SIMILAR PATTERNS OF AMINO ACIDS FOR 4LB2_A_DM5A602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		4 VAL A  85
MET A  86
ALA A  89
TYR A 129
 None
 1.10A 4lb2A-1a4sA:
0.0		 4lb2A-1a4sA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00266
(Aminotran_5) 		4 PRO A 163
VAL A 171
ALA A 173
PHE A 175
 None
 0.80A 4lb2A-1bjnA:
undetectable		 4lb2A-1bjnA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE

(Methanothermobacter
thermautotrophicus) 		PF00908
(dTDP_sugar_isom) 		4 VAL A  56
ALA A 124
PHE A 122
TYR A 133
 None
 0.87A 4lb2A-1epzA:
undetectable		 4lb2A-1epzA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 PRO A 406
ALA A 430
PHE A 364
TYR A 349
 None
 1.04A 4lb2A-1flgA:
undetectable		 4lb2A-1flgA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		4 PRO A 326
VAL A 376
ALA A 374
PHE A 365
 None
 1.12A 4lb2A-1gcyA:
undetectable		 4lb2A-1gcyA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm6 ANNEXIN 1

(Sus scrofa) 		PF00191
(Annexin) 		4 VAL A 301
MET A 300
LYS A 281
TYR A 315
 None
 1.17A 4lb2A-1hm6A:
2.0		 4lb2A-1hm6A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		4 PRO A 267
VAL A 271
MET A 272
ALA A 275
 None
 0.41A 4lb2A-1m1cA:
0.0		 4lb2A-1m1cA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6b PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01467
(CTP_transf_like) 		4 PRO A  13
VAL A 132
ALA A 136
PHE A 158
 None
 0.59A 4lb2A-1o6bA:
undetectable		 4lb2A-1o6bA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 PRO A 302
VAL A 306
MET A 305
PHE A 274
 None
 1.04A 4lb2A-1przA:
undetectable		 4lb2A-1przA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 PRO A  52
VAL A  55
MET A  56
ALA A  59
 None
 1.15A 4lb2A-1rx0A:
0.2		 4lb2A-1rx0A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s6d ALBUMIN 8

(Helianthus
annuus) 		PF00234
(Tryp_alpha_amyl) 		4 VAL A  83
MET A  84
ALA A  87
TYR A   2
 None
 0.96A 4lb2A-1s6dA:
undetectable		 4lb2A-1s6dA:
10.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 PRO A 118
VAL A 122
ALA A 126
PHE A 134
TYR A 138
 None
 1.05A 4lb2A-1tf0A:
48.6		 4lb2A-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 PRO A 118
VAL A 122
MET A 123
ALA A 126
PHE A 134
 None
 0.38A 4lb2A-1tf0A:
48.6		 4lb2A-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		4 PRO A 252
VAL A 434
MET A 435
ALA A 438
 None
 0.63A 4lb2A-1thgA:
1.9		 4lb2A-1thgA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 PRO A 202
VAL A 285
MET A 284
TYR A 127
 None
 1.10A 4lb2A-1u8vA:
undetectable		 4lb2A-1u8vA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 PRO A 183
VAL A 319
MET A 318
ALA A 316
 None
 1.05A 4lb2A-1wu2A:
undetectable		 4lb2A-1wu2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		4 ALA A  84
PHE A  18
LYS A  22
TYR A  28
 SAH  A1001 ( 4.8A)
SAH  A1001 (-4.3A)
None
None
 0.94A 4lb2A-1wy7A:
undetectable		 4lb2A-1wy7A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PRO A 579
VAL A 602
ALA A 604
TYR A 380
 None
 1.01A 4lb2A-1xc6A:
undetectable		 4lb2A-1xc6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 PRO A  41
VAL A 460
ALA A 462
TYR A 428
 None
 1.15A 4lb2A-1xl8A:
undetectable		 4lb2A-1xl8A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01082
(Cu2_monooxygen)
PF03712
(Cu2_monoox_C) 		4 PRO A 151
VAL A 154
ALA A 202
TYR A 139
 None
 1.14A 4lb2A-1yjkA:
undetectable		 4lb2A-1yjkA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]

