SIMILAR PATTERNS OF AMINO ACIDS FOR 4L9I_B_8PRB601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 161
VAL A 166
ALA A 179
LYS A 181
MET A 229
 None
 0.64A 4l9iB-1gzkA:
27.1		 4l9iB-1gzkA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  18
ALA A  31
LYS A  33
ASP A  86
LEU A 133
 None
 0.91A 4l9iB-1h4lA:
19.5		 4l9iB-1h4lA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		5 GLY A 406
VAL A 598
ALA A 596
ASP A 658
LEU A 661
 None
 1.06A 4l9iB-1i6qA:
undetectable		 4l9iB-1i6qA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 416
ALA A 428
LYS A 430
MET A 477
LEU A 528
 None
 0.72A 4l9iB-1k2pA:
21.8		 4l9iB-1k2pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 204
VAL A 209
ALA A 220
LYS A 222
MET A 269
LEU A 321
 None
 0.72A 4l9iB-1k9aA:
22.9		 4l9iB-1k9aA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 GLY A 207
VAL A 209
ALA A 220
MET A 269
LEU A 321
 None
 1.33A 4l9iB-1k9aA:
22.9		 4l9iB-1k9aA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF03623
(Focal_AT) 		5 VAL A 958
ALA A 935
MET A 939
ASP A1031
LEU A1028
 None
 1.47A 4l9iB-1ktmA:
4.8		 4l9iB-1ktmA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luj CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		5 GLY A 320
VAL A 325
ALA A 365
MET A 363
LEU A 388
 None
 1.18A 4l9iB-1lujA:
undetectable		 4l9iB-1lujA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 GLY A 214
VAL A 219
ALA A 230
LYS A 232
LEU A 340
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.4A)
 0.69A 4l9iB-1py5A:
17.2		 4l9iB-1py5A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 GLY A 287
VAL A 230
ALA A 228
LEU A 282
 None
None
NAG  A 812 (-4.9A)
None
 0.00A 4l9iB-1q5aA:
undetectable		 4l9iB-1q5aA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 GLY A 167
VAL A 172
ALA A 185
LYS A 187
LEU A 301
 ADP  A 810 (-3.0A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
ADP  A 810 (-4.7A)
 0.41A 4l9iB-1q8yA:
22.5		 4l9iB-1q8yA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 624
ALA A 642
LYS A 644
ASP A 698
LEU A 818
 None
 0.78A 4l9iB-1rjbA:
20.2		 4l9iB-1rjbA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  81
VAL A  86
ALA A  99
MET A 147
LEU A 201
 ATP  A 535 (-3.8A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 3.4A)
ATP  A 535 (-4.8A)
 0.77A 4l9iB-1s9iA:
23.0		 4l9iB-1s9iA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  86
ALA A  99
LYS A 101
MET A 147
MET A 150
LEU A 201
 ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
ATP  A 535 ( 3.4A)
None
ATP  A 535 (-4.8A)
 0.94A 4l9iB-1s9iA:
23.0		 4l9iB-1s9iA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 603
ALA A 621
LYS A 623
ASP A 677
LEU A 799
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
None
STI  A   3 (-4.4A)
 0.90A 4l9iB-1t46A:
21.1		 4l9iB-1t46A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 347
VAL A 352
ALA A 367
LYS A 369
MET A 414
 None
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
STU  A 100 (-3.6A)
 0.56A 4l9iB-1u59A:
24.1		 4l9iB-1u59A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 GLY A  37
VAL A  42
ALA A  55
LYS A  57
MET A 105
 None
 0.42A 4l9iB-1u5qA:
27.7		 4l9iB-1u5qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 VAL A  18
ALA A  30
LYS A  32
ASP A  85
LEU A 132
 None
 0.98A 4l9iB-1v0bA:
21.2		 4l9iB-1v0bA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpd TARTRONATE
SEMIALDEHYDE
REDUCTASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 GLY A 157
VAL A 136
ALA A 120
MET A  95
ASP A 150
 None
 0.92A 4l9iB-1vpdA:
undetectable		 4l9iB-1vpdA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf3 GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		5 GLY A  19
ALA A 136
MET A 137
ASP A 128
LEU A 127
 GNP  A 501 (-3.4A)
None
None
GNP  A 501 (-2.9A)
None
 1.45A 4l9iB-1wf3A:
undetectable		 4l9iB-1wf3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 GLY A 608
VAL A 613
ALA A 626
LYS A 628
MET A 788
 None
None
GOL  A 998 ( 3.7A)
None
GOL  A 998 ( 4.2A)
 0.69A 4l9iB-1zy4A:
