SIMILAR PATTERNS OF AMINO ACIDS FOR 4L9I_A_8PRA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  41
ALA A  54
LEU A  58
MET A 109
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.3A)
None
ANP  A 400 (-4.6A)
 0.62A 4l9iA-1cm8A:
10.4		 4l9iA-1cm8A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 VAL A 166
ALA A 179
LEU A 183
MET A 229
 None
 0.26A 4l9iA-1gzkA:
9.5		 4l9iA-1gzkA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 VAL A 900
ALA A 913
LEU A 909
LEU A 888
 None
 0.79A 4l9iA-1h0hA:
0.0		 4l9iA-1h0hA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jye LACTOSE OPERON
REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		5 VAL A  99
ALA A 106
LEU A 114
ASP A 149
LEU A 128
 None
 1.40A 4l9iA-1jyeA:
0.0		 4l9iA-1jyeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 416
ALA A 428
MET A 477
LEU A 528
 None
 0.67A 4l9iA-1k2pA:
10.0		 4l9iA-1k2pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 209
ALA A 220
MET A 269
LEU A 321
 None
 0.64A 4l9iA-1k9aA:
9.0		 4l9iA-1k9aA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		4 ALA A 606
MET A 657
ASP A 661
LEU A 731
 None
 0.81A 4l9iA-1lufA:
8.2		 4l9iA-1lufA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  78
ALA A  91
LEU A  95
MET A 138
 STU  A 401 (-4.7A)
STU  A 401 (-3.4A)
None
STU  A 401 (-3.2A)
 0.51A 4l9iA-1nxkA:
7.1		 4l9iA-1nxkA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  78
ALA A  91
MET A 138
LEU A 193
 STU  A 401 (-4.7A)
STU  A 401 (-3.4A)
STU  A 401 (-3.2A)
STU  A 401 (-4.7A)
 0.77A 4l9iA-1nxkA:
7.1		 4l9iA-1nxkA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 VAL A 145
ALA A 148
LEU A 126
ASP A  42
LEU A 198
 None
 1.20A 4l9iA-1oywA:
0.0		 4l9iA-1oywA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51

(Pyrococcus
furiosus) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 VAL A 313
ALA A 325
LEU A 333
LEU A 147
 None
 0.81A 4l9iA-1pznA:
undetectable		 4l9iA-1pznA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qap QUINOLINIC ACID
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 VAL A 112
ALA A  81
LEU A 106
ASP A  33
LEU A  30
 None
 1.21A 4l9iA-1qapA:
undetectable		 4l9iA-1qapA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 624
ALA A 642
ASP A 698
LEU A 818
 None
 0.56A 4l9iA-1rjbA:
7.8		 4l9iA-1rjbA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  86
ALA A  99
MET A 147
MET A 150
 ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 3.4A)
None
 0.79A 4l9iA-1s9iA:
8.1		 4l9iA-1s9iA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  86
ALA A  99
MET A 150
LEU A 201
 ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
None
ATP  A 535 (-4.8A)
 0.60A 4l9iA-1s9iA:
8.1		 4l9iA-1s9iA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqe HYPOTHETICAL PROTEIN
PG130

(Staphylococcus
aureus) 		PF03992
(ABM) 		4 VAL A 113
ALA A  20
LEU A  24
LEU A  83
 None
 0.82A 4l9iA-1sqeA:
undetectable		 4l9iA-1sqeA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 603
ALA A 621
ASP A 677
LEU A 799
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
None
STI  A   3 (-4.4A)
 0.79A 4l9iA-1t46A:
7.9		 4l9iA-1t46A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlf LAC REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		5 VAL A  99
ALA A 106
LEU A 114
ASP A 149
LEU A 128
 None
None
None
IPT  A 998 (-3.2A)
None
 1.39A 4l9iA-1tlfA:
undetectable		 4l9iA-1tlfA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 352
ALA A 367
MET A 414
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-4.5A)
 0.58A 4l9iA-1u59A:
9.5		 4l9iA-1u59A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 VAL A  42
ALA A  55
MET A 105
LEU A 158
 None
 0.52A 4l9iA-1u5qA:
10.1		 4l9iA-1u5qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 VAL A  18
ALA A  30
ASP A  85
LEU A 132
 None
 0.69A 4l9iA-1v0bA:
8.7		 4l9iA-1v0bA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		4 VAL A 297
ALA A 317
LEU A 338
LEU A 221
 None
 0.79A 4l9iA-1v4vA:
undetectable		 4l9iA-1v4vA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wk0 KIAA0970 PROTEIN

