SIMILAR PATTERNS OF AMINO ACIDS FOR 4LA0_A_198A601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)

(Aspergillus
nidulans) 		PF01761
(DHQ_synthase) 		5 LEU A  21
PRO A 138
MET A 144
ALA A 247
LEU A 180
 None
 1.20A 4la0A-1dqsA:
1.1		 4la0A-1dqsA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF02463
(SMC_N) 		5 LEU A1036
ARG A1117
ALA A1143
GLU A1124
LEU A1083
 None
 1.39A 4la0A-1e69A:
undetectable		 4la0A-1e69A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbv SIGNAL TRANSDUCTION
PROTEIN CBL

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3)
PF14447
(Prok-RING_4) 		5 ARG A 148
PRO A 147
GLU A 138
PHE A 133
LEU A  75
 None
 1.49A 4la0A-1fbvA:
2.6		 4la0A-1fbvA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmk SURFACTIN SYNTHETASE

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		5 LEU C 224
ARG C  40
ALA C  23
PHE C  77
LEU C 216
 None
 1.44A 4la0A-1jmkC:
undetectable		 4la0A-1jmkC:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		5 LEU A 459
ALA A 665
PHE A 467
GLU A 460
LEU A 188
 None
 1.47A 4la0A-1kehA:
0.2		 4la0A-1kehA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 LEU A 134
PRO A 175
PHE A 194
GLU A 177
LEU A 145
 None
 1.48A 4la0A-1nneA:
2.2		 4la0A-1nneA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF00899
(ThiF) 		5 ARG A 184
PRO A 188
ALA A 219
PHE A 196
GLU A 194
 None
 1.39A 4la0A-1r4nA:
2.1		 4la0A-1r4nA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 ARG A 117
PRO A 118
MET A 123
ALA A 126
PHE A 134
 None
 1.11A 4la0A-1tf0A:
47.9		 4la0A-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 LEU A 115
PRO A 118
ALA A 126
PHE A 134
GLU A 141
PHE A 165
LEU A 182
 None
 0.73A 4la0A-1tf0A:
47.9		 4la0A-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		8 PRO A 118
MET A 123
ALA A 126
PHE A 134
LYS A 137
GLU A 141
PHE A 165
LEU A 182
 None
 0.68A 4la0A-1tf0A:
47.9		 4la0A-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 PRO A 118
MET A 123
ALA A 126
PHE A 134
PHE A 165
LEU A 178
 None
 1.46A 4la0A-1tf0A:
47.9		 4la0A-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		5 LEU A 489
ALA A 442
GLU A 455
PHE A 439
LEU A 481
 None
 1.45A 4la0A-1un9A:
3.3		 4la0A-1un9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7p VPS22, YPL002C
VPS36P, YLR417W

(Saccharomyces
cerevisiae) 		PF04157
(EAP30) 		5 LEU D 454
PRO D 457
MET A 140
GLU A  94
LEU A  76
 None
 1.12A 4la0A-1w7pD:
undetectable		 4la0A-1w7pD:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		5 ARG A 121
MET A 102
GLU A 115
PHE A 106
LEU A 125
 None
 1.45A 4la0A-1yw6A:
undetectable		 4la0A-1yw6A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zao RIO2 SERINE KINASE

(Archaeoglobus
fulgidus) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		5 LEU A 225
PRO A 167
ALA A 157
PHE A 236
PHE A 209
 None
ATP  A 286 ( 4.7A)
None
None
None
 1.39A 4la0A-1zaoA:
2.5		 4la0A-1zaoA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv4 REGULATOR OF
G-PROTEIN SIGNALING
17

(Homo sapiens) 		PF00615
(RGS) 		5 LEU X 112
MET X 182
PHE X  98
GLU X 108
PHE X  85
 None
 1.33A 4la0A-1zv4X:
undetectable		 4la0A-1zv4X:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kjq DNAA-RELATED PROTEIN

(Neisseria
meningitidis) 		no annotation 5 MET A 139
ALA A 140
GLU A 133
PHE A 107
LEU A 103
 None
 1.27A 4la0A-2kjqA:
undetectable		 4la0A-2kjqA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		5 LEU A 372
ALA A  29
PHE A  15
PHE A  13
LEU A 441
 None
 1.11A 4la0A-2oodA:
undetectable		 4la0A-2oodA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox1 3-DEHYDROQUINATE
DEHYDRATASE

