SIMILAR PATTERNS OF AMINO ACIDS FOR 4L4F_A_CAMA503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3

(Reovirus sp.) 		PF00979
(Reovirus_cap) 		4 THR A 204
THR A 262
LEU A 197
VAL A 356
 None
 0.93A 4l4fA-1fn9A:
0.0		 4l4fA-1fn9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase) 		4 PHE A 297
THR A  69
THR A 299
VAL A 241
 None
 0.89A 4l4fA-1fsuA:
undetectable		 4l4fA-1fsuA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 THR A 396
LEU A 345
VAL A 257
VAL A 404
 None
 1.08A 4l4fA-1mb9A:
0.0		 4l4fA-1mb9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 PHE A 107
THR A  78
VAL A 195
ASP A 104
 None
 1.05A 4l4fA-1mpxA:
0.0		 4l4fA-1mpxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		4 THR A 313
LEU A 178
VAL A 181
VAL A 191
 None
 0.79A 4l4fA-1vpeA:
0.0		 4l4fA-1vpeA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wk4 TTK003001606

(Thermus
thermophilus) 		PF00583
(Acetyltransf_1) 		4 PHE A 139
TYR A 140
LEU A  91
VAL A  96
 MES  A 201 ( 4.3A)
None
None
MES  A 201 ( 4.4A)
 1.14A 4l4fA-1wk4A:
undetectable		 4l4fA-1wk4A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xgy K42-41L FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  27
THR H  94
LEU H   4
VAL H  71
 None
 1.11A 4l4fA-1xgyH:
0.0		 4l4fA-1xgyH:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y5e MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Bacillus cereus) 		PF00994
(MoCF_biosynth) 		4 THR A  78
LEU A  97
VAL A  94
VAL A  53
 None
 0.95A 4l4fA-1y5eA:
0.0		 4l4fA-1y5eA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct8 METHIONYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.11A 4l4fA-2ct8A:
0.0		 4l4fA-2ct8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		4 THR A 398
LEU A 449
VAL A 447
VAL A 437
 None
 0.97A 4l4fA-2eceA:
undetectable		 4l4fA-2eceA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		4 PHE A  99
TYR A 329
THR A  89
VAL A 204
 None
 1.13A 4l4fA-2f2aA:
undetectable		 4l4fA-2f2aA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 THR A 176
THR A 235
VAL A 213
ASP A 270
 MG  A 602 ( 3.3A)
None
None
MG  A 602 ( 4.8A)
 1.11A 4l4fA-2f43A:
undetectable		 4l4fA-2f43A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 THR A 577
LEU A 780
VAL A 776
VAL A 646
 None
 1.01A 4l4fA-2fgeA:
undetectable		 4l4fA-2fgeA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iue INTEGRIN BETA-2-LIKE
PROTEIN

(Mus musculus) 		PF00362
(Integrin_beta) 		4 TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 1.06A 4l4fA-2iueA:
undetectable		 4l4fA-2iueA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j41 GUANYLATE KINASE

(Staphylococcus
aureus) 		PF00625
(Guanylate_kin) 		4 THR A  85
THR A  93
LEU A 102
VAL A 100
 None
 1.13A 4l4fA-2j41A:
undetectable		 4l4fA-2j41A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8d PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB

(Methanothermobacter
thermautotrophicus) 		PF01641
(SelR) 		4 PHE A  90
LEU A 123
VAL A 114
VAL A  94
 None
 0.94A 4l4fA-2k8dA:
undetectable		 4l4fA-2k8dA:
17.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 PHE A  87
TYR A  96
LEU A 244
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
None
 0.74A 4l4fA-2m56A:
67.7		 4l4fA-2m56A:
98.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		8 PHE A  87
TYR A  96
THR A 101
THR A 185
LEU A 244
VAL A 247
VAL A 295
ASP A 297
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
None
HEM  A 501 (-4.5A)
None
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
 0.38A 4l4fA-2m56A:
67.7		 4l4fA-2m56A:
98.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz4 FAB FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  27
THR H  98
LEU H   4
VAL H  72
 None
 1.02A 4l4fA-2oz4H:
undetectable		 4l4fA-2oz4H:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		4 THR A 630
LEU A 582
VAL A 578
VAL A 650
 None
 1.02A 4l4fA-2pi5A:
undetectable		 4l4fA-2pi5A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Homo sapiens) 		PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF) 		4 THR A 441
LEU A 455
VAL A 451
VAL A 288
 None
 1.13A 4l4fA-2pz1A:
undetectable		 4l4fA-2pz1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzh HYPOTHETICAL PROTEIN
HP_0496

