SIMILAR PATTERNS OF AMINO ACIDS FOR 4L64_A_C2FA802_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bco BACTERIOPHAGE MU
TRANSPOSASE

(Escherichia
virus Mu) 		PF02914
(DDE_2)
PF09299
(Mu-transpos_C) 		4 SER A 510
TYR A 354
ARG A 353
VAL A 307
 None
 1.38A 4l64A-1bcoA:
1.3		 4l64A-1bcoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chm CREATINE
AMIDINOHYDROLASE

(Pseudomonas
putida) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 SER A  79
TYR A  66
ARG A  64
VAL A  98
 None
 1.22A 4l64A-1chmA:
0.7		 4l64A-1chmA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5u INTIMIN

(Escherichia
coli) 		PF02368
(Big_2)
PF07979
(Intimin_C) 		4 LYS I  63
SER I  45
VAL I  53
TRP I  43
 None
 1.38A 4l64A-1e5uI:
undetectable		 4l64A-1e5uI:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp0 CREATINE
AMIDINOHYDROLASE

(Actinobacillus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 SER A  79
TYR A  66
ARG A  64
VAL A  97
 None
 1.37A 4l64A-1kp0A:
undetectable		 4l64A-1kp0A:
17.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		6 LYS A  18
TRP A 514
SER A 517
TYR A 518
VAL A 523
TRP A 567
 None
 0.37A 4l64A-1u1hA:
54.0		 4l64A-1u1hA:
49.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		4 LYS 1 203
TYR 1 210
ARG 1 206
VAL 1 319
 None
 1.18A 4l64A-1wao1:
0.0		 4l64A-1wao1:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		6 LYS A  18
TRP A 486
SER A 489
TYR A 490
ARG A 493
TRP A 539
 C2F  A1882 (-2.4A)
None
C2F  A1882 (-3.0A)
None
C2F  A1882 ( 3.5A)
C2F  A1882 (-3.7A)
 0.49A 4l64A-1xpgA:
49.6		 4l64A-1xpgA:
42.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eqk TUDOR
DOMAIN-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF00567
(TUDOR) 		4 TRP A  38
TYR A  57
ARG A  40
VAL A  30
 None
 1.32A 4l64A-2eqkA:
undetectable		 4l64A-2eqkA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j59 RHO-GTPASE
ACTIVATING PROTEIN
10

(Homo sapiens) 		PF15410
(PH_9) 		4 LYS M 931
SER M 968
TYR M 970
ARG M 965
 None
 1.49A 4l64A-2j59M:
undetectable		 4l64A-2j59M:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780

(Pyrococcus
abyssi) 		PF05958
(tRNA_U5-meth_tr) 		4 LYS A 193
TRP A 163
SER A 221
TYR A 222
 None
 1.23A 4l64A-2jjqA:
undetectable		 4l64A-2jjqA:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		6 LYS A  19
TRP A 497
TYR A 501
ARG A 504
VAL A 506
TRP A 550
 None
 0.83A 4l64A-2nq5A:
55.9		 4l64A-2nq5A:
43.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		6 TRP A 497
SER A 500
TYR A 501
ARG A 504
VAL A 506
TRP A 550
 None
 1.03A 4l64A-2nq5A:
55.9		 4l64A-2nq5A:
43.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4

(Azotobacter
vinelandii) 		PF12708
(Pectate_lyase_3) 		4 SER A 165
ARG A 140
VAL A 141
TRP A 121
 None
 1.35A 4l64A-2pyhA:
undetectable		 4l64A-2pyhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 SER A 238
TYR A 452
ARG A 249
VAL A 217
 None
 1.47A 4l64A-2qf7A:
8.7		 4l64A-2qf7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 SER A 194
TYR A 212
VAL A 196
TRP A 293
 None
None
HEM  A1100 ( 4.2A)
None
 1.31A 4l64A-3dy5A:
undetectable		 4l64A-3dy5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fky GLUTAMINE SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 SER A 197
TYR A 168
VAL A 143
TRP A 244
 None
 1.14A 4l64A-3fkyA:
undetectable		 4l64A-3fkyA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fl7 EPHRIN RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF01404
(Ephrin_lbd) 		4 TRP A 456
TYR A 473
ARG A 485
VAL A 454
 None
 1.46A 4l64A-3fl7A:
undetectable		 4l64A-3fl7A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv1 DISULFIDE
INTERCHANGE PROTEIN

