SIMILAR PATTERNS OF AMINO ACIDS FOR 4LB9_A_EVPA605_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vx4 CELLVIBRIO JAPONICUS
MANNANASE CJMAN26C

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		5 ASP A 266
ARG A 267
ALA A 315
GLN A 312
GLY A 340
 None
 1.29A 4lb9A-2vx4A:
0.2		 4lb9A-2vx4A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbj PUTATIVE
THIOESTERASE II

(Thermobifida
fusca) 		PF13622
(4HBT_3) 		5 ASP A  26
TYR A  39
ARG A 149
ALA A 148
GLY A  38
 None
 1.45A 4lb9A-3bbjA:
0.0		 4lb9A-3bbjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fys PROTEIN DEGV

(Bacillus
subtilis) 		PF02645
(DegV) 		5 TYR A 260
CYH A 120
ALA A 122
GLN A 123
GLY A 262
 None
PLM  A 501 ( 3.9A)
None
None
None
 1.43A 4lb9A-3fysA:
0.0		 4lb9A-3fysA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvm OLEI00960

(Oleispira
antarctica) 		PF00561
(Abhydrolase_1) 		5 ASP A  86
TYR A  61
SER A  67
HIS A 104
GLY A  35
 None
 1.38A 4lb9A-3qvmA:
0.8		 4lb9A-3qvmA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia) 		PF00933
(Glyco_hydro_3) 		5 TYR A 108
ARG A 115
ALA A 314
HIS A 158
GLY A 159
 None
 1.21A 4lb9A-4g6cA:
0.2		 4lb9A-4g6cA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 ASP A 329
HIS A 232
TYR A 292
ALA A 287
GLY A 294
 None
 1.33A 4lb9A-4uplA:
0.1		 4lb9A-4uplA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B

(Roseobacter
denitrificans) 		PF00115
(COX1) 		5 HIS A 396
TYR A 324
ARG A 399
HIS A 319
GLY A 320
 None
 1.34A 4lb9A-4xydA:
1.2		 4lb9A-4xydA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbt ACETOACETATE
DECARBOXYLASE

(Streptomyces
bingchenggensis) 		PF06314
(ADC) 		5 TYR A   4
SER A  69
ARG A 114
ALA A 110
GLY A   3
 None
None
PYR  A 301 (-3.7A)
None
None
 1.40A 4lb9A-4zbtA:
undetectable		 4lb9A-4zbtA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 5 HIS A 463
SER A 120
GLN A 570
HIS A 485
GLY A 453
 None
 1.49A 4lb9A-5ohsA:
1.6		 4lb9A-5ohsA:
undetectable