(Helicobacter
pylori) 		PF03061
(4HBT) 		4 TYR A  21
THR A  10
LEU A  66
VAL A   5
 None
 0.95A 4l4fA-2pzhA:
undetectable		 4l4fA-2pzhA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8r SENSOR PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF02702
(KdpD) 		4 THR A 204
LEU A   8
VAL A   6
ASP A 147
 None
 1.06A 4l4fA-2r8rA:
undetectable		 4l4fA-2r8rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8r SENSOR PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF02702
(KdpD) 		4 THR A 204
LEU A   8
VAL A 121
ASP A 147
 None
 0.91A 4l4fA-2r8rA:
undetectable		 4l4fA-2r8rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd7 COMPLEMENT COMPONENT
C8 ALPHA CHAIN

(Homo sapiens) 		PF01823
(MACPF) 		4 THR A 410
THR A 260
LEU A 350
VAL A 386
 None
 0.77A 4l4fA-2rd7A:
undetectable		 4l4fA-2rd7A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 LEU A  68
VAL A  65
VAL A  91
ASP A 404
 None
 1.09A 4l4fA-2xvgA:
undetectable		 4l4fA-2xvgA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cav 3-OXO-5-BETA-STEROID
4-DEHYDROGENASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 THR A 105
THR A  25
LEU A 109
VAL A  64
 None
 1.15A 4l4fA-3cavA:
undetectable		 4l4fA-3cavA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cn7 CARBOXYLESTERASE

(Pseudomonas
aeruginosa) 		PF02230
(Abhydrolase_2) 		4 PHE A  45
THR A  43
LEU A 135
VAL A  39
 None
 0.84A 4l4fA-3cn7A:
undetectable		 4l4fA-3cn7A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		4 PHE A 309
TYR A 200
THR A 174
VAL A 335
 None
PMP  A 401 (-4.3A)
None
None
 1.12A 4l4fA-3cq5A:
undetectable		 4l4fA-3cq5A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 THR A 218
LEU A 245
VAL A 243
VAL A 233
 None
 1.10A 4l4fA-3cttA:
undetectable		 4l4fA-3cttA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB

(Sinorhizobium
meliloti) 		no annotation 4 THR A 298
LEU A 198
VAL A  76
VAL A 216
 SR  A 502 ( 4.3A)
None
None
None
 1.14A 4l4fA-3e4pA:
undetectable		 4l4fA-3e4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etu PROTEIN TRANSPORT
PROTEIN DSL1

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		4 PHE A 179
TYR A 167
LEU A 123
VAL A  68
 None
 1.15A 4l4fA-3etuA:
undetectable		 4l4fA-3etuA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III

(Xanthomonas
oryzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 THR A  66
THR A 116
LEU A 108
VAL A 110
 None
 1.15A 4l4fA-3fk5A:
undetectable		 4l4fA-3fk5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		4 PHE A 302
LEU A  32
VAL A 344
VAL A 389
 None
 1.11A 4l4fA-3g8mA:
undetectable		 4l4fA-3g8mA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		4 PHE A  92
TYR A 322
THR A  82
VAL A 197
 None
 1.04A 4l4fA-3h0lA:
undetectable		 4l4fA-3h0lA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ

(Carboxydothermus
hydrogenoformans) 		PF14450
(FtsA) 		4 THR A  94
THR A 100
LEU A 122
VAL A  64
 None
 0.94A 4l4fA-3h1qA:
undetectable		 4l4fA-3h1qA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm0 PROBABLE
THIOESTERASE

(Bartonella
henselae) 		PF03061
(4HBT) 		4 TYR A  38
THR A  27
LEU A  90
VAL A  22
 None
 1.01A 4l4fA-3hm0A:
undetectable		 4l4fA-3hm0A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 PHE B 115
TYR B 116
LEU B 196
VAL B 225
 None
 1.11A 4l4fA-3lcvB:
undetectable		 4l4fA-3lcvB:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12979
(DUF3863)
PF12980
(DUF3864) 		4 THR A 338
LEU A  53
VAL A  51
VAL A 290
 None
 0.98A 4l4fA-3lm3A:
undetectable		 4l4fA-3lm3A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A 226
THR A 232
VAL A 262
ASP A 253
 None
 1.11A 4l4fA-3lm5A:
undetectable		 4l4fA-3lm5A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9v FAD-DEPENDENT
OXIDOREDUCTASE

