SIMILAR PATTERNS OF AMINO ACIDS FOR 4L9Q_B_9TPB601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdr FLAVODOXIN REDUCTASE

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 LEU A 152
ILE A 168
LEU A 122
LEU A 125
LYS A 160
 None
 1.23A 4l9qB-1fdrA:
undetectable		 4l9qB-1fdrA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE

(Streptomyces
clavuligerus) 		PF00491
(Arginase) 		5 LEU A 261
ILE A  63
LEU A 301
LEU A 302
GLY A  65
 None
 1.18A 4l9qB-1gq7A:
undetectable		 4l9qB-1gq7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB

(Thermotoga
maritima) 		PF06723
(MreB_Mbl) 		5 LEU A  10
PRO A  64
ALA A  48
ILE A  84
GLY A 122
 None
 1.23A 4l9qB-1jcfA:
undetectable		 4l9qB-1jcfA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		5 PRO A  15
ILE A  10
HIS A 212
TYR A  31
LEU A  54
 None
 1.21A 4l9qB-1k1xA:
0.0		 4l9qB-1k1xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		5 LEU L 232
ALA L 212
ILE L 284
LEU L 116
GLY L 322
 None
 1.18A 4l9qB-1kfuL:
0.0		 4l9qB-1kfuL:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE

(Candida
tropicalis) 		PF01575
(MaoC_dehydratas) 		5 LEU A  21
HIS A  46
LEU A 176
LEU A 179
GLY A 181
 None
 1.19A 4l9qB-1pn4A:
undetectable		 4l9qB-1pn4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwy PEPTIDOGLYCAN
HYDROLASE

(Staphylococcus
aureus) 		PF01551
(Peptidase_M23) 		5 TYR A 258
ILE A 278
LEU A 192
LEU A 226
GLY A 275
 None
 1.18A 4l9qB-1qwyA:
undetectable		 4l9qB-1qwyA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF07732
(Cu-oxidase_3) 		5 ALA A  10
ILE A 230
TYR A 144
LEU A  62
LEU A 162
 None
 1.18A 4l9qB-1sddA:
undetectable		 4l9qB-1sddA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		9 LEU A 115
PRO A 118
TYR A 138
ILE A 142
HIS A 146
TYR A 161
LEU A 182
LEU A 185
GLY A 189
 None
 0.77A 4l9qB-1tf0A:
47.7		 4l9qB-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		9 LEU A 115
PRO A 118
TYR A 138
ILE A 142
TYR A 161
LEU A 182
LEU A 185
GLY A 189
LYS A 190
 None
 1.10A 4l9qB-1tf0A:
47.7		 4l9qB-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		9 PRO A 118
ALA A 126
TYR A 138
ILE A 142
HIS A 146
TYR A 161
LEU A 182
LEU A 185
GLY A 189
 None
 0.48A 4l9qB-1tf0A:
47.7		 4l9qB-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		9 PRO A 118
ALA A 126
TYR A 138
ILE A 142
TYR A 161
LEU A 182
LEU A 185
GLY A 189
LYS A 190
 None
 0.93A 4l9qB-1tf0A:
47.7		 4l9qB-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xup GLYCEROL KINASE

(Enterococcus
casseliflavus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ALA O 250
ILE O 195
HIS O 196
LEU O 288
GLY O 130
 None
 1.15A 4l9qB-1xupO:
undetectable		 4l9qB-1xupO:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a35 HYPOTHETICAL PROTEIN
PA4017

(Pseudomonas
aeruginosa) 		PF08732
(HIM1) 		5 LEU A 102
ILE A  66
LEU A  59
LEU A  62
GLY A  64
 None
 1.20A 4l9qB-2a35A:
undetectable		 4l9qB-2a35A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b44 GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM

(Staphylococcus
aureus) 		PF01551
(Peptidase_M23) 		5 TYR A 258
ILE A 278
LEU A 192
LEU A 226
GLY A 275
 None
 1.19A 4l9qB-2b44A:
undetectable		 4l9qB-2b44A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 PRO A1006
ILE A1346
LEU A1026
LEU A1029
GLY A1344
 None
 0.80A 4l9qB-2bruA:
undetectable		 4l9qB-2bruA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cex PROTEIN HI0146

(Haemophilus
influenzae) 		PF03480
(DctP) 		5 ALA A  78
LYS A 109
LEU A  53
LEU A  56
GLY A  59
 None
 1.15A 4l9qB-2cexA:
undetectable		 4l9qB-2cexA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4a MALATE DEHYDROGENASE

