SIMILAR PATTERNS OF AMINO ACIDS FOR 4LBG_A_ADNA402_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 13pk | 3-PHOSPHOGLYCERATEKINASE (Trypanosomabrucei) |
PF00162(PGK) | 5 | GLU A 387ILE A 356VAL A 326ALA A 335ILE A 329 | None | 0.99A | 4lbgA-13pkA:3.1 | 4lbgA-13pkA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cp2 | NITROGENASE IRONPROTEIN (Clostridiumpasteurianum) |
PF00142(Fer4_NifH) | 5 | ALA A 133ILE A 165ALA A 5ALA A 141ILE A 144 | None | 1.04A | 4lbgA-1cp2A:undetectable | 4lbgA-1cp2A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dbi | AK.1 SERINE PROTEASE (Bacillus sp.Ak1) |
PF00082(Peptidase_S8) | 5 | SER A 229ALA A 205ILE A 210ALA A 80ILE A 79 | None | 0.98A | 4lbgA-1dbiA:4.4 | 4lbgA-1dbiA:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gq7 | PROCLAVAMINATEAMIDINO HYDROLASE (Streptomycesclavuligerus) |
PF00491(Arginase) | 5 | SER A 291ILE A 297VAL A 277ALA A 244ILE A 236 | None | 1.08A | 4lbgA-1gq7A:2.8 | 4lbgA-1gq7A:25.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gqo | DEHYDROQUINASE (Bacillussubtilis) |
PF01220(DHquinase_II) | 5 | GLU A 97ALA A 119ILE A 70ALA A 87ILE A 60 | None | 0.95A | 4lbgA-1gqoA:3.8 | 4lbgA-1gqoA:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iwp | GLYCEROL DEHYDRATASEALPHA SUBUNIT (Klebsiellapneumoniae) |
PF02286(Dehydratase_LU) | 5 | GLU A 436ALA A 440ALA A 186ALA A 156ILE A 420 | None | 1.05A | 4lbgA-1iwpA:undetectable | 4lbgA-1iwpA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jvb | NAD(H)-DEPENDENTALCOHOLDEHYDROGENASE (Sulfolobussolfataricus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 91ILE A 30VAL A 130ALA A 35ALA A 34 | None | 1.03A | 4lbgA-1jvbA:3.7 | 4lbgA-1jvbA:24.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1krq | FERRITIN (Campylobacterjejuni) |
PF00210(Ferritin) | 5 | ALA A 39ILE A 137VAL A 138ALA A 154ILE A 141 | None | 1.06A | 4lbgA-1krqA:undetectable | 4lbgA-1krqA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oi1 | SCML2 PROTEIN (Homo sapiens) |
PF02820(MBT) | 6 | ALA A 47ILE A 194VAL A 202ALA A 180ALA A 192ILE A 204 | None | 1.44A | 4lbgA-1oi1A:undetectable | 4lbgA-1oi1A:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p9s | REPLICASEPOLYPROTEIN 1AB (Humancoronavirus229E) |
PF05409(Peptidase_C30) | 5 | SER A 138ILE A 135VAL A 127ALA A 115ILE A 113 | None | 1.03A | 4lbgA-1p9sA:undetectable | 4lbgA-1p9sA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t1e | KUMAMOLISIN (Bacillus sp.MN-32) |
PF00082(Peptidase_S8)PF09286(Pro-kuma_activ) | 6 | THR A 346SER A 312ALA A 218ILE A 284ALA A 478ALA A 474 | None | 1.47A | 4lbgA-1t1eA:4.6 | 4lbgA-1t1eA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uls | PUTATIVE3-OXOACYL-ACYLCARRIER PROTEINREDUCTASE (Thermusthermophilus) |
PF13561(adh_short_C2) | 6 | GLU A 165ILE A 171VAL A 173ALA A 116ALA A 119ILE A 131 | None | 1.39A | 4lbgA-1ulsA:6.7 | 4lbgA-1ulsA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vbg | PYRUVATE,ORTHOPHOSPHATE DIKINASE (Zea mays) |
PF00391(PEP-utilizers)PF01326(PPDK_N)PF02896(PEP-utilizers_C) | 5 | THR A 551VAL A 618ALA A 543ALA A 541ILE A 560 | None | 1.03A | 4lbgA-1vbgA:2.2 | 4lbgA-1vbgA:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wnb | PUTATIVE BETAINEALDEHYDEDEHYDROGENASE (Escherichiacoli) |