(Actinomadura
kijaniata) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 THR A 151
LEU A 163
VAL A 199
VAL A 170
 None
 1.01A 4l4fA-3m9vA:
undetectable		 4l4fA-3m9vA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 THR A 351
THR A  54
LEU A  14
VAL A 389
 None
 0.69A 4l4fA-3n2cA:
undetectable		 4l4fA-3n2cA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvq SEMAPHORIN-7A

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF13895
(Ig_2) 		4 THR A 467
LEU A 133
VAL A  77
VAL A 485
 None
 1.14A 4l4fA-3nvqA:
undetectable		 4l4fA-3nvqA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2c PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
ovatus) 		PF06824
(Glyco_hydro_125) 		4 TYR A 374
THR A 419
VAL A 381
VAL A 355
 None
 1.13A 4l4fA-3p2cA:
undetectable		 4l4fA-3p2cA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 PHE A1532
LEU A1511
VAL A1498
VAL A1489
 None
None
None
GOL  A   1 ( 4.7A)
 0.93A 4l4fA-3pvlA:
undetectable		 4l4fA-3pvlA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdm DMF4 BETA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR E 108
THR E  13
LEU E  21
VAL E  19
 None
 0.91A 4l4fA-3qdmE:
undetectable		 4l4fA-3qdmE:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.83A 4l4fA-3rimA:
undetectable		 4l4fA-3rimA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		4 THR A  71
LEU A 152
VAL A 150
VAL A 103
 None
 0.96A 4l4fA-3skvA:
undetectable		 4l4fA-3skvA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF) 		4 PHE A 586
LEU A 590
VAL A 444
ASP A 441
 None
 0.94A 4l4fA-3t6gA:
undetectable		 4l4fA-3t6gA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora) 		PF05711
(TylF) 		4 THR A 181
LEU A 175
VAL A 171
VAL A 161
 None
 0.96A 4l4fA-3tosA:
undetectable		 4l4fA-3tosA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN

(Methylacidiphilum
infernorum) 		PF00042
(Globin) 		4 PHE A  43
TYR A  29
LEU A  54
VAL A  87
 HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
 1.08A 4l4fA-3ubcA:
undetectable		 4l4fA-3ubcA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 THR A 391
THR A 266
VAL A 413
VAL A 112
 None
 1.02A 4l4fA-3v7nA:
undetectable		 4l4fA-3v7nA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01554
(MatE) 		4 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.00A 4l4fA-3wbnA:
undetectable		 4l4fA-3wbnA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx0 PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 THR A 249
LEU A  12
VAL A  15
VAL A 232
 None
 1.06A 4l4fA-4bx0A:
undetectable		 4l4fA-4bx0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0r PUTATIVE AMINO ACID
BINDING PROTEIN

(Streptococcus
mutans) 		PF00497
(SBP_bac_3) 		4 THR A  86
LEU A 211
VAL A  35
ASP A  28
 None
 1.01A 4l4fA-4c0rA:
undetectable		 4l4fA-4c0rA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0r PUTATIVE AMINO ACID
BINDING PROTEIN

(Streptococcus
mutans) 		PF00497
(SBP_bac_3) 		4 THR A  86
LEU A 211
VAL A 207
ASP A  28
 None
 1.13A 4l4fA-4c0rA:
undetectable		 4l4fA-4c0rA:
18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 TYR A  98
THR A 103
THR A 187
LEU A 252
VAL A 303
 None
GOL  A1419 (-3.8A)
None
HEM  A1418 (-4.0A)
GOL  A1419 (-3.9A)
 0.48A 4l4fA-4c9mA:
59.2		 4l4fA-4c9mA:
45.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 TYR A  98
THR A 187
LEU A 252
VAL A 303
ASP A 305
 None
None
HEM  A1418 (-4.0A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
 0.56A 4l4fA-4c9mA:
59.2		 4l4fA-4c9mA:
45.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e13 DIKETOREDUCTASE

(Acinetobacter
baylyi) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 PHE A 117
THR A 115
LEU A  79
VAL A  83
 None
None
None
GOL  A 305 (-4.9A)
 1.16A 4l4fA-4e13A:
undetectable		 4l4fA-4e13A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 THR A 302
LEU A 281
VAL A 280
VAL A 119
 None
 1.15A 4l4fA-4eutA:
undetectable		 4l4fA-4eutA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewj ENOLASE 2

