SIMILAR PATTERNS OF AMINO ACIDS FOR 4LBG_A_ADNA402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE


(Trypanosoma
brucei)
PF00162
(PGK)
5 GLU A 387
ILE A 356
VAL A 326
ALA A 335
ILE A 329
None
0.99A 4lbgA-13pkA:
3.1
4lbgA-13pkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp2 NITROGENASE IRON
PROTEIN


(Clostridium
pasteurianum)
PF00142
(Fer4_NifH)
5 ALA A 133
ILE A 165
ALA A   5
ALA A 141
ILE A 144
None
1.04A 4lbgA-1cp2A:
undetectable
4lbgA-1cp2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1)
PF00082
(Peptidase_S8)
5 SER A 229
ALA A 205
ILE A 210
ALA A  80
ILE A  79
None
0.98A 4lbgA-1dbiA:
4.4
4lbgA-1dbiA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE


(Streptomyces
clavuligerus)
PF00491
(Arginase)
5 SER A 291
ILE A 297
VAL A 277
ALA A 244
ILE A 236
None
1.08A 4lbgA-1gq7A:
2.8
4lbgA-1gq7A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqo DEHYDROQUINASE

(Bacillus
subtilis)
PF01220
(DHquinase_II)
5 GLU A  97
ALA A 119
ILE A  70
ALA A  87
ILE A  60
None
0.95A 4lbgA-1gqoA:
3.8
4lbgA-1gqoA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT


(Klebsiella
pneumoniae)
PF02286
(Dehydratase_LU)
5 GLU A 436
ALA A 440
ALA A 186
ALA A 156
ILE A 420
None
1.05A 4lbgA-1iwpA:
undetectable
4lbgA-1iwpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Sulfolobus
solfataricus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A  91
ILE A  30
VAL A 130
ALA A  35
ALA A  34
None
1.03A 4lbgA-1jvbA:
3.7
4lbgA-1jvbA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krq FERRITIN

(Campylobacter
jejuni)
PF00210
(Ferritin)
5 ALA A  39
ILE A 137
VAL A 138
ALA A 154
ILE A 141
None
1.06A 4lbgA-1krqA:
undetectable
4lbgA-1krqA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi1 SCML2 PROTEIN

(Homo sapiens)
PF02820
(MBT)
6 ALA A  47
ILE A 194
VAL A 202
ALA A 180
ALA A 192
ILE A 204
None
1.44A 4lbgA-1oi1A:
undetectable
4lbgA-1oi1A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9s REPLICASE
POLYPROTEIN 1AB


(Human
coronavirus
229E)
PF05409
(Peptidase_C30)
5 SER A 138
ILE A 135
VAL A 127
ALA A 115
ILE A 113
None
1.03A 4lbgA-1p9sA:
undetectable
4lbgA-1p9sA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32)
PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ)
6 THR A 346
SER A 312
ALA A 218
ILE A 284
ALA A 478
ALA A 474
None
1.47A 4lbgA-1t1eA:
4.6
4lbgA-1t1eA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE


(Thermus
thermophilus)
PF13561
(adh_short_C2)
6 GLU A 165
ILE A 171
VAL A 173
ALA A 116
ALA A 119
ILE A 131
None
1.39A 4lbgA-1ulsA:
6.7
4lbgA-1ulsA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE


(Zea mays)
PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C)
5 THR A 551
VAL A 618
ALA A 543
ALA A 541
ILE A 560
None
1.03A 4lbgA-1vbgA:
2.2
4lbgA-1vbgA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE


(Escherichia
coli)
PF00171
(Aldedh)
5 SER A  37
VAL A  12
ALA A  43
ALA A  44
ILE A   7
None
1.07A 4lbgA-1wnbA:
3.3
4lbgA-1wnbA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E


(Pyrococcus
abyssi)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD)
6 THR C 192
ILE C 254
VAL C 245
ALA C 206
ALA C 202
ILE C 251
None
1.43A 4lbgA-1zq1C:
undetectable
4lbgA-1zq1C:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS


