SIMILAR PATTERNS OF AMINO ACIDS FOR 4LB2_B_DM5B602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bun BETA2-BUNGAROTOXIN

(Bungarus
multicinctus) 		PF00068
(Phospholip_A2_1) 		5 VAL A  47
ALA A  97
PHE A 101
TYR A 106
TYR A  25
 None
 1.46A 4lb2B-1bunA:
2.1		 4lb2B-1bunA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmz PHOSPHOLIPASE A2

(Bothrops
pirajai) 		PF00068
(Phospholip_A2_1) 		5 VAL A  46
ALA A  92
PHE A  96
TYR A 103
TYR A  24
 None
 1.39A 4lb2B-1gmzA:
2.1		 4lb2B-1gmzA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ijl PHOSPHOLIPASE A2

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		5 VAL A  46
ALA A  92
PHE A  96
TYR A 103
TYR A  24
 None
 1.42A 4lb2B-1ijlA:
1.1		 4lb2B-1ijlA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jia PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		5 VAL A  47
ALA A 102
PHE A 106
TYR A 113
TYR A  25
 None
 1.42A 4lb2B-1jiaA:
2.0		 4lb2B-1jiaA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m8r PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		5 VAL A  47
ALA A 102
PHE A 106
TYR A 113
TYR A  25
 None
 1.48A 4lb2B-1m8rA:
2.0		 4lb2B-1m8rA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2

(Crotalus atrox) 		no annotation 5 VAL R  47
ALA R 102
PHE R 106
TYR R 113
TYR R  25
 None
 1.48A 4lb2B-1pp2R:
1.9		 4lb2B-1pp2R:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6v PHOSPHOLIPASE A2
VRV-PL-VIIIA

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		5 VAL A  47
ALA A 102
PHE A 106
TYR A 113
TYR A  25
 None
 1.47A 4lb2B-1q6vA:
2.1		 4lb2B-1q6vA:
11.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 PRO A 118
VAL A 122
ALA A 126
PHE A 134
TYR A 138
 None
 1.04A 4lb2B-1tf0A:
48.5		 4lb2B-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 PRO A 118
VAL A 122
MET A 123
ALA A 126
PHE A 134
TYR A 138
PHE A 165
 None
 0.53A 4lb2B-1tf0A:
48.5		 4lb2B-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 VAL A 122
ALA A 126
PHE A 134
LYS A 137
PHE A 165
 None
 1.23A 4lb2B-1tf0A:
48.5		 4lb2B-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vap PHOSPHOLIPASE A2

(Agkistrodon
piscivorus) 		PF00068
(Phospholip_A2_1) 		5 VAL A  46
ALA A  92
PHE A  96
TYR A 103
TYR A  24
 None
 1.47A 4lb2B-1vapA:
1.4		 4lb2B-1vapA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vip PHOSPHOLIPASE A2

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		5 VAL A  47
ALA A 102
PHE A 106
TYR A 113
TYR A  25
 None
 1.44A 4lb2B-1vipA:
2.0		 4lb2B-1vipA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl7 HYPOTENSIVE
PHOSPHOLIPASE A2

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		5 VAL A  46
ALA A  92
PHE A  96
TYR A 103
TYR A  24
 None
 1.49A 4lb2B-1zl7A:
undetectable		 4lb2B-1zl7A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4c PHOSPHOLIPASE A2-II

(Daboia
siamensis) 		PF00068
(Phospholip_A2_1) 		5 VAL B  47
ALA B 102
PHE B 106
TYR B 113
TYR B  25
 None
 1.41A 4lb2B-2h4cB:
undetectable		 4lb2B-2h4cB:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		5 VAL A 401
MET A 400
ALA A 399
PHE A 347
TYR A 298
 None
None
None
None
TRS  A 500 (-4.1A)
 1.39A 4lb2B-3ahyA:
undetectable		 4lb2B-3ahyA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dih PHOSPHOLIPASE A2
HOMOLOG, AMMODYTIN L

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		5 VAL A  46
ALA A  92
PHE A  96
TYR A 103
TYR A  24
 None
 1.46A 4lb2B-3dihA:
undetectable		 4lb2B-3dihA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8g PHOSPHOLIPASE A2,
AMMODYTOXIN A

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		5 VAL A  46
ALA A  92
PHE A  96
TYR A 103
TYR A  24
 None
 1.45A 4lb2B-3g8gA:
1.9		 4lb2B-3g8gA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		5 PRO A 185
VAL A 290
ALA A 279
PHE A 188
PHE A 299
 None
 1.35A 4lb2B-4f3eA:
2.0		 4lb2B-4f3eA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 PRO M 158
VAL N 366
ALA N 364
PHE N 349
TYR N 346
 None
 1.50A 4lb2B-4heaM:
2.2		 4lb2B-4heaM:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		5 PRO A 176
VAL A 209
ALA A 153
PHE A 154
PHE A 150
 None
 1.12A 4lb2B-4lz6A:
0.5		 4lb2B-4lz6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN

(Salmonella
enterica) 		PF13343
(SBP_bac_6) 		5 PRO A 157
VAL A 166
MET A 167
PHE A 181
PHE A 171
 None
 1.41A 4lb2B-4r6yA:
undetectable		 4lb2B-4r6yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfp ACIDIC PHOSPHOLIPASE
A2 5

(Trimeresurus
stejnegeri) 		PF00068
(Phospholip_A2_1) 		5 VAL A  46
ALA A  92
PHE A  96
TYR A 103
TYR A  24
 None
None
None
PEG  A 201 ( 4.1A)
None
 1.47A 4lb2B-4rfpA:
undetectable		 4lb2B-4rfpA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 VAL A 359
MET A 360
ALA A 363
PHE A 364
PHE A 388
 None
 1.49A 4lb2B-4z3yA:
undetectable		 4lb2B-4z3yA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfv BASIC PHOSPHOLIPASE
A2 MYOTOXIN III

(Bothrops asper) 		PF00068
(Phospholip_A2_1) 		5 VAL A  47
ALA A 102
PHE A 106
TYR A 113
TYR A  25
 None
 1.38A 4lb2B-5tfvA:
undetectable		 4lb2B-5tfvA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 VAL A 291
MET A 292
ALA A 295
PHE A 296
TYR A  71
 None
 1.43A 4lb2B-5weoA:
2.4		 4lb2B-5weoA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 7 PRO A 118
MET A 123
ALA A 126
PHE A 134
LYS A 137
TYR A 138
PHE A 165
 None
 0.60A 4lb2B-5yxeA:
46.6		 4lb2B-5yxeA:
11.11