYDROXYSTEROID DEHYDROGENASE (Homo sapiens) |
PF00106(adh_short) | 3 | SER A 222TYR A 218PRO A 187 | EST A 350 (-4.4A)NoneEST A 350 (-4.3A) | 0.87A | 4lbgB-1fdwA:6.3 | 4lbgB-1fdwA:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz5 | ALPHA-TREHALOSE-PHOSPHATE SYNTHASE (Escherichiacoli) |
PF00982(Glyco_transf_20) | 3 | SER A 80TYR A 105PRO A 86 | None | 0.74A | 4lbgB-1gz5A:4.8 | 4lbgB-1gz5A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz5 | ALPHA-TREHALOSE-PHOSPHATE SYNTHASE (Escherichiacoli) |
PF00982(Glyco_transf_20) | 3 | SER A 266TYR A 265PRO A 156 | None | 0.96A | 4lbgB-1gz5A:4.8 | 4lbgB-1gz5A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nt4 | GLUCOSE-1-PHOSPHATASE (Escherichiacoli) |
PF00328(His_Phos_2) | 3 | SER A 208TYR A 247PRO A 23 | None | 0.86A | 4lbgB-1nt4A:undetectable | 4lbgB-1nt4A:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q0p | COMPLEMENT FACTOR B (Homo sapiens) |
PF00092(VWA) | 3 | SER A 342TYR A 338PRO A 349 | None | 0.78A | 4lbgB-1q0pA:undetectable | 4lbgB-1q0pA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q0z | ACLACINOMYCINMETHYLESTERASE (Streptomycespurpurascens) |
PF00561(Abhydrolase_1) | 3 | SER A 187TYR A 198PRO A 249 | None1PE A2712 (-4.2A)None | 0.85A | 4lbgB-1q0zA:3.8 | 4lbgB-1q0zA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qrp | PEPSIN 3A (Homo sapiens) |
PF00026(Asp) | 3 | SER E 35TYR E 75PRO E 135 | HH0 E 327 (-4.1A)HH0 E 327 (-4.5A)None | 0.79A | 4lbgB-1qrpE:undetectable | 4lbgB-1qrpE:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rpw | TRANSCRIPTIONALREGULATOR QACR (Staphylococcusaureus) |
PF00440(TetR_N)PF08360(TetR_C_5) | 3 | SER A 86TYR A 82PRO A 94 | None | 0.69A | 4lbgB-1rpwA:undetectable | 4lbgB-1rpwA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1smr | RENIN (Mus musculus) |
PF00026(Asp) | 3 | SER A 35TYR A 75PRO A 135 | None | 0.83A | 4lbgB-1smrA:undetectable | 4lbgB-1smrA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sp3 | CYTOCHROME C,PUTATIVE (Shewanellaoneidensis) |
PF11783(Cytochrome_cB)PF13435(Cytochrome_C554) | 3 | SER A 159TYR A 145PRO A 164 | None | 0.97A | 4lbgB-1sp3A:undetectable | 4lbgB-1sp3A:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tzs | CATHEPSIN E (Homo sapiens) |
PF00026(Asp) | 3 | SER A 46TYR A 86PRO A 146 | None | 0.68A | 4lbgB-1tzsA:undetectable | 4lbgB-1tzsA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vq0 | 33 KDA CHAPERONIN (Thermotogamaritima) |
PF01430(HSP33) | 3 | SER A 127TYR A 143PRO A 124 | None | 0.88A | 4lbgB-1vq0A:undetectable | 4lbgB-1vq0A:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wao | SERINE/THREONINEPROTEIN PHOSPHATASE5 (Homo sapiens) |
PF00149(Metallophos)PF00515(TPR_1)PF08321(PPP5) | 3 | SER 1 277TYR 1 489PRO 1 482 | None | 0.94A | 4lbgB-1wao1:undetectable | 4lbgB-1wao1:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wz2 | LEUCYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1) | 3 | SER A 46TYR A 109PRO A 43 | None | 0.86A | 4lbgB-1wz2A:undetectable | 4lbgB-1wz2A:15.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ydm | HYPOTHETICAL PROTEINYQGN (Bacillussubtilis) |