(Aeropyrum
pernix) 		no annotation 5 LEU B 229
ALA B 147
TYR B 246
ILE B 138
GLY B 271
 None
 1.11A 4l9qB-2d4aB:
undetectable		 4l9qB-2d4aB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfu PROBABLE
2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Thermus
thermophilus) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		5 LEU A 168
PRO A  83
LEU A  80
LEU A  78
GLY A  54
 None
 1.06A 4l9qB-2dfuA:
undetectable		 4l9qB-2dfuA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF00156
(Pribosyltran) 		5 LEU A  11
LYS A  39
TYR A  41
ILE A  45
LEU A  69
 None
 1.03A 4l9qB-2dy0A:
undetectable		 4l9qB-2dy0A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF00156
(Pribosyltran) 		5 LYS A  39
TYR A  41
ILE A  45
LEU A  69
GLY A  71
 None
 1.08A 4l9qB-2dy0A:
undetectable		 4l9qB-2dy0A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		5 ALA A 434
LYS A 383
ILE A  27
TYR A 407
GLY A  29
 None
 1.15A 4l9qB-2e0pA:
undetectable		 4l9qB-2e0pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ex5 DNA ENDONUCLEASE
I-CEUI

(Chlamydomonas
moewusii) 		PF00961
(LAGLIDADG_1) 		5 LEU A 123
LYS A  21
TYR A  36
LEU A 105
LEU A  37
 None
 1.21A 4l9qB-2ex5A:
undetectable		 4l9qB-2ex5A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A  34
PRO A  32
ILE A 184
LEU A  73
GLY A  75
 None
 0.97A 4l9qB-2fqdA:
undetectable		 4l9qB-2fqdA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		5 LEU A 132
PRO A 135
ALA A  80
LEU A 196
GLY A 111
 None
 0.96A 4l9qB-2fwrA:
undetectable		 4l9qB-2fwrA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ALA A 388
TYR A 408
LEU A 445
LEU A 416
GLY A 454
 None
 1.13A 4l9qB-2oipA:
undetectable		 4l9qB-2oipA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2peg HEMOGLOBIN SUBUNIT
BETA

(Trematomus
bernacchii) 		PF00042
(Globin) 		5 ALA B 116
ILE B  11
LEU B  68
LEU B  71
GLY B  74
 None
 1.15A 4l9qB-2pegB:
2.2		 4l9qB-2pegB:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70

(Saccharomyces
cerevisiae) 		PF03081
(Exo70) 		5 ALA A 356
ILE A 431
LEU A 507
LEU A 504
GLY A 500
 None
 1.01A 4l9qB-2pfvA:
2.4		 4l9qB-2pfvA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6t DNAB REPLICATION
FORK HELICASE

(Thermus
aquaticus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 LEU A 345
ALA A 217
ILE A 338
LEU A 379
GLY A 383
 None
 1.14A 4l9qB-2q6tA:
undetectable		 4l9qB-2q6tA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 LEU A 176
TYR A 188
ILE A 213
LEU A 169
GLY A 133
 None
 1.23A 4l9qB-2qedA:
undetectable		 4l9qB-2qedA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qib TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 LEU A  88
ALA A 191
ILE A 157
LEU A 140
LEU A 137
 P6G  A 703 (-4.0A)
None
P6G  A 701 ( 4.8A)
None
None
 1.14A 4l9qB-2qibA:
4.4		 4l9qB-2qibA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvg KINESIN-2

(Giardia
intestinalis) 		PF00225
(Kinesin) 		5 ALA A 101
TYR A 328
TYR A  96
LEU A 268
LEU A 271
 ADP  A1351 (-4.3A)
None
None
None
None
 1.15A 4l9qB-2vvgA:
undetectable		 4l9qB-2vvgA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 LEU A 581
ALA A 434
ILE A 571
HIS A 482
LEU A 469
 None
 1.18A 4l9qB-2xvgA:
undetectable		 4l9qB-2xvgA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4