(Yellow fever
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 PRO A 348
VAL A 375
MET A 376
ALA A 378
 None
 0.90A 4lb2A-1yksA:
1.1		 4lb2A-1yksA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		4 PRO A 326
VAL A 376
ALA A 374
PHE A 365
 None
 1.14A 4lb2A-2amgA:
undetectable		 4lb2A-2amgA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Aquifex
aeolicus) 		PF00290
(Trp_syntA) 		4 VAL A 210
ALA A 228
PHE A 227
TYR A 191
 None
 1.10A 4lb2A-2ekcA:
undetectable		 4lb2A-2ekcA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785

(Thermus
thermophilus) 		PF01139
(RtcB) 		4 PRO A 354
ALA A 219
PHE A 223
TYR A 324
 None
 0.99A 4lb2A-2epgA:
undetectable		 4lb2A-2epgA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF00849
(PseudoU_synth_2)
PF01479
(S4) 		4 PRO A 302
VAL A 306
MET A 305
PHE A 274
 None
BCT  A 803 ( 4.1A)
None
None
 1.07A 4lb2A-2istA:
undetectable		 4lb2A-2istA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		4 PRO A 180
VAL A 214
ALA A 211
TYR A 144
 None
 1.03A 4lb2A-2jg5A:
undetectable		 4lb2A-2jg5A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mgy TRANSLOCATOR PROTEIN

(Mus musculus) 		PF03073
(TspO_MBR) 		4 VAL A  80
MET A  79
ALA A  78
PHE A  74
 None
 1.10A 4lb2A-2mgyA:
undetectable		 4lb2A-2mgyA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		4 MET A 157
ALA A 160
LYS A 436
TYR A 425
 None
 1.14A 4lb2A-2n0sA:
undetectable		 4lb2A-2n0sA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocz 3-DEHYDROQUINATE
DEHYDRATASE

(Streptococcus
pyogenes) 		PF01487
(DHquinase_I) 		4 VAL A 199
ALA A   5
LYS A  55
TYR A  92
 None
 1.07A 4lb2A-2oczA:
undetectable		 4lb2A-2oczA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5t PEZT

(Streptococcus
pneumoniae) 		PF06414
(Zeta_toxin) 		4 VAL B  98
MET B  97
ALA B  94
PHE B  93
 None
 1.17A 4lb2A-2p5tB:
undetectable		 4lb2A-2p5tB:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE

(Trypanosoma
cruzi) 		PF02685
(Glucokinase) 		4 VAL A  52
MET A  37
PHE A  26
TYR A 116
 None
 1.05A 4lb2A-2q2rA:
undetectable		 4lb2A-2q2rA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca) 		PF04672
(Methyltransf_19) 		4 PRO A 238
VAL A 241
ALA A 266
TYR A 190
 None
 0.89A 4lb2A-2qe6A:
undetectable		 4lb2A-2qe6A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0x POSSIBLE FLAVIN
REDUCTASE

(Histophilus
somni) 		PF01613
(Flavin_Reduct) 		4 VAL A  37
ALA A  34
PHE A  32
TYR A  58
 None
 1.06A 4lb2A-2r0xA:
undetectable		 4lb2A-2r0xA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9z GLUTATHIONE AMIDE
REDUCTASE

(Marichromatium
gracile) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A  52
MET A  53
ALA A  56
PHE A 188
 None
 0.86A 4lb2A-2r9zA:
undetectable		 4lb2A-2r9zA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 VAL A 739
MET A 740
ALA A 743
PHE A 752
 None
 0.92A 4lb2A-2vcaA:
undetectable		 4lb2A-2vcaA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9z G1/S-SPECIFIC
CYCLIN-D1