(Archaeoglobus
fulgidus) 		PF01487
(DHquinase_I) 		5 MET A  64
ALA A  67
GLU A  23
PHE A  89
LEU A  78
 None
 1.17A 4la0A-2ox1A:
undetectable		 4la0A-2ox1A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzq AXIN INTERACTOR,
DORSALIZATION
ASSOCIATED PROTEIN

(Danio rerio) 		PF14186
(Aida_C2) 		5 LEU A 168
MET A 126
ALA A 103
PHE A 106
LEU A 164
 None
 1.27A 4la0A-2qzqA:
undetectable		 4la0A-2qzqA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF13599
(Pentapeptide_4) 		5 LEU A 113
ALA A 122
PHE A 124
PHE A 144
LEU A 154
 LP6  A   2 ( 4.7A)
None
None
None
CL  A1213 (-4.9A)
 1.46A 4la0A-2w7zA:
undetectable		 4la0A-2w7zA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn7 OUTER SURFACE
PROTEIN

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		5 LEU A 393
ALA A 232
GLU A 300
PHE A 281
LEU A 368
 None
 1.49A 4la0A-2yn7A:
2.1		 4la0A-2yn7A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z87 CHONDROITIN SYNTHASE

(Escherichia
coli) 		PF00535
(Glycos_transf_2) 		5 LEU A 219
PHE A 333
GLU A 361
PHE A 340
LEU A 227
 UD2  A 683 (-3.7A)
None
UD2  A 683 (-3.6A)
None
None
 1.39A 4la0A-2z87A:
undetectable		 4la0A-2z87A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Thermus
thermophilus) 		PF01063
(Aminotran_4) 		5 PRO A  35
ALA A  94
GLU A  67
PHE A  83
LEU A  42
 None
 1.31A 4la0A-2zgiA:
undetectable		 4la0A-2zgiA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		5 PRO A  14
MET A  26
ALA A  28
PHE A  65
LEU A  43
 None
 1.40A 4la0A-3b4uA:
undetectable		 4la0A-3b4uA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1

(Drosophila
melanogaster) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 MET A  68
ALA A  71
GLU A 186
PHE A 205
LEU A 180
 None
 1.30A 4la0A-3dh9A:
undetectable		 4la0A-3dh9A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		5 LEU A 370
ARG A 369
MET A 228
ALA A 224
GLU A 242
 None
 1.36A 4la0A-3fdhA:
undetectable		 4la0A-3fdhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gon PHOSPHOMEVALONATE
KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N) 		5 MET A 148
ALA A 152
PHE A 132
PHE A 165
LEU A 140
 None
 1.30A 4la0A-3gonA:
2.4		 4la0A-3gonA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjz TRANSALDOLASE B

(Prochlorococcus
marinus) 		PF00923
(TAL_FSA) 		5 LEU A 244
PRO A 180
ALA A 167
GLU A 224
LEU A 239
 None
 1.41A 4la0A-3hjzA:
undetectable		 4la0A-3hjzA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvw DIGUANYLATE-CYCLASE
(DGC)

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		5 ARG A 231
ALA A 269
PHE A 270
GLU A 225
LEU A 239
 None
 1.28A 4la0A-3hvwA:
undetectable		 4la0A-3hvwA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		5 PRO B 890
ALA B 674
PHE B 676
PHE B 947
LEU B 943
 None
 1.42A 4la0A-3jb9B:
undetectable		 4la0A-3jb9B:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mes CHOLINE KINASE

(Cryptosporidium
parvum) 		PF01633
(Choline_kinase) 		5 ALA A 294
PHE A 363
GLU A 361
PHE A 260
LEU A 421
 None
 1.46A 4la0A-3mesA:
undetectable		 4la0A-3mesA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg9 TEG12

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		5 LEU A 267
ARG A  93
PRO A  92
GLU A 124
LEU A 253
 None
 1.29A 4la0A-3mg9A:
undetectable		 4la0A-3mg9A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgb TEG12

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		5 LEU A 267
ARG A  93
PRO A  92
GLU A 124
LEU A 253
 None
 1.29A 4la0A-3mgbA:
undetectable		 4la0A-3mgbA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8j 2-METHYLCITRATE
SYNTHASE

(Salmonella
enterica) 		PF00285
(Citrate_synt) 		5 LEU A  76
ALA A 198
PHE A  58
GLU A  60
LEU A  83
 None
 1.46A 4la0A-3o8jA:
undetectable		 4la0A-3o8jA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1u SUSD HOMOLOG