(Homo sapiens) 		PF00443
(UCH) 		5 ILE A 447
HIS A 406
LEU A 398
LEU A 401
GLY A 404
 None
 1.03A 4l9qB-2y6eA:
undetectable		 4l9qB-2y6eA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 5 PRO A 136
ILE A 168
TYR A 193
LEU A 200
GLY A 273
 None
 1.01A 4l9qB-2zuxA:
undetectable		 4l9qB-2zuxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		5 PRO A 103
ILE A 135
TYR A 160
LEU A 167
GLY A 240
 None
 1.02A 4l9qB-2zuyA:
undetectable		 4l9qB-2zuyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		5 PRO A 499
ILE A 554
LEU A 504
LEU A 506
GLY A 543
 None
 1.23A 4l9qB-2zwaA:
undetectable		 4l9qB-2zwaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		5 ALA A 302
ILE A 273
LEU A 228
LEU A 231
GLY A 233
 None
 1.04A 4l9qB-3a6pA:
2.9		 4l9qB-3a6pA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1e BETAC-S LYASE

(Streptococcus
anginosus) 		PF00155
(Aminotran_1_2) 		5 LEU A 366
ALA A   9
ILE A 299
LEU A 205
GLY A 320
 None
 1.17A 4l9qB-3b1eA:
undetectable		 4l9qB-3b1eA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)

(Clostridium
acetobutylicum) 		PF13377
(Peripla_BP_3) 		5 LEU A 261
PRO A 290
ILE A 187
LEU A 255
GLY A 228
 None
 1.08A 4l9qB-3g85A:
undetectable		 4l9qB-3g85A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		5 LEU A 221
ALA A 167
ILE A 188
LEU A 214
GLY A 215
 None
 1.20A 4l9qB-3glbA:
undetectable		 4l9qB-3glbA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 LEU A1531
ALA A1596
ILE A1004
LEU A1661
GLY A1663
 None
 1.22A 4l9qB-3hmjA:
2.8		 4l9qB-3hmjA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixr BACTERIOFERRITIN
COMIGRATORY PROTEIN

(Xylella
fastidiosa) 		PF00578
(AhpC-TSA) 		5 ALA A  98
ILE A 133
LEU A  26
LEU A  34
GLY A 128
 None
 1.20A 4l9qB-3ixrA:
undetectable		 4l9qB-3ixrA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR

(Chlorobaculum
tepidum) 		PF13185
(GAF_2) 		5 ALA A  50
ILE A  91
HIS A 110
LEU A  61
GLY A 113
 None
 1.20A 4l9qB-3k2nA:
undetectable		 4l9qB-3k2nA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lre KINESIN-LIKE PROTEIN
KIF18A

(Homo sapiens) 		PF00225
(Kinesin) 		5 ALA A 117
TYR A 348
TYR A 112
LEU A 285
LEU A 288
 ADP  A 500 (-4.4A)
None
None
None
None
 1.14A 4l9qB-3lreA:
undetectable		 4l9qB-3lreA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lre KINESIN-LIKE PROTEIN
KIF18A