PF01812(5-FTHF_cyc-lig) | 3 | SER A 49TYR A 97PRO A 122 | None | 0.64A | 4lbgB-1ydmA:2.8 | 4lbgB-1ydmA:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aey | FRUCTAN1-EXOHYDROLASE IIA (Cichoriumintybus) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 3 | SER A 276TYR A 268PRO A 26 | None | 0.86A | 4lbgB-2aeyA:undetectable | 4lbgB-2aeyA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b71 | CYCLOPHILIN-LIKEPROTEIN (Plasmodiumyoelii) |
PF00160(Pro_isomerase) | 3 | SER A 136TYR A 108PRO A 94 | None | 0.95A | 4lbgB-2b71A:undetectable | 4lbgB-2b71A:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c0l | NONSPECIFICLIPID-TRANSFERPROTEINPEROXISOMALTARGETING SIGNAL 1RECEPTOR (Homo sapiens) |
PF00515(TPR_1)PF02036(SCP2)PF13432(TPR_16) | 3 | SER A 565TYR A 545PRO B 138 | None | 0.95A | 4lbgB-2c0lA:undetectable | 4lbgB-2c0lA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d4e | 5-CARBOXYMETHYL-2-HYDROXYMUCONATESEMIALDEHYDEDEHYDROGENASE (Thermusthermophilus) |
PF00171(Aldedh) | 3 | SER A 481TYR A 435PRO A 270 | None | 0.91A | 4lbgB-2d4eA:3.3 | 4lbgB-2d4eA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g1s | RENIN (Homo sapiens) |
PF00026(Asp) | 3 | SER A 36TYR A 78PRO A 137 | 4IG A 885 ( 4.8A)4IG A 885 (-4.0A)None | 0.84A | 4lbgB-2g1sA:undetectable | 4lbgB-2g1sA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gb3 | ASPARTATEAMINOTRANSFERASE (Thermotogamaritima) |
PF00155(Aminotran_1_2) | 3 | SER A 215TYR A 80PRO A 171 | None | 0.94A | 4lbgB-2gb3A:2.9 | 4lbgB-2gb3A:24.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lsn | RNASE H (Simian foamyvirus) |
PF00075(RNase_H) | 3 | SER A 90TYR A 86PRO A 96 | None | 0.86A | 4lbgB-2lsnA:undetectable | 4lbgB-2lsnA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nzx | ALPHA1,3-FUCOSYLTRANSFERASE (Helicobacterpylori) |
PF00852(Glyco_transf_10) | 3 | SER A 52TYR A 48PRO A 24 | None | 0.96A | 4lbgB-2nzxA:undetectable | 4lbgB-2nzxA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qt6 | LACCASE (Lentinustigrinus) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 3 | SER A 202TYR A 209PRO A 123 | None | 0.95A | 4lbgB-2qt6A:undetectable | 4lbgB-2qt6A:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x5d | PROBABLEAMINOTRANSFERASE (Pseudomonasaeruginosa) |
PF00155(Aminotran_1_2) | 3 | SER A 225TYR A 87PRO A 180 | None | 0.85A | 4lbgB-2x5dA:2.2 | 4lbgB-2x5dA:24.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xwb | COMPLEMENT FACTOR B (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin)PF00092(VWA) | 3 | SER F 342TYR F 338PRO F 349 | None | 0.87A | 4lbgB-2xwbF:undetectable | 4lbgB-2xwbF:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zgi | PUTATIVE4-AMINO-4-DEOXYCHORISMATE LYASE (Thermusthermophilus) |
PF01063(Aminotran_4) | 3 | SER A 161TYR A 130PRO A 165 | None | 0.95A | 4lbgB-2zgiA:undetectable | 4lbgB-2zgiA:24.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ajb | PEROXISOMALBIOGENESIS FACTOR 3 (Homo sapiens) |