(Parabacteroides
distasonis) 		PF12741
(SusD-like) 		5 ARG A 408
ALA A 459
PHE A 384
GLU A 402
LEU A 424
 None
 1.30A 4la0A-3p1uA:
undetectable		 4la0A-3p1uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnt IMMUNITY FACTOR FOR
SPN

(Streptococcus
pyogenes) 		PF16718
(IFS) 		5 LEU B 102
PRO B 110
ALA B  61
GLU B  55
LEU B 113
 None
 1.20A 4la0A-3pntB:
undetectable		 4la0A-3pntB:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qb2 IMMUNITY FACTOR FOR
SPN

(Streptococcus
pyogenes) 		PF16718
(IFS) 		5 LEU A 102
PRO A 110
ALA A  61
GLU A  55
LEU A 113
 None
 1.20A 4la0A-3qb2A:
undetectable		 4la0A-3qb2A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		5 LEU A 202
PRO A 108
GLU A 175
PHE A 137
LEU A 181
 None
None
EPZ  A 518 ( 4.6A)
None
None
 1.42A 4la0A-3swgA:
undetectable		 4la0A-3swgA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9o DIGUANYLATE CYCLASE
DGCZ

(Escherichia
coli) 		no annotation 5 MET A  75
ALA A  78
PHE A 113
PHE A  54
LEU A  15
 None
 1.47A 4la0A-3t9oA:
3.7		 4la0A-3t9oA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE

(Mus musculus) 		PF08645
(PNK3P)
PF13671
(AAA_33) 		5 ALA A 369
PHE A 449
GLU A 499
PHE A 380
LEU A 351
 None
 1.38A 4la0A-3u7gA:
undetectable		 4la0A-3u7gA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsj 2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
ALPHA SUBUNIT

(Comamonas
testosteroni) 		PF02900
(LigB) 		5 LEU A 177
ALA A   6
PHE A 269
PHE A 248
LEU A 217
 None
 1.34A 4la0A-3vsjA:
undetectable		 4la0A-3vsjA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1

(Homo sapiens) 		PF04177
(TAP42) 		5 ARG A 171
MET A 175
ALA A 178
GLU A 187
LEU A 195
 None
 1.19A 4la0A-4iypA:
2.6		 4la0A-4iypA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrr THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA

(Legionella
pneumophila) 		PF01323
(DSBA) 		5 ALA A 157
PHE A 158
LYS A 137
PHE A 144
LEU A 123
 None
None
SO4  A 301 (-4.7A)
None
None
 1.05A 4la0A-4jrrA:
undetectable		 4la0A-4jrrA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kma GM14141P

(Drosophila
melanogaster) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		5 LEU A 427
ALA A 267
PHE A 374
PHE A 372
LEU A 360
 None
 1.29A 4la0A-4kmaA:
undetectable		 4la0A-4kmaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB

(Staphylococcus
epidermidis) 		PF00083
(Sugar_tr) 		5 PRO A 125
MET A 201
LYS A 212
GLU A 216
LEU A 189
 None
 1.44A 4la0A-4ldsA:
undetectable		 4la0A-4ldsA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		5 LEU A 333
ALA A 392
PHE A 324
PHE A 401
LEU A 311
 None
 1.28A 4la0A-4maeA:
undetectable		 4la0A-4maeA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		5 MET A  93
ALA A  92
GLU A 109
PHE A 202
LEU A 220
 None
 1.30A 4la0A-4mydA:
undetectable		 4la0A-4mydA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myn FORMIMINOGLUTAMASE

(Trypanosoma
cruzi) 		PF00491
(Arginase) 		5 MET A 256
ALA A 260
PHE A 225
PHE A 227
LEU A 248
 None
 1.39A 4la0A-4mynA:
undetectable		 4la0A-4mynA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozv ALGINATE LYASE

(Pseudomonas
aeruginosa) 		PF05426
(Alginate_lyase) 		5 PRO A 263
ALA A 207
GLU A 246
PHE A 230
LEU A 286
 None
 1.47A 4la0A-4ozvA:
1.4		 4la0A-4ozvA:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 ARG A 117
PRO A 118
ALA A 126
PHE A 134
GLU A 141
LEU A 182
 None
 0.74A 4la0A-4po0A:
50.1		 4la0A-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Leptospira
interrogans) 		PF00156
(Pribosyltran) 		5 LEU A  27
PRO A  59
GLU A  31
PHE A  40
LEU A  54
 None
 1.42A 4la0A-4qriA:
undetectable		 4la0A-4qriA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN

(Salmonella
enterica) 		PF13343
(SBP_bac_6) 		5 PRO A 157
MET A 167
ALA A 170
PHE A 171
LEU A 323
 None
 1.33A 4la0A-4r6yA:
undetectable		 4la0A-4r6yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 PRO A 461
ALA A 632
PHE A 628
GLU A 594
LEU A 682
 None
 1.48A 4la0A-4tweA:
undetectable		 4la0A-4tweA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8v CRISPR SYSTEM CMR
SUBUNIT CMR6

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		5 PHE A 211
LYS A 214
GLU A 218
PHE A 207
LEU A 161
 None
 1.48A 4la0A-4w8vA:
undetectable		 4la0A-4w8vA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)

(synthetic
construct) 		PF00079
(Serpin) 		5 LEU A 343
ALA A 336
PHE A 340
PHE A 263
LEU A 309
 None
 1.18A 4la0A-5ce0A:
undetectable		 4la0A-5ce0A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d28 GM-CSF/IL-2
INHIBITION FACTOR

(Orf virus) 		no annotation 5 ARG A 184
PRO A 185
ALA A 192
PHE A 229
LEU A 140
 None
 1.45A 4la0A-5d28A:
undetectable		 4la0A-5d28A:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 ALA A 125
PHE A 133
GLU A 140
PHE A 164
LEU A 181
 None
 0.51A 4la0A-5dqfA:
50.6		 4la0A-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwm HEAT SHOCK PROTEIN
HSP 90 BETA

(Homo sapiens) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 LEU A 343
ALA A 317
PHE A 429
PHE A 416
LEU A 374
 None
 1.45A 4la0A-5fwmA:
undetectable		 4la0A-5fwmA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghf AMINOTRANSFERASE
CLASS-III

(Ochrobactrum
anthropi) 		PF00202
(Aminotran_3) 		5 LEU A 365
PRO A 369
ALA A 452
GLU A 444
LEU A 385
 None
 1.15A 4la0A-5ghfA:
undetectable		 4la0A-5ghfA:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		5 ALA A 126
PHE A 134
LYS A 137
GLU A 141
PHE A 165
 None
 0.87A 4la0A-5ghkA:
47.4		 4la0A-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 5 LEU A 115
PHE A 133
LYS A 136
GLU A 140
PHE A 164
 None
 0.84A 4la0A-5oriA:
50.9		 4la0A-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swj PROBABLE ATP
SYNTHASE SPAL/MXIB

(Shigella
flexneri) 		PF00006
(ATP-synt_ab) 		5 LEU A 285
ARG A 154
PRO A 289
ALA A 245
LEU A 323
 None
 1.27A 4la0A-5swjA:
undetectable		 4la0A-5swjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 7 LEU A 115
PRO A 118
MET A 123
ALA A 126
PHE A 134
GLU A 141
PHE A 165
 None
 0.73A 4la0A-5yxeA:
45.9		 4la0A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 PRO A 118
MET A 123
PHE A 134
LYS A 137
PHE A 165
 None
 0.78A 4la0A-5yxeA:
45.9		 4la0A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yzz B3 DOMAIN-CONTAINING
TRANSCRIPTION
REPRESSOR VAL1

(Arabidopsis
thaliana) 		no annotation 5 PRO C 313
ALA C 319
GLU C 296
PHE C 321
LEU C 359
 None
 1.09A 4la0A-5yzzC:
undetectable		 4la0A-5yzzC:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zxd -

(-) 		no annotation 5 ALA A 400
PHE A 395
GLU A 470
PHE A 455
LEU A 483
 None
None
ATP  A 602 (-4.7A)
None
None
 1.38A 4la0A-5zxdA:
undetectable		 4la0A-5zxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 5 LEU A1231
ARG A1305
MET A1249
ALA A1253
PHE A1320
 None
 1.48A 4la0A-6bq1A:
undetectable		 4la0A-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwy DU-EDITING ENZYME
APOBEC-3G FUSION
PROTECTION OF
TELOMERES PROTEIN 1,
DNA DC->

(Homo sapiens;
Schizosaccharomyces
pombe) 		no annotation 5 LEU A 260
PRO A 287
ALA A 333
GLU A 294
LEU A 220
 None
 1.48A 4la0A-6bwyA:
undetectable		 4la0A-6bwyA:
9.55