(Homo sapiens) 		PF00041
(fn3) 		4 VAL A  62
ALA A  97
ASP A  88
LEU A  89
 None
 0.81A 4l9iA-1wk0A:
undetectable		 4l9iA-1wk0A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 VAL A 893
ALA A 857
ASP A 758
LEU A 759
 None
 0.81A 4l9iA-1x9nA:
undetectable		 4l9iA-1x9nA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6x ADP-RIBOSYLATION
FACTOR 4

(Homo sapiens) 		PF00025
(Arf) 		4 VAL A 155
ALA A 125
LEU A 121
ASP A 141
 None
 0.73A 4l9iA-1z6xA:
undetectable		 4l9iA-1z6xA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z INTERCELLULAR
ADHESION MOLECULE-1

(Homo sapiens) 		PF03921
(ICAM_N) 		4 VAL I 265
ALA I 221
LEU I 225
ASP I 213
 None
 0.76A 4l9iA-1z7zI:
undetectable		 4l9iA-1z7zI:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 VAL A 259
ALA A 272
ASP A 330
LEU A 376
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-4.3A)
BI1  A1000 (-4.8A)
 0.63A 4l9iA-1zrzA:
12.9		 4l9iA-1zrzA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abk ENDONUCLEASE III

(Escherichia
coli) 		PF00633
(HHH)
PF00730
(HhH-GPD)
PF10576
(EndIII_4Fe-2S) 		4 VAL A 125
ALA A 129
LEU A  37
ASP A 107
 None
 0.82A 4l9iA-2abkA:
undetectable		 4l9iA-2abkA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdq COPPER HOMEOSTASIS
PROTEIN CUTC

(Streptococcus
agalactiae) 		PF03932
(CutC) 		4 ALA A  58
LEU A  17
MET A  60
ASP A  29
 None
 0.82A 4l9iA-2bdqA:
undetectable		 4l9iA-2bdqA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		4 VAL A 273
ALA A 270
ASP A 226
LEU A 256
 None
 0.80A 4l9iA-2eaeA:
undetectable		 4l9iA-2eaeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 VAL A  27
ALA A  40
MET A  96
ASP A  99
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 (-3.5A)
ADP  A 500 (-4.3A)
 0.89A 4l9iA-2f9gA:
7.5		 4l9iA-2f9gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 VAL A  42
ALA A  55
MET A 105
LEU A 158
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 3.7A)
STU  A 400 ( 4.6A)
 0.59A 4l9iA-2gcdA:
11.1		 4l9iA-2gcdA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 281
ALA A 293
MET A 341
LEU A 393
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-4.5A)
 0.73A 4l9iA-2h8hA:
7.5		 4l9iA-2h8hA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2