PF00171(Aldedh) | 5 | SER A 37VAL A 12ALA A 43ALA A 44ILE A 7 | None | 1.07A | 4lbgA-1wnbA:3.3 | 4lbgA-1wnbA:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zq1 | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT E (Pyrococcusabyssi) |
PF02637(GatB_Yqey)PF02934(GatB_N)PF02938(GAD) | 6 | THR C 192ILE C 254VAL C 245ALA C 206ALA C 202ILE C 251 | None | 1.43A | 4lbgA-1zq1C:undetectable | 4lbgA-1zq1C:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2an2 | P332G A333S DOUBLEMUTANT OF NITRICOXIDE SYNTHASE FROMBACILLUS SUBTILIS (Bacillussubtilis) |
PF02898(NO_synthase) | 5 | ALA A 283ILE A 198VAL A 260ALA A 276ILE A 261 | None | 1.07A | 4lbgA-2an2A:undetectable | 4lbgA-2an2A:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bgk | RHIZOMESECOISOLARICIRESINOLDEHYDROGENASE (Podophyllumpeltatum) |
PF13561(adh_short_C2) | 6 | GLU A 184ILE A 190VAL A 192ALA A 133ALA A 136ILE A 148 | None | 1.41A | 4lbgA-2bgkA:6.9 | 4lbgA-2bgkA:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cxh | PROBABLE BRIX-DOMAINRIBOSOMAL BIOGENESISPROTEIN (Aeropyrumpernix) |
no annotation | 5 | ALA A 137VAL A 167ALA A 157ALA A 123ILE A 159 | None | 1.00A | 4lbgA-2cxhA:undetectable | 4lbgA-2cxhA:24.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2db3 | ATP-DEPENDENT RNAHELICASE VASA (Drosophilamelanogaster) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | SER A 550ILE A 558VAL A 561ALA A 545ILE A 493 | None | 0.97A | 4lbgA-2db3A:2.2 | 4lbgA-2db3A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eer | NAD-DEPENDENTALCOHOLDEHYDROGENASE (Sulfurisphaeratokodaii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | ALA A 91ILE A 30VAL A 130ALA A 35ALA A 34ILE A 32 | None | 1.13A | 4lbgA-2eerA:3.8 | 4lbgA-2eerA:25.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fyw | CONSERVEDHYPOTHETICAL PROTEIN (Streptococcuspneumoniae) |
PF01784(NIF3) | 5 | THR A 259ILE A 93VAL A 95ALA A 42ILE A 61 | None | 0.98A | 4lbgA-2fywA:undetectable | 4lbgA-2fywA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g2o | MALONYL COA-ACYLCARRIER PROTEINTRANSACYLASE (Escherichiacoli) |
PF00698(Acyl_transf_1) | 6 | SER A 142ALA A 146ILE A 169VAL A 167ALA A 188ILE A 135 | None | 1.24A | 4lbgA-2g2oA:undetectable | 4lbgA-2g2oA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gp6 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Mycobacteriumtuberculosis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 6 | ALA A 329ILE A 305VAL A 308ALA A 411ALA A 294ILE A 399 | None | 1.42A | 4lbgA-2gp6A:undetectable | 4lbgA-2gp6A:25.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kyr | FRUCTOSE-LIKEPHOSPHOTRANSFERASEENZYME IIB COMPONENT1 (Escherichiacoli) |
PF02302(PTS_IIB) | 5 | GLU A 100ALA A 28ILE A 95ALA A 7ILE A 62 | None | 1.06A | 4lbgA-2kyrA:4.7 | 4lbgA-2kyrA:16.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ozv | HYPOTHETICAL PROTEINATU0636 (Agrobacteriumfabrum) |
