SIMILAR PATTERNS OF AMINO ACIDS FOR 4LA0_B_198B601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 LEU A 134
PRO A 175
PHE A 194
GLU A 177
LEU A 145
 None
 1.45A 4la0B-1nneA:
0.0		 4la0B-1nneA:
25.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 LEU A 115
PRO A 118
ALA A 126
PHE A 134
GLU A 141
PHE A 165
LEU A 182
 None
 0.67A 4la0B-1tf0A:
48.1		 4la0B-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 PRO A 118
MET A 123
ALA A 126
PHE A 134
GLU A 141
PHE A 165
LEU A 182
 None
 0.43A 4la0B-1tf0A:
48.1		 4la0B-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 PRO A 118
MET A 123
ALA A 126
PHE A 134
PHE A 165
LEU A 178
 None
 1.49A 4la0B-1tf0A:
48.1		 4la0B-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		5 LEU A 489
ALA A 442
GLU A 455
PHE A 439
LEU A 481
 None
 1.41A 4la0B-1un9A:
0.0		 4la0B-1un9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7p VPS22, YPL002C
VPS36P, YLR417W

(Saccharomyces
cerevisiae) 		PF04157
(EAP30) 		5 LEU D 454
PRO D 457
MET A 140
GLU A  94
LEU A  76
 None
 1.32A 4la0B-1w7pD:
0.2		 4la0B-1w7pD:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1b CRTF-RELATED PROTEIN

(Chlorobaculum
tepidum) 		PF00891
(Methyltransf_2) 		5 LEU A 160
MET A 187
PHE A 191
GLU A 163
LEU A 271
 None
 1.41A 4la0B-1x1bA:
undetectable		 4la0B-1x1bA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zao RIO2 SERINE KINASE

(Archaeoglobus
fulgidus) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		5 LEU A 225
PRO A 167
ALA A 157
PHE A 236
PHE A 209
 None
ATP  A 286 ( 4.7A)
None
None
None
 1.41A 4la0B-1zaoA:
2.8		 4la0B-1zaoA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg5 FATTY ACID SYNTHASE
L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE

(Homo sapiens) 		PF00550
(PP-binding)
PF01648
(ACPS) 		5 LEU A 201
MET A 158
PHE A 162
PHE A 183
LEU B2157
 COA  A1300 (-3.9A)
None
None
None
None
 1.45A 4la0B-2cg5A:
0.5		 4la0B-2cg5A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 186
PRO A 168
ALA A 147
PHE A 148
LEU A 181
 None
 1.48A 4la0B-2id5A:
undetectable		 4la0B-2id5A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kjq DNAA-RELATED PROTEIN

(Neisseria
meningitidis) 		no annotation 5 MET A 139
ALA A 140
GLU A 133
PHE A 107
LEU A 103
 None
 1.25A 4la0B-2kjqA:
undetectable		 4la0B-2kjqA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lep RHOMBOID PROTEASE
GLPG 1

(Escherichia
coli) 		PF12122
(Rhomboid_N) 		5 MET A  20
ALA A  21
GLU A  42
PHE A  16
LEU A  52
 None
 1.42A 4la0B-2lepA:
undetectable		 4la0B-2lepA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		5 LEU A 339
ALA A  29
PHE A  15
PHE A  13
LEU A 441
 None
 1.28A 4la0B-2oodA:
undetectable		 4la0B-2oodA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		5 LEU A 372
ALA A  29
PHE A  15
PHE A  13
LEU A 441
 None
 1.09A 4la0B-2oodA:
undetectable		 4la0B-2oodA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox1 3-DEHYDROQUINATE
DEHYDRATASE

(Archaeoglobus
fulgidus) 		PF01487
(DHquinase_I) 		5 MET A  64
ALA A  67
GLU A  23
PHE A  89
LEU A  78
 None
 1.17A 4la0B-2ox1A:
undetectable		 4la0B-2ox1A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzq AXIN INTERACTOR,
DORSALIZATION
ASSOCIATED PROTEIN

