SIMILAR PATTERNS OF AMINO ACIDS FOR 4L7I_B_SAMB501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)


(Lactobacillus
sp. 30A)
PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C)
5 ASN A 222
ARG A 220
ASP A 258
LEU A 241
ILE A 306
None
1.10A 4l7iA-1c4kA:
0.0
4l7iA-1c4kA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c6v PROTEIN (SIV
INTEGRASE)


(Simian
immunodeficiency
virus)
PF00665
(rve)
4 HIS A 156
ASN A 160
ASP A 163
ILE A 162
None
1.05A 4l7iA-1c6vA:
0.0
4l7iA-1c6vA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbv GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 ASN O 152
LEU O 324
ASN O 146
ILE O 144
None
1.04A 4l7iA-1dbvO:
0.0
4l7iA-1dbvO:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f02 INTIMIN
TRANSLOCATED INTIMIN
RECEPTOR


(Escherichia
coli;
Escherichia
coli)
PF02368
(Big_2)
PF02369
(Big_1)
PF07979
(Intimin_C)
PF03549
(Tir_receptor_M)
4 ASP T 302
ASN I 921
ASP I 916
ILE I 897
None
1.07A 4l7iA-1f02T:
undetectable
4l7iA-1f02T:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum)
PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim)
4 ASN A  78
ARG A 281
ASP A 102
ILE A  83
None
0.77A 4l7iA-1fohA:
0.0
4l7iA-1fohA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g2p ADENINE
PHOSPHORIBOSYLTRANSF
ERASE 1


(Saccharomyces
cerevisiae)
PF00156
(Pribosyltran)
4 HIS A  50
LEU A  51
ASN A 156
ILE A  63
None
1.00A 4l7iA-1g2pA:
0.0
4l7iA-1g2pA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92)
PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C)
4 ASN A 409
ARG A 445
ASN A 336
ILE A 216
None
1.03A 4l7iA-1h3gA:
0.0
4l7iA-1h3gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iho PANTOATE--BETA-ALANI
NE LIGASE


(Escherichia
coli)
PF02569
(Pantoate_ligase)
4 ARG A  73
ASP A  78
LEU A  75
ILE A   3
None
1.02A 4l7iA-1ihoA:
0.0
4l7iA-1ihoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js4 ENDO/EXOCELLULASE E4

(Thermobifida
fusca)
PF00759
(Glyco_hydro_9)
PF00942
(CBM_3)
4 LEU A 178
ASN A 101
ASP A 102
ILE A 105
None
1.06A 4l7iA-1js4A:
0.0
4l7iA-1js4A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny1 PROBABLE
POLYSACCHARIDE
DEACETYLASE PDAA


(Bacillus
subtilis)
PF01522
(Polysacc_deac_1)
4 ASP A 251
ASN A 159
ASP A 158
ILE A 120
None
0.95A 4l7iA-1ny1A:
undetectable
4l7iA-1ny1A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj5 SUCROSE-PHOSPHATASE

(Synechocystis
sp. PCC 6803)
PF05116
(S6PP)
4 ARG A  43
ASP A 190
ASP A 155
ILE A 147
SUC  A 245 (-4.9A)
MG  A 247 (-2.9A)
SUC  A 245 (-2.8A)
None
1.06A 4l7iA-1tj5A:
undetectable
4l7iA-1tj5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6y ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
5


(Homo sapiens)
PF00025
(Arf)
4 HIS A 150
ASP A 114
LEU A 115
ILE A  20
None
1.02A 4l7iA-1z6yA:
undetectable
4l7iA-1z6yA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zup HYPOTHETICAL PROTEIN
TM1739


(Thermotoga
maritima)
PF09376
(NurA)
4 ARG A 232
ASP A 157
LEU A 175
ILE A 273
None
1.06A 4l7iA-1zupA:
undetectable
4l7iA-1zupA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bz0 GTP CYCLOHYDROLASE
II