(Bacillus
subtilis)
PF02898
(NO_synthase)
5 ALA A 283
ILE A 198
VAL A 260
ALA A 276
ILE A 261
None
1.07A 4lbgA-2an2A:
undetectable
4lbgA-2an2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE


(Podophyllum
peltatum)
PF13561
(adh_short_C2)
6 GLU A 184
ILE A 190
VAL A 192
ALA A 133
ALA A 136
ILE A 148
None
1.41A 4lbgA-2bgkA:
6.9
4lbgA-2bgkA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN


(Aeropyrum
pernix)
no annotation 5 ALA A 137
VAL A 167
ALA A 157
ALA A 123
ILE A 159
None
1.00A 4lbgA-2cxhA:
undetectable
4lbgA-2cxhA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA


(Drosophila
melanogaster)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 SER A 550
ILE A 558
VAL A 561
ALA A 545
ILE A 493
None
0.97A 4lbgA-2db3A:
2.2
4lbgA-2db3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Sulfurisphaera
tokodaii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
6 ALA A  91
ILE A  30
VAL A 130
ALA A  35
ALA A  34
ILE A  32
None
1.13A 4lbgA-2eerA:
3.8
4lbgA-2eerA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyw CONSERVED
HYPOTHETICAL PROTEIN


(Streptococcus
pneumoniae)
PF01784
(NIF3)
5 THR A 259
ILE A  93
VAL A  95
ALA A  42
ILE A  61
None
0.98A 4lbgA-2fywA:
undetectable
4lbgA-2fywA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE


(Escherichia
coli)
PF00698
(Acyl_transf_1)
6 SER A 142
ALA A 146
ILE A 169
VAL A 167
ALA A 188
ILE A 135
None
1.24A 4lbgA-2g2oA:
undetectable
4lbgA-2g2oA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Mycobacterium
tuberculosis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
6 ALA A 329
ILE A 305
VAL A 308
ALA A 411
ALA A 294
ILE A 399
None
1.42A 4lbgA-2gp6A:
undetectable
4lbgA-2gp6A:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyr FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
1


(Escherichia
coli)
PF02302
(PTS_IIB)
5 GLU A 100
ALA A  28
ILE A  95
ALA A   7
ILE A  62
None
1.06A 4lbgA-2kyrA:
4.7
4lbgA-2kyrA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozv HYPOTHETICAL PROTEIN
ATU0636


(Agrobacterium
fabrum)
PF05175
(MTS)
5 ALA A  84
ILE A 100
VAL A  71
ALA A  58
ALA A  57
None
1.05A 4lbgA-2ozvA:
5.1
4lbgA-2ozvA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE


(Thermus
thermophilus)
PF13561
(adh_short_C2)
5 GLU A  41
VAL A  56
ALA A   9
ALA A  18
ILE A  30
None
1.07A 4lbgA-2ph3A:
7.1
4lbgA-2ph3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides)
PF02614
(UxaC)
5 GLU A 170
VAL A 191
ALA A  48
ALA A 181
ILE A 182
None
1.03A 4lbgA-2q01A:
undetectable
4lbgA-2q01A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ


(Aquifex
aeolicus)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
5 ALA 1 110
ILE 1  39
ALA 1  77
ALA 1  78
ILE 1  57
None
1.01A 4lbgA-2r6r1:
7.9
4lbgA-2r6r1:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rml COPPER-TRANSPORTING
P-TYPE ATPASE COPA


(Bacillus
subtilis)
PF00403
(HMA)
5 ILE A   8
VAL A  48
ALA A  59
ALA A  58
ILE A  60
None
1.03A 4lbgA-2rmlA:
undetectable
4lbgA-2rmlA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE


(Nocardia
farcinica)
no annotation 5 ILE A 191
VAL A 203
ALA A 218
CYH A 194
ALA A 217
None
None
None
TRS  A 300 (-3.1A)
None
1.07A 4lbgA-2xecA:
undetectable
4lbgA-2xecA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE


