SIMILAR PATTERNS OF AMINO ACIDS FOR 4L6H_A_MTXA803_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		7 LYS A  18
ASP A 495
TRP A 514
SER A 517
VAL A 523
PRO A 526
TRP A 567
 None
 0.39A 4l6hA-1u1hA:
54.0		 4l6hA-1u1hA:
49.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  18
ASP A 467
TRP A 486
SER A 489
PRO A 498
 C2F  A1882 (-2.4A)
C2F  A1882 ( 4.9A)
None
C2F  A1882 (-3.0A)
None
 0.82A 4l6hA-1xpgA:
50.0		 4l6hA-1xpgA:
42.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  18
TRP A 486
SER A 489
PRO A 498
TRP A 539
 C2F  A1882 (-2.4A)
None
C2F  A1882 (-3.0A)
None
C2F  A1882 (-3.7A)
 0.51A 4l6hA-1xpgA:
50.0		 4l6hA-1xpgA:
42.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 ASP A 478
TRP A 497
SER A 500
VAL A 506
PRO A 509
 None
 0.79A 4l6hA-2nq5A:
55.8		 4l6hA-2nq5A:
43.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  19
ASP A 478
TRP A 497
TYR A 116
VAL A 506
 None
 1.47A 4l6hA-2nq5A:
55.8		 4l6hA-2nq5A:
43.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  19
ASP A 478
TRP A 497
VAL A 506
PRO A 509
 None
 0.54A 4l6hA-2nq5A:
55.8		 4l6hA-2nq5A:
43.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  19
TRP A 497
VAL A 506
PRO A 509
TRP A 550
 None
 0.63A 4l6hA-2nq5A:
55.8		 4l6hA-2nq5A:
43.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 TRP A 497
SER A 500
VAL A 506
PRO A 509
TRP A 550
 None
 0.91A 4l6hA-2nq5A:
55.8		 4l6hA-2nq5A:
43.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		9 LYS A  19
ASP A 504
TRP A 523
SER A 526
TYR A 527
TYR A 531
VAL A 532
PRO A 535
TRP A 576
 None
 0.48A 4l6hA-3ppcA:
68.1		 4l6hA-3ppcA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0v TEK TYROSINE KINASE
VARIANT

(Homo sapiens) 		PF00041
(fn3)
PF10430
(Ig_Tie2_1) 		5 ASP A  60
SER A 190
TYR A 156
TYR A 189
VAL A 188
 None
 1.42A 4l6hA-4k0vA:
0.0		 4l6hA-4k0vA:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		7 LYS A  19
ASP A 499
TRP A 518
SER A 521
VAL A 527
PRO A 530
TRP A 571
 None
 0.38A 4l6hA-4ztxA:
63.7		 4l6hA-4ztxA:
60.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		7 LYS A  19
TRP A 518
SER A 521
TYR A 522
VAL A 527
PRO A 530
TRP A 571
 None
 0.93A 4l6hA-4ztxA:
63.7		 4l6hA-4ztxA:
60.25