PF04882(Peroxin-3) | 3 | SER A 167TYR A 164PRO A 240 | None | 0.97A | 4lbgB-3ajbA:undetectable | 4lbgB-3ajbA:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3asa | LL-DIAMINOPIMELATEAMINOTRANSFERASE (Chlamydiatrachomatis) |
PF00155(Aminotran_1_2) | 3 | SER A 217TYR A 89PRO A 172 | None | 0.76A | 4lbgB-3asaA:undetectable | 4lbgB-3asaA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bga | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 3 | SER A 480TYR A 509PRO A 415 | None | 0.91A | 4lbgB-3bgaA:undetectable | 4lbgB-3bgaA:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctp | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Alkaliphilusmetalliredigens) |
PF13377(Peripla_BP_3) | 3 | SER A 125TYR A 131PRO A 68 | None | 0.97A | 4lbgB-3ctpA:2.4 | 4lbgB-3ctpA:23.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dec | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 3 | SER A 456TYR A 485PRO A 391 | None | 0.90A | 4lbgB-3decA:undetectable | 4lbgB-3decA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eh2 | PROTEIN TRANSPORTPROTEIN SEC24C (Homo sapiens) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 3 | SER A 488TYR A 486PRO A 208 | None | 0.76A | 4lbgB-3eh2A:2.8 | 4lbgB-3eh2A:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gm8 | GLYCOSIDE HYDROLASEFAMILY 2, CANDIDATEBETA-GLYCOSIDASE (Bacteroidesvulgatus) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 3 | SER A 130TYR A 182PRO A 346 | None | 0.97A | 4lbgB-3gm8A:2.0 | 4lbgB-3gm8A:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iiu | PERIDININ-CHLOROPHYLL A-BINDING PROTEIN1, CHLOROPLASTIC (Amphidiniumcarterae) |
PF02429(PCP) | 3 | SER M 112TYR M 108PRO M 32 | J7Z M 615 (-3.6A)PID M 613 ( 3.4A)J7Z M 615 ( 4.5A) | 0.88A | 4lbgB-3iiuM:undetectable | 4lbgB-3iiuM:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lso | PUTATIVE MEMBRANEANCHORED PROTEIN (Corynebacteriumdiphtheriae) |
PF16640(Big_3_5) | 3 | SER B 381TYR B 379PRO B 393 | None | 0.93A | 4lbgB-3lsoB:undetectable | 4lbgB-3lsoB:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mru | AMINOACYL-HISTIDINEDIPEPTIDASE (Vibrioalginolyticus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 3 | SER A 174TYR A 181PRO A 460 | None | 0.88A | 4lbgB-3mruA:undetectable | 4lbgB-3mruA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ntl | ACIDGLUCOSE-1-PHOSPHATEPHOSPHATASE (Enterobactercloacae) |
PF00328(His_Phos_2) | 3 | SER A 206TYR A 245PRO A 21 | NoneIHP A 550 (-4.8A)None | 0.94A | 4lbgB-3ntlA:undetectable | 4lbgB-3ntlA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ohn | OUTER MEMBRANE USHERPROTEIN FIMD (Escherichiacoli) |
PF00577(Usher) | 3 | SER A 296TYR A 222PRO A 254 | None | 0.88A | 4lbgB-3ohnA:undetectable | 4lbgB-3ohnA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psg | PEPSINOGEN (Sus scrofa) |
PF00026(Asp)PF07966(A1_Propeptide) | 3 | SER A 35TYR A 75PRO A 135 | None | 0.66A | 4lbgB-3psgA:undetectable | 4lbgB-3psgA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qtg | PYRUVATE KINASE (Pyrobaculumaerophilum) |
PF00224(PK)PF02887(PK_C) | 3 | SER A 411TYR A 199PRO A 420 | None | 0.87A | 4lbgB-3qtgA:3.7 | 4lbgB-3qtgA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qxf | ENDOGLUCANASE (Escherichiacoli) |