(Bacillus
subtilis)
PF01008
(IF-2B)
5 ALA A 263
ILE A 266
VAL A 235
ALA A 223
ALA A 224
None
0.95A 4lbgA-2yrfA:
3.2
4lbgA-2yrfA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0j PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1438


(Thermus
thermophilus)
PF04029
(2-ph_phosp)
5 ALA A 159
ILE A 138
VAL A  22
ALA A 121
ALA A 125
None
1.07A 4lbgA-2z0jA:
undetectable
4lbgA-2z0jA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3l KETOHEXOKINASE

(Homo sapiens)
PF00294
(PfkB)
6 GLU A 227
ALA A 244
VAL A 250
ALA A 256
CYH A 282
ALA A 285
None
0.72A 4lbgA-3b3lA:
27.9
4lbgA-3b3lA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR


(Lachnoclostridium
phytofermentans)
PF13407
(Peripla_BP_4)
5 ALA A  73
ILE A  11
ALA A  82
ALA A  83
ILE A  58
None
1.03A 4lbgA-3brsA:
5.3
4lbgA-3brsA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buu UNCHARACTERIZED LOLA
SUPERFAMILY PROTEIN
NE2245


(Nitrosomonas
europaea)
PF17131
(LolA_like)
5 THR A 171
SER A 120
VAL A 108
ALA A 135
ILE A  99
None
1.07A 4lbgA-3buuA:
undetectable
4lbgA-3buuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE


(Phanerochaete
chrysosporium)
PF12708
(Pectate_lyase_3)
5 THR A 408
ILE A 440
ALA A 402
ALA A 413
ILE A 414
None
1.07A 4lbgA-3eqnA:
undetectable
4lbgA-3eqnA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III


(Homo sapiens)
PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28)
5 THR A 468
ALA A 572
ILE A 388
VAL A 384
ALA A 525
None
0.96A 4lbgA-3fedA:
undetectable
4lbgA-3fedA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE


(Pseudomonas
protegens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLU A  48
ALA A 113
ILE A  11
ALA A  86
ILE A   8
None
1.04A 4lbgA-3fj4A:
2.7
4lbgA-3fj4A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE


(Leishmania
major)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 ALA A  98
VAL A  94
ALA A  58
ALA A  85
ILE A  89
None
1.07A 4lbgA-3g1uA:
4.8
4lbgA-3g1uA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING


(Thermotoga
maritima)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 201
ILE A 203
ALA A 226
ALA A 227
ILE A 230
None
1.05A 4lbgA-3ip1A:
4.4
4lbgA-3ip1A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhx KETODEOXYGLUCONOKINA
SE


(Shigella
flexneri)
PF00294
(PfkB)
5 ALA A 321
VAL A 329
ALA A 335
ALA A 364
ILE A 368
None
0.48A 4lbgA-3lhxA:
30.5
4lbgA-3lhxA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens)
PF01979
(Amidohydro_1)
5 GLU A 312
ILE A 318
VAL A 320
ALA A 275
ILE A 293
None
1.01A 4lbgA-3lscA:
3.1
4lbgA-3lscA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otx ADENOSINE KINASE,
PUTATIVE


(Trypanosoma
brucei)
PF00294
(PfkB)
5 THR A 264
VAL A 291
ALA A 297
ALA A 326
ILE A 330
AP5  A 346 (-3.6A)
AP5  A 346 ( 4.9A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.0A)
AP5  A 346 (-4.9A)
0.44A 4lbgA-3otxA:
39.5
4lbgA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9t REPRESSOR

(Stenotrophomonas
maltophilia)
PF00440
(TetR_N)
PF08361
(TetR_C_2)
5 ALA A  39
ILE A  37
ALA A  11
ALA A  47
ILE A  16
None
1.07A 4lbgA-3p9tA:
undetectable
4lbgA-3p9tA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9x PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE


(Bacillus
halodurans)
PF00551
(Formyl_trans_N)
5 GLU A  16
VAL A  31
ALA A   8
ALA A  87
ILE A   6
None
1.01A 4lbgA-3p9xA:
4.6
4lbgA-3p9xA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdl OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE


(Helicobacter
pylori)
PF00881
(Nitroreductase)
5 ILE A 186
ALA A  40
CYH A 140
ALA A 143
ILE A 147
None
1.04A 4lbgA-3qdlA:
undetectable
4lbgA-3qdlA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quf EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1


(Bifidobacterium
longum)
PF13416
(SBP_bac_8)
5 SER A 319
ALA A 315
ALA A 325
ALA A 326
ILE A  41
None
1.04A 4lbgA-3qufA:
undetectable
4lbgA-3qufA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfj GCVT-LIKE
AMINOMETHYLTRANSFERA
SE PROTEIN


(Candidatus
Pelagibacter
ubique)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
5 THR A 305
SER A 303
ALA A 324
ILE A 297
ILE A 354
None
1.05A 4lbgA-3tfjA:
undetectable
4lbgA-3tfjA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9i MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN


(Roseiflexus sp.
RS-1)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A 190
ILE A 166
ALA A 152
ALA A 153
ILE A 141
None
0.98A 4lbgA-3u9iA:
undetectable
4lbgA-3u9iA:
27.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti)
PF00294
(PfkB)
8 THR A 245
SER A 247
GLU A 248
ALA A 264
VAL A 270
ALA A 276
ALA A 305
ILE A 309
ADP  A 354 (-3.3A)
ADP  A 354 (-2.3A)
ADP  A 354 (-4.9A)
ADP  A 354 ( 4.0A)
None
ADP  A 354 (-3.4A)
ADP  A 354 (-2.7A)
None
0.51A 4lbgA-3uboA:
56.8
4lbgA-3uboA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti)
PF00294
(PfkB)
6 THR A 245
SER A 247
GLU A 248
VAL A 270
ALA A 276
ILE A 309
ADP  A 354 (-3.3A)
ADP  A 354 (-2.3A)
ADP  A 354 (-4.9A)
None
ADP  A 354 (-3.4A)
None
1.29A 4lbgA-3uboA:
56.8
4lbgA-3uboA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT


(Thermochromatium
tepidum)
PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind)
5 ALA B  24
ILE B  28
VAL B  30
ALA B  17
ALA B 316
None
1.05A 4lbgA-3vrdB:
undetectable
4lbgA-3vrdB:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrk CARBONYL SULFIDE
HYDROLASE


(Thiobacillus
thioparus)
PF00484
(Pro_CA)
6 ALA A  76
ILE A 178
VAL A 194
ALA A  40
CYH A  79
ILE A  92
None
1.14A 4lbgA-3vrkA:
undetectable
4lbgA-3vrkA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP


(Thermotoga
maritima)
PF03030
(H_PPase)
5 SER A 247
ILE A 708
CYH A 183
ALA A 187
ILE A 704
None
0.95A 4lbgA-4av6A:
undetectable
4lbgA-4av6A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA


(Mycobacterium
tuberculosis)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ALA C 284
VAL C 267
ALA C 103
ALA C   5
ILE C 269
None
0.93A 4lbgA-4b3iC:
undetectable
4lbgA-4b3iC:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmv SHORT-CHAIN
DEHYDROGENASE


(Sphingobium
yanoikuyae)
PF00106
(adh_short)
5 GLU A 170
ILE A 176
VAL A 178
ALA A 120
ILE A 135
None
0.98A 4lbgA-4bmvA:
6.0
4lbgA-4bmvA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwg SUBTILASE CYTOTOXIN,
SUBUNIT B


(Escherichia
coli)
no annotation 6 THR B  93
SER B  43
GLU B  33
ILE B  16
VAL B  14
ILE B  76
None
1.44A 4lbgA-4bwgB:
undetectable
4lbgA-4bwgB:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cze ROD
SHAPE-DETERMINING
PROTEIN MREB