(Homo sapiens) 		PF00225
(Kinesin) 		5 LYS A 347
TYR A 348
TYR A 112
LEU A 285
LEU A 288
 None
 1.24A 4l9qB-3lreA:
undetectable		 4l9qB-3lreA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF00443
(UCH) 		5 ILE A 922
HIS A 881
LEU A 873
LEU A 876
GLY A 879
 None
 1.01A 4l9qB-3n3kA:
undetectable		 4l9qB-3n3kA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 LEU A 596
PRO A 599
ILE A 129
LEU A  88
GLY A  65
 None
 1.21A 4l9qB-3ogrA:
undetectable		 4l9qB-3ogrA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oos ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		5 LEU A  25
ILE A 118
TYR A 107
LEU A 103
GLY A 101
 None
 1.21A 4l9qB-3oosA:
undetectable		 4l9qB-3oosA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhd LACTALDEHYDE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00171
(Aldedh) 		5 ALA A  30
ILE A 318
LEU A 171
GLY A  85
LYS A  86
 None
 1.15A 4l9qB-3rhdA:
undetectable		 4l9qB-3rhdA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 PRO A 627
ALA A 618
ILE A 585
LEU A 588
LEU A 603
 None
 1.18A 4l9qB-3snhA:
1.7		 4l9qB-3snhA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 LEU A 428
ALA A 459
ILE A 448
LEU A 434
GLY A 451
 None
 1.22A 4l9qB-3szeA:
undetectable		 4l9qB-3szeA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ALA A  43
ILE A 212
TYR A 143
LEU A  67
LEU A 165
 None
 1.23A 4l9qB-3t9wA:
undetectable		 4l9qB-3t9wA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thu MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Sphingomonas
sp. SKA58) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 371
PRO A 365
ALA A 113
LEU A 296
GLY A 291
 None
 1.17A 4l9qB-3thuA:
undetectable		 4l9qB-3thuA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 LEU A 280
ILE A 319
LEU A 272
LEU A 266
GLY A 268
 None
 1.18A 4l9qB-3va6A:
undetectable		 4l9qB-3va6A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		5 ALA A 444
ILE A 287
LEU A 141
GLY A 149
LYS A 150
 None
 1.14A 4l9qB-4av6A:
undetectable		 4l9qB-4av6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		5 LEU A 408
ALA A 458
LYS A 597
LEU A 414
GLY A 542
 None
 1.13A 4l9qB-4bl3A:
undetectable		 4l9qB-4bl3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		5 TYR A 467
ILE A 520
HIS A 640
LEU A 458
GLY A 528
 None
 1.13A 4l9qB-4bq4A:
2.1		 4l9qB-4bq4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvt CYANURIC ACID
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF09663
(Amido_AtzD_TrzD) 		5 LEU A  67
ALA A  79
LEU A  20
LEU A  23
GLY A  27
 None
 1.03A 4l9qB-4bvtA:
undetectable		 4l9qB-4bvtA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		5 ALA V  10
ILE V 231
TYR V 145
LEU V  63
LEU V 163
 None
 1.20A 4l9qB-4bxsV:
undetectable		 4l9qB-4bxsV:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecl SERINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ALA A  39
LEU A   9
LEU A 247
GLY A 337
LYS A 338
 None
 1.15A 4l9qB-4eclA:
undetectable		 4l9qB-4eclA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fin ETTA (YJJK) ABCF
FAMILY PROTEIN

(Escherichia
coli) 		PF00005
(ABC_tran)
PF12848
(ABC_tran_Xtn) 		5 LEU A 176
PRO A 189
ILE A  71
LEU A  49
GLY A  54
 None
 1.22A 4l9qB-4finA:
undetectable		 4l9qB-4finA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2l BETA GLOBIN

(Peromyscus
maniculatus) 		PF00042
(Globin) 		5 LEU B  78
TYR B 130
LEU B  10
LEU B  14
GLY B  16
 None
 1.11A 4l9qB-4h2lB:
undetectable		 4l9qB-4h2lB:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzi ABC TRANSPORTER
ATP-BINDING PROTEIN

(Leptospira
interrogans) 		PF00005
(ABC_tran) 		5 ALA A 216
ILE A  82
LEU A  48
LEU A  51
GLY A  54
 None
 1.22A 4l9qB-4hziA:
undetectable		 4l9qB-4hziA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE

(Bombyx mori) 		PF00731
(AIRC)
PF01259
(SAICAR_synt) 		5 PRO A 347
ALA A 323
ILE A 285
HIS A 281
LEU A 385
 None
 1.17A 4l9qB-4ja0A:
2.1		 4l9qB-4ja0A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		5 LEU A 294
ALA A 209
ILE A 254
LEU A 275
GLY A 289
 None
 1.24A 4l9qB-4jccA:
undetectable		 4l9qB-4jccA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 LEU A 436
LYS A 380
TYR A 379
LEU A 450
GLY A 319
 None
 1.19A 4l9qB-4l68A:
undetectable		 4l9qB-4l68A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A 398
ALA A 475
LEU A 363
LEU A 464
GLY A 460
 None
 1.21A 4l9qB-4n78A:
2.6		 4l9qB-4n78A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 1