PF01270(Glyco_hydro_8) | 3 | SER A 115TYR A 182PRO A 94 | None | 0.73A | 4lbgB-3qxfA:undetectable | 4lbgB-3qxfA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sgg | HYPOTHETICALHYDROLASE (Bacteroidesthetaiotaomicron) |
PF14323(GxGYxYP_C)PF16216(GxGYxYP_N) | 3 | SER A 285TYR A 408PRO A 288 | None | 0.90A | 4lbgB-3sggA:undetectable | 4lbgB-3sggA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ti7 | BASIC EXTRACELLULARSUBTILISIN-LIKEPROTEASE BPRV (Dichelobacternodosus) |
PF00082(Peptidase_S8) | 3 | SER A 7TYR A 270PRO A 3 | None | 0.95A | 4lbgB-3ti7A:4.5 | 4lbgB-3ti7A:24.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 3 | SER A 60TYR A 158PRO A 314 | ADN A 353 (-4.6A)ADN A 353 (-3.6A)ADN A 353 (-4.2A) | 0.12A | 4lbgB-3uboA:57.0 | 4lbgB-3uboA:71.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ujq | LEGUME LECTIN (Lablabpurpureus) |
PF00139(Lectin_legB) | 3 | SER A 138TYR A 136PRO A 224 | None | 0.78A | 4lbgB-3ujqA:undetectable | 4lbgB-3ujqA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ako | SPORE COAT PROTEIN A (Bacillussubtilis) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 3 | SER A 459TYR A 300PRO A 456 | EDO A1517 ( 3.8A)NoneNone | 0.65A | 4lbgB-4akoA:undetectable | 4lbgB-4akoA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c4v | OUTER MEMBRANEPROTEIN ASSEMBLYFACTOR BAMA (Escherichiacoli) |
PF01103(Bac_surface_Ag)PF07244(POTRA) | 3 | SER A 591TYR A 578PRO A 587 | None | 0.90A | 4lbgB-4c4vA:undetectable | 4lbgB-4c4vA:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ccd | GALACTOCEREBROSIDASE (Mus musculus) |
PF02057(Glyco_hydro_59)PF17387(Glyco_hydro_59M) | 3 | SER A 316TYR A 58PRO A 471 | None | 0.89A | 4lbgB-4ccdA:undetectable | 4lbgB-4ccdA:19.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4e3a | SUGAR KINASE PROTEIN (Rhizobium etli) |
PF00294(PfkB) | 3 | SER A 58TYR A 156PRO A 312 | ADN A 500 (-3.3A)ADN A 500 (-3.8A)ADN A 500 (-4.3A) | 0.57A | 4lbgB-4e3aA:62.6 | 4lbgB-4e3aA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f5x | RNA-DIRECTED RNAPOLYMERASE (Rotavirus A) |
PF02123(RdRP_4)PF12289(Rotavirus_VP1) | 3 | SER W 671TYR W 518PRO W 281 | None | 0.85A | 4lbgB-4f5xW:undetectable | 4lbgB-4f5xW:16.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fl0 | AMINOTRANSFERASEALD1 (Arabidopsisthaliana) |
PF00155(Aminotran_1_2) | 3 | SER A 265TYR A 126PRO A 221 | None | 0.81A | 4lbgB-4fl0A:undetectable | 4lbgB-4fl0A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ikv | DI-TRIPEPTIDE ABCTRANSPORTER(PERMEASE) (Geobacilluskaustophilus) |
PF00854(PTR2) | 3 | SER A 405TYR A 406PRO A 388 | None | 0.96A | 4lbgB-4ikvA:undetectable | 4lbgB-4ikvA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4inf | METAL-DEPENDENTHYDROLASE (Novosphingobiumaromaticivorans) |
PF04909(Amidohydro_2) | 3 | SER A 159TYR A 165PRO A 92 | None | 0.97A | 4lbgB-4infA:undetectable | 4lbgB-4infA:28.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k3c | OUTER MEMBRANEPROTEIN ASSEMBLYFACTOR BAMA ([Haemophilus]ducreyi) |