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		4 PRO A 157
VAL A 186
ALA A 190
TYR A  84
 None
 1.07A 4lb2A-2w9zA:
3.9		 4lb2A-2w9zA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtn EST1E

(Butyrivibrio
proteoclasticus) 		PF08386
(Abhydrolase_4)
PF12146
(Hydrolase_4) 		4 PRO A 127
VAL A 111
MET A 112
ALA A 115
 None
 0.82A 4lb2A-2wtnA:
undetectable		 4lb2A-2wtnA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE

(Bacillus
subtilis) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 PRO A 179
VAL A  38
ALA A  42
PHE A 186
 None
 1.03A 4lb2A-2x7jA:
undetectable		 4lb2A-2x7jA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 VAL A 214
ALA A 212
PHE A 240
TYR A 149
 None
 1.04A 4lb2A-2xsgA:
undetectable		 4lb2A-2xsgA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		4 VAL A 401
MET A 400
ALA A 399
PHE A 347
 None
 1.03A 4lb2A-3ahyA:
undetectable		 4lb2A-3ahyA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ax1 SERRATE RNA EFFECTOR
MOLECULE

(Arabidopsis
thaliana) 		PF04959
(ARS2)
PF12066
(DUF3546) 		4 VAL A 467
MET A 468
ALA A 470
TYR A 539
 None
 1.07A 4lb2A-3ax1A:
undetectable		 4lb2A-3ax1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1

(Mycobacterium
tuberculosis) 		PF00296
(Bac_luciferase) 		4 VAL A 181
ALA A 185
PHE A 192
TYR A 203
 F42  A 338 (-4.3A)
None
None
None
 0.92A 4lb2A-3b4yA:
1.2		 4lb2A-3b4yA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cng NUDIX HYDROLASE

(Nitrosomonas
europaea) 		PF00293
(NUDIX)
PF14803
(Nudix_N_2) 		4 PRO A  45
VAL A  94
ALA A  92
PHE A 124
 None
 1.02A 4lb2A-3cngA:
undetectable		 4lb2A-3cngA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8y SUSD/RAGB-ASSOCIATED
ESTERASE-LIKE
PROTEIN

(Bacteroides
vulgatus) 		PF12715
(Abhydrolase_7) 		4 VAL A  83
MET A  82
ALA A  81
PHE A 317
 None
None
EDO  A   6 ( 4.2A)
None
 1.08A 4lb2A-3g8yA:
undetectable		 4lb2A-3g8yA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 PRO A 359
VAL A 333
ALA A 327
TYR A 320
 None
 1.12A 4lb2A-3hhsA:
undetectable		 4lb2A-3hhsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		4 VAL A  31
ALA A  28
PHE A 430
TYR A 262
 None
 1.02A 4lb2A-3hidA:
2.2		 4lb2A-3hidA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 VAL A 432
ALA A 436
LYS A 491
TYR A 725
 None
 1.11A 4lb2A-3hmjA:
undetectable		 4lb2A-3hmjA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsy GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 VAL A 285
MET A 286
ALA A 289
PHE A 290
 None
 0.89A 4lb2A-3hsyA:
undetectable		 4lb2A-3hsyA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luy PROBABLE CHORISMATE
MUTASE

(Bifidobacterium
adolescentis) 		PF00800
(PDT) 		4 PRO A 104
VAL A  98
ALA A  96
PHE A 123
 None
 1.08A 4lb2A-3luyA:
undetectable		 4lb2A-3luyA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfi DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA49

(Saccharomyces
cerevisiae) 		PF06870
(RNA_pol_I_A49) 		4 VAL A 361
ALA A 395
LYS A 398
TYR A 202
 None
 1.13A 4lb2A-3nfiA:
undetectable		 4lb2A-3nfiA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbo PHOSPHOSERINE
AMINOTRANSFERASE