(Escherichia
coli)
PF00925
(GTP_cyclohydro2)
4 HIS A  89
ASN A  95
ASP A 135
LEU A 132
None
1.04A 4l7iA-2bz0A:
undetectable
4l7iA-2bz0A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE


(Desulfovibrio
africanus)
PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II)
4 HIS A  16
ASP A 190
LEU A 186
ASP A 151
None
1.04A 4l7iA-2c3oA:
undetectable
4l7iA-2c3oA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Aquifex
aeolicus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 ASN A 155
LEU A 333
ASN A 149
ILE A 147
None
1.00A 4l7iA-2ep7A:
undetectable
4l7iA-2ep7A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jtc STREPTOPAIN

(Streptococcus
pyogenes)
PF01640
(Peptidase_C10)
4 ASP A 175
LEU A 178
ASP A 200
ILE A 199
None
1.06A 4l7iA-2jtcA:
undetectable
4l7iA-2jtcA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE


(Homo sapiens)
PF00168
(C2)
4 HIS A  80
ASP A  48
ASP A 101
ILE A 102
None
1.06A 4l7iA-2nq3A:
undetectable
4l7iA-2nq3A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qma DIAMINOBUTYRATE-PYRU
VATE TRANSAMINASE
AND
L-2,4-DIAMINOBUTYRAT
E DECARBOXYLASE


(Vibrio
parahaemolyticus)
PF00282
(Pyridoxal_deC)
4 HIS A 859
ASP A 942
LEU A 938
ILE A 565
None
1.06A 4l7iA-2qmaA:
undetectable
4l7iA-2qmaA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tmk THYMIDYLATE KINASE

(Saccharomyces
cerevisiae)
PF02223
(Thymidylate_kin)
4 ASN A  32
LEU A 204
ASN A  89
ILE A   8
None
0.98A 4l7iA-2tmkA:
undetectable
4l7iA-2tmkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxr BOTULINUM NEUROTOXIN
TYPE G


(Clostridium
botulinum)
PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N)
4 ASN A1001
ARG A1132
ASN A1141
ILE A1140
None
0.88A 4l7iA-2vxrA:
undetectable
4l7iA-2vxrA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa)
PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc)
4 ASN A 328
ASP A 301
ASN A 356
ILE A 322
None
0.98A 4l7iA-2vz9A:
undetectable
4l7iA-2vz9A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT


(Methanosarcina
mazei)
PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7)
4 HIS A  12
ASP A   5
LEU A   8
ASP A  26
None
0.96A 4l7iA-2xr1A:
undetectable
4l7iA-2xr1A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pyrobaculum
aerophilum)
PF07995
(GSDH)
4 ASN A 122
ARG A 121
ASN A 153
ILE A 151
None
0.96A 4l7iA-3a9gA:
undetectable
4l7iA-3a9gA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Sulfolobus
shibatae)
PF01070
(FMN_dh)
4 HIS A 155
ARG A  98
ASN A 125
ILE A 152
IPE  A 701 ( 3.4A)
IPE  A 701 (-3.9A)
FNR  A 669 (-3.0A)
None
1.01A 4l7iA-3b05A:
undetectable
4l7iA-3b05A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8a HEXOKINASE-1

(Saccharomyces
cerevisiae)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
4 ASN X 237
ASP X  86
ASN X 210
ILE X 209
BGC  X 501 (-3.8A)
None
BGC  X 501 (-3.2A)
None
0.87A 4l7iA-3b8aX:
undetectable
4l7iA-3b8aX:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I


(Bacillus
anthracis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 ASN A  62
ARG A  61
ASP A   9
ILE A 135
None
COA  A 445 (-2.9A)
FAD  A 446 ( 3.5A)
None
1.07A 4l7iA-3cgdA:
undetectable
4l7iA-3cgdA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE


(Phanerochaete
chrysosporium)
PF12708
(Pectate_lyase_3)
5 HIS A 576
ASN A 147
ASP A 579
LEU A 578
ILE A 525
ZN  A 758 (-3.2A)
GOL  A 766 ( 3.7A)
None
None
None
1.44A 4l7iA-3eqnA:
undetectable
4l7iA-3eqnA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewk SENSOR PROTEIN

(Methylococcus
capsulatus)
PF13426
(PAS_9)
4 ASN A 286
ARG A 288
LEU A 238
ILE A 231
None
1.01A 4l7iA-3ewkA:
undetectable
4l7iA-3ewkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6i PUTATIVE OUTER
MEMBRANE PROTEIN,
PART OF CARBOHYDRATE
BINDING COMPLEX


(Bacteroides
thetaiotaomicron)
PF12875
(DUF3826)
4 HIS A 112
ASP A 105
LEU A 108
ILE A  72
None
1.08A 4l7iA-3g6iA:
undetectable
4l7iA-3g6iA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5


(Thermus
thermophilus;
Thermus
thermophilus;
Thermus
thermophilus)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
PF00346
(Complex1_49kDa)
PF00329
(Complex1_30kDa)
4 HIS 4 336
ASP 5 178
LEU 5 174
ASP 3 132
None
1.04A 4l7iA-3i9v4:
undetectable
4l7iA-3i9v4:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4w UNCHARACTERIZED
PROTEIN BB4693


(Bordetella
bronchiseptica)
PF04909
(Amidohydro_2)
4 ASN A  68
ARG A  67
ASN A  77
ILE A 117
None
1.04A 4l7iA-3k4wA:
undetectable
4l7iA-3k4wA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6d PUTATIVE
OXIDOREDUCTASE


(Pseudomonas
putida)
PF03446
(NAD_binding_2)
5 HIS A  80
ASN A  76
LEU A  83
ASP A  99
ILE A  97
None
1.49A 4l7iA-3l6dA:
undetectable
4l7iA-3l6dA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lae UPF0053 PROTEIN
HI0107


(Haemophilus
influenzae)
PF03471
(CorC_HlyC)
4 ASN A  20
ARG A  17
ASP A  56
ILE A  55
None
PO4  A  79 (-4.0A)
None
None
0.96A 4l7iA-3laeA:
undetectable
4l7iA-3laeA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpp BOTULINUM NEUROTOXIN
TYPE G


(Clostridium
botulinum)
PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N)
4 ASN G1001
ARG G1132
ASN G1141
ILE G1140
None
0.84A 4l7iA-3mppG:
undetectable
4l7iA-3mppG:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mue PANTOTHENATE
SYNTHETASE


(Salmonella
enterica)
PF02569
(Pantoate_ligase)
4 ARG A  73
ASP A  78
LEU A  75
ILE A   3
None
0.99A 4l7iA-3mueA:
undetectable
4l7iA-3mueA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2x UNCHARACTERIZED
PROTEIN YAGE


(Escherichia
coli)
PF00701
(DHDPS)
4 HIS A  78
ASP A  42
ASP A  32
ILE A  24
None
0.92A 4l7iA-3n2xA:
undetectable
4l7iA-3n2xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqx SECRETED
METALLOPROTEASE
MCP02


(Pseudoalteromonas
sp. SM9913)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
4 HIS A 282
ASN A 241
ASN A 286
ILE A 288
None
0.91A 4l7iA-3nqxA:
undetectable
4l7iA-3nqxA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poh ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F1


(Bacteroides
thetaiotaomicron)
PF08522
(DUF1735)
4 LEU A  77
ASN A  46
ASP A 162
ILE A 163
None
0.93A 4l7iA-3pohA:
undetectable
4l7iA-3pohA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE


(Arabidopsis
thaliana;
Vitis vinifera)
PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C)
4 ASP A  45
ASN A 427
ASP A 469
ILE A 468
None
0.95A 4l7iA-3tsyA:
undetectable
4l7iA-3tsyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7v BETA-GALACTOSIDASE