PF01103(Bac_surface_Ag)PF07244(POTRA) | 3 | SER A 590TYR A 577PRO A 586 | None | 0.91A | 4lbgB-4k3cA:undetectable | 4lbgB-4k3cA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n75 | OUTER MEMBRANEPROTEIN ASSEMBLYFACTOR BAMA (Escherichiacoli) |
PF01103(Bac_surface_Ag) | 3 | SER A 591TYR A 578PRO A 587 | None | 0.90A | 4lbgB-4n75A:undetectable | 4lbgB-4n75A:24.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nsx | U3 SMALL NUCLEOLARRNA-ASSOCIATEDPROTEIN 21 (Saccharomycescerevisiae) |
PF00400(WD40)PF12894(ANAPC4_WD40) | 3 | SER A 350TYR A 295PRO A 353 | None | 0.76A | 4lbgB-4nsxA:undetectable | 4lbgB-4nsxA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oan | TRAP DICARBOXYLATETRANSPORTER DCTPSUBUNIT (Rhodopseudomonaspalustris) |
PF03480(DctP) | 3 | SER A 224TYR A 229PRO A 43 | None | 0.91A | 4lbgB-4oanA:undetectable | 4lbgB-4oanA:28.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oo2 | CHLOROPHENOL-4-MONOOXYGENASE (Streptomycesglobisporus) |
PF03241(HpaB)PF11794(HpaB_N) | 3 | SER A 126TYR A 123PRO A 374 | None | 0.91A | 4lbgB-4oo2A:undetectable | 4lbgB-4oo2A:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2b | ENDO-1,4-BETA-D-GLUCANASE (Pseudomonasputida) |
PF01270(Glyco_hydro_8) | 3 | SER A 115TYR A 182PRO A 94 | None | 0.90A | 4lbgB-4q2bA:undetectable | 4lbgB-4q2bA:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4quk | DIHYDROFLAVONOL-4-REDUCTASE (Medicagotruncatula) |
PF01370(Epimerase) | 3 | SER A 261TYR A 286PRO A 277 | None | 0.93A | 4lbgB-4qukA:6.1 | 4lbgB-4qukA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v15 | D-THREONINE ALDOLASE (Achromobacterxylosoxidans) |
PF01168(Ala_racemase_N)PF14031(D-ser_dehydrat) | 3 | SER A 252TYR A 260PRO A 56 | PLP A1381 (-2.6A)PLP A1380 (-4.4A)None | 0.85A | 4lbgB-4v15A:undetectable | 4lbgB-4v15A:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wxp | NS3-4 PROTEASE (Hepacivirus C) |
PF07652(Flavi_DEAD) | 3 | SER A 294TYR A 270PRO A 326 | None | 0.77A | 4lbgB-4wxpA:undetectable | 4lbgB-4wxpA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y7p | ALKALINE D-PEPTIDASE (Bacillus cereus) |
PF00144(Beta-lactamase) | 3 | SER A 215TYR A 240PRO A 211 | None | 0.83A | 4lbgB-4y7pA:undetectable | 4lbgB-4y7pA:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yu9 | GLUTAMINYL-PEPTIDECYCLOTRANSFERASE (Homo sapiens) |
PF04389(Peptidase_M28) | 3 | SER A 323TYR A 299PRO A 326 | None | 0.90A | 4lbgB-4yu9A:undetectable | 4lbgB-4yu9A:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z6k | ALCOHOLDEHYDROGENASE (Moraxella sp.TAE123) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | SER A 295TYR A 183PRO A 135 | None | 0.96A | 4lbgB-4z6kA:5.2 | 4lbgB-4z6kA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eqv | BIFUNCTIONAL2',3'-CYCLICNUCLEOTIDE2'-PHOSPHODIESTERASE/3'-NUCLEOTIDASEPERIPLASMICPRECURSOR PROTEIN (Yersinia pestis) |