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 PRO A 280
ALA A 118
ILE A  63
LEU A   6
GLY A  67
 None
 1.06A 4l9qB-4nhdA:
undetectable		 4l9qB-4nhdA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei) 		PF02608
(Bmp) 		5 ALA A  51
ILE A 241
LEU A 143
LEU A 146
GLY A 148
 BR  A 412 ( 4.0A)
None
None
None
None
 1.00A 4l9qB-4p98A:
undetectable		 4l9qB-4p98A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		5 LEU B 275
ALA B 287
LEU B 239
LEU B 242
GLY B 245
 None
 1.20A 4l9qB-4peqB:
undetectable		 4l9qB-4peqB:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		5 LEU A 227
ALA A 192
LEU A 172
LEU A 177
GLY A 205
 None
 1.22A 4l9qB-4perA:
undetectable		 4l9qB-4perA:
24.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 PRO A 118
ALA A 126
HIS A 146
TYR A 161
LEU A 182
LEU A 185
 None
 0.83A 4l9qB-4po0A:
47.9		 4l9qB-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 PRO A 118
ALA A 126
TYR A 138
HIS A 146
TYR A 161
LEU A 182
 None
 0.91A 4l9qB-4po0A:
47.9		 4l9qB-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		5 PRO A 300
ALA A 310
ILE A 329
LEU A 275
GLY A 278
 None
 1.19A 4l9qB-4rsmA:
undetectable		 4l9qB-4rsmA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Staphylococcus
aureus) 		PF01380
(SIS) 		5 LEU A 430
ALA A 418
ILE A 267
LEU A 564
LEU A 567
 None
 1.17A 4l9qB-4s1wA:
undetectable		 4l9qB-4s1wA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tza FLUORESCENT PROTEIN

(synthetic
construct) 		no annotation 5 LEU C  42
ALA C 103
TYR C 116
ILE C  10
GLY C  31
 None
None
CRQ  C  62 ( 4.7A)
None
None
 1.24A 4l9qB-4tzaC:
undetectable		 4l9qB-4tzaC:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		6 PRO A  81
ALA A 141
ILE A 104
LEU A  50
LEU A 188
GLY A  89
 None
 1.40A 4l9qB-4xhbA:
undetectable		 4l9qB-4xhbA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ALA A 277
HIS A 341
LEU A 319
LEU A 349
GLY A 344
 None
 0.82A 4l9qB-4z0cA:
undetectable		 4l9qB-4z0cA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 PRO A 623
ALA A 614
ILE A 581
LEU A 584
LEU A 599
 None
 0.95A 4l9qB-5a3fA:
1.5		 4l9qB-5a3fA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqs 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Streptococcus
pneumoniae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 288
ALA A 260
TYR A 245
ILE A 298
GLY A 296
 None
 1.23A 4l9qB-5bqsA:
undetectable		 4l9qB-5bqsA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		5 LEU A 257
ALA A 284
ILE A 163
LEU A 176
LEU A 177
 None
 1.22A 4l9qB-5ck7A:
undetectable		 4l9qB-5ck7A:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		6 ALA A 125
TYR A 137
HIS A 145
TYR A 160
LEU A 181
LEU A 184
 None
 0.65A 4l9qB-5dqfA:
48.7		 4l9qB-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8v AMINOTRANSFERASE,
CLASS V FAMILY
PROTEIN

(Trichomonas
vaginalis) 		PF00266
(Aminotran_5) 		5 LEU A  62
PRO A 186
ALA A 272
ILE A 257
GLY A 205
 None
 1.17A 4l9qB-5f8vA:
undetectable		 4l9qB-5f8vA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 ALA A 126
TYR A 138
ILE A 142
HIS A 146
TYR A 161
LEU A 185
 None
 0.81A 4l9qB-5ghkA:
45.5		 4l9qB-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF11864
(DUF3384) 		5 LEU A 432
PRO A 442
ALA A 394
LEU A 405
GLY A 409
 LEU  A 432 ( 0.6A)
PRO  A 442 ( 1.1A)
ALA  A 394 ( 0.0A)
LEU  A 405 ( 0.5A)
GLY  A 409 ( 0.0A)
 1.23A 4l9qB-5hiuA:
undetectable		 4l9qB-5hiuA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase)
PF01261
(AP_endonuc_2)
PF14696
(Glyoxalase_5) 		5 PRO A 249
ALA A 255
HIS A 358
LEU A 448
GLY A 518
 None
 1.20A 4l9qB-5hmqA:
undetectable		 4l9qB-5hmqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ie2 OXALATE--COA LIGASE

(Arabidopsis
thaliana) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  61
ILE A  77
LEU A 168
LEU A 182
GLY A 164
 None
 0.89A 4l9qB-5ie2A:
undetectable		 4l9qB-5ie2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la7 HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		5 LEU A  92
ALA A 388
LEU A  80
LEU A  83
GLY A  86
 None
 1.13A 4l9qB-5la7A:
undetectable		 4l9qB-5la7A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE

(metagenome) 		no annotation 5 LEU A 237
PRO A 266
ILE A  98
LEU A 242
GLY A 100
 None
 1.20A 4l9qB-5nfqA:
undetectable		 4l9qB-5nfqA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF03009
(GDPD) 		5 LEU E  32
ALA E  61
TYR E 150
ILE E 186
GLY E 233
 None
 1.18A 4l9qB-5t9cE:
undetectable		 4l9qB-5t9cE:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 170
PRO A 173
ALA A 204
LEU A 331
LEU A 334
 None
None
CIT  A 401 (-4.0A)
None
None
 1.07A 4l9qB-5tnxA:
undetectable		 4l9qB-5tnxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 PRO A 302
ALA A 330
LEU A 356
LEU A 359
GLY A 362
 None
 1.22A 4l9qB-5tvjA:
undetectable		 4l9qB-5tvjA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 7 LEU A 115
PRO A 118
ALA A 126
LYS A 137
TYR A 138
HIS A 146
TYR A 161
 None
 0.95A 4l9qB-5yxeA:
46.2		 4l9qB-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 8 PRO A 118
ALA A 126
LYS A 137
TYR A 138
ILE A 142
HIS A 146
TYR A 161
LEU A 185
 None
 0.64A 4l9qB-5yxeA:
46.2		 4l9qB-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1

(Saccharomyces
cerevisiae) 		no annotation 5 PRO A 932
ALA A1000
TYR A 916
ILE A1089
GLY A1093
 None
 1.11A 4l9qB-6f42A:
undetectable		 4l9qB-6f42A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 5 LYS A2291
TYR A2290
ILE A2282
LEU A2461
GLY A2463
 None
 1.16A 4l9qB-6fb3A:
undetectable		 4l9qB-6fb3A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fht BACTERIOPHYTOCHROME,
ADENYLATE CYCLASE

(Deinococcus
radiodurans;
Synechocystis
sp. PCC 6803) 		no annotation 5 LEU A 370
PRO A 348
ALA A 501
LEU A 357
GLY A 361
 None
 1.22A 4l9qB-6fhtA:
undetectable		 4l9qB-6fhtA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)

(Homo sapiens) 		no annotation 5 ALA A 428
ILE A 281
LEU A 100
LEU A  97
GLY A  93
 None
 1.11A 4l9qB-6gctA:
2.0		 4l9qB-6gctA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)

(Homo sapiens) 		no annotation 5 LEU A 149
ALA A 157
LYS A 304
TYR A 305
HIS A 313
 None
 1.15A 4l9qB-6gctA:
2.0		 4l9qB-6gctA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B

(Sorghum bicolor) 		PF00450
(Peptidase_S10) 		4 ARG B 420
GLU B 391
ASP B 357
ARG B 410
 None
 1.21A 4l9qB-1gxsB:
undetectable		 4l9qB-1gxsB:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Gallus gallus) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 ARG A  74
GLU A 123
ASP A  70
ARG A  69
 None
 1.46A 4l9qB-1ktcA:
0.0		 4l9qB-1ktcA:
20.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 ARG A 117
GLU A 141
ASP A 183
ARG A 186
 None
 0.98A 4l9qB-1tf0A:
47.7		 4l9qB-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5
REGULATOR OF
G-PROTEIN SIGNALING
9

(Mus musculus) 		PF00400
(WD40)
PF00610
(DEP)
PF00615
(RGS)
PF00631
(G-gamma) 		4 ARG A 207
GLU A 213
ASP B 259
ARG A  13
 None
 1.32A 4l9qB-2pbiA:
1.3		 4l9qB-2pbiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN

(Paracoccus
versutus) 		PF06433
(Me-amine-dh_H) 		4 ARG H 317
GLU H 311
ASP H 341
ARG H 340
 None
 1.35A 4l9qB-3c75H:
undetectable		 4l9qB-3c75H:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		4 ARG A 209
GLU A 245
ASP A 210
ARG A 213
 None
 1.42A 4l9qB-3r9bA:
0.2		 4l9qB-3r9bA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hly K9

(Human
gammaherpesvirus
8) 		PF00605
(IRF) 		4 ARG A 106
GLU A  90
ASP A  26
ARG A  31
 None
 1.38A 4l9qB-4hlyA:
0.0		 4l9qB-4hlyA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yai C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		4 ARG A  38
GLU A 204
ASP A  36
ARG A  62
 None
None
NAI  A 500 (-2.2A)
None
 1.20A 4l9qB-4yaiA:
0.0		 4l9qB-4yaiA:
18.24