SIMILAR PATTERNS OF AMINO ACIDS FOR 4LB2_A_DM5A601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 197
VAL A 196
PRO A 372
LYS A 339
 None
 1.02A 4lb2A-1cg2A:
0.6		 4lb2A-1cg2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5f METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 345
VAL A 337
GLU A 343
TYR A 210
 None
SO4  A 407 (-4.1A)
None
None
 0.99A 4lb2A-1e5fA:
0.0		 4lb2A-1e5fA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A  94
VAL A  95
LYS A 187
GLU A 245
 None
 0.97A 4lb2A-1e5mA:
undetectable		 4lb2A-1e5mA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		4 LEU A 163
PRO A 154
LYS A 189
GLU A 190
 None
 1.05A 4lb2A-1o12A:
undetectable		 4lb2A-1o12A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 146
VAL A 145
PRO A 143
GLU A 416
 None
 1.10A 4lb2A-1p43A:
0.0		 4lb2A-1p43A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcj POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
americana) 		PF00161
(RIP) 		4 LEU A 168
VAL A 169
LYS A 133
GLU A 127
 None
 0.99A 4lb2A-1qcjA:
0.0		 4lb2A-1qcjA:
17.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 LEU A 115
VAL A 116
TYR A 138
GLU A 141
 None
 0.70A 4lb2A-1tf0A:
48.6		 4lb2A-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 VAL A 116
PRO A 118
TYR A 138
GLU A 141
 None
 0.78A 4lb2A-1tf0A:
48.6		 4lb2A-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfg POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol) 		4 LEU A 154
VAL A 151
PRO A 150
TYR A 215
 None
 1.07A 4lb2A-1vfgA:
0.4		 4lb2A-1vfgA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 LEU A 159
VAL A 158
PRO A 193
TYR A 237
 None
 0.77A 4lb2A-1xzwA:
undetectable		 4lb2A-1xzwA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN

(Pseudomonas
aeruginosa) 		PF04958
(AstA) 		4 LEU A  71
VAL A  15
PRO A  13
GLU A  64
 None
 0.96A 4lb2A-1yleA:
0.0		 4lb2A-1yleA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztc HYPOTHETICAL PROTEIN
TM0894

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		4 LEU A 195
VAL A 196
PRO A 198
TYR A 171
 None
 0.87A 4lb2A-1ztcA:
undetectable		 4lb2A-1ztcA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztc HYPOTHETICAL PROTEIN
TM0894

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		4 LEU A 195
VAL A 196
PRO A 198
TYR A 171
 None
 1.03A 4lb2A-1ztcA:
undetectable		 4lb2A-1ztcA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1

(Aquifex
aeolicus) 		PF00072
(Response_reg) 		4 LEU A   4
VAL A   5
LYS A  38
TYR A  37
 None
 0.93A 4lb2A-1zy2A:
undetectable		 4lb2A-1zy2A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9s TOPOISOMERASE I-LIKE
PROTEIN

(Leishmania
donovani) 		PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N) 		4 LEU A  55
VAL A 181
PRO A 183
GLU A 160
 None
 1.05A 4lb2A-2b9sA:
undetectable		 4lb2A-2b9sA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ek8 AMINOPEPTIDASE

(Aneurinibacillus
sp. AM-1) 		PF02225
(PA)
PF04389
(Peptidase_M28) 		4 LEU A 249
VAL A 245
LYS A  49
TYR A  53
 None
 0.95A 4lb2A-2ek8A:
undetectable		 4lb2A-2ek8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A 271
PRO A 122
GLU A 346
TYR A 349
 None
 1.05A 4lb2A-2ep5A:
0.3		 4lb2A-2ep5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erh COLICIN E7 IMMUNITY
PROTEIN