(Danio rerio) 		PF14186
(Aida_C2) 		5 LEU A 168
MET A 126
ALA A 103
PHE A 106
LEU A 164
 None
 1.35A 4la0B-2qzqA:
undetectable		 4la0B-2qzqA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8o FLAVIVIRIN PROTEASE
NS3

(Murray Valley
encephalitis
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		5 LEU A 505
ALA A 312
PHE A 282
GLU A 309
LEU A 270
 None
 1.44A 4la0B-2v8oA:
undetectable		 4la0B-2v8oA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		5 PRO A  14
MET A  26
ALA A  28
PHE A  65
LEU A  43
 None
 1.26A 4la0B-3b4uA:
undetectable		 4la0B-3b4uA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8n UROPORPHYRINOGEN-III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		5 ALA A  88
LYS A  98
GLU A  99
PHE A  55
LEU A  66
 None
 1.27A 4la0B-3d8nA:
undetectable		 4la0B-3d8nA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1

(Drosophila
melanogaster) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 MET A  68
ALA A  71
GLU A 186
PHE A 205
LEU A 180
 None
 1.35A 4la0B-3dh9A:
2.6		 4la0B-3dh9A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gon PHOSPHOMEVALONATE
KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N) 		5 MET A 148
ALA A 152
PHE A 132
PHE A 165
LEU A 140
 None
 1.22A 4la0B-3gonA:
3.1		 4la0B-3gonA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE

(Rauvolfia
serpentina) 		PF00561
(Abhydrolase_1) 		5 PRO A 115
MET A  91
GLU A  98
PHE A  61
LEU A 192
 None
 1.20A 4la0B-3gzjA:
undetectable		 4la0B-3gzjA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1v PROTEIN INVG

(Salmonella
enterica) 		no annotation 5 PRO A  77
MET A  49
ALA A  50
PHE A  46
LEU A  84
 None
 1.48A 4la0B-3j1vA:
undetectable		 4la0B-3j1vA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8j 2-METHYLCITRATE
SYNTHASE

(Salmonella
enterica) 		PF00285
(Citrate_synt) 		5 LEU A  76
ALA A 198
PHE A  58
GLU A  60
LEU A  83
 None
 1.43A 4la0B-3o8jA:
undetectable		 4la0B-3o8jA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnt IMMUNITY FACTOR FOR
SPN

(Streptococcus
pyogenes) 		PF16718
(IFS) 		5 LEU B 102
PRO B 110
ALA B  61
GLU B  55
LEU B 113
 None
 1.17A 4la0B-3pntB:
undetectable		 4la0B-3pntB:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qb2 IMMUNITY FACTOR FOR
SPN

(Streptococcus
pyogenes) 		PF16718
(IFS) 		5 LEU A 102
PRO A 110
ALA A  61
GLU A  55
LEU A 113
 None
 1.17A 4la0B-3qb2A:
undetectable		 4la0B-3qb2A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qg5 RAD50

(Thermotoga
maritima) 		PF13476
(AAA_23)
PF13558
(SbcCD_C) 		5 LEU A 774
ALA A 837
PHE A 838
GLU A 817
PHE A 834
 None
 1.36A 4la0B-3qg5A:
4.1		 4la0B-3qg5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9o DIGUANYLATE CYCLASE
DGCZ

(Escherichia
coli) 		no annotation 5 MET A  75
ALA A  78
PHE A 113
PHE A  54
LEU A  15
 None
 1.40A 4la0B-3t9oA:
3.6		 4la0B-3t9oA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE

(Mus musculus) 		PF08645
(PNK3P)
PF13671
(AAA_33) 		5 ALA A 369
PHE A 449
GLU A 499
PHE A 380
LEU A 351
 None
 1.35A 4la0B-3u7gA:
undetectable		 4la0B-3u7gA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsj 2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
ALPHA SUBUNIT