(Yersinia pestis) 		PF00266
(Aminotran_5) 		4 PRO A 163
VAL A 170
ALA A 172
PHE A 174
 None
 1.01A 4lb2A-3qboA:
undetectable		 4lb2A-3qboA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm2 PHOSPHOSERINE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		4 PRO A 163
VAL A 171
ALA A 173
PHE A 175
 None
 0.84A 4lb2A-3qm2A:
undetectable		 4lb2A-3qm2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3saj GLUTAMATE RECEPTOR 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 VAL A 281
MET A 282
ALA A 285
PHE A 286
 None
 0.91A 4lb2A-3sajA:
undetectable		 4lb2A-3sajA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Francisella
tularensis) 		PF01380
(SIS) 		4 PRO A 262
VAL A 447
MET A 448
ALA A 450
 None
 1.09A 4lb2A-3tbfA:
undetectable		 4lb2A-3tbfA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsn 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF04166
(PdxA) 		4 VAL A 120
ALA A 116
PHE A  35
TYR A  80
 None
 0.98A 4lb2A-3tsnA:
undetectable		 4lb2A-3tsnA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ub1 ORF13-LIKE PROTEIN

(Clostridium
perfringens) 		PF12642
(TpcC) 		4 PRO A 225
VAL A 209
ALA A 117
PHE A 121
 None
 1.16A 4lb2A-3ub1A:
undetectable		 4lb2A-3ub1A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		4 VAL A  40
ALA A  37
PHE A 446
TYR A 271
 None
 1.00A 4lb2A-3ue9A:
undetectable		 4lb2A-3ue9A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1j PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF01467
(CTP_transf_like) 		4 PRO A  12
VAL A 131
ALA A 135
PHE A 157
 None
 0.71A 4lb2A-3x1jA:
undetectable		 4lb2A-3x1jA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 VAL A 605
MET A 604
ALA A 601
TYR A 248
 None
 1.16A 4lb2A-4a01A:
undetectable		 4lb2A-4a01A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ann ESSB

(Staphylococcus
aureus) 		PF10140
(YukC) 		4 PRO A 142
VAL A 115
ALA A 131
PHE A  58
 None
 0.89A 4lb2A-4annA:
2.0		 4lb2A-4annA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxk ARYLSULFATASE

(Pseudomonas
aeruginosa) 		PF00884
(Sulfatase) 		4 PRO A 210
VAL A 287
MET A 286
ALA A 284
 None
 1.14A 4lb2A-4cxkA:
undetectable		 4lb2A-4cxkA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE

(Bacillus
anthracis) 		no annotation 4 PRO B 156
ALA B 162
PHE B 251
LYS B 244
 None
 1.01A 4lb2A-4fetB:
1.5		 4lb2A-4fetB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN

(Thermotoga
maritima;
Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		4 VAL A 403
MET A 402
ALA A 401
PHE A 351
 None
 0.97A 4lb2A-4gxpA:
undetectable		 4lb2A-4gxpA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iil MEMBRANE LIPOPROTEIN
TPN38(B)

(Treponema
pallidum) 		PF02608
(Bmp) 		4 PRO A 212
VAL A 221
ALA A 225
TYR A 240
 None
 1.09A 4lb2A-4iilA:
undetectable		 4lb2A-4iilA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbr GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF08718
(GLTP) 		4 PRO A 168
VAL A 172
ALA A 176
PHE A  42
 None
 0.69A 4lb2A-4kbrA:
undetectable		 4lb2A-4kbrA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		4 PRO A 176
VAL A 209
ALA A 153
PHE A 154
 None
 1.07A 4lb2A-4lz6A:
undetectable		 4lb2A-4lz6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1q L-LACTATE
DEHYDROGENASE