(Caulobacter
vibrioides)
PF02449
(Glyco_hydro_42)
4 ASN A 381
ASP A 390
ASN A 350
ASP A 351
None
1.02A 4l7iA-3u7vA:
undetectable
4l7iA-3u7vA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli)
PF10462
(Peptidase_M66)
4 ASN A 868
ASP A 109
ASN A 870
ASP A 873
None
1.03A 4l7iA-3ujzA:
undetectable
4l7iA-3ujzA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uma HYPOTHETICAL
PEROXIREDOXIN
PROTEIN


(Sinorhizobium
meliloti)
PF08534
(Redoxin)
4 ASP A  62
LEU A  65
ASP A  71
ILE A  72
None
0.93A 4l7iA-3umaA:
undetectable
4l7iA-3umaA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE


(Podospora
anserina)
PF00150
(Cellulase)
4 ASN A  87
ARG A  91
ASN A  83
ILE A  82
None
0.84A 4l7iA-3zizA:
undetectable
4l7iA-3zizA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuv DESIGNED ANKYRIN
REPEAT PROTEIN


(synthetic
construct)
PF13857
(Ank_5)
4 ARG B  23
ASP B  46
LEU B  48
ILE B  81
None
0.98A 4l7iA-3zuvB:
undetectable
4l7iA-3zuvB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC


(Leishmania
major)
PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C)
4 ASN A 110
ASP A 123
LEU A 125
ILE A 174
None
1.05A 4l7iA-4a26A:
undetectable
4l7iA-4a26A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2l TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE


(Bacteroides
thetaiotaomicron)
PF07494
(Reg_prop)
PF07495
(Y_Y_Y)
5 ASN A 383
ARG A 388
LEU A 381
ASN A 369
ASP A 367
None
1.33A 4l7iA-4a2lA:
undetectable
4l7iA-4a2lA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
4 ASN A 259
ASN A 253
ASP A 254
ILE A  33
None
0.91A 4l7iA-4bedA:
undetectable
4l7iA-4bedA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgv MALATE DEHYDROGENASE

(Picrophilus
torridus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ASN A 323
ASP A  96
LEU A  99
ASP A 318
ILE A 315
None
1.36A 4l7iA-4bgvA:
undetectable
4l7iA-4bgvA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwi PHYTOCHROME-LIKE
PROTEIN CPH2


(Synechocystis
sp.)
PF00360
(PHY)
PF01590
(GAF)
4 ASN A  90
ARG A  92
LEU A 153
ILE A  80
GLU  A1427 (-3.2A)
None
GLU  A1427 ( 4.9A)
CYC  A1422 (-4.0A)
1.09A 4l7iA-4bwiA:
undetectable
4l7iA-4bwiA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwy P4

(Pseudomonas
phage phi8)
PF11602
(NTPase_P4)
4 HIS A 239
ASP A 265
LEU A 262
ILE A 260
None
0.92A 4l7iA-4bwyA:
undetectable
4l7iA-4bwyA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A


(Homo sapiens)
PF00995
(Sec1)
4 ASP A  39
LEU A  66
ASN A  96
ILE A  93
None
1.09A 4l7iA-4bx9A:
undetectable
4l7iA-4bx9A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Zea mays)
PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH)
4 ASN A 670
ARG A 819
LEU A 720
ASP A 726
None
1.08A 4l7iA-4ft2A:
undetectable
4l7iA-4ft2A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ged ASCORBATE PEROXIDASE

(Leishmania
major)
PF00141
(peroxidase)
4 HIS A  68
ASN A  98
ASP A 163
ASP A 158
None
1.07A 4l7iA-4gedA:
undetectable
4l7iA-4gedA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gib BETA-PHOSPHOGLUCOMUT
ASE


(Clostridioides
difficile)
PF13419
(HAD_2)
4 ASN A  78
ASP A 138
ASN A 119
ILE A 121
None
None
PO4  A 304 (-3.8A)
None
1.06A 4l7iA-4gibA:
undetectable
4l7iA-4gibA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE


(Sulfolobus
solfataricus)
PF01941
(AdoMet_Synthase)
4 ASN A  60
ASN A 159
ASP A 160
ILE A 349
None
0.81A 4l7iA-4hpvA:
63.6
4l7iA-4hpvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN


(Thermotoga
maritima)
PF00496
(SBP_bac_5)
4 ASN A 270
ASP A 466
ASP A 498
ILE A 494
None
0.91A 4l7iA-4jsoA:
undetectable
4l7iA-4jsoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE


(Bos taurus)
PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C)
4 HIS A   6
ASP A  26
ASP A  61
ILE A  60
None
0.87A 4l7iA-4kcaA:
undetectable
4l7iA-4kcaA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
4 ASN B 349
ARG B 244
ASN B 353
ASP B 360
None
1.03A 4l7iA-4l37B:
undetectable
4l7iA-4l37B:
18.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE


(Thermococcus
kodakarensis)
PF01941
(AdoMet_Synthase)
4 HIS A  62
ARG A  95
ASP A 162
ASN A 312
None
1.01A 4l7iA-4l4qA:
55.8
4l7iA-4l4qA:
51.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2


(Bdellovibrio
bacteriovorus)
PF14566
(PTPlike_phytase)
4 ARG A 137
ASP A 146
LEU A 142
ILE A 108
None
1.07A 4l7iA-4nx8A:
undetectable
4l7iA-4nx8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens)
PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
4 ARG A 892
ASN A 853
ASP A 852
ILE A 851
None
0.95A 4l7iA-4o9xA:
undetectable
4l7iA-4o9xA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1b TOLUENE-4-MONOOXYGEN
ASE SYSTEM
FERREDOXIN SUBUNIT


(Pseudomonas
mendocina)
PF00355
(Rieske)
4 ASP H  96
LEU H   9
ASN H  32
ILE H  98
None
1.07A 4l7iA-4p1bH:
undetectable
4l7iA-4p1bH:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC


(Homo sapiens)
PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His)
4 ASP A 218
LEU A 217
ASN A 212
ILE A 335
None
1.08A 4l7iA-4phcA:
undetectable
4l7iA-4phcA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A


(Staphylococcus
aureus)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
4 ASN B1054
ASP B1040
LEU B1160
ILE B1144
None
1.00A 4l7iA-4plbB:
undetectable
4l7iA-4plbB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN


(Pseudoalteromonas
sp. SM9913)
no annotation 4 ARG H 390
LEU H 430
ASN H 386
ILE H 503
None
0.75A 4l7iA-4qfkH:
undetectable
4l7iA-4qfkH:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE


(Escherichia
coli)
PF08003
(Methyltransf_9)
4 HIS A 146
ARG A 173
LEU A 147
ILE A  11
None
0.91A 4l7iA-4qnxA:
undetectable
4l7iA-4qnxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qr8 XAA-PRO DIPEPTIDASE

(Escherichia
coli)
PF00557
(Peptidase_M24)
4 ASN A 435
ASP A 279
LEU A 282
ILE A 422
None
1.08A 4l7iA-4qr8A:
undetectable
4l7iA-4qr8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2


(Erythrobacter
litoralis)
PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2)
4 HIS A 147
ARG A 175
LEU A 148
ILE A 117
None
ANP  A 401 (-3.6A)
None
None
1.06A 4l7iA-4r3aA:
undetectable
4l7iA-4r3aA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk0 LACI FAMILY
SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR


(Enterococcus
faecalis)
PF13377
(Peripla_BP_3)
4 ASN A  81
LEU A 224
ASN A 248
ILE A 247
RIB  A 401 (-3.3A)
None
RIB  A 401 (-3.8A)
None
0.94A 4l7iA-4rk0A:
undetectable
4l7iA-4rk0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A


(Homo sapiens)
PF00145
(DNA_methylase)
4 HIS A 677
ARG A 676
ASP A 652
LEU A 648
None
0.92A 4l7iA-4u7tA:
undetectable
4l7iA-4u7tA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)