(Salmonella
enterica) 		PF04166
(PdxA) 		5 VAL A 155
ALA A 288
LEU A 322
ASP A 261
LEU A 195
 None
 1.41A 4l9iA-2hi1A:
undetectable		 4l9iA-2hi1A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 259
ALA A 271
MET A 319
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-4.4A)
 0.82A 4l9iA-2hk5A:
10.2		 4l9iA-2hk5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 VAL A 356
ALA A 369
LEU A 373
MET A 420
 PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
None
PDS  A 901 ( 4.8A)
 0.58A 4l9iA-2i0eA:
13.3		 4l9iA-2i0eA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 VAL A 436
ALA A 452
MET A 499
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.4A)
 0.64A 4l9iA-2j0jA:
9.1		 4l9iA-2j0jA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  18
ALA A  31
ASP A  86
LEU A 134
 None
 0.82A 4l9iA-2jgzA:
10.1		 4l9iA-2jgzA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 436
ALA A 452
MET A 499
LEU A 553
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-4.1A)
BII  A1687 (-4.2A)
 0.76A 4l9iA-2jkmA:
7.6		 4l9iA-2jkmA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 VAL A 899
ALA A 629
LEU A 633
LEU A 353
 None
 0.72A 4l9iA-2obeA:
undetectable		 4l9iA-2obeA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 596
ALA A 614
ASP A 670
LEU A 785
 None
 0.56A 4l9iA-2ogvA:
7.1		 4l9iA-2ogvA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 VAL A 352
ALA A 367
MET A 414
LEU A 468
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.49A 4l9iA-2ozoA:
9.3		 4l9iA-2ozoA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL X  78
ALA X  91
LEU X  95
MET X 138
 None
F10  X 401 (-3.4A)
None
F10  X 401 ( 4.0A)
 0.76A 4l9iA-2p3gX:
6.6		 4l9iA-2p3gX:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL X  78
ALA X  91
MET X 138
LEU X 193
 None
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
F10  X 401 ( 4.4A)
 0.72A 4l9iA-2p3gX:
6.6		 4l9iA-2p3gX:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 VAL A  33
ALA A  46
MET A 106
LEU A 156
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
ATP  A 381 ( 4.8A)
 0.73A 4l9iA-2phkA:
23.0		 4l9iA-2phkA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		4 VAL B  55
ALA B  67
MET B 117
LEU B 171
 None
 0.73A 4l9iA-2qkwB:
19.3		 4l9iA-2qkwB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		4 ALA A 111
LEU A 115
ASP A  60
LEU A  56
 None
 0.83A 4l9iA-2qvwA:
undetectable		 4l9iA-2qvwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 103
LEU A 107
MET A 153
MET A 156
 ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.1A)
None
 0.82A 4l9iA-2v55A:
12.1		 4l9iA-2v55A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 103
MET A 153
MET A 156
ASP A 160
LEU A 205
 ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
None
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
 0.63A 4l9iA-2v55A:
12.1		 4l9iA-2v55A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  90
ALA A 103
LEU A 107
MET A 153
 None
ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.1A)
 0.46A 4l9iA-2v55A:
12.1		 4l9iA-2v55A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  90
ALA A 103
MET A 153
ASP A 160
LEU A 205
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
 0.73A 4l9iA-2v55A:
12.1		 4l9iA-2v55A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  85
ALA A  98
ASP A 155
LEU A 202
 BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
None
BI8  A1417 (-4.8A)
 0.80A 4l9iA-2vd5A:
9.6		 4l9iA-2vd5A:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  85
ALA A  98
MET A 148
LEU A 202
 BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
BI8  A1417 (-4.1A)
BI8  A1417 (-4.8A)
 0.79A 4l9iA-2vd5A:
9.6		 4l9iA-2vd5A:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL C  63
ALA C  76
LEU C  80
MET C 129
LEU C 183
 ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
 0.90A 4l9iA-2wtkC:
24.5		 4l9iA-2wtkC:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 VAL A 301
ALA A 380
LEU A 376
MET A 307
 None
 0.80A 4l9iA-2x58A:
undetectable		 4l9iA-2x58A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  34
ALA A  47
MET A  95
LEU A 147
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.39A 4l9iA-2xikA:
24.9		 4l9iA-2xikA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 234
ALA A 247
MET A 304
LEU A 354
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.6A)
 0.51A 4l9iA-2xk9A:
22.7		 4l9iA-2xk9A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  38
ALA A  51
MET A 110
LEU A 160
 None
B49  A1294 (-3.2A)
None
B49  A1294 (-4.4A)
 0.59A 4l9iA-2y7jA:
12.0		 4l9iA-2y7jA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypd PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		4 VAL A2193
LEU A2460
ASP A2373
LEU A2376
 None
 0.75A 4l9iA-2ypdA:
undetectable		 4l9iA-2ypdA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2x TK-SUBTILISIN

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		4 VAL A 279
ALA A 260
MET A 233
ASP A 240
 None
 0.68A 4l9iA-2z2xA:
undetectable		 4l9iA-2z2xA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		4 VAL A 279
ALA A 260
MET A 233
ASP A 240
 None
 0.52A 4l9iA-2z2zA:
undetectable		 4l9iA-2z2zA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  76
ALA A  92
ASP A 148
LEU A 194
 None
STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
STU  A   1 (-4.6A)
 0.65A 4l9iA-2z7rA:
11.7		 4l9iA-2z7rA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A1010
ALA A1028
MET A1076
MET A1079
ASP A1083
 S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.9A)
None
S91  A   1 (-3.7A)
 0.90A 4l9iA-2z8cA:
20.9		 4l9iA-2z8cA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 539
ALA A 551
MET A 602
ASP A 608
LEU A 654
 None
None
7PE  A   1 ( 4.3A)
None
None
 0.96A 4l9iA-2zmcA:
8.7		 4l9iA-2zmcA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zt9 CYTOCHROME B6
CYTOCHROME B6-F
COMPLEX SUBUNIT 4