(Caulobacter
vibrioides)
PF06723
(MreB_Mbl)
5 SER A 176
ILE A 138
VAL A 331
ALA A 145
ILE A 146
None
0.99A 4lbgA-4czeA:
undetectable
4lbgA-4czeA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgs DEHYDROGENASE

(Sinorhizobium
meliloti)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 SER A 165
GLU A 168
ILE A 151
VAL A 153
ALA A 108
None
1.07A 4lbgA-4dgsA:
4.1
4lbgA-4dgsA:
29.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli)
PF00294
(PfkB)
9 THR A 243
GLU A 246
ALA A 262
ILE A 265
VAL A 268
ALA A 274
CYH A 300
ALA A 303
ILE A 307
None
0.29A 4lbgA-4e3aA:
62.4
4lbgA-4e3aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli)
PF00294
(PfkB)
6 THR A 243
GLU A 246
ILE A 265
VAL A 268
ALA A 274
ILE A 307
None
1.44A 4lbgA-4e3aA:
62.4
4lbgA-4e3aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli)
PF00294
(PfkB)
9 THR A 243
SER A 245
GLU A 246
ALA A 262
VAL A 268
ALA A 274
CYH A 300
ALA A 303
ILE A 307
None
0.58A 4lbgA-4e3aA:
62.4
4lbgA-4e3aA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e84 D-BETA-D-HEPTOSE
7-PHOSPHATE KINASE


(Burkholderia
cenocepacia)
PF00294
(PfkB)
6 THR A 238
SER A 240
GLU A 241
ALA A 257
ALA A 268
ALA A 297
ANP  A 501 (-3.8A)
ANP  A 501 (-3.3A)
None
ANP  A 501 ( 3.7A)
ANP  A 501 (-3.5A)
ANP  A 501 (-3.7A)
0.54A 4lbgA-4e84A:
27.2
4lbgA-4e84A:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e84 D-BETA-D-HEPTOSE
7-PHOSPHATE KINASE


(Burkholderia
cenocepacia)
PF00294
(PfkB)
6 THR A 238
SER A 240
GLU A 241
VAL A 262
ALA A 268
ALA A 297
ANP  A 501 (-3.8A)
ANP  A 501 (-3.3A)
None
ANP  A 501 (-4.4A)
ANP  A 501 (-3.5A)
ANP  A 501 (-3.7A)
0.57A 4lbgA-4e84A:
27.2
4lbgA-4e84A:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eex ALCOHOL
DEHYDROGENASE 1


(Lactococcus
lactis)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 172
ILE A 169
VAL A 168
ALA A 245
ALA A 240
None
1.05A 4lbgA-4eexA:
4.1
4lbgA-4eexA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 THR A 206
ILE A 235
VAL A 152
ALA A 184
ILE A 157
None
1.06A 4lbgA-4ej6A:
4.2
4lbgA-4ej6A:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD


(Bacillus
subtilis)
PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C)
5 ILE A  92
VAL A  95
ALA A  28
ALA A  54
ILE A  67
None
1.04A 4lbgA-4g3mA:
undetectable
4lbgA-4g3mA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gic HISTIDINOL
DEHYDROGENASE


(Methylococcus
capsulatus)
PF00815
(Histidinol_dh)
5 ALA A 273
ILE A   6
VAL A   4
ALA A 258
ILE A 290
None
1.06A 4lbgA-4gicA:
3.4
4lbgA-4gicA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h14 SPIKE GLYCOPROTEIN

(Betacoronavirus
1)
PF16451
(Spike_NTD)
5 THR A 230
ALA A 105
ILE A 125
VAL A 140
ALA A 221
None
1.01A 4lbgA-4h14A:
undetectable
4lbgA-4h14A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC


(Synechococcus
elongatus)
PF06745
(ATPase)
5 THR A 295
SER A 299
ALA A 376
ALA A 316
ILE A 346
MG  A 801 ( 2.6A)
None
None
None
None
0.93A 4lbgA-4ijmA:
3.1
4lbgA-4ijmA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE


([Clostridium]
scindens)
PF00106
(adh_short)
6 GLU A 174
ILE A 180
VAL A 182
ALA A 124
ALA A 127
ILE A 139
None
1.36A 4lbgA-4is2A:
6.7
4lbgA-4is2A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Xanthobacter
autotrophicus)
PF13561
(adh_short_C2)
5 ALA A  32
ILE A 231
VAL A 230
ALA A  24
ILE A  23
None
1.05A 4lbgA-4ituA:
6.7
4lbgA-4ituA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhy HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis)
PF14730
(DUF4468)
5 THR A  47
ILE A  82
ALA A 178
ALA A  55
ILE A  56
None
1.02A 4lbgA-4jhyA:
undetectable
4lbgA-4jhyA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 ACETALDEHYDE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer)
5 ALA B 119
ILE B 292
VAL B 288
ALA B  95
ILE B  96
None
1.08A 4lbgA-4jn6B:
5.9
4lbgA-4jn6B:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jwv SHORT CHAIN
ENOYL-COA HYDRATASE


(Novosphingobium
aromaticivorans)
PF00378
(ECH_1)
5 VAL A 176
ALA A  99
CYH A 115
ALA A 116
ILE A 119
None
0.96A 4lbgA-4jwvA:
undetectable
4lbgA-4jwvA:
30.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mks ENOLASE 2

(Lactobacillus
gasseri)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
6 SER A 115
ALA A  23
ILE A   7
VAL A  79
ALA A 110
ILE A  75
None
1.28A 4lbgA-4mksA:
2.3
4lbgA-4mksA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxy ACYL-COA SYNTHETASE

(Streptomyces
lividans)
PF00583
(Acetyltransf_1)
5 ALA A 122
VAL A 103
ALA A 146
ALA A 149
ILE A 145
None
1.07A 4lbgA-4nxyA:
undetectable
4lbgA-4nxyA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC


(Thermosynechococcus
elongatus)
PF06745
(ATPase)
5 THR A 295
SER A 299
ALA A 376
ALA A 316
ILE A 346
MG  A 801 ( 3.1A)
None
None
None
None
0.96A 4lbgA-4o0mA:
2.8
4lbgA-4o0mA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3s DNA POLYMERASE ETA

(Homo sapiens)
PF00817
(IMS)
PF11799
(IMS_C)
5 ALA A  54
ALA A  65
CYH A  72
ALA A  68
ILE A  47
None
1.01A 4lbgA-4o3sA:
undetectable
4lbgA-4o3sA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo0 MAF-LIKE PROTEIN
BCAL2394


(Burkholderia
cenocepacia)
PF02545
(Maf)
5 ILE A 189
VAL A 150
ALA A 182
ALA A 183
ILE A 186
None
0.98A 4lbgA-4oo0A:
undetectable
4lbgA-4oo0A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A


(Mus musculus)
PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb)
5 SER A 155
ILE A  41
VAL A  39
ALA A 208
ILE A 165
None
1.06A 4lbgA-4pirA:
undetectable
4lbgA-4pirA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfb CT263

(Chlamydia
trachomatis)
no annotation 5 THR A  17
ALA A 185
ILE A 109
ALA A  70
ILE A  68
None
1.07A 4lbgA-4qfbA:
undetectable
4lbgA-4qfbA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qr8 XAA-PRO DIPEPTIDASE

(Escherichia
coli)
PF00557
(Peptidase_M24)
5 THR A 205
GLU A 250
ALA A 173
VAL A 345
ALA A 247
None
1.07A 4lbgA-4qr8A:
undetectable
4lbgA-4qr8A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR


(Verminephrobacter
eiseniae)
PF13407
(Peripla_BP_4)
5 ALA A 163
ILE A 253
ALA A 244
ALA A 241
ILE A 245
None
1.07A 4lbgA-4ry9A:
4.5
4lbgA-4ry9A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v15 D-THREONINE ALDOLASE