(Escherichia
coli) 		PF01320
(Colicin_Pyocin) 		4 LEU A  37
VAL A  36
GLU A  21
TYR A  10
 None
 1.12A 4lb2A-2erhA:
undetectable		 4lb2A-2erhA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gl5 PUTATIVE DEHYDRATASE
PROTEIN

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 128
VAL A 375
PRO A 377
GLU A 339
 None
 1.01A 4lb2A-2gl5A:
undetectable		 4lb2A-2gl5A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3f GLYCOLIPID
TRANSFER-LIKE
PROTEIN

(Galdieria
sulphuraria) 		PF08718
(GLTP) 		4 LEU A  98
VAL A  95
PRO A  89
GLU A 197
 None
 0.93A 4lb2A-2i3fA:
undetectable		 4lb2A-2i3fA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i54 PHOSPHOMANNOMUTASE

(Leishmania
mexicana) 		PF03332
(PMM) 		4 LEU A 105
PRO A 130
GLU A 159
TYR A 171
 None
 1.01A 4lb2A-2i54A:
undetectable		 4lb2A-2i54A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjx URIDYLATE KINASE

(Bacillus
anthracis) 		PF00696
(AA_kinase) 		4 LEU A   8
VAL A 146
PRO A 144
TYR A 113
 None
 1.01A 4lb2A-2jjxA:
undetectable		 4lb2A-2jjxA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfw FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD

(Escherichia
coli) 		PF00254
(FKBP_C) 		4 LEU A  22
VAL A  21
TYR A  13
GLU A  25
 None
 1.04A 4lb2A-2kfwA:
undetectable		 4lb2A-2kfwA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyz HYPOTHETICAL PROTEIN
GAMMAHV.M3

(Murid
gammaherpesvirus
4) 		PF09213
(M3) 		4 LEU A 281
PRO A 338
LYS A 267
TYR A 266
 None
 1.09A 4lb2A-2nyzA:
undetectable		 4lb2A-2nyzA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz2 ARGININOSUCCINATE
SYNTHASE

(Homo sapiens) 		PF00764
(Arginosuc_synth) 		4 VAL A 233
PRO A 232
TYR A 253
GLU A 249
 None
 1.05A 4lb2A-2nz2A:
undetectable		 4lb2A-2nz2A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE

(Phaseolus
vulgaris) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 LEU A 160
VAL A 159
PRO A 194
TYR A 238
 None
 0.79A 4lb2A-2qfrA:
undetectable		 4lb2A-2qfrA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		4 LEU A  61
VAL A  62
PRO A  64
GLU A  83
 None
 1.12A 4lb2A-2qioA:
undetectable		 4lb2A-2qioA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpt LIPOLYTIC ENZYME

(Ruminiclostridium
thermocellum) 		PF13472
(Lipase_GDSL_2) 		4 VAL A  41
PRO A  40
GLU A  47
TYR A 214
 None
 1.03A 4lb2A-2vptA:
undetectable		 4lb2A-2vptA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 LEU A  58
VAL A  59
PRO A  61
GLU A 371
 None
 1.03A 4lb2A-2vr2A:
undetectable		 4lb2A-2vr2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT BETA

(Rhodococcus
erythropolis) 		PF02211
(NHase_beta) 		4 LEU B  83
VAL B  80
TYR B  57
GLU B  54
 None
 0.82A 4lb2A-2zpbB:
undetectable		 4lb2A-2zpbB:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 VAL A 747
PRO A 651
TYR A 712
GLU A 735
 None
 1.02A 4lb2A-3ai7A:
undetectable		 4lb2A-3ai7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al9 PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 LEU A 159
VAL A 136
PRO A 151
TYR A 215
 None
 0.85A 4lb2A-3al9A:
0.4		 4lb2A-3al9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al9 PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 LEU A 159
VAL A 136
PRO A 151
TYR A 215
 None
 0.96A 4lb2A-3al9A:
0.4		 4lb2A-3al9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 LEU A 373
VAL A 372
PRO A 371
GLU A 568
 None
 1.07A 4lb2A-3bgaA:
undetectable		 4lb2A-3bgaA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Geobacter
sulfurreducens) 		PF00440
(TetR_N) 		4 LEU A  57
VAL A  56
TYR A 102
GLU A 105
 None
None
ACY  A 209 (-4.2A)
None
 0.97A 4lb2A-3dewA:
3.9		 4lb2A-3dewA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 LEU A 744
LYS A 751
GLU A 748
TYR A 664
 None
 1.00A 4lb2A-3ecqA:
undetectable		 4lb2A-3ecqA:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		4 LEU A 280
VAL A 281
PRO A 283
GLU A 217
 None
 0.86A 4lb2A-3f70A:
undetectable		 4lb2A-3f70A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9r PHOSPHOMANNOMUTASE