PF05175(MTS) | 5 | ALA A 84ILE A 100VAL A 71ALA A 58ALA A 57 | None | 1.05A | 4lbgA-2ozvA:5.1 | 4lbgA-2ozvA:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ph3 | 3-OXOACYL-[ACYLCARRIER PROTEIN]REDUCTASE (Thermusthermophilus) |
PF13561(adh_short_C2) | 5 | GLU A 41VAL A 56ALA A 9ALA A 18ILE A 30 | None | 1.07A | 4lbgA-2ph3A:7.1 | 4lbgA-2ph3A:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q01 | URONATE ISOMERASE (Caulobactervibrioides) |
PF02614(UxaC) | 5 | GLU A 170VAL A 191ALA A 48ALA A 181ILE A 182 | None | 1.03A | 4lbgA-2q01A:undetectable | 4lbgA-2q01A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r6r | CELL DIVISIONPROTEIN FTSZ (Aquifexaeolicus) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | ALA 1 110ILE 1 39ALA 1 77ALA 1 78ILE 1 57 | None | 1.01A | 4lbgA-2r6r1:7.9 | 4lbgA-2r6r1:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rml | COPPER-TRANSPORTINGP-TYPE ATPASE COPA (Bacillussubtilis) |
PF00403(HMA) | 5 | ILE A 8VAL A 48ALA A 59ALA A 58ILE A 60 | None | 1.03A | 4lbgA-2rmlA:undetectable | 4lbgA-2rmlA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xec | PUTATIVE MALEATEISOMERASE (Nocardiafarcinica) |
no annotation | 5 | ILE A 191VAL A 203ALA A 218CYH A 194ALA A 217 | NoneNoneNoneTRS A 300 (-3.1A)None | 1.07A | 4lbgA-2xecA:undetectable | 4lbgA-2xecA:26.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yrf | METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE (Bacillussubtilis) |
PF01008(IF-2B) | 5 | ALA A 263ILE A 266VAL A 235ALA A 223ALA A 224 | None | 0.95A | 4lbgA-2yrfA:3.2 | 4lbgA-2yrfA:24.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z0j | PUTATIVEUNCHARACTERIZEDPROTEIN TTHA1438 (Thermusthermophilus) |
PF04029(2-ph_phosp) | 5 | ALA A 159ILE A 138VAL A 22ALA A 121ALA A 125 | None | 1.07A | 4lbgA-2z0jA:undetectable | 4lbgA-2z0jA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b3l | KETOHEXOKINASE (Homo sapiens) |
PF00294(PfkB) | 6 | GLU A 227ALA A 244VAL A 250ALA A 256CYH A 282ALA A 285 | None | 0.72A | 4lbgA-3b3lA:27.9 | 4lbgA-3b3lA:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3brs | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Lachnoclostridiumphytofermentans) |
PF13407(Peripla_BP_4) | 5 | ALA A 73ILE A 11ALA A 82ALA A 83ILE A 58 | None | 1.03A | 4lbgA-3brsA:5.3 | 4lbgA-3brsA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3buu | UNCHARACTERIZED LOLASUPERFAMILY PROTEINNE2245 (Nitrosomonaseuropaea) |
PF17131(LolA_like) | 5 | THR A 171SER A 120VAL A 108ALA A 135ILE A 99 | None | 1.07A | 4lbgA-3buuA:undetectable | 4lbgA-3buuA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqn | GLUCAN1,3-BETA-GLUCOSIDASE (Phanerochaetechrysosporium) |
PF12708(Pectate_lyase_3) | 5 | THR A 408ILE A 440ALA A 402ALA A 413ILE A 414 | None | 1.07A | 4lbgA-3eqnA:undetectable | 4lbgA-3eqnA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fed | GLUTAMATECARBOXYPEPTIDASE III (Homo sapiens) |