(Agrobacterium
fabrum)
PF00496
(SBP_bac_5)
4 ARG A  32
LEU A 518
ASP A 256
ILE A 257
SO4  A 601 (-4.1A)
None
None
None
1.08A 4l7iA-4ze8A:
undetectable
4l7iA-4ze8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase)
4 ASN A 172
ASP A 117
LEU A 120
ILE A 105
None
CD  A 706 ( 2.4A)
None
None
1.08A 4l7iA-4zxlA:
undetectable
4l7iA-4zxlA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE


(Vesicular
stomatitis
virus)
PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap)
4 ASN A 744
ASP A 764
ASN A 602
ILE A 604
None
0.80A 4l7iA-5a22A:
undetectable
4l7iA-5a22A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE


(Tepidanaerobacter
acetatoxydans)
PF01268
(FTHFS)
4 HIS A 365
ASN A 361
ARG A 505
ASN A  65
None
1.02A 4l7iA-5a4jA:
undetectable
4l7iA-5a4jA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA


(Schizosaccharomyces
pombe)
PF01008
(IF-2B)
5 HIS G 276
LEU G 313
ASN G 281
ASP G 282
ILE G 285
None
1.30A 4l7iA-5b04G:
undetectable
4l7iA-5b04G:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdn DNA GYRASE SUBUNIT A

(Staphylococcus
aureus)
PF00521
(DNA_topoisoIV)
4 ASN A  54
ASP A  40
LEU A 160
ILE A 144
ASN  A  54 ( 0.6A)
ASP  A  40 ( 0.5A)
LEU  A 160 ( 0.6A)
ILE  A 144 ( 0.4A)
0.99A 4l7iA-5cdnA:
undetectable
4l7iA-5cdnA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens)
PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C)
4 ASN A 226
ARG A 209
ASP A 238
LEU A 235
ASN  A 226 ( 0.6A)
ARG  A 209 ( 0.6A)
ASP  A 238 ( 0.5A)
LEU  A 235 ( 0.6A)
1.07A 4l7iA-5d7wA:
undetectable
4l7iA-5d7wA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2


(Mus musculus)
PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12)
4 ASN A1003
ARG A1000
ASP A 969
ILE A 941
None
1.02A 4l7iA-5eawA:
undetectable
4l7iA-5eawA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta)
PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8)
4 ARG A 296
LEU A 256
ASN A 300
ILE A 281
None
1.09A 4l7iA-5gmhA:
undetectable
4l7iA-5gmhA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnd PUTATIVE SERINE
PROTEASE HHOA


(Synechocystis
sp. PCC 6803)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
4 ASN A 193
ARG A 141
LEU A 140
ILE A 164
None
1.07A 4l7iA-5gndA:
undetectable
4l7iA-5gndA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1s 50S RIBOSOMAL
PROTEIN L13,
CHLOROPLASTIC


(Spinacia
oleracea)
PF00572
(Ribosomal_L13)
4 HIS L 134
ARG L 242
ASP L 238
ILE L 237
None
0.91A 4l7iA-5h1sL:
undetectable
4l7iA-5h1sL:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum)
no annotation 4 ASN B 188
ASP B 214
ASN B 210
ILE B 294
None
1.06A 4l7iA-5i70B:
undetectable
4l7iA-5i70B:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir2 CELLULASE

(Parabacteroides
johnsonii)
PF03737
(RraA-like)
4 HIS A 109
ASP A  34
ASP A 193
ILE A 194
None
0.76A 4l7iA-5ir2A:
undetectable
4l7iA-5ir2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbe INACTIVE
GLUCANSUCRASE


(Lactobacillus
reuteri)
PF02324
(Glyco_hydro_70)
4 ARG A1133
ASP A1138
LEU A1134
ASP A1165
None
1.04A 4l7iA-5jbeA:
undetectable
4l7iA-5jbeA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jod PROPLASMEPSIN IV