(Nostoc sp. PCC
7120) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 VAL A 151
ALA A 147
LEU A 169
LEU B  81
 None
 0.82A 4l9iA-2zt9A:
2.5		 4l9iA-2zt9A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 261
ALA A 273
MET A 322
LEU A 374
 None
 0.74A 4l9iA-2zv7A:
8.9		 4l9iA-2zv7A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  39
MET A  94
ASP A  98
LEU A 148
 3AM  A 338 (-3.3A)
None
None
3AM  A 338 (-4.7A)
 0.58A 4l9iA-3c0iA:
11.9		 4l9iA-3c0iA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  26
ALA A  39
MET A  94
LEU A 148
 3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
None
3AM  A 338 (-4.7A)
 0.76A 4l9iA-3c0iA:
11.9		 4l9iA-3c0iA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbg O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF01596
(Methyltransf_3) 		4 VAL A 203
ALA A 217
MET A 166
ASP A 196
 None
 0.83A 4l9iA-3cbgA:
undetectable		 4l9iA-3cbgA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  39
ALA A  52
LEU A  56
MET A 107
LEU A 167
 None
 1.27A 4l9iA-3coiA:
8.2		 4l9iA-3coiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  39
ALA A  52
MET A 107
MET A 110
ASP A 113
 None
 0.81A 4l9iA-3coiA:
8.2		 4l9iA-3coiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 209
ALA A 220
MET A 269
LEU A 321
 None
 0.64A 4l9iA-3d7uA:
9.0		 4l9iA-3d7uA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 158
ALA A 169
MET A 220
LEU A 275
 VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.7A)
VIN  A6331 (-4.5A)
 0.40A 4l9iA-3dtcA:
7.6		 4l9iA-3dtcA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 VAL A  37
ALA A  50
MET A 100
LEU A 153
 None
 0.49A 4l9iA-3dxnA:
8.8		 4l9iA-3dxnA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  40
ALA A  53
LEU A  57
MET A 108
 35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
None
35F  A   1 ( 3.9A)
 0.76A 4l9iA-3e7oA:
8.4		 4l9iA-3e7oA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  52
ALA A  65
ASP A 128
LEU A 174
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 (-4.7A)
985  A   1 (-4.8A)
 0.77A 4l9iA-3f2aA:
22.2		 4l9iA-3f2aA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 VAL A  42
ALA A  55
MET A 102
LEU A 155
 DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-3.6A)
DRK  A   1 (-4.6A)
 0.44A 4l9iA-3f3zA:
25.1		 4l9iA-3f3zA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  80
MET A 129
MET A 132
LEU A 186
 STU  A   1 (-3.4A)
STU  A   1 ( 3.8A)
None
STU  A   1 (-4.4A)
 0.65A 4l9iA-3fmeA:
8.6		 4l9iA-3fmeA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  67
ALA A  80
MET A 129
LEU A 186
 None
STU  A   1 (-3.4A)
STU  A   1 ( 3.8A)
STU  A   1 (-4.4A)
 0.63A 4l9iA-3fmeA:
8.6		 4l9iA-3fmeA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 217
ALA A 228
MET A 279
LEU A 340
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
 0.69A 4l9iA-3g2fA:
18.5		 4l9iA-3g2fA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 VAL A  24
ALA A  37
MET A  89
LEU A 182
 ANP  A 329 (-4.4A)
ANP  A 329 ( 3.7A)
ANP  A 329 (-3.7A)
ANP  A 329 (-4.4A)
 0.47A 4l9iA-3hkoA:
22.9		 4l9iA-3hkoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwk METHYLCITRATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		5 VAL A  59
LEU A  75
MET A 294
ASP A 288
LEU A 331
 None
 1.50A 4l9iA-3hwkA:
undetectable		 4l9iA-3hwkA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 VAL A  76
ALA A  89
MET A 138
LEU A 191
 ANP  A 522 (-4.1A)
ANP  A 522 (-3.6A)
