SIMILAR PATTERNS OF AMINO ACIDS FOR 4L65_A_C2FA802

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  18
SER A 517
TYR A 518
VAL A 523
TRP A 567
 None
 0.52A 4l65A-1u1hA:
53.9		 4l65A-1u1hA:
49.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  18
ASP A 467
SER A 489
TYR A 490
ARG A 493
 C2F  A1882 (-2.4A)
C2F  A1882 ( 4.9A)
C2F  A1882 (-3.0A)
None
C2F  A1882 ( 3.5A)
 0.79A 4l65A-1xpgA:
49.6		 4l65A-1xpgA:
42.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  18
SER A 489
TYR A 490
ARG A 493
TRP A 539
 C2F  A1882 (-2.4A)
C2F  A1882 (-3.0A)
None
C2F  A1882 ( 3.5A)
C2F  A1882 (-3.7A)
 0.72A 4l65A-1xpgA:
49.6		 4l65A-1xpgA:
42.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  19
TYR A 501
ARG A 504
VAL A 506
TRP A 550
 None
 0.92A 4l65A-2nq5A:
55.9		 4l65A-2nq5A:
43.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		6 LYS A  19
ASP A 504
SER A 526
TYR A 531
VAL A 532
TRP A 576
 None
 0.52A 4l65A-3ppcA:
69.3		 4l65A-3ppcA:
99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  19
ASN A 120
ASP A 499
VAL A 527
TRP A 571
 None
GOL  A3002 (-4.2A)
None
None
None
 0.94A 4l65A-4ztxA:
64.5		 4l65A-4ztxA:
60.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  19
ASN A 120
SER A 521
VAL A 527
TRP A 571
 None
GOL  A3002 (-4.2A)
None
None
None
 0.61A 4l65A-4ztxA:
64.5		 4l65A-4ztxA:
60.25