(Plasmodium
falciparum)
PF00026
(Asp)
4 ASN A 188
ASP A 214
ASN A 210
ILE A 294
None
1.02A 4l7iA-5jodA:
undetectable
4l7iA-5jodA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kds F5/8 TYPE C DOMAIN
PROTEIN


(Clostridium
perfringens)
PF13402
(Peptidase_M60)
4 ASP A 980
ASN A 937
ASP A 974
ILE A 938
None
0.91A 4l7iA-5kdsA:
undetectable
4l7iA-5kdsA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyo CYP101J2

(Sphingobium
yanoikuyae)
PF00067
(p450)
4 ARG A 341
ASP A 285
LEU A 342
ILE A 276
None
0.93A 4l7iA-5kyoA:
undetectable
4l7iA-5kyoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus)
PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG)
4 ASN A 792
LEU A 721
ASN A 796
ILE A 709
ASN  A 792 ( 0.6A)
LEU  A 721 ( 0.6A)
ASN  A 796 ( 0.6A)
ILE  A 709 ( 0.6A)
0.89A 4l7iA-5l5nA:
undetectable
4l7iA-5l5nA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
4 HIS B 280
ARG B 284
LEU B 655
ILE B 712
None
1.08A 4l7iA-5ldrB:
undetectable
4l7iA-5ldrB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8u LIPOATE-PROTEIN
LIGASE 1


(Plasmodium
falciparum)
PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C)
4 ASN A 218
LEU A 214
ASN A 213
ILE A 212
None
1.01A 4l7iA-5t8uA:
undetectable
4l7iA-5t8uA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX


(Lassa
mammarenavirus;
Lassa
mammarenavirus)
PF00798
(Arena_glycoprot)
PF00798
(Arena_glycoprot)
4 ARG A 248
ASN a 342
ASP a 347
ILE a 345
None
0.99A 4l7iA-5vk2A:
undetectable
4l7iA-5vk2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR


(Danio rerio)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R)
4 ASN A 188
ARG A 154
LEU A 157
ILE A 369
None
0.95A 4l7iA-5w81A:
undetectable
4l7iA-5w81A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS


(Helicobacter
pylori)
no annotation 4 ASN A   9
LEU A   7
ASN A 361
ILE A 366
None
1.06A 4l7iA-5wt4A:
undetectable
4l7iA-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE


(Geobacillus sp.
12AMOR1)
no annotation 5 ARG A 220
ASP A 233
LEU A 221
ASN A 120
ILE A 119
None
1.46A 4l7iA-5xksA:
undetectable
4l7iA-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE


(unidentified)
PF00465
(Fe-ADH)
4 ARG A 218
LEU A 165
ASN A 237
ILE A 234
None
1.04A 4l7iA-5xn8A:
undetectable
4l7iA-5xn8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum)
no annotation 4 HIS A 565
ASN A 902
ASP A 642
ILE A 649
None
RAM  A1003 ( 4.1A)
None
None
0.83A 4l7iA-5xqoA:
undetectable
4l7iA-5xqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb RESTRICTION
ENDONUCLEASE S
SUBUNITS


(Caldanaerobacter
subterraneus)
no annotation 4 ASN D 110
ARG D 111
LEU D 119
ILE D 155
None
1.08A 4l7iA-5ybbD:
undetectable
4l7iA-5ybbD:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es4 SYNCRIP, ISOFORM K

(Drosophila
melanogaster)
no annotation 4 ASN A 204
ARG A 146
LEU A 180
ILE A 230
None
1.09A 4l7iA-6es4A:
undetectable
4l7iA-6es4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9c GLYCOPROTEIN

(Rift Valley
fever
phlebovirus)
no annotation 4 ASP A 370
LEU A 368
ASN A 366
ILE A 442
None
0.87A 4l7iA-6f9cA:
undetectable
4l7iA-6f9cA:
undetectable