PF00149(Metallophos) | 3 | SER A 248TYR A 241PRO A 232 | NonePGE A 407 (-3.5A)None | 0.97A | 4lbgB-5eqvA:undetectable | 4lbgB-5eqvA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hjr | NEUTRALALPHA-GLUCOSIDASE AB (Mus musculus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 3 | SER A 530TYR A 511PRO A 526 | None | 0.96A | 4lbgB-5hjrA:undetectable | 4lbgB-5hjrA:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5huu | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE[UDP-FORMING] (Candidaalbicans) |
PF00982(Glyco_transf_20) | 3 | SER A 93TYR A 118PRO A 99 | None | 0.67A | 4lbgB-5huuA:4.4 | 4lbgB-5huuA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hvm | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) (Aspergillusfumigatus) |
PF00982(Glyco_transf_20) | 3 | SER A 101TYR A 126PRO A 107 | None | 0.65A | 4lbgB-5hvmA:3.6 | 4lbgB-5hvmA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hvo | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) (Aspergillusfumigatus) |
PF00982(Glyco_transf_20) | 3 | SER A 100TYR A 125PRO A 106 | None | 0.72A | 4lbgB-5hvoA:4.8 | 4lbgB-5hvoA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hxa | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) (Paraburkholderiaxenovorans) |
PF00982(Glyco_transf_20) | 3 | SER A 89TYR A 114PRO A 95 | None | 0.74A | 4lbgB-5hxaA:4.8 | 4lbgB-5hxaA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i85 | SPHINGOMYELINPHOSPHODIESTERASE (Homo sapiens) |
PF00149(Metallophos) | 3 | SER A 199TYR A 372PRO A 269 | NoneNAG A 711 (-4.6A)None | 0.95A | 4lbgB-5i85A:2.4 | 4lbgB-5i85A:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbk | BETA-GLUCOSIDASE (Trichodermaharzianum) |
PF00232(Glyco_hydro_1) | 3 | SER A 451TYR A 393PRO A 448 | None | 0.90A | 4lbgB-5jbkA:3.4 | 4lbgB-5jbkA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jij | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE (Mycolicibacteriumthermoresistibile) |
PF00982(Glyco_transf_20) | 3 | SER A 94TYR A 119PRO A 100 | None | 0.69A | 4lbgB-5jijA:4.5 | 4lbgB-5jijA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxm | PRIB (Streptomycessp. RM-5-8) |
PF11991(Trp_DMAT) | 3 | SER A 96TYR A 380PRO A 105 | NoneTRS A 501 ( 4.5A)None | 0.89A | 4lbgB-5jxmA:undetectable | 4lbgB-5jxmA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k9t | PROTEIN TRANSLOCASESUBUNIT SECA (Escherichiacoli) |
PF01043(SecA_PP_bind)PF07517(SecA_DEAD) | 3 | SER A 232TYR A 236PRO A 228 | None | 0.82A | 4lbgB-5k9tA:undetectable | 4lbgB-5k9tA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l7v | GLYCOSIDE HYDROLASE (Bacteroidesvulgatus) |
PF13320(DUF4091) | 3 | SER A 497TYR A 491PRO A 443 | None | 0.80A | 4lbgB-5l7vA:undetectable | 4lbgB-5l7vA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5loi | RAD26 (Thermothelomycesthermophila) |
PF12331(DUF3636) | 3 | SER A 531TYR A 527PRO A 535 | None | 0.94A | 4lbgB-5loiA:undetectable | 4lbgB-5loiA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m76 | LIGHT CHAIN DIMER (Homo sapiens) |
no annotation | 3 | SER A 178TYR A 180PRO A 167 | None | 0.95A | 4lbgB-5m76A:undetectable | 4lbgB-5m76A:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n7q | PUTATIVE CATHEPSIN D (Ixodes ricinus) |