(Achromobacter
xylosoxidans)
PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat)
5 ALA A 137
VAL A 123
ALA A 116
ALA A 143
ILE A 145
None
1.03A 4lbgA-4v15A:
undetectable
4lbgA-4v15A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2


(Vibrio cholerae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 SER A  53
ALA A 140
CYH A  14
ALA A 162
ILE A 138
None
0.98A 4lbgA-4x0oA:
undetectable
4lbgA-4x0oA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Rhodobacter
sphaeroides)
PF03480
(DctP)
5 GLU A 207
ILE A 203
VAL A 194
ALA A 222
ILE A 198
None
1.07A 4lbgA-4x8rA:
undetectable
4lbgA-4x8rA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE


(Streptomyces
hygroscopicus)
no annotation 5 ALA A 312
ILE A 292
VAL A 294
ALA A 262
ILE A 335
None
0.95A 4lbgA-5a3kA:
undetectable
4lbgA-5a3kA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE


(Streptomyces
platensis)
PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C)
5 ALA A 417
ILE A 385
ALA A 316
ALA A 363
ILE A 360
None
1.00A 4lbgA-5bp8A:
undetectable
4lbgA-5bp8A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1)
PF00296
(Bac_luciferase)
5 GLU A 246
ALA A 250
VAL A 263
ALA A 223
ILE A 230
None
0.91A 4lbgA-5dqpA:
undetectable
4lbgA-5dqpA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyo PEDV 3CLPRO

(Porcine
epidemic
diarrhea virus)
PF05409
(Peptidase_C30)
5 SER A 138
ILE A 135
VAL A 127
ALA A 115
ILE A 113
None
1.04A 4lbgA-5hyoA:
undetectable
4lbgA-5hyoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE


(Leishmania
major)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 ALA A 151
ILE A 178
ALA A 251
ALA A 252
ILE A 173
None
0.97A 4lbgA-5l16A:
undetectable
4lbgA-5l16A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE


(Leishmania
major)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 GLU A 180
ILE A 178
ALA A 251
ALA A 252
ILE A 173
None
1.07A 4lbgA-5l16A:
undetectable
4lbgA-5l16A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1


(Streptococcus
pneumoniae)
PF00275
(EPSP_synthase)
5 ALA A 177
ILE A 186
ALA A 136
ALA A 158
ILE A 160
None
1.06A 4lbgA-5wi5A:
undetectable
4lbgA-5wi5A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1


(Homo sapiens)
PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3)
5 GLU A 662
ILE A 655
ALA A 746
ALA A 747
ILE A 656
None
0.96A 4lbgA-5xjyA:
undetectable
4lbgA-5xjyA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydp TETR TRANSCRIPTIONAL
REGULATORY PROTEIN


(Dietzia sp.
DQ12-45-1b)
PF00440
(TetR_N)
5 ALA A 159
ILE A  93
ALA A 175
ALA A 176
ILE A 179
None
0.90A 4lbgA-5ydpA:
undetectable
4lbgA-5ydpA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byn WD REPEAT-CONTAINING
PROTEIN 5


(Homo sapiens)
no annotation 5 SER W  96
ALA W  94
ILE W 144
VAL W 158
ILE W 113
None
1.06A 4lbgA-6bynW:
undetectable
4lbgA-6bynW:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE


(Salmonella
enterica)
no annotation 5 SER A  37
VAL A  12
ALA A  43
ALA A  44
ILE A   7
None
1.06A 4lbgA-6c43A:
3.1
4lbgA-6c43A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi)
no annotation 5 SER A 141
ILE A 146
ALA A 169
ALA A 170
ILE A 158
None
1.02A 4lbgA-6d46A:
undetectable
4lbgA-6d46A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k POLYSULPHIDE
REDUCTASE NRFD


(Rhodothermus
marinus)
no annotation 5 ALA C 290
ILE C 300
ALA C 121
ALA C 120
ILE C 117
None
1.06A 4lbgA-6f0kC:
undetectable
4lbgA-6f0kC:
14.38