(Streptococcus
suis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 PHE A 355
THR A 389
LEU A 130
VAL A 370
 None
 1.14A 4l4fA-4ewjA:
undetectable		 4l4fA-4ewjA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.09A 4l4fA-4g1pA:
undetectable		 4l4fA-4g1pA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 THR A 192
THR A 188
VAL A 224
ASP A 162
 None
 1.06A 4l4fA-4ga6A:
undetectable		 4l4fA-4ga6A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB
YENC2

(Yersinia
entomophaga;
Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
no annotation 		4 PHE A1220
TYR A1231
THR A1340
THR B 189
 None
 1.14A 4l4fA-4iglA:
undetectable		 4l4fA-4iglA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 THR A 158
LEU A 141
VAL A 146
VAL A 164
 None
 1.11A 4l4fA-4im7A:
undetectable		 4l4fA-4im7A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqz UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF16253
(DUF4909) 		4 PHE A  79
TYR A 100
VAL A  72
ASP A  70
 None
 1.16A 4l4fA-4lqzA:
undetectable		 4l4fA-4lqzA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		4 TYR A 314
LEU A 342
VAL A 350
VAL A 355
 None
 1.06A 4l4fA-4n0rA:
undetectable		 4l4fA-4n0rA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE

(Mycobacterium
tuberculosis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 PHE A 153
LEU A  21
VAL A  17
VAL A 164
 None
 1.10A 4l4fA-4ol9A:
undetectable		 4l4fA-4ol9A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 THR A4328
LEU A4333
VAL A4336
ASP A4476
 None
 1.16A 4l4fA-4opeA:
undetectable		 4l4fA-4opeA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN

(Pyrococcus
horikoshii) 		PF00375
(SDF) 		4 TYR A  88
THR A 403
LEU A 250
ASP A 312
 None
 1.07A 4l4fA-4oyeA:
undetectable		 4l4fA-4oyeA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA

(Schizosaccharomyces
pombe) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		4 THR A 192
THR A 121
LEU A 174
VAL A  89
 None
 1.13A 4l4fA-4pz7A:
undetectable		 4l4fA-4pz7A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 PHE B 473
THR B 503
LEU B 449
VAL B 445
 None
 1.13A 4l4fA-4q4aB:
undetectable		 4l4fA-4q4aB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7l UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 PHE A 473
THR A 503
LEU A 449
VAL A 445
 None
 1.15A 4l4fA-4q7lA:
undetectable		 4l4fA-4q7lA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txd CSC2

(Thermofilum
pendens) 		no annotation 4 THR A  85
LEU A 249
VAL A 264
VAL A  39
 None
 0.88A 4l4fA-4txdA:
undetectable		 4l4fA-4txdA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udu PROTEIN TRBV7-9,
T-CELL RECEPTOR
BETA-2 CHAIN C
REGION

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  91
THR B  39
LEU B  47
ASP B  87
 None
 1.10A 4l4fA-4uduB:
undetectable		 4l4fA-4uduB:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjb PUTATIVE
AMIDOHYDROLASE/PEPTI
DASE

(Burkholderia
cenocepacia) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 THR A 121
THR A  85
LEU A 114
VAL A 110
 None
 0.99A 4l4fA-4wjbA:
undetectable		 4l4fA-4wjbA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 THR A 124
LEU A 167
VAL A 165
VAL A 308
 None
 1.06A 4l4fA-4x0oA:
undetectable		 4l4fA-4x0oA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5j MINI SPINDLES TOG3

(Drosophila
melanogaster) 		no annotation 4 PHE A 701
THR A 673
LEU A 645
VAL A 663
 None
 1.05A 4l4fA-4y5jA:
undetectable		 4l4fA-4y5jA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ

(Escherichia
coli) 		PF03180
(Lipoprotein_9) 		4 PHE X 246
TYR X 250
THR X 109
VAL X  37
 None
 1.15A 4l4fA-4yahX:
undetectable		 4l4fA-4yahX:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj5 PYRUVATE KINASE PKM

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		4 THR A 195
THR A 121
LEU A 183
VAL A 176
 None
 1.13A 4l4fA-4yj5A:
undetectable		 4l4fA-4yj5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT

(Caldanaerobacter
subterraneus) 		no annotation 4 THR J 188
LEU J  22
VAL J  24
VAL J  79
 None
 0.86A 4l4fA-4ymwJ:
undetectable		 4l4fA-4ymwJ:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z23 CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		4 TYR A 133
LEU A  79
VAL A  75
VAL A 125
 None
 1.07A 4l4fA-4z23A:
undetectable		 4l4fA-4z23A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8t AVRRXO1-ORF1