no annotation | 3 | SER A 39TYR A 79PRO A 139 | None | 0.79A | 4lbgB-5n7qA:undetectable | 4lbgB-5n7qA:13.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5thm | ESTERASE-6 (Drosophilamelanogaster) |
PF00135(COesterase) | 3 | SER A 26TYR A 24PRO A 62 | NoneNoneMLY A 60 ( 4.3A) | 0.82A | 4lbgB-5thmA:undetectable | 4lbgB-5thmA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tvg | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) (Burkholderiavietnamiensis) |
PF00982(Glyco_transf_20) | 3 | SER A 82TYR A 107PRO A 88 | None | 0.71A | 4lbgB-5tvgA:3.7 | 4lbgB-5tvgA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ue0 | CT622 PROTEIN (Chlamydiatrachomatis) |
no annotation | 3 | SER A 471TYR A 478PRO A 383 | None | 0.90A | 4lbgB-5ue0A:undetectable | 4lbgB-5ue0A:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v0t | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) (Paraburkholderiaxenovorans) |
PF00982(Glyco_transf_20) | 3 | SER A 90TYR A 115PRO A 96 | None | 0.73A | 4lbgB-5v0tA:4.3 | 4lbgB-5v0tA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v0t | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) (Paraburkholderiaxenovorans) |
PF00982(Glyco_transf_20) | 3 | SER A 281TYR A 280PRO A 166 | None | 0.93A | 4lbgB-5v0tA:4.3 | 4lbgB-5v0tA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wwo | ESSENTIAL NUCLEARPROTEIN 1 (Saccharomycescerevisiae) |
PF05291(Bystin) | 3 | SER A 352TYR A 380PRO A 314 | None | 0.94A | 4lbgB-5wwoA:undetectable | 4lbgB-5wwoA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xeb | ENVELOPEGLYCOPROTEIN (Dhorithogotovirus) |
PF03273(Baculo_gp64) | 3 | SER A 160TYR A 146PRO A 115 | None | 0.96A | 4lbgB-5xebA:undetectable | 4lbgB-5xebA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3r | DNA-DEPENDENTPROTEIN KINASECATALYTIC SUBUNIT (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF02259(FAT)PF02260(FATC)PF08163(NUC194) | 3 | SER C2051TYR C2004PRO C2061 | None | 0.71A | 4lbgB-5y3rC:undetectable | 4lbgB-5y3rC:6.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yhp | COLD ACTIVE PROLINEIMINOPEPTIDASE (Glaciozymaantarctica) |
no annotation | 3 | SER A 233TYR A 181PRO A 44 | None | 0.92A | 4lbgB-5yhpA:undetectable | 4lbgB-5yhpA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yow | GLYCOPROTEINPOLYPROTEIN (Heartland virus) |
no annotation | 3 | SER A 317TYR A 315PRO A 37 | None | 0.93A | 4lbgB-5yowA:undetectable | 4lbgB-5yowA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ze8 | CYTOCHROME C552 (Thermochromatiumtepidum) |
no annotation | 3 | SER A 42TYR A 53PRO A 119 | HEM A 503 ( 4.7A)NoneNone | 0.87A | 4lbgB-5ze8A:undetectable | 4lbgB-5ze8A:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c4r | STAPHYLOPINEDEHYDROGENASE (Staphylococcusaureus) |
no annotation | 3 | SER A 123TYR A 96PRO A 202 | None | 0.61A | 4lbgB-6c4rA:undetectable | 4lbgB-6c4rA:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cbp | DH270.6 SINGLE CHAINVARIABLE FRAGMENT (Homo sapiens) |
no annotation | 3 | SER A 108TYR A 106PRO A 112 | NoneNAG A 302 ( 4.9A)None | 0.92A | 4lbgB-6cbpA:undetectable | 4lbgB-6cbpA:9.83 |