ANP  A 522 ( 4.4A)
ANP  A 522 (-4.7A)
 0.74A 4l9iA-3lijA:
11.1		 4l9iA-3lijA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  47
ALA A  60
LEU A  64
LEU A 165
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
None
None
 0.69A 4l9iA-3lm5A:
9.2		 4l9iA-3lm5A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A1031
MET A1079
MET A1082
ASP A1086
 None
CCX  A   1 ( 3.9A)
None
None
 0.70A 4l9iA-3lw0A:
8.3		 4l9iA-3lw0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A1013
ALA A1031
MET A1079
ASP A1086
 None
None
CCX  A   1 ( 3.9A)
None
 0.73A 4l9iA-3lw0A:
8.3		 4l9iA-3lw0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 179
ALA A 192
ASP A 246
LEU A 293
 FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-4.2A)
 0.79A 4l9iA-3mtlA:
7.5		 4l9iA-3mtlA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  57
ALA A  70
LEU A  74
MET A 120
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 ( 4.0A)
 0.25A 4l9iA-3mvjA:
12.1		 4l9iA-3mvjA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  57
ALA A  70
MET A 120
LEU A 173
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 (-4.6A)
 0.66A 4l9iA-3mvjA:
12.1		 4l9iA-3mvjA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		4 VAL A 197
ALA A 195
ASP A 318
LEU A 319
 None
 0.82A 4l9iA-3mwgA:
undetectable		 4l9iA-3mwgA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 VAL A  37
ALA A  49
MET A 101
ASP A 104
LEU A 151
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
ADP  A 314 (-4.1A)
ADP  A 314 (-4.6A)
 0.78A 4l9iA-3nizA:
9.0		 4l9iA-3nizA:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 VAL A 200
ALA A 213
LEU A 217
MET A 266
ASP A 270
LEU A 318
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 (-3.6A)
AMP  A 577 (-4.8A)
 0.99A 4l9iA-3nyoA:
40.4		 4l9iA-3nyoA:
44.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH) 		4 VAL A 164
ALA A 177
LEU A 181
MET A 227
 VAL  A 164 ( 0.6A)
ALA  A 177 ( 0.0A)
LEU  A 181 ( 0.6A)
MET  A 227 ( 0.0A)
 0.28A 4l9iA-3o96A:
9.2		 4l9iA-3o96A:
29.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ALA A  38
MET A  93
ASP A  96
LEU A 141
 None
 0.82A 4l9iA-3oz6A:
8.4		 4l9iA-3oz6A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		4 VAL A 356
ALA A 369
LEU A 373
MET A 420
 ANP  A 800 ( 4.7A)
ANP  A 800 (-3.6A)
None
ANP  A 800 (-4.8A)
 0.76A 4l9iA-3pfqA:
22.8		 4l9iA-3pfqA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qa8 MGC80376 PROTEIN

(Xenopus laevis) 		PF00069
(Pkinase) 		4 VAL A  29
ALA A  42
MET A  96
ASP A 103
 None
 0.68A 4l9iA-3qa8A:
5.9		 4l9iA-3qa8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  90
ALA A 103
LEU A 107
MET A 153
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.6A)
NM7  A 416 (-3.6A)
 0.42A 4l9iA-3qfvA:
24.6		 4l9iA-3qfvA:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  90
ALA A 103
MET A 153
ASP A 160
LEU A 207
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
NM7  A 416 (-3.6A)
None
NM7  A 416 ( 4.2A)
 0.76A 4l9iA-3qfvA:
24.6		 4l9iA-3qfvA:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  58
ALA A  71
LEU A  75
MET A 118
MET A 121
 I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
None
I85  A 350 ( 3.9A)
None
 0.93A 4l9iA-3sheA:
6.9		 4l9iA-3sheA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  58
ALA A  71
MET A 118
MET A 121
LEU A 173
 I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 ( 3.9A)
None
None
 0.65A 4l9iA-3sheA:
6.9		 4l9iA-3sheA:
23.24