SIMILAR PATTERNS OF AMINO ACIDS FOR 4LB2_B_DM5B601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LEU A 639
PRO A 190
TYR A 686
GLU A 689
ILE A 690
 None
 1.24A 4lb2B-1pd1A:
0.9		 4lb2B-1pd1A:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LEU A 115
VAL A 116
TYR A 138
GLU A 141
ILE A 142
 None
 0.68A 4lb2B-1tf0A:
48.5		 4lb2B-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 VAL A 116
PRO A 118
TYR A 138
ILE A 142
TYR A 161
 None
 1.07A 4lb2B-1tf0A:
48.5		 4lb2B-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsb RAS
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00017
(SH2) 		5 LEU A  42
VAL A  43
PRO A  45
TYR A  29
ILE A  63
 None
 1.22A 4lb2B-2gsbA:
undetectable		 4lb2B-2gsbA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 LEU A 151
VAL A 123
PRO A 149
LYS A 208
ILE A 185
 None
 1.28A 4lb2B-2o7qA:
0.0		 4lb2B-2o7qA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		5 LEU A 532
VAL A 528
TYR A 608
ILE A 291
TYR A 670
 None
 1.45A 4lb2B-3ayfA:
0.0		 4lb2B-3ayfA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		5 LEU A 532
VAL A 533
TYR A 608
ILE A 291
TYR A 670
 None
 1.11A 4lb2B-3ayfA:
0.0		 4lb2B-3ayfA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz2 UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09754
(PAC2) 		5 LEU A   9
VAL A  10
GLU A  97
ILE A  98
TYR A  23
 None
 1.22A 4lb2B-3wz2A:
0.0		 4lb2B-3wz2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk4 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP) 		5 LEU A 302
VAL A 326
PRO A 338
TYR A 274
ILE A 264
 None
 1.37A 4lb2B-4wk4A:
undetectable		 4lb2B-4wk4A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgm DIHYDROOROTASE

(Vibrio cholerae) 		PF01979
(Amidohydro_1) 		5 LEU A  74
VAL A  46
PRO A  45
GLU A  84
ILE A  85
 None
 1.48A 4lb2B-5vgmA:
0.3		 4lb2B-5vgmA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 LEU A 158
VAL A 157
PRO A 308
TYR A 142
ILE A 312
 None
 1.24A 4lb2B-5xdrA:
0.8		 4lb2B-5xdrA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 LEU A 115
PRO A 118
TYR A 138
GLU A 141
ILE A 142
 None
 0.93A 4lb2B-5yxeA:
46.6		 4lb2B-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 LEU A 115
VAL A 116
PRO A 118
TYR A 138
ILE A 142
 None
 1.43A 4lb2B-5yxeA:
46.6		 4lb2B-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 LEU A 115
VAL A 116
TYR A 138
ILE A 142
TYR A 161
 None
 1.47A 4lb2B-5yxeA:
46.6		 4lb2B-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 PRO A 118
LYS A 137
TYR A 138
GLU A 141
ILE A 142
 None
 0.77A 4lb2B-5yxeA:
46.6		 4lb2B-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4n PSEUDOPALINE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 324
VAL A 325
PRO A 327
TYR A 320
ILE A 251
 None
 1.27A 4lb2B-6c4nA:
1.0		 4lb2B-6c4nA:
9.25