16.6		 4l9iB-1zy4A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  22
VAL A  27
ALA A  40
LYS A  42
 None
None
GOL  A3001 (-3.5A)
None
 0.26A 4l9iB-2a2aA:
26.2		 4l9iB-2a2aA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY X  20
VAL X  25
ALA X  37
LYS X  39
LEU X 137
 None
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-4.4A)
 0.74A 4l9iB-2dq7X:
24.4		 4l9iB-2dq7X:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 GLY A  22
VAL A  27
ALA A  40
LYS A  42
ASP A  99
 ADP  A 500 ( 4.6A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
ADP  A 500 (-3.5A)
 1.00A 4l9iB-2f9gA:
25.0		 4l9iB-2f9gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 GLY A  25
VAL A  27
ALA A  40
MET A  96
LEU A 144
 ADP  A 500 (-3.8A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 (-4.3A)
 1.15A 4l9iB-2f9gA:
25.0		 4l9iB-2f9gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
LYS A  42
MET A  96
ASP A  99
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
ADP  A 500 (-3.5A)
ADP  A 500 (-4.3A)
 0.85A 4l9iB-2f9gA:
25.0		 4l9iB-2f9gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 GLY A  37
VAL A  42
ALA A  55
LYS A  57
MET A 105
 None
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
STU  A 400 ( 3.7A)
 0.50A 4l9iB-2gcdA:
27.7		 4l9iB-2gcdA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 GLY A  37
VAL A  42
ALA A  55
MET A 105
LEU A 158
 None
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 3.7A)
STU  A 400 ( 4.6A)
 0.77A 4l9iB-2gcdA:
27.7		 4l9iB-2gcdA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 281
ALA A 293
LYS A 295
MET A 341
LEU A 393
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-4.5A)
 0.83A 4l9iB-2h8hA:
20.6		 4l9iB-2h8hA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 GLY A  62
VAL A  67
ALA A  80
LYS A  82
MET A 129
 None
 0.63A 4l9iB-2hakA:
14.3		 4l9iB-2hakA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 GLY A 276
VAL A 281
ALA A 293
MET A 341
LEU A 393
 None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
 0.85A 4l9iB-2hckA:
20.7		 4l9iB-2hckA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 643
ALA A 659
LYS A 661
MET A 710
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 ( 4.7A)
 0.93A 4l9iB-2henA:
21.4		 4l9iB-2henA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 259
ALA A 271
LYS A 273
MET A 319
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-4.4A)
 0.79A 4l9iB-2hk5A:
20.1		 4l9iB-2hk5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 251
VAL A 256
ALA A 269
LYS A 271
LEU A 370
 None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.7A)
 0.70A 4l9iB-2hz0A:
22.0		 4l9iB-2hz0A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 351
VAL A 356
ALA A 369
LYS A 371
MET A 420
 None
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 ( 4.5A)
PDS  A 901 ( 4.8A)
 0.72A 4l9iB-2i0eA:
25.2		 4l9iB-2i0eA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 GLY A 431
VAL A 436
ALA A 452
LYS A 454
MET A 499
LEU A 553
 None
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.4A)
 0.90A 4l9iB-2j0jA:
20.9		 4l9iB-2j0jA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  32
VAL A  37
ALA A  50
LYS A  52
MET A  98
 None
QPP  A1314 ( 4.6A)
QPP  A1314 ( 3.7A)
None
QPP  A1314 ( 4.1A)
 0.31A 4l9iB-2jc6A:
17.2		 4l9iB-2jc6A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 436
ALA A 452
LYS A 454
MET A 499
LEU A 553
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
BII  A1687 (-4.1A)
BII  A1687 (-4.2A)
 0.88A 4l9iB-2jkmA:
20.6		 4l9iB-2jkmA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 596
ALA A 614
LYS A 616
ASP A 670
LEU A 785
 None
 0.77A 4l9iB-2ogvA:
20.9		 4l9iB-2ogvA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 GLY A 347
VAL A 352
ALA A 367
LYS A 369
MET A 414
LEU A 468
 ANP  A 615 (-3.6A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.76A 4l9iB-2ozoA:
19.8		 4l9iB-2ozoA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY X  73
VAL X  78
ALA X  91
LYS X  93
MET X 138
 F10  X 401 ( 4.1A)
None
F10  X 401 (-3.4A)