(Trypanosoma
brucei) 		PF03332
(PMM) 		4 LEU A 105
PRO A 130
GLU A 159
TYR A 171
 None
 1.03A 4lb2A-3f9rA:
undetectable		 4lb2A-3f9rA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feo MBT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02820
(MBT) 		4 LEU A 113
VAL A 114
PRO A 116
GLU A  50
 None
 0.98A 4lb2A-3feoA:
undetectable		 4lb2A-3feoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 VAL A 156
PRO A 154
GLU A 392
TYR A 426
 None
 1.03A 4lb2A-3fn9A:
undetectable		 4lb2A-3fn9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gz8 MUTT/NUDIX FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00293
(NUDIX) 		4 LEU A  73
VAL A  80
PRO A  82
TYR A 106
 None
 1.10A 4lb2A-3gz8A:
undetectable		 4lb2A-3gz8A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jys SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 270
LYS A 283
GLU A 284
TYR A 218
 None
 1.11A 4lb2A-3jysA:
undetectable		 4lb2A-3jysA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 LEU A 159
VAL A 136
PRO A 151
TYR A 215
 None
 0.77A 4lb2A-3okyA:
undetectable		 4lb2A-3okyA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 LEU A 159
VAL A 136
PRO A 151
TYR A 215
 None
 1.05A 4lb2A-3okyA:
undetectable		 4lb2A-3okyA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus) 		PF13649
(Methyltransf_25) 		4 VAL A 181
PRO A 121
TYR A  14
TYR A  15
 None
None
None
SAM  A 300 ( 3.5A)
 0.80A 4lb2A-3ou6A:
undetectable		 4lb2A-3ou6A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		4 LEU A 589
PRO A 579
GLU A 426
TYR A 497
 None
 0.88A 4lb2A-3p27A:
undetectable		 4lb2A-3p27A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 LEU A 230
VAL A 227
TYR A 214
GLU A 247
 None
 1.03A 4lb2A-3ps5A:
undetectable		 4lb2A-3ps5A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE

(Francisella
tularensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A  60
VAL A  59
PRO A  58
TYR A  46
 None
 1.11A 4lb2A-3qtyA:
undetectable		 4lb2A-3qtyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ud2 ANKYRIN-1

(Homo sapiens) 		no annotation 4 LEU C1121
VAL C1118
PRO C1114
GLU C1232
 None
 1.05A 4lb2A-3ud2C:
undetectable		 4lb2A-3ud2C:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuu ERYTHROCYTE MEMBRANE
PROTEIN, PUTATIVE

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 LEU A 203
VAL A 204
PRO A 206
LYS A 406
 None
 0.64A 4lb2A-3vuuA:
undetectable		 4lb2A-3vuuA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wi3 DNA REPLICATION
REGULATOR SLD3

