SIMILAR PATTERNS OF AMINO ACIDS FOR 4L9Q_B_9TPB601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B

(Sorghum bicolor) 		PF00450
(Peptidase_S10) 		4 ARG B 420
GLU B 391
ASP B 357
ARG B 410
 None
 1.21A 4l9qB-1gxsB:
undetectable		 4l9qB-1gxsB:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Gallus gallus) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 ARG A  74
GLU A 123
ASP A  70
ARG A  69
 None
 1.46A 4l9qB-1ktcA:
0.0		 4l9qB-1ktcA:
20.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 ARG A 117
GLU A 141
ASP A 183
ARG A 186
 None
 0.98A 4l9qB-1tf0A:
47.7		 4l9qB-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5
REGULATOR OF
G-PROTEIN SIGNALING
9

(Mus musculus) 		PF00400
(WD40)
PF00610
(DEP)
PF00615
(RGS)
PF00631
(G-gamma) 		4 ARG A 207
GLU A 213
ASP B 259
ARG A  13
 None
 1.32A 4l9qB-2pbiA:
1.3		 4l9qB-2pbiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN

(Paracoccus
versutus) 		PF06433
(Me-amine-dh_H) 		4 ARG H 317
GLU H 311
ASP H 341
ARG H 340
 None
 1.35A 4l9qB-3c75H:
undetectable		 4l9qB-3c75H:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		4 ARG A 209
GLU A 245
ASP A 210
ARG A 213
 None
 1.42A 4l9qB-3r9bA:
0.2		 4l9qB-3r9bA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hly K9

(Human
gammaherpesvirus
8) 		PF00605
(IRF) 		4 ARG A 106
GLU A  90
ASP A  26
ARG A  31
 None
 1.38A 4l9qB-4hlyA:
0.0		 4l9qB-4hlyA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yai C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		4 ARG A  38
GLU A 204
ASP A  36
ARG A  62
 None
None
NAI  A 500 (-2.2A)
None
 1.20A 4l9qB-4yaiA:
0.0		 4l9qB-4yaiA:
18.24