F10  X 401 (-4.3A)
F10  X 401 ( 4.0A)
 1.03A 4l9iB-2p3gX:
18.7		 4l9iB-2p3gX:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY X  73
VAL X  78
ALA X  91
MET X 138
LEU X 193
 F10  X 401 ( 4.1A)
None
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
F10  X 401 ( 4.4A)
 0.96A 4l9iB-2p3gX:
18.7		 4l9iB-2p3gX:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 GLY A  28
VAL A  33
ALA A  46
LYS A  48
LEU A 156
 ATP  A 381 (-3.0A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
ATP  A 381 ( 4.8A)
 0.71A 4l9iB-2phkA:
27.0		 4l9iB-2phkA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 GLY A  28
VAL A  33
ALA A  46
MET A 106
LEU A 156
 ATP  A 381 (-3.0A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
ATP  A 381 ( 4.8A)
 0.84A 4l9iB-2phkA:
27.0		 4l9iB-2phkA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ALA A  34
LYS A  36
MET A  85
ASP A  88
LEU A 140
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
None
None
 0.91A 4l9iB-2pmiA:
23.5		 4l9iB-2pmiA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 GLY X  37
ALA X  53
LYS X  55
MET X 120
LEU X 179
 None
HMD  X 400 (-3.5A)
HMD  X 400 (-4.2A)
None
HMD  X 400 (-4.7A)
 0.72A 4l9iB-2pmoX:
26.3		 4l9iB-2pmoX:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		6 GLY B  50
VAL B  55
ALA B  67
LYS B  69
MET B 117
LEU B 171
 None
 0.89A 4l9iB-2qkwB:
17.2		 4l9iB-2qkwB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ree CURA

(Moorea
producens) 		PF00583
(Acetyltransf_1) 		5 GLY A 414
VAL A 417
ALA A 394
ASP A 383
LEU A 381
 None
 1.21A 4l9iB-2reeA:
undetectable		 4l9iB-2reeA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  46
LYS A  71
MET A 131
ASP A 137
LEU A 184
 None
 1.04A 4l9iB-2rsvA:
14.9		 4l9iB-2rsvA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  47
LYS A  71
MET A 131
ASP A 137
LEU A 184
 None
 1.15A 4l9iB-2rsvA:
14.9		 4l9iB-2rsvA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  85
ALA A 103
LYS A 105
MET A 153
MET A 156
ASP A 160
LEU A 205
 ANP  A1480 ( 3.8A)
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
ANP  A1480 (-4.1A)
None
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
 0.90A 4l9iB-2v55A:
28.0		 4l9iB-2v55A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  85
VAL A  90
ALA A 103
LYS A 105
MET A 153
ASP A 160
LEU A 205
 ANP  A1480 ( 3.8A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
ANP  A1480 (-4.1A)
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
 0.81A 4l9iB-2v55A:
28.0		 4l9iB-2v55A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  88
VAL A  90
ALA A 103
LYS A 105
MET A 153
 None
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
ANP  A1480 (-4.1A)
 1.25A 4l9iB-2v55A:
28.0		 4l9iB-2v55A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  80
VAL A  85
ALA A  98
LYS A 100
MET A 148
 None
BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
BI8  A1417 (-4.2A)
BI8  A1417 (-4.1A)
 0.72A 4l9iB-2vd5A:
31.6		 4l9iB-2vd5A:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		6 GLY A 493
VAL A 498
ALA A 509
LYS A 511
ASP A 611
LEU A 656
 None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
5ID  A1800 (-3.6A)
5ID  A1800 (-4.5A)
 0.92A 4l9iB-2vuwA:
15.6		 4l9iB-2vuwA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  55
VAL A  60
ALA A  73
LYS A  75
 None
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
None
 0.25A 4l9iB-2w4oA:
20.5		 4l9iB-2w4oA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY B  15
VAL B  20
ALA B  33
ASP B  99
LEU B 147
 None
 1.05A 4l9iB-2w9fB:
18.4		 4l9iB-2w9fB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY C  58
VAL C  63
ALA C  76
LYS C  78
MET C 129
LEU C 183
 ANP  C   2 (-3.0A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
None
 0.77A 4l9iB-2wtkC:
29.0		 4l9iB-2wtkC:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 229
VAL A 234
ALA A 247
MET A 304
LEU A 354
 None
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.6A)
 0.50A 4l9iB-2xk9A:
22.8		 4l9iB-2xk9A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 232