(Saccharomyces
cerevisiae) 		PF08639
(SLD3) 		4 LEU A 266
VAL A 265
TYR A 166
TYR A 165
 EDO  A 504 ( 4.9A)
EDO  A 507 (-3.3A)
EDO  A 509 ( 4.6A)
None
 0.97A 4lb2A-3wi3A:
undetectable		 4lb2A-3wi3A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgx CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		4 LEU A1116
VAL A1115
LYS A1136
TYR A1138
 None
 1.04A 4lb2A-3zgxA:
undetectable		 4lb2A-3zgxA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 277
VAL A 278
PRO A 282
GLU A 216
 None
 1.11A 4lb2A-4a3rA:
undetectable		 4lb2A-4a3rA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 LEU A  57
VAL A  58
PRO A  60
GLU A 370
 None
 0.99A 4lb2A-4b90A:
undetectable		 4lb2A-4b90A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 LEU A  57
VAL A  58
PRO A  60
GLU A 370
 None
 1.00A 4lb2A-4b92A:
undetectable		 4lb2A-4b92A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df9 PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		4 PRO A 341
TYR A 324
GLU A 323
TYR A 386
 None
2PE  A 504 (-3.8A)
ZN  A 503 (-2.5A)
2PE  A 504 (-3.9A)
 1.10A 4lb2A-4df9A:
undetectable		 4lb2A-4df9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecl SERINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 300
VAL A 299
PRO A 307
GLU A 342
 None
 1.13A 4lb2A-4eclA:
undetectable		 4lb2A-4eclA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB

(Caldanaerobacter
subterraneus) 		PF01451
(LMWPc) 		4 LEU A 125
VAL A 127
GLU A  53
TYR A  59
 LEU  A 125 ( 0.6A)
VAL  A 127 ( 0.6A)
GLU  A  53 ( 0.6A)
TYR  A  59 ( 1.3A)
 1.06A 4lb2A-4egsA:
undetectable		 4lb2A-4egsA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB

(Caldanaerobacter
subterraneus) 		PF01451
(LMWPc) 		4 LEU A 125
VAL A 127
PRO A 120
GLU A  53
 LEU  A 125 ( 0.6A)
VAL  A 127 ( 0.6A)
PRO  A 120 ( 1.1A)
GLU  A  53 ( 0.6A)
 1.03A 4lb2A-4egsA:
undetectable		 4lb2A-4egsA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF12866
(DUF3823) 		4 LEU A 223
VAL A 194
PRO A 190
TYR A 200
 None
 0.90A 4lb2A-4fxtA:
undetectable		 4lb2A-4fxtA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz7 DIHYDROPYRIMIDINASE

(Tetraodon
nigroviridis) 		PF01979
(Amidohydro_1) 		4 LEU A  54
VAL A  55
PRO A  57
GLU A 367
 None
 0.99A 4lb2A-4gz7A:
undetectable		 4lb2A-4gz7A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0f LAMININ-BINDING
SURFACE PROTEIN

(Streptococcus
agalactiae) 		PF01297
(ZnuA) 		4 LEU A  83
VAL A  36
TYR A 172
GLU A 160
 None
 0.94A 4lb2A-4h0fA:
undetectable		 4lb2A-4h0fA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-RELATED
PROTEIN 7

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		4 LEU A  95
VAL A  97
PRO A  99
TYR A  89
 None
 1.09A 4lb2A-4i6mA:
undetectable		 4lb2A-4i6mA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4

(Saccharopolyspora
spinosa) 		PF08659
(KR) 		4 LEU A 116
VAL A  89
PRO A  91
GLU A 130
 None
 1.01A 4lb2A-4impA:
0.0		 4lb2A-4impA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix1 HYPOTHETICAL PROTEIN