PF02225(PA)PF04253(TFR_dimer)PF04389(Peptidase_M28) | 5 | THR A 468ALA A 572ILE A 388VAL A 384ALA A 525 | None | 0.96A | 4lbgA-3fedA:undetectable | 4lbgA-3fedA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fj4 | MUCONATECYCLOISOMERASE (Pseudomonasprotegens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLU A 48ALA A 113ILE A 11ALA A 86ILE A 8 | None | 1.04A | 4lbgA-3fj4A:2.7 | 4lbgA-3fj4A:24.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ALA A 98VAL A 94ALA A 58ALA A 85ILE A 89 | None | 1.07A | 4lbgA-3g1uA:4.8 | 4lbgA-3g1uA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ip1 | ALCOHOLDEHYDROGENASE,ZINC-CONTAINING (Thermotogamaritima) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 201ILE A 203ALA A 226ALA A 227ILE A 230 | None | 1.05A | 4lbgA-3ip1A:4.4 | 4lbgA-3ip1A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lhx | KETODEOXYGLUCONOKINASE (Shigellaflexneri) |
PF00294(PfkB) | 5 | ALA A 321VAL A 329ALA A 335ALA A 364ILE A 368 | None | 0.48A | 4lbgA-3lhxA:30.5 | 4lbgA-3lhxA:24.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lsc | TRIAZINE HYDROLASE (Paenarthrobacteraurescens) |
PF01979(Amidohydro_1) | 5 | GLU A 312ILE A 318VAL A 320ALA A 275ILE A 293 | None | 1.01A | 4lbgA-3lscA:3.1 | 4lbgA-3lscA:25.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3otx | ADENOSINE KINASE,PUTATIVE (Trypanosomabrucei) |
PF00294(PfkB) | 5 | THR A 264VAL A 291ALA A 297ALA A 326ILE A 330 | AP5 A 346 (-3.6A)AP5 A 346 ( 4.9A)AP5 A 346 (-3.4A)AP5 A 346 (-3.0A)AP5 A 346 (-4.9A) | 0.44A | 4lbgA-3otxA:39.5 | 4lbgA-3otxA:25.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p9t | REPRESSOR (Stenotrophomonasmaltophilia) |
PF00440(TetR_N)PF08361(TetR_C_2) | 5 | ALA A 39ILE A 37ALA A 11ALA A 47ILE A 16 | None | 1.07A | 4lbgA-3p9tA:undetectable | 4lbgA-3p9tA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p9x | PHOSPHORIBOSYLGLYCINAMIDEFORMYLTRANSFERASE (Bacillushalodurans) |
PF00551(Formyl_trans_N) | 5 | GLU A 16VAL A 31ALA A 8ALA A 87ILE A 6 | None | 1.01A | 4lbgA-3p9xA:4.6 | 4lbgA-3p9xA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qdl | OXYGEN-INSENSITIVENADPH NITROREDUCTASE (Helicobacterpylori) |
PF00881(Nitroreductase) | 5 | ILE A 186ALA A 40CYH A 140ALA A 143ILE A 147 | None | 1.04A | 4lbgA-3qdlA:undetectable | 4lbgA-3qdlA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3quf | EXTRACELLULARSOLUTE-BINDINGPROTEIN, FAMILY 1 (Bifidobacteriumlongum) |
PF13416(SBP_bac_8) | 5 | SER A 319ALA A 315ALA A 325ALA A 326ILE A 41 | None | 1.04A | 4lbgA-3qufA:undetectable | 4lbgA-3qufA:26.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tfj | GCVT-LIKEAMINOMETHYLTRANSFERASE PROTEIN (CandidatusPelagibacterubique) |
PF01571(GCV_T)PF08669(GCV_T_C) | 5 | THR A 305SER A 303ALA A 324ILE A 297ILE A 354 | None | 1.05A | 4lbgA-3tfjA:undetectable | 4lbgA-3tfjA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u9i | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME,C-TERMINAL DOMAINPROTEIN (Roseiflexus sp.RS-1) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 190ILE A 166ALA A 152ALA A 153ILE A 141 | None | 0.98A | 4lbgA-3u9iA:undetectable | 4lbgA-3u9iA:27.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 8 | THR A 245SER A 247GLU A 248ALA A 264VAL A 270ALA A 276ALA A 305ILE A 309 | ADP A 354 (-3.3A)ADP A 354 (-2.3A)ADP A 354 (-4.9A)ADP A 354 ( 4.0A)NoneADP A 354 (-3.4A)ADP A 354 (-2.7A)None | 0.51A | 4lbgA-3uboA:56.8 | 4lbgA-3uboA:71.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 6 | THR A 245SER A 247GLU A 248VAL A 270ALA A 276ILE A 309 | ADP A 354 (-3.3A)ADP A 354 (-2.3A)ADP A 354 (-4.9A)NoneADP A 354 (-3.4A)None | 1.29A | 4lbgA-3uboA:56.8 | 4lbgA-3uboA:71.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrd | FLAVOCYTOCHROME CFLAVIN SUBUNIT (Thermochromatiumtepidum) |