(Xanthomonas
oryzae) 		no annotation 4 THR A 184
LEU A 142
VAL A 243
VAL A 194
 None
 0.88A 4l4fA-4z8tA:
undetectable		 4l4fA-4z8tA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.03A 4l4fA-5a2rA:
undetectable		 4l4fA-5a2rA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c08 1E6 TCR BETA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR E 111
THR E  13
LEU E  21
VAL E  19
 None
 0.95A 4l4fA-5c08E:
undetectable		 4l4fA-5c08E:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 THR B 377
LEU B 234
VAL B 106
ASP B 186
 None
 1.09A 4l4fA-5c24B:
undetectable		 4l4fA-5c24B:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5v PRP38

(Chaetomium
thermophilum) 		PF03371
(PRP38) 		4 TYR A 105
LEU A 119
VAL A  65
VAL A  56
 None
 0.98A 4l4fA-5f5vA:
undetectable		 4l4fA-5f5vA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ier OHP9

(synthetic
construct) 		PF02136
(NTF2) 		4 PHE A  59
THR A  16
THR A  43
LEU A  69
 3QZ  A 201 ( 4.5A)
3QZ  A 201 (-2.9A)
3QZ  A 201 (-3.2A)
3QZ  A 201 (-4.0A)
 0.91A 4l4fA-5ierA:
undetectable		 4l4fA-5ierA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		4 THR A 146
LEU A 171
VAL A 185
VAL A 104
 None
 1.15A 4l4fA-5izdA:
undetectable		 4l4fA-5izdA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k53 ALDEHYDE
DEFORMYLATING
OXYGENASE

(Oscillatoria
sp.) 		PF11266
(Ald_deCOase) 		4 TYR A  17
LEU A  74
VAL A  76
VAL A  28
 None
None
None
STE  A 502 ( 4.8A)
 0.99A 4l4fA-5k53A:
undetectable		 4l4fA-5k53A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 4 TYR A 322
THR A 343
VAL A 547
VAL A 543
 None
 1.01A 4l4fA-5mz9A:
undetectable		 4l4fA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT B
HETERODISULFIDE
REDUCTASE, SUBUNIT C

(Methanothermococcus
thermolithotrophicus;
Methanothermococcus
thermolithotrophicus) 		PF02754
(CCG)
PF13183
(Fer4_8) 		4 THR C  50
LEU B 207
VAL B 200
ASP C  73
 None
 1.01A 4l4fA-5odrC:
undetectable		 4l4fA-5odrC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy7 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3) 		4 PHE B 176
LEU B 187
VAL B 183
VAL B 318
 None
 1.02A 4l4fA-5sy7B:
undetectable		 4l4fA-5sy7B:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t06 ACYL-COA THIOESTER
HYDROLASE YBGC

(Escherichia
coli) 		PF03061
(4HBT) 		4 TYR A  28
THR A  17
LEU A  76
VAL A  12
 None
 0.93A 4l4fA-5t06A:
undetectable		 4l4fA-5t06A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thw DEACYLASE

(Burkholderia
multivorans) 		PF01546
(Peptidase_M20) 		4 THR A 129
THR A  93
LEU A 122
VAL A 118
 None
 0.97A 4l4fA-5thwA:
undetectable		 4l4fA-5thwA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvd NUCLEOTIDYLTRANSFERA
SE-LIKE PROTEIN

(Paracoccidioides
brasiliensis) 		no annotation 4 THR A  46
LEU A   9
VAL A  13
ASP A  50
 MG  A 302 ( 4.7A)
None
None
MG  A 302 (-2.5A)
 1.16A 4l4fA-5uvdA:
undetectable		 4l4fA-5uvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1m U6 SNRNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF09749
(HVSL) 		4 PHE A 151
LEU A 123
VAL A  87
VAL A 175
 None
 1.10A 4l4fA-5v1mA:
undetectable		 4l4fA-5v1mA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtn REPLICATION
INITIATION AND
MEMBRANE ATTACHMENT
PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 4 PHE A 211
LEU A 266
VAL A 229
VAL A 220
 None
 1.10A 4l4fA-5wtnA:
undetectable		 4l4fA-5wtnA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2g CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Campylobacter
jejuni) 		no annotation 4 PHE A   7
TYR A 459
THR A 651
LEU A 435
 None
 0.93A 4l4fA-5x2gA:
undetectable		 4l4fA-5x2gA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 4 THR A 805
LEU A 761
VAL A 760
VAL A 676
 None
 1.02A 4l4fA-6gh2A:
undetectable		 4l4fA-6gh2A:
undetectable