SIMILAR PATTERNS OF AMINO ACIDS FOR 4L8W_I_MTXI301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1l9x GAMMA-GLUTAMYL
HYDROLASE

(Homo sapiens) 		PF07722
(Peptidase_C26) 		6 GLY A  73
CYH A 110
LEU A 111
GLU A 114
HIS A 171
TRP A 173
 None
 0.49A 4l8wI-1l9xA:
47.7		 4l8wI-1l9xA:
53.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 PHE A 259
GLY A 266
GLY A 261
HIS A 215
GLN A 218
 None
 1.18A 4l8wI-1ve1A:
1.4		 4l8wI-1ve1A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc3 PUTATIVE
FRUCTOKINASE

(Bacillus
subtilis) 		PF00480
(ROK) 		5 GLY A  21
GLY A 279
LEU A 281
HIS A 285
GLN A 286
 None
 1.14A 4l8wI-1xc3A:
0.7		 4l8wI-1xc3A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp1 FII

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 PHE A 129
GLY A  71
GLY A 109
LEU A 110
GLN A  96
 None
 1.28A 4l8wI-1yp1A:
0.6		 4l8wI-1yp1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egm TRIPARTITE
MOTIF-CONTAINING
PROTEIN 41

(Homo sapiens) 		PF00643
(zf-B_box) 		5 GLY A  19
CYH A  40
LEU A  28
HIS A  24
GLN A  25
 None
ZN  A 200 (-2.3A)
None
ZN  A 200 (-3.0A)
None
 1.25A 4l8wI-2egmA:
undetectable		 4l8wI-2egmA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2evr COG0791: CELL
WALL-ASSOCIATED
HYDROLASES
(INVASION-ASSOCIATED
PROTEINS)

(Nostoc
punctiforme) 		PF00877
(NLPC_P60) 		5 PHE A  26
CYH A  60
LEU A  59
GLU A  61
HIS A  43
 None
 1.27A 4l8wI-2evrA:
undetectable		 4l8wI-2evrA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdn ELONGATION FACTOR
EF-TU

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 PHE B 374
GLY B 317
GLY B 384
LEU B 311
GLU B 315
 None
 1.22A 4l8wI-2hdnB:
1.4		 4l8wI-2hdnB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 PHE A1374
GLY A1317
GLY A1384
LEU A1311
GLU A1315
 None
 1.21A 4l8wI-3mmpA:
3.1		 4l8wI-3mmpA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		5 PHE A 659
GLY A 602
GLY A 669
LEU A 596
GLU A 600
 None
 1.10A 4l8wI-4fwtA:
4.2		 4l8wI-4fwtA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0q ELONGATION FACTOR
TU-A

(Pseudomonas
putida) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 PHE A 378
GLY A 321
GLY A 388
LEU A 315
GLU A 319
 None
 1.27A 4l8wI-4j0qA:
4.4		 4l8wI-4j0qA:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l95 GAMMA-GLUTAMYL
HYDROLASE

(Danio rerio) 		no annotation 5 GLY E  72
LEU E 109
GLU E 112
GLN E 170
TRP E 171
 None
 1.19A 4l8wI-4l95E:
51.9		 4l8wI-4l95E:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l95 GAMMA-GLUTAMYL
HYDROLASE

(Danio rerio) 		no annotation 9 PHE E  20
GLY E  71
GLY E  73
CYH E 108
LEU E 109
GLU E 112
HIS E 169
GLN E 170
TRP E 171
 None
 0.45A 4l8wI-4l95E:
51.9		 4l8wI-4l95E:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 PHE A 386
GLY A 329
GLY A 396
LEU A 323
GLU A 327
 None
 1.34A 4l8wI-4lbwA:
4.9		 4l8wI-4lbwA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4q ELONGATION FACTOR TU

(Escherichia
coli) 		PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 PHE C 375
GLY C 318
GLY C 385
LEU C 312
GLU C 316
 None
 1.17A 4l8wI-5i4qC:
undetectable		 4l8wI-5i4qC:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 5 PHE A 375
GLY A 318
GLY A 385
LEU A 312
GLU A 316
 None
 1.22A 4l8wI-5w76A:
3.7		 4l8wI-5w76A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7q CONSENSUS ELONGATION
FACTOR

(synthetic
construct) 		no annotation 5 PHE A 375
GLY A 318
GLY A 385
LEU A 312
GLU A 316
 None
 1.30A 4l8wI-5w7qA:
4.0		 4l8wI-5w7qA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehe OMPT PROTEIN

(Vibrio cholerae) 		no annotation 5 PHE A 302
GLY A 290
GLY A 288
LEU A 268
GLU A 252
 None
 1.34A 4l8wI-6eheA:
undetectable		 4l8wI-6eheA:
15.38