(Rhodococcus
opacus) 		no annotation 4 LEU A  30
VAL A  33
PRO A  35
TYR A   9
 None
 0.95A 4lb2A-4ix1A:
undetectable		 4lb2A-4ix1A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 LEU A 101
VAL A 100
LYS A  46
TYR A  48
GLU A  50
 None
 1.28A 4lb2A-4j7qA:
undetectable		 4lb2A-4j7qA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 LEU A 730
VAL A 731
PRO A 733
TYR A 827
 None
 0.98A 4lb2A-4knhA:
undetectable		 4lb2A-4knhA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 LYS A 563
TYR A 564
GLU A 566
TYR A 516
 None
 1.10A 4lb2A-4m0mA:
undetectable		 4lb2A-4m0mA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Shewanella
loihica) 		PF03480
(DctP) 		4 LEU A  58
VAL A  59
TYR A 273
GLU A 269
 None
 0.87A 4lb2A-4o7mA:
undetectable		 4lb2A-4o7mA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		4 LEU A  54
VAL A  55
TYR A 270
GLU A 266
 None
 1.00A 4lb2A-4p47A:
undetectable		 4lb2A-4p47A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9d BENZOYLFORMATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 525
VAL A 526
PRO A 528
GLU A 512
 None
 1.13A 4lb2A-4q9dA:
undetectable		 4lb2A-4q9dA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwa SOLUBLE CYTOCHROME
B562,DELTA-TYPE
OPIOID RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 VAL A 196
PRO A 115
TYR A 109
GLU A 112
 None
 1.10A 4lb2A-4rwaA:
undetectable		 4lb2A-4rwaA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF13407
(Peripla_BP_4) 		4 LEU A 297
VAL A 296
GLU A 142
TYR A 172
 None
 1.06A 4lb2A-4ry0A:
undetectable		 4lb2A-4ry0A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmc OLD YELLOW ENZYME

(Kluyveromyces
marxianus) 		PF00724
(Oxidored_FMN) 		4 LEU A 287
VAL A 288
PRO A 290
TYR A 313
 None
FMN  A 501 ( 4.4A)
None
None
 0.95A 4lb2A-4tmcA:
undetectable		 4lb2A-4tmcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE IRON
PROTEIN 1

(Azotobacter
vinelandii) 		PF00142
(Fer4_NifH) 		4 LEU E 253
VAL E 254
PRO E 256
GLU E 146
 None
 1.03A 4lb2A-4wzbE:
undetectable		 4lb2A-4wzbE:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypl LON PROTEASE

(Meiothermus
taiwanensis) 		PF00004
(AAA)
PF05362
(Lon_C) 		4 LEU A 322
LYS A 498
GLU A 497
TYR A 505
 None
 0.81A 4lb2A-4yplA:
undetectable		 4lb2A-4yplA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 LEU A 194
LYS A 191
TYR A 190
GLU A 192
 None
 0.99A 4lb2A-5bn4A:
undetectable		 4lb2A-5bn4A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co8 NUCLEASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 PRO A 269
TYR A 276
GLU A 272
TYR A 277
 None
 1.05A 4lb2A-5co8A:
undetectable		 4lb2A-5co8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coa IRIDOID SYNTHASE

(Catharanthus
roseus) 		no annotation 4 LEU A  49
VAL A  48
LYS A  29
TYR A  28
 None
 0.97A 4lb2A-5coaA:
undetectable		 4lb2A-5coaA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H 124
PRO H 126
LYS L 136
GLU L 137
 None
 1.12A 4lb2A-5eorH:
undetectable		 4lb2A-5eorH:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2h UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF02230
(Abhydrolase_2) 		4 LEU A 159
TYR A 146
GLU A 144
TYR A 293
 None
 1.09A 4lb2A-5f2hA:
undetectable		 4lb2A-5f2hA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 LEU A 678
VAL A 725
PRO A 724
TYR A 693
 None
 1.11A 4lb2A-5f7sA:
undetectable		 4lb2A-5f7sA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 LEU B 328
VAL B 365
GLU B 443
TYR B 424
 None
 1.02A 4lb2A-5fq6B:
undetectable		 4lb2A-5fq6B:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0f HDAC6

(Danio rerio) 		PF02148
(zf-UBP) 		4 LEU A1018
VAL A1017
PRO A 998
GLU A1001
 None
 1.12A 4lb2A-5g0fA:
undetectable		 4lb2A-5g0fA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2g DIAMINOPIMELATE
EPIMERASE

