SIMILAR PATTERNS OF AMINO ACIDS FOR 4LAR_L_1WEL300_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddd IMMUNOGENIC PROTEIN

(Ehrlichia
chaffeensis) 		PF16868
(NMT1_3) 		5 TYR A 237
SER A  93
TYR A 236
GLU A 124
TYR A  43
 None
None
None
None
GOL  A 405 (-3.8A)
 1.31A 4larH-4dddA:
0.0
4larL-4dddA:
0.0		 4larH-4dddA:
19.59
4larL-4dddA:
16.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gqp ANTI-METH SCFV

(Mus musculus) 		PF07686
(V-set) 		10 TYR H  33
SER H  35
TYR H  47
TYR H  50
PHE H  95
GLU H 101
TYR H1036
HIS H1089
TRP H1091
PHE H1096
 B40  H1201 (-3.7A)
B40  H1201 (-3.4A)
B40  H1201 (-4.6A)
B40  H1201 (-4.3A)
B40  H1201 (-3.7A)
B40  H1201 (-3.1A)
None
B40  H1201 (-4.1A)
B40  H1201 (-3.9A)
B40  H1201 ( 4.8A)
 0.22A 4larH-4gqpH:
25.1
4larL-4gqpH:
13.8		 4larH-4gqpH:
99.15
4larL-4gqpH:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		6 TYR H  33
SER H  35
TYR H  47
TYR H  50
PHE H  95
GLU H 101
 None
 0.69A 4larH-4laqH:
17.0
4larL-4laqH:
10.4		 4larH-4laqH:
100.00
4larL-4laqH:
26.67