PF07992(Pyr_redox_2)PF09242(FCSD-flav_bind) | 5 | ALA B 24ILE B 28VAL B 30ALA B 17ALA B 316 | None | 1.05A | 4lbgA-3vrdB:undetectable | 4lbgA-3vrdB:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrk | CARBONYL SULFIDEHYDROLASE (Thiobacillusthioparus) |
PF00484(Pro_CA) | 6 | ALA A 76ILE A 178VAL A 194ALA A 40CYH A 79ILE A 92 | None | 1.14A | 4lbgA-3vrkA:undetectable | 4lbgA-3vrkA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4av6 | K(+)-STIMULATEDPYROPHOSPHATE-ENERGIZED SODIUM PUMP (Thermotogamaritima) |
PF03030(H_PPase) | 5 | SER A 247ILE A 708CYH A 183ALA A 187ILE A 704 | None | 0.95A | 4lbgA-4av6A:undetectable | 4lbgA-4av6A:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3i | FATTY ACIDBETA-OXIDATIONCOMPLEX BETA-CHAINFADA (Mycobacteriumtuberculosis) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA C 284VAL C 267ALA C 103ALA C 5ILE C 269 | None | 0.93A | 4lbgA-4b3iC:undetectable | 4lbgA-4b3iC:24.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bmv | SHORT-CHAINDEHYDROGENASE (Sphingobiumyanoikuyae) |
PF00106(adh_short) | 5 | GLU A 170ILE A 176VAL A 178ALA A 120ILE A 135 | None | 0.98A | 4lbgA-4bmvA:6.0 | 4lbgA-4bmvA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bwg | SUBTILASE CYTOTOXIN,SUBUNIT B (Escherichiacoli) |
no annotation | 6 | THR B 93SER B 43GLU B 33ILE B 16VAL B 14ILE B 76 | None | 1.44A | 4lbgA-4bwgB:undetectable | 4lbgA-4bwgB:14.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cze | RODSHAPE-DETERMININGPROTEIN MREB (Caulobactervibrioides) |
PF06723(MreB_Mbl) | 5 | SER A 176ILE A 138VAL A 331ALA A 145ILE A 146 | None | 0.99A | 4lbgA-4czeA:undetectable | 4lbgA-4czeA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dgs | DEHYDROGENASE (Sinorhizobiummeliloti) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | SER A 165GLU A 168ILE A 151VAL A 153ALA A 108 | None | 1.07A | 4lbgA-4dgsA:4.1 | 4lbgA-4dgsA:29.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4e3a | SUGAR KINASE PROTEIN (Rhizobium etli) |
PF00294(PfkB) | 9 | THR A 243GLU A 246ALA A 262ILE A 265VAL A 268ALA A 274CYH A 300ALA A 303ILE A 307 | None | 0.29A | 4lbgA-4e3aA:62.4 | 4lbgA-4e3aA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4e3a | SUGAR KINASE PROTEIN (Rhizobium etli) |
PF00294(PfkB) | 6 | THR A 243GLU A 246ILE A 265VAL A 268ALA A 274ILE A 307 | None | 1.44A | 4lbgA-4e3aA:62.4 | 4lbgA-4e3aA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4e3a | SUGAR KINASE PROTEIN (Rhizobium etli) |
PF00294(PfkB) | 9 | THR A 243SER A 245GLU A 246ALA A 262VAL A 268ALA A 274CYH A 300ALA A 303ILE A 307 | None | 0.58A | 4lbgA-4e3aA:62.4 | 4lbgA-4e3aA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e84 | D-BETA-D-HEPTOSE7-PHOSPHATE KINASE (Burkholderiacenocepacia) |