VAL A 234
ALA A 247
MET A 304
LEU A 354
 None
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.6A)
 1.06A 4l9iB-2xk9A:
22.8		 4l9iB-2xk9A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 234
ALA A 247
LYS A 249
MET A 304
LEU A 354
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
None
XK9  A1511 (-4.6A)
 1.10A 4l9iB-2xk9A:
22.8		 4l9iB-2xk9A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  33
VAL A  38
ALA A  51
LYS A  53
MET A 110
LEU A 160
 None
None
B49  A1294 (-3.2A)
None
None
B49  A1294 (-4.4A)
 0.89A 4l9iB-2y7jA:
28.3		 4l9iB-2y7jA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		4 GLY A  22
VAL A  27
ALA A  40
LYS A  42
 AMP  A1302 ( 4.6A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
 0.23A 4l9iB-2yabA:
20.4		 4l9iB-2yabA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		5 GLY A 319
VAL A 324
ALA A 364
MET A 362
LEU A 387
 None
 1.14A 4l9iB-2z6gA:
undetectable		 4l9iB-2z6gA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		5 GLY A 320
VAL A 325
ALA A 365
MET A 363
LEU A 388
 None
 1.15A 4l9iB-2z6hA:
undetectable		 4l9iB-2z6hA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  71
VAL A  76
ALA A  92
ASP A 148
LEU A 194
 STU  A   1 ( 4.1A)
None
STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
STU  A   1 (-4.6A)
 0.89A 4l9iB-2z7rA:
28.4		 4l9iB-2z7rA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  76
ALA A  92
LYS A  94
ASP A 148
LEU A 194
 None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-3.8A)
STU  A   1 (-4.6A)
 0.78A 4l9iB-2z7rA:
28.4		 4l9iB-2z7rA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A1005
VAL A1010
ALA A1028
MET A1076
MET A1079
 None
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.9A)
None
 0.98A 4l9iB-2z8cA:
20.5		 4l9iB-2z8cA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A1010
ALA A1028
MET A1076
MET A1079
ASP A1083
 S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.9A)
None
S91  A   1 (-3.7A)
 0.94A 4l9iB-2z8cA:
20.5		 4l9iB-2z8cA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A1010
LYS A1030
MET A1076
MET A1079
ASP A1083
 S91  A   1 ( 4.9A)
S91  A   1 ( 4.2A)
S91  A   1 ( 4.9A)
None
S91  A   1 (-3.7A)
 1.06A 4l9iB-2z8cA:
20.5		 4l9iB-2z8cA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 534
VAL A 539
ALA A 551
LYS A 553
MET A 602
ASP A 608
 None
None
None
7PE  A   1 (-2.6A)
7PE  A   1 ( 4.3A)
None
 0.79A 4l9iB-2zmcA:
21.9		 4l9iB-2zmcA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 539
ALA A 551
MET A 602
ASP A 608
LEU A 654
 None
None
7PE  A   1 ( 4.3A)
None
None
 1.04A 4l9iB-2zmcA:
21.9		 4l9iB-2zmcA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 261
ALA A 273
LYS A 275
MET A 322
ASP A 329
 None
 1.19A 4l9iB-2zv7A:
23.5		 4l9iB-2zv7A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 261
ALA A 273
LYS A 275
MET A 322
LEU A 374
 None
 0.71A 4l9iB-2zv7A:
23.5		 4l9iB-2zv7A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 490
VAL A 495
ALA A 515
LYS A 517
LEU A 633
 M33  A1996 (-3.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 (-4.5A)
 0.83A 4l9iB-3b2tA:
19.5		 4l9iB-3b2tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A1087
VAL A1092
ALA A1108
MET A1160
ASP A1164
 None
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
None
CKK  A1500 (-3.7A)
 0.92A 4l9iB-3c1xA:
17.0		 4l9iB-3c1xA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  34
ALA A  52
LYS A  54
MET A 107
LEU A 167
 None
 1.49A 4l9iB-3coiA:
21.5		 4l9iB-3coiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  34
ALA A  52
LYS A  54
MET A 107
MET A 110
ASP A 113
 None
 1.09A 4l9iB-3coiA:
21.5		 4l9iB-3coiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  34
VAL A  39
ALA A  52
MET A 107
LEU A 167
 None
 1.16A 4l9iB-3coiA:
21.5		 4l9iB-3coiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  34
VAL A  39
ALA A  52
MET A 107
MET A 110
ASP A 113
 None
 0.84A 4l9iB-3coiA:
21.5		 4l9iB-3coiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 204
VAL A 209
ALA A 220
LYS A 222