([Bacillus]
selenitireducens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 PRO A 123
VAL A 126
ALA A 130
PHE A 101
 None
 1.07A 4lb2A-4m1qA:
undetectable		 4lb2A-4m1qA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Staphylococcus
aureus) 		PF01467
(CTP_transf_like) 		4 PRO A  14
VAL A 133
ALA A 137
PHE A 159
 None
 0.77A 4lb2A-4natA:
undetectable		 4lb2A-4natA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN

(Cupriavidus
taiwanensis) 		PF13561
(adh_short_C2) 		4 VAL A   7
ALA A  30
PHE A  25
TYR A 222
 None
 1.16A 4lb2A-4nbvA:
undetectable		 4lb2A-4nbvA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4a LIPOPROTEIN,
PUTATIVE

(Bacillus
anthracis) 		no annotation 4 VAL A  52
ALA A  78
PHE A  72
TYR A  94
 None
 1.07A 4lb2A-4o4aA:
undetectable		 4lb2A-4o4aA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 VAL A4482
ALA A4480
PHE A4585
TYR A4524
 None
 1.05A 4lb2A-4opeA:
undetectable		 4lb2A-4opeA:
21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		4 PRO A 118
VAL A 122
ALA A 126
PHE A 134
 None
 0.43A 4lb2A-4po0A:
49.7		 4lb2A-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA

(Escherichia
coli;
Mus musculus) 		PF13416
(SBP_bac_8)
PF13621
(Cupin_8) 		4 PRO A -40
ALA A-203
LYS A-115
TYR A-216
 None
None
None
GLC  A 901 ( 3.8A)
 0.91A 4lb2A-4qszA:
undetectable		 4lb2A-4qszA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0c ABGT PUTATIVE
TRANSPORTER FAMILY

(Alcanivorax
borkumensis) 		PF03806
(ABG_transport) 		4 PRO A 405
VAL A 348
ALA A 344
PHE A  25
 None
 1.12A 4lb2A-4r0cA:
undetectable		 4lb2A-4r0cA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN

(Salmonella
enterica) 		PF13343
(SBP_bac_6) 		4 VAL A 166
MET A 167
ALA A 170
PHE A 171
 None
 1.16A 4lb2A-4r6yA:
undetectable		 4lb2A-4r6yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr3 ALANINE RACEMASE,
BIOSYNTHETIC

(Escherichia
coli) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 PRO A 210
VAL A  30
MET A  29
ALA A  52
 None
 1.11A 4lb2A-4wr3A:
undetectable		 4lb2A-4wr3A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzt CELLULOSE HYDROLASE

(Bacillus
licheniformis) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		4 VAL A 297
ALA A 291
PHE A 287
TYR A 222
 None
None
None
BGC  A 803 ( 4.9A)
 1.03A 4lb2A-4yztA:
undetectable		 4lb2A-4yztA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 VAL A 359
MET A 360
ALA A 363
PHE A 364
 None
 0.97A 4lb2A-4z3yA:
undetectable		 4lb2A-4z3yA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 PRO A 137
VAL A 169
MET A 168
ALA A 167
 None
 0.99A 4lb2A-4zo6A:
undetectable		 4lb2A-4zo6A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3m CEA1

(Komagataella
pastoris) 		PF10528
(GLEYA) 		4 PRO A 216
VAL A 124
ALA A 122
PHE A 120
 None
 1.05A 4lb2A-5a3mA:
undetectable		 4lb2A-5a3mA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19

(Escherichia
coli;
Tetrahymena
thermophila) 		PF13416
(SBP_bac_8) 		4 PRO A 331
ALA A 168
LYS A 256
TYR A 155
 None
None
None
MAL  A 601 (-4.0A)
 1.06A 4lb2A-5dfmA:
undetectable		 4lb2A-5dfmA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 PRO A1024
VAL A1105
ALA A1101
TYR A 949
 None
 0.99A 4lb2A-5ehkA:
undetectable		 4lb2A-5ehkA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Danio rerio;
Escherichia
coli) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 PRO A 332
ALA A 169
LYS A 257
TYR A 156
 None
None
None
MAL  A 501 (-4.2A)
 1.06A 4lb2A-5gppA:
undetectable		 4lb2A-5gppA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Dinoroseobacter
shibae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 PRO A 449
ALA A  21
PHE A  17
TYR A   7
 None
 1.05A 4lb2A-5gxdA:
undetectable		 4lb2A-5gxdA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3w FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN

(Streptococcus
suis) 		PF05670
(DUF814)
PF05833
(FbpA) 		4 PRO A 217
VAL A 221
ALA A 225
PHE A 199
 None
 0.72A 4lb2A-5h3wA:
undetectable		 4lb2A-5h3wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PRO A 870
ALA A 961
PHE A 891
TYR A 859
 None
 1.05A 4lb2A-5ihrA:
undetectable		 4lb2A-5ihrA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 VAL A 291
MET A 292
ALA A 295
PHE A 296
 None
 0.91A 4lb2A-5l1bA:
undetectable		 4lb2A-5l1bA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		4 PRO A1723
VAL A1747
ALA A1643
PHE A1641
 None
 1.11A 4lb2A-5lkiA:
undetectable		 4lb2A-5lkiA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nci LEUCINE HYDROXYLASE

(Streptomyces
muensis) 		PF05721
(PhyH) 		4 VAL A  30
MET A  31
ALA A  34
PHE A  68
 None
 1.03A 4lb2A-5nciA:
undetectable		 4lb2A-5nciA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7

(Homo sapiens) 		no annotation 4 PRO A 199
VAL A  25
ALA A  20
PHE A  16
 None
 1.08A 4lb2A-5nfnA:
undetectable		 4lb2A-5nfnA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		4 VAL A 505
ALA A 489
PHE A 487
TYR A 597
 None
 1.12A 4lb2A-5szsA:
undetectable		 4lb2A-5szsA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t12 PHOSPHOENOLPYRUVATE-
-PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF05524
(PEP-utilisers_N) 		4 VAL A 361
MET A 360
ALA A 363
TYR A 245
 None
 1.06A 4lb2A-5t12A:
undetectable		 4lb2A-5t12A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		4 VAL A 291
MET A 292
ALA A 295
PHE A 296
 None
 0.96A 4lb2A-5welA:
undetectable		 4lb2A-5welA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 VAL A 291
MET A 292
ALA A 295
PHE A 296
 None
 1.00A 4lb2A-5weoA:
undetectable		 4lb2A-5weoA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvs GDP/UDP-N,N'-DIACETY
LBACILLOSAMINE
2-EPIMERASE
(HYDROLYZING)

(Acinetobacter
baumannii) 		no annotation 4 PRO A 240
VAL A 250
ALA A 252
PHE A 224
 None
 1.04A 4lb2A-5xvsA:
undetectable		 4lb2A-5xvsA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 PRO A 118
MET A 123
ALA A 126
PHE A 134
LYS A 137
 None
 0.81A 4lb2A-5yxeA:
46.9		 4lb2A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 4 PRO A 147
VAL A 179
MET A 178
ALA A 177
 None
 0.85A 4lb2A-5z9sA:
undetectable		 4lb2A-5z9sA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 4 VAL A 179
MET A 178
ALA A 175
PHE A 164
 None
 1.15A 4lb2A-5z9sA:
undetectable		 4lb2A-5z9sA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 4 VAL A  31
ALA A  28
PHE A 430
TYR A 262
 None
 1.04A 4lb2A-6bs7A:
undetectable		 4lb2A-6bs7A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dku VP35

(Myotis
lucifugus) 		no annotation 4 PRO A 234
VAL A 190
MET A 189
ALA A 188
 None
 1.12A 4lb2A-6dkuA:
undetectable		 4lb2A-6dkuA:
undetectable