PF00294(PfkB) | 6 | THR A 238SER A 240GLU A 241ALA A 257ALA A 268ALA A 297 | ANP A 501 (-3.8A)ANP A 501 (-3.3A)NoneANP A 501 ( 3.7A)ANP A 501 (-3.5A)ANP A 501 (-3.7A) | 0.54A | 4lbgA-4e84A:27.2 | 4lbgA-4e84A:28.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e84 | D-BETA-D-HEPTOSE7-PHOSPHATE KINASE (Burkholderiacenocepacia) |
PF00294(PfkB) | 6 | THR A 238SER A 240GLU A 241VAL A 262ALA A 268ALA A 297 | ANP A 501 (-3.8A)ANP A 501 (-3.3A)NoneANP A 501 (-4.4A)ANP A 501 (-3.5A)ANP A 501 (-3.7A) | 0.57A | 4lbgA-4e84A:27.2 | 4lbgA-4e84A:28.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eex | ALCOHOLDEHYDROGENASE 1 (Lactococcuslactis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 172ILE A 169VAL A 168ALA A 245ALA A 240 | None | 1.05A | 4lbgA-4eexA:4.1 | 4lbgA-4eexA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ej6 | PUTATIVEZINC-BINDINGDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | THR A 206ILE A 235VAL A 152ALA A 184ILE A 157 | None | 1.06A | 4lbgA-4ej6A:4.2 | 4lbgA-4ej6A:28.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g3m | RIBOFLAVINBIOSYNTHESIS PROTEINRIBD (Bacillussubtilis) |
PF00383(dCMP_cyt_deam_1)PF01872(RibD_C) | 5 | ILE A 92VAL A 95ALA A 28ALA A 54ILE A 67 | None | 1.04A | 4lbgA-4g3mA:undetectable | 4lbgA-4g3mA:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gic | HISTIDINOLDEHYDROGENASE (Methylococcuscapsulatus) |
PF00815(Histidinol_dh) | 5 | ALA A 273ILE A 6VAL A 4ALA A 258ILE A 290 | None | 1.06A | 4lbgA-4gicA:3.4 | 4lbgA-4gicA:24.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h14 | SPIKE GLYCOPROTEIN (Betacoronavirus1) |
PF16451(Spike_NTD) | 5 | THR A 230ALA A 105ILE A 125VAL A 140ALA A 221 | None | 1.01A | 4lbgA-4h14A:undetectable | 4lbgA-4h14A:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ijm | CIRCADIAN CLOCKPROTEIN KINASE KAIC (Synechococcuselongatus) |
PF06745(ATPase) | 5 | THR A 295SER A 299ALA A 376ALA A 316ILE A 346 | MG A 801 ( 2.6A)NoneNoneNoneNone | 0.93A | 4lbgA-4ijmA:3.1 | 4lbgA-4ijmA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4is2 | BILE ACID 3-ALPHAHYDROXYSTEROIDDEHYDROGENASE ([Clostridium]scindens) |
PF00106(adh_short) | 6 | GLU A 174ILE A 180VAL A 182ALA A 124ALA A 127ILE A 139 | None | 1.36A | 4lbgA-4is2A:6.7 | 4lbgA-4is2A:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4itu | SHORT-CHAINDEHYDROGENASE/REDUCTASE SDR (Xanthobacterautotrophicus) |
PF13561(adh_short_C2) | 5 | ALA A 32ILE A 231VAL A 230ALA A 24ILE A 23 | None | 1.05A | 4lbgA-4ituA:6.7 | 4lbgA-4ituA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhy | HYPOTHETICAL PROTEIN (Parabacteroidesdistasonis) |
PF14730(DUF4468) | 5 | THR A 47ILE A 82ALA A 178ALA A 55ILE A 56 | None | 1.02A | 4lbgA-4jhyA:undetectable | 4lbgA-4jhyA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jn6 | ACETALDEHYDEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF01118(Semialdhyde_dh)PF09290(AcetDehyd-dimer) | 5 | ALA B 119ILE B 292VAL B 288ALA B 95ILE B 96 | None | 1.08A | 4lbgA-4jn6B:5.9 | 4lbgA-4jn6B:21.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4jwv | SHORT CHAINENOYL-COA HYDRATASE (Novosphingobiumaromaticivorans) |