(Corynebacterium
glutamicum) 		PF01678
(DAP_epimerase) 		4 VAL A 128
PRO A 266
LYS A 244
GLU A 253
 None
 1.07A 4lb2A-5h2gA:
undetectable		 4lb2A-5h2gA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7f TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Myxococcus
xanthus) 		PF00440
(TetR_N) 		4 VAL A 158
PRO A 156
LYS A 132
TYR A 134
 None
 0.83A 4lb2A-5k7fA:
2.5		 4lb2A-5k7fA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 LEU A 159
VAL A 136
PRO A 151
TYR A 215
 None
 0.84A 4lb2A-5l5gA:
0.2		 4lb2A-5l5gA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 LEU A 159
VAL A 136
PRO A 151
TYR A 215
 None
 0.96A 4lb2A-5l5gA:
0.2		 4lb2A-5l5gA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ll7 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 4 LEU A 122
VAL A 119
PRO A  94
TYR A 112
 None
 1.01A 4lb2A-5ll7A:
undetectable		 4lb2A-5ll7A:
9.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 4 LEU A 115
TYR A 137
GLU A 140
TYR A 160
 None
 1.04A 4lb2A-5oriA:
50.5		 4lb2A-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svd NUCLEOLAR PROTEIN 9

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		4 LEU A 406
VAL A 409
LYS A 433
TYR A 497
 LEU  A 406 ( 0.5A)
VAL  A 409 ( 0.6A)
LYS  A 433 ( 0.0A)
TYR  A 497 ( 1.3A)
 1.13A 4lb2A-5svdA:
undetectable		 4lb2A-5svdA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29

(Chaetomium
thermophilum) 		no annotation 4 LEU A  93
VAL A  94
PRO A  98
GLU A 104
 None
 1.09A 4lb2A-5w8mA:
undetectable		 4lb2A-5w8mA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN

(Pyrococcus
horikoshii) 		no annotation 4 LEU A 205
LYS A 202
TYR A 201
GLU A 203
 None
 0.99A 4lb2A-5x09A:
undetectable		 4lb2A-5x09A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcu VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA
VL-SARAH(S37C)
CHIMERA,VL-SARAH(S37
C) CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		4 LEU A  11
VAL A  12
PRO A  14
LYS B 148
 None
 1.10A 4lb2A-5xcuA:
undetectable		 4lb2A-5xcuA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcv VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA
VL-SARAH(S37C)
CHIMERA,VL-SARAH(S37
C) CHIMERA

(Homo sapiens;
Rattus) 		no annotation 4 LEU A  11
VAL A  12
PRO A  14
LYS B 148
 None
 1.04A 4lb2A-5xcvA:
undetectable		 4lb2A-5xcvA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 LEU A 158
VAL A 157
PRO A 308
TYR A 142
 None
 1.07A 4lb2A-5xdrA:
undetectable		 4lb2A-5xdrA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 4 VAL A 311
PRO A 309
LYS A 366
GLU A 364
 HFG  A 801 (-4.3A)
None
None
ANP  A 803 (-3.7A)
 1.02A 4lb2A-5xioA:
undetectable		 4lb2A-5xioA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh1 -

(-) 		no annotation 4 LEU A 333
VAL A 332
PRO A 486
GLU A 504
 None
 0.97A 4lb2A-5yh1A:
undetectable		 4lb2A-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 LEU A 115
PRO A 118
LYS A 137
TYR A 138
GLU A 141
 None
 1.01A 4lb2A-5yxeA:
46.9		 4lb2A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch7 BG18 LIGHT CHAIN

(Homo sapiens) 		no annotation 4 LEU R 136
VAL R 137
PRO R 123
LYS R 190
 None
 0.96A 4lb2A-6ch7R:
undetectable		 4lb2A-6ch7R:
8.24