MET A 269
LEU A 321
 None
 0.72A 4l9iB-3d7uA:
6.7		 4l9iB-3d7uA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 207
VAL A 209
ALA A 220
MET A 269
LEU A 321
 None
 1.33A 4l9iB-3d7uA:
6.7		 4l9iB-3d7uA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 153
VAL A 158
ALA A 169
LYS A 171
MET A 220
 SO4  A8001 ( 4.3A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 (-3.7A)
 1.05A 4l9iB-3dtcA:
19.7		 4l9iB-3dtcA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 153
VAL A 158
ALA A 169
MET A 220
LEU A 275
 SO4  A8001 ( 4.3A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.7A)
VIN  A6331 (-4.5A)
 0.63A 4l9iB-3dtcA:
19.7		 4l9iB-3dtcA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  35
VAL A  40
ALA A  53
LYS A  55
MET A 108
LEU A 168
 None
35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
35F  A   1 ( 4.6A)
35F  A   1 ( 3.9A)
35F  A   1 (-4.5A)
 1.13A 4l9iB-3e7oA:
21.8		 4l9iB-3e7oA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 GLY A  18
VAL A  23
ALA A  36
LYS A  38
MET A 117
 None
None
DRK  A 384 (-3.5A)
None
DRK  A 384 (-3.8A)
 0.57A 4l9iB-3eb0A:
24.3		 4l9iB-3eb0A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  47
VAL A  52
ALA A  65
LYS A  67
ASP A 128
 None
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.7A)
 0.87A 4l9iB-3f2aA:
23.0		 4l9iB-3f2aA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  52
ALA A  65
LYS A  67
ASP A 128
LEU A 174
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.7A)
985  A   1 (-4.8A)
 0.92A 4l9iB-3f2aA:
23.0		 4l9iB-3f2aA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 GLY A  37
VAL A  42
ALA A  55
LYS A  57
MET A 102
LEU A 155
 None
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
DRK  A   1 (-3.6A)
DRK  A   1 (-4.6A)
 0.86A 4l9iB-3f3zA:
22.1		 4l9iB-3f3zA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 GLY A  65
VAL A  70
ALA A  83
MET A 132
 None
 0.22A 4l9iB-3fe3A:
18.6		 4l9iB-3fe3A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  62
ALA A  80
MET A 129
MET A 132
LEU A 186
 None
STU  A   1 (-3.4A)
STU  A   1 ( 3.8A)
None
STU  A   1 (-4.4A)
 0.85A 4l9iB-3fmeA:
21.7		 4l9iB-3fmeA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  62
VAL A  67
ALA A  80
LYS A  82
MET A 129
 None
None
STU  A   1 (-3.4A)
STU  A   1 ( 4.2A)
STU  A   1 ( 3.8A)
 0.42A 4l9iB-3fmeA:
21.7		 4l9iB-3fmeA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  62
VAL A  67
ALA A  80
MET A 129
LEU A 186
 None
None
STU  A   1 (-3.4A)
STU  A   1 ( 3.8A)
STU  A   1 (-4.4A)
 0.67A 4l9iB-3fmeA:
21.7		 4l9iB-3fmeA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		5 GLY A 298
VAL A 273
ALA A 308
MET A 309
ASP A 265
 None
None
None
AHZ  A1100 (-3.3A)
None
 1.44A 4l9iB-3fpzA:
undetectable		 4l9iB-3fpzA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 212
VAL A 217
ALA A 228
LYS A 230
MET A 279
LEU A 340
 ADP  A 900 (-3.0A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
 0.65A 4l9iB-3g2fA:
22.4		 4l9iB-3g2fA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 GLY A  19
VAL A  24
ALA A  37
LYS A  39
MET A  89
LEU A 182
 ANP  A 329 (-3.3A)
ANP  A 329 (-4.4A)
ANP  A 329 ( 3.7A)
ANP  A 329 (-2.7A)
ANP  A 329 (-3.7A)
ANP  A 329 (-4.4A)
 0.77A 4l9iB-3hkoA:
25.9		 4l9iB-3hkoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens) 		PF00514
(Arm) 		5 GLY A 311
VAL A 316
ALA A 356
MET A 354
LEU A 379
 None
 1.16A 4l9iB-3ifqA:
2.2		 4l9iB-3ifqA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 GLY A  85
VAL A  90
ALA A 103
LYS A 105
LEU A 205
 ANP  A 610 (-2.9A)
ANP  A 610 (-3.9A)
ANP  A 610 ( 3.7A)
ANP  A 610 (-2.8A)
None
 0.73A 4l9iB-3igoA:
17.3		 4l9iB-3igoA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y MS30

(Homo sapiens) 		PF00829
(Ribosomal_L21p) 		5 VAL s 284
ALA s 338
MET s 341
ASP s  77
LEU s  80
 None
 1.45A 4l9iB-3j7ys:
undetectable		 4l9iB-3j7ys:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		5 GLY A  31
VAL A 123
ALA A 142
MET A 139
ASP A  71
 None
 1.44A 4l9iB-3ju1A:
undetectable		 4l9iB-3ju1A:
22.37