PF00378(ECH_1) | 5 | VAL A 176ALA A 99CYH A 115ALA A 116ILE A 119 | None | 0.96A | 4lbgA-4jwvA:undetectable | 4lbgA-4jwvA:30.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mks | ENOLASE 2 (Lactobacillusgasseri) |
PF00113(Enolase_C)PF03952(Enolase_N) | 6 | SER A 115ALA A 23ILE A 7VAL A 79ALA A 110ILE A 75 | None | 1.28A | 4lbgA-4mksA:2.3 | 4lbgA-4mksA:25.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nxy | ACYL-COA SYNTHETASE (Streptomyceslividans) |
PF00583(Acetyltransf_1) | 5 | ALA A 122VAL A 103ALA A 146ALA A 149ILE A 145 | None | 1.07A | 4lbgA-4nxyA:undetectable | 4lbgA-4nxyA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o0m | CIRCADIAN CLOCKPROTEIN KINASE KAIC (Thermosynechococcuselongatus) |
PF06745(ATPase) | 5 | THR A 295SER A 299ALA A 376ALA A 316ILE A 346 | MG A 801 ( 3.1A)NoneNoneNoneNone | 0.96A | 4lbgA-4o0mA:2.8 | 4lbgA-4o0mA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o3s | DNA POLYMERASE ETA (Homo sapiens) |
PF00817(IMS)PF11799(IMS_C) | 5 | ALA A 54ALA A 65CYH A 72ALA A 68ILE A 47 | None | 1.01A | 4lbgA-4o3sA:undetectable | 4lbgA-4o3sA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oo0 | MAF-LIKE PROTEINBCAL2394 (Burkholderiacenocepacia) |
PF02545(Maf) | 5 | ILE A 189VAL A 150ALA A 182ALA A 183ILE A 186 | None | 0.98A | 4lbgA-4oo0A:undetectable | 4lbgA-4oo0A:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pir | 5-HYDROXYTRYPTAMINERECEPTOR 3A (Mus musculus) |
PF02931(Neur_chan_LBD)PF02932(Neur_chan_memb) | 5 | SER A 155ILE A 41VAL A 39ALA A 208ILE A 165 | None | 1.06A | 4lbgA-4pirA:undetectable | 4lbgA-4pirA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qfb | CT263 (Chlamydiatrachomatis) |
no annotation | 5 | THR A 17ALA A 185ILE A 109ALA A 70ILE A 68 | None | 1.07A | 4lbgA-4qfbA:undetectable | 4lbgA-4qfbA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qr8 | XAA-PRO DIPEPTIDASE (Escherichiacoli) |
PF00557(Peptidase_M24) | 5 | THR A 205GLU A 250ALA A 173VAL A 345ALA A 247 | None | 1.07A | 4lbgA-4qr8A:undetectable | 4lbgA-4qr8A:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ry9 | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Verminephrobactereiseniae) |
PF13407(Peripla_BP_4) | 5 | ALA A 163ILE A 253ALA A 244ALA A 241ILE A 245 | None | 1.07A | 4lbgA-4ry9A:4.5 | 4lbgA-4ry9A:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v15 | D-THREONINE ALDOLASE (Achromobacterxylosoxidans) |
PF01168(Ala_racemase_N)PF14031(D-ser_dehydrat) | 5 | ALA A 137VAL A 123ALA A 116ALA A 143ILE A 145 | None | 1.03A | 4lbgA-4v15A:undetectable | 4lbgA-4v15A:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x0o | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 PROTEIN 2 (Vibrio cholerae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | SER A 53ALA A 140CYH A 14ALA A 162ILE A 138 | None | 0.98A | 4lbgA-4x0oA:undetectable | 4lbgA-4x0oA:24.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x8r | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Rhodobactersphaeroides) |
PF03480(DctP) | 5 | GLU A 207ILE A 203VAL A 194ALA A 222ILE A 198 | None | 1.07A | 4lbgA-4x8rA:undetectable | 4lbgA-4x8rA:26.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a3k | PUTATIVEPTERIDINE-DEPENDENTDIOXYGENASE (Streptomyceshygroscopicus) |