(Comamonas
testosteroni) 		PF02900
(LigB) 		5 LEU A 177
ALA A   6
PHE A 269
PHE A 248
LEU A 217
 None
 1.34A 4la0B-3vsjA:
undetectable		 4la0B-3vsjA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		5 LEU A 333
ALA A 392
PHE A 324
PHE A 401
LEU A 311
 None
 1.32A 4la0B-4maeA:
undetectable		 4la0B-4maeA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		5 MET A  93
ALA A  92
GLU A 109
PHE A 202
LEU A 220
 None
 1.30A 4la0B-4mydA:
undetectable		 4la0B-4mydA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myn FORMIMINOGLUTAMASE

(Trypanosoma
cruzi) 		PF00491
(Arginase) 		5 MET A 256
ALA A 260
PHE A 225
PHE A 227
LEU A 248
 None
 1.41A 4la0B-4mynA:
undetectable		 4la0B-4mynA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 LEU A 587
MET A 544
GLU A 551
PHE A 604
LEU A 591
 None
 1.48A 4la0B-4nh0A:
undetectable		 4la0B-4nh0A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozv ALGINATE LYASE

(Pseudomonas
aeruginosa) 		PF05426
(Alginate_lyase) 		5 PRO A 263
ALA A 207
GLU A 246
PHE A 230
LEU A 286
 None
 1.45A 4la0B-4ozvA:
1.4		 4la0B-4ozvA:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		5 PRO A 118
ALA A 126
PHE A 134
GLU A 141
LEU A 182
 None
 0.68A 4la0B-4po0A:
47.4		 4la0B-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Leptospira
interrogans) 		PF00156
(Pribosyltran) 		5 LEU A  27
PRO A  59
GLU A  31
PHE A  40
LEU A  54
 None
 1.41A 4la0B-4qriA:
undetectable		 4la0B-4qriA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 PRO A 461
ALA A 632
PHE A 628
GLU A 594
LEU A 682
 None
 1.45A 4la0B-4tweA:
undetectable		 4la0B-4tweA:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 ALA A 125
PHE A 133
GLU A 140
PHE A 164
LEU A 181
 None
 0.49A 4la0B-5dqfA:
47.4		 4la0B-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwm HEAT SHOCK PROTEIN
HSP 90 BETA

(Homo sapiens) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 LEU A 343
ALA A 317
PHE A 429
PHE A 416
LEU A 374
 None
 1.41A 4la0B-5fwmA:
2.3		 4la0B-5fwmA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn1 INTERLEUKIN-37

(Homo sapiens) 		PF00340
(IL1) 		5 LEU A  77
PHE A  60
GLU A  89
PHE A 203
LEU A 167
 None
 1.49A 4la0B-5hn1A:
undetectable		 4la0B-5hn1A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A1185
ALA A1118
PHE A1145
PHE A1164
LEU A1178
 None
 1.48A 4la0B-5vkqA:
4.6		 4la0B-5vkqA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yv5 ATPASE RIL

(Pyrococcus
furiosus) 		no annotation 5 LEU A  90
PRO A 125
ALA A 140
PHE A 141
LEU A 119
 None
 1.41A 4la0B-5yv5A:
undetectable		 4la0B-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 8 LEU A 115
PRO A 118
MET A 123
ALA A 126
PHE A 134
LYS A 137
GLU A 141
PHE A 165
 None
 0.63A 4la0B-5yxeA:
46.6		 4la0B-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yzz B3 DOMAIN-CONTAINING
TRANSCRIPTION
REPRESSOR VAL1

(Arabidopsis
thaliana) 		no annotation 5 PRO C 313
ALA C 319
GLU C 296
PHE C 321
LEU C 359
 None
 1.08A 4la0B-5yzzC:
undetectable		 4la0B-5yzzC:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 5 LEU A1259
ALA A1073
LYS A1251
GLU A1252
LEU A1065
 None
 1.12A 4la0B-6fn1A:
undetectable		 4la0B-6fn1A:
7.85