(Neisseria
gonorrhoeae) 		PF13098
(Thioredoxin_2) 		4 LYS A 160
SER A 247
TYR A 246
ARG A 153
 None
 1.50A 4l64A-3gv1A:
undetectable		 4l64A-3gv1A:
12.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  19
TRP A 523
SER A 526
VAL A 532
TRP A 576
 None
 0.20A 4l64A-3ppcA:
68.5		 4l64A-3ppcA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdy BETA-1,3-1,4-GLUCANA
SE

(Paecilomyces
sp.
'thermophila') 		no annotation 4 SER A  68
TYR A  32
VAL A  55
TRP A 286
 None
 1.48A 4l64A-3wdyA:
undetectable		 4l64A-3wdyA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epc N-ACETYLMURAMOYL-L-A
LANINE AMIDASE

(Staphylococcus
epidermidis) 		PF13457
(SH3_8) 		4 LYS A 741
TRP A 763
TYR A 771
VAL A 752
 MLY  A 740 ( 3.4A)
None
None
None
 1.46A 4l64A-4epcA:
undetectable		 4l64A-4epcA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd7 PUTATIVE
ARYLALKYLAMINE
N-ACETYLTRANSFERASE
7

(Aedes aegypti) 		PF00583
(Acetyltransf_1) 		4 SER A 154
TYR A  51
VAL A 101
TRP A  78
 None
 1.42A 4l64A-4fd7A:
undetectable		 4l64A-4fd7A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu0 CELLULASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		4 LYS A  48
TRP A 133
TYR A 179
VAL A 130
 None
 1.13A 4l64A-4hu0A:
8.2		 4l64A-4hu0A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		4 LYS A 947
SER A 941
ARG A 943
VAL A 869
 None
 1.18A 4l64A-4ifqA:
2.1		 4l64A-4ifqA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 4 TYR A 220
ARG A 222
VAL A 241
TRP A 229
 None
 1.49A 4l64A-4tz5A:
undetectable		 4l64A-4tz5A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 LYS A 529
SER A  70
ARG A  68
VAL A 587
 None
 1.34A 4l64A-4wjlA:
undetectable		 4l64A-4wjlA:
23.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  19
TRP A 518
SER A 521
VAL A 527
TRP A 571
 None
 0.29A 4l64A-4ztxA:
64.0		 4l64A-4ztxA:
60.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 TRP A 115
SER A 103
TYR A  42
ARG A 101
 None
 1.37A 4l64A-5a3yA:
undetectable		 4l64A-5a3yA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxn THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 TRP A 115
SER A 103
TYR A  42
ARG A 101
 None
 1.37A 4l64A-5fxnA:
undetectable		 4l64A-5fxnA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6q H5AL

(Homo sapiens) 		PF07686
(V-set) 		4 SER A  88
TYR A  29
ARG A  89
VAL A  97
 None
 1.22A 4l64A-5l6qA:
undetectable		 4l64A-5l6qA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 SER A 687
TYR A 661
ARG A 662
VAL A 685
 None
 1.18A 4l64A-5okoA:
undetectable		 4l64A-5okoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykn PROBABLE
LYSINE-SPECIFIC
DEMETHYLASE JMJ14

(Arabidopsis
thaliana) 		no annotation 4 SER A 280
ARG A 276
VAL A 412
TRP A 417
 None
 1.45A 4l64A-5yknA:
undetectable		 4l64A-5yknA:
undetectable