no annotation | 5 | ALA A 312ILE A 292VAL A 294ALA A 262ILE A 335 | None | 0.95A | 4lbgA-5a3kA:undetectable | 4lbgA-5a3kA:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp8 | ENT-COPALYLDIPHOSPHATE SYNTHASE (Streptomycesplatensis) |
PF00432(Prenyltrans)PF13243(SQHop_cyclase_C) | 5 | ALA A 417ILE A 385ALA A 316ALA A 363ILE A 360 | None | 1.00A | 4lbgA-5bp8A:undetectable | 4lbgA-5bp8A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dqp | EDTA MONOOXYGENASE (EDTA-degradingbacterium BNC1) |
PF00296(Bac_luciferase) | 5 | GLU A 246ALA A 250VAL A 263ALA A 223ILE A 230 | None | 0.91A | 4lbgA-5dqpA:undetectable | 4lbgA-5dqpA:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hyo | PEDV 3CLPRO (Porcineepidemicdiarrhea virus) |
PF05409(Peptidase_C30) | 5 | SER A 138ILE A 135VAL A 127ALA A 115ILE A 113 | None | 1.04A | 4lbgA-5hyoA:undetectable | 4lbgA-5hyoA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l16 | PUTATIVESELENOPHOSPHATESYNTHETASE (Leishmaniamajor) |
PF00586(AIRS)PF02769(AIRS_C) | 5 | ALA A 151ILE A 178ALA A 251ALA A 252ILE A 173 | None | 0.97A | 4lbgA-5l16A:undetectable | 4lbgA-5l16A:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l16 | PUTATIVESELENOPHOSPHATESYNTHETASE (Leishmaniamajor) |
PF00586(AIRS)PF02769(AIRS_C) | 5 | GLU A 180ILE A 178ALA A 251ALA A 252ILE A 173 | None | 1.07A | 4lbgA-5l16A:undetectable | 4lbgA-5l16A:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wi5 | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE 1 (Streptococcuspneumoniae) |
PF00275(EPSP_synthase) | 5 | ALA A 177ILE A 186ALA A 136ALA A 158ILE A 160 | None | 1.06A | 4lbgA-5wi5A:undetectable | 4lbgA-5wi5A:24.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xjy | ATP-BINDING CASSETTESUB-FAMILY A MEMBER1 (Homo sapiens) |
PF00005(ABC_tran)PF12698(ABC2_membrane_3) | 5 | GLU A 662ILE A 655ALA A 746ALA A 747ILE A 656 | None | 0.96A | 4lbgA-5xjyA:undetectable | 4lbgA-5xjyA:9.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ydp | TETR TRANSCRIPTIONALREGULATORY PROTEIN (Dietzia sp.DQ12-45-1b) |
PF00440(TetR_N) | 5 | ALA A 159ILE A 93ALA A 175ALA A 176ILE A 179 | None | 0.90A | 4lbgA-5ydpA:undetectable | 4lbgA-5ydpA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6byn | WD REPEAT-CONTAININGPROTEIN 5 (Homo sapiens) |
no annotation | 5 | SER W 96ALA W 94ILE W 144VAL W 158ILE W 113 | None | 1.06A | 4lbgA-6bynW:undetectable | 4lbgA-6bynW:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c43 | GAMMA-AMINOBUTYRALDEHYDE DEHYDROGENASE (Salmonellaenterica) |
no annotation | 5 | SER A 37VAL A 12ALA A 43ALA A 44ILE A 7 | None | 1.06A | 4lbgA-6c43A:3.1 | 4lbgA-6c43A:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d46 | BETA SLIDING CLAMP (Rickettsiatyphi) |
no annotation | 5 | SER A 141ILE A 146ALA A 169ALA A 170ILE A 158 | None | 1.02A | 4lbgA-6d46A:undetectable | 4lbgA-6d46A:16.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f0k | POLYSULPHIDEREDUCTASE NRFD (Rhodothermusmarinus) |
no annotation | 5 | ALA C 290ILE C 300ALA C 121ALA C 120ILE C 117 | None | 1.06A | 4lbgA-6f0kC:undetectable | 4